Expert Opinion on Drug Delivery

Article	Citations
Dual-loaded liposomal carriers to combat chemotherapeutic resistance in breast cancer	118
Intranasal administration of antiseizure drugs using new formulation trends: one step closer to reach clinical trials	56
What is the future potential of microbially degradable systems in oral drug delivery to the colon?	55
Artificial Intelligence’s role in colon-targeted drug delivery	54
Bringing intranasal drug delivery for malignancies in the brain to market	53
Recent advances in the application of clay-containing hydrogels for hemostasis and wound healing	52
In vitro modelling of intramuscular injection site events	50
Ketamine-polymer based drug delivery system for prolonged analgesia: recent advances, challenges and future prospects	44
Nose-to-brain drug delivery for the treatment of Alzheimer’s disease: current advancements and challenges	39
Essential considerations towards development of effective nasal antibiotic formulation: features, strategies, and future directions	38
Metabolism and structure of PDA as the target for new therapies: possibilities and limitations for nanotechnology	38
Magnetic hybrid nanovesicles for the precise diagnosis and treatment of central nervous system disorders	38
Hydrogels for brain repair: application to Parkinson’s disease	35
Continuous infusion aerosol delivery of prostacyclins during mechanical ventilation: challenges, limitations, and recent advances	34
Needle-free injection of basal insulin improves fasting glucose variability as assessed by continuous glucose monitoring in T2DM: a prospective randomized multicenter open-label crossover study	33
Magnetoliposomes: recent advances in the field of controlled drug delivery	32
Emerging local immunomodulatory strategies to circumvent systemic immunosuppression in cell transplantation	32
Calcium phosphate coated nanoparticles for drug delivery: where are we now?	31
How can nanoemulsions be used for photosensitizer drug delivery?	30
The blood–brain barrier as a treatment target for neurodegenerative disorders	29
The engineering challenges and opportunities when designing potent ionizable materials for the delivery of ribonucleic acids	29
All-trans retinoic acid in anticancer therapy: how nanotechnology can enhance its efficacy and resolve its drawbacks	29
An opinion on advanced cancer immunotherapy through innovations in PD-1 inhibitor delivery systems	29
In vivo dermal delivery of bleomycin with electronic pneumatic injection: drug visualization and quantification with mass spectrometry	29
Current advances in cell therapeutics: a biomacromolecules application perspective	28

Microneedles for drug delivery: recent advances in materials and geometry for preclinical and clinical studies	28
Nose to brain delivery of naringin-loaded chitosan nanoparticles for potential use in oxaliplatin-induced chemobrain in rats: impact on oxidative stress, cGAS/STING and HMGB1/RAGE/TLR2/MYD88 inflammat	26
Safety of recombinant human hyaluronidase PH20 for subcutaneous drug delivery	26
Strategies for overcoming the biological barriers associated with the administration of inhaled monoclonal antibodies for lung diseases	25
An evolving perspective on novel modified release drug delivery systems for inhalational therapy	25
Nasal delivery as a strategy for the prevention and treatment of COVID-19	25
3D printing and computer-aided design techniques for drug delivery scaffolds in tissue engineering	25
Opportunities for enteral drug delivery for neonates, infants, and toddlers: a critical exploration	24
Therapeutic nanocarriers comprising extracellular matrix-inspired peptides and polysaccharides	24
Fluorinated vectors for gene delivery	24
Peptide-based supramolecular assembly drugs toward cancer theranostics	24
Opportunities in combinational chemo-immunotherapy for breast cancer using nanotechnology: an emerging landscape	24
Nanoparticle-based drug delivery for the treatment of traumatic brain injury	23
Critical design parameters to develop biomimetic organ-on-a-chip models for the evaluation of the safety and efficacy of nanoparticles	22
Electronically powered drug delivery devices: considerations and challenges	21
Nanocarrier functionalization strategies for targeted drug delivery in skin cancer therapy: current progress and upcoming challenges	21
Advanced approaches to overcome biological barriers in respiratory and systemic routes of administration for enhanced nucleic acid delivery to the lung	21
Conjugates of amphotericin B to resolve challenges associated with its delivery	20
The quest to deliver high-dose rifampicin: can the inhaled approach help?	20
Dendrimer-mediated targeting of angiogenic biomarkers: therapeutic intervention against cancer	20
Dose accuracy of the follitropin alfa pen injector 2.0, the follitropin alfa:lutropin alfa 2:1 combination pen injector 2.0 and the choriogonadotropin alfa pen injector 1.0 used for fertility treatmen	20
Brain delivery enabled by transient blood–brain barrier disruption induced by regadenoson: a PET imaging study	19
Recent advancements on in vitro blood-brain barrier model: A reliable and efficient screening approach for preclinical and clinical investigation	19
Exploring new frontiers in drug delivery with minimally invasive microneedles: fabrication techniques, biomedical applications, and regulatory aspects	19
Challenges and opportunities in neurometabolic disease treatment with enzyme delivery	19
Utilization of endogenous albumin trafficking pathways in the lungs has potential to modestly increase the lung interstitial access and absorption of drug delivery systems after inhaled administration	19
Mucoadhesive drug delivery systems: a promising non-invasive approach to bioavailability enhancement. Part I: biophysical considerations	19
Amorphous solid dispersion to facilitate the delivery of poorly water-soluble drugs: recent advances on novel preparation processes and technology coupling	19
The current paradigm for biologic initiation: a mixed-methods exploration of practices, unmet needs, and innovation opportunities in self-injection training	19
Updated insight into the characterization of nano-emulsions	19
Sustained release of brimonidine from conjunctival sac insert to reduce intraocular pressure for glaucoma treatment	19
A review on the use of extracellular vesicles for the delivery of drugs and biological therapeutics	18
Iontophoresis for the cutaneous delivery of nanoentraped drugs	18
New insight into brain disease therapy: nanomedicines-crossing blood–brain barrier and extracellular space for drug delivery	18
Liposome-based vaccines for minimally or noninvasive administration: an update on current advancements	17
Delivery of anti-cancer drugs using microbubble-assisted ultrasound in digestive oncology: from preclinical to clinical studies	17
Bridging the gap between fundamental research and product development of long acting injectable PLGA microspheres	16
Small but powerful: will nanoparticles be the future state‐of‐the‐art therapy for IBD?	16
A tale of nucleic acid–ionizable lipid nanoparticles: Design and manufacturing technology and advancement	16
The industrial design, translation, and development strategies for long-acting peptide delivery	16
Evolution of microneedle applicators for vaccination: the role of the latch applicator in optimizing dissolving microneedle-based immunization	16
Intranasal delivery of glucagon-like peptide-1 to the brain for obesity treatment: opportunities and challenges	16
The impact of common pharmaceutical excipients on the gut microbiota	16
Barriers for orally inhaled therapeutic antibodies	16
Fungal quorum sensing molecules as potential drugs in the treatment of chronic wounds and their delivery	15
Expert opinion on antimicrobial therapies: is there enough scientific evidence to state that targeted therapies outperform non-targeted ones?	14
Transmucosal drug delivery: prospects, challenges, advances, and future directions	14
How can we advance drug delivery options using extracellular vesicles for pregnant women to reduce preterm birth?	14
Design and evaluation of chrysin-loaded nanoemulsion against lithium/pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity, oxidative stress, microglia polar	14
Biomedical applications of PLGA nanoparticles in nanomedicine: advances in drug delivery systems and cancer therapy	14

Thermosensitive liposomes: a promising step toward localised chemotherapy	14
Novel formulations for topical delivery of tranexamic acid: assessing the need of epidermal targeting for hyperpigmentation disorders	14
Injectable pulsatile drug delivery hydrogels: how do we get to the clinic?	14
Characterizing regional drug delivery within the nasal airways	13
Assessment of adherence to, and persistence with, an electromechanical autoinjector for subcutaneous interferon beta-1a injections for multiple sclerosis treatment over 3 years	13
Accelerating the development of vaccine microarray patches for epidemic response and equitable immunization coverage requires investment in microarray patch manufacturing facilities	13
An expert opinion on phytocompounds delivery for leishmaniasis treatment	13
Compared implementation of the long-acting buprenorphine treatment buvidal in four European countries	13
Targeting genetic tool for long non-coding RNA of cancer stem cells with aptamer-guided nanocarriers	13
An interview with professor Dermot O’Toole by Zoe Kenney, commissioning editor	13
Additive manufacturing of microneedles for sensing and drug delivery	13
Long-acting ocular drug delivery technologies with clinical precedent	13
Coenzyme Q10 phospholipidic vesicular formulations for treatment of androgenic alopecia:ex vivopermeation and clinical appraisal	13
Atropine in topical formulations for the management of anterior and posterior segment ocular diseases	12
Advances in microsphere-based therapies for peritoneal carcinomatosis: challenges, innovations, and future prospects	12
Recent advances on small molecular gels: formation mechanism and their application in pharmaceutical fields	12
Navigations of the targeting pathway of nanomedicines toward tumor	12
Drug delivery improvements to enable a flexible care setting for monoclonal antibody medications in oncology - Analogue-based decision framework	12
Improved biopharmaceutical attributes of lumefantrine using choline mimicking drug delivery system: preclinical investigation on NK-65 P.berghei murine model	12
Advanced drug delivery strategies for diabetic retinopathy: current therapeutic advancement, and delivery methods overcoming barriers, and experimental modalities	11
Hydrophobic ion pairing-based self-emulsifying drug delivery systems: a new strategy for improving the therapeutic efficacy of water-soluble drugs	11
Combinations of chemo-, immuno-, and gene therapies using nanocarriers as a multifunctional drug platform	11
The development of peptide-drug conjugates (PDCs) strategies for paclitaxel	11
Nuclear medicine imaging methods as novel tools in the assessment of pulmonary drug disposition	11
An insight into the role of liposomal therapeutics in the reversion of multiple sclerosis	11
The challenges of drug delivery to the esophagus and how to overcome them	11
Design and application of DNA nanostructures for organelle-targeted delivery of anticancer drugs	11
Shaping the future from the small scale: dry powder inhalation of CRISPR-Cas9 lipid nanoparticles for the treatment of lung diseases	11
Inhaled antifungal therapy: benefits, challenges, and clinical applications	11
Roadmap to discovery and early development of an mRNA loaded LNP formulation for liver therapeutic genome editing	11
Targeting cerebral diseases with enhanced delivery of therapeutic proteins across the blood-brain barrier	10
Advances in ophthalmic drug delivery technology for postoperative management after cataract surgery	10
Biopolymeric 3D printed implantable scaffolds as a potential adjuvant treatment for acute post-operative pain management	10
Recent advances in optimizing siRNA delivery to hepatocellular carcinoma cells	10
Preclinical developments in the delivery of protein antigens for vaccination	10
Enzyme-responsive mannose-grafted magnetic nanoparticles for breast and liver cancer therapy and tumor-associated macrophage immunomodulation	10
Transdermal delivery via medical device technologies	10
Patient preferences on pen injectors for assisted reproductive technology: a discrete choice experiment in France	10
Nanocarriers in topical photodynamic therapy	10
Synthetic engineered bacteria for cancer therapy	10
GPP-TSAIII nanocomposite hydrogel-based photothermal ablation facilitates melanoma therapy	10
Pre-ANDA strategy and Human Factors activities to de-risk pharmaceutical companies ANDA submission of drug–device combination products: case study of a formative Comparative Use Human Factors study	10
Translational hurdles in anti-asthmatic nanomedicine development	10
Enhanced skin drug delivery using dissolving microneedles: a potential approach for the management of skin disorders	10
Ocular delivery of Amphotericin B: current challenges and future perspectives	9
Development of a multi-component gastroretentive expandable drug delivery system (GREDDS) for personalized administration of metformin	9
Localized, on-demand, sustained drug delivery from biopolymer-based materials	9
An overview of the efficacy of inhaled curcumin: a new mode of administration for an old molecule	9
An update on the latest strategies in retinal drug delivery	9
Targeting the gut microbiome to control drug pharmacomicrobiomics: the next frontier in oral drug delivery	9
New chromatographic insights on drug:cyclodextrin inclusion complexes and their potential use in drug delivery	9
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the delivery of bioactives sourced from plants: part I – composition and production methods	9
Protein corona: challenges and opportunities for targeted delivery of nanomedicines	9
Smart design of patient-centric long-acting products: from preclinical to marketed pipeline trends and opportunities	9
Local delivery of steroids to inner ear via medical device INCAT (the Inner Ear Catheter) in partial deafness patients during cochlear implantation – preliminary results and a feasibility study	9
Novel formulations of metal-organic frameworks for controlled drug delivery	9
Mucoadhesive drug delivery systems: a promising noninvasive approach to bioavailability enhancement. Part II: formulation considerations	9
Multifunctional systems based on nano-in-microparticles as strategies for drug delivery: advances, challenges, and future perspectives	9
Drug loaded implantable devices to treat cardiovascular disease	9
Research progress in tumor targeted immunotherapy	9
4D printing chemical stimuli-responsive hydrogels for tissue engineering and localized drug delivery applications – part 2	9
Nanomicellar eye drops: a review of recent advances	8
Recent advancements in cellulose-based biomaterials for management of infected wounds	8
Development of in vitro biopharmaceutics tools for predicting the bioavailability of subcutaneously injected monoclonal antibodies and oligonucleotides	8
Study of FA12 peptide-modified PEGylated liposomal doxorubicin (PLD) as an effective ligand to target Muc1 in mice bearing C26 colon carcinoma: in silico, in vitro, and in vivo study	8
Re-envisioning the design of nanomedicines: harnessing automation and artificial intelligence	8
Fabrication of versatile targeted lipopolymersomes for improved camptothecin efficacy against colon adenocarcinoma in vitro and in vivo	8
Intratumorally anchored cytokine therapy	8
Tumor microenvironment-responsive size-switchable drug delivery nanosystems	8
An overview of regulations for bioequivalence assessment of locally acting orally inhaled drug products for the United States, Europe, Canada, and India	8
Biopredictive tools for the development of injectable drug products	8
Oral administration of M13-loaded nanoliposomes is safe and effective to treat colitis-associated cancer in mice	8
Prospective nanoparticle treatments for lymphangioleiomyomatosis	8
Doxorubicin conjugates: a practical approach for its cardiotoxicity alleviation	8
Transferrin receptor-mediated liposomal drug delivery: recent trends in targeted therapy of cancer	8
Recent advances in erythrocyte membrane-camouflaged nanoparticles for the delivery of anti-cancer therapeutics	8
Small patients, big challenges: navigating pediatric drug manipulations to prevent medication errors - a comprehensive review	8
Advances in microneedles for non-transdermal applications	7
A randomized crossover study assessing critical errors, preferences, and ease of use of two multidose powder inhalers	7
Innovative insight into the mechanism of enantioselective skin permeation for chiral drugs	7

Breast cancer epidemiology, diagnostic barriers, and contemporary trends in breast nanotheranostics and mechanisms of targeting	7
Green nanomedicine: the path to the next generation of nanomaterials for diagnosing brain tumors and therapeutics?	7
Biodegradable nanoplatforms for antigen delivery: part II – nanoparticles, hydrogels, and microneedles for cancer immunotherapy	7
Hif-1α ablation reduces the efficiency of NeuroD1 gene-based therapy and aggravates the brain damage following ischemic stroke	7
An expert opinion on respiratory delivery of high dose powders for lung infections	7
Nanoparticles as phytochemical carriers for cancer treatment: News of the last decade	7
Suprachoroidal drug delivery: a versatile therapeutic platform	7
The potential of nanosystems in disrupting adenosine signaling pathways for tumor immunotherapy	7
Doxorubicin-loaded graphene oxide nanocomposites in cancer medicine: stimuli-responsive carriers, co-delivery and suppressing resistance	7
How can pressurized gyration revolutionize drug delivery?	7
Factors affecting the preparation of nanocrystals: characterization, surface modifications and toxicity aspects	6
Continuous subcutaneous levodopa-carbidopa for the treatment of advanced Parkinson’s disease: is it an improvement on other delivery?	6
Intravenous nanocrystals: fabrication, solidification, in vivo fate, and applications for cancer therapy	6
Current status and prospect for future advancements of long-acting antibody formulations	6
The current paradigm for biologic initiation: a confirmatory quantitative analysis of self-injection training practices	6
The sustainability of emerging technologies for use in pharmaceutical manufacturing	6
A look to the future: cyclodextrins and cyclodextrin-based drug delivery to the retina	6
Understanding patient preferences for handheld autoinjectors versus wearable large-volume injectors	6
Development and evaluation of a drug-in-adhesive transdermal delivery system for delivery of olanzapine	6
Recent advances in the use of liquid crystalline nanoparticles for non-small cell lung cancer treatment	6
Pyrimethamine 3D printlets for pediatric toxoplasmosis: design, pharmacokinetics, and anti-toxoplasma activity	6
Acetalated dextran: a novel delivery platform for particle-based vaccines	6
Nanocrystals for controlled delivery: state of the art and approved drug products	6
Do the chitosan nanoparticles really augment the drugs’ transdermal fluxes: ending the debate using meta-analysis	6
Healing with herbs: an alliance with ‘nano’ for wound management	6
Biomedical Applications of polymeric micelles in the treatment of diabetes mellitus: Current success and future approaches	6
Enabling faster subcutaneous delivery of larger volume, high viscosity fluids	6
Assessing central nervous system drug delivery	6
Graphene-based materials as nanoplatforms for antiviral therapy and prophylaxis	6
Spatiotemporal fate of nanocarriers-embedded dissolving microneedles: the impact of needle dissolving rate	6
Unleashing the potential of cell membrane-based nanoparticles for COVID-19 treatment and vaccination	6
Nanotechnology-mediated delivery of resveratrol as promising strategy to improve therapeutic efficacy in triple negative breast cancer (TNBC): progress and promises	6
Advancements in pH-responsive nanocarriers: enhancing drug delivery for tumor therapy	5
Magnetic nanoparticles: multifunctional tool for cancer therapy	5
Baicalin lipid nanocapsules for treatment of glioma: characterization, mechanistic cytotoxicity, and pharmacokinetic evaluation	5
Solid lipid nanoparticles: a promising tool for insulin delivery	5
Microfluidic production of mRNA-loaded lipid nanoparticles for vaccine applications	5
The effects of airway disease on the deposition of inhaled drugs	5
Advancing of titanium medical implants by surface engineering: recent progress and challenges	5
Alternative routes for parenteral nucleic acid delivery and related hurdles: highlights in RNA delivery	5
Alginate-based matrix tablets for drug delivery	5
Polysaccharide-based hydrogels for drug delivery and wound management: a review	5
Stimuli-responsive image-guided nanocarriers as smart drug delivery platforms	5
An update on the applications and characteristics of magnetic iron oxide nanoparticles for drug delivery	5
High inhaler resistance does not limit successful inspiratory maneuver among patients with asthma or COPD	5
Nanoemulsion-based dosage forms for the transdermal drug delivery applications: A review of recent advances	5
Advances in plasmonic-based MOF composites, their bio-applications, and perspectives in this field	5
3D bioprinted microneedles: merging drug delivery and scaffold science for tissue-specific applications	5
Drug delivery in glioblastoma therapy: a review on nanoparticles targeting MGMT-mediated resistance	5
Biomaterials-assisted construction of neoantigen vaccines for personalized cancer immunotherapy	5
Recent advances in nanoformulation development of Ritonavir, a key protease inhibitor used in the treatment of HIV-AIDS	5
Challenges and opportunities in delivering oral peptides and proteins	5
Advances in soft mist inhalers	5
Solid lipid nanoparticles and nanostructured lipid carrier-based nanotherapeutics for the treatment of psoriasis	5
Ferulic acid’s therapeutic odyssey: nano formulations, pre-clinical investigations, and patent perspective	5
Design of experiment (DoE) as a quality by design (QbD) tool to optimise formulations of lipid nanoparticles for nose-to-brain drug delivery	5
Transient Permeation Enhancer® (TPE®) technology for oral delivery of octreotide: a technological evaluation	4
Critical review on the role of excipient properties in pharmaceutical powder-to-tablet continuous manufacturing	4
Sustained release ocular drug delivery systems for glaucoma therapy	4
Drug delivery systems for wound healing treatment of upper airway injury	4
Regulation of ferroptosis by nanotechnology for enhanced cancer immunotherapy	4
TransCon human growth hormone for children with growth hormone deficiency: a technology evaluation	4
Microneedles for transdermal drug delivery using clay-based composites	4
Improving antifungal lipid-based drug delivery against Candida : a review	4
Design and applications of polymer-like peptides in biomedical nanogels	4
Designing self-triggered micro/milli devices for gastrointestinal tract drug delivery	4
Receptor–mediated transcytosis of macromolecules across the blood–brain barrier	4
Subunit antigen delivery: emulsion and liposomal adjuvants for next-generation vaccines	4
Preclinical autophagy modulatory nanomedicines: big challenges, slow advances	4
Liposomal drug delivery systems for organ-specific cancer targeting: early promises, subsequent problems, and recent breakthroughs	4
Alternative application of an iTrack microcatheter and canaloplasty: case report and literature review	4
Every nano-step counts: a critical reflection on do’s and don’ts in researching nanomedicines for retinal gene therapy	4
Edible plant-derived nanotherapeutics and nanocarriers: recent progress and future directions	4
Potential bladder cancer therapeutic delivery systems: a recent update	4
Are stimuli-responsive hybrid copolymer nanoparticles the next innovation in tumor drug delivery?	4
Unification of medicines and excipients: The roles of natural excipients for promoting drug delivery	4
Aerosol delivery in interstitial lung diseases - breakthrough or lost cause?	4
Recent advances in dosage form design for the elderly: a review	4
Current trends in PLGA based long-acting injectable products: The industry perspective	4
Silica nanoparticles for brain cancer	4
Biodegradable nanoplatforms for antigen delivery: part I – state of the art review of polymeric nanoparticles for cancer immunotherapy	4
Nanotechnology-enabled gene delivery for cancer and other genetic diseases	4
Preparation, thermal response mechanisms and biomedical applications of thermosensitive hydrogels for drug delivery	4
Biomaterials-assisted cancer vaccine delivery: preclinical landscape, challenges, and opportunities	4