OOIR: Observatory of International Research

Papers

(The H4-Index of Journal of Neuroinflammation is 66. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Maternal immunoglobulin G affects brain development of mouse offspring	491
SARS-CoV-2 spike triggers TLR7-dependent endolysosome dysfunction and senescence in human astrocytes	477
Hypothalamic arcuate microglia in sepsis: AgRP circuit engagement and ARHGAP24-dependent remodeling	430
Correction to: Vagus nerve stimulation modulates hippocampal inflammation caused by continuous stress in rats	298
Correction: Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway	259
Integrin Mac1 mediates paraquat and maneb-induced learning and memory impairments in mice through NADPH oxidase–NLRP3 inflammasome axis-dependent microglial activation	236
Microglia-derived exosomes modulate myelin regeneration via miR-615-5p/MYRF axis	226
IL-7Rα on CD4+ T cells is required for their survival and the pathogenesis of experimental autoimmune encephalomyelitis	208
Phosphatidate phosphatase Lipin1 alters mitochondria-associated endoplasmic reticulum membranes (MAMs) homeostasis: effects which contribute to the development of diabetic encephalopathy	208
The associations between plasma soluble Trem1 and neurological diseases: a Mendelian randomization study	188
The deficient CLEC5A ameliorates the behavioral and pathological deficits via the microglial Aβ clearance in Alzheimer’s disease mouse model	176
Zika virus infection of mature neurons from immunocompetent mice generates a disease-associated microglia and a tauopathy-like phenotype in link with a delayed interferon beta response	148
Inflammation in Neuronal Intranuclear Inclusion Disease (NIID): mechanisms, biomarkers, and therapeutic implications	148
Clonally expanded HSP-specific T cells contribute to glaucomatous neurodegeneration via the mTORC1 pathway	138
HIF1α-dependent hypoxia response in myeloid cells requires IRE1α	132
Carotid artery vascular stenosis causes the blood-CSF barrier damage and neuroinflammation	130
Fractalkine isoforms differentially regulate microglia-mediated inflammation and enhance visual function in the diabetic retina	128
Correction to: Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress	127
Toxoplasma gondii drives myeloid immune cell recruitment to amyloid plaques in Alzheimer’s model mice	127
Cell-intrinsic vulnerability and immune activation cooperate to drive degeneration in a mitochondrial complex I deficiency model of optic neuropathy	121
Peripheral immunosuppressive and immunostimulatory signatures of severity and pain in spinal cord injury	118
Intrauterine inflammation and postnatal intravenous dopamine alter the neurovascular unit in preterm newborn lambs	117
Inhibition of histone deacetylase 6 alleviates neuropathic pain via direct regulating post-translation of spinal STAT3 and decreasing downstream C-C Motif Chemokine Ligand 7 synthesis	113
Tregs dysfunction aggravates postoperative cognitive impairment in aged mice	113
Citrobacter rodentium infection impairs dopamine metabolism and exacerbates the pathology of Parkinson’s disease in mice	112

Integrative imaging and transcriptomics implicate neutrophils in microvascular no-reflow after stroke	110
LXR agonism for CNS diseases: promises and challenges	110
Flow cytometry identifies changes in peripheral and intrathecal lymphocyte patterns in CNS autoimmune disorders and primary CNS malignancies	109
Inflammatory blood-based biomarkers to aid in the assessment and prognostication of traumatic brain injury: a TRACK-TBI study	107
Preoperative gut microbiota of POCD patients induces pre- and postoperative cognitive impairment and systemic inflammation in rats	102
Protein kinase B (AKT) upregulation and Thy-1-αvβ3 integrin-induced phosphorylation of Connexin43 by activated AKT in astrogliosis	100
Altered phenotype and gene expression of regulatory T cells (Tregs) in children with Autism, and the relationship with comorbid gastrointestinal symptoms	97
HMGB1 mediates synaptic loss and cognitive impairment in an animal model of sepsis-associated encephalopathy	96
How the gut microbiota impacts neurodegenerative diseases by modulating CNS immune cells	87
Exercise suppresses neuroinflammation for alleviating Alzheimer’s disease	86
Gut microbiota and their influence in brain cancer milieu	86
Therapeutic intervention in neuroinflammation for neovascular ocular diseases through targeting the cGAS-STING-necroptosis pathway	84
Extracellular vesicles produced by HIV-1 Nef-expressing cells induce myelin impairment and oligodendrocyte damage in the mouse central nervous system	83
Elucidating the specific mechanisms of the gut-brain axis: the short-chain fatty acids-microglia pathway	83
TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway	83
Inhibition of neutrophil extracellular traps alleviates blood–brain barrier disruption and cognitive dysfunction via Wnt3/β-catenin/TCF4 signaling in sepsis-associated encephalopathy	82
Neuroimmune programming of childhood trauma: comorbid mechanisms and developmental origins of depression and autoimmune diseases	81
Selective neuronal expression of progranulin is sufficient to provide neuroprotective and anti-inflammatory effects after traumatic brain injury	80
Nanoparticulate MgH2 ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress	78
Immune imbalance between T helper 1, T helper 17 and regulatory T cells fuels amyotrophic lateral sclerosis pathogenesis: disease trajectory, diagnosis and therapeutic implications	77
NLRX1 limits inflammatory neurodegeneration in the anterior visual pathway	77
Profiling the neuroimmune cascade in 3xTg-AD mice exposed to successive mild traumatic brain injuries	76
Chronic rapid eye movement sleep deprivation aggravates the pathogenesis of Alzheimer’s disease by decreasing brain O-GlcNAc cycling in mice	76
Sequential treatment with a TNFR2 agonist and a TNFR1 antagonist improves outcomes in a humanized mouse model for MS	76
CRTH2 is critical for IL-1β-producing B cells during experimental autoimmune encephalomyelitis in mice via p38 signaling	75
Single−cell transcriptomic landscape of sciatic nerve after transection injury	75
Deterioration of neuroimmune homeostasis in Alzheimer’s Disease patients who survive a COVID-19 infection	74
Ubiquitination-mediated upregulation of glycolytic enzyme MCT4 in promoting astrocyte reactivity during neuroinflammation	73
Biomarkers of progressive multiple sclerosis decrease following autologous hematopoietic stem cell transplantation	73
Single-cell RNA sequencing uncovers neutrophil clusters associated with autoimmune neuroinflammation	72
Tumor immunogenicity shapes CNS immune niches and CD8⁺ T cell fate in glioblastoma	72
Cardiac arrest triggers IL-17-mediated neuroinflammation and astrocyte polarization: insights into pathogenesis and intervention	72
Immunotherapy with an antibody against CD1d modulates neuroinflammation in an α-synuclein transgenic model of Lewy body like disease	70
BMAL1-GPX3 axis in the choroid plexus mitigates Aβ pathology in an amyloid mouse model	69
Distinguishing the effects of systemic CSF1R inhibition by PLX3397 on microglia and peripheral immune cells	69
Macrophage exosomal miR-30c-2-3p in atherosclerotic plaques aggravates microglial neuroinflammation during large-artery atherosclerotic stroke via TGF-β/SMAD2 pathway	69
H3K27me3 of Rnf19a promotes neuroinflammatory response during Japanese encephalitis virus infection	68
MST1 promotes microglial pyroptosis and neuroinflammation in alzheimer’s disease by regulating the novel DPP8/NLRP1/Caspase-1/GSDMD-N axis	67
LAPF enhances lysosomal acidification to promote TLR9 and cGAS-STING-mediated antiviral immunity and attenuate HSV-1-induced neuroinflammatory pain	67
Decoding Behcet’s Uveitis: an In-depth review of pathogenesis and therapeutic advances	67
Single-cell RNA sequencing reveals peripheral blood leukocyte responses to spinal cord injury in mice with humanised immune systems	66