OOIR: Observatory of International Research

Papers

(The TQCC of Pharmacological Reports is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
ONC206, an imipridone derivative, demonstrates anti-colorectal cancer activity against stem/progenitor cells in 3D cell cultures and in patient-derived organoids	78
Therapeutic implications of phosphorylation- and dephosphorylation-dependent factors of cAMP-response element-binding protein (CREB) in neurodegeneration	61
Reno-protective effect of protocatechuic acid is independent of sex-related differences in murine model of UUO-induced kidney injury	60
Cannabinoids in the treatment of glioblastoma	57
The impact of excessive maternal weight on the risk of neuropsychiatric disorders in offspring—a narrative review of clinical studies	54
Redox homeostasis in human renal cells that had been treated with amphotericin B in combination with selected 1,3,4-thiadiazole derivatives	52
A derivative of 3-(1,3-diarylallylidene)oxindoles inhibits dextran sulfate sodium-induced colitis in mice	45
Advances in the anti-tumor mechanisms of saikosaponin D	42
Presynaptic antiseizure medications - basic mechanisms and clues for their rational combinations	41
GET73 modulates lipopolysaccharide- and ethanol-induced increase in cytokine/chemokine levels in primary cultures of microglia of rat cerebral cortex	41
In vitro biological evaluation of a novel folic acid-targeted receptor quantum dot−β−cyclodextrin carrier for C−2028 unsymmetrical bisacridine in the treatment of human lung and prostate cancers	41
Synthetic free fatty acid receptor (FFAR) 2 agonist 4-CMTB and FFAR4 agonist GSK13764 inhibit colon cancer cell growth and migration and regulate FFARs expression in in vitro and in vivo models of col	40
Synergistic effect of antibiotics, α-linolenic acid and solvent type against Staphylococcus aureus biofilm formation	39
Advanced pharmacological and pharmacokinetic evaluation of 1,3 dimethylpurine-2,6-dione derivative (GR-14) with prominent mood-modulating activity in rats	38
Effects of puerarin on gait disturbance in a 6-hydroxydopamine mouse model of Parkinson’s disease	36
Targeting glucocorticoid receptor signaling pathway for treatment of stress-related brain disorders	34
Shedding light on the role of CX3CR1 in the pathogenesis of schizophrenia	34
Use of glucocorticoids and azithromycin in the therapy of COVID-19	34
Atypical antipsychotic olanzapine inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells	33
Chlorogenic acid reduces inflammation in murine model of acute pancreatitis	32
Colonic inflammation induces changes in glucose levels through modulation of incretin system	31
The influence of preconditioning with low dose of LPS on paraquat-induced neurotoxicity, microglia activation and expression of α-synuclein and synphilin-1 in the dopaminergic system	29
Allosteric modulation of dopamine D2L receptor in complex with Gi1 and Gi2 proteins: the effect of subtle structural and stereochemical ligand modifications	27
Correction to: The impact of IL-10 and CYP3A5 gene polymorphisms on dose-adjusted trough blood tacrolimus concentrations in early post-renal transplant recipients	26
FNF-12, a novel benzylidene-chromanone derivative, attenuates inflammatory response in in vitro and in vivo asthma models mediated by M2-related Th2 cytokines via MAPK and NF-kB signaling	25

Synthetic lipoproteins based on apolipoprotein E coupled to fullerenol have anti-atherosclerotic properties	25
Antiproliferative pharmacophore azo-hydrazone analogue BT-1F exerts death signalling pathway targeting STAT3 in solid tumour	25
The effect of poly I:C or LPS priming on the therapeutic efficacy of mesenchymal stem cells in an adjuvant-induced arthritis rat model	24
Plant-derived immuno-adjuvants in vaccines formulation: a promising avenue for improving vaccines efficacy against SARS-CoV-2 virus	23
Exposure to chronic stressor upsurges the excitability of serotoninergic neurons and diminishes concentrations of circulating corticosteroids in rats two weeks thereafter	23
Correction: Real-world experience with molnupiravir during the period of SARS-CoV-2 Omicron variant dominance	23
The KCNQ channel inhibitor XE991 suppresses nicotinic acetylcholine receptor-mediated responses in rat intracardiac ganglion neurons	23
Potential drugs for the treatment of Alzheimer’s disease	22
Chloroquine prevents hypoxic accumulation of HIF-1α by inhibiting ATR kinase: implication in chloroquine-mediated chemosensitization of colon carcinoma cells under hypoxia	22
CYX-5, a G-protein biassed MOP receptor agonist, DOP receptor antagonist and KOP receptor agonist, evokes constipation but not respiratory depression relative to morphine in rats	21
Molecular pattern of a decrease in the rewarding effect of cocaine after an escalating-dose drug regimen	21
Antiviral activity of some benzo[g]quinazolines against coxsackievirus B4: biological screening and docking study	20
A re-consideration of neural/receptor mechanisms in chemotherapy-induced nausea and vomiting: current scenario and future perspective	20
Amphetamine-induced prolonged disturbances in tissue levels of dopamine and serotonin in the rat brain	20
GLUT inhibitor WZB117 induces cytotoxicity with increased production of amyloid-beta peptide in SH-SY5Y cells preventable by beta-hydroxybutyrate: implications in Alzheimer’s disease	20
Is metformin neuroprotective against diabetes mellitus-induced neurodegeneration? An updated graphical review of molecular basis	19
Hypoxia-inducible factors and essential hypertension: narrative review of experimental and clinical data	19
Mitragynine inhibits hippocampus neuroplasticity and its molecular mechanism	18
Nanoparticles coated by chloramphenicol in hydrogels as a useful tool to increase the antibiotic release and antibacterial activity in dermal drug delivery	18
Tanshinone IIA targeting cell signaling pathways: a plausible paradigm for cancer therapy	18
Effect of heme oxygenase-1 on the differentiation of human myoblasts and the regeneration of murine skeletal muscles after acute and chronic injury	18
Guanfacine inhibits interictal epileptiform events and sodium currents in prefrontal cortex pyramidal neurons	18
Mediator kinase module proteins, genetic alterations and expression of super-enhancer regulated genes in colorectal cancer	17
Role of the β2-adrenergic receptor in podocyte injury and recovery	16
Transient plasticity response is regulated by histone deacetylase inhibitor in oxygen–glucose deprivation condition	16
MDPV (3,4-methylenedioxypyrovalerone) administered to mice during development of the central nervous system produces persistent learning and memory impairments	16
Safety of non-standard regimen of systemic steroid therapy in patients with Graves’ orbitopathy: a single-centre experience	16
Cytotoxic pathways activated by multifunctional thiosemicarbazones targeting sigma-2 receptors in breast and lung carcinoma cells	16
Unraveling the mechanistic interplay of mediators orchestrating the neuroprotective potential of harmine	16
Interactions of antidepressants with concomitant medications—safety of complex therapies in multimorbidities	15
Targeting GABA signaling in type 1 diabetes and its complications- an update on the state of the art	14
Acknowledgments	14
Formyl peptide receptor 2: a potential therapeutic target for inflammation-related diseases	14
Evaluation of a warfarin dosing algorithm including CYP2C9, VKORC1, and CYP4F2 polymorphisms and non-genetic determinants for the Iranian population	14
The protective effects of statins in traumatic brain injury	13
Blockade of fructose transporter protein GLUT5 inhibits proliferation of colon cancer cells: proof of concept for a new class of anti-tumor therapeutics	13
Simultaneous determination of four antibiotics in human urine and hair samples employing a simple and efficient dispersive micro solid-phase extraction-high performance liquid chromatography	13
Challenges of current treatment and exploring the future prospects of nanoformulations for treatment of atopic dermatitis	13
LY354740, an agonist of glutamatergic metabotropic receptor mGlu2/3 increases the cytochrome P450 2D (CYP2D) activity in the frontal cortical area of rat brain	12
Can probiotics be used in the prevention and treatment of bronchial asthma?	12
Therapeutic drug monitoring of mycophenolic acid (MPA) using volumetric absorptive microsampling (VAMS) in pediatric renal transplant recipients: ultra-high-performance liquid chromatography-tandem ma	12
In vitro antiviral activity of piperidine alkaloids from Senna spectabilis flowers on Chikungunya virus infection	12
Production and therapeutic use of astaxanthin in the nanotechnology era	12
Correction to: The coming together of allosteric and phosphorylation mechanisms in the molecular integration of A2A heteroreceptor complexes in the dorsal and ventral striatal-pallidal GABA neurons	12
Migraine and the microbiota. Can probiotics be beneficial in its prevention? - a narrative review	12
Correction to: The oxidation and hypoglycaemic effect of sorafenib in streptozotocin-induced diabetic rats	12
Oral antiviral treatments for COVID-19: opportunities and challenges	12
Impact of SARS CoV-2 /COVID-19 infection on the course of advanced chronic liver disease and hepatocellular carcinoma	12
Luteolin for neurodegenerative diseases: a review	12
Genetic liability for anxiety and treatment response to the monoamine stabilizer OSU6162 in alcohol dependence: a retrospective secondary analysis	11

Off-label use of anlotinib in malignancies’ treatment: efficacy and management of adverse reactions	11
Alpha-lipoic acid, apocynin or probiotics influence glutathione status and selected inflammatory parameters in C57/BL6 mice when combined with a low-fat diet	11
Compound PZ-1262, a 4-isoquinoline-sulfonamide analog of Brexpiprazole, produces potential antidepressant, anxiolytic and procognitive effects in rodent models	11
Research progress of propofol in alleviating cerebral ischemia/reperfusion injury	11
Nanoformulation of dasatinib cannot overcome therapy resistance of pancreatic cancer cells with low LYN kinase expression	11
Access to high-fat diet results in increased sensitivity to the psychostimulant effects of MDPV in mice	11
Network analysis of monoamines involved in anxiety-like behavior in a rat model of osteoarthritis	11
Secondary fungal infections in SARS-CoV-2 patients: pathological whereabouts, cautionary measures, and steadfast treatments	10
Correction to: The impact of atorvastatin on cardiometabolic risk factors in brothers of women with polycystic ovary syndrome	10
Modulation of allergic contact dermatitis via gut microbiota modified by diet, vitamins, probiotics, prebiotics, and antibiotics	10
Design and optimization various formulations of PEGylated niosomal nanoparticles loaded with phytochemical agents: potential anti-cancer effects against human lung cancer cells	9
Metabotropic glutamate receptors—guardians and gatekeepers in neonatal hypoxic-ischemic brain injury	9
Mechanistic interplay of various mediators involved in mediating the neuroprotective effect of daphnetin	9
Effect of metformin on the long non-coding RNA expression levels in type 2 diabetes: an in vitro and clinical trial study	9
Sigma receptors and neurological disorders	9
Alcohol and breast cancer	9
Note from editors	9
Proton pump inhibitor on susceptibility to COVID-19 and its severity: a systematic review and meta-analysis	9
5-HT2A receptor- and M1 muscarinic acetylcholine receptor-mediated activation of Gαq/11 in postmortem dorsolateral prefrontal cortex of opiate addicts	8
Treatment with dopamine β-hydroxylase (DBH) inhibitors prevents morphine use and relapse-like behavior in rats	8
Tannic acid enhances cisplatin effect on cell proliferation and apoptosis of human osteosarcoma cell line (U2OS)	8
Critical interactions between opioid and cannabinoid receptors during tolerance and physical dependence development to opioids in the murine gastrointestinal tract: proof of concept	8
Long-term depression-related tau phosphorylation is enhanced by methylene blue in healthy rat hippocampus	8
The application of in silico experimental model in the assessment of ciprofloxacin and levofloxacin interaction with main SARS-CoV-2 targets: S-, E- and TMPRSS2 proteins, RNA-dependent RNA polymerase	8
Glycolytic metabolism supports microglia training during age-related neurodegeneration	8
Alleviating neuropathy of diabetic foot ulcer by co-delivery of venlafaxine and matrix metalloproteinase drug-loaded cellulose nanofiber sheets: production, in vitro characterization and clinical tria	8
Genotyping NUDT15*3 rs1166855232 reveals higher frequency of potential adverse effects of thiopurines in Natives and Mestizos from Mexico	8
Retinoic acid attenuates nuclear factor kappaB mediated induction of NLRP3 inflammasome	8
To aspirate or not to aspirate? Considerations for the COVID-19 vaccines	8
The effects of Sorafenib and Natural killer cell co-injection in combinational treatment of hepatocellular carcinoma; an in vivo approach	7
The impact of the histone deacetylase inhibitor sodium butyrate on microglial polarization after oxygen and glucose deprivation	7
The role of GPR39 zinc receptor in the modulation of glutamatergic and GABAergic transmission	7
Soluble dipeptidyl peptidase-4 induces epithelial–mesenchymal transition through tumor growth factor-β receptor	7
Short-chain fatty acids–microbiota crosstalk in the coronavirus disease (COVID-19)	7
Vascular adhesion protein-1 and microvascular diabetic complications	7
Evaluation of analgesic and anti-inflammatory activity of purine-2,6-dione-based TRPA1 antagonists with PDE4/7 inhibitory activity	7
Cannabidiol attenuates generalized tonic–clonic and suppresses limbic seizures in the genetically epilepsy-prone rats (GEPR-3) strain	7
Effect of common OPRM1, COMT, SLC6A4, ABCB1, and CYP2B6 polymorphisms on perioperative analgesic and propofol demands on patients subjected to thyroidectomy surgery	7
Revisiting the antidepressant-like effects of desipramine in male and female adult rats: sex disparities in neurochemical correlates	7
An update on mode of action of metformin in modulation of meta-inflammation and inflammaging	7
Jacareubin inhibits TLR4-induced lung inflammatory response caused by the RBD domain of SARS-CoV-2 Spike protein	7
Evaluation of nano-curcumin against inhaled paraquat-induced lung injury in rats	7
Identification of mitogen-activated protein kinase phosphatase-1 (MKP-1) protein partners using tandem affinity purification and mass spectrometry	7
Imperatorin interacts additively with novel antiseizure medications in the mouse maximal electroshock-induced seizure model: an isobolographic transformation	6
Neuroprotective effect of apelin-13 and other apelin forms—a review	6
Therapeutic, diagnostic and prognostic values of TRIM proteins in prostate cancer	6
Partial mGlu5 receptor NAM, M-5MPEP, induces rapid and sustained antidepressant-like effects in the BDNF-dependent mechanism and enhances (R)-ketamine action in mice	6
Fast-acting antidepressant-like effects of ketamine in aged male rats	6
Therapeutic effects of S-allyl-L-cysteine in a mouse endometriosis model and its immunomodulatory effects via regulation of T cell subsets and cytokine expression	6
The effect of phencyclidine-mediated blockade of NMDA receptors in the early postnatal period on glutathione and sulfur amino acid levels in the rat brain as a potential causative factor of schizophre	6
Anticonvulsant effects of isopimpinellin and its interactions with classic antiseizure medications and borneol in the mouse tonic–clonic seizure model: an isobolographic transformation	6
The impact of brivaracetam on cognitive processes and anxiety in various experimental models	6
The study of platelet aggregation using a microtiter plate reader ‒ methodological considerations	6
Novel method of measurement of in vitro drug uptake in OATP1B3 overexpressing cells in the presence of dextran	6
β-Carboline derivatives are potent against Acute Myeloid Leukemia in vitro and in vivo	6
Psychedelics action and schizophrenia	6
Extracellular acidification reveals the antiarrhythmic properties of amiodarone related to late sodium current-induced atrial arrhythmia	6
Metabolic and cardiovascular benefits and risks of 4-hydroxy guanabenz hydrochloride: α2-adrenoceptor and trace amine-associated receptor 1 ligand	6
Weighted gene co-expression network analysis for hub genes in colorectal cancer	6
The role of glucagon-like peptide-1/GLP-1R and autophagy in diabetic cardiovascular disease	6
Correction: Protective effect of hygrolansamycin C against corticosterone-induced toxicity and oxidative stress-mediated via autophagy and the MAPK signaling pathway	6
Uncovering the unique characteristics of different groups of 5-HT5AR ligands with reference to their interaction with the target protein	6
The impact of IL-10 and CYP3A5 gene polymorphisms on dose-adjusted trough blood tacrolimus concentrations in early post-renal transplant recipients	6