Expert Opinion on Drug Delivery

Article	Citations
Challenges and opportunities in neurometabolic disease treatment with enzyme delivery	58
Dose accuracy of the follitropin alfa pen injector 2.0, the follitropin alfa:lutropin alfa 2:1 combination pen injector 2.0 and the choriogonadotropin alfa pen injector 1.0 used for fertility treatmen	58
Artificial Intelligence’s role in colon-targeted drug delivery	57
Calcium phosphate coated nanoparticles for drug delivery: where are we now?	56
How can nanoemulsions be used for photosensitizer drug delivery?	54
Iontophoresis for the cutaneous delivery of nanoentraped drugs	47
In vivo dermal delivery of bleomycin with electronic pneumatic injection: drug visualization and quantification with mass spectrometry	44
Needle-free injection of basal insulin improves fasting glucose variability as assessed by continuous glucose monitoring in T2DM: a prospective randomized multicenter open-label crossover study	43
Brain delivery enabled by transient blood–brain barrier disruption induced by regadenoson: a PET imaging study	41
The quest to deliver high-dose rifampicin: can the inhaled approach help?	40
Microneedles for drug delivery: recent advances in materials and geometry for preclinical and clinical studies	40
A tale of nucleic acid–ionizable lipid nanoparticles: Design and manufacturing technology and advancement	40
Intranasal delivery of glucagon-like peptide-1 to the brain for obesity treatment: opportunities and challenges	37
Hydrophobic ion pairing-based self-emulsifying drug delivery systems: a new strategy for improving the therapeutic efficacy of water-soluble drugs	37
Nanominerals: a multifaceted biomaterial for regenerative medicine and drug delivery	37
Pre-ANDA strategy and Human Factors activities to de-risk pharmaceutical companies ANDA submission of drug–device combination products: case study of a formative Comparative Use Human Factors study	36
Nuclear medicine imaging methods as novel tools in the assessment of pulmonary drug disposition	34
Enhanced skin drug delivery using dissolving microneedles: a potential approach for the management of skin disorders	34
Assessment of adherence to, and persistence with, an electromechanical autoinjector for subcutaneous interferon beta-1a injections for multiple sclerosis treatment over 3 years	34
Current insights into polymeric micelles for nasal drug delivery	31
Self-assembled structures of ascorbic acid derivatives: encapsulation properties and controlled drug delivery applications	31
Future applications of self-immolative polymers in drug delivery	31
The challenges of drug delivery to the esophagus and how to overcome them	31
Recent advances in the use of liquid crystalline nanoparticles for non-small cell lung cancer treatment	30
Do the chitosan nanoparticles really augment the drugs’ transdermal fluxes: ending the debate using meta-analysis	30

Ferulic acid’s therapeutic odyssey: nano formulations, pre-clinical investigations, and patent perspective	29
Acetalated dextran: a novel delivery platform for particle-based vaccines	29
Small patients, big challenges: navigating pediatric drug manipulations to prevent medication errors - a comprehensive review	28
Innovative insight into the mechanism of enantioselective skin permeation for chiral drugs	27
A randomized crossover study assessing critical errors, preferences, and ease of use of two multidose powder inhalers	27
Oral administration of M13-loaded nanoliposomes is safe and effective to treat colitis-associated cancer in mice	26
Stimuli-responsive image-guided nanocarriers as smart drug delivery platforms	26
Progress and potential of nanobubbles for ultrasound-mediated drug delivery	26
Nanoemulsion-based dosage forms for the transdermal drug delivery applications: A review of recent advances	25
Continuous subcutaneous levodopa-carbidopa for the treatment of advanced Parkinson’s disease: is it an improvement on other delivery?	25
Current status and prospect for future advancements of long-acting antibody formulations	25
An update on the applications and characteristics of magnetic iron oxide nanoparticles for drug delivery	24
Magnetoliposomes for nanomedicine: synthesis, characterization, and applications in drug, gene, and peptide delivery	24
Are stimuli-responsive hybrid copolymer nanoparticles the next innovation in tumor drug delivery?	23
Novel formulations of metal-organic frameworks for controlled drug delivery	23
Can radiopharmaceuticals be delivered by quantum dots?	22
An overview of oral bioavailability enhancement through self-emulsifying drug delivery systems	22
Bacterial and bacterial derivatives-based drug delivery systems: a novel approach for treating central nervous system disorders	22
Silica nanoparticles for brain cancer	22
Critical review on the role of excipient properties in pharmaceutical powder-to-tablet continuous manufacturing	21
Current insights into drug-coated balloons for peripheral arterial disease	21
Nanotechnology-based formulations toward the improved topical delivery of anti-acne active ingredients	21
3D printed dosage forms, where are we headed?	21
Carbohydrates based stimulus responsive nanocarriers for cancer-targeted chemotherapy: a review of current practices	21
Potential bladder cancer therapeutic delivery systems: a recent update	21
Laser microporation facilitates topical drug delivery: a comprehensive review about preclinical development and clinical application	20
Long-acting HIV pre-exposure prophylaxis (PrEP) approaches: recent advances, emerging technologies, and development challenges	20
Understanding the interaction forces between shield-triggered autoinjectors and skin: an in-depth noninvasive study	20
A technology evaluation of the atypical use of a CPP-containing peptide in the formulation and performance of a clinical botulinum toxin product	20
Intramuscular injection of palmitic acid-conjugated Exendin-4 loaded multivesicular liposomes for long-acting and improving in-situ stability	20
Dimeric ferulic acid conjugate as a prodrug for brain targeting after nasal administration of loaded solid lipid microparticles	20
Synthesis of a targeted, dual pH and redox-responsive nanoscale coordination polymer theranostic against metastatic breast cancer in vitro and in vivo	20
Future applications of cyclic antimicrobial peptides in drug delivery	19
Platelets for advanced drug delivery in cancer	19
Untethered shape-changing devices in the gastrointestinal tract	19
Targeted transport of biotherapeutics at the blood-brain barrier	19
Evaluating the breadth of nucleic acid-based payloads delivered in lipid nanoparticles to establish fundamental differences in development	19
Is electroporation the key to drug delivery in drug-resistant cancers?	18
3D-printed solid oral dosage forms for mental and neurological disorders: recent advances and future perspectives	18
Lipid-based nanosystems for wound healing	18
Polyphosphoester cubosomes: introducing a novel drug delivery system	18
Recent advances in drug delivery to the central nervous system by inhalation	17
Inhalation delivery of nucleic acid gene therapies in preclinical drug development	17
Particle surface coating for dry powder inhaler formulations	17
Pediatric inhalation therapy and the aerodynamic rationale for age-based aerosol sizes	17
An update on cell-penetrating peptides with intracellular organelle targeting	17
Influence factors on and potential strategies to amplify receptor-mediated nanodrug delivery across the blood–brain barrier	16
Development and approval of novel injectables: enhancing therapeutic innovations	16
Preclinical evaluations of Norcantharidin liposome and emulsion hybrid delivery system with improved encapsulation efficiency and enhanced antitumor activity	16
Recent advances in antibacterial nanoformulations for endodontic applications	16

Microneedles for oral mucosal delivery – Current trends and perspective on future directions	16
Metered dose inhalers in the transition to low GWP propellants: what we know and what is missing to make it happen	16
Polymer-based thermoresponsive hydrogels for controlled drug delivery	15
Dendrimer-mediated targeting of angiogenic biomarkers: therapeutic intervention against cancer	15
Biphasic drug release from electrospun structures	15
Opportunities for enteral drug delivery for neonates, infants, and toddlers: a critical exploration	15
Topical drug delivery to the retina: obstacles and routes to success	15
Recent developments in nanofiber-based fast-disintegrating drug delivery systems	14
Nano-drug delivery system of natural products for disease prevention and treatment	14
The impact of common pharmaceutical excipients on the gut microbiota	14
Redox chemical delivery system: an innovative strategy for the treatment of neurodegenerative diseases	14
Sustained release of brimonidine from conjunctival sac insert to reduce intraocular pressure for glaucoma treatment	14
Smart design of patient-centric long-acting products: from preclinical to marketed pipeline trends and opportunities	14
An update on the latest strategies in retinal drug delivery	14
An evolving perspective on novel modified release drug delivery systems for inhalational therapy	14
An interview with professor Dermot O’Toole by Zoe Kenney, commissioning editor	14
Targeting the gut microbiome to control drug pharmacomicrobiomics: the next frontier in oral drug delivery	14
Targeting cerebral diseases with enhanced delivery of therapeutic proteins across the blood-brain barrier	14
The engineering challenges and opportunities when designing potent ionizable materials for the delivery of ribonucleic acids	14
Inhaled antifungal therapy: benefits, challenges, and clinical applications	14
Drug delivery improvements to enable a flexible care setting for monoclonal antibody medications in oncology - Analogue-based decision framework	14
GPP-TSAIII nanocomposite hydrogel-based photothermal ablation facilitates melanoma therapy	13
Biodegradable nanoplatforms for antigen delivery: part II – nanoparticles, hydrogels, and microneedles for cancer immunotherapy	13
Biomaterials-assisted construction of neoantigen vaccines for personalized cancer immunotherapy	13
The current paradigm for biologic initiation: a confirmatory quantitative analysis of self-injection training practices	13
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the delivery of bioactives sourced from plants: part I – composition and production methods	13
Biopredictive tools for the development of injectable drug products	13
Recent advances in nanoformulation development of Ritonavir, a key protease inhibitor used in the treatment of HIV-AIDS	13
Re-envisioning the design of nanomedicines: harnessing automation and artificial intelligence	12
Advances in plasmonic-based MOF composites, their bio-applications, and perspectives in this field	12
Exploring space-energy matching via quantum-molecular mechanics modeling and breakage dynamics-energy dissipation via microhydrodynamic modeling to improve the screening efficiency of nanosuspension p	12
Bovine serum albumin nanoparticles: a promising platform for nasal drug delivery	12
Solid lipid nanoparticles: a promising tool for insulin delivery	12
Breast cancer epidemiology, diagnostic barriers, and contemporary trends in breast nanotheranostics and mechanisms of targeting	12
Subunit antigen delivery: emulsion and liposomal adjuvants for next-generation vaccines	12
Biomaterials-assisted cancer vaccine delivery: preclinical landscape, challenges, and opportunities	12
Solid lipid nanoparticles and nanostructured lipid carrier-based nanotherapeutics for the treatment of psoriasis	12
Mucoadhesive drug delivery systems: a promising noninvasive approach to bioavailability enhancement. Part II: formulation considerations	12
Recent advances in erythrocyte membrane-camouflaged nanoparticles for the delivery of anti-cancer therapeutics	12
Doxorubicin-loaded graphene oxide nanocomposites in cancer medicine: stimuli-responsive carriers, co-delivery and suppressing resistance	12
Improving antifungal lipid-based drug delivery against Candida : a review	12
Engineered exosomes derived from stem cells: a new brain-targeted strategy	11
Nanotechnology-enabled gene delivery for cancer and other genetic diseases	11
Preparation, thermal response mechanisms and biomedical applications of thermosensitive hydrogels for drug delivery	11
Versatility of emulgel in topical drug delivery transforming its expedition from bench to bedside	11
Next-generation viral nanoparticles for targeted delivery of therapeutics: Fundamentals, methods, biomedical applications, and challenges	11
Drug delivery systems for wound healing treatment of upper airway injury	11
Advances in engineering and delivery strategies for cytokine immunotherapy	11
Exploring nanoparticular platform in delivery of repurposed drug for Alzheimer’s disease: current approaches and future perspectives	11
Development of an intranodal drug delivery system using a mouse model with lymphadenopathy: novel discoveries and clinical application	11
The pursuit of linear dosage in pharmacy: reservoir-based drug delivery systems from macro to micro scale	11
Application of plant-derived extracellular vesicles as novel carriers in drug delivery systems: a review	10
Are inhaled mRNA vaccines safe and effective? A review of preclinical studies	10
Nano-sized drug delivery systems to potentiate the immune checkpoint blockade therapy	10
Potential of nanocarrier-mediated delivery of vancomycin for MRSA infections	10
Harness arsenic in medicine: current status of arsenicals and recent advances in drug delivery	10
Drug-eluting stents for the treatment of coronary artery disease: A review of recent advances	10
Solubility-enabling formulations for oral delivery of lipophilic drugs: considering the solubility-permeability interplay for accelerated formulation development	10
Redefining drug therapy: innovative approaches using catalytic compartments	10
Combining experimental and computational techniques to understand and improve dry powder inhalers	10
Acceptability of Cyltezo pen among biologics autoinjector patients, autoinjector naïve patients, and healthcare professionals	10
Graphene quantum dots for breast cancer treatment	10
Cancer bone metastases and nanotechnology-based treatment strategies	10
Polypeptides as alternatives to PEGylation of therapeutic agents	10
siRNA therapeutics: insights, challenges, remedies and future prospects	10
Lessons learned from the SARS-CoV-2 pandemic; from nucleic acid nanomedicines, to clinical trials, herd immunity, and the vaccination divide	10
Research progress on detachable microneedles for advanced applications	10
Port delivery system: a novel drug delivery platform to treat retinal diseases	9
Demystifying particle-based oral vaccines	9
Orodispersible tablets for pediatric drug delivery: current challenges and recent advances	9
Co-delivery of an HIV prophylactic and contraceptive using PGSU as a long-acting multipurpose prevention technology	9
Biodegradable and removable implants for controlled drug delivery and release application	9
Delivery of mitochondria-containing extracellular vesicles to the BBB for ischemic stroke therapy	9
Oral delivery of solid lipid nanoparticles: underlining the physicochemical characteristics and physiological condition affecting the lipolysis rate	9
RNA aptamer-mediated gene therapy of prostate cancer: lessons from the past and future directions	9
Role of nanotechnology in the prolonged release of drugs by the subcutaneous route	9
Hydrogel formulations for orthotopic treatment of myocardial infarction	9
Intervention of 3D printing in health care: transformation for sustainable development	8
Current status of porous coordination networks (PCNs) derived porphyrin spacers for cancer therapy	8
Hydrogels for brain repair: application to Parkinson’s disease	8

Dual-loaded liposomal carriers to combat chemotherapeutic resistance in breast cancer	8
Novel formulations for topical delivery of tranexamic acid: assessing the need of epidermal targeting for hyperpigmentation disorders	8
A comprehensive review of the application of 3D-bioprinting in chronic wound management	8
The blood–brain barrier as a treatment target for neurodegenerative disorders	8
Nasal delivery as a strategy for the prevention and treatment of COVID-19	8
In vitro modelling of intramuscular injection site events	8
Liposome-based vaccines for minimally or noninvasive administration: an update on current advancements	8
Performance characterization of spring-actuated prefilled pen devices for lebrikizumab and dupilumab	8
Essential considerations towards development of effective nasal antibiotic formulation: features, strategies, and future directions	8
Continuous infusion aerosol delivery of prostacyclins during mechanical ventilation: challenges, limitations, and recent advances	8
New insight into brain disease therapy: nanomedicines-crossing blood–brain barrier and extracellular space for drug delivery	8
An overview of the efficacy of inhaled curcumin: a new mode of administration for an old molecule	7
Baicalin lipid nanocapsules for treatment of glioma: characterization, mechanistic cytotoxicity, and pharmacokinetic evaluation	7
Drug-eluting resorbable coronary scaffolds: a review of recent advances	7
Patient preferences on pen injectors for assisted reproductive technology: a discrete choice experiment in France	7
A review on the use of extracellular vesicles for the delivery of drugs and biological therapeutics	7
Nose to brain delivery of naringin-loaded chitosan nanoparticles for potential use in oxaliplatin-induced chemobrain in rats: impact on oxidative stress, cGAS/STING and HMGB1/RAGE/TLR2/MYD88 inflammat	7
Preclinical developments in the delivery of protein antigens for vaccination	7
A look to the future: cyclodextrins and cyclodextrin-based drug delivery to the retina	7
Development of a multi-component gastroretentive expandable drug delivery system (GREDDS) for personalized administration of metformin	7
Biomedical applications of PLGA nanoparticles in nanomedicine: advances in drug delivery systems and cancer therapy	7
Nose-to-brain drug delivery for the treatment of Alzheimer’s disease: current advancements and challenges	7
An expert opinion on phytocompounds delivery for leishmaniasis treatment	7
Advanced drug delivery strategies for diabetic retinopathy: current therapeutic advancement, and delivery methods overcoming barriers, and experimental modalities	7
Multifunctional systems based on nano-in-microparticles as strategies for drug delivery: advances, challenges, and future perspectives	7
Recent advances in optimizing siRNA delivery to hepatocellular carcinoma cells	7
Nanocarrier functionalization strategies for targeted drug delivery in skin cancer therapy: current progress and upcoming challenges	7
Critical design parameters to develop biomimetic organ-on-a-chip models for the evaluation of the safety and efficacy of nanoparticles	7
High inhaler resistance does not limit successful inspiratory maneuver among patients with asthma or COPD	6
TransCon human growth hormone for children with growth hormone deficiency: a technology evaluation	6
Programmable intratumoral drug delivery to breast cancer using wireless bioelectronic device with electrochemical actuation	6
Building respirable powder architectures: utilizing polysaccharides for precise control of particle morphology for enhanced pulmonary drug delivery	6
Advancements in ultrasound-mediated drug delivery for central nervous system disorders	6
Role of carbon dots as nanocarriers in drug delivery: current advancements, prospects, and implementations	6
Intravenous nanocrystals: fabrication, solidification, in vivo fate, and applications for cancer therapy	6
Current trends in PLGA based long-acting injectable products: The industry perspective	6
Recent progress in therapeutic strategies and biomimetic nanomedicines for rheumatoid arthritis treatment	6
Study of FA12 peptide-modified PEGylated liposomal doxorubicin (PLD) as an effective ligand to target Muc1 in mice bearing C26 colon carcinoma: in silico, in vitro, and in vivo study	6
Synthetic biodegradable polyesters for implantable controlled-release devices	6
Progress of delivery methods for CRISPR-Cas9	6
An update on strategies for optimizing polymer-lipid hybrid nanoparticle-mediated drug delivery: exploiting transformability and bioactivity of PLN and harnessing intracellular lipid transport mechani	6
An investigation of nano- and micron-sized carriers based on calcium carbonate and polylactic acid for oral administration of siRNA	6
Recent advances in mucus-penetrating nanomedicines for oral treatment of colonic diseases	6
Delivering monoclonal antibodies via inhalation: a systematic review of clinical trials in asthma and COPD	6
Advancements in pH-responsive nanocarriers: enhancing drug delivery for tumor therapy	6
Spatiotemporal fate of nanocarriers-embedded dissolving microneedles: the impact of needle dissolving rate	6
Alternative routes for parenteral nucleic acid delivery and related hurdles: highlights in RNA delivery	6
Challenges and opportunities in delivering oral peptides and proteins	6
Every nano-step counts: a critical reflection on do’s and don’ts in researching nanomedicines for retinal gene therapy	6
Alternative application of an iTrack microcatheter and canaloplasty: case report and literature review	6
Self-preserving gelatin emulgel containing whole cell probiotic for topical use: preclinical safety, efficacy, and germination studies	6
Current progress of miRNA-derivative nucleotide drugs: modifications, delivery systems, applications	6
Biocompatible smart micro/nanorobots for active gastrointestinal tract drug delivery	6
Challenges and considerations in liposomal hydrogels for the treatment of infection	6
Pyrimethamine 3D printlets for pediatric toxoplasmosis: design, pharmacokinetics, and anti-toxoplasma activity	6
Advances in microneedles for non-transdermal applications	6
Molecular insights into the antineoplastic potential of apigenin and its derivatives: paving the way for nanotherapeutic innovations	5
Preparation of targeted theranostic red blood cell membranes-based nanobubbles for treatment of colon adenocarcinoma	5
Improving adherence by investigating the stability of dabigatran outside of the manufacturer’s original packaging: a New Zealand perspective	5
Lipoplexes and polyplexes as nucleic acids delivery nanosystems: The current state and future considerations	5
Photodynamic therapy of cancer using graphene nanomaterials	5
Liposome-based hybrid drug delivery systems with DNA nanostructures and metallic nanoparticles	5
Explicating the transformative role of artificial intelligence in designing targeted nanomedicine	5
Recent advances in targeted drug delivery for the treatment of pancreatic ductal adenocarcinoma	5
3D printed personalized therapies for pediatric patients affected by adrenal insufficiency	5
Microfabrication of controlled release osmotic drug delivery systems assembled from designed elements	5
Recent advances in in vitro models simulating the female genital tract toward more effective intravaginal therapeutic delivery	5
Cedrol-loaded dissolvable microneedles based on flexible backing for promoting hair growth	5
Chiral nanosystem and chiral supraparticles for drug delivery: an expert opinion	5
An update on nanocarriers for follicular-targeted drug delivery for androgenetic alopecia topical treatment	5
Extrusion-based systems for topical and transdermal drug delivery	5
Dry powder inhalation, part 2: the present and future	5
Advances in microsphere-based therapies for peritoneal carcinomatosis: challenges, innovations, and future prospects	4
4D printing chemical stimuli-responsive hydrogels for tissue engineering and localized drug delivery applications – part 2	4
Emerging local immunomodulatory strategies to circumvent systemic immunosuppression in cell transplantation	4
Design and evaluation of chrysin-loaded nanoemulsion against lithium/pilocarpine-induced status epilepticus in rats; emphasis on formulation, neuronal excitotoxicity, oxidative stress, microglia polar	4
Fungal quorum sensing molecules as potential drugs in the treatment of chronic wounds and their delivery	4
Nanoparticle-based drug delivery for the treatment of traumatic brain injury	4
Assessing central nervous system drug delivery	4
Transfersomes: a next-generation drug delivery system for topical ocular drug delivery	4
Nanocarriers in topical photodynamic therapy	4
Translational hurdles in anti-asthmatic nanomedicine development	4
Bridging the gap between fundamental research and product development of long acting injectable PLGA microspheres	4
An opinion on advanced cancer immunotherapy through innovations in PD-1 inhibitor delivery systems	4
Barriers for orally inhaled therapeutic antibodies	4
The industrial design, translation, and development strategies for long-acting peptide delivery	4
Recent advances on small molecular gels: formation mechanism and their application in pharmaceutical fields	4
Combinations of chemo-, immuno-, and gene therapies using nanocarriers as a multifunctional drug platform	4
Local delivery of steroids to inner ear via medical device INCAT (the Inner Ear Catheter) in partial deafness patients during cochlear implantation – preliminary results and a feasibility study	4
Shaping the future from the small scale: dry powder inhalation of CRISPR-Cas9 lipid nanoparticles for the treatment of lung diseases	4
Current advances in cell therapeutics: a biomacromolecules application perspective	4
3D printing and computer-aided design techniques for drug delivery scaffolds in tissue engineering	4
Electronically powered drug delivery devices: considerations and challenges	4
Biopolymeric 3D printed implantable scaffolds as a potential adjuvant treatment for acute post-operative pain management	4
Advances in ophthalmic drug delivery technology for postoperative management after cataract surgery	4