OOIR: Observatory of International Research

Papers

(The H4-Index of Journal of Neuroinflammation is 68. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Intrauterine inflammation and postnatal intravenous dopamine alter the neurovascular unit in preterm newborn lambs	539
Correction: Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway	416
Correction to: Vagus nerve stimulation modulates hippocampal inflammation caused by continuous stress in rats	382
Correction to: Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress	368
Zika virus infection of mature neurons from immunocompetent mice generates a disease-associated microglia and a tauopathy-like phenotype in link with a delayed interferon beta response	352
Inhibition of histone deacetylase 6 alleviates neuropathic pain via direct regulating post-translation of spinal STAT3 and decreasing downstream C-C Motif Chemokine Ligand 7 synthesis	263
Flow cytometry identifies changes in peripheral and intrathecal lymphocyte patterns in CNS autoimmune disorders and primary CNS malignancies	233
Integrin Mac1 mediates paraquat and maneb-induced learning and memory impairments in mice through NADPH oxidase–NLRP3 inflammasome axis-dependent microglial activation	194
Inflammation in Neuronal Intranuclear Inclusion Disease (NIID): mechanisms, biomarkers, and therapeutic implications	190
Regulation of the p75 neurotrophin receptor attenuates neuroinflammation and stimulates hippocampal neurogenesis in experimental Streptococcus pneumoniae meningitis	181
Tregs dysfunction aggravates postoperative cognitive impairment in aged mice	178
Fractalkine isoforms differentially regulate microglia-mediated inflammation and enhance visual function in the diabetic retina	153
Maternal immunoglobulin G affects brain development of mouse offspring	144
Extracellular vesicles produced by HIV-1 Nef-expressing cells induce myelin impairment and oligodendrocyte damage in the mouse central nervous system	141
The deficient CLEC5A ameliorates the behavioral and pathological deficits via the microglial Aβ clearance in Alzheimer’s disease mouse model	137
Citrobacter rodentium infection impairs dopamine metabolism and exacerbates the pathology of Parkinson’s disease in mice	135
Argonaute-2 protects the neurovascular unit from damage caused by systemic inflammation	130
Inhibition of neutrophil extracellular traps alleviates blood–brain barrier disruption and cognitive dysfunction via Wnt3/β-catenin/TCF4 signaling in sepsis-associated encephalopathy	121
Therapeutic intervention in neuroinflammation for neovascular ocular diseases through targeting the cGAS-STING-necroptosis pathway	112
Protein kinase B (AKT) upregulation and Thy-1-αvβ3 integrin-induced phosphorylation of Connexin43 by activated AKT in astrogliosis	109
Phosphatidate phosphatase Lipin1 alters mitochondria-associated endoplasmic reticulum membranes (MAMs) homeostasis: effects which contribute to the development of diabetic encephalopathy	107
Marine fungal metabolite butyrolactone I prevents cognitive deficits by relieving inflammation and intestinal microbiota imbalance on aluminum trichloride-injured zebrafish	106
How the gut microbiota impacts neurodegenerative diseases by modulating CNS immune cells	104
Microglia-derived exosomes modulate myelin regeneration via miR-615-5p/MYRF axis	104
TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway	103

Selective neuronal expression of progranulin is sufficient to provide neuroprotective and anti-inflammatory effects after traumatic brain injury	103
HIF1α-dependent hypoxia response in myeloid cells requires IRE1α	97
The associations between plasma soluble Trem1 and neurological diseases: a Mendelian randomization study	95
Macrophage elastase (MMP12) critically contributes to the development of subretinal fibrosis	95
Carotid artery vascular stenosis causes the blood-CSF barrier damage and neuroinflammation	95
Elucidating the specific mechanisms of the gut-brain axis: the short-chain fatty acids-microglia pathway	92
SARS-CoV-2 spike triggers TLR7-dependent endolysosome dysfunction and senescence in human astrocytes	92
Exercise suppresses neuroinflammation for alleviating Alzheimer’s disease	92
HMGB1 mediates synaptic loss and cognitive impairment in an animal model of sepsis-associated encephalopathy	91
Gut microbiota and their influence in brain cancer milieu	91
IL-7Rα on CD4+ T cells is required for their survival and the pathogenesis of experimental autoimmune encephalomyelitis	91
LXR agonism for CNS diseases: promises and challenges	90
Preoperative gut microbiota of POCD patients induces pre- and postoperative cognitive impairment and systemic inflammation in rats	89
Ubiquitination-mediated upregulation of glycolytic enzyme MCT4 in promoting astrocyte reactivity during neuroinflammation	89
Biomarkers of progressive multiple sclerosis decrease following autologous hematopoietic stem cell transplantation	88
NLRX1 limits inflammatory neurodegeneration in the anterior visual pathway	87
Inflammasomes at the crossroads of traumatic brain injury and post-traumatic epilepsy	86
A systematic review of the causes and consequences of spreading depolarization in neuroinflammation; implications for neurovascular disorders	86
Supporting the differential diagnosis of connective tissue diseases with neurological involvement by blood and cerebrospinal fluid flow cytometry	86
Profiling the neuroimmune cascade in 3xTg-AD mice exposed to successive mild traumatic brain injuries	85
Immunotherapy with an antibody against CD1d modulates neuroinflammation in an α-synuclein transgenic model of Lewy body like disease	85
Correction: Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice	84
Single−cell transcriptomic landscape of sciatic nerve after transection injury	82
CRTH2 is critical for IL-1β-producing B cells during experimental autoimmune encephalomyelitis in mice via p38 signaling	81
Decoding Behcet’s Uveitis: an In-depth review of pathogenesis and therapeutic advances	81
Hypochlorous acid derived from microglial myeloperoxidase could mediate high-mobility group box 1 release from neurons to amplify brain damage in cerebral ischemia–reperfusion injury	80
Single-cell RNA sequencing reveals peripheral blood leukocyte responses to spinal cord injury in mice with humanised immune systems	78
Exogenous monocyte myeloid-derived suppressor cells ameliorate immune imbalance, neuroinflammation and cognitive impairment in 5xFAD mice infected with Porphyromonas gingivalis	77
Nisin a probiotic bacteriocin mitigates brain microbiome dysbiosis and Alzheimer’s disease-like neuroinflammation triggered by periodontal disease	76
Sequential treatment with a TNFR2 agonist and a TNFR1 antagonist improves outcomes in a humanized mouse model for MS	76
TLR4-dependent neuroinflammation mediates LPS-driven food-reward alterations during high-fat exposure	76
Remibrutinib (LOU064) inhibits neuroinflammation driven by B cells and myeloid cells in preclinical models of multiple sclerosis	76
AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer’s disease	76
Nanoparticulate MgH2 ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress	74
Deterioration of neuroimmune homeostasis in Alzheimer’s Disease patients who survive a COVID-19 infection	73
Macrophage exosomal miR-30c-2-3p in atherosclerotic plaques aggravates microglial neuroinflammation during large-artery atherosclerotic stroke via TGF-β/SMAD2 pathway	73
Injection of amyloid-β to lateral ventricle induces gut microbiota dysbiosis in association with inhibition of cholinergic anti-inflammatory pathways in Alzheimer’s disease	72
Diffuse traumatic brain injury induced stimulator of interferons (STING) signaling in microglia drives cortical neuroinflammation, neuronal dysfunction, and impaired cognition	71
Distinguishing the effects of systemic CSF1R inhibition by PLX3397 on microglia and peripheral immune cells	71
Chronic rapid eye movement sleep deprivation aggravates the pathogenesis of Alzheimer’s disease by decreasing brain O-GlcNAc cycling in mice	70
IDO1 modulates pain sensitivity and comorbid anxiety in chronic migraine through microglial activation and synaptic pruning	69
H3K27me3 of Rnf19a promotes neuroinflammatory response during Japanese encephalitis virus infection	68
Compromised endothelial Wnt/β-catenin signaling mediates the blood-brain barrier disruption and leads to neuroinflammation in endotoxemia	68