OOIR: Observatory of International Research

Papers

(The H4-Index of Journal of Neuroinflammation is 64. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Maternal immunoglobulin G affects brain development of mouse offspring	527
Correction: Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway	478
Integrin Mac1 mediates paraquat and maneb-induced learning and memory impairments in mice through NADPH oxidase–NLRP3 inflammasome axis-dependent microglial activation	281
The deficient CLEC5A ameliorates the behavioral and pathological deficits via the microglial Aβ clearance in Alzheimer’s disease mouse model	243
Zika virus infection of mature neurons from immunocompetent mice generates a disease-associated microglia and a tauopathy-like phenotype in link with a delayed interferon beta response	238
Inflammation in Neuronal Intranuclear Inclusion Disease (NIID): mechanisms, biomarkers, and therapeutic implications	191
Clonally expanded HSP-specific T cells contribute to glaucomatous neurodegeneration via the mTORC1 pathway	168
Correction to: Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress	161
Citrobacter rodentium infection impairs dopamine metabolism and exacerbates the pathology of Parkinson’s disease in mice	150
Inhibition of histone deacetylase 6 alleviates neuropathic pain via direct regulating post-translation of spinal STAT3 and decreasing downstream C-C Motif Chemokine Ligand 7 synthesis	141
SARS-CoV-2 spike triggers TLR7-dependent endolysosome dysfunction and senescence in human astrocytes	137
Phosphatidate phosphatase Lipin1 alters mitochondria-associated endoplasmic reticulum membranes (MAMs) homeostasis: effects which contribute to the development of diabetic encephalopathy	136
Integrative imaging and transcriptomics implicate neutrophils in microvascular no-reflow after stroke	135
Toxoplasma gondii drives myeloid immune cell recruitment to amyloid plaques in Alzheimer’s model mice	131
Inflammatory blood-based biomarkers to aid in the assessment and prognostication of traumatic brain injury: a TRACK-TBI study	131
The associations between plasma soluble Trem1 and neurological diseases: a Mendelian randomization study	126
TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway	126
Neuroimmune programming of childhood trauma: comorbid mechanisms and developmental origins of depression and autoimmune diseases	123
Therapeutic intervention in neuroinflammation for neovascular ocular diseases through targeting the cGAS-STING-necroptosis pathway	117
Altered phenotype and gene expression of regulatory T cells (Tregs) in children with Autism, and the relationship with comorbid gastrointestinal symptoms	117
HMGB1-mediated endoplasmic reticulum stress in monocyte-derived dendritic cells regulates CD4+ T cell immune responses in myasthenia gravis	117
HIF1α-dependent hypoxia response in myeloid cells requires IRE1α	116
Cell-intrinsic vulnerability and immune activation cooperate to drive degeneration in a mitochondrial complex I deficiency model of optic neuropathy	107
Peripheral immunosuppressive and immunostimulatory signatures of severity and pain in spinal cord injury	106
Intrauterine inflammation and postnatal intravenous dopamine alter the neurovascular unit in preterm newborn lambs	103

Gut microbiota and their influence in brain cancer milieu	96
Preoperative gut microbiota of POCD patients induces pre- and postoperative cognitive impairment and systemic inflammation in rats	96
Hypothalamic arcuate microglia in sepsis: AgRP circuit engagement and ARHGAP24-dependent remodeling	92
Flow cytometry identifies changes in peripheral and intrathecal lymphocyte patterns in CNS autoimmune disorders and primary CNS malignancies	92
CCL5 and CD11b-fibrin interactions regulate microglia migration and morphology in hyperinflammatory experimental cerebral malaria	91
Microglia-derived exosomes modulate myelin regeneration via miR-615-5p/MYRF axis	89
Protein kinase B (AKT) upregulation and Thy-1-αvβ3 integrin-induced phosphorylation of Connexin43 by activated AKT in astrogliosis	88
Fractalkine isoforms differentially regulate microglia-mediated inflammation and enhance visual function in the diabetic retina	88
Tregs dysfunction aggravates postoperative cognitive impairment in aged mice	85
IL-7Rα on CD4+ T cells is required for their survival and the pathogenesis of experimental autoimmune encephalomyelitis	84
LXR agonism for CNS diseases: promises and challenges	83
Exercise suppresses neuroinflammation for alleviating Alzheimer’s disease	83
How the gut microbiota impacts neurodegenerative diseases by modulating CNS immune cells	81
Carotid artery vascular stenosis causes the blood-CSF barrier damage and neuroinflammation	81
Elucidating the specific mechanisms of the gut-brain axis: the short-chain fatty acids-microglia pathway	80
Selective neuronal expression of progranulin is sufficient to provide neuroprotective and anti-inflammatory effects after traumatic brain injury	80
HMGB1 mediates synaptic loss and cognitive impairment in an animal model of sepsis-associated encephalopathy	79
Extracellular vesicles produced by HIV-1 Nef-expressing cells induce myelin impairment and oligodendrocyte damage in the mouse central nervous system	78
Inhibition of neutrophil extracellular traps alleviates blood–brain barrier disruption and cognitive dysfunction via Wnt3/β-catenin/TCF4 signaling in sepsis-associated encephalopathy	78
Nanoparticulate MgH2 ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress	77
Single-cell RNA sequencing uncovers neutrophil clusters associated with autoimmune neuroinflammation	76
Ubiquitination-mediated upregulation of glycolytic enzyme MCT4 in promoting astrocyte reactivity during neuroinflammation	76
H3K27me3 of Rnf19a promotes neuroinflammatory response during Japanese encephalitis virus infection	75
Immunotherapy with an antibody against CD1d modulates neuroinflammation in an α-synuclein transgenic model of Lewy body like disease	75
Lysosomal cholesteryl ester hydrolysis drives white matter repair by reprogramming microglia into a novel reparative state	73
Epigenetic brain reprogramming rejuvenates neuro-immune circuits to reverse Alzheimer’s disease pathology and systemic bone loss	71
Correction: Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice	70
Macrophage exosomal miR-30c-2-3p in atherosclerotic plaques aggravates microglial neuroinflammation during large-artery atherosclerotic stroke via TGF-β/SMAD2 pathway	69
Sequential treatment with a TNFR2 agonist and a TNFR1 antagonist improves outcomes in a humanized mouse model for MS	69
CRTH2 is critical for IL-1β-producing B cells during experimental autoimmune encephalomyelitis in mice via p38 signaling	68
Supporting the differential diagnosis of connective tissue diseases with neurological involvement by blood and cerebrospinal fluid flow cytometry	68
Tumor immunogenicity shapes CNS immune niches and CD8⁺ T cell fate in glioblastoma	68
Exogenous monocyte myeloid-derived suppressor cells ameliorate immune imbalance, neuroinflammation and cognitive impairment in 5xFAD mice infected with Porphyromonas gingivalis	67
Ischemic injury triggers a protective microglial phenotype in models of Aβ pathology	66
Immune imbalance between T helper 1, T helper 17 and regulatory T cells fuels amyotrophic lateral sclerosis pathogenesis: disease trajectory, diagnosis and therapeutic implications	65
LAPF enhances lysosomal acidification to promote TLR9 and cGAS-STING-mediated antiviral immunity and attenuate HSV-1-induced neuroinflammatory pain	65
AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer’s disease	65
Antigen-specific adaptive immunity in Parkinson’s disease: peripheral priming, brain-border reactivation and parenchymal injury	65
α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect	64