OOIR: Observatory of International Research

Papers

(The median citation count of Immunity & Ageing is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Role of immune cells in the removal of deleterious senescent cells	188
Gut microbiota as the key controllers of “healthy” aging of elderly people	167
Obesity and COVID-19: what makes obese host so vulnerable?	122
The immune response to influenza in older humans: beyond immune senescence	98
The correlation between the Th17/Treg cell balance and bone health	63
Aging induces B cell defects and decreased antibody responses to influenza infection and vaccination	63
Differential immunogenicity of BNT162b2 or ChAdOx1 vaccines after extended-interval homologous dual vaccination in older people	63
The lethal sex gap: COVID-19	61
A public health perspective of aging: do hyper-inflammatory syndromes such as COVID-19, SARS, ARDS, cytokine storm syndrome, and post-ICU syndrome accelerate short- and long-term inflammaging?	59
“The ancient and the new”: is there an interaction between cytomegalovirus and SARS-CoV-2 infection?	50
SARS-CoV-2 disease severity and diabetes: why the connection and what is to be done?	49
Functional conservation in genes and pathways linking ageing and immunity	44
SARS-CoV-2 and mitochondrial health: implications of lifestyle and ageing	43
Genetic and environmental determinants of human TCR repertoire diversity	42
Macrophage function in the elderly and impact on injury repair and cancer	41
Autoimmune hemolytic anemia: current knowledge and perspectives	39
Does reactivation of cytomegalovirus contribute to severe COVID-19 disease?	38
Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease	38
Sex- and age‐dependent alterations of splenic immune cell profile and NK cell phenotypes and function in C57BL/6J mice	37
COVID-19: age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective study	33
Aging, inflammaging and immunosenescence as risk factors of severe COVID-19	30
miR-181a-regulated pathways in T-cell differentiation and aging	26
Association between inflammatory cytokines and anti-SARS-CoV-2 antibodies in hospitalized patients with COVID-19	25
Aged microglia promote peripheral T cell infiltration by reprogramming the microenvironment of neurogenic niches	23
NF-κB, a culprit of both inflamm-ageing and declining immunity?	22

Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics	22
Aging and CMV discordance are associated with increased immune diversity between monozygotic twins	21
Vaccination of older adults: Influenza, pneumococcal disease, herpes zoster, COVID-19 and beyond	19
Unanticipated efficacy of SARS-CoV-2 vaccination in older adults	19
Evaluation of T-cell aging-related immune phenotypes in the context of biological aging and multimorbidity in the Health and Retirement Study	18
In-depth immune cellular profiling reveals sex-specific associations with frailty	18
Aging and chronic inflammation: highlights from a multidisciplinary workshop	18
Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice	17
Hyper‐metabolic B cells in the spleens of old mice make antibodies with autoimmune specificities	16
SARS-CoV-2 and EBV; the cost of a second mitochondrial “whammy”?	16
Phenotypic and functional alterations of monocyte subsets with aging	15
Alterations of monocyte NF-κB p65/RelA signaling in a cohort of older medical patients, age-matched controls, and healthy young adults	15
Moderate- to high intensity aerobic and resistance exercise reduces peripheral blood regulatory cell populations in older adults with rheumatoid arthritis	15
Emergence of T cell immunosenescence in diabetic chronic kidney disease	15
Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity	15
Inflammation and cell-to-cell communication, two related aspects in frailty	14
Pathogen burden and leukocyte telomere length in the United States	14
An anti-CD6 monoclonal antibody (itolizumab) reduces circulating IL-6 in severe COVID-19 elderly patients	13
Association of immunity markers with the risk of incident frailty: the Rugao longitudinal aging study	13
Rapamycin, Acarbose and 17α-estradiol share common mechanisms regulating the MAPK pathways involved in intracellular signaling and inflammation	13
Neurohormetic phytochemicals in the pathogenesis of neurodegenerative diseases	13
Different phenotypes of microglia in animal models of Alzheimer disease	12
A potential association between immunosenescence and high COVID-19 related mortality among elderly patients with cardiovascular diseases	12
Telomerase deficiency reflects age-associated changes in CD4+ T cells	12
IL-15 deficiency alleviates steroid-induced osteonecrosis of the femoral head by impact osteoclasts via RANKL-RANK-OPG system	12
Effect of aging on the transcriptomic changes associated with the expression of the HERV-K (HML-2) provirus at 1q22	12
Frailty impacts immune responses to Moderna COVID-19 mRNA vaccine in older adults	11
Toll-like receptor 4 (TLR4): new insight immune and aging	11
T cells accumulate in non-diabetic islets during ageing	10
Adiponectin deficiency accelerates brain aging via mitochondria-associated neuroinflammation	10
C-reactive protein and white blood cell are associated with frailty progression: a longitudinal study	10
Metabolic phenotype of B cells from young and elderly HIV individuals	10
The impact of circadian rhythms on the immune response to influenza vaccination in middle-aged and older adults (IMPROVE): a randomised controlled trial	10
The impact of body mass index on adaptive immune cells in the human bone marrow	10
T cell phenotypes associated with insulin resistance: results from the Berlin Aging Study II	10
The effect of age on CD4+ T-cell recovery in HIV-suppressed adult participants: a sub-study from AIDS Clinical Trial Group (ACTG) A5321 and the Bone Loss and Immune Reconstitution (BLIR) study	9
MicroRNAs: a crossroad that connects obesity to immunity and aging	9
Age-associated phenotypic imbalance in TCD4 and TCD8 cell subsets: comparison between healthy aged, smokers, COPD patients and young adults	9
Loss of toll-like receptor 4 ameliorates cardiovascular dysfunction in aged mice	9
Salutary effects of moderate but not high intensity aerobic exercise training on the frequency of peripheral T-cells associated with immunosenescence in older women at high risk of breast cancer: a ra	9
Plasma level of lipocalin 2 is increased in neovascular age-related macular degeneration patients, particularly those with macular fibrosis	9
Neutralizing antibody and T cell responses against SARS-CoV-2 variants of concern following ChAdOx-1 or BNT162b2 boosting in the elderly previously immunized with CoronaVac vaccine	9
Short-term zinc supplementation of zinc-deficient seniors counteracts CREMα - mediated IL-2 suppression	8
Excessive IL-15 promotes cytotoxic CD4 + CD28− T cell-mediated renal injury in lupus nephritis	8
Aging in psoriasis vulgaris: female patients are epigenetically older than healthy controls	8
Reduced immune-regulatory molecule expression on human colonic memory CD4 T cells in older adults	8
Evidence of telomere attrition and a potential role for DNA damage in systemic sclerosis	8
Impaired JAK-STAT pathway signaling in leukocytes of the frail elderly	8
Classical and lectin complement pathways and markers of inflammation for investigation of susceptibility to infections among healthy older adults	8
Age-dependency of terminal ileum tissue resident memory T cell responsiveness profiles to S. Typhi following oral Ty21a immunization in humans	8

Sex differences in inflammation in the hippocampus and amygdala across the lifespan in rats: associations with cognitive bias	8
A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age	8
Effect of age and sex on immune checkpoint expression and kinetics in human T cells	8
The age again in the eye of the COVID-19 storm: evidence-based decision making	8
What’s happening where when SARS-CoV-2 infects: are TLR7 and MAFB sufficient to explain patient vulnerability?	8
ARID3a expression in human hematopoietic stem cells is associated with distinct gene patterns in aged individuals	7
The diseased kidney: aging and senescent immunology	7
Monocyte subsets display age-dependent alterations at fasting and undergo non-age-dependent changes following consumption of a meal	7
Hypothetical COVID-19 protection mechanism: hints from centenarians	7
Human MDSCs derived from the bone marrow maintain their functional ability but have a reduced frequency of induction in the elderly compared to pediatric donors	7
Age-related differences in monocyte DNA methylation and immune function in healthy Kenyan adults and children	7
Depression, aging, and immunity: implications for COVID-19 vaccine immunogenicity	7
Ageing attenuates bone healing by mesenchymal stem cells in a microribbon hydrogel with a murine long bone critical-size defect model	7
Shorter telomere length is associated with COVID-19 hospitalization and with persistence of radiographic lung abnormalities	7
Several areas of overlap between obesity and aging indicate obesity as a biomarker of accelerated aging of human B cell function and antibody responses	7
Biomarkers of cell damage, neutrophil and macrophage activation associated with in-hospital mortality in geriatric COVID-19 patients	7
Changes in T and B cell subsets in end stage renal disease patients before and after kidney transplantation	7
Investigating the potential of a prematurely aged immune phenotype in severely injured patients as predictor of risk of sepsis	7
Advanced biological age is associated with improved antibody responses in older high-dose influenza vaccine recipients over four consecutive seasons	7
An evaluation of the recognised systemic inflammatory biomarkers of chronic sub-optimal inflammation provides evidence for inflammageing (IFA) during multiple sclerosis (MS)	7
Genome-wide DNA methylation reveals potential epigenetic mechanism of age-dependent viral susceptibility in grass carp	7
Stratum corneum hydration inversely correlates with certain serum cytokine levels in the elderly, possibly contributing to inflammaging	7
Validation of the effectiveness of SARS-CoV-2 vaccines in older adults in “real-world” settings	6
Aged brain and neuroimmune responses to COVID-19: post-acute sequelae and modulatory effects of behavioral and nutritional interventions	6
Composition of the infiltrating immune cells in the brain of healthy individuals: effect of aging	6
Associations between circulating cell-free mitochondrial DNA, inflammatory markers, and cognitive and physical outcomes in community dwelling older adults	6
Markers of systemic inflammation are positively associated with influenza vaccine antibody responses with a possible role for ILT2(+)CD57(+) NK-cells	6
Glycyrrhizic acid inhibits myeloid differentiation of hematopoietic stem cells by binding S100 calcium binding protein A8 to improve cognition in aged mice	5
The reference ranges and characteristics of lymphocyte parameters and the correlation between lymphocyte parameters and routine health indicators in adults from China	5
Frontline treatments in extremely elderly patients with diffuse large B-cell lymphoma: a population-based study in Taiwan, 2010–2015	5
May critical molecular cross-talk between indoleamine 2,3-dioxygenase (IDO) and arginase during human aging be targets for immunosenescence control?	5
High sensitivity C-reactive protein and glycated hemoglobin levels as dominant predictors of all-cause dementia: a nationwide population-based cohort study	5
The effect of metformin on influenza vaccine responses in nondiabetic older adults: a pilot trial	5
Herpesviruses and their genetic diversity in the blood virome of healthy individuals: effect of aging	5
Association between immunoglobulin A and depression in Chinese older adults: findings from a cross-sectional study	5
Analysis and comparison of anti-RBD neutralizing antibodies from AZD-1222, Sputnik V, Sinopharm and Covaxin vaccines and its relationship with gender among health care workers	5
High-dimensional single cell mass cytometry analysis of the murine hematopoietic system reveals signatures induced by ageing and physiological pathogen challenges	5
Antibodies in action: the role of humoral immunity in the fight against atherosclerosis	5
The accumulation of Vγ4 T cells with aging is associated with an increased adaptive Vγ4 T cell response after foodborne Listeria monocytogenes infection of mice	4
The oldest unvaccinated Covid-19 survivors in South America	4
Immunosenescence in Caenorhabditis elegans	4
Mitochondrial DNA and inflammatory proteins are higher in extracellular vesicles from frail individuals	4
Quantification of dendritic cell subsets in human thymus tissues of various ages	4
A description of the relationship in healthy longevity and aging-related disease: from gene to protein	4
Does immunosenescence drive organismal ageing via inflammageing?	4
Reproducibility of serum cytokines in an elderly population	4
Different peripheral expression patterns of the nicotinic acetylcholine receptor in dementia with Lewy bodies and Alzheimer’s disease	4
Obesity accelerates age defects in B cells, and weight loss improves B cell function	4
Frailty is related to serum inflammageing markers: results from the VITAL study	4
Telomere and mitochondria mediated the association between dietary inflammatory index and mild cognitive impairment: A prospective cohort study	4
Systemic immune response in young and elderly patients after traumatic brain injury	4
Human endogenous retroviruses and ageing	4
NKT-like (CD3 + CD56+) cells differ from T cells in expression level of cellular protective proteins and sensitivity to stimulation in the process of ageing	4