FEBS Journal

Article	Citations
	333
Table of Contents	232
Issue Information	215
Table of Contents	195
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Sonic Hedgehog signalling in the regulation of barrier tissue homeostasis and inflammation	135
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The FEBS Journal in 2025: in all science, error precedes the truth	98
Impact of N‐linked glycans on the dual short fibulin/LTBP‐4 axes regulating elastogenesis	97
Exploring the roles of conserved context‐dependent cis‐regulatory elements (cdCREs) in multicellularity, human health and disease	90
The role of the gut microbiome in disorders of gut–brain interaction	89
Intercellular mitochondrial transfer contributes to microenvironmental redirection of cancer cell fate	89
Nizp1 is a specific NUP98‐NSD1 functional interactor that regulates NUP98‐NSD1‐dependent oncogenic programs	87
The biophysical and compositional properties of human basement membranes	87
A novel gyrase inhibitor from toxin–antitoxin system expressed by Staphylococcus aureus	85
On the track of intramembrane clippers: the SPPL2a/b proteases caught in the act in animal models	82
MLDSR, the transcriptional regulator of the major lipid droplets protein MLDS, is controlled by long‐chain fatty acids and contributes to the lipid‐accumulating phenotype in olea	66
Inhibition of epithelial‐to‐mesenchymal transition augments antitumor efficacy of nanotherapeutics in pancreatic ductal adenocarcinoma	61
Regulation of cardiovascular and cardiac functions by caveolins	58
Regulation of bacterial Type III Secretion System export gate opening by substrates and the FliJ stalk of the flagellar ATPase	57
Calcium‐induced structural transitions are central to the folding, function, and processing of serratiopeptidase zymogen into mature form	57
A genome‐wide CRISPR screen identifies USP1 as a novel regulator of the mammalian circadian clock	57

A novel hexameric NADP+‐reducing [FeFe] hydrogenase from Moorella thermoacetica	54
Deciphering the tight metabolite‐level regulation of glucose‐1‐phosphate adenylyltransferase (GlgC) for glycogen synthesis in cyanobacteria	53
Lipofuscin labeling through biorthogonal strain‐promoted azide‐alkyne cycloaddition for the detection of senescent cells	53
The interaction network of the proteasome assembly chaperone PSMD9 regulates proteostasis	52
Pyruvate dehydrogenase phosphatase 1 (PDP1) stimulates HIF activity by supporting histone acetylation under hypoxia	51
The calcium‐sensing receptor alleviates endothelial inflammation in atherosclerosis through regulation of integrin β1‐NLRP3 inflammasome	49
Metabolite‐derived damage‐associated molecular patterns in immunological diseases	47
Site 1 protease aggravates acute kidney injury by promoting tubular epithelial cell ferroptosis through SIRT3‐SOD2‐mtROS signaling	47
A novel allosteric site employs a conserved inhibition mechanism in human kidney‐type glutaminase	46
SMAR1 and p53‐regulated lncRNA RP11‐431M3.1 enhances HIF1A translation via miR‐138 in colorectal cancer cells under oxidative stress	45
Full activation of thermogenesis in brown adipocytes requires Basigin action	44
Protein succinylome analysis identifies citrate synthase as a central regulator of osteoclast metabolic activity	44
Identification and functional analysis of a new type of Z,E‐mixed prenyl reductase from mycobacteria	42
A guide to adhesion GPCR research	42
Succinate receptor 1 signaling mutually depends on subcellular localization and cellular metabolism	41
Obesity, white adipose tissue and cancer	40
CARPs regulate STUB1 and its pathogenic mutants aggregation kinetics by mono‐ubiquitination	40
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Multisubstrate‐based system: a kinetic mechanism study of catechol‐O‐methyltransferase	37
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Salmonella‐driven intestinal edema in mice is characterized by tensed fibronectin fibers	36
Issue Information	36
The CGA codon decoding through tRNAArg(ICG) supply governed by Tad2/Tad3 in Saccharomyces cerevisiae	36
Mlg1, a yeast acyltransferase located in ER membranes associated with mitochondria (MAMs), is involved in de novo synthesis and remodelling of phospholipids	35
Structural features determining the vitamin K epoxide reduction activity in the VKOR family of membrane oxidoreductases	34
Molecular mechanisms and biological roles of GOMED	34
Glow‐type conversion and characterization of a minimal luciferase via mutational analyses	34
Proximal deposition of collagen IV by fibroblasts contributes to basement membrane formation by colon epithelial cells in vitro	33
What's in a name: the multifaceted function of DNA‐ and RNA‐binding proteins in T cell responses	33
New links for meprin β within the protease web	33
AXIN2 is a non‐redundant regulator of AXIN1 stability and β‐catenin in colorectal cancer cells	33
Take a breath: oxygen sensing of epidermal differentiation	33
Synthetic cannabinoid receptor agonists are monoamine oxidase‐A selective inhibitors	32
FAM237A, rather than peptide PEN and proCCK56‐63, binds to and activates the orphan receptor GPR83	32
The mycobacterial guaB1 gene encodes a guanosine 5′‐monophosphate reductase with a cystathionine‐β‐synthase domain	31
Proteolytic cleavage of the TGFβ co‐receptor CD109 changes its conformation, resulting in protease inhibition via activation of its thiol ester, and dissociation from the cell me	31
Correction to “Structural determinants of cold activity and glucose tolerance of a family 1 glycoside hydrolase (GH1) from Antarctic Marinomonas sp. ef1”	31
Ionizing radiation inhibits zebrafish embryo hatching through induction of tissue inhibitors of metalloproteinases (TIMPs) expression	30
The role of lysosomal membrane proteins in autophagy and related diseases	30
Fibrillation of α‐synuclein triggered by bacterial endotoxin and lipid vesicles is modulated by N‐terminal acetylation and familial Parkinson's disease mutations	30
Characterization of multiple lysophosphatidic acid acyltransferases in the plant pathogen Xanthomonas campestris	30
Substrate preference, RNA binding and active site versatility of Stenotrophomonas maltophilia nuclease SmNuc1, explained by a structural study	29
Anchoring of hyaluronan glycocalyx to CD44 reduces sensitivity of HER2‐positive gastric cancer cells to trastuzumab	29

Preferential redox regulation of cysteine‐based protein tyrosine phosphatases: structural and biochemical diversity	29
A major conformational change of N‐terminal helices of Bacillus thuringiensisCry1Ab insecticidal protein is necessary for membrane insertion and toxicity	28
Alternative substrate‐assisted hydrolysis pathways of posttransfer editing by prokaryotic leucyl‐tRNA synthetase	28
A guide to ferroptosis, the biological rust of cellular membranes	28
Biochemical and structural characterization of chlorite dismutase enzyme from Pseudomonas aeruginosa	28
Analysis of mutually exclusive expression in cancer cells identifies a previously unknown intergenic regulatory paradigm	28
Roles and applications of autophagy in guarding against environmental stress and DNA damage in Saccharomyces cerevisiae	28
Navigating centriolar satellites: the role of PCM1 in cellular and organismal processes	27
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RAGE induces physiological activation of NADPH oxidase in neurons and astrocytes and neuroprotection	27
Unsaturated fatty acids augment protein transport via the SecA:SecYEG translocon	27
Motif‐driven protein binder design towards transferrin receptor helical domain	27
Functional role of lncRNAs in gastrointestinal malignancies: the peculiar case of small nucleolar RNA host gene family	26
Table of Contents	26
Words of advice: teaching macromolecular crystallography	26
Corrigendum	26
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Cytoskeletal protein Zyxin in embryonic development: from controlling cell movements and pluripotency to regulating embryonic patterning	25
GDH1 exacerbates renal fibrosis by inhibiting the transcriptional activity of peroxisome proliferator‐activated receptor gamma	25
Capturing the RNA castle: Exploiting MicroRNA inhibition for wound healing	25
Structure‐based engineering of a short‐chain cis‐prenyltransferase to biosynthesize nonnatural all‐cis‐polyisoprenoids: molecular mechanisms for primer substrate recognition and ultimate	25
New wine in old bottles: current progress on P5 ATPases	25
Role of the MOZ/MLL‐mediated transcriptional activation system for self‐renewal in normal hematopoiesis and leukemogenesis	25
Biogenesis of fibrils requires C‐mannosylation of PMEL	24
Rafoxanide, a salicylanilide anthelmintic, interacts with human plasma protein transthyretin	24
Proline‐directed yeast and human MAP kinases phosphorylate the Dot1p/DOT1L histone H3K79 methyltransferase	24
Defects of the spliceosomal gene SNRPB affect osteo‐ and chondro‐differentiation	24
Ser38‐His93‐Asn91 triad confers resistance of JFH1 HCV NS5A‐Y93H variant to NS5A inhibitors	24
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Less is better: various means to reduce protein load in the endoplasmic reticulum	23
Issue Information	23
Issue Information	23
Structural and functional insights into the flexible β‐hairpin of glycerol dehydrogenase	23
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11‐Cl‐BBQ, a select modulator of AhR‐regulated transcription, suppresses lung cancer cell growth via activation of p53 and p27Kip1	23
Mosaic translation hypothesis: chimeric polypeptides produced via multiple ribosomal frameshifting as a basis for adaptability	23
ZBTB7A regulates primed‐to‐naïve transition of pluripotent stem cells via recognition of the PNT‐associated sequence by zinc fingers 1–2 and recognition of γ‐globin −200 gene element by zinc fingers 1	22
ENKD1 is a centrosomal and ciliary microtubule‐associated protein important for primary cilium content regulation	22
Identification and structural characterization of a novel acetyl xylan esterase from Aspergillus oryzae	22
LRP1 is the cell‐surface endocytosis receptor for vaspin in adipocytes	22
The ups and downs of elevator‐type di‐/tricarboxylate membrane transporters	21
A novel tdTomato transgenic mouse model to visualize FAP‐positive cancer‐associated fibroblasts	21
Further diversity in the origins of fish antifreeze proteins	21
Structural analysis of the peptidoglycan DL‐endopeptidase CwlO complexed with its inhibitory protein IseA	21
Biophysical investigation of the molecular interaction between minichromosome maintenance protein 6 and Bloom syndrome helicase	21
Impact of structural dynamics on biological functions of flaviviruses	21
Group A Streptococcus interacts with glycosaminoglycans via M proteins to modulate bacterial adherence in vitro	21
Src family kinases (SFKs): critical regulators of microglial homeostatic functions and neurodegeneration in Parkinson's and Alzheimer's diseases	20
Interactions of the maternal microbiome with diet, stress, and infection influence fetal development	20
Physical and functional interactions between LDLR family members and CXCR4 in breast cancer	20
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Augmenter of liver regeneration (ALR) can regulate iron homeostasis through the INOS/NO/SLC39A14 pathway to reduce ferroptosis in acute kidney injury	20
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Structural and interaction analysis of human lipocalin‐type prostaglandin D synthase with the poorly water‐soluble drug NBQX	19
Corrigendum to ‘Cryo‐EM structure of MsbA in saposin‐lipid nanoparticles (Salipro) provides insights into nucleotide coordination’	19
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A year in the molecular life sciences: 2024 highlights	19
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Retraction statement: Quercetin induces endoplasmic reticulum stress to enhance cDDP cytotoxicity in ovarian cancer: involvement of STAT3 signaling	19
Issue Information	19
Rational engineering of AA5_2 copper radical oxidases to probe the molecular determinants governing their substrate selectivity	18
Structure–activity analysis of imino‐pyrimidinone‐fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors	18
Identification of a novel d‐amino acid aminotransferase involved in d‐glutamate biosynthetic pathways in the hyperthermophile Thermotoga maritima	18
Interleukin‐1 family cytokines at the crossroads of microbiome regulation in barrier health and disease	18
Is it possible to measure good science?	18
A comparative study of N‐hydroxylating flavoprotein monooxygenases reveals differences in kinetics and cofactor binding	18
Maize CDKA2;1a and CDKB1;1 kinases have different requirements for their activation and participate in substrate recognition	18
Derivatives of MOPS: promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition	18
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Crystal structure and biophysical characterisation of the enterococcal foldase PpiC, a cross‐opsonic antigen against gram‐positive nosocomial pathogens	18
Lysophospholipid acyltransferase‐mediated formation of saturated glycerophospholipids maintained cell membrane integrity for hypoxic adaptation	17
Nemo‐like kinase blocks myeloid differentiation by targeting tumor suppressor C/EBPα in AML	17
The emerging role of PKM in keratinocyte homeostasis and pathophysiology	17
AKT1 mediates multiple phosphorylation events that functionally promote HSF1 activation	17
Atomic solution structure of Mycobacterium abscessusF‐ATP synthase subunit ε and identification of Ep1MabF1 as a targeted inhibitor	17
Cycloserine enantiomers inhibit PLP‐dependent cysteine desulfurase SufS via distinct mechanisms	17
Comprehensive insulin receptor phosphorylation dynamics profiled by mass spectrometry	17
The m6A demethylase FTO promotes C/EBPβ‐LIP translation to perform oncogenic functions in breast cancer cells	17
Structural insights into α‐(1→6)‐linkage preference of GH97 glucodextranase from Flavobacterium johnsoniae	17

AMPK in the brain: its roles in glucose and neural metabolism	17
Characterisation of an unusual cysteine pair in the Rieske carnitine monooxygenaseCntAcatalytic site	17
Mitochondrial dysfunction and cisplatin sensitivity in gastric cancer: GDF15 as a master player	17
M1‐linked ubiquitination facilitates NF‐κB activation and survival during sterile inflammation	17
The environmental impact of extracellular matrix preparation	17
High dietary protein and fat contents exacerbate hepatic senescence and SASP in mice	17
Tudor staphylococcal nuclease (Tudor‐SN) regulates activation of quiescent hepatic stellate cells	17
Issue Information	16
Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma	16
Effects of senescence on the tumour microenvironment and response to therapy	16
The small molecule ZPD‐2 inhibits the aggregation and seeded polymerisation of C‐terminally truncated α‐Synuclein	16
Gal‐1 promotes lung cancer cell survival by enhancing PARP1/H1.2 interaction to promote DNA repair upon DNA damage response	16
Editor Profile: Nektarios Tavernarakis	16
Issue Information	16
Dual‐Cys bacteriophytochromes: intermediates in cyanobacterial phytochrome evolution?	16
Direct capture, inhibition and crystal structure of HsaD (Rv3569c) from M. tuberculosis	16
Metalloprotease‐mediated cleavage of CD95 ligand	16
Neutrophil extracellular traps boost laser‐induced mouse choroidal neovascularization through the activation of the choroidal endothelial cell TLR4/HIF‐1α pathway	16
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PGE2 pathway mediates oxidative stress‐induced ferroptosis in renal tubular epithelial cells	16
Context‐dependent roles of cellular senescence in normal, aged, and disease states	16
Crystal structures of the SARS‐CoV‐2 nucleocapsid protein C‐terminal domain and development of nucleocapsid‐targeting nanobodies	16
Gut microbiota in multiple sclerosis and animal models	16
Phosphatidic acid induces cytoskeletal rearrangements through the Src‐FAK‐RhoA/ROCK signaling pathway during decidualization	16
Evidence for corrin biosynthesis in the last universal common ancestor	16
Sox9/CXCL5 axis facilitates tumour cell growth and invasion in hepatocellular carcinoma	15
Dietary restriction and lifespan: adaptive reallocation or somatic sacrifice?	15
Cell wall‐resident proteins with internal repeats (PIRs) show an inverted architecture in Neurospora crassa, but maintain their role as wall stabilizers	15
Biogenesis of hepatitis B virus e antigen is driven by translocon‐associated protein complex and regulated by conserved cysteine residues within its signal peptide sequence	15
The c‐di‐AMP‐binding protein CbpB modulates the level of ppGpp alarmone in Streptococcus agalactiae	15
Mitochondrial dysfunction decreases cisplatin sensitivity in gastric cancer cells through upregulation of integrated stress response and mitokine GDF15	15
Metal ion activation and DNA recognition by the Deinococcus radiodurans manganese sensor DR2539	15
Understanding HAIs: Ally proteins in the fight against cancer	15
Role of the polycystic kidney disease domain in matriptase chaperone activity and localization of hepatocyte growth factor activator inhibitor‐1	15
Rewarding excellence: the 2024 FEBS Journal Richard Perham prize	15
The dual roles of three MMPs and TIMP in innate immunity and metamorphosis in the silkworm, Bombyx mori	15
Membrane anchoring of New Delhi metallo‐β‐lactamase‐1 alters the fitness of Escherichia coli and increases its susceptibility to colistin by inducing outer membrane destabilization	14
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Association of 2‐oxoacid dehydrogenase complexes with respirasomes in mitochondria	14
Inhibition of intracellular versus extracellular cathepsin D differentially alters the liver lipidome of mice with metabolic dysfunction‐associated steatohepatitis	14
Responses of animals and plants to physiological doses of ethanol: a molecular messenger of hypoxia?	14
Issue Information	14
Issue Information	14
GSH facilitates the binding and inhibitory activity of novel multidrug resistance protein 1 (MRP1) modulators	14
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Pinocembrin alleviates renal ischemia–reperfusion injury/unilateral ureteral obstruction (UUO)‐generated renal fibrosis by targeting the CYP1B1/ROS/MAPK axi	14
Editor Profile: Daniel Longley	14
The role of compartmentalized β‐AR/cAMP signaling in the regulation of lipolysis in white and brown adipocytes	14
Issue Information	14
Sortilin regulates blood–brain barrier integrity	14
Electrostatic potential as a reactivity scoring function in computer‐assisted enzyme engineering	14
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One ring closer to a closure: the crystal structure of the ES3 hydroxymethylbilane synthase intermediate	13
Multi‐omics characterization of synthetic lethality‐related molecular features: implications for SL‐based therapeutic target screening	13
New insights into the mechanism of iron transport through the bacterial Ftr system present in pathogens	13
Staufen‐2 functions as a cofactor for enhanced Rev‐mediated nucleocytoplasmic trafficking of HIV‐1 genomic RNA via the CRM1 pathway	13
Interaction with the cysteine‐free protein HAX1 expands the substrate specificity and function of MIA40 beyond protein oxidation	13
Regulation of basal autophagy by calmodulin availability	13
Deciphering the structure and mechanism of action of computer‐designed mastoparan peptides	13
Neurokinin‐1 receptor antagonist rolapitant suppresses anxiety and alcohol intake produced by repeated withdrawal episodes	13
Raft platforms highly enriched in cholesterol: major scaffolds for IL‐6 signalling assembly with implications in inflammation and cancer	13
The chemoreceptor controlling the Wsp‐like transduction pathway in Halomonas titanicaeKHS3 binds and responds to purine derivatives	13
The universal role of adaptive transcription in health and disease	13
Regulation of intrinsic and extrinsic metabolic pathways in tumour‐associated macrophages	13
KIAA0317 regulates SOCS1 stability to ameliorate colonic inflammation	13
A cytosolic disulfide bridge‐supported dimerization is crucial for stability and cellular distribution of Coxsackievirus B3 protein 3A	13
Crystal structures of free and ligand‐bound forms of the TetR/AcrR‐like regulator SCO3201 from Streptomyces coelicolor suggest a novel allosteric mechanism	13
Oxidative stress‐induced YAP1 expression is regulated by NCE102, CDA2, and BCS1	13
Insights into the mechanisms of neuron generation and specification in the zebrafish ventral spinal cord	13
Autophagy of the ER: the secretome finds the lysosome	12
GR‐KLF15 pathway controls hepatic lipogenesis during fasting	12
DCBLD2 deletion increases hyperglycemia and induces vascular remodeling by inhibiting insulin receptor recycling in endothelial cells	12
Dysregulated RNA processing and metabolism: a new hallmark of ageing and provocation for cellular senescence	12
Viscosity regulates cell spreading and cell‐extracellular matrix interactions	12
The regulation of liquid‐liquid phase separated condensates containing nucleic acids	12
TBK1 is involved in M‐CSF‐induced macrophage polarization through mediating the IRF5/IRF4 axis	12
Molecular regulators of HOXA9 in acute myeloid leukemia	12
Inner ear organoids: progress and outlook, with a focus on the vascularization	12
Lipid regulation of adenylyl cyclase Rv1625c from Mycobacterium tuberculosis by its membrane‐domain receptor	12
Therapeutic opportunities for senolysis in cardiovascular disease	12
Tryptophan and its metabolites in normal physiology and cancer etiology	12
Tracing the evolutionary pathway: on the origin of mitochondria and eukaryogenesis	12
Issue Information	12
Identification of an exosite at the neutrophil elastase/alpha‐1‐antitrypsin interface	12
Chromatin folding by the Polycomb group proteins and its elusive role in epigenetic repression	12
A metastasis‐associated pannexin‐1 mutant (Panx11‐89) forms a minimalist ATP release channel	12
Mitochondrial derived vesicles‐ Quo Vadis?	12
Phytoplankton cell‐states: multiparameter fluorescence lifetime flow‐based monitoring reveals cellular heterogeneity	12
Structural dynamics of the N‐terminal SH2 domain of PI3K in its free and CD28‐bound states	12
The critical role of the aldehyde dehydrogenase PauC in spermine, spermidine, and diaminopropane toxicity in Pseudomonas aeruginosa: Its possible use as a drug target	12
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N‐acetylglucosamine sensing in the filamentous soil fungus Trichoderma reesei	11