OOIR: Observatory of International Research

Papers

(The TQCC of Protein & Cell is 17. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy	857
A practical guide to amplicon and metagenomic analysis of microbiome data	381
The role of the gut microbiome and its metabolites in metabolic diseases	186
Ferroptosis, radiotherapy, and combination therapeutic strategies	183
Mapping the epigenetic modifications of DNA and RNA	177
A human circulating immune cell landscape in aging and COVID-19	172
Targeting the alternative bile acid synthetic pathway for metabolic diseases	156
The microbiome in inflammatory bowel diseases: from pathogenesis to therapy	135
Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332	129
Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2	118
Unexpected guests in the tumor microenvironment: microbiome in cancer	105
Insights into epigenetic patterns in mammalian early embryos	98
High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors	93
Mesenchymal stem cell therapy for acute respiratory distress syndrome: from basic to clinics	92
The potential of using blood circular RNA as liquid biopsy biomarker for human diseases	92
New avenues for systematically inferring cell-cell communication: through single-cell transcriptomics data	87
Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos	85
SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer	84
Pioneer of prostate cancer: past, present and the future of FOXA1	81
Mouse-adapted SARS-CoV-2 replicates efficiently in the upper and lower respiratory tract of BALB/c and C57BL/6J mice	75
RIP1-dependent linear and nonlinear recruitments of caspase-8 and RIP3 respectively to necrosome specify distinct cell death outcomes	75
Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients	71
Role of gut microbiota in identification of novel TCM-derived active metabolites	69
KIF2C: a novel link between Wnt/β-catenin and mTORC1 signaling in the pathogenesis of hepatocellular carcinoma	68
Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection	66

Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model	65
Gut microbes in cardiovascular diseases and their potential therapeutic applications	62
The mini player with diverse functions: extracellular vesicles in cell biology, disease, and therapeutics	62
Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling	60
TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2	53
The function and regulation of TET2 in innate immunity and inflammation	50
Gut microbiota alterations are distinct for primary colorectal cancer and hepatocellular carcinoma	50
Lipids and membrane-associated proteins in autophagy	48
Single-nucleus transcriptomic landscape of primate hippocampal aging	46
Generation of a Hutchinson–Gilford progeria syndrome monkey model by base editing	43
Live cell imaging and proteomic profiling of endogenous NEAT1 lncRNA by CRISPR/Cas9-mediated knock-in	41
Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation	41
Sirt1 regulates testosterone biosynthesis in Leydig cells via modulating autophagy	40
Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis	40
Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development	40
Role of glycosylation in TGF-β signaling and epithelial-to-mesenchymal transition in cancer	39
Cytochrome P450 reductase (POR) as a ferroptosis fuel	39
Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis	35
PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis	33
Pan-coronavirus fusion inhibitors as the hope for today and tomorrow	31
Structure of intact human MCU supercomplex with the auxiliary MICU subunits	31
Nuclear cGAS: sequestration and beyond	30
Re-detectable positive SARS-CoV-2 RNA tests in patients who recovered from COVID-19 with intestinal infection	29
POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation	28
Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2	27
A pair of transporters controls mitochondrial Zn2+ levels to maintain mitochondrial homeostasis	27
FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocardial infarction	27
FAK-targeting PROTAC as a chemical tool for the investigation of non-enzymatic FAK function in mice	26
Therapeutic silencing miR-146b-5p improves cardiac remodeling in a porcine model of myocardial infarction by modulating the wound reparative phenotype	26
Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response	26
Higher-order assemblies in immune signaling: supramolecular complexes and phase separation	25
An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope	25
3D chromatin architecture and epigenetic regulation in cancer stem cells	25
Single cell RNA and immune repertoire profiling of COVID-19 patients reveal novel neutralizing antibody	25
O-GlcNAc transferase regulates centriole behavior and intraflagellar transport to promote ciliogenesis	23
Deciphering primate retinal aging at single-cell resolution	23
The p21-activated kinases in neural cytoskeletal remodeling and related neurological disorders	23
Broad spectrum antibiotic-degrading metallo-β-lactamases are phylogenetically diverse	20
Structural insights into the activation initiation of full-length mGlu1	20
Histone deacetylase 3 promotes innate antiviral immunity through deacetylation of TBK1	19
Cancer biology deciphered by single-cell transcriptomic sequencing	19
Precise genome editing without exogenous donor DNA via retron editing system in human cells	19
METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth	19
cGAS guards against chromosome end-to-end fusions during mitosis and facilitates replicative senescence	18
The exploration of N6-deoxyadenosine methylation in mammalian genomes	18
Loss of 4.1N in epithelial ovarian cancer results in EMT and matrix-detached cell death resistance	17
The best practice for microbiome analysis using R	17
Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase	17