OOIR: Observatory of International Research

Papers

(The TQCC of Pharmacological Reports is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
The KCNQ channel inhibitor XE991 suppresses nicotinic acetylcholine receptor-mediated responses in rat intracardiac ganglion neurons	97
Safety of non-standard regimen of systemic steroid therapy in patients with Graves’ orbitopathy: a single-centre experience	88
Hypoxia-inducible factors and essential hypertension: narrative review of experimental and clinical data	72
Acknowledgments	70
Potential drugs for the treatment of Alzheimer’s disease	63
Iodothyronine deiodinases in patients with stable chronic obstructive pulmonary disease - preliminary results	58
A derivative of 3-(1,3-diarylallylidene)oxindoles inhibits dextran sulfate sodium-induced colitis in mice	58
The effect of poly I:C or LPS priming on the therapeutic efficacy of mesenchymal stem cells in an adjuvant-induced arthritis rat model	57
Luteolin for neurodegenerative diseases: a review	54
Note from editors	54
Novel method of measurement of in vitro drug uptake in OATP1B3 overexpressing cells in the presence of dextran	52
Genetic liability for anxiety and treatment response to the monoamine stabilizer OSU6162 in alcohol dependence: a retrospective secondary analysis	51
Real-world experience with direct-acting antiviral therapy in HCV-infected patients with cirrhosis and esophageal varices	51
Assessing the effects of 5-HT2A and 5-HT5A receptor antagonists on DOI-induced head-twitch response in male rats using marker-less deep learning algorithms	49
Padsevonil suppresses seizures without inducing cell death in neonatal rats	46
The HPA axis and kynurenine pathway: exploring the role of stress and neuroinflammation in treatment-resistant depression	44
Evaluation of nano-curcumin against inhaled paraquat-induced lung injury in rats	40
β-Carboline derivatives are potent against Acute Myeloid Leukemia in vitro and in vivo	37
The study of platelet aggregation using a microtiter plate reader ‒ methodological considerations	35
Association analysis of ADRB3:rs4994 with urodynamic outcome, six months after a single intra-detrusor injection of botulinum toxin, in women with overactive bladder	34
The impact of noradrenergic neurotoxin DSP-4 and noradrenaline transporter knockout (NET-KO) on the activity of liver cytochrome P450 3A (CYP3A) in male and female mice	32
Genetic variants in GRIN2B and NTRK2 on the etiology and treatment response to valproate and lithium in patients with bipolar disorder	31
Glutathione deficiency in the early postnatal developmental period as a neurodevelopmental animal model of schizophrenia	30
Novel receptor tyrosine kinase-targeted strategies to overcome resistance in oral squamous cell carcinoma	28
Preclinical efficacy of cannabidiol for the treatment of early-life seizures	28

Dietary phytochemicals/nutrients as promising protector of breast cancer development: a comprehensive analysis	27
The possible pathogenesis of liver fibrosis: therapeutic potential of natural polyphenols	27
The ketogenic diet in Parkinson’s disease: a potential therapeutic strategy	27
The potential action of SSRIs in the treatment of skin diseases including atopic dermatitis and slow-healing wounds	27
Prospects and challenges in intracellular delivery of therapeutic proteins	25
Pten knockout affects drug resistance differently in melanoma and kidney cancer	25
The ixabepilone and vandetanib combination shows synergistic activity in docetaxel-resistant MDA-MB-231 breast cancer cells	25
Carvacrol in asthma management: a comprehensive review of its therapeutic potential and mechanisms of action	25
A review of serious adverse events linked with GLP-1 agonists in type 2 diabetes mellitus and obesity treatment	24
Early plasma changes of HIF-1 alpha, matrix metalloproteinases-2 and − 9, and tissue inhibitor of matrix metalloproteinase-1 in patients with infantile hemangiomas treated with propranolol	23
Olanzapine alters the expression of gasotransmitter-related enzymes: CBS and HO-2 in the rat hippocampus and striatum	22
Palbociclib in endocrine-resistant metastatic breast cancer patients: gene polymorphism- based study	21
The role of microbiota modulation in preventing Alzheimer’s disease- a review	21
The effect of salidroside, an active component of Rhodiola rosea, on the metabolic activity of rat and human cytochromes P450 in preclinical studies	20
Vortioxetine liposomes as a novel alternative to improve drug stability under stress conditions: toxicity studies and evaluation of antidepressant-like effect	20
The therapeutic potential of vitamin D supplementation in asthma	19
Evaluation of the 5-HT2C receptor drugs RO 60-0175, WAY 161503 and mirtazepine in a preclinical model of comorbidity of depression and cocaine addiction	19
Comprehensive evaluation of ibuprofenate amino acid isopropyl esters: insights into antioxidant activity, cytocompatibility, and cyclooxygenase inhibitory potential	19
Activation of 5-HT7 receptors in the mouse dentate gyrus does not affect theta-burst-induced plasticity at the perforant path synapse	18
Liquid chromatography–tandem mass spectrometry method for mycophenolic acid and its glucuronide determination in saliva samples from children with nephrotic syndrome	18
Red cell microparticles produced using high-pressure extrusion enhance both primary and secondary hemostasis	18
JR-AB2-011 induces fast metabolic changes independent of mTOR complex 2 inhibition in human leukemia cells	18
Naringenin and quercetin alter mouse rod phototransduction kinetics in a manner consistent with phosphodiesterase-6 inhibition	17
The roles of cellular protease interactions in viral infections and programmed cell death: a lesson learned from the SARS-CoV-2 outbreak and COVID-19 pandemic	17
Agonistic properties of a series of psychotropic drugs at 5-HT1A receptors in rat and human brain membranes determined by [35S]GTPγS binding assay	17
MIM1 – a selective Mcl-1 protein inhibitor augments the proapoptotic activity of moxifloxacin toward MDA-MB-231 triple-negative breast cancer cells – a preliminary in vitro study	17
Synthesis and evaluation of KR-12, an LL-37 fragment, and its short-chain fatty acid derivatives: selective cytotoxicity in colorectal cancer cells and anti-tumor efficacy in an azoxymethane/DSS-induc	16
Group III metabotropic glutamate receptors: guardians against excitotoxicity in ischemic brain injury, with implications for neonatal contexts	15
Dysregulation of store-operated calcium entry in fibroblast lines from adult and juvenile-onset Huntington’s disease patients	15
A novel 2-oxopyrrolidine derivative (LN-53) efficiently induces Nrf-2 signaling pathway activation in human epidermal keratinocytes	15
Involvement of uridine in brain and gut health: insights into its neuroprotective potential via the gut-brain axis	15
Essential phospholipids impact cytokine secretion and alter lipid-metabolizing enzymes in human hepatocyte cell lines	15
The effects of the recurrent social isolation stress on fear extinction and dopamine D2 receptors in the amygdala and the hippocampus	14
Melatonin increases collagen content accumulation and Fibroblast Growth Factor-2 secretion in cultured human cardiac fibroblasts	14
Peptide-based strategies for overcoming taxol-resistance in cancer therapy – a narrative review	14
Interaction of hallucinogenic rapid-acting antidepressants with mGlu2/3 receptor ligands as a window for more effective therapies	13
Correction: Access to high-fat diet results in increased sensitivity to the psychostimulant effects of MDPV in mice	13
KM-408, a novel phenoxyalkyl derivative as a potential anticonvulsant and analgesic compound for the treatment of neuropathic pain	13
Retraction Note to: Anti-inflammatory role of leptin in glial cells through p38 MAPK pathway inhibition	13
The effect of new atypical antipsychotic drugs on the expression of transcription factors regulating cytochrome P450 enzymes in rat liver	12
A re-consideration of neural/receptor mechanisms in chemotherapy-induced nausea and vomiting: current scenario and future perspective	12
Interactions of antidepressants with concomitant medications—safety of complex therapies in multimorbidities	12
The cortisol axis and psychiatric disorders: an updated review	11
Synthetic free fatty acid receptor (FFAR) 2 agonist 4-CMTB and FFAR4 agonist GSK13764 inhibit colon cancer cell growth and migration and regulate FFARs expression in in vitro and in vivo models of col	11
Cannabinoids in the treatment of glioblastoma	11
Redox homeostasis in human renal cells that had been treated with amphotericin B in combination with selected 1,3,4-thiadiazole derivatives	11
Nanoparticles coated by chloramphenicol in hydrogels as a useful tool to increase the antibiotic release and antibacterial activity in dermal drug delivery	11
MDPV (3,4-methylenedioxypyrovalerone) administered to mice during development of the central nervous system produces persistent learning and memory impairments	11
Plant-derived immuno-adjuvants in vaccines formulation: a promising avenue for improving vaccines efficacy against SARS-CoV-2 virus	11
Advances in the anti-tumor mechanisms of saikosaponin D	11

Correction: Compound PZ-1262, a 4-isoquinoline-sulfonamide analog of Brexpiprazole, produces potential antidepressant, anxiolytic and procognitive effects in rodent models	11
The Sigma1 receptor antagonist CM304 potentiates the antinociceptive effects of the cannabinoid receptor agonist delta9-tetrahydrocannabinol in rats and mice	11
Correction: Marizomib in the therapy of brain tumors—how far did we go and where do we stand?	10
Metabotropic glutamate receptors—guardians and gatekeepers in neonatal hypoxic-ischemic brain injury	10
High-performance liquid chromatography with fluorescence detection for mycophenolic acid determination in saliva samples	10
Insulin in combination with pioglitazone prevents advanced cachexia in 256-Walker tumor-bearing rats: effect is greater than treatment alone and is associated with improved insulin sensitivity	10
Role of the β2-adrenergic receptor in podocyte injury and recovery	10
Extracellular acidification reveals the antiarrhythmic properties of amiodarone related to late sodium current-induced atrial arrhythmia	10
Lymphopenia associated with sphingosine 1-phosphate receptor modulators (S1PRMs) in multiple sclerosis: analysis of European pharmacovigilance data	10
Transcriptome analysis of an AKT inhibitor-resistant endometrial cancer cell line	10
Radiosensitizing effect of dendrosomal nanoformulation of curcumin on cancer cells	10
Multiple sclerosis: a narrative overview of current pharmacotherapies and emerging treatment prospects	10
Identification of mitogen-activated protein kinase phosphatase-1 (MKP-1) protein partners using tandem affinity purification and mass spectrometry	10
Recent review of COVID-19 management: diagnosis, treatment and vaccination	10
Thiazolidine derivative (LPSF/CR-35) modulates the production of IL-17A, IL-10, IL-4, TFN, CCL2 and CXCL8 in PBMC from systemic sclerosis patients	10
Efficacy of COVID-19 vaccines: a systematic review and network meta-analysis of phase 3 randomized controlled trials	10
Access to high-fat diet results in increased sensitivity to the psychostimulant effects of MDPV in mice	10
The effect of valproate on the amino acids, monoamines, and kynurenic acid concentrations in brain structures involved in epileptogenesis in the pentylenetetrazol-kindled rats	9
Identification of genes regulated by trait sensitivity to negative feedback and prolonged alcohol consumption in rats	9
Mitochondrial targeted antioxidants as potential therapy for huntington’s disease	9
Solcumin™: a functional hybrid particle with potent anti-inflammatory and antioxidant activities and enhanced storage stability	9
Combined effects of HCRTR1/2 gene variants and non-genetic factors on sleep-wake transition and hemodynamic stability during propofol, dexmedetomidine, and remifentanil anesthesia	9
The impact of gadolinium doping on physicochemical properties and neuroprotective activity of polyacrylic acid conjugated cerium oxide nanoparticles – in vitro study of potential theranostics for neur	9
Gαi-derived peptide binds the µ-opioid receptor	9
Regulatory effects of resveratrol on nitric oxide signaling in cardiovascular diseases	9
The impact of muscarinic and mGlu receptors modulators on MK-801-induced impairments in NO-dependent processes both in vitro and in vivo	9
Effects of N-acetylcysteine and acetyl-l-carnitine on acute PTZ-induced seizures in larval and adult zebrafish	9
Investigating whether alcohol is transformed to norepinephrine or dopamine in the mouse brain	9
DPP-4 inhibitors and type 2 diabetes mellitus in Parkinson’s disease: a mutual relationship	9
Cobalt protoporphyrin IX induces transient, dose- and time-dependent granulocyte mobilization with mild metabolic effects in mice	9
Anti-nociceptive potential of an isatin-derived dual fatty acid amide hydrolase-monoacylglycerol lipase inhibitor	9
Acyclic sesquiterpenes nerolidol and farnesol: mechanistic insights into their neuroprotective potential	9
Inhibitory effect of atomoxetine on Nav1.2 voltage-gated sodium channel currents	9
Saliva as a matrix for therapeutic drug monitoring and disease biomarkers in children and adolescents	8
Effects of magnolol on the liver antioxidant status in rats with diabetes	8
Correction to: Selective cytotoxic and genotoxic activities of 5-(2-bromo-5- methoxybenzylidene)-thiazolidine-2,4-dione against NCI-H292 human lung carcinoma cells	8
JG26 attenuates ADAM17 metalloproteinase-mediated ACE2 receptor processing and SARS-CoV-2 infection in vitro	8
Interactions of fentanyl with blood platelets and plasma proteins: platelet sensitivity to prasugrel metabolite is not affected by fentanyl under in vitro conditions	8
Psilocybin and the glutamatergic pathway: implications for the treatment of neuropsychiatric diseases	8
Atorvastatin attenuates the expression of damage-associated molecular patterns and inflammatory cytokines in patients with psoriasis	8
Correction to: Radiosensitizing effect of dendrosomal nanoformulation of curcumin on cancer cells	8
Effect of 28 days treatment of baricitinib on mechanical allodynia, osteopenia, and loss of nerve fibers in an experimental model of type-1 diabetes mellitus	8
Suppression of nitric oxide synthase aggravates non-alcoholic steatohepatitis and atherosclerosis in SHRSP5/Dmcr rat via acceleration of abnormal lipid metabolism	8
Cannabidiol may prevent the development of congestive hepatopathy secondary to right ventricular hypertrophy associated with pulmonary hypertension in rats	8
Ethanol deprivation and central 5-HT deficiency differentially affect the mRNA editing of the 5-HT2C receptor in the mouse brain	8
Protective effect of hygrolansamycin C against corticosterone-induced toxicity and oxidative stress-mediated via autophagy and the MAPK signaling pathway	8
Impact of levetiracetam and ethanol on memory, selected neurotransmitter levels, oxidative stress parameters, and essential elements in rats	8
The application of telmisartan in central nervous system disorders	7
Association between gene polymorphisms and initial warfarin therapy in patients after heart valve surgery	7
Preclinical models of treatment-resistant depression: challenges and perspectives	7
Cardiovascular safety of psychedelic medicine: current status and future directions	7
Network analysis of monoamines involved in anxiety-like behavior in a rat model of osteoarthritis	7
Anthracyclines as diagnostic stressors: mitophagy signaling and hidden cardiac vulnerability	7
CYP2C19 gene polymorphism in Ningxia	7
Exploring the anti-inflammatory activity of sulforaphane metabolites	7
Upadacitinib as rescue therapy for acute severe ulcerative colitis and severe Crohn’s disease – current knowledge and future directions	7
Molecular mechanisms and therapeutic strategies of GPX4 regulation in acute kidney injury	7
Residence time in drug discovery: current insights and future perspectives	7
The sertraline metabolite, desmethylsertraline, may be implicated in adverse outcomes reported after gestational sertraline use: insights from a study in zebrafish	7
Molecular pattern of a decrease in the rewarding effect of cocaine after an escalating-dose drug regimen	7
Achieving target plasma concentrations of beta-lactam antibiotics in critically ill patients: a retrospective study of full-dose administration in the first 24 hours	7
New gold(III) complexes TGS 121, 404, and 702 show anti-tumor activity in colitis-induced colorectal cancer: an in vitro and in vivo study	7
A single dose of haloperidol decanoate induces short-term hippocampal neuroinflammation: focus on the glial response	7
The effect of chronic exposure to metformin in a new type-2 diabetic NONcNZO10/LtJ mouse model of stroke	7
Integrated computational and experimental approach to identify Nrf2-regulated molecular targets in cerebral ischemia	7
GET73 modulates lipopolysaccharide- and ethanol-induced increase in cytokine/chemokine levels in primary cultures of microglia of rat cerebral cortex	7