OOIR: Observatory of International Research

Papers

(The TQCC of Pharmacological Reports is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Drug repurposing approach to fight COVID-19	309
Drug resistance in cancer: mechanisms and tackling strategies	125
Overview of the possible role of vitamin C in management of COVID-19	77
Chemotherapy-induced peripheral neuropathy: part 1—current state of knowledge and perspectives for pharmacotherapy	72
Cepharanthine: a review of the antiviral potential of a Japanese-approved alopecia drug in COVID-19	69
Role of oxidative stress in epileptogenesis and potential implications for therapy	66
Ivermectin as a potential drug for treatment of COVID-19: an in-sync review with clinical and computational attributes	59
Thiadiazole derivatives as anticancer agents	52
Pharmacological properties of baicalin on liver diseases: a narrative review	51
Ketamine—50 years in use: from anesthesia to rapid antidepressant effects and neurobiological mechanisms	50
Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention	48
Ciprofloxacin and moxifloxacin could interact with SARS-CoV-2 protease: preliminary in silico analysis	45
Muscle and cardiac therapeutic strategies for Duchenne muscular dystrophy: past, present, and future	45
In-hospital use of statins is associated with a reduced risk of mortality in coronavirus-2019 (COVID-19): systematic review and meta-analysis	44
Recent review of COVID-19 management: diagnosis, treatment and vaccination	41
Effects of curcumin on neurological diseases: focus on astrocytes	40
Advances in targeting EGFR allosteric site as anti-NSCLC therapy to overcome the drug resistance	40
Neurotrophic factors for disease-modifying treatments of Parkinson's disease: gaps between basic science and clinical studies	39
Neurotoxic effects of aluminium exposure as a potential risk factor for Alzheimer’s disease	39
Efflux pump inhibitors: new updates	38
Comparing efficacy and safety of different doses of dexamethasone in the treatment of COVID-19: a three-arm randomized clinical trial	36
A pilot study on intravenous N-Acetylcysteine treatment in patients with mild-to-moderate COVID19-associated acute respiratory distress syndrome	35
STAT3 transcription factor as target for anti-cancer therapy	34
Altered glucose metabolism and insulin resistance in cancer-induced cachexia: a sweet poison	33
Pharmacological treatments of COVID-19	33

Recent progress in biologically active indole hybrids: a mini review	33
Oral antiviral treatments for COVID-19: opportunities and challenges	33
Mechanistic insight on the role of leukotriene receptors in ischemic–reperfusion injury	32
Role of pirfenidone in TGF-β pathways and other inflammatory pathways in acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: a theoretical perspective	31
Effects and mechanisms of phthalates’ action on neurological processes and neural health: a literature review	31
Intestinal drug transporters in pathological states: an overview	30
Observational study of people infected with SARS-Cov-2, treated with amantadine	30
Formyl peptide receptor 2, as an important target for ligands triggering the inflammatory response regulation: a link to brain pathology	29
Molecular insights into the therapeutic promise of targeting HMGB1 in depression	27
Endogenous estrogens—breast cancer and chemoprevention	27
Insights into a possible role of glucagon-like peptide-1 receptor agonists in the treatment of depression	27
Magnetic resonance diffusion tensor imaging in psychiatry: a narrative review of its potential role in diagnosis	26
Anti-inflammatory activity of novel thiosemicarbazone compounds indole-based as COX inhibitors	25
Thymol induces mitochondrial pathway-mediated apoptosis via ROS generation, macromolecular damage and SOD diminution in A549 cells	25
Ginsenoside from ginseng: a promising treatment for inflammatory bowel disease	24
Neuroprotection through G-CSF: recent advances and future viewpoints	24
A review of the mechanisms underlying selected comorbidities in Alzheimer’s disease	23
Kynurenine pathway in kidney diseases	23
Clinical significance of fluid biomarkers in Alzheimer’s Disease	23
Targeting the CCL2-CCR2 axis in depressive disorders	22
Real-world experience with molnupiravir during the period of SARS-CoV-2 Omicron variant dominance	22
The association between the use of ivermectin and mortality in patients with COVID-19: a meta-analysis	21
Altered expression of cytochrome P450 enzymes involved in metabolism of androgens and vitamin D in the prostate as a risk factor for prostate cancer	21
Pruritus in psoriasis and atopic dermatitis: current treatments and new perspectives	21
Tideglusib attenuates growth of neuroblastoma cancer stem/progenitor cells in vitro and in vivo by specifically targeting GSK-3β	19
Disulfiram potentiates docetaxel cytotoxicity in breast cancer cells through enhanced ROS and autophagy	19
Update on the neurodevelopmental theory of depression: is there any ‘unconscious code’?	18
Influence of metformin on HIF-1 pathway in multiple myeloma	18
The selective cytotoxicity of silver thiosulfate, a silver complex, on MCF-7 breast cancer cells through ROS-induced cell death	18
The Warburg effect: a score for many instruments in the concert of cancer and cancer niche cells	18
Cannabinoid-based therapy as a future for joint degeneration. Focus on the role of CB2 receptor in the arthritis progression and pain: an updated review	17
Amantadine in the prevention of clinical symptoms caused by SARS-CoV-2	17
Relationship between thyroid hormones and central nervous system metabolism in physiological and pathological conditions	17
SARS-CoV-2 therapeutics: how far do we stand from a remedy?	17
Chronic hyperglycemia impairs mitochondrial unfolded protein response and precipitates proteotoxicity in experimental diabetic neuropathy: focus on LonP1 mediated mitochondrial regulation	17
Favipiravir use for SARS CoV-2 infection	16
Modulating role of serotonergic signaling in sleep and memory	16
Alcohol and breast cancer	16
JNK signaling as a target for anticancer therapy	16
Mechanistic interplay of various mediators involved in mediating the neuroprotective effect of daphnetin	15
The immunosuppressive effect of the endocannabinoid system on the inflammatory phenotypes of macrophages and mesenchymal stromal cells: a comparative study	15
A novel plausible mechanism of NSAIDs-induced apoptosis in cancer cells: the implication of proline oxidase and peroxisome proliferator-activated receptor	15
Sleep improvement is associated with the antidepressant efficacy of repeated-dose ketamine and serum BDNF levels: a post-hoc analysis	15
Targeting HIF-1α by newly synthesized Indolephenoxyacetamide (IPA) analogs to induce anti-angiogenesis-mediated solid tumor suppression	14
Rifampicin and Letermovir as potential repurposed drug candidate for COVID-19 treatment: insights from an in-silico study	14
End-stage renal disease reduces the expression of drug-metabolizing cytochrome P450s	14
Pharmacokinetics and tissue distribution of hydrazinocurcumin in rats	14
Reporting statistical methods and outcome of statistical analyses in research articles	14
Evaluation of some thiophene-based sulfonamides as potent inhibitors of carbonic anhydrase I and II isoenzymes isolated from human erythrocytes by kinetic and molecular modelling studies	14
A review of the effects of ticagrelor on adenosine concentration and its clinical significance	14

Nasal sprays for treating COVID-19: a scientific note	14
Proton pump inhibitor on susceptibility to COVID-19 and its severity: a systematic review and meta-analysis	14
Neurological consequences of COVID-19	13
Analgesic effects of the CTK 01512-2 toxin in different models of orofacial pain in rats	13
The role of brain gaseous neurotransmitters in anxiety	13
Antidepressant-like effect of dehydrozingerone from Zingiber officinale by elevating monoamines in brain: in silico and in vivo studies	13
Berberine and its derivatives represent as the promising therapeutic agents for inflammatory disorders	13
Fenofibrate ameliorates testicular damage in rats with streptozotocin-induced type 1 diabetes: role of HO-1 and p38 MAPK	13
N-acetylcysteine in substance use disorder: a lesson from preclinical and clinical research	13
Short-chain fatty acids–microbiota crosstalk in the coronavirus disease (COVID-19)	13
The potential use of tideglusib as an adjuvant radio-therapeutic treatment for glioblastoma multiforme cancer stem-like cells	12
The effect of alpha lipoic acid on passive avoidance and social interaction memory, pain perception, and locomotor activity in REM sleep-deprived rats	12
Evaluation of curcumin-loaded polymeric nanocapsules with different coatings in chick embryo model: influence on angiogenesis, teratogenesis and oxidative stress	12
Chemical chaperones targeted to the endoplasmic reticulum (ER) and lysosome prevented neurodegeneration in a C9orf72 repeat expansion drosophila amyotrophic lateral sclerosis (ALS) model	12
Opportunities and challenges in application of artificial intelligence in pharmacology	12
Blockade of fructose transporter protein GLUT5 inhibits proliferation of colon cancer cells: proof of concept for a new class of anti-tumor therapeutics	12
GSK-3β-mediated regulation of Nrf2/HO-1 signaling as a new therapeutic approach in the treatment of movement disorders	12
The brain consequences of systemic inflammation were not fully alleviated by ibuprofen treatment in mice	11
COVID-19: potential therapeutics for pediatric patients	11
An update on mode of action of metformin in modulation of meta-inflammation and inflammaging	11
Tropisetron attenuates pancreas apoptosis in the STZ-induced diabetic rats: involvement of SIRT1/NF-κB signaling	11
What is autism?	11
Oridonin enhances antitumor effects of doxorubicin in human osteosarcoma cells	11
Xanthotoxin reverses Parkinson’s disease-like symptoms in zebrafish larvae and mice models: a comparative study	11
Cellular, synaptic, and network effects of chemokines in the central nervous system and their implications to behavior	11
The impact of exogenous vitamin D on thyroid autoimmunity in euthyroid men with autoimmune thyroiditis and early-onset androgenic alopecia	11
Sigma receptors and neurological disorders	11
Influence of CYP2C9, VKORC1, and CYP4F2 polymorphisms on the pharmacodynamic parameters of warfarin: a cross-sectional study	10
Antiviral drug research for Japanese encephalitis: an updated review	10
Development and treatment of cognitive inflexibility in sub-chronic stress–re-stress (SRS) model of PTSD	10
Proton pump inhibitor-induced gut dysbiosis and immunomodulation: current knowledge and potential restoration by probiotics	10
Plant-derived immuno-adjuvants in vaccines formulation: a promising avenue for improving vaccines efficacy against SARS-CoV-2 virus	10
Artesunate inhibits melanoma progression in vitro via suppressing STAT3 signaling pathway	10
Influence of G protein-biased agonists of μ-opioid receptor on addiction-related behaviors	10
Contribution of serotonin receptor subtypes to hallucinogenic activity of 25I-NBOMe and to its effect on neurotransmission	10
Novel adenosine derivatives against SARS-CoV-2 RNA-dependent RNA polymerase: an in silico perspective	10
Antidepressant-like effects of cannabidiol in a rat model of early-life stress with or without adolescent cocaine exposure	10
Antiviral peptides against SARS-CoV-2: therapeutic targets, mechanistic antiviral activity, and efficient delivery	10
Effects of chronic fluoxetine treatment on anxiety- and depressive-like behaviors in adolescent rodents – systematic review and meta-analysis	10
RETRACTED ARTICLE: Roflumilast and tadalafil improve learning and memory deficits in intracerebroventricular Aβ1–42 rat model of Alzheimer’s disease through modulations of hippocampal cAMP/cGMP/BDNF s	10
A perspective on the applications of furin inhibitors for the treatment of SARS-CoV-2	9
The association of the quality of sleep with proinflammatory cytokine profile in inflammatory bowel disease patients	9
Cell cycle arrest-mediated cell death by morin in MDA-MB-231 triple-negative breast cancer cells	9
Design and optimization various formulations of PEGylated niosomal nanoparticles loaded with phytochemical agents: potential anti-cancer effects against human lung cancer cells	9
Metamizole relieves pain by influencing cytokine levels in dorsal root ganglia in a rat model of neuropathic pain	9
Effects of the synthetic cannabinoid XLR-11 on the viability and migration rates of human brain microvascular endothelial cells in a clinically-relevant model	9
Sodium–glucose cotransporter inhibitors and kidney fibrosis: review of the current evidence and related mechanisms	8
Pro-inflammatory cytokines, but not brain- and extracellular matrix-derived proteins, are increased in the plasma following electrically induced kindling of seizures	8
Pharmacogenomics of statins: lipid response and other outcomes in Brazilian cohorts	8
Repositioning antispasmodic drug Papaverine for the treatment of chronic myeloid leukemia	8
Chemokine (C–C motif) ligand 5 (RANTES) concentrations in the peripheral blood of patients with a depressive disorder	8
Apoptotic and antioxidant effects in HCT-116 colorectal carcinoma cells by a spiro-acridine compound, AMTAC-06	8
Memantine hydrochloride: a drug to be repurposed against Chikungunya virus?	8
Spinal mechanisms contributing to the development of pain hypersensitivity induced by sphingolipids in the rat	8
Atypical antipsychotic olanzapine inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells	8
The effect of tocilizumab on cytokine release syndrome in COVID-19 patients	8
Estrogen fluctuations during the menopausal transition are a risk factor for depressive disorders	8
Radiosynthesis and evaluation of [18F]FMTP, a COX-2 PET ligand	8
Involvement of the ventral, but not dorsal, hippocampus in anxiety-like behaviors in mice exposed to the elevated plus maze: participation of CRF1 receptor and PKA pathway	8