OOIR: Observatory of International Research

Papers

(The TQCC of FEBS Journal is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
In conversation with Lori Passmore	365
	266
Full activation of thermogenesis in brown adipocytes requires Basigin action	202
New insights into the structure and function of CNNM proteins	168
Issue Information	160
Issue Information	138
Nucleosome disruption by 5‐bromodeoxyuridine leads to senescence	133
MAEL facilitates metabolic reprogramming and breast cancer progression by promoting the degradation of citrate synthase and fumarate hydratase via chaperone‐mediated autophagy	132
Succinate receptor 1 signaling mutually depends on subcellular localization and cellular metabolism	113
Sea anemone Cys‐ladder peptide Ms13‐1 induces a pain response as a positive modulator of acid‐sensing ion channel 1a	106
Protein biochemistry and engineering drive the development of a carbonic anhydrase‐based carbon dioxide sequestration strategy	106
Enhanced isradipine sensitivity in vascular smooth muscle cells due to hypoxia‐induced Ca_v1.2 splicing and RbFox1/Fox2 downregulation	95
	92
Decoy peptides that inhibit TNF signaling by disrupting the TNF homotrimeric oligomer	91
A tyrosine‐based YXXΦ motif regulates the degradation of aquaporin‐4 via both lysosomal and proteasomal pathways and is functionally inhibited by a 10‐amino‐acid sequence within its C‐termi	91
When more is less: heritable gain‐of‐function chk1 mutations impair human fertility	83
When the host senses the microbiota's metabolism – the interplay between food and microbiota in C. elegans	82
Discovery of a novel alpha isoform of the long‐known enzyme LDHA provides new insights into cancer research	80
Translation regulation in response to stress	80
Issue Information	80
Oncogenic KRAS creates an aspartate metabolism signature in colorectal cancer cells	76
Drugging the circadian clock feedback cycle to ameliorate cartilage degeneration	75
Revisiting catalytic His and Glu residues in coproporphyrin ferrochelatase – unexpected activities of active site variants	75
Microbial recognition regulates intestinal epithelial growth in homeostasis and disease	74
Eukaryotic mRNA decapping factors: molecular mechanisms and activity	74

A new mutation in the Parkinson's‐related FBXO7 gene impairs mitochondrial and proteasomal function	73
Table of Contents	72
Alexander Georgievich Petrenko (1959–2021)	72
Structural analysis of human papillomavirus E6 interactions with Scribble PDZ domains	71
Fusion–fission–mitophagy cycling and metabolic reprogramming coordinate nerve growth factor (NGF)‐dependent neuronal differentiation	70
Professor Dame Janet Thornton to receive ‘The FEBS Journal Open Science Award’	69
	69
Versatile roles of disordered transcription factor effector domains in transcriptional regulation	68
Diel modulation of perireceptor activity influences olfactory sensitivity in diurnal and nocturnal mosquitoes	67
	62
Emerging paradigms in activation, signaling, and regulation of G protein‐coupled receptors	62
Munc18 − Munc13‐dependent pathway of SNARE complex assembly is resistant to NSF and α‐SNAP	60
	60
Stem‐cell based, machine learning approach for optimizing natural killer cell‐based personalized immunotherapy for high‐grade ovarian cancer	58
Direct interaction between mortalin and HIF‐1α at the mitochondria inhibits apoptosis by blocking recruitment of Bax	58
More important than ever: understanding how plants cope with stress	56
Issue Information	53
Wilavidin* — a novel member of the avidin family that forms unique biotin‐binding hexamers	53
Membrane protein biogenesis at the ER: the highways and byways	53
Table of Contents	52
Table of Contents	52
Metabolic rewiring: a new master of Th17 cell plasticity and heterogeneity	51
Endothelial cell diversity: the many facets of the crystal	51
Lipofuscin labeling through biorthogonal strain‐promoted azide‐alkyne cycloaddition for the detection of senescent cells	51
Starvation resistance in planarians: multiple strategies to get a thrifty phenotype	51
Acidic pH irreversibly activates the signaling enzyme SARM1	51
Structural comparison of (hyper‐)thermophilic nitrogenase reductases from three marine Methanococcales	50
Structural alteration of the nucleus for the reprogramming of gene expression	50
Functional and structural characterization of an IclR family transcription factor for the development of dicarboxylic acid biosensors	50
Regulation of bacterial Type III Secretion System export gate opening by substrates and the FliJ stalk of the flagellar ATPase	49
Protein engineering using circular permutation – structure, function, stability, and applications	47
Extracellular vesicles promote autophagy in human microglia through lipid raft‐dependent mechanisms	46
The archaeal highly thermostable GH35 family β‐galactosidase DaβGal has a unique seven domain protein fold	46
Issue Information	46
Table of Contents	45
Table of Contents	45
The FEBS Journal in 2022: trust the science and treasure the data	44
Meeting report of the 4th biennial Metabolism and Cancer symposium	44
Table of Contents	44
Table of Contents	43
Table of Contents	42
	42
Enzymatic lysine oxidation as a posttranslational modification	41
Table of Contents	41
Notch signalling: multifaceted role in development and disease	40
Only one carbon difference determines the pro‐apoptotic activity of α‐tocopheryl esters	39
A guide to UFMylation, an emerging posttranslational modification	39
Glycaemic sugar metabolism and the gut microbiota: past, present and future	38
Issue Information	38
The role of the gut microbiota in regulating responses to vaccination: current knowledge and future directions	38

Dr. Alexander Wlodawer—celebrating five decades of service to the structural biology community	37
Issue Information	37
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	37
Enhanced translocation of TRIM32 to mitochondria sensitizes dopaminergic neuronal cells to apoptosis during stress conditions in Parkinson's disease	36
Site 1 protease aggravates acute kidney injury by promoting tubular epithelial cell ferroptosis through SIRT3‐SOD2‐mtROS signaling	36
A novel allosteric site employs a conserved inhibition mechanism in human kidney‐type glutaminase	36
Advances and challenges in understanding endosomal sorting and fission	36
	35
Enzymology of reactive intermediate protection: kinetic analysis and temperature dependence of the mesophilic membrane protein catalyst MGST1	34
A novel gyrase inhibitor from toxin–antitoxin system expressed by Staphylococcus aureus	34
SRPK1 regulates RNA binding in a pre‐spliceosomal complex using a catalytic bypass mechanism	33
Issue Information	33
Issue Information	33
Metabolic switching of estrogen‐related receptor alpha in breast cancer aggression	33
On the track of intramembrane clippers: the SPPL2a/b proteases caught in the act in animal models	33
Store‐operated calcium entry inhibits primary ciliogenesis via the activation of Aurora A	33
Cholesterol stimulates the lytic activity of Adenylate Cyclase Toxin on lipid membranes by promoting toxin oligomerization and formation of pores with a greater effective size	33
CDC7 inhibition drives an inflammatory response and a p53‐dependent senescent‐like state in breast epithelial cells	32
Issue Information	31
Calcium‐induced structural transitions are central to the folding, function, and processing of serratiopeptidase zymogen into mature form	31
Table of Contents	31
Table of Contents	31
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	31
Liquid–liquid phase separation of alpha‐synuclein increases the structural variability of fibrils formed during amyloid aggregation	30
Skeletal muscle‐enriched miRNAs are highly unstable in vivo and may be regulated in a Dicer‐independent manner	30
Ubiquitin signalling in Drosophila innate immune responses	30
Interplay between mammalian heat shock factors 1 and 2 in physiology and pathology	30
Distinct binding kinetics of E‐, P‐ and L‐selectins to CD44	30
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PotN represents a novel energy‐state sensing PII subfamily, occurring in firmicutes	30
Enzyme nomenclature and classification: the state of the art	29
The functional role of Ire1 in regulating autophagy and proteasomal degradation under prolonged proteotoxic stress	29
CARPs regulate STUB1 and its pathogenic mutants aggregation kinetics by mono‐ubiquitination	29
Immature acute leukaemias: lessons from the haematopoietic roadmap	29
Effects of natural RNA modifications on the activity of SARS‐CoV‐2 RNA‐dependent RNA polymerase	29
Fatty‐acid amide hydrolase inhibition mitigates Alzheimer's disease progression in mouse models of amyloidosis	29
Pyruvate dehydrogenase phosphatase 1 (PDP1) stimulates HIF activity by supporting histone acetylation under hypoxia	29
In conversation with Carol Robinson	28
Cellular senescence as a source of SARS‐CoV‐2 quasispecies	28
Bacterial purine metabolism modulates C. elegans development and stress tolerance via DAF‐16	28
Immune sensing of mouse polyomavirus DNA by p204 and cGAS DNA sensors	28
Intercellular mitochondrial transfer contributes to microenvironmental redirection of cancer cell fate	28
HDAC6 inhibition upregulates endothelial SOD3 expression via Sp1 acetylation and attenuates angiotensin II‐induced hypertension	28
Hydromethylthionine sustains truncated tau‐dependent inflammation‐lowering effects in mouse brain	28
A guide to adhesion GPCR research	28
Hypoxia‐induced translation of collagen‐modifying enzymes PLOD2 and P4HA1 is dependent on RBM4 and eIF4E2 in human colon cancer HCT116 cells	28
N‐acetylglucosamine sensing in the filamentous soil fungus Trichoderma reesei	28
Redox imbalance and hypoxia‐inducible factors: a multifaceted crosstalk	27
The C‐terminal domain of MinC, a cell division regulation protein, is sufficient to form a copolymer with MinD	27
Bridging the gap between single receptor type activity and whole‐brain dynamics	27
A novel hexameric NADP⁺‐reducing [FeFe] hydrogenase from Moorella thermoacetica	27
FBXL20‐mediated ubiquitination triggers the proteasomal degradation of 4‐1BB	27
Balance between autophagy and cell death is maintained by Polycomb‐mediated regulation during stem cell differentiation	26
Inhibition of epithelial‐to‐mesenchymal transition augments antitumor efficacy of nanotherapeutics in pancreatic ductal adenocarcinoma	26
MLDSR, the transcriptional regulator of the major lipid droplets protein MLDS, is controlled by long‐chain fatty acids and contributes to the lipid‐accumulating phenotype in olea	26
Structural characterization of the thermal unfolding pathway of human VEGFR1 D2 domain	26
In‐solution structure and oligomerization of human histone deacetylase 6 – an integrative approach	26
CD74–ROS1 L2026M mutant enhances autophagy through the MEK/ERK pathway to promote invasion, metastasis and crizotinib resistance in non‐small cell lung cancer cells	26
Hematopoietic PBX‐interacting protein is a novel regulator of mammary epithelial cell differentiation	26
Myosin heavy chain‐perinatal regulates skeletal muscle differentiation, oxidative phenotype and regeneration	25
Nizp1 is a specific NUP98‐NSD1 functional interactor that regulates NUP98‐NSD1‐dependent oncogenic programs	25
Flexible linker modulates the binding affinity of the TP901‐1 CI phage repressor to DNA	25
Issue Information	25
Unexpected expansion of the voltage‐gated proton channel family	25
Tumor immune evasion: insights from CRISPR screens and future directions	25
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Proteasome inhibition alters mitotic progression through the upregulation of centromeric α‐Satellite RNAs	24
Timeless in animal circadian clocks and beyond	24
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Regulation of innate immune responses by cell death‐associated caspases during virus infection	24
Mycobacterium tuberculosis transcriptional regulator Rv1019 is upregulated in hypoxia, and negatively regulates Rv3230c‐Rv3229c operon encoding enzymes in the oleic acid biosynthetic pat	24
Senescence in the ageing skin: a new focus on mTORC1 and the lysosome	23
A liquid culture cancer spheroid model reveals low PI3K/Akt pathway activity and low adhesiveness to the extracellular matrix	23
Hypoxia‐induced increase in sphingomyelin synthase 2 aggravates ischemic skeletal muscle inflammation	23
Championing fundamental discovery research: quality over quantity	23
Calcium signaling as an integrator and decoder of niche factors to control somatic stem cell quiescence and activation	23
Rational design facilitates the improvement of glucose tolerance and catalytic properties of a β‐glucosidase from Acetivibrio thermocellus	23
Rhotekin‐1 is a novel interacting protein and regulator of TRPC6 activity	23

Structural insights into hydrolytic defluorination of difluoroacetate by microbial fluoroacetate dehalogenases	23
Histone degradation by the proteasome regulates chromatin and cellular plasticity	22
Antitumour drugs targeting tau R3 VQIVYK and Cys322 prevent seeding of endogenous tau aggregates by exogenous seeds	22
TRIM27is an autophagy substrate facilitating mitochondria clustering and mitophagy via phosphorylatedTBK1	22
The first structure–function study of GH151 α‐l‐fucosidase uncovers new oligomerization pattern, active site complementation, and selective substrate specificity	22
Molecular characterization of the craniosynostosis‐associated interleukin‐11 receptor variants p.T306_S308dup and p.E364_V368del	22
Infection‐induced inflammation from specific inborn errors of immunity to COVID‐19	22
The flavodiiron protein from Syntrophomonas wolfei has five domains and acts both as an NADH:O₂ or an NADH:H₂O₂ oxidoreductase	22
Words of advice: how to write the story of a patient for a problem‐based learning session in a healthcare education program	21
Mitochondria: great balls of fire	21
	21
Conversion of pyridoxal to pyridoxamine with NH₃ and H₂ on nickel generates a protometabolic nitrogen shuttle under serpentinizing conditions	21
Identification and functional analysis of a new type of Z,E‐mixed prenyl reductase from mycobacteria	21
Probing invadosomes: technologies for the analysis of invadosomes	21
Structure of human phospholipase D3, a single‐strand exonuclease associated with Alzheimer's disease	21
Research highlights	20
Diversity of CysD domains in gel‐forming mucins	20
From fat storage to immune hubs: the emerging role of adipocytes in coordinating the immune response to infection	20
Functions and origins of cardiac fat	20
Spatial and temporal key steps in early‐life intestinal immune system development and education	20
Deregulation of HSF1‐mediated endoplasmic reticulum unfolded protein response promotes cisplatin resistance in lung cancer cells	20
Sphingosine 1‐phosphate signaling axis mediates neuropeptide S‐induced invasive phenotype of endometriotic cells	20
An efficient peptide ligase engineered from a bamboo asparaginyl endopeptidase	20
The ever‐expanding landscape of cancer therapeutic approaches	20
Trypsin‐induced aggregation of transthyretin Valine 30 variants associated with hereditary amyloidosis	20
Sonic Hedgehog signalling in the regulation of barrier tissue homeostasis and inflammation	19
Emerging roles of the Hippo signaling pathway in modulating immune response and inflammation‐driven tissue repair and remodeling	19
Resurrection and characterization of ancestral CYP11A1 enzymes	19
Regulatory phosphorylation event of phosphoglucomutase 1 tunes its activity to regulate glycogen metabolism	19
Fish antifreeze protein origin in sculpins by frameshifting within a duplicated housekeeping gene	19
Structural and functional analysis of two SHMT8 variants associated with soybean cyst nematode resistance	19
Fusarium verticillioidesNAT1 (FDB2) N‐malonyltransferase is structurally, functionally and phylogenetically distinct from its N‐acetyltransferase (NAT	19
Core fucose‐specific Pholiota squarrosa lectin (PhoSL) as a potent broad‐spectrum inhibitor of SARS‐CoV‐2 infection	18
Species barrier as molecular basis for adaptation of synthetic prions with N‐terminally truncated PrP	18
Analysis of ligand binding and resulting conformational changes in pyrophosphatase NUDT9	18
SYVN1‐mediated ubiquitination and degradation of MSH3 promotes the apoptosis of lens epithelial cells	18
Regulation of cardiovascular and cardiac functions by caveolins	18
Molecular characterization of cyanobacterial short‐chain prenyltransferases and discovery of a novel GGPP phosphatase	18
SND1, a novel co‐activator of HIF1α, promotes tumor initiation in PyMT‐induced breast tumor	18
SMAR1 and p53‐regulated lncRNA RP11‐431M3.1 enhances HIF1A translation via miR‐138 in colorectal cancer cells under oxidative stress	17
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Issue Information	17
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Enhancing therapeutic efficacy through degradation of endogenous extracellular matrix in primary breast tumor spheroids	17
NFκB dynamics‐dependent epigenetic changes modulate inflammatory gene expression and induce cellular senescence	17
Structures of BlEst2 from Bacillus licheniformis in its propeptide and mature forms reveal autoinhibitory effects of the C‐terminal domain	17
CBR1 decreases protein carbonyl levels via the ROS/Akt/CREB pathway to extend lifespan in the cotton bollworm, Helicoverpa armigera	17
The FEBS Journal in 2025: in all science, error precedes the truth	17
Obesity, white adipose tissue and cancer	17
USP19 exerts a tumor‐promoting role in diffuse large B cell lymphoma through stabilizing PARK7	17
Identification of a novel inhibitor of SARS‐CoV‐2 main protease: an in silico, biochemical, and cell‐based approach	17
Issue Information	17
The calcium‐sensing receptor alleviates endothelial inflammation in atherosclerosis through regulation of integrin β1‐NLRP3 inflammasome	16
HOIL‐1‐catalysed, ester‐linked ubiquitylation restricts IL‐18 signaling in cytotoxic T cells but promotes TLR signalling in macrophages	16
Metabolite‐derived damage‐associated molecular patterns in immunological diseases	16
Post‐translational modifications of proteins in cardiovascular diseases examined by proteomic approaches	16
Regulation of physiological and pathological condensates by molecular chaperones	16
Structural insights reveal the second base catalyst of isomaltose glucohydrolase	16
Reducing embryonic mtDNA copy number alters epigenetic profile of key hepatic lipolytic genes and causes abnormal lipid accumulation in adult mice	16
A new player in the game: identification of C1ql1 as a novel factor driving OPC differentiation	16
A genome‐wide CRISPR screen identifies USP1 as a novel regulator of the mammalian circadian clock	16
Trypanosoma cruzi heme responsive gene (TcHRG) plays a central role in orchestrating heme uptake in epimastigotes	16
Identification of diverse lipid‐binding modes in the groove of zinc α₂ glycoprotein reveals its functional versatility	15
	15
Deciphering the tight metabolite‐level regulation of glucose‐1‐phosphate adenylyltransferase (GlgC) for glycogen synthesis in cyanobacteria	15
Correction	15
Functional diversity in archaeal Hsp60: a molecular mosaic of Group I and Group II chaperonin	15
The biophysical and compositional properties of human basement membranes	15
Probing heavy metal binding to phycobiliproteins	15
Structural and biophysical characterisation of ubiquitin variants that inhibit the ubiquitin conjugating enzyme Ube2d2	15
Corrigendum	15
Conserved residues Glu37 and Trp229 play an essential role in protein folding of β‐lactamase	15
Transcriptional factor ISL1 regulates palate development by tuning the SHH cascade	15
Genetic and epigenetic dysregulation of innate immune mechanisms in autoinflammatory diseases	15
Unusual photodynamic characteristics of the light‐oxygen‐voltage domain of phototropin linked to terrestrial adaptation of Klebsormidium nitens	15
Corrigendum	15
LRRK2 recruitment, activity, and function in organelles	14
PAR recognition by PARP1 regulates DNA‐dependent activities and independently stimulates catalytic activity of PARP1	14
Sorting nexins: role in the regulation of blood pressure	14
Correction	14
Glycan quality control in and out of the endoplasmic reticulum of mammalian cells	14
Nek4 regulates mitochondrial respiration and morphology	14
Editor Profile: Alexander Wlodawer	14
AgRP neurons: Regulators of feeding, energy expenditure, and behavior	14
Stress‐inducible phosphoprotein 1 (Sti1/Stip1/Hop) sequesters misfolded proteins during stress	14
Ruminococcus gnavus in the gut: driver, contributor, or innocent bystander in steatotic liver disease?	14
NEAT1 repression by MED12 creates chemosensitivity in p53 wild‐type breast cancer cells	14
Current advances in antiviral RNA interference in mammals	14
Reciprocal abrogation of PKM isoforms: contradictory outcomes and differing impact of splicing signal on CRISPR/Cas9 mediates gene editing in keratinocytes	14
Novel insights into the roles of Cdc7 in response to replication stress	14
New roles for desmin in the maintenance of muscle homeostasis	14
Interneuron development and dysfunction	14
Translation initiation factor eIF1A rescues hygromycin B sensitivity caused by deleting the carboxy‐terminal tail in the GPN‐loop GTPase Npa3	14
Caspase‐9 acts as a regulator of necroptotic cell death	14
Proteomic profiling identifies a direct interaction between heat shock transcription factor 2 and the focal adhesion adapter talin‐1	14