OOIR: Observatory of International Research

Papers

(The TQCC of Pharmacological Reports is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Correction to: The impact of IL-10 and CYP3A5 gene polymorphisms on dose-adjusted trough blood tacrolimus concentrations in early post-renal transplant recipients	83
The KCNQ channel inhibitor XE991 suppresses nicotinic acetylcholine receptor-mediated responses in rat intracardiac ganglion neurons	78
Safety of non-standard regimen of systemic steroid therapy in patients with Graves’ orbitopathy: a single-centre experience	74
A derivative of 3-(1,3-diarylallylidene)oxindoles inhibits dextran sulfate sodium-induced colitis in mice	69
Hypoxia-inducible factors and essential hypertension: narrative review of experimental and clinical data	67
Acknowledgments	59
The effect of poly I:C or LPS priming on the therapeutic efficacy of mesenchymal stem cells in an adjuvant-induced arthritis rat model	56
Potential drugs for the treatment of Alzheimer’s disease	53
Iodothyronine deiodinases in patients with stable chronic obstructive pulmonary disease - preliminary results	44
Luteolin for neurodegenerative diseases: a review	41
The influence of preconditioning with low dose of LPS on paraquat-induced neurotoxicity, microglia activation and expression of α-synuclein and synphilin-1 in the dopaminergic system	41
Note from editors	40
Padsevonil suppresses seizures without inducing cell death in neonatal rats	40
Novel method of measurement of in vitro drug uptake in OATP1B3 overexpressing cells in the presence of dextran	40
Genetic liability for anxiety and treatment response to the monoamine stabilizer OSU6162 in alcohol dependence: a retrospective secondary analysis	40
Evaluation of nano-curcumin against inhaled paraquat-induced lung injury in rats	39
The study of platelet aggregation using a microtiter plate reader ‒ methodological considerations	35
Real-world experience with direct-acting antiviral therapy in HCV-infected patients with cirrhosis and esophageal varices	32
Assessing the effects of 5-HT2A and 5-HT5A receptor antagonists on DOI-induced head-twitch response in male rats using marker-less deep learning algorithms	30
Pten knockout affects drug resistance differently in melanoma and kidney cancer	29
β-Carboline derivatives are potent against Acute Myeloid Leukemia in vitro and in vivo	29
The ixabepilone and vandetanib combination shows synergistic activity in docetaxel-resistant MDA-MB-231 breast cancer cells	29
Association analysis of ADRB3:rs4994 with urodynamic outcome, six months after a single intra-detrusor injection of botulinum toxin, in women with overactive bladder	28
The possible pathogenesis of liver fibrosis: therapeutic potential of natural polyphenols	26
The impact of noradrenergic neurotoxin DSP-4 and noradrenaline transporter knockout (NET-KO) on the activity of liver cytochrome P450 3A (CYP3A) in male and female mice	26

Dietary phytochemicals/nutrients as promising protector of breast cancer development: a comprehensive analysis	25
Novel receptor tyrosine kinase-targeted strategies to overcome resistance in oral squamous cell carcinoma	25
Carvacrol in asthma management: a comprehensive review of its therapeutic potential and mechanisms of action	25
Genetic variants in GRIN2B and NTRK2 on the etiology and treatment response to valproate and lithium in patients with bipolar disorder	24
The potential action of SSRIs in the treatment of skin diseases including atopic dermatitis and slow-healing wounds	24
The therapeutic potential of vitamin D supplementation in asthma	23
Preclinical efficacy of cannabidiol for the treatment of early-life seizures	23
A review of serious adverse events linked with GLP-1 agonists in type 2 diabetes mellitus and obesity treatment	23
Liquid chromatography–tandem mass spectrometry method for mycophenolic acid and its glucuronide determination in saliva samples from children with nephrotic syndrome	21
Early plasma changes of HIF-1 alpha, matrix metalloproteinases-2 and − 9, and tissue inhibitor of matrix metalloproteinase-1 in patients with infantile hemangiomas treated with propranolol	20
Comprehensive evaluation of ibuprofenate amino acid isopropyl esters: insights into antioxidant activity, cytocompatibility, and cyclooxygenase inhibitory potential	19
Vortioxetine liposomes as a novel alternative to improve drug stability under stress conditions: toxicity studies and evaluation of antidepressant-like effect	19
Olanzapine alters the expression of gasotransmitter-related enzymes: CBS and HO-2 in the rat hippocampus and striatum	19
Comparative study of the binding between chlorogenic acid and four proteins by isothermal titration calorimetry, spectroscopy and docking methods	18
The role of microbiota modulation in preventing Alzheimer’s disease- a review	17
Palbociclib in endocrine-resistant metastatic breast cancer patients: gene polymorphism- based study	17
Evaluation of the 5-HT2C receptor drugs RO 60-0175, WAY 161503 and mirtazepine in a preclinical model of comorbidity of depression and cocaine addiction	17
Agonistic properties of a series of psychotropic drugs at 5-HT1A receptors in rat and human brain membranes determined by [35S]GTPγS binding assay	16
JR-AB2-011 induces fast metabolic changes independent of mTOR complex 2 inhibition in human leukemia cells	16
Activation of 5-HT7 receptors in the mouse dentate gyrus does not affect theta-burst-induced plasticity at the perforant path synapse	16
The roles of cellular protease interactions in viral infections and programmed cell death: a lesson learned from the SARS-CoV-2 outbreak and COVID-19 pandemic	15
Red cell microparticles produced using high-pressure extrusion enhance both primary and secondary hemostasis	15
Involvement of uridine in brain and gut health: insights into its neuroprotective potential via the gut-brain axis	15
MIM1 – a selective Mcl-1 protein inhibitor augments the proapoptotic activity of moxifloxacin toward MDA-MB-231 triple-negative breast cancer cells – a preliminary in vitro study	14
Antiviral drug research for Japanese encephalitis: an updated review	14
Group III metabotropic glutamate receptors: guardians against excitotoxicity in ischemic brain injury, with implications for neonatal contexts	13
Correction: Access to high-fat diet results in increased sensitivity to the psychostimulant effects of MDPV in mice	13
A novel 2-oxopyrrolidine derivative (LN-53) efficiently induces Nrf-2 signaling pathway activation in human epidermal keratinocytes	13
Synthesis and evaluation of KR-12, an LL-37 fragment, and its short-chain fatty acid derivatives: selective cytotoxicity in colorectal cancer cells and anti-tumor efficacy in an azoxymethane/DSS-induc	13
Essential phospholipids impact cytokine secretion and alter lipid-metabolizing enzymes in human hepatocyte cell lines	13
The effect of new atypical antipsychotic drugs on the expression of transcription factors regulating cytochrome P450 enzymes in rat liver	11
Retraction Note to: Anti-inflammatory role of leptin in glial cells through p38 MAPK pathway inhibition	11
KM-408, a novel phenoxyalkyl derivative as a potential anticonvulsant and analgesic compound for the treatment of neuropathic pain	11
Interaction of hallucinogenic rapid-acting antidepressants with mGlu2/3 receptor ligands as a window for more effective therapies	11
Peptide-based strategies for overcoming taxol-resistance in cancer therapy – a narrative review	11
The effects of the recurrent social isolation stress on fear extinction and dopamine D2 receptors in the amygdala and the hippocampus	11
Melatonin increases collagen content accumulation and Fibroblast Growth Factor-2 secretion in cultured human cardiac fibroblasts	11
MDPV (3,4-methylenedioxypyrovalerone) administered to mice during development of the central nervous system produces persistent learning and memory impairments	11
Interactions of antidepressants with concomitant medications—safety of complex therapies in multimorbidities	10
Role of the β2-adrenergic receptor in podocyte injury and recovery	10
Advances in the anti-tumor mechanisms of saikosaponin D	10
Correction: Compound PZ-1262, a 4-isoquinoline-sulfonamide analog of Brexpiprazole, produces potential antidepressant, anxiolytic and procognitive effects in rodent models	10
Synthetic free fatty acid receptor (FFAR) 2 agonist 4-CMTB and FFAR4 agonist GSK13764 inhibit colon cancer cell growth and migration and regulate FFARs expression in in vitro and in vivo models of col	10
A re-consideration of neural/receptor mechanisms in chemotherapy-induced nausea and vomiting: current scenario and future perspective	10
Multiple sclerosis: a narrative overview of current pharmacotherapies and emerging treatment prospects	9
Plant-derived immuno-adjuvants in vaccines formulation: a promising avenue for improving vaccines efficacy against SARS-CoV-2 virus	9
Nanoparticles coated by chloramphenicol in hydrogels as a useful tool to increase the antibiotic release and antibacterial activity in dermal drug delivery	9
Identification of mitogen-activated protein kinase phosphatase-1 (MKP-1) protein partners using tandem affinity purification and mass spectrometry	9
Recent review of COVID-19 management: diagnosis, treatment and vaccination	9
Access to high-fat diet results in increased sensitivity to the psychostimulant effects of MDPV in mice	9

Cannabinoids in the treatment of glioblastoma	9
The cortisol axis and psychiatric disorders: an updated review	9
Metabotropic glutamate receptors—guardians and gatekeepers in neonatal hypoxic-ischemic brain injury	9
Lymphopenia associated with sphingosine 1-phosphate receptor modulators (S1PRMs) in multiple sclerosis: analysis of European pharmacovigilance data	9
Redox homeostasis in human renal cells that had been treated with amphotericin B in combination with selected 1,3,4-thiadiazole derivatives	9
Extracellular acidification reveals the antiarrhythmic properties of amiodarone related to late sodium current-induced atrial arrhythmia	9
Correction: Marizomib in the therapy of brain tumors—how far did we go and where do we stand?	9
Mitochondrial targeted antioxidants as potential therapy for huntington’s disease	8
Anti-nociceptive potential of an isatin-derived dual fatty acid amide hydrolase-monoacylglycerol lipase inhibitor	8
Acetaminophen treatment evokes anticontractile effects in rat aorta by blocking L-type calcium channels	8
Cobalt protoporphyrin IX induces transient, dose- and time-dependent granulocyte mobilization with mild metabolic effects in mice	8
Radiosensitizing effect of dendrosomal nanoformulation of curcumin on cancer cells	8
Regulatory effects of resveratrol on nitric oxide signaling in cardiovascular diseases	8
The impact of muscarinic and mGlu receptors modulators on MK-801-induced impairments in NO-dependent processes both in vitro and in vivo	8
Effects of N-acetylcysteine and acetyl-l-carnitine on acute PTZ-induced seizures in larval and adult zebrafish	8
Insulin in combination with pioglitazone prevents advanced cachexia in 256-Walker tumor-bearing rats: effect is greater than treatment alone and is associated with improved insulin sensitivity	8
Transcriptome analysis of an AKT inhibitor-resistant endometrial cancer cell line	8
Identification of genes regulated by trait sensitivity to negative feedback and prolonged alcohol consumption in rats	8
Efficacy of COVID-19 vaccines: a systematic review and network meta-analysis of phase 3 randomized controlled trials	8
Inhibitory effect of atomoxetine on Nav1.2 voltage-gated sodium channel currents	8
Investigating whether alcohol is transformed to norepinephrine or dopamine in the mouse brain	8
High-performance liquid chromatography with fluorescence detection for mycophenolic acid determination in saliva samples	8
The effect of valproate on the amino acids, monoamines, and kynurenic acid concentrations in brain structures involved in epileptogenesis in the pentylenetetrazol-kindled rats	8
DPP-4 inhibitors and type 2 diabetes mellitus in Parkinson’s disease: a mutual relationship	8
Gαi-derived peptide binds the µ-opioid receptor	8
Suppression of nitric oxide synthase aggravates non-alcoholic steatohepatitis and atherosclerosis in SHRSP5/Dmcr rat via acceleration of abnormal lipid metabolism	7
Solcumin™: a functional hybrid particle with potent anti-inflammatory and antioxidant activities and enhanced storage stability	7
Correction to: Selective cytotoxic and genotoxic activities of 5-(2-bromo-5- methoxybenzylidene)-thiazolidine-2,4-dione against NCI-H292 human lung carcinoma cells	7
Impact of levetiracetam and ethanol on memory, selected neurotransmitter levels, oxidative stress parameters, and essential elements in rats	7
Decreased efficacy of the ketamine and scopolamine-induced sustained antidepressant-like effects in rats receiving metformin	7
Effect of 28 days treatment of baricitinib on mechanical allodynia, osteopenia, and loss of nerve fibers in an experimental model of type-1 diabetes mellitus	7
Cannabidiol may prevent the development of congestive hepatopathy secondary to right ventricular hypertrophy associated with pulmonary hypertension in rats	7
Psilocybin and the glutamatergic pathway: implications for the treatment of neuropsychiatric diseases	7
Saliva as a matrix for therapeutic drug monitoring and disease biomarkers in children and adolescents	7
Atorvastatin attenuates the expression of damage-associated molecular patterns and inflammatory cytokines in patients with psoriasis	7
A single dose of haloperidol decanoate induces short-term hippocampal neuroinflammation: focus on the glial response	7
Preclinical evaluation of a microtubule PET ligand [11C]MPC-6827 in tau and amyotrophic lateral sclerosis animal models	7
New gold(III) complexes TGS 121, 404, and 702 show anti-tumor activity in colitis-induced colorectal cancer: an in vitro and in vivo study	7
Ethanol deprivation and central 5-HT deficiency differentially affect the mRNA editing of the 5-HT2C receptor in the mouse brain	7
JG26 attenuates ADAM17 metalloproteinase-mediated ACE2 receptor processing and SARS-CoV-2 infection in vitro	7
Acyclic sesquiterpenes nerolidol and farnesol: mechanistic insights into their neuroprotective potential	7
Combined effects of HCRTR1/2 gene variants and non-genetic factors on sleep-wake transition and hemodynamic stability during propofol, dexmedetomidine, and remifentanil anesthesia	7
Effects of magnolol on the liver antioxidant status in rats with diabetes	7
Evaluation of anti-inflammatory response of berberine-loaded gum nanocomplexes in carrageenan-induced acute paw edema in rats	7
Association between gene polymorphisms and initial warfarin therapy in patients after heart valve surgery	7
Interactions of fentanyl with blood platelets and plasma proteins: platelet sensitivity to prasugrel metabolite is not affected by fentanyl under in vitro conditions	7
Correction to: Radiosensitizing effect of dendrosomal nanoformulation of curcumin on cancer cells	7
Protective effect of hygrolansamycin C against corticosterone-induced toxicity and oxidative stress-mediated via autophagy and the MAPK signaling pathway	7