OOIR: Observatory of International Research

Papers

(The TQCC of Pharmacological Reports is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Acknowledgments	77
Safety of non-standard regimen of systemic steroid therapy in patients with Graves’ orbitopathy: a single-centre experience	73
A derivative of 3-(1,3-diarylallylidene)oxindoles inhibits dextran sulfate sodium-induced colitis in mice	71
Correction to: The impact of IL-10 and CYP3A5 gene polymorphisms on dose-adjusted trough blood tacrolimus concentrations in early post-renal transplant recipients	69
The KCNQ channel inhibitor XE991 suppresses nicotinic acetylcholine receptor-mediated responses in rat intracardiac ganglion neurons	57
The effect of poly I:C or LPS priming on the therapeutic efficacy of mesenchymal stem cells in an adjuvant-induced arthritis rat model	56
Hypoxia-inducible factors and essential hypertension: narrative review of experimental and clinical data	49
The influence of preconditioning with low dose of LPS on paraquat-induced neurotoxicity, microglia activation and expression of α-synuclein and synphilin-1 in the dopaminergic system	48
Iodothyronine deiodinases in patients with stable chronic obstructive pulmonary disease - preliminary results	41
Potential drugs for the treatment of Alzheimer’s disease	38
FNF-12, a novel benzylidene-chromanone derivative, attenuates inflammatory response in in vitro and in vivo asthma models mediated by M2-related Th2 cytokines via MAPK and NF-kB signaling	37
Luteolin for neurodegenerative diseases: a review	36
The study of platelet aggregation using a microtiter plate reader ‒ methodological considerations	36
Note from editors	36
Assessing the effects of 5-HT2A and 5-HT5A receptor antagonists on DOI-induced head-twitch response in male rats using marker-less deep learning algorithms	35
β-Carboline derivatives are potent against Acute Myeloid Leukemia in vitro and in vivo	35
Novel method of measurement of in vitro drug uptake in OATP1B3 overexpressing cells in the presence of dextran	33
Padsevonil suppresses seizures without inducing cell death in neonatal rats	29
Real-world experience with direct-acting antiviral therapy in HCV-infected patients with cirrhosis and esophageal varices	29
Genetic liability for anxiety and treatment response to the monoamine stabilizer OSU6162 in alcohol dependence: a retrospective secondary analysis	28
Evaluation of nano-curcumin against inhaled paraquat-induced lung injury in rats	27
Effect of vitamin D supplementation on OPG/RANKL signalling activities in endothelial tissue damage in diet-induced diabetic rat model	26
The ixabepilone and vandetanib combination shows synergistic activity in docetaxel-resistant MDA-MB-231 breast cancer cells	25
Association analysis of ADRB3:rs4994 with urodynamic outcome, six months after a single intra-detrusor injection of botulinum toxin, in women with overactive bladder	24
The possible pathogenesis of liver fibrosis: therapeutic potential of natural polyphenols	23

Novel receptor tyrosine kinase-targeted strategies to overcome resistance in oral squamous cell carcinoma	23
Carvacrol in asthma management: a comprehensive review of its therapeutic potential and mechanisms of action	23
The impact of noradrenergic neurotoxin DSP-4 and noradrenaline transporter knockout (NET-KO) on the activity of liver cytochrome P450 3A (CYP3A) in male and female mice	23
Pten knockout affects drug resistance differently in melanoma and kidney cancer	23
Dietary phytochemicals/nutrients as promising protector of breast cancer development: a comprehensive analysis	23
A review of serious adverse events linked with GLP-1 agonists in type 2 diabetes mellitus and obesity treatment	22
The potential action of SSRIs in the treatment of skin diseases including atopic dermatitis and slow-healing wounds	21
Vortioxetine liposomes as a novel alternative to improve drug stability under stress conditions: toxicity studies and evaluation of antidepressant-like effect	21
Preclinical efficacy of cannabidiol for the treatment of early-life seizures	21
Olanzapine alters the expression of gasotransmitter-related enzymes: CBS and HO-2 in the rat hippocampus and striatum	20
Comprehensive evaluation of ibuprofenate amino acid isopropyl esters: insights into antioxidant activity, cytocompatibility, and cyclooxygenase inhibitory potential	18
Liquid chromatography–tandem mass spectrometry method for mycophenolic acid and its glucuronide determination in saliva samples from children with nephrotic syndrome	18
The therapeutic potential of vitamin D supplementation in asthma	18
Evaluation of the 5-HT2C receptor drugs RO 60-0175, WAY 161503 and mirtazepine in a preclinical model of comorbidity of depression and cocaine addiction	17
Comparative study of the binding between chlorogenic acid and four proteins by isothermal titration calorimetry, spectroscopy and docking methods	17
Early plasma changes of HIF-1 alpha, matrix metalloproteinases-2 and − 9, and tissue inhibitor of matrix metalloproteinase-1 in patients with infantile hemangiomas treated with propranolol	16
The association of the quality of sleep with proinflammatory cytokine profile in inflammatory bowel disease patients	15
JR-AB2-011 induces fast metabolic changes independent of mTOR complex 2 inhibition in human leukemia cells	14
Group III metabotropic glutamate receptors: guardians against excitotoxicity in ischemic brain injury, with implications for neonatal contexts	14
Activation of 5-HT7 receptors in the mouse dentate gyrus does not affect theta-burst-induced plasticity at the perforant path synapse	14
Essential phospholipids impact cytokine secretion and alter lipid-metabolizing enzymes in human hepatocyte cell lines	14
Agonistic properties of a series of psychotropic drugs at 5-HT1A receptors in rat and human brain membranes determined by [35S]GTPγS binding assay	14
Red cell microparticles produced using high-pressure extrusion enhance both primary and secondary hemostasis	14
The roles of cellular protease interactions in viral infections and programmed cell death: a lesson learned from the SARS-CoV-2 outbreak and COVID-19 pandemic	13
Retraction Note to: Anti-inflammatory role of leptin in glial cells through p38 MAPK pathway inhibition	12
A novel 2-oxopyrrolidine derivative (LN-53) efficiently induces Nrf-2 signaling pathway activation in human epidermal keratinocytes	12
Correction: Access to high-fat diet results in increased sensitivity to the psychostimulant effects of MDPV in mice	12
The effect of new atypical antipsychotic drugs on the expression of transcription factors regulating cytochrome P450 enzymes in rat liver	12
Antiviral drug research for Japanese encephalitis: an updated review	12
The effects of the recurrent social isolation stress on fear extinction and dopamine D2 receptors in the amygdala and the hippocampus	11
KM-408, a novel phenoxyalkyl derivative as a potential anticonvulsant and analgesic compound for the treatment of neuropathic pain	11
Interaction of hallucinogenic rapid-acting antidepressants with mGlu2/3 receptor ligands as a window for more effective therapies	11
Melatonin increases collagen content accumulation and Fibroblast Growth Factor-2 secretion in cultured human cardiac fibroblasts	11
Correction: Compound PZ-1262, a 4-isoquinoline-sulfonamide analog of Brexpiprazole, produces potential antidepressant, anxiolytic and procognitive effects in rodent models	10
Interactions of antidepressants with concomitant medications—safety of complex therapies in multimorbidities	10
Role of the β2-adrenergic receptor in podocyte injury and recovery	10
Redox homeostasis in human renal cells that had been treated with amphotericin B in combination with selected 1,3,4-thiadiazole derivatives	10
Nanoparticles coated by chloramphenicol in hydrogels as a useful tool to increase the antibiotic release and antibacterial activity in dermal drug delivery	10
MDPV (3,4-methylenedioxypyrovalerone) administered to mice during development of the central nervous system produces persistent learning and memory impairments	10
Colonic inflammation induces changes in glucose levels through modulation of incretin system	10
Plant-derived immuno-adjuvants in vaccines formulation: a promising avenue for improving vaccines efficacy against SARS-CoV-2 virus	9
Advances in the anti-tumor mechanisms of saikosaponin D	9
Lymphopenia associated with sphingosine 1-phosphate receptor modulators (S1PRMs) in multiple sclerosis: analysis of European pharmacovigilance data	9
Metabotropic glutamate receptors—guardians and gatekeepers in neonatal hypoxic-ischemic brain injury	9
A re-consideration of neural/receptor mechanisms in chemotherapy-induced nausea and vomiting: current scenario and future perspective	9
Access to high-fat diet results in increased sensitivity to the psychostimulant effects of MDPV in mice	9
Correction: Marizomib in the therapy of brain tumors—how far did we go and where do we stand?	9
Identification of mitogen-activated protein kinase phosphatase-1 (MKP-1) protein partners using tandem affinity purification and mass spectrometry	9
Cannabinoids in the treatment of glioblastoma	9
Synthetic free fatty acid receptor (FFAR) 2 agonist 4-CMTB and FFAR4 agonist GSK13764 inhibit colon cancer cell growth and migration and regulate FFARs expression in in vitro and in vivo models of col	9

Extracellular acidification reveals the antiarrhythmic properties of amiodarone related to late sodium current-induced atrial arrhythmia	9
Recent review of COVID-19 management: diagnosis, treatment and vaccination	9
Gαi-derived peptide binds the µ-opioid receptor	8
Radiosensitizing effect of dendrosomal nanoformulation of curcumin on cancer cells	8
Cobalt protoporphyrin IX induces transient, dose- and time-dependent granulocyte mobilization with mild metabolic effects in mice	8
Mitochondrial targeted antioxidants as potential therapy for huntington’s disease	8
Efficacy of COVID-19 vaccines: a systematic review and network meta-analysis of phase 3 randomized controlled trials	8
Regulatory effects of resveratrol on nitric oxide signaling in cardiovascular diseases	8
High-performance liquid chromatography with fluorescence detection for mycophenolic acid determination in saliva samples	8
Investigating whether alcohol is transformed to norepinephrine or dopamine in the mouse brain	8
Multiple sclerosis: a narrative overview of current pharmacotherapies and emerging treatment prospects	8
Transcriptome analysis of an AKT inhibitor-resistant endometrial cancer cell line	8
Identification of genes regulated by trait sensitivity to negative feedback and prolonged alcohol consumption in rats	8
Insulin in combination with pioglitazone prevents advanced cachexia in 256-Walker tumor-bearing rats: effect is greater than treatment alone and is associated with improved insulin sensitivity	8
Acetaminophen treatment evokes anticontractile effects in rat aorta by blocking L-type calcium channels	8
Saliva as a matrix for therapeutic drug monitoring and disease biomarkers in children and adolescents	7
Psilocybin and the glutamatergic pathway: implications for the treatment of neuropsychiatric diseases	7
Impact of levetiracetam and ethanol on memory, selected neurotransmitter levels, oxidative stress parameters, and essential elements in rats	7
Acyclic sesquiterpenes nerolidol and farnesol: mechanistic insights into their neuroprotective potential	7
JG26 attenuates ADAM17 metalloproteinase-mediated ACE2 receptor processing and SARS-CoV-2 infection in vitro	7
Association between gene polymorphisms and initial warfarin therapy in patients after heart valve surgery	7
A single dose of haloperidol decanoate induces short-term hippocampal neuroinflammation: focus on the glial response	7
Correction to: Selective cytotoxic and genotoxic activities of 5-(2-bromo-5- methoxybenzylidene)-thiazolidine-2,4-dione against NCI-H292 human lung carcinoma cells	7
Atorvastatin attenuates the expression of damage-associated molecular patterns and inflammatory cytokines in patients with psoriasis	7
New gold(III) complexes TGS 121, 404, and 702 show anti-tumor activity in colitis-induced colorectal cancer: an in vitro and in vivo study	7
Combined effects of HCRTR1/2 gene variants and non-genetic factors on sleep-wake transition and hemodynamic stability during propofol, dexmedetomidine, and remifentanil anesthesia	7
Anti-nociceptive potential of an isatin-derived dual fatty acid amide hydrolase-monoacylglycerol lipase inhibitor	7
The effect of valproate on the amino acids, monoamines, and kynurenic acid concentrations in brain structures involved in epileptogenesis in the pentylenetetrazol-kindled rats	7
Correction to: Radiosensitizing effect of dendrosomal nanoformulation of curcumin on cancer cells	7
Evaluation of anti-inflammatory response of berberine-loaded gum nanocomplexes in carrageenan-induced acute paw edema in rats	7
Effect of 28 days treatment of baricitinib on mechanical allodynia, osteopenia, and loss of nerve fibers in an experimental model of type-1 diabetes mellitus	7
Ethanol deprivation and central 5-HT deficiency differentially affect the mRNA editing of the 5-HT2C receptor in the mouse brain	7
Protective effect of hygrolansamycin C against corticosterone-induced toxicity and oxidative stress-mediated via autophagy and the MAPK signaling pathway	7
Effects of N-acetylcysteine and acetyl-l-carnitine on acute PTZ-induced seizures in larval and adult zebrafish	7
Suppression of nitric oxide synthase aggravates non-alcoholic steatohepatitis and atherosclerosis in SHRSP5/Dmcr rat via acceleration of abnormal lipid metabolism	7
The impact of muscarinic and mGlu receptors modulators on MK-801-induced impairments in NO-dependent processes both in vitro and in vivo	7
DPP-4 inhibitors and type 2 diabetes mellitus in Parkinson’s disease: a mutual relationship	7
Inhibitory effect of atomoxetine on Nav1.2 voltage-gated sodium channel currents	7
Preclinical evaluation of a microtubule PET ligand [11C]MPC-6827 in tau and amyotrophic lateral sclerosis animal models	7
Effects of magnolol on the liver antioxidant status in rats with diabetes	7
Interactions of fentanyl with blood platelets and plasma proteins: platelet sensitivity to prasugrel metabolite is not affected by fentanyl under in vitro conditions	7
Cannabidiol may prevent the development of congestive hepatopathy secondary to right ventricular hypertrophy associated with pulmonary hypertension in rats	7