OOIR: Observatory of International Research

Papers

(The median citation count of FEBS Journal is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
	412
Table of Contents	297
Issue Information	214
Table of Contents	187
	176
Table of Contents	154
Table of Contents	140
Table of Contents	123
	117
The FEBS Journal in 2025: in all science, error precedes the truth	111
The calcium‐sensing receptor alleviates endothelial inflammation in atherosclerosis through regulation of integrin β1‐NLRP3 inflammasome	100
Protein succinylome analysis identifies citrate synthase as a central regulator of osteoclast metabolic activity	97
Succinate receptor 1 signaling mutually depends on subcellular localization and cellular metabolism	96
Nizp1 is a specific NUP98‐NSD1 functional interactor that regulates NUP98‐NSD1‐dependent oncogenic programs	89
A novel gyrase inhibitor from toxin–antitoxin system expressed by Staphylococcus aureus	88
On the track of intramembrane clippers: the SPPL2a/b proteases caught in the act in animal models	86
CARPs regulate STUB1 and its pathogenic mutants aggregation kinetics by mono‐ubiquitination	82
Full activation of thermogenesis in brown adipocytes requires Basigin action	82
MLDSR, the transcriptional regulator of the major lipid droplets protein MLDS, is controlled by long‐chain fatty acids and contributes to the lipid‐accumulating phenotype in olea	81
Sonic Hedgehog signalling in the regulation of barrier tissue homeostasis and inflammation	81
SMAR1 and p53‐regulated lncRNA RP11‐431M3.1 enhances HIF1A translation via miR‐138 in colorectal cancer cells under oxidative stress	81
Probing invadosomes: technologies for the analysis of invadosomes	80
Inhibition of epithelial‐to‐mesenchymal transition augments antitumor efficacy of nanotherapeutics in pancreatic ductal adenocarcinoma	79
Regulation of cardiovascular and cardiac functions by caveolins	78
A novel hexameric NADP⁺‐reducing [FeFe] hydrogenase from Moorella thermoacetica	76

A genome‐wide CRISPR screen identifies USP1 as a novel regulator of the mammalian circadian clock	72
Regulation of bacterial Type III Secretion System export gate opening by substrates and the FliJ stalk of the flagellar ATPase	71
Identification and functional analysis of a new type of Z,E‐mixed prenyl reductase from mycobacteria	67
Calcium‐induced structural transitions are central to the folding, function, and processing of serratiopeptidase zymogen into mature form	63
Acidic pH irreversibly activates the signaling enzyme SARM1	60
Spatial and temporal key steps in early‐life intestinal immune system development and education	60
Metabolite‐derived damage‐associated molecular patterns in immunological diseases	59
Lipofuscin labeling through biorthogonal strain‐promoted azide‐alkyne cycloaddition for the detection of senescent cells	56
LRRK2 recruitment, activity, and function in organelles	55
The role of the gut microbiome in disorders of gut–brain interaction	55
Deciphering the tight metabolite‐level regulation of glucose‐1‐phosphate adenylyltransferase (GlgC) for glycogen synthesis in cyanobacteria	55
The interaction network of the proteasome assembly chaperone PSMD9 regulates proteostasis	54
A guide to adhesion GPCR research	54
Pyruvate dehydrogenase phosphatase 1 (PDP1) stimulates HIF activity by supporting histone acetylation under hypoxia	53
A novel allosteric site employs a conserved inhibition mechanism in human kidney‐type glutaminase	53
Site 1 protease aggravates acute kidney injury by promoting tubular epithelial cell ferroptosis through SIRT3‐SOD2‐mtROS signaling	52
The biophysical and compositional properties of human basement membranes	52
Obesity, white adipose tissue and cancer	52
Matrix metalloproteinase‐13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha‐1 antitrypsin: Implications for osteoarthritis	50
Intercellular mitochondrial transfer contributes to microenvironmental redirection of cancer cell fate	50
	49
	48
Table of Contents	46
	45
Anchoring of hyaluronan glycocalyx to CD44 reduces sensitivity of HER2‐positive gastric cancer cells to trastuzumab	45
Table of Contents	45
Table of Contents	45
Table of Contents	43
Table of Contents	43
Multisubstrate‐based system: a kinetic mechanism study of catechol‐O‐methyltransferase	41
	41
	40
Issue Information	40
Analysis of mutually exclusive expression in cancer cells identifies a previously unknown intergenic regulatory paradigm	39
Navigating centriolar satellites: the role of PCM1 in cellular and organismal processes	38
Inflammatory cell death induced by cytotoxic lymphocytes: a dangerous but necessary liaison	37
Substrate preference, RNA binding and active site versatility of Stenotrophomonas maltophilia nuclease SmNuc1, explained by a structural study	37
Roles and applications of autophagy in guarding against environmental stress and DNA damage in Saccharomyces cerevisiae	37
Characterization of multiple lysophosphatidic acid acyltransferases in the plant pathogen Xanthomonas campestris	36
Mlg1, a yeast acyltransferase located in ER membranes associated with mitochondria (MAMs), is involved in de novo synthesis and remodelling of phospholipids	36
Glow‐type conversion and characterization of a minimal luciferase via mutational analyses	36
Correction to “Structural determinants of cold activity and glucose tolerance of a family 1 glycoside hydrolase (GH1) from Antarctic Marinomonas sp. ef1”	36
Molecular mechanisms and biological roles of GOMED	36
Fibrillation of α‐synuclein triggered by bacterial endotoxin and lipid vesicles is modulated by N‐terminal acetylation and familial Parkinson's disease mutations	36
Ionizing radiation inhibits zebrafish embryo hatching through induction of tissue inhibitors of metalloproteinases (TIMPs) expression	36
The mycobacterial guaB1 gene encodes a guanosine 5′‐monophosphate reductase with a cystathionine‐β‐synthase domain	35
New links for meprin β within the protease web	35
Preferential redox regulation of cysteine‐based protein tyrosine phosphatases: structural and biochemical diversity	35
Proximal deposition of collagen IV by fibroblasts contributes to basement membrane formation by colon epithelial cells in vitro	35
Structural features determining the vitamin K epoxide reduction activity in the VKOR family of membrane oxidoreductases	35

Synthetic cannabinoid receptor agonists are monoamine oxidase‐A selective inhibitors	34
A major conformational change of N‐terminal helices of Bacillus thuringiensisCry1Ab insecticidal protein is necessary for membrane insertion and toxicity	34
AXIN2 is a non‐redundant regulator of AXIN1 stability and β‐catenin in colorectal cancer cells	33
What's in a name: the multifaceted function of DNA‐ and RNA‐binding proteins in T cell responses	33
Histatin‐1 is an endogenous ligand of the sigma‐2 receptor	33
Take a breath: oxygen sensing of epidermal differentiation	33
Motif‐driven protein binder design towards transferrin receptor helical domain	32
RAGE induces physiological activation of NADPH oxidase in neurons and astrocytes and neuroprotection	32
Proteolytic cleavage of the TGFβ co‐receptor CD109 changes its conformation, resulting in protease inhibition via activation of its thiol ester, and dissociation from the cell me	32
Acetylation of the influenza A virus polymerase subunit PA in the N‐terminal domain positively regulates its endonuclease activity	32
Unsaturated fatty acids augment protein transport via the SecA:SecYEG translocon	32
The Immunity‐malignancy equilibrium in multiple myeloma: lessons from oncogenic events in plasma cells	32
PRL‐3 promotes a positive feedback loop between STAT1/2‐induced gene expression and glycolysis in multiple myeloma	31
The CGA codon decoding through tRNA^Arg(ICG) supply governed by Tad2/Tad3 in Saccharomyces cerevisiae	31
Eat, sleep, repeat – endocrine regulation of behavioural circadian rhythms	31
The largely unexplored biology of small proteins in pro‐ and eukaryotes	31
Salmonella‐driven intestinal edema in mice is characterized by tensed fibronectin fibers	31
A guide to ferroptosis, the biological rust of cellular membranes	30
The role of understudied post‐translational modifications for the behavior and function of Signal Transducer and Activator of Transcription 3	30
The role of lysosomal membrane proteins in autophagy and related diseases	30
	29
Augmenter of liver regeneration (ALR) can regulate iron homeostasis through the INOS/NO/SLC39A14 pathway to reduce ferroptosis in acute kidney injury	29
	29
Table of Contents	29
Table of Contents	29
Corrigendum	29
FAM237A, rather than peptide PEN and proCCK56‐63, binds to and activates the orphan receptor GPR83	29
Words of advice: teaching macromolecular crystallography	28
Functional role of lncRNAs in gastrointestinal malignancies: the peculiar case of small nucleolar RNA host gene family	28
Structure‐based engineering of a short‐chain cis‐prenyltransferase to biosynthesize nonnatural all‐cis‐polyisoprenoids: molecular mechanisms for primer substrate recognition and ultimate	28
Capturing the RNA castle: Exploiting MicroRNA inhibition for wound healing	27
The ups and downs of elevator‐type di‐/tricarboxylate membrane transporters	27
Role of the MOZ/MLL‐mediated transcriptional activation system for self‐renewal in normal hematopoiesis and leukemogenesis	27
GDH1 exacerbates renal fibrosis by inhibiting the transcriptional activity of peroxisome proliferator‐activated receptor gamma	27
Src family kinases (SFKs): critical regulators of microglial homeostatic functions and neurodegeneration in Parkinson's and Alzheimer's diseases	27
Cytoskeletal protein Zyxin in embryonic development: from controlling cell movements and pluripotency to regulating embryonic patterning	26
Mosaic translation hypothesis: chimeric polypeptides produced via multiple ribosomal frameshifting as a basis for adaptability	26
New wine in old bottles: current progress on P5 ATPases	26
Proline‐directed yeast and human MAP kinases phosphorylate the Dot1p/DOT1L histone H3K79 methyltransferase	26
Further diversity in the origins of fish antifreeze proteins	26
Ser38‐His93‐Asn91 triad confers resistance of JFH1 HCV NS5A‐Y93H variant to NS5A inhibitors	26
Biogenesis of fibrils requires C‐mannosylation of PMEL	25
	25
Rafoxanide, a salicylanilide anthelmintic, interacts with human plasma protein transthyretin	25
	25
Defects of the spliceosomal gene SNRPB affect osteo‐ and chondro‐differentiation	25
Structural and functional insights into the flexible β‐hairpin of glycerol dehydrogenase	25
Issue Information	25
Issue Information	24
Interactions of the maternal microbiome with diet, stress, and infection influence fetal development	24
LRP1 is the cell‐surface endocytosis receptor for vaspin in adipocytes	23
ZBTB7A regulates primed‐to‐naïve transition of pluripotent stem cells via recognition of the PNT‐associated sequence by zinc fingers 1–2 and recognition of γ‐globin −200 gene element by zinc fingers 1	23
Physical and functional interactions between LDLR family members and CXCR4 in breast cancer	23
Impact of structural dynamics on biological functions of flaviviruses	23
Structural analysis of the peptidoglycan DL‐endopeptidase CwlO complexed with its inhibitory protein IseA	23
A novel tdTomato transgenic mouse model to visualize FAP‐positive cancer‐associated fibroblasts	23
Biophysical investigation of the molecular interaction between minichromosome maintenance protein 6 and Bloom syndrome helicase	23
Identification and structural characterization of a novel acetyl xylan esterase from Aspergillus oryzae	23
ENKD1 is a centrosomal and ciliary microtubule‐associated protein important for primary cilium content regulation	23
Less is better: various means to reduce protein load in the endoplasmic reticulum	23
11‐Cl‐BBQ, a select modulator of AhR‐regulated transcription, suppresses lung cancer cell growth via activation of p53 and p27^Kip1	23
Tudor staphylococcal nuclease (Tudor‐SN) regulates activation of quiescent hepatic stellate cells	22
	22
Issue Information	22
	22
	22
	22
Retraction statement: Quercetin induces endoplasmic reticulum stress to enhance cDDP cytotoxicity in ovarian cancer: involvement of STAT3 signaling	21
Derivatives of MOPS: promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition	21
Comprehensive insulin receptor phosphorylation dynamics profiled by mass spectrometry	21
Maize CDKA2;1a and CDKB1;1 kinases have different requirements for their activation and participate in substrate recognition	21
Phosphatidic acid induces cytoskeletal rearrangements through the Src‐FAK‐RhoA/ROCK signaling pathway during decidualization	21
Corrigendum to ‘Cryo‐EM structure of MsbA in saposin‐lipid nanoparticles (Salipro) provides insights into nucleotide coordination’	21
Atomic solution structure of Mycobacterium abscessusF‐ATP synthase subunit ε and identification of Ep1MabF1 as a targeted inhibitor	21
Structure–activity analysis of imino‐pyrimidinone‐fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors	21
A year in the molecular life sciences: 2024 highlights	21
High dietary protein and fat contents exacerbate hepatic senescence and SASP in mice	21
Evidence for corrin biosynthesis in the last universal common ancestor	21
Is it possible to measure good science?	21
A comparative study of N‐hydroxylating flavoprotein monooxygenases reveals differences in kinetics and cofactor binding	21

A guide to changing paradigms of glucocorticoid receptor function—a model system for genome regulation and physiology	20
Structural and interaction analysis of human lipocalin‐type prostaglandin D synthase with the poorly water‐soluble drug NBQX	20
No small matter: emerging roles for exosomal miRNAs in the immune system	20
Rational engineering of AA5_2 copper radical oxidases to probe the molecular determinants governing their substrate selectivity	20
Lysophospholipid acyltransferase‐mediated formation of saturated glycerophospholipids maintained cell membrane integrity for hypoxic adaptation	20
Mitochondrial dysfunction and cisplatin sensitivity in gastric cancer: GDF15 as a master player	20
Gal‐1 promotes lung cancer cell survival by enhancing PARP1/H1.2 interaction to promote DNA repair upon DNA damage response	19
Nemo‐like kinase blocks myeloid differentiation by targeting tumor suppressor C/EBPα in AML	19
The m6A demethylase FTO promotes C/EBPβ‐LIP translation to perform oncogenic functions in breast cancer cells	19
	19
M1‐linked ubiquitination facilitates NF‐κB activation and survival during sterile inflammation	19
The environmental impact of extracellular matrix preparation	19
Neutrophil extracellular traps boost laser‐induced mouse choroidal neovascularization through the activation of the choroidal endothelial cell TLR4/HIF‐1α pathway	19
AKT1 mediates multiple phosphorylation events that functionally promote HSF1 activation	19
Characterisation of an unusual cysteine pair in the Rieske carnitine monooxygenaseCntAcatalytic site	19
Structural insights into α‐(1→6)‐linkage preference of GH97 glucodextranase from Flavobacterium johnsoniae	19
Bidirectional feedback between BCR signaling and actin cytoskeletal dynamics	19
Contributions of PD‐L1 reverse signaling to dendritic cell trafficking	19
Interleukin‐1 family cytokines at the crossroads of microbiome regulation in barrier health and disease	19
Cycloserine enantiomers inhibit PLP‐dependent cysteine desulfurase SufS via distinct mechanisms	19
Identification of a novel d‐amino acid aminotransferase involved in d‐glutamate biosynthetic pathways in the hyperthermophile Thermotoga maritima	19
Editor Profile: Nektarios Tavernarakis	18
The small molecule ZPD‐2 inhibits the aggregation and seeded polymerisation of C‐terminally truncated α‐Synuclein	18
The emerging role of PKM in keratinocyte homeostasis and pathophysiology	18
Issue Information	18
Dual‐Cys bacteriophytochromes: intermediates in cyanobacterial phytochrome evolution?	18
AMPK in the brain: its roles in glucose and neural metabolism	18
	18
Issue Information	18
Crystal structures of the SARS‐CoV‐2 nucleocapsid protein C‐terminal domain and development of nucleocapsid‐targeting nanobodies	17
Electrostatic potential as a reactivity scoring function in computer‐assisted enzyme engineering	17
Mitochondrial dysfunction decreases cisplatin sensitivity in gastric cancer cells through upregulation of integrated stress response and mitokine GDF15	17
Role of the polycystic kidney disease domain in matriptase chaperone activity and localization of hepatocyte growth factor activator inhibitor‐1	17
GSH facilitates the binding and inhibitory activity of novel multidrug resistance protein 1 (MRP1) modulators	17
Metalloprotease‐mediated cleavage of CD95 ligand	17
Metal ion activation and DNA recognition by the Deinococcus radiodurans manganese sensor DR2539	17
The dual roles of three MMPs and TIMP in innate immunity and metamorphosis in the silkworm, Bombyx mori	17
Understanding HAIs: Ally proteins in the fight against cancer	17
Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma	17
The c‐di‐AMP‐binding protein CbpB modulates the level of ppGpp alarmone in Streptococcus agalactiae	17
Synaptic effects of ethanol on striatal circuitry: therapeutic implications for dystonia	17
Biogenesis of hepatitis B virus e antigen is driven by translocon‐associated protein complex and regulated by conserved cysteine residues within its signal peptide sequence	17
Dietary restriction and lifespan: adaptive reallocation or somatic sacrifice?	16
Gut microbiota in multiple sclerosis and animal models	16
Direct capture, inhibition and crystal structure of HsaD (Rv3569c) from M. tuberculosis	16
Effects of senescence on the tumour microenvironment and response to therapy	16
Sox9/CXCL5 axis facilitates tumour cell growth and invasion in hepatocellular carcinoma	16
Issue Information	16
Rewarding excellence: the 2024 FEBS Journal Richard Perham prize	16
Context‐dependent roles of cellular senescence in normal, aged, and disease states	16
PAM: diverse roles in neuroendocrine cells, cardiomyocytes, and green algae	16
tRNA‐like structures and their functions	16
Table of Contents	16
TBK1 is involved in M‐CSF‐induced macrophage polarization through mediating the IRF5/IRF4 axis	16
Sortilin regulates blood–brain barrier integrity	16
PGE2 pathway mediates oxidative stress‐induced ferroptosis in renal tubular epithelial cells	16
Cell wall‐resident proteins with internal repeats (PIRs) show an inverted architecture in Neurospora crassa, but maintain their role as wall stabilizers	16
Recent advances on smart glycoconjugate vaccines in infections and cancer	16
Table of Contents	16
Association of 2‐oxoacid dehydrogenase complexes with respirasomes in mitochondria	15
Issue Information	15
Table of Contents	15
The role of compartmentalized β‐AR/cAMP signaling in the regulation of lipolysis in white and brown adipocytes	15
Inhibition of intracellular versus extracellular cathepsin D differentially alters the liver lipidome of mice with metabolic dysfunction‐associated steatohepatitis	15
Tracing the evolutionary pathway: on the origin of mitochondria and eukaryogenesis	15
Responses of animals and plants to physiological doses of ethanol: a molecular messenger of hypoxia?	15
Issue Information	15
	15
Pinocembrin alleviates renal ischemia–reperfusion injury/unilateral ureteral obstruction (UUO)‐generated renal fibrosis by targeting the CYP1B1/ROS/MAPK axi	15
Editor Profile: Daniel Longley	15
One ring closer to a closure: the crystal structure of the ES₃ hydroxymethylbilane synthase intermediate	15
Membrane anchoring of New Delhi metallo‐β‐lactamase‐1 alters the fitness of Escherichia coli and increases its susceptibility to colistin by inducing outer membrane destabilization	15
A metastasis‐associated pannexin‐1 mutant (Panx1^1‐89) forms a minimalist ATP release channel	15
	15
Viscosity regulates cell spreading and cell‐extracellular matrix interactions	15
Mitochondrial derived vesicles‐ Quo Vadis?	15
Identification of an exosite at the neutrophil elastase/alpha‐1‐antitrypsin interface	15
Multi‐omics characterization of synthetic lethality‐related molecular features: implications for SL‐based therapeutic target screening	14
Neurokinin‐1 receptor antagonist rolapitant suppresses anxiety and alcohol intake produced by repeated withdrawal episodes	14
Dysregulated RNA processing and metabolism: a new hallmark of ageing and provocation for cellular senescence	14
Crystal structures of free and ligand‐bound forms of the TetR/AcrR‐like regulator SCO3201 from Streptomyces coelicolor suggest a novel allosteric mechanism	14
Deciphering the structure and mechanism of action of computer‐designed mastoparan peptides	14
Modeling CSF‐1 receptor deficiency diseases – how close are we?	14
A cytosolic disulfide bridge‐supported dimerization is crucial for stability and cellular distribution of Coxsackievirus B3 protein 3A	14
Raft platforms highly enriched in cholesterol: major scaffolds for IL‐6 signalling assembly with implications in inflammation and cancer	14
Regulation of intrinsic and extrinsic metabolic pathways in tumour‐associated macrophages	14
KIAA0317 regulates SOCS1 stability to ameliorate colonic inflammation	14
The critical role of the aldehyde dehydrogenase PauC in spermine, spermidine, and diaminopropane toxicity in Pseudomonas aeruginosa: Its possible use as a drug target	14
New insights into the mechanism of iron transport through the bacterial Ftr system present in pathogens	14
Regulation of basal autophagy by calmodulin availability	14
Interaction with the cysteine‐free protein HAX1 expands the substrate specificity and function of MIA40 beyond protein oxidation	13
Issue Information	13
Kainate receptors: from synaptic activity to disease	13
Issue Information	13
Molecular regulators of HOXA9 in acute myeloid leukemia	13