OOIR: Observatory of International Research

Papers

(The H4-Index of Immunity & Ageing is 26. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
The effects of high plasma levels of Aβ1-42 on mononuclear macrophage in mouse models of Alzheimer’s disease	223
Influenza virus infection exacerbates gene expression related to neurocognitive dysfunction in brains of old mice	99
Pentraxin-3 and C-reactive protein plasma levels predict survival in older adults with or without metabolic syndrome – results of the PolSenior2 substudy	63
Natural IgG antibodies to β amyloid are decreased in patients with Parkinson’s disease	55
Cumulative physiological stress is associated with age-related changes to peripheral T lymphocyte subsets in healthy humans	55
Review of evidence linking exposure to environmental stressors and associated alterations in the dynamics of immunosenescence (ISC) with the global increase in multiple sclerosis (MS)	54
Different peripheral expression patterns of the nicotinic acetylcholine receptor in dementia with Lewy bodies and Alzheimer’s disease	53
Aging, inflammaging and immunosenescence as risk factors of severe COVID-19	52
Differential associations of anti-cytomegalovirus antibodies and soluble CD14 levels with immunosenescence in people living with HIV on long term antiretroviral therapy	52
Compositional analysis of lymphocytes and their relationship with health outcomes: findings from the health and retirement study	43
Vascular Cell Adhesion Molecule-1 (VCAM-1) contributes to macular fibrosis in neovascular age-related macular degeneration through modulating macrophage functions	39
Exploring the link between fat-soluble vitamins and aging-associated immune system status: a literature review	37
Fundamental and frontier research of immune responses to influenza vaccines in human aging: from cross-sectional and longitudinal studies to clinical trials and the geroscience perspective	37
Old hematopoietic stem cells retain competence to reconstitute a youthful B cell system that is highly responsive to protein-based vaccination	36
TAOK3 limits age-associated inflammation by negatively modulating macrophage differentiation and their production of TNFα	34
Immune cell phenotypes and mortality in the Framingham Heart Study	34
Aging and the impact of global DNA methylation, telomere shortening, and total oxidative status on sarcopenia and frailty syndrome	32
Deciphering the impact of aging on splenic endothelial cell heterogeneity and immunosenescence through single-cell RNA sequencing analysis	32
The aging immune system and all-cause mortality in older americans: differences across sex and race/ethnicity	31
Chitosan alleviates ovarian aging by enhancing macrophage phagocyte-mediated tissue homeostasis	30
Several areas of overlap between obesity and aging indicate obesity as a biomarker of accelerated aging of human B cell function and antibody responses	30
Inhibition of the MEK/ERK pathway suppresses immune overactivation and mitigates TDP-43 toxicity in a Drosophila model of ALS	30
Systemic immune response in young and elderly patients after traumatic brain injury	29
Association of adipose tissue inflammation and physical fitness in older adults	28
MicroRNA-425-5p modulates osteoporosis by targeting annexin A2	28

The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people