Protein Engineering Design & Selection

Papers
(The TQCC of Protein Engineering Design & Selection is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)
ArticleCitations
Yeast surface display-based identification of ACE2 mutations that modulate SARS-CoV-2 spike binding across multiple mammalian species47
Enhancing the Thermostability and solubility of a single-domain catalytic antibody29
Improving plastic degrading enzymes via directed evolution24
Cyan fluorescent proteins derived from mNeonGreen20
Comprehensive mapping of SARS-CoV-2 peptide epitopes for development of a highly sensitive serological test for total and neutralizing antibodies20
Dissection of the MeCP2 Repressor Protein Enables CRISPR Platform Optimization via Localization Engineering16
Yeast biopanning against site-specific phosphorylations in tau11
Design of functional intrinsically disordered proteins10
Engineering enzyme activity using an expanded amino acid alphabet9
Enzyme design pioneer Steve Mayo: I was trying to capture the fundamental physics of the problem as a way to elucidate mechanisms9
Engineering of a lysosomal-targeted GAA enzyme9
Sequence-developability mapping of affibody and fibronectin paratopes via library-scale variant characterization8
Modifying pH-sensitive PCSK9/LDLR interactions as a strategy to enhance hepatic cell uptake of low-density lipoprotein cholesterol (LDL-C)7
Antibody-mediated delivery of CRISPR-Cas9 ribonucleoproteins in human cells7
Effect of alanine versus serine at position 88 of human transthyretin mutants on the protein stability6
An easy-to-use high-throughput selection system for the discovery of recombinant protein binders from alternative scaffold libraries6
Analysis of conformational stability of interacting residues in protein binding interfaces6
Engineering of a phosphotriesterase with improved stability and enhanced activity for detoxification of the pesticide metabolite malaoxon6
Structure-based engineering of minimal proline dehydrogenase domains for inhibitor discovery6
Correction to: Protease-stable DARPins as promising oral therapeutics6
abYpap: improvements to the prediction of antibody VH/VL packing using gradient boosted regression6
Physics-based approach to extend a de novo TIM barrel with rationally designed helix-loop-helix motifs6
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