OOIR: Observatory of International Research

Papers

(The TQCC of Immunity & Ageing is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
What’s happening where when SARS-CoV-2 infects: are TLR7 and MAFB sufficient to explain patient vulnerability?	113
CMV infection, CD19+ B cell depletion, and Lymphopenia as predictors for unexpected admission in the institutionalized elderly	70
Cytomegalovirus infection reduced CD70 expression, signaling and expansion of viral specific memory CD8+ T cells in healthy human adults	64
Differential immunogenicity of BNT162b2 or ChAdOx1 vaccines after extended-interval homologous dual vaccination in older people	57
Chemokine receptor 7 contributes to T- and B-cell filtering in ageing bladder, cystitis and bladder cancer	53
The relationship between biological aging and psoriasis: evidence from three observational studies	50
The effects of high plasma levels of Aβ1-42 on mononuclear macrophage in mouse models of Alzheimer’s disease	47
Influenza virus infection exacerbates gene expression related to neurocognitive dysfunction in brains of old mice	46
Kinetics of pro- and anti-inflammatory spike-specific cellular immune responses in long-term care facility residents after COVID-19 mRNA primary and booster vaccination: a prospective longitudinal stu	40
Depression, aging, and immunity: implications for COVID-19 vaccine immunogenicity	39
Sex differences in inflammation in the hippocampus and amygdala across the lifespan in rats: associations with cognitive bias	35
Implication of IL-7 receptor alpha chain expression by CD8+ T cells and its signature in defining biomarkers in aging	33
Natural IgG antibodies to β amyloid are decreased in patients with Parkinson’s disease	30
Investigating the potential of a prematurely aged immune phenotype in severely injured patients as predictor of risk of sepsis	29
Review of evidence linking exposure to environmental stressors and associated alterations in the dynamics of immunosenescence (ISC) with the global increase in multiple sclerosis (MS)	28
CD161 expression defines new human γδ T cell subsets	27
May critical molecular cross-talk between indoleamine 2,3-dioxygenase (IDO) and arginase during human aging be targets for immunosenescence control?	25
Evidence of telomere attrition and a potential role for DNA damage in systemic sclerosis	23
Aged brain and neuroimmune responses to COVID-19: post-acute sequelae and modulatory effects of behavioral and nutritional interventions	22
Quantification of dendritic cell subsets in human thymus tissues of various ages	22
Cumulative physiological stress is associated with age-related changes to peripheral T lymphocyte subsets in healthy humans	21
Effects of autologous serum on TREM2 and APOE in a personalized monocyte-derived macrophage assay of late-onset Alzheimer’s patients	20
Immunological and senescence biomarker profiles in patients after spontaneous clearance of hepatitis C virus: gender implications for long-term health risk	20
Overcoming the age-dependent SARS-CoV-2 vaccine response through hybrid immunity: analysis of humoral and cellular immunity with mass cytometry profiling	20
Single-cell RNA sequencing reveals the local cell landscape in mouse epididymal initial segment during aging	20

Interseason waning of vaccine-induced hemagglutination inhibition antibody titers and contributing factors to pre-existing humoral immunity against influenza in community-dwelling older adults 75 year	20
Targeting the hallmarks of aging to improve influenza vaccine responses in older adults	20
Hemagglutinin virus-like particles incorporated with membrane-bound cytokine adjuvants provide protection against homologous and heterologous influenza virus challenge in aged mice	19
Distinct immunomodulation elicited by young versus aged extracellular vesicles in bone marrow-derived macrophages	19
Partial loss of Sorting Nexin 27 resembles age- and Down syndrome-associated T cell dysfunctions	19
Correction to: High-dimensional single cell mass cytometry analysis of the murine hematopoietic system reveals signatures induced by ageing and physiological pathogen challenges	18
Salutary effects of moderate but not high intensity aerobic exercise training on the frequency of peripheral T-cells associated with immunosenescence in older women at high risk of breast cancer: a ra	17
Correction: Neo-epitopes emerging in the degenerative hippocampal granules of aged mice can be recognized by natural IgM auto-antibodies	17
Warmer environmental temperature accelerates aging in mosquitoes, decreasing longevity and worsening infection outcomes	16
SARS-CoV-2 and EBV; the cost of a second mitochondrial “whammy”?	16
Age-related neuroimmune signatures in dorsal root ganglia of a Fabry disease mouse model	15
Obesity accelerates age defects in B cells, and weight loss improves B cell function	15
Exercise improves cognitive dysfunction and neuroinflammation in mice through Histone H3 lactylation in microglia	15
Antibodies in action: the role of humoral immunity in the fight against atherosclerosis	15
Vascular Cell Adhesion Molecule-1 (VCAM-1) contributes to macular fibrosis in neovascular age-related macular degeneration through modulating macrophage functions	14
Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease	14
Neuroinflammation in Alzheimer’s disease: insights from peripheral immune cells	14
Aged microglia promote peripheral T cell infiltration by reprogramming the microenvironment of neurogenic niches	14
Impaired ATP hydrolysis in blood plasma contributes to age-related neutrophil dysfunction	13
CD57+ EMRA CD8+ T cells in cancer patients over 70: associations with prior chemotherapy and response to anti-PD-1/PD-L1 therapy	13
CD31 + naïve T cells associate with immunosenescence and responsiveness to multiple vaccines in older adults	13
Role for BLT1 in regulating inflammation within adipose tissue immune cells of aged mice	12
Stratum corneum hydration inversely correlates with certain serum cytokine levels in the elderly, possibly contributing to inflammaging	12
NKT-like (CD3 + CD56+) cells differ from T cells in expression level of cellular protective proteins and sensitivity to stimulation in the process of ageing	12
Crosstalk between adipogenesis and aging: role of polyphenols in combating adipogenic-associated aging	12
Longevity-associated BPIFB4 gene counteracts the inflammatory signaling	12
Terminally exhausted CD8+ T cells contribute to age-dependent severity of respiratory virus infection	12
Correction: The oldest unvaccinated Covid-19 survivors in South America	12
Biomarkers of cell damage, neutrophil and macrophage activation associated with in-hospital mortality in geriatric COVID-19 patients	12
Sex-specific innate immunity and ageing in long-lived fresh water turtles (Kinosternon flavescens: Kinosternidae)	12
Blood based immune biomarkers associated with clinical frailty scale in older patients with melanoma receiving checkpoint inhibitor immunotherapy	12
Aging modifies endometrial dendritic cell function and unconventional double negative T cells in the human genital mucosa	12
Correction: Heat‑killed probiotic Levilactobacillus brevis MKAK9 and its exopolysaccharide promote longevity by modulating aging hallmarks and enhancing immune responses in Caenorhabditis elegans	11
Correction: The impact of ageing on the distribution of preformed anti-HLA and anti-MICA antibody specificities in recipients from eastern China prior to initial HSCT	11
Growth and longevity modulation through larval environment mediate immunosenescence and immune strategy of Tenebrio molitor	11
Correction to: A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age	11
Exploring the link between fat-soluble vitamins and aging-associated immune system status: a literature review	11
Inflammation scores based on C-reactive protein and albumin predict mortality in hospitalized older patients independent of the admission diagnosis	11
Markers of systemic inflammation are positively associated with influenza vaccine antibody responses with a possible role for ILT2(+)CD57(+) NK-cells	10
Herpesviruses and their genetic diversity in the blood virome of healthy individuals: effect of aging	10
Changes in T and B cell subsets in end stage renal disease patients before and after kidney transplantation	10
p16Ink4a-induced senescence in cultured mast cells as a model for ageing reveals significant morphological and functional changes	10
Evaluation of T-cell aging-related immune phenotypes in the context of biological aging and multimorbidity in the Health and Retirement Study	10
miR-181a-regulated pathways in T-cell differentiation and aging	10
The age again in the eye of the COVID-19 storm: evidence-based decision making	10
“Just right” combinations of adjuvants with nanoscale carriers activate aged dendritic cells without overt inflammation	10