FEBS Journal

Article	Citations
	106
Table of Contents	91
Issue Information	86
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The FEBS Journal in 2025: in all science, error precedes the truth	79
A novel allosteric site employs a conserved inhibition mechanism in human kidney‐type glutaminase	78
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Calcium‐induced structural transitions are central to the folding, function, and processing of serratiopeptidase zymogen into mature form	68
On the track of intramembrane clippers: the SPPL2a/b proteases caught in the act in animal models	67
Exploring the roles of conserved context‐dependent cis‐regulatory elements ( cdCREs ) in multicellularity, human health and disease	60
CARPs regulate STUB1 and its pathogenic mutants aggregation kinetics by mono‐ubiquitination	58
The biophysical and compositional properties of human basement membranes	55
Structural and functional characterization of the newly identified Photorhabdus laumondii tumor necrosis factor‐like lectin	54
The interaction network of the proteasome assembly chaperone PSMD9 regulates proteostasis	52
Nizp1 is a specific NUP98 ‐ NSD1 functional interactor that regulates NUP	47
Inhibition of epithelial‐to‐mesenchymal transition augments antitumor efficacy of nanotherapeutics in pancreatic ductal adenocarcinoma	46
A novel gyrase inhibitor from toxin–antitoxin system expressed by Staphylococcus aureus	46
Lysine demethylase 4A : from chromatin to centrosomes	44
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Pyruvate dehydrogenase phosphatase 1 (PDP1) stimulates HIF activity by supporting histone acetylation under hypoxia	43
SMAR1 and p53‐regulated lncRNA RP11 ‐ 431M3 .1 enhances	43
RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF ‐β signaling	41
Full activation of thermogenesis in brown adipocytes requires Basigin action	41
Sialic acid biophore directed design of enhanced affinity HN protein from Newcastle disease virus	41
Toward understanding the catalytic mechanism for two classes of bacterial phospholipid N ‐methyltransferases	40

Regulation of cardiovascular and cardiac functions by caveolins	40
Prebiotic aqueous reactions catalyzed by native nickel without hydrogen	38
MLDSR, the transcriptional regulator of the major lipid droplets protein MLDS, is controlled by long‐chain fatty acids and contributes to the lipid‐accumulating phenotype in olea	38
Tissue integrity at the root of Metazoa – transcriptional landscape of whole‐body regeneration in sponges	37
KU80 suppresses endonuclease G activity to preserve genomic integrity	36
Extracellular matrix cross‐talk with proteases: A master switch for remodeling and cell regulation in health and disease	36
Obesity, white adipose tissue and cancer	36
A novel hexameric NADP+‐reducing [FeFe] hydrogenase from Moorella thermoacetica	35
Impact of N‐linked glycans on the dual short fibulin/ LTBP ‐4 axes regulating elastogenesis	35
The importin‐alpha superfamily engages in ethylene signaling by shuttling ETHYLENE INSENSITIVE 2 from the endoplasmic reticulum to the nucleus	34
A genome‐wide CRISPR screen identifies USP1 as a novel regulator of the mammalian circadian clock	33
Site 1 protease aggravates acute kidney injury by promoting tubular epithelial cell ferroptosis through SIRT3‐SOD2‐mtROS signaling	33
Metabolite‐derived damage‐associated molecular patterns in immunological diseases	33
Mechanism for synthesis of isomaltooligosaccharides from maltooligosaccharides by GH 15 α‐glucan 4(6)‐α‐glucosyltransferase	33
Succinate receptor 1 signaling mutually depends on subcellular localization and cellular metabolism	33
Allosteric activation of PARP2 self‐ PARylation by SUMO	32
Biogenesis of TNF ‐α‐insights into proteostasis and inflammation	32
Detection of endogenous LINE ‐1 ORF2p and its potent reverse transcriptase activity in the	32
The calcium‐sensing receptor alleviates endothelial inflammation in atherosclerosis through regulation of integrin β1‐NLRP3 inflammasome	31
Deciphering the tight metabolite‐level regulation of glucose‐1‐phosphate adenylyltransferase ( GlgC ) for glycogen synthesis in cyanobacteria	30
A guide to laser microdissection‐based proteomics	30
The effects of two Leu‐to‐Pro substitutions, L57P and L43P , on structural and functional properti	30
Table of Contents	29
The role of the gut microbiome in disorders of gut–brain interaction	29
Intercellular mitochondrial transfer contributes to microenvironmental redirection of cancer cell fate	29
Protein succinylome analysis identifies citrate synthase as a central regulator of osteoclast metabolic activity	29
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Table of Contents	27
New links for meprin β within the protease web	26
Multisubstrate‐based system: a kinetic mechanism study of catechol‐ O ‐methyltransferase	26
Table of Contents	26
Take a breath: oxygen sensing of epidermal differentiation	26
Table of Contents	26
Modifying inhibitor specificity for homologous enzymes by machine learning	25
Alternative substrate‐assisted hydrolysis pathways of posttransfer editing by prokaryotic leucyl‐ tRNA synthetase	25
New insights into macrophage heterogeneity in renal injury and repair	25
Issue Information	24
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What's in a name: the multifaceted function of DNA‐ and RNA‐binding proteins in T cell responses	24
The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes	23
The CGA codon decoding through tRNA Arg	23
Substrate preference, RNA binding and active site versatility of Stenotrophomonas maltophilia nuclease	23
Salmonella ‐driven intestinal edema in mice is characterized by tensed fibronectin fibers	23
The SARS ‐ CoV ‐2 spike protein interacts with HAX1	23
Plasmodium mitochondrial exodeoxyribonucleases, Exo mit1 and Exo mit2 ,	23
Anchoring of hyaluronan glycocalyx to CD44 reduces sensitivity of HER2‐positive gastric cancer cells to trastuzumab	23
Issue Information	23
Biochemical and structural characterization of chlorite dismutase enzyme from Pseudomonas aeruginosa	23
Multifaceted multivalency with a hub protein	23

AXIN2 is a non‐redundant regulator of AXIN1 stability and β‐catenin in colorectal cancer cells	23
Analysis of mutually exclusive expression in cancer cells identifies a previously unknown intergenic regulatory paradigm	22
Redox environment modulates aggregation of ataxin‐3 in vitro — Implications for drug screening of cysteine‐rich proteins	22
Correction to “Structural determinants of cold activity and glucose tolerance of a family 1 glycoside hydrolase (GH1) from Antarctic Marinomonas sp. ef1”	22
Structural and functional dissection of the WH2 / DAD motif of INF2	22
Glow‐type conversion and characterization of a minimal luciferase via mutational analyses	22
Characterization of multiple lysophosphatidic acid acyltransferases in the plant pathogen Xanthomonas campestris	21
Ionizing radiation inhibits zebrafish embryo hatching through induction of tissue inhibitors of metalloproteinases ( TIMP s) expression	21
RAGE induces physiological activation of NADPH oxidase in neurons and astrocytes and neuroprotection	21
Lock, relax, load, and shoot: a molecular perspective on Nedd4 regulation	21
FAM237A , rather than peptide PEN and proCCK56 ‐63, binds to and ac	21
Synthetic cannabinoid receptor agonists are monoamine oxidase‐A selective inhibitors	20
Mlg1, a yeast acyltransferase located in ER membranes associated with mitochondria (MAMs), is involved in de novo synthesis and remodelling of phospholipids	20
The role of lysosomal membrane proteins in autophagy and related diseases	20
Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH si	20
Redirecting TRIM21 with TRIMTACs for the targeted degradation of multimeric proteins	20
Understanding how enzymes work: the journey to ensemble–function studies	20
A guide to building the matrisome interactome: from computational predictions to experimental validation	20
A guide to ferroptosis, the biological rust of cellular membranes	20
Roles and applications of autophagy in guarding against environmental stress and DNA damage in Saccharomyces cerevisiae	20
Navigating centriolar satellites: the role of PCM1 in cellular and organismal processes	20
Proteolytic cleavage of the TGFβ co‐receptor CD109 changes its conformation, resulting in protease inhibition via activation of its thiol ester, and dissociation from the cell me	20
Fibrillation of α‐synuclein triggered by bacterial endotoxin and lipid vesicles is modulated by N‐terminal acetylation and familial Parkinson's disease mutations	20
Words of advice: teaching macromolecular crystallography	19
A major conformational change of N‐terminal helices of Bacillus thuringiensis Cry1Ab insecticidal protein is necessary for	19
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Issue Information	19
Table of Contents	19
CDK14 is a critical regulator of haematopoietic stem and progenitor cell maintenance and post‐transplantation proliferation	18
Functional role of lncRNAs in gastrointestinal malignancies: the peculiar case of small nucleolar RNA host gene family	18
Group A Streptococcus interacts with glycosaminoglycans via M proteins to modulate bacterial adherence in vitro	18
LRP1 is the cell‐surface endocytosis receptor for vaspin in adipocytes	18
A novel tdTomato transgenic mouse model to visualize FAP‐positive cancer‐associated fibroblasts	18
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Single‐cell atlas of B cell heterogeneity in lacrimal IgG4 ‐related disorders: Unraveling the transition from inflammatory exhaustion to clonal malig	18
Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and t	18
The interaction between NPMc + and Orai1 induces abnormal calcium influx to facilitate leukemogenesis	18
Issue Information	18
Rafoxanide, a salicylanilide anthelmintic, interacts with human plasma protein transthyretin	17
Proline‐directed yeast and human MAP kinases phosphorylate the Dot1p/ DOT1L histone	17
Research highlights	17
Biogenesis of fibrils requires C‐mannosylation of PMEL	17
Structural and functional insights into the flexible β‐hairpin of glycerol dehydrogenase	17
A new metabolic path in type 3 rickets	17
ZBTB7A regulates primed‐to‐naïve transition of pluripotent stem cells via recognition of the PNT‐associated sequence by zinc fingers 1–2 and recognition of γ‐globin −200 gene element by zinc fingers 1	17
The deubiquitinating enzyme USP 8 promotes tyrosine kinase inhibitors resistance in chronic myeloid leukemia by stabilizing	17
Ser38‐His93‐Asn91 triad confers resistance of JFH1 HCV NS5A‐Y93H variant to NS5A inhibitors	17
Further diversity in the origins of fish antifreeze proteins	17
Ageing versus developmental silencing: Answers from the epigenome	17
11‐Cl‐BBQ , a select modulator of AhR ‐regulated transcription, suppresses lung cancer cell growth via activation of p	17
Structural analysis of the peptidoglycan DL‐endopeptidase CwlO complexed with its inhibitory protein IseA	17
Biophysical investigation of the molecular interaction between minichromosome maintenance protein 6 and Bloom syndrome helicase	17
GDH1 exacerbates renal fibrosis by inhibiting the transcriptional activity of peroxisome proliferator‐activated receptor gamma	17
Biostimulants in plant brassinosteroid hormone receptor BRI1 activation—a new system to evaluate activation capacity	17
Defects of the spliceosomal gene SNRPB affect osteo‐ and chondro‐differentiation	16
Protein tandem repeats that produce frameshifts can generate new structural states and functions	16
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The sorting nexin Snx21 promotes flotillin‐mediated endocytosis	16
PEMT ‐mediated phospholipid imbalance promotes age‐associated metabolic dysfunction‐associated steatotic liver disease progression	16
Identification and structural characterization of a novel acetyl xylan esterase from Aspergillus oryzae	16
Interactions of the maternal microbiome with diet, stress, and infection influence fetal development	16
Augmenter of liver regeneration (ALR) can regulate iron homeostasis through the INOS/NO/SLC39A14 pathway to reduce ferroptosis in acute kidney injury	16
Surface loops may provide additional function necessary for enzyme‐to‐pseudoenzyme transition in the fungal metallocarboxypeptidase family	16
Harnessing S. cerevisiae to advance the engineering of pentatricopeptide repeat proteins	16
Identification of a structural mechanism for prediction and discrimination of substrates for multifunctional GH5 cellulases/hemicellulases	16
Anti‐cancer drugs targeting the NADH ‐binding site of VDAC rewire channel electrophysiology and pa	16
Physical and functional interactions between LDLR family members and CXCR4 in breast cancer	16
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The environmental impact of extracellular matrix preparation	15
Is it possible to measure good science?	15
Understanding the catalytic mechanism of the triazine hydrolase from Arthrobacter aurescens TC1	15
Characterisation of an unusual cysteine pair in the Rieske carnitine monooxygenase CntA catalytic site	15
ALOX15 mediates thrombin‐induced myristoylation, trafficking, and interaction of protease‐activated receptors, leading to platelet activation and hemostasis	15
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Structural and interaction analysis of human lipocalin‐type prostaglandin D synthase with the poorly water‐soluble drug NBQX	15
EHD4 and ASAP2 are critical negative regulators of the claudin‐5‐based endothelial barrier	15
Less is better: various means to reduce protein load in the endoplasmic reticulum	15
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Corrigendum to ‘ Cryo‐EM structure of MsbA in saposin‐lipid nanoparticles (Salipro) provides insig	15

Derivatives of MOPS : promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition	15
The emerging role of PKM in keratinocyte homeostasis and pathophysiology	15
Structure–activity analysis of imino‐pyrimidinone‐fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors	14
A year in the molecular life sciences: 2024 highlights	14
Investigating the molecular mechanisms underlying the anti‐ CRISPR function of AcrIIA13b protein	14
Insights into the catalytic mechanism of formate dehydrogenases from different microbial sources	14
Gal‐1 promotes lung cancer cell survival by enhancing PARP1 / H1 .2 interaction to promote	14
Teleost‐specific ictacalcins exhibit similar structural organization, cation‐dependent activation, and transcriptional regulation as human S100 prote	14
Crystal structure and biophysical characterisation of the enterococcal foldase PpiC , a cross‐opsonic antigen against gram‐positive nosocomial pathog	14
Rational engineering of AA5_2 copper radical oxidases to probe the molecular determinants governing their substrate selectivity	14
Uncovering a previously unknown function of polyphosphate in polyadenylated RNA ‐induced amyloidogenesis of Hfq	14
Maize CDKA2 ;1a and CDKB1 ;1 kinases have different requirements for their activation and particip	14
The m6A demethylase FTO promotes C/ EBPβ ‐	14
Limited roles of the miR ‐17‐92 cluster in the regulation of T‐cell apoptosis	14
Phosphatidic acid induces cytoskeletal rearrangements through the Src‐ FAK ‐ R ho	14
Conditional deletion of the multiple sclerosis susceptibility gene ATXN1 identifies cell‐autonomou	14
Tudor staphylococcal nuclease (Tudor‐ SN ) regulates activation of quiescent hepatic stellate cells	14
Structural insights into α‐(1→6)‐linkage preference of GH 97 glucodextranase from Flavobacterium johnsoniae	13
The small molecule ZPD ‐2 inhibits the aggregation and seeded polymerisation of C‐terminally truncated α‐Synuclein	13
Metal ion activation and DNA recognition by the Deinococcus radiodurans manganese sensor	13
A comprehensive overview of yeast libraries and their role in advancing cell biology	13
Nemo‐like kinase blocks myeloid differentiation by targeting tumor suppressor C/EBPα in AML	13
A chemo‐enzymatic colorimetric cascade for detecting ethylene glycol contamination	13
Issue Information	13
Dual‐Cys bacteriophytochromes: intermediates in cyanobacterial phytochrome evolution?	13
Mechanism of cyanobacterial ferredoxin‐dependent flavin thioredoxin reductase reveals thiolate‐ FAD charge transfer and catalytic asymmetry in a homo	13
Lysophospholipid acyltransferase‐mediated formation of saturated glycerophospholipids maintained cell membrane integrity for hypoxic adaptation	13
Interleukin‐1 family cytokines at the crossroads of microbiome regulation in barrier health and disease	13
Evidence for corrin biosynthesis in the last universal common ancestor	13
ER ‐localized translational control as a nexus for proteostasis	13
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The antihypertensive agent ACT ‐132577 alleviates cuproptosis and pressure‐overload‐induced vascular remodelling by modulation of the NEDD4‐LCTR1‐cop	13
Issue Information	13
Neutrophil extracellular traps boost laser‐induced mouse choroidal neovascularization through the activation of the choroidal endothelial cell TLR4/HIF‐1α pathway	13
Mitochondrial dysfunction and cisplatin sensitivity in gastric cancer: GDF15 as a master player	13
The c‐di‐ AMP ‐binding protein CbpB modulates the level of ppGpp	12
Direct capture, inhibition and crystal structure of HsaD (Rv3569c) from M. tuberculosis	12
Metalloprotease‐mediated cleavage of CD95 ligand	12
Deciphering the properties and reaction mechanism of anhydromevalonate phosphate decarboxylase, a prenylated flavin mononucleotide‐dependent enzyme in the archaeal mevalonate pathway	12
PGE2 pathway mediates oxidative stress‐induced ferroptosis in renal tubular epithelial cells	12
Pannexin 1 crosstalk with the Hippo pathway in malignant melanoma	12
Table of Contents	12
Current perspectives on KMT2A fusion proteins and menin inhibition in paediatric acute myeloid leukaemia	12
Table of Contents	12
Circadian disruption elicits sex‐specific gut microbiota, endocannabinoidome, and lipid mediator responses	12
Rewarding excellence: the 2024 FEBS Journal Richard Perham prize	12
Mutant p53 affects the mitochondrial proteome, promoting mitochondrial fragmentation and OXPHOS in pancreatic ductal adenocarcinoma cells	12
PU .1 and TGF ‐β signaling activate the cell‐surface expression of CD103	12
Gut microbiota in multiple sclerosis and animal models	12
Structural dynamics of the N‐terminal SH2 domain of PI3K in its free and	12
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Issue Information	12
Effects of senescence on the tumour microenvironment and response to therapy	12
Mitochondrial dysfunction decreases cisplatin sensitivity in gastric cancer cells through upregulation of integrated stress response and mitokine GDF15	12
Cell wall‐resident proteins with internal repeats ( PIR s) show an inverted architecture in Neurospora crassa	12
A DNA mimic jams the Cas9 scissors	12
Structural and functional dissection of human neurolysin through alanine‐scanning mutagenesis	12
Electrostatic potential as a reactivity scoring function in computer‐assisted enzyme engineering	12
Context‐dependent roles of cellular senescence in normal, aged, and disease states	12
Multi‐omics characterization of synthetic lethality‐related molecular features: implications for SL‐based therapeutic target screening	12
Issue Information	12
Table of Contents	12
Structural characterization of endogenous microprotein EMBOW reveals an alternative MRT motif for	12
Molecular basis of domain‐specific angiotensin I‐converting enzyme inhibition by the antihypertensive drugs enalaprilat, ramiprilat, trandolaprilat, quinaprilat and perindoprilat	12
Arsenite methyltransferase 3 is required for mitochondrial function and hepatic lipid metabolism	11
Oxidative stress‐induced YAP1 expression is regulated by NCE102, CDA2, and BCS1	11
Lipid regulation of adenylyl cyclase Rv1625c from Mycobacterium tuberculosis by its membrane‐domain receptor	11
Role of human RNase 7 in neuronal and glial cell models: moving towards an unexpected new functional link	11
Autophagy of the ER: the secretome finds the lysosome	11
The role of compartmentalized β‐AR/cAMP signaling in the regulation of lipolysis in white and brown adipocytes	11
Lung organoids as a human system for Mycobacteria infection modeling and drug testing	11
Association of 2‐oxoacid dehydrogenase complexes with respirasomes in mitochondria	11
Structural and thermodynamic analyses of a novel β‐1,2‐glucan binding mode in the ABC transporter solute‐binding protein Chy400_4166 from	11
GR‐KLF15 pathway controls hepatic lipogenesis during fasting	11
The universal role of adaptive transcription in health and disease	11
Characterization of the carboxy‐terminal domain of the GPN ‐loop GTPase Npa3 reveals an intrinsica	11
KIAA0317 regulates SOCS1 stability to ameliorate colonic inflammation	11
Deciphering the structure and mechanism of action of computer‐designed mastoparan peptides	11
One ring closer to a closure: the crystal structure of the ES 3 hydroxym	11
Variability in intracellular localization of D‐amino acid oxidase in choroid plexus epithelial cells	11
Responses of animals and plants to physiological doses of ethanol: a molecular messenger of hypoxia?	11
Circadian rhythms of metabolite abundance in Drosophila are largely driven by time of feeding	11
Chromatin folding by the Polycomb group proteins and its elusive role in epigenetic repression	11
The regulation of liquid‐liquid phase separated condensates containing nucleic acids	11
Phytoplankton cell‐states: multiparameter fluorescence lifetime flow‐based monitoring reveals cellular heterogeneity	11
Comparative analysis of metabolic and functional cardiac alterations in diet‐ and genetically induced mouse models of cardiac dysfunction	11
TSC22D1 is a newly identified inhibitor of insulin secretion in pancreatic beta cells	11
Membrane anchoring of New Delhi metallo‐β‐lactamase‐1 alters the fitness of Escherichia coli and increases its susceptibility to colistin by inducing out	11
Transgenic selection and underlying mechanisms in apicomplexan parasites	11
Viscosity regulates cell spreading and cell‐extracellular matrix interactions	11
Biochemical characterization and mutational analysis of the tetrameric DABA transaminase E ct	11
Interaction with the cysteine‐free protein HAX1 expands the substrate specificity and function of MIA40	11
TBK1 is involved in M‐CSF‐induced macrophage polarization through mediating the IRF5/IRF4 axis	11
The chemoreceptor controlling the Wsp‐like transduction pathway in Halomonas titanicaeKHS3 binds and responds to purine derivatives	11
Research highlights: Hidden gems	11