Expert Opinion on Drug Delivery

Article	Citations
Dose accuracy of the follitropin alfa pen injector 2.0, the follitropin alfa:lutropin alfa 2:1 combination pen injector 2.0 and the choriogonadotropin alfa pen injector 1.0 used for fertility treatmen	66
Artificial Intelligence’s role in colon-targeted drug delivery	64
All eyes on semifluorinated alkanes: a comprehensive review of the influence of semifluorinated alkane eyedrops on tear film stabilization and drug delivery in dry eye disease	58
A tale of nucleic acid–ionizable lipid nanoparticles: Design and manufacturing technology and advancement	54
Calcium phosphate coated nanoparticles for drug delivery: where are we now?	52
In vivo dermal delivery of bleomycin with electronic pneumatic injection: drug visualization and quantification with mass spectrometry	51
Iontophoresis for the cutaneous delivery of nanoentraped drugs	51
Brain delivery enabled by transient blood–brain barrier disruption induced by regadenoson: a PET imaging study	51
Receptor-mediated nose-to-brain delivery of drug combination-loaded polymeric nanocarriers for the treatment of glioblastoma- current progress and future perspectives part II: polymeric nanocarriers f	50
How can nanoemulsions be used for photosensitizer drug delivery?	50
Challenges and opportunities in neurometabolic disease treatment with enzyme delivery	48
The quest to deliver high-dose rifampicin: can the inhaled approach help?	45
Intranasal delivery of glucagon-like peptide-1 to the brain for obesity treatment: opportunities and challenges	45
Needle-free injection of basal insulin improves fasting glucose variability as assessed by continuous glucose monitoring in T2DM: a prospective randomized multicenter open-label crossover study	43
Assessment of adherence to, and persistence with, an electromechanical autoinjector for subcutaneous interferon beta-1a injections for multiple sclerosis treatment over 3 years	41
Current insights into polymeric micelles for nasal drug delivery	40
Nanominerals: a multifaceted biomaterial for regenerative medicine and drug delivery	38
Self-assembled structures of ascorbic acid derivatives: encapsulation properties and controlled drug delivery applications	38
Pre-ANDA strategy and Human Factors activities to de-risk pharmaceutical companies ANDA submission of drug–device combination products: case study of a formative Comparative Use Human Factors study	37
The challenges of drug delivery to the esophagus and how to overcome them	37
Nuclear medicine imaging methods as novel tools in the assessment of pulmonary drug disposition	37
Hydrophobic ion pairing-based self-emulsifying drug delivery systems: a new strategy for improving the therapeutic efficacy of water-soluble drugs	36
Enhanced skin drug delivery using dissolving microneedles: a potential approach for the management of skin disorders	35
Innovative insight into the mechanism of enantioselective skin permeation for chiral drugs	34
Acetalated dextran: a novel delivery platform for particle-based vaccines	34

Magnetoliposomes for nanomedicine: synthesis, characterization, and applications in drug, gene, and peptide delivery	34
Future applications of self-immolative polymers in drug delivery	33
Stimuli-responsive image-guided nanocarriers as smart drug delivery platforms	32
Small patients, big challenges: navigating pediatric drug manipulations to prevent medication errors - a comprehensive review	32
Nanoemulsion-based dosage forms for the transdermal drug delivery applications: A review of recent advances	30
Current status and prospect for future advancements of long-acting antibody formulations	30
An update on the applications and characteristics of magnetic iron oxide nanoparticles for drug delivery	30
Novel formulations of metal-organic frameworks for controlled drug delivery	30
Do the chitosan nanoparticles really augment the drugs’ transdermal fluxes: ending the debate using meta-analysis	29
Continuous subcutaneous levodopa-carbidopa for the treatment of advanced Parkinson’s disease: is it an improvement on other delivery?	28
Engineering polycaprolactone nanowires for pharmacologic efficacy	28
Progress and potential of nanobubbles for ultrasound-mediated drug delivery	27
Silica nanoparticles for brain cancer	27
Recent advances in the use of liquid crystalline nanoparticles for non-small cell lung cancer treatment	27
Potential bladder cancer therapeutic delivery systems: a recent update	27
A randomized crossover study assessing critical errors, preferences, and ease of use of two multidose powder inhalers	27
Oral administration of M13-loaded nanoliposomes is safe and effective to treat colitis-associated cancer in mice	27
Ferulic acid’s therapeutic odyssey: nano formulations, pre-clinical investigations, and patent perspective	27
Are stimuli-responsive hybrid copolymer nanoparticles the next innovation in tumor drug delivery?	26
Current insights into drug-coated balloons for peripheral arterial disease	25
Solvent-exchange-based in situ forming implants: advances and challenges as long-lasting formulations	25
Critical review on the role of excipient properties in pharmaceutical powder-to-tablet continuous manufacturing	25
Differential targeting of olfactory epithelium and respiratory epithelium in nose-to-brain drug delivery	24
Bacterial and bacterial derivatives-based drug delivery systems: a novel approach for treating central nervous system disorders	24
3D printed dosage forms, where are we headed?	24
Can radiopharmaceuticals be delivered by quantum dots?	24
Understanding the interaction forces between shield-triggered autoinjectors and skin: an in-depth noninvasive study	23
Dimeric ferulic acid conjugate as a prodrug for brain targeting after nasal administration of loaded solid lipid microparticles	23
An overview of oral bioavailability enhancement through self-emulsifying drug delivery systems	23
Treating glioblastoma with dextrin-based polymers	23
Carbohydrates based stimulus responsive nanocarriers for cancer-targeted chemotherapy: a review of current practices	23
Laser microporation facilitates topical drug delivery: a comprehensive review about preclinical development and clinical application	22
Platelets for advanced drug delivery in cancer	22
Intramuscular injection of palmitic acid-conjugated Exendin-4 loaded multivesicular liposomes for long-acting and improving in-situ stability	22
A technology evaluation of the atypical use of a CPP-containing peptide in the formulation and performance of a clinical botulinum toxin product	22
Synthesis of a targeted, dual pH and redox-responsive nanoscale coordination polymer theranostic against metastatic breast cancer in vitro and in vivo	22
Polyphosphoester cubosomes: introducing a novel drug delivery system	21
Inhalation delivery of nucleic acid gene therapies in preclinical drug development	21
Long-acting HIV pre-exposure prophylaxis (PrEP) approaches: recent advances, emerging technologies, and development challenges	21
Evaluating the breadth of nucleic acid-based payloads delivered in lipid nanoparticles to establish fundamental differences in development	21
Future applications of cyclic antimicrobial peptides in drug delivery	21
Recent advances in antibacterial nanoformulations for endodontic applications	21
Targeted transport of biotherapeutics at the blood-brain barrier	20
Is electroporation the key to drug delivery in drug-resistant cancers?	20
3D-printed solid oral dosage forms for mental and neurological disorders: recent advances and future perspectives	20
Particle surface coating for dry powder inhaler formulations	20
Lipid-based nanosystems for wound healing	20
Pediatric inhalation therapy and the aerodynamic rationale for age-based aerosol sizes	20
Untethered shape-changing devices in the gastrointestinal tract	19
Development and approval of novel injectables: enhancing therapeutic innovations	19

Microneedles for oral mucosal delivery – Current trends and perspective on future directions	19
Topical drug delivery to the retina: obstacles and routes to success	19
Recent advances in drug delivery to the central nervous system by inhalation	19
Biphasic drug release from electrospun structures	18
An update on cell-penetrating peptides with intracellular organelle targeting	18
Metered dose inhalers in the transition to low GWP propellants: what we know and what is missing to make it happen	18
The engineering challenges and opportunities when designing potent ionizable materials for the delivery of ribonucleic acids	17
Preclinical evaluations of Norcantharidin liposome and emulsion hybrid delivery system with improved encapsulation efficiency and enhanced antitumor activity	17
Drug delivery and formulation development of hesperidin: a systematic review	17
Sustained release of brimonidine from conjunctival sac insert to reduce intraocular pressure for glaucoma treatment	17
Opportunities for enteral drug delivery for neonates, infants, and toddlers: a critical exploration	17
Influence factors on and potential strategies to amplify receptor-mediated nanodrug delivery across the blood–brain barrier	17
An evolving perspective on novel modified release drug delivery systems for inhalational therapy	17
Polymer-based thermoresponsive hydrogels for controlled drug delivery	17
Infusion-based drug delivery to the brain: what’s next?	16
Dendrimer-mediated targeting of angiogenic biomarkers: therapeutic intervention against cancer	16
An update on the latest strategies in retinal drug delivery	16
Drug and stem cells delivery to salivary glands – a concise review	16
An interview with professor Dermot O’Toole by Zoe Kenney, commissioning editor	16
Redox chemical delivery system: an innovative strategy for the treatment of neurodegenerative diseases	16
The impact of common pharmaceutical excipients on the gut microbiota	16
Nano-drug delivery system of natural products for disease prevention and treatment	16
Recent developments in nanofiber-based fast-disintegrating drug delivery systems	16
Targeting cerebral diseases with enhanced delivery of therapeutic proteins across the blood-brain barrier	15
Smart design of patient-centric long-acting products: from preclinical to marketed pipeline trends and opportunities	15
Inhaled antifungal therapy: benefits, challenges, and clinical applications	15
A fluid and particle mechanics perspective of nasal drug delivery	15
Drug delivery improvements to enable a flexible care setting for monoclonal antibody medications in oncology - Analogue-based decision framework	15
Explicit analysis of in vivo , meterological and statistical hurdles in successful clinical translation of targeted nanomedicines and plausible remedial	14
GPP-TSAIII nanocomposite hydrogel-based photothermal ablation facilitates melanoma therapy	14
The current paradigm for biologic initiation: a confirmatory quantitative analysis of self-injection training practices	14
Correction	14
Engineering trafficking pathways to overcome immunosuppressive barriers in solid tumor immunotherapy	14
Biodegradable nanoplatforms for antigen delivery: part II – nanoparticles, hydrogels, and microneedles for cancer immunotherapy	14
Future outcomes and current limitations of injectable implants for vocal fold scarring	14
Targeting the gut microbiome to control drug pharmacomicrobiomics: the next frontier in oral drug delivery	14
Development of ROS-responsive liposomes toward targeted drug delivery	14
Breast cancer epidemiology, diagnostic barriers, and contemporary trends in breast nanotheranostics and mechanisms of targeting	14
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the delivery of bioactives sourced from plants: part I – composition and production methods	14
Recent advances in nanoformulation development of Ritonavir, a key protease inhibitor used in the treatment of HIV-AIDS	13
Biomaterials-assisted construction of neoantigen vaccines for personalized cancer immunotherapy	13
Biopredictive tools for the development of injectable drug products	13
Doxorubicin-loaded graphene oxide nanocomposites in cancer medicine: stimuli-responsive carriers, co-delivery and suppressing resistance	13
Mucoadhesive drug delivery systems: a promising noninvasive approach to bioavailability enhancement. Part II: formulation considerations	13
Re-envisioning the design of nanomedicines: harnessing automation and artificial intelligence	13
Advances in plasmonic-based MOF composites, their bio-applications, and perspectives in this field	13
Advanced nano-delivery systems in H. pylori eradication: targeting, efficacy, and clinical translation	13
Solid lipid nanoparticles and nanostructured lipid carrier-based nanotherapeutics for the treatment of psoriasis	12
Biomaterials-assisted cancer vaccine delivery: preclinical landscape, challenges, and opportunities	12
The potential of a high efficacy single shot injection of artemisinin combination for effective antimalarial therapy	12
Advances in engineering and delivery strategies for cytokine immunotherapy	12
Recent advances in erythrocyte membrane-camouflaged nanoparticles for the delivery of anti-cancer therapeutics	12
Development of an intranodal drug delivery system using a mouse model with lymphadenopathy: novel discoveries and clinical application	12
Bovine serum albumin nanoparticles: a promising platform for nasal drug delivery	12
Improving antifungal lipid-based drug delivery against Candida : a review	12
Next-generation viral nanoparticles for targeted delivery of therapeutics: Fundamentals, methods, biomedical applications, and challenges	12
Solid lipid nanoparticles: a promising tool for insulin delivery	12
Subunit antigen delivery: emulsion and liposomal adjuvants for next-generation vaccines	12
The pursuit of linear dosage in pharmacy: reservoir-based drug delivery systems from macro to micro scale	12
Nanotechnology-enabled gene delivery for cancer and other genetic diseases	11
Solubility-enabling formulations for oral delivery of lipophilic drugs: considering the solubility-permeability interplay for accelerated formulation development	11
Engineered exosomes derived from stem cells: a new brain-targeted strategy	11
Topical curcumin in the treatment of denture stomatitis: a systematic review of clinical efficacy	11
Redefining drug therapy: innovative approaches using catalytic compartments	11
Preparation, thermal response mechanisms and biomedical applications of thermosensitive hydrogels for drug delivery	11
Application of zein nanoparticles for the treatment of inflammatory bowel diseases	11
Cancer bone metastases and nanotechnology-based treatment strategies	11
Nano-sized drug delivery systems to potentiate the immune checkpoint blockade therapy	11
Drug delivery systems for wound healing treatment of upper airway injury	11
Exploring nanoparticular platform in delivery of repurposed drug for Alzheimer’s disease: current approaches and future perspectives	11
Application of plant-derived extracellular vesicles as novel carriers in drug delivery systems: a review	11
Are inhaled mRNA vaccines safe and effective? A review of preclinical studies	11
siRNA therapeutics: insights, challenges, remedies and future prospects	11
Drug-eluting stents for the treatment of coronary artery disease: A review of recent advances	10
Versatility of emulgel in topical drug delivery transforming its expedition from bench to bedside	10
Polypeptides as alternatives to PEGylation of therapeutic agents	10
Lessons learned from the SARS-CoV-2 pandemic; from nucleic acid nanomedicines, to clinical trials, herd immunity, and the vaccination divide	10
Graphene quantum dots for breast cancer treatment	10
Combining experimental and computational techniques to understand and improve dry powder inhalers	10
Hydrogel formulations for orthotopic treatment of myocardial infarction	9

Delivery of mitochondria-containing extracellular vesicles to the BBB for ischemic stroke therapy	9
Role of nanotechnology in the prolonged release of drugs by the subcutaneous route	9
Biodegradable and removable implants for controlled drug delivery and release application	9
Acceptability of Cyltezo pen among biologics autoinjector patients, autoinjector naïve patients, and healthcare professionals	9
Harness arsenic in medicine: current status of arsenicals and recent advances in drug delivery	9
Orodispersible tablets for pediatric drug delivery: current challenges and recent advances	9
Metallic and lipid nanoparticles against multidrug resistant Candida : advances and translational hurdles	9
A comprehensive review of the application of 3D-bioprinting in chronic wound management	9
RNA aptamer-mediated gene therapy of prostate cancer: lessons from the past and future directions	9
Current status of porous coordination networks (PCNs) derived porphyrin spacers for cancer therapy	9
Research progress on detachable microneedles for advanced applications	9
Co-delivery of an HIV prophylactic and contraceptive using PGSU as a long-acting multipurpose prevention technology	9
Clinical insights into extracellular vesicles for targeted myocardial drug delivery	9
Performance characterization of spring-actuated prefilled pen devices for lebrikizumab and dupilumab	9
Can nanoparticle-based intranasal delivery systems revolutionize treatment of central nervous system diseases?	8
Strategies for the delivery of RNA therapeutics to diseased heart tissue	8
Essential considerations towards development of effective nasal antibiotic formulation: features, strategies, and future directions	8
Novel formulations for topical delivery of tranexamic acid: assessing the need of epidermal targeting for hyperpigmentation disorders	8
The blood–brain barrier as a treatment target for neurodegenerative disorders	8
An expert opinion on phytocompounds delivery for leishmaniasis treatment	8
In vitro modelling of intramuscular injection site events	8
Nose-to-brain drug delivery for the treatment of Alzheimer’s disease: current advancements and challenges	8
Multifunctional systems based on nano-in-microparticles as strategies for drug delivery: advances, challenges, and future perspectives	8
Biomedical applications of PLGA nanoparticles in nanomedicine: advances in drug delivery systems and cancer therapy	8
A review on the use of extracellular vesicles for the delivery of drugs and biological therapeutics	8
Nanocarrier functionalization strategies for targeted drug delivery in skin cancer therapy: current progress and upcoming challenges	8
Critical design parameters to develop biomimetic organ-on-a-chip models for the evaluation of the safety and efficacy of nanoparticles	8
Potential of nanocarrier-mediated delivery of vancomycin for MRSA infections	8
Continuous infusion aerosol delivery of prostacyclins during mechanical ventilation: challenges, limitations, and recent advances	8
Patient preferences on pen injectors for assisted reproductive technology: a discrete choice experiment in France	8
Infusion therapies for Parkinson’s disease: where are we in 2025?	8
Hydrogels for brain repair: application to Parkinson’s disease	8
Recent advances in optimizing siRNA delivery to hepatocellular carcinoma cells	8
Polyphenol-conjugated polysaccharide nanoplatforms for enhanced therapeutic efficacy	8
Nose to brain delivery of naringin-loaded chitosan nanoparticles for potential use in oxaliplatin-induced chemobrain in rats: impact on oxidative stress, cGAS/STING and HMGB1/RAGE/TLR2/MYD88 inflammat	8
Liposome-based vaccines for minimally or noninvasive administration: an update on current advancements	8
New insight into brain disease therapy: nanomedicines-crossing blood–brain barrier and extracellular space for drug delivery	8
3D printed biodegradable bilayer films: a promising frontier in liver cancer therapy	8
Dual-loaded liposomal carriers to combat chemotherapeutic resistance in breast cancer	8
Drug-eluting resorbable coronary scaffolds: a review of recent advances	8
Nasal delivery as a strategy for the prevention and treatment of COVID-19	8
Assessment of the effectiveness of intranasal antiviral therapies in preclinical SARS-CoV-2 infection mouse models: a systematic review	8
Challenges and opportunities in delivering oral peptides and proteins	7
Study of FA12 peptide-modified PEGylated liposomal doxorubicin (PLD) as an effective ligand to target Muc1 in mice bearing C26 colon carcinoma: in silico, in vitro, and in vivo study	7
Advanced drug delivery strategies for diabetic retinopathy: current therapeutic advancement, and delivery methods overcoming barriers, and experimental modalities	7
An overview of the efficacy of inhaled curcumin: a new mode of administration for an old molecule	7
Intravenous nanocrystals: fabrication, solidification, in vivo fate, and applications for cancer therapy	7
Navigating the therapeutic landscape in advanced Parkinson’s disease: a comprehensive review from infusion therapies to stem cells	7
Advances in microneedles for non-transdermal applications	7
Adverse effects of intravenous LNP-mediated mRNA therapy in clinical trials: a systematic review and meta-analysis	7
Receptor-mediated nose-to-brain delivery of drug combination-loaded polymeric nanocarriers for the treatment of glioblastoma- current progress and future perspectives part I: receptor-mediated nose-to	7
Preclinical developments in the delivery of protein antigens for vaccination	7
Pyrimethamine 3D printlets for pediatric toxoplasmosis: design, pharmacokinetics, and anti-toxoplasma activity	7
Spatiotemporal fate of nanocarriers-embedded dissolving microneedles: the impact of needle dissolving rate	7
A look to the future: cyclodextrins and cyclodextrin-based drug delivery to the retina	7
Recent developments with pH-responsive lyotropic liquid crystalline lipid nanoparticles for targeted bioactive agent delivery	7
Development of a multi-component gastroretentive expandable drug delivery system (GREDDS) for personalized administration of metformin	7
Advancements in pH-responsive nanocarriers: enhancing drug delivery for tumor therapy	7
Delivering monoclonal antibodies via inhalation: a systematic review of clinical trials in asthma and COPD	6
Current trends in PLGA based long-acting injectable products: The industry perspective	6
Every nano-step counts: a critical reflection on do’s and don’ts in researching nanomedicines for retinal gene therapy	6
High inhaler resistance does not limit successful inspiratory maneuver among patients with asthma or COPD	6
Advancements in ultrasound-mediated drug delivery for central nervous system disorders	6
Biocompatible smart micro/nanorobots for active gastrointestinal tract drug delivery	6
Programmable intratumoral drug delivery to breast cancer using wireless bioelectronic device with electrochemical actuation	6
An investigation of nano- and micron-sized carriers based on calcium carbonate and polylactic acid for oral administration of siRNA	6
Role of carbon dots as nanocarriers in drug delivery: current advancements, prospects, and implementations	6
TransCon human growth hormone for children with growth hormone deficiency: a technology evaluation	6
Alternative routes for parenteral nucleic acid delivery and related hurdles: highlights in RNA delivery	6
Challenges and considerations in liposomal hydrogels for the treatment of infection	6
Current progress of miRNA-derivative nucleotide drugs: modifications, delivery systems, applications	6
Synthetic biodegradable polyesters for implantable controlled-release devices	6
Progress of delivery methods for CRISPR-Cas9	6
Recent progress in therapeutic strategies and biomimetic nanomedicines for rheumatoid arthritis treatment	6
Lipid carrier-based intranasal delivery of calcium channel blockers for Alzheimer’s disease	6
A semi-mechanistic pharmacokinetic/pharmacodynamic model for quantifying phage-antibiotic synergy against Pseudomonas aeruginosa	6
Baicalin lipid nanocapsules for treatment of glioma: characterization, mechanistic cytotoxicity, and pharmacokinetic evaluation	6
Recent advances in mucus-penetrating nanomedicines for oral treatment of colonic diseases	6
Attenuating amygdalin (vitamin B17) toxicity for potential therapeutic uses: insights into controlled release technology-based formulations as a strategy for improving clinical safety	6
Building respirable powder architectures: utilizing polysaccharides for precise control of particle morphology for enhanced pulmonary drug delivery	6
Nanomedicine-based TRPV1 targeting for osteoarthritis therapy: promise and pitfalls	6
An update on strategies for optimizing polymer-lipid hybrid nanoparticle-mediated drug delivery: exploiting transformability and bioactivity of PLN and harnessing intracellular lipid transport mechani	6
Alternative application of an iTrack microcatheter and canaloplasty: case report and literature review	6
3D printed hollow microneedles: the latest innovation in drug delivery	5
Preparation of targeted theranostic red blood cell membranes-based nanobubbles for treatment of colon adenocarcinoma	5
Liposome-based hybrid drug delivery systems with DNA nanostructures and metallic nanoparticles	5
Magnetic hybrid nanovesicles for the precise diagnosis and treatment of central nervous system disorders	5
Dry powder inhalation, part 2: the present and future	5
3D printed personalized therapies for pediatric patients affected by adrenal insufficiency	5
Barriers for orally inhaled therapeutic antibodies	5
Current advances in cell therapeutics: a biomacromolecules application perspective	5
Recent advances in in vitro models simulating the female genital tract toward more effective intravaginal therapeutic delivery	5
An update on nanocarriers for follicular-targeted drug delivery for androgenetic alopecia topical treatment	5
Lipoplexes and polyplexes as nucleic acids delivery nanosystems: The current state and future considerations	5
Fungal quorum sensing molecules as potential drugs in the treatment of chronic wounds and their delivery	5