OOIR: Observatory of International Research

Papers

(The median citation count of Immunity & Ageing is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
The effects of high plasma levels of Aβ1-42 on mononuclear macrophage in mouse models of Alzheimer’s disease	402
Transient immunostimulation with LPS promotes tissue repair in aged skin	135
Influenza virus infection exacerbates gene expression related to neurocognitive dysfunction in brains of old mice	106
Review of evidence linking exposure to environmental stressors and associated alterations in the dynamics of immunosenescence (ISC) with the global increase in multiple sclerosis (MS)	96
Clinical rationale for thymic restoration in adult immunosenescence	75
Cumulative physiological stress is associated with age-related changes to peripheral T lymphocyte subsets in healthy humans	75
Natural IgG antibodies to β amyloid are decreased in patients with Parkinson’s disease	75
Reduced NK cell frequency in older patients with evolving fractures is linked to a distinct inflammatory cytokine profile	71
Pentraxin-3 and C-reactive protein plasma levels predict survival in older adults with or without metabolic syndrome – results of the PolSenior2 substudy	65
Fundamental and frontier research of immune responses to influenza vaccines in human aging: from cross-sectional and longitudinal studies to clinical trials and the geroscience perspective	62
Different peripheral expression patterns of the nicotinic acetylcholine receptor in dementia with Lewy bodies and Alzheimer’s disease	59
Differential associations of anti-cytomegalovirus antibodies and soluble CD14 levels with immunosenescence in people living with HIV on long term antiretroviral therapy	54
Compositional analysis of lymphocytes and their relationship with health outcomes: findings from the health and retirement study	50
Vascular Cell Adhesion Molecule-1 (VCAM-1) contributes to macular fibrosis in neovascular age-related macular degeneration through modulating macrophage functions	48
Exploring the link between fat-soluble vitamins and aging-associated immune system status: a literature review	47
Aging, inflammaging and immunosenescence as risk factors of severe COVID-19	46
Old hematopoietic stem cells retain competence to reconstitute a youthful B cell system that is highly responsive to protein-based vaccination	43
Immune cell phenotypes and mortality in the Framingham Heart Study	42
Aging and the impact of global DNA methylation, telomere shortening, and total oxidative status on sarcopenia and frailty syndrome	40
TAOK3 limits age-associated inflammation by negatively modulating macrophage differentiation and their production of TNFα	39
Obese plasma transfer accelerates cellular aging in the C57BL/6 mouse model	38
Deciphering the impact of aging on splenic endothelial cell heterogeneity and immunosenescence through single-cell RNA sequencing analysis	38
Several areas of overlap between obesity and aging indicate obesity as a biomarker of accelerated aging of human B cell function and antibody responses	36
The aging immune system and all-cause mortality in older americans: differences across sex and race/ethnicity	35
The neutrophil to lymphocyte ratio associates with markers of Alzheimer’s disease pathology in cognitively unimpaired elderly people	34

Chitosan alleviates ovarian aging by enhancing macrophage phagocyte-mediated tissue homeostasis	34
Systemic immune response in young and elderly patients after traumatic brain injury	33
Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol	32
Inhibition of the MEK/ERK pathway suppresses immune overactivation and mitigates TDP-43 toxicity in a Drosophila model of ALS	32
Age-dependent immune profile in healthy individuals: an original study, systematic review and meta-analysis	32
Association of adipose tissue inflammation and physical fitness in older adults	31
The use of alpha 1 thymosin as an immunomodulator of the response against SARS-Cov2	30
Characterisation of specific responses to three models of viral antigens in immunocompetent older adults	28
Advanced biological age is associated with improved antibody responses in older high-dose influenza vaccine recipients over four consecutive seasons	28
High SARS-CoV-2 antibody levels after three consecutive BNT162b2 booster vaccine doses in nursing home residents	28
Changes in the innate immune response to SARS-CoV-2 with advancing age in humans	27
Ageing results in an exacerbated inflammatory response to LPS by resident lung cells	27
Disrupted mitochondrial morphology and function exacerbate inflammation in elderly-onset ulcerative colitis	27
The role of blood related inflammatory factors on age-related macular degeneration (AMD)	27
Thymic function and survival at advance ages in nursing home residents from Southern Italy	27
Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio: results from InCHIANTI follow-up study	26
Respiratory virus immune response in the aged host	26
Inflammatory markers and physical frailty: towards clinical application	25
Systemic inflammation as a central player in the initiation and development of Alzheimer’s disease	25
Correction: Neo-epitopes emerging in the degenerative hippocampal granules of aged mice can be recognized by natural IgM auto-antibodies	25
Blood RNA-Seq profiling reveals a set of circular RNAs differentially expressed in frail individuals	25
Different phenotypes of microglia in animal models of Alzheimer disease	25
Obesity accelerates age defects in B cells, and weight loss improves B cell function	24
Impaired function of Vγ9Vδ2 T cells in frail elderly	24
Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia	23
Senescence-associated secretory phenotypes in mesenchymal cells contribute to cytotoxic immune response in oral lichen planus	23
Macrophage senescence and senescence-like states in senile osteoporosis: cellular cross-talk and therapeutic perspectives	23
Correction: The oldest unvaccinated Covid-19 survivors in South America	23
Sex-specific innate immunity and ageing in long-lived fresh water turtles (Kinosternon flavescens: Kinosternidae)	22
Immune cell signature in non-ischemic heart failure indicates chronic systemic immune activation with features of immunosenescence	22
Melatonin enhances NK cell function in aged mice by increasing T-bet expression via the JAK3-STAT5 signaling pathway	22
Crosstalk between adipogenesis and aging: role of polyphenols in combating adipogenic-associated aging	22
Aging and chronic inflammation: highlights from a multidisciplinary workshop	22
Adiponectin deficiency accelerates brain aging via mitochondria-associated neuroinflammation	22
Ascorbic acid attenuates immunosenescence and cognitive decline via MYH9-Mediated CD8⁺ T cell differentiation	21
Attenuation of OX40 signaling suppression by age disrupts peripheral deletion of CD4+ T cells specific for the epidermal autoantigen desmoglein 3	21
Physical frailty in relation to immunosenescence involving pDC function in the Japanese elderly: a cross-sectional survey study	21
Toll-like receptor 4 (TLR4): new insight immune and aging	21
Immune reconstitution efficacy and the risk factors of immune non-responsiveness after combined antiretroviral therapy in HIV-1 positive MSM and heterosexual population – a prospective cohort study	20
Neutrophil-to-lymphocyte ratio as a sex-specific predictor of short-term mortality in hospitalised older adults with COVID-19: a pragmatic biomarker of inflammaging in acute vulnerability	20
Algorithms for appropriate patient stratification in the face of a new SARS-CoV-2 pandemic	20
Targeting immunosenesence promotes clearance of senescent cells	20
Immunogenicity of adjuvanted versus high-dose inactivated influenza vaccines in older adults: a randomized clinical trial	20
The reference ranges and characteristics of lymphocyte parameters and the correlation between lymphocyte parameters and routine health indicators in adults from China	20
Heat-killed probiotic Levilactobacillus brevis MKAK9 and its exopolysaccharide promote longevity by modulating aging hallmarks and enhancing immune responses in Caenorhabditis elegans	19
Multiparity exacerbates Aβ accumulation and promotes cellular senescence in a mouse model of amyloidosis	19
An aging-related immune landscape in the hematopoietic immune system	19
Impact of NAD+ metabolism on ovarian aging	18
Secreted IgM deficiency alters the retinal landscape enhancing neurodegeneration associated with aging	18
MicroRNAs: a crossroad that connects obesity to immunity and aging	18

Gut-heart immuno-metabolic disruption associated with inflammaging and subclinical coronary artery disease in people with HIV on antiretroviral therapy	17
IL-17A promotes the progression of Alzheimer’s disease in APP/PS1 mice	17
Ageing with HIV-1: immunological challenges for effective vaccination	17
Age-stratified circulating immune signatures reveal non-invasive biomarkers for colorectal cancer detection	16
The impact of circadian rhythms on the immune response to influenza vaccination in middle-aged and older adults (IMPROVE): a randomised controlled trial	16
Correction: A genomic perspective of the aging human and mouse lung with a focus on immune response and cellular senescence	16
Warmer temperature accelerates senescence by modifying the aging-dependent changes in the mosquito transcriptome, altering immunity, metabolism, and DNA repair	16
Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport	16
The influence of structured physical activity on vaccination response from adults to older individuals: a systematic review on the Immunoinflammatory crosstalk of COVID-19	16
Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunity	16
Elicitation of protective immune responses against influenza a viruses in elderly ferrets by adjuvanted recombinant universal influenza hemagglutinin vaccines	15
sCD163, sCD28, sCD80, and sCTLA-4 as soluble marker candidates for detecting immunosenescence	15
Excessive IL-15 promotes cytotoxic CD4 + CD28− T cell-mediated renal injury in lupus nephritis	15
Obesity-associated memory impairment and neuroinflammation precede widespread peripheral perturbations in aged rats	15
The inter-link of ageing, cancer and immunity: findings from real-world retrospective study	15
Shorter telomere length is associated with COVID-19 hospitalization and with persistence of radiographic lung abnormalities	15
Potential determinants of antibody responses after vaccination against SARS-CoV-2 in older persons: the Doetinchem Cohort Study	14
Short-term zinc supplementation of zinc-deficient seniors counteracts CREMα - mediated IL-2 suppression	14
Monocyte alteration in elderly hip fracture healing: monocyte promising role in bone regeneration	14
CD8⁺ T cell heterogeneity in aging: insights from single-cell profiling	14
Inhibiting IL11: a novel approach to turning back the clock	14
Aging beyond menopause selectively decreases CD8+ T cell numbers but enhances cytotoxic activity in the human endometrium	13
Circular RNA ZBTB46 depletion alleviates the progression of Atherosclerosis by regulating the ubiquitination and degradation of hnRNPA2B1 via the AKT/mTOR pathway	13
Frailty is related to serum inflammageing markers: results from the VITAL study	12
The role of autoantibodies in bridging obesity, aging, and immunosenescence	12
Complete fatty degeneration of thymus associates with male sex, obesity and loss of circulating naïve CD8+ T cells in a Swedish middle-aged population	12
“Immunopause” no more: exercise to counter immunosenescence in aging	12
Sex differences in inflammation in the hippocampus and amygdala across the lifespan in rats: associations with cognitive bias	11
Investigating the potential of a prematurely aged immune phenotype in severely injured patients as predictor of risk of sepsis	11
Implication of IL-7 receptor alpha chain expression by CD8+ T cells and its signature in defining biomarkers in aging	11
Partial loss of Sorting Nexin 27 resembles age- and Down syndrome-associated T cell dysfunctions	11
Immunological and senescence biomarker profiles in patients after spontaneous clearance of hepatitis C virus: gender implications for long-term health risk	11
Overcoming the age-dependent SARS-CoV-2 vaccine response through hybrid immunity: analysis of humoral and cellular immunity with mass cytometry profiling	11
Kinetics of pro- and anti-inflammatory spike-specific cellular immune responses in long-term care facility residents after COVID-19 mRNA primary and booster vaccination: a prospective longitudinal stu	11
The relationship between biological aging and psoriasis: evidence from three observational studies	11
Antibodies in action: the role of humoral immunity in the fight against atherosclerosis	10
Impaired ATP hydrolysis in blood plasma contributes to age-related neutrophil dysfunction	10
Characterization of age-associated inflammasome activation reveals tissue specific differences in transcriptional and post-translational inflammatory responses	10
Adipose immune microenvironment: catalyst of age-related adipose tissue dysfunction	10
High-dose quadrivalent influenza vaccine in older adults with or without cardiovascular risk: a meta-analysis of randomized trials on 511,890 participants	10
Plasma biomarkers of immune regulation and senescence are associated with incident skeletal-related events in people with HIV: a case-cohort study	10
Growth and longevity modulation through larval environment mediate immunosenescence and immune strategy of Tenebrio molitor	10
Single-cell landscape of immunological responses in elderly patients with sepsis	9
Role of germinal center and CD39highCD73+ B cells in the age-related tonsillar involution	9
Association of leukocyte mitochondrial DNA copy number with longitudinal C-reactive protein levels and survival in older adults: a cohort study	9
Monocyte-driven inflamm-aging reduces intestinal barrier function in females	9
Short-term intensive fasting enhances the immune function of red blood cells in humans	9
Insights into the heterogeneity of pneumococcal polysaccharide vaccine immunogenicity in older adults	9
Neuroinflammation in Alzheimer’s disease: insights from peripheral immune cells	9
Frailty impacts immune responses to Moderna COVID-19 mRNA vaccine in older adults	9
Nuclear alpha-synuclein accelerates cell senescence and neurodegeneration	9
The association of multidimensional frailty with metabolic syndrome and low-grade inflammation in community-dwelling older adults in the Netherlands: a Lifelines cohort study	9
Correction: Single-cell landscape of immunological responses in elderly patients with sepsis	9
The immunological age prediction of monocytes indicates that gestational diabetes mellitus accelerates the aging of monocytes in offspring	9
Immune profiles of pre-frail people living with HIV-1: a prospective longitudinal study	9
Immune aging in annual killifish	9
Synergistic interplay between radiation and microgravity in spaceflight-related immunological health risks	9
Helicobacter pylori infection and Parkinson’s Disease: etiology, pathogenesis and levodopa bioavailability	9
Nasal administration of mesenchymal stem cells prevents accelerated age-related tauopathy after chemotherapy in mice	9
Quercetin ameliorates lupus symptoms by promoting the apoptosis of senescent Tfh cells via the Bcl-2 pathway	9
Long-term atorvastatin improves cognitive decline by regulating gut function in naturally ageing rats	8
Mouse brain contains age-dependent extraparenchymal granular structures and astrocytes, both reactive to natural IgM antibodies, linked to the fissura magna	8
Correction: Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice	8
Terminally differentiated effector memory T cells associate with cognitive and AD-related biomarkers in an aging-based community cohort	8
Repeated COVID-19 mRNA vaccination results in IgG4 class switching and decreased NK cell activation by S1-specific antibodies in older adults	8
IL-35 promotes synovial fibroblast senescence via activation of cGAS-STING-TBK1-IRF3 pathway in rheumatoid arthritis	8
The impact of ageing on the distribution of preformed anti-HLA and anti-MICA antibody specificities in recipients from eastern China prior to initial HSCT	7
A genomic perspective of the aging human and mouse lung with a focus on immune response and cellular senescence	7
Frequency of synaptic antigen-specific CD4+ T cells in dementia is age-dependent but not correlated with cognitive impairment	7
Cytomegalovirus infection reduced CD70 expression, signaling and expansion of viral specific memory CD8+ T cells in healthy human adults	7
Longitudinal humoral and memory B-cell responses to repeated SARS-CoV-2 vaccination in long-term care facilities residents	7
Delayed viral clearance and altered inflammatory responses affect severity of SARS-CoV-2 infection in aged mice	7
Immunosenescence and inflammaging in the aged horse	7
Effects of autologous serum on TREM2 and APOE in a personalized monocyte-derived macrophage assay of late-onset Alzheimer’s patients	7
Aged brain and neuroimmune responses to COVID-19: post-acute sequelae and modulatory effects of behavioral and nutritional interventions	7
Hemagglutinin virus-like particles incorporated with membrane-bound cytokine adjuvants provide protection against homologous and heterologous influenza virus challenge in aged mice	7
Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice	7
Exercise-induced changes in circulatory aging-related biomarkers among older adults: longitudinal analysis of a multi-stage randomized clinical trial	7
An immune-associated mitochondrial DNA variant with sex differences reveals a putative novel microprotein called MASL	7
Chemokine receptor 7 contributes to T- and B-cell filtering in ageing bladder, cystitis and bladder cancer	7