OOIR: Observatory of International Research

Papers

(The TQCC of FEBS Journal is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
A guide to the composition and functions of the extracellular matrix	352
Low plasma 25(OH) vitamin D level is associated with increased risk of COVID‐19 infection: an Israeli population‐based study	292
A guide to assessing cellular senescence in vitro and in vivo	270
Rab family of small GTPases: an updated view on their regulation and functions	228
Signaling pathways and defense mechanisms of ferroptosis	195
A Guide to COVID‐19: a global pandemic caused by the novel coronavirus SARS‐CoV‐2	189
A guide to plasma membrane solute carrier proteins	175
A guide to: generation and design of nanobodies	160
New insights into the activities and toxicities of the old anticancer drug doxorubicin	152
Multifunctional intracellular matrix metalloproteinases: implications in disease	150
Targeting cellular senescence with senotherapeutics: senolytics and senomorphics	143
ADP‐ribosyltransferases, an update on function and nomenclature	142
Sumoylation on its 25th anniversary: mechanisms, pathology, and emerging concepts	133
Understanding SARS‐CoV‐2 endocytosis for COVID‐19 drug repurposing	133
Exosomes as mediators of immune regulation and immunotherapy in cancer	109
The structural basis of accelerated host cell entry by SARS‐CoV‐2†	108
Sympathetic activation: a potential link between comorbidities and COVID‐19	97
A guide to the regulation of selective autophagy receptors	92
More than just protein building blocks: how amino acids and related metabolic pathways fuel macrophage polarization	88
Cellular senescence: all roads lead to mitochondria	83
A guide to the Michaelis–Menten equation: steady state and beyond	82
Hallmarks of the aging T‐cell system	75
The role of PARP1 in neurodegenerative diseases and aging	72
The mitochondrial permeability transition: Recent progress and open questions	71
Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise	71

The blood–retina barrier in health and disease	68
AMPK, metabolism, and vascular function	67
Indoleamine 2,3‐dioxygenase 1 (IDO1): an up‐to‐date overview of an eclectic immunoregulatory enzyme	65
Proteomic characteristics of bronchoalveolar lavage fluid in critical COVID‐19 patients	64
Global functions of O‐glycosylation: promises and challenges in O‐glycobiology	64
Transposable element regulation and expression in cancer	62
Nrf2 and oxidative stress in liver ischemia/reperfusion injury	62
A guide to studying protein aggregation	60
Immunogenicity and humanization of single‐domain antibodies	60
The role of structural dynamics in GPCR‐mediated signaling	59
Microbiota modulation as preventative and therapeutic approach in Alzheimer’s disease	58
The multifaceted role of TRAIL signaling in cancer and immunity	58
Human transfer RNA modopathies: diseases caused by aberrations in transfer RNA modifications	57
Revisiting sORFs: overcoming challenges to identify and characterize functional microproteins	57
Epithelial‐to‐mesenchymal‐like transition events in melanoma	56
Protein S‐Palmitoylation: advances and challenges in studying a therapeutically important lipid modification	54
Targeting dormant tumor cells to prevent cancer recurrence	53
The more the merrier: effects of macromolecular crowding on the structure and dynamics of biological membranes	53
Tumor‐associated macrophages in immunotherapy	53
A guide to membrane protein X‐ray crystallography	52
New roles for desmin in the maintenance of muscle homeostasis	52
Understanding the role of cysteine in ferroptosis: progress & paradoxes	51
LD‐transpeptidases: the great unknown among the peptidoglycan cross‐linkers	51
Oxygen‐sensing mechanisms in cells	51
Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage‐gated calcium channels and NADPH oxidase	51
Emerging roles of ferroptosis in the tumor immune landscape: from danger signals to anti‐tumor immunity	50
AgRP neurons: Regulators of feeding, energy expenditure, and behavior	50
Alternative systems for misfolded protein clearance: life beyond the proteasome	50
Nuclear speckles: dynamic hubs of gene expression regulation	48
Ferroptosis: regulation by competition between NRF2 and BACH1 and propagation of the death signal	48
Insights into the H₂O₂‐driven catalytic mechanism of fungal lytic polysaccharide monooxygenases	47
Long‐term plasticity in the hippocampus: maintaining within and ‘tagging’ between synapses	46
Signaling pathways regulating the fate of fibro/adipogenic progenitors (FAPs) in skeletal muscle regeneration and disease	46
New targets for drug design: importance of nsp14/nsp10 complex formation for the 3’‐5’ exoribonucleolytic activity on SARS‐CoV‐2	46
Nicotine and the nicotinic cholinergic system in COVID‐19	45
Molecular mechanisms regulating Proteinase‐Activated Receptors (PARs)	45
Host PDZ‐containing proteins targeted by SARS‐CoV‐2	45
LRRK2 recruitment, activity, and function in organelles	45
Elastic fibers: formation, function, and fate during aging and disease	45
Structural and biochemical properties of L‐asparaginase	45
Structural insights into the multiple binding modes of Dimethyl Fumarate (DMF) and its analogs to the Kelch domain of Keap1	44
Plant protein phosphatases: What do we know about their mechanism of action?	44
Progress and outlook in studying the substrate specificities of PARPs and related enzymes	43
Interferon‐γ induces retinal pigment epithelial cell Ferroptosis by a JAK1‐2/STAT1/SLC7A11 signaling pathway in Age‐related Macular Degeneration	43
COVID‐19, cilia, and smell	43
Clinical advances in targeting epigenetics for cancer therapy	43
Aberrant phase separation and cancer	43
The role of cellular senescence and SASP in tumour microenvironment	42
Pediatric high‐grade glioma: moving toward subtype‐specific multimodal therapy	42
The mitochondrial coenzyme Q junction and complex III: biochemistry and pathophysiology	42

Enzymes, pseudoenzymes, and moonlighting proteins: diversity of function in protein superfamilies	41
Recent advances on smart glycoconjugate vaccines in infections and cancer	41
Human guanylate binding proteins: nanomachines orchestrating host defense	41
Autophagy at the interface of endothelial cell homeostasis and vascular disease	41
Durotaxis: the mechanical control of directed cell migration	41
Venn diagram analysis overestimates the extent of circadian rhythm reprogramming	40
The intricate balance between microRNA‐induced mRNA decay and translational repression	40
Proteasome interaction with ubiquitinated substrates: from mechanisms to therapies	40
Matrix stiffness‐mediated effects on macrophages polarization and their LOXL2 expression	40
Endocrine regulation of immunity in insects	40
Roles of neutrophil granule proteins in orchestrating inflammation and immunity	39
Past, present and future of zebrafish in epilepsy research	39
FOXOs: masters of the equilibrium	39
Toward unzipping the ZIP metal transporters: structure, evolution, and implications on drug discovery against cancer	38
Signaling and function of cardiac autonomic nervous system receptors: Insights from the GPCR signalling universe	38
Migrasome biogenesis and functions	38
AMPK in the brain: its roles in glucose and neural metabolism	38
Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis	38
Energy metabolism in brown adipose tissue	38
The state of CD44 activation in cancer progression and therapeutic targeting	38
NET formation – mechanisms and how they relate to other cell death pathways	37
How does fascin promote cancer metastasis?	37
Analytical methods for the investigation of enzyme‐catalyzed degradation of polyethylene terephthalate	37
Allosteric coupling and biased agonism in G protein‐coupled receptors	37
New insights into the organization and regulation of the apical polarity network in mammalian epithelial cells	37
The largely unexplored biology of small proteins in pro‐ and eukaryotes	37
Silibinin induces metabolic crisis in triple‐negative breast cancer cells by modulating EGFR‐MYC‐TXNIP axis: potential therapeutic implications	36
Regulation of redox signaling in HIF‐1‐dependent tumor angiogenesis	36
Liver macrophages and inflammation in physiology and physiopathology of non‐alcoholic fatty liver disease	36
The multifaceted role of cell cycle regulators in the coordination of growth and metabolism	36
Home, sweet home: how mucus accommodates our microbiota	36
A tale of two proteins: PACT and PKR and their roles in inflammation	35
Apoptosis – Fueling the oncogenic fire	35
Metabolic requirements of pulmonary fibrosis: role of fibroblast metabolism	35
Ligand‐centered assessment of SARS‐CoV‐2 drug target models in the Protein Data Bank	35
The gate to metastasis: key players in cancer cell intravasation	35
Collagen VI as a driver and disease biomarker in human fibrosis	35
Role of the Hippo pathway and mechanisms for controlling cellular localization of YAP/TAZ	34
Calcium signaling in cancer progression and therapy	34
The use of aspirin for primary prevention of cardiovascular disease is associated with a lower likelihood of COVID‐19 infection	34
The characteristics and roles of β‐TrCP1/2 in carcinogenesis	34
Protein cysteine palmitoylation in immunity and inflammation	33
Mechanisms of vascular damage by systemic dissemination of the oral pathogen Porphyromonas gingivalis	33
Diverse and pivotal roles of neddylation in metabolism and immunity	33
Serum response factor‐cofactor interactions and their implications in disease	33
Noncoding RNAs in vascular smooth muscle cell function and neointimal hyperplasia	32
Cancers associated with human gammaherpesviruses	32
COVID‐19 breakthroughs: separating fact from fiction	32
Enzyme nomenclature and classification: the state of the art	32
Targeting the molecular & cellular pillars of human aging with exercise	32
Instructive roles of astrocytes in hippocampal synaptic plasticity: neuronal activity‐dependent regulatory mechanisms	32
Long non coding RNA SLC26A4‐AS1 exerts antiangiogenic effects in human glioma by upregulating NPTX1 via NFKB1 transcriptional factor	31
Spage2vec: Unsupervised representation of localized spatial gene expression signatures	31
Tryptophan and its metabolites in normal physiology and cancer etiology	31
Viruses join the circular RNA world	30
Novel FMRP interaction networks linked to cellular stress	30
A guide to changing paradigms of glucocorticoid receptor function—a model system for genome regulation and physiology	30
A guide to genetically encoded tools for the study of H₂O₂	30
Iron and liver cancer: an inseparable connection	30
Role of post‐translational modifications in the acquisition of drug resistance in Mycobacterium tuberculosis	30
Cholesterol metabolism pathways – are the intermediates more important than the products?	29
Membrane protein biogenesis at the ER: the highways and byways	29
Overview of antiviral drug candidates targeting coronaviral 3C‐like main proteases	29
EHMT1/EHMT2 in EMT, cancer stemness and drug resistance: emerging evidence and mechanisms	29
The co‐existence of cold activity and thermal stability in an Antarctic GH42 β‐galactosidase relies on its hexameric quaternary arrangement	29
Alveolar epithelial cell‐derived Sonic hedgehog promotes pulmonary fibrosis through OPN‐dependent alternative macrophage activation	29
The specification and function of enteroendocrine cells in Drosophila and mammals: a comparative review	29
Hsa_circ_0000515 is a novel circular RNA implicated in the development of breast cancer through its regulation of the microRNA‐296‐5p/CXCL10 axis	28
Words of Advice: teaching enzyme kinetics	28
The lysosomal membrane—export of metabolites and beyond	28
The discovery of dystrophin, the protein product of the Duchenne muscular dystrophy gene	28
Oncogenic dysregulation of pre‐mRNA processing by protein kinases: challenges and therapeutic opportunities	28
Beyond energy storage: roles of glycogen metabolism in health and disease	28
The colorful versatility of adipocytes: white‐to‐brown transdifferentiation and its therapeutic potential in humans	28
Insights into muscle stem cell dynamics during postnatal development	28
TRPV4 integrates matrix mechanosensing with Ca²⁺ signaling to regulate extracellular matrix remodeling	28
Recent progress of bacterial FtsZ inhibitors with a focus on peptides	28
Metabolic roles of G protein‐coupled receptor signaling in obesity and type 2 diabetes	27
The two faces of cyanide: an environmental toxin and a potential novel mammalian gasotransmitter	27
Model membrane systems to reconstitute immune cell signaling	27

Druggable genome and precision medicine in cancer: current challenges	27
From stretch to deflection: the importance of context in the activation of mammalian, mechanically activated ion channels	27
Pharmacological inhibition and knockdown of O‐GlcNAcase reduces cellular internalization of α‐synuclein preformed fibrils	27
The eIF2α kinase HRI in innate immunity, proteostasis, and mitochondrial stress	27
Using unnatural amino acids to selectively label proteins for cellular imaging: a cell biologist viewpoint	27
Molecular and spatial mechanisms governing STING signalling	27
CRY1‐CBS binding regulates circadian clock function and metabolism	27
Structure and function of p62/SQSTM1 in the emerging framework of phase separation	27
Supply and demand—heme synthesis, salvage and utilization by Apicomplexa	27
Autophagy in the retinal pigment epithelium: a new vision and future challenges	26
Second sialic acid‐binding site of influenza A virus neuraminidase: binding receptors for efficient release	26
Neuroimmune interaction in seizures and epilepsy: focusing on monocyte infiltration	26
Interpreting the role of the striatum during multiple phases of motor learning	26
Tools to study and target the Siglec–sialic acid axis in cancer	26
Autophagy is responsible for the accumulation of proteogenic dipeptides in response to heat stress in Arabidopsis thaliana	26
Autophagy and tumorigenesis	26
Mitochondrial matrix proteases: quality control and beyond	26
The duality of PRDM proteins: epigenetic and structural perspectives	25
Targeting evolution to inhibit antibiotic resistance	25
The role of goblet cells in viral pathogenesis	25
Molecular events underlying the cell‐to‐cell transmission of α‐synuclein	25
CCCP‐induced mitochondrial dysfunction – characterization and analysis of integrated stress response to cellular signaling and homeostasis	25
SARS‐CoV‐2 variants preferentially emerge at intrinsically disordered protein sites helping immune evasion	25
Cholesterol dyshomeostasis in amyotrophic lateral sclerosis: cause, consequence, or epiphenomenon?	25
Microalgal protein AstaP is a potent carotenoid solubilizer and delivery module with a broad carotenoid binding repertoire	25
The heparan sulfate proteoglycan syndecan‐1 regulates colon cancer stem cell function via a focal adhesion kinase—Wnt signaling axis	25
Bottom‐up reconstitution of focal adhesion complexes	25
In vivo glial trans‐differentiation for neuronal replacement and functional recovery in central nervous system	24
Arc self‐association and formation of virus‐like capsids are mediated by an N‐terminal helical coil motif	24
Imaging the future: the emerging era of single‐cell spatial proteomics	24
Lipids uniquely alter the secondary structure and toxicity of amyloid beta 1–42 aggregates	24
The dead phosphatases society: a review of the emerging roles of pseudophosphatases	24
A double‐edged sword: reactive oxygen species (ROS) during the rice blast fungus and host interaction	24
Signaling at the endosome: cryo‐EM structure of a GPCR–G protein–beta‐arrestin megacomplex	24
Allosteric communication regulates ligand‐specific GPCR activity	24
Specialized pro‐resolving mediators: biosynthesis and biological role in bacterial infections	24
Driving CARs with alternative navigation tools – the potential of engineered binding scaffolds	24
Mitochondrial fusion and fission are required for proper mitochondrial function and cell proliferation in fission yeast	23
Cholesterol‐containing lipid nanodiscs promote an α‐synuclein binding mode that accelerates oligomerization	23
Regulatory roles of circRNAs in adipogenesis and lipid metabolism: emerging insights into lipid‐related diseases	23
Exosomal and vesicle‐free tau seeds—propagation and convergence in endolysosomal permeabilization	23
Protein structural and mechanistic basis of progeroid laminopathies	23
Voltage‐gated calcium channel nanodomains: molecular composition and function	23
Emerging glyco‐based strategies to steer immune responses	23
HDAC11: a multifaceted histone deacetylase with proficient fatty deacylase activity and its roles in physiological processes	23
Src family kinases (SFKs): critical regulators of microglial homeostatic functions and neurodegeneration in Parkinson's and Alzheimer's diseases	23
A glaucoma‐ and ALS‐associated mutant of OPTN induces neuronal cell death dependent on Tbk1 activity, autophagy and ER stress	23
Function of pH‐dependent transcription factor PacC in regulating development, pathogenicity, and mycotoxin biosynthesis of phytopathogenic fungi	23
Tumor markers as an entry for SARS‐CoV‐2 infection?	23
Roles of dopamine and glutamate co‐release in the nucleus accumbens in mediating the actions of drugs of abuse	23
A guide to time‐resolved structural analysis of light‐activated proteins	23
Stress granules: regulators or by‐products?	23
Phenotypic heterogeneity, stability and plasticity in tumor‐promoting carcinoma‐associated fibroblasts	23
Vitamin D to prevent COVID‐19: recommendations for the design of clinical trials	22
Targeting DNA damage response pathways to activate the STING innate immune signaling pathway in human cancer cells	22
Protease‐sensitive regions in amyloid light chains: what a common pattern of fragmentation across organs suggests about aggregation	22
Modeling CSF‐1 receptor deficiency diseases – how close are we?	22
Targeting ER stress in the hepatic tumor microenvironment	22
A recent update on small‐molecule kinase inhibitors for targeted cancer therapy and their therapeutic insights from mass spectrometry‐based proteomic analysis	22
p53 in senescence – it's a marathon, not a sprint	22
Involvement of Wnt signaling in primary cilia assembly and disassembly	22
Angiotensin‐converting enzyme open for business: structural insights into the subdomain dynamics	22
HDAC11 is a novel regulator of fatty acid oxidative metabolism in skeletal muscle	22
Revisiting preeclampsia: a metabolic disorder of the placenta	22
Hepsin: a multifunctional transmembrane serine protease in pathobiology	22
Chloroplast protein import machinery and quality control	21
Oxygen regulation of TET enzymes	21
Astrocyte–synapse interactions and cell adhesion molecules	21
Discovery of linear ubiquitination, a crucial regulator for immune signaling and cell death	21
Cancer cell metabolism connects epigenetic modifications to transcriptional regulation	21
Goodnight, astrocyte: waking up to astroglial mechanisms in sleep	21
Genome‐wide interaction screen for Mycobacterium tuberculosis ClpCP protease reveals toxin–antitoxin systems as a major substrate class	21
Marine cyanobacteria tune energy transfer efficiency in their light‐harvesting antennae by modifying pigment coupling	21
Microtubule‐associated proteins and emerging links to primary cilium structure, assembly, maintenance, and disassembly	21
Par‐3 family proteins in cell polarity & adhesion	21
The role of RNA‐binding proteins in mediating adaptive responses in Gram‐positive bacteria	21
Matrix metalloproteinase‐13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha‐1 antitrypsin: Implications for osteoarthritis	21
Molecular basis for the recognition of steroidogenic acute regulatory protein by the 14‐3‐3 protein family	20
Understanding MCL1: from cellular function and regulation to pharmacological inhibition	20
Targeting tumour necrosis factor to ameliorate viral pneumonia	20
Pathophysiology of type 2 diabetes and the impact of altered metabolic interorgan crosstalk	20
Cannabinoid control of hippocampal functions: the where matters	20
Enzymology of the pathway for ATP production by arginine breakdown	20
Roles of cell fusion between mesenchymal stromal/stem cells and malignant cells in tumor growth and metastasis	20
Preferential redox regulation of cysteine‐based protein tyrosine phosphatases: structural and biochemical diversity	20
Mass spectrometry‐based characterization of histones in clinical samples: applications, progress, and challenges	20
The ups and downs of growth hormone secretagogue receptor signaling	19
Mammalian circadian networks mediated by the suprachiasmatic nucleus	19
Revisiting the steps of Salmonella gut infection with a focus on antagonistic interbacterial interactions	19
The function of apolipoproteins L (APOLs): relevance for kidney disease, neurotransmission disorders, cancer and viral infection	19
A guide to adhesion GPCR research	19
Balancing life and death: BCL‐2 family members at diverse ER–mitochondrial contact sites	19
Understanding how kinesin motor proteins regulate postsynaptic function in neuron	19
Interneuron development and dysfunction	19
Full circle: a brief history of cohesin and the regulation of gene expression	19