OOIR: Observatory of International Research

Papers

(The TQCC of Pharmacological Reports is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Acknowledgments	84
The influence of preconditioning with low dose of LPS on paraquat-induced neurotoxicity, microglia activation and expression of α-synuclein and synphilin-1 in the dopaminergic system	66
Safety of non-standard regimen of systemic steroid therapy in patients with Graves’ orbitopathy: a single-centre experience	65
Correction to: The impact of IL-10 and CYP3A5 gene polymorphisms on dose-adjusted trough blood tacrolimus concentrations in early post-renal transplant recipients	64
A derivative of 3-(1,3-diarylallylidene)oxindoles inhibits dextran sulfate sodium-induced colitis in mice	64
Atypical antipsychotic olanzapine inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells	52
The KCNQ channel inhibitor XE991 suppresses nicotinic acetylcholine receptor-mediated responses in rat intracardiac ganglion neurons	45
FNF-12, a novel benzylidene-chromanone derivative, attenuates inflammatory response in in vitro and in vivo asthma models mediated by M2-related Th2 cytokines via MAPK and NF-kB signaling	44
The effect of poly I:C or LPS priming on the therapeutic efficacy of mesenchymal stem cells in an adjuvant-induced arthritis rat model	43
Chlorogenic acid reduces inflammation in murine model of acute pancreatitis	42
Hypoxia-inducible factors and essential hypertension: narrative review of experimental and clinical data	42
Potential drugs for the treatment of Alzheimer’s disease	40
Luteolin for neurodegenerative diseases: a review	37
Note from editors	36
Genetic liability for anxiety and treatment response to the monoamine stabilizer OSU6162 in alcohol dependence: a retrospective secondary analysis	35
Correction to: The role of childhood adversities, FKBP5, BDNF, NRN1, and generalized self-efficacy in suicide attempts in alcohol-dependent patients	34
The study of platelet aggregation using a microtiter plate reader ‒ methodological considerations	33
Novel method of measurement of in vitro drug uptake in OATP1B3 overexpressing cells in the presence of dextran	33
β-Carboline derivatives are potent against Acute Myeloid Leukemia in vitro and in vivo	29
Padsevonil suppresses seizures without inducing cell death in neonatal rats	28
Real-world experience with direct-acting antiviral therapy in HCV-infected patients with cirrhosis and esophageal varices	28
Genotyping NUDT15*3 rs1166855232 reveals higher frequency of potential adverse effects of thiopurines in Natives and Mestizos from Mexico	28
Evaluation of nano-curcumin against inhaled paraquat-induced lung injury in rats	27
The ixabepilone and vandetanib combination shows synergistic activity in docetaxel-resistant MDA-MB-231 breast cancer cells	25
Effect of vitamin D supplementation on OPG/RANKL signalling activities in endothelial tissue damage in diet-induced diabetic rat model	25

Assessing the effects of 5-HT2A and 5-HT5A receptor antagonists on DOI-induced head-twitch response in male rats using marker-less deep learning algorithms	25
Association analysis of ADRB3:rs4994 with urodynamic outcome, six months after a single intra-detrusor injection of botulinum toxin, in women with overactive bladder	24
Preclinical efficacy of cannabidiol for the treatment of early-life seizures	23
The impact of noradrenergic neurotoxin DSP-4 and noradrenaline transporter knockout (NET-KO) on the activity of liver cytochrome P450 3A (CYP3A) in male and female mice	23
The possible pathogenesis of liver fibrosis: therapeutic potential of natural polyphenols	23
Carvacrol in asthma management: a comprehensive review of its therapeutic potential and mechanisms of action	23
Pten knockout affects drug resistance differently in melanoma and kidney cancer	22
The potential action of SSRIs in the treatment of skin diseases including atopic dermatitis and slow-healing wounds	21
Vortioxetine liposomes as a novel alternative to improve drug stability under stress conditions: toxicity studies and evaluation of antidepressant-like effect	20
A review of serious adverse events linked with GLP-1 agonists in type 2 diabetes mellitus and obesity treatment	20
Dietary phytochemicals/nutrients as promising protector of breast cancer development: a comprehensive analysis	20
Olanzapine alters the expression of gasotransmitter-related enzymes: CBS and HO-2 in the rat hippocampus and striatum	20
Evaluation of the 5-HT2C receptor drugs RO 60-0175, WAY 161503 and mirtazepine in a preclinical model of comorbidity of depression and cocaine addiction	18
COVID-19: potential therapeutics for pediatric patients	18
The association of the quality of sleep with proinflammatory cytokine profile in inflammatory bowel disease patients	18
Liquid chromatography–tandem mass spectrometry method for mycophenolic acid and its glucuronide determination in saliva samples from children with nephrotic syndrome	17
Comprehensive evaluation of ibuprofenate amino acid isopropyl esters: insights into antioxidant activity, cytocompatibility, and cyclooxygenase inhibitory potential	17
The therapeutic potential of vitamin D supplementation in asthma	17
Agonistic properties of a series of psychotropic drugs at 5-HT1A receptors in rat and human brain membranes determined by [35S]GTPγS binding assay	16
Maternal feeding patterns affect the offspring’s brain: focus on serotonin 5-HT2C and 5-HT2A receptors	16
The impact of exogenous vitamin D on thyroid autoimmunity in euthyroid men with autoimmune thyroiditis and early-onset androgenic alopecia	16
Comparative study of the binding between chlorogenic acid and four proteins by isothermal titration calorimetry, spectroscopy and docking methods	16
Chronic restraint stress induces changes in the cerebral Galpha 12/13 and Rho-GTPase signaling network	15
JR-AB2-011 induces fast metabolic changes independent of mTOR complex 2 inhibition in human leukemia cells	15
Activation of 5-HT7 receptors in the mouse dentate gyrus does not affect theta-burst-induced plasticity at the perforant path synapse	15
Antidepressant-like effects of cannabidiol in a rat model of early-life stress with or without adolescent cocaine exposure	15
Antiviral drug research for Japanese encephalitis: an updated review	14
Red cell microparticles produced using high-pressure extrusion enhance both primary and secondary hemostasis	14
Group III metabotropic glutamate receptors: guardians against excitotoxicity in ischemic brain injury, with implications for neonatal contexts	14
Essential phospholipids impact cytokine secretion and alter lipid-metabolizing enzymes in human hepatocyte cell lines	14
An association of ABCG8: rs11887534 polymorphism and HDL-cholesterol response to statin treatment in the Polish population	13
Interaction of hallucinogenic rapid-acting antidepressants with mGlu2/3 receptor ligands as a window for more effective therapies	13
KM-408, a novel phenoxyalkyl derivative as a potential anticonvulsant and analgesic compound for the treatment of neuropathic pain	13
Correction: Access to high-fat diet results in increased sensitivity to the psychostimulant effects of MDPV in mice	13
The effect of new atypical antipsychotic drugs on the expression of transcription factors regulating cytochrome P450 enzymes in rat liver	13
The roles of cellular protease interactions in viral infections and programmed cell death: a lesson learned from the SARS-CoV-2 outbreak and COVID-19 pandemic	13
The effects of the recurrent social isolation stress on fear extinction and dopamine D2 receptors in the amygdala and the hippocampus	12
Retraction Note to: Anti-inflammatory role of leptin in glial cells through p38 MAPK pathway inhibition	12
Melatonin increases collagen content accumulation and Fibroblast Growth Factor-2 secretion in cultured human cardiac fibroblasts	12
MDPV (3,4-methylenedioxypyrovalerone) administered to mice during development of the central nervous system produces persistent learning and memory impairments	12
The emerging role of mechanical and topographical factors in the development and treatment of nervous system disorders: dark and light sides of the force	12
A review of the mechanisms underlying selected comorbidities in Alzheimer’s disease	12
Role of the β2-adrenergic receptor in podocyte injury and recovery	11
Interactions of antidepressants with concomitant medications—safety of complex therapies in multimorbidities	11
Nanoparticles coated by chloramphenicol in hydrogels as a useful tool to increase the antibiotic release and antibacterial activity in dermal drug delivery	10
Colonic inflammation induces changes in glucose levels through modulation of incretin system	10
Redox homeostasis in human renal cells that had been treated with amphotericin B in combination with selected 1,3,4-thiadiazole derivatives	10
Advances in the anti-tumor mechanisms of saikosaponin D	10
A re-consideration of neural/receptor mechanisms in chemotherapy-induced nausea and vomiting: current scenario and future perspective	10
Synthetic free fatty acid receptor (FFAR) 2 agonist 4-CMTB and FFAR4 agonist GSK13764 inhibit colon cancer cell growth and migration and regulate FFARs expression in in vitro and in vivo models of col	10

Correction to: The oxidation and hypoglycaemic effect of sorafenib in streptozotocin-induced diabetic rats	10
Extracellular acidification reveals the antiarrhythmic properties of amiodarone related to late sodium current-induced atrial arrhythmia	9
Correction: Compound PZ-1262, a 4-isoquinoline-sulfonamide analog of Brexpiprazole, produces potential antidepressant, anxiolytic and procognitive effects in rodent models	9
Cannabinoids in the treatment of glioblastoma	9
Metabotropic glutamate receptors—guardians and gatekeepers in neonatal hypoxic-ischemic brain injury	9
Access to high-fat diet results in increased sensitivity to the psychostimulant effects of MDPV in mice	9
Identification of mitogen-activated protein kinase phosphatase-1 (MKP-1) protein partners using tandem affinity purification and mass spectrometry	9
Critical interactions between opioid and cannabinoid receptors during tolerance and physical dependence development to opioids in the murine gastrointestinal tract: proof of concept	9
Plant-derived immuno-adjuvants in vaccines formulation: a promising avenue for improving vaccines efficacy against SARS-CoV-2 virus	9
The impact of IL-10 and CYP3A5 gene polymorphisms on dose-adjusted trough blood tacrolimus concentrations in early post-renal transplant recipients	9
Lymphopenia associated with sphingosine 1-phosphate receptor modulators (S1PRMs) in multiple sclerosis: analysis of European pharmacovigilance data	8
Acetaminophen treatment evokes anticontractile effects in rat aorta by blocking L-type calcium channels	8
The effect of valproate on the amino acids, monoamines, and kynurenic acid concentrations in brain structures involved in epileptogenesis in the pentylenetetrazol-kindled rats	8
Mitochondrial targeted antioxidants as potential therapy for huntington’s disease	8
High-performance liquid chromatography with fluorescence detection for mycophenolic acid determination in saliva samples	8
Sigma receptors and neurological disorders	8
Multiple sclerosis: a narrative overview of current pharmacotherapies and emerging treatment prospects	8
Regulatory effects of resveratrol on nitric oxide signaling in cardiovascular diseases	8
Radiosensitizing effect of dendrosomal nanoformulation of curcumin on cancer cells	8
Oridonin enhances antitumor effects of doxorubicin in human osteosarcoma cells	8
Recent review of COVID-19 management: diagnosis, treatment and vaccination	8
Gαi-derived peptide binds the µ-opioid receptor	8
Transcriptome analysis of an AKT inhibitor-resistant endometrial cancer cell line	8
Investigating whether alcohol is transformed to norepinephrine or dopamine in the mouse brain	8
Insulin in combination with pioglitazone prevents advanced cachexia in 256-Walker tumor-bearing rats: effect is greater than treatment alone and is associated with improved insulin sensitivity	8
Hepatic drug-metabolizing enzymes and drug transporters in Wilson’s disease patients with liver failure	7
Acyclic sesquiterpenes nerolidol and farnesol: mechanistic insights into their neuroprotective potential	7
Effects of N-acetylcysteine and acetyl-l-carnitine on acute PTZ-induced seizures in larval and adult zebrafish	7
Psilocybin and the glutamatergic pathway: implications for the treatment of neuropsychiatric diseases	7
Correction to: Radiosensitizing effect of dendrosomal nanoformulation of curcumin on cancer cells	7
The impact of rosuvastatin on hypothalamic–pituitary–testicular axis activity in metformin-treated and metformin-naïve men with low testosterone levels: a pilot study	7
Efficacy of COVID-19 vaccines: a systematic review and network meta-analysis of phase 3 randomized controlled trials	7
Identification of genes regulated by trait sensitivity to negative feedback and prolonged alcohol consumption in rats	7
Suppression of nitric oxide synthase aggravates non-alcoholic steatohepatitis and atherosclerosis in SHRSP5/Dmcr rat via acceleration of abnormal lipid metabolism	7
New gold(III) complexes TGS 121, 404, and 702 show anti-tumor activity in colitis-induced colorectal cancer: an in vitro and in vivo study	7
Association between gene polymorphisms and initial warfarin therapy in patients after heart valve surgery	7
Inhibitory effect of atomoxetine on Nav1.2 voltage-gated sodium channel currents	7
DPP-4 inhibitors and type 2 diabetes mellitus in Parkinson’s disease: a mutual relationship	7
Saliva as a matrix for therapeutic drug monitoring and disease biomarkers in children and adolescents	7
Combined effects of HCRTR1/2 gene variants and non-genetic factors on sleep-wake transition and hemodynamic stability during propofol, dexmedetomidine, and remifentanil anesthesia	7
Impact of levetiracetam and ethanol on memory, selected neurotransmitter levels, oxidative stress parameters, and essential elements in rats	7
JG26 attenuates ADAM17 metalloproteinase-mediated ACE2 receptor processing and SARS-CoV-2 infection in vitro	7
Anti-nociceptive potential of an isatin-derived dual fatty acid amide hydrolase-monoacylglycerol lipase inhibitor	7