Expert Opinion on Drug Delivery

Article	Citations
Dose accuracy of the follitropin alfa pen injector 2.0, the follitropin alfa:lutropin alfa 2:1 combination pen injector 2.0 and the choriogonadotropin alfa pen injector 1.0 used for fertility treatmen	60
Challenges and opportunities in neurometabolic disease treatment with enzyme delivery	59
Artificial Intelligence’s role in colon-targeted drug delivery	57
Calcium phosphate coated nanoparticles for drug delivery: where are we now?	48
How can nanoemulsions be used for photosensitizer drug delivery?	47
Needle-free injection of basal insulin improves fasting glucose variability as assessed by continuous glucose monitoring in T2DM: a prospective randomized multicenter open-label crossover study	46
In vivo dermal delivery of bleomycin with electronic pneumatic injection: drug visualization and quantification with mass spectrometry	46
Brain delivery enabled by transient blood–brain barrier disruption induced by regadenoson: a PET imaging study	45
The quest to deliver high-dose rifampicin: can the inhaled approach help?	44
A tale of nucleic acid–ionizable lipid nanoparticles: Design and manufacturing technology and advancement	42
All eyes on semifluorinated alkanes: a comprehensive review of the influence of semifluorinated alkane eyedrops on tear film stabilization and drug delivery in dry eye disease	41
Iontophoresis for the cutaneous delivery of nanoentraped drugs	41
Intranasal delivery of glucagon-like peptide-1 to the brain for obesity treatment: opportunities and challenges	40
Nanominerals: a multifaceted biomaterial for regenerative medicine and drug delivery	37
Nuclear medicine imaging methods as novel tools in the assessment of pulmonary drug disposition	35
The challenges of drug delivery to the esophagus and how to overcome them	35
Assessment of adherence to, and persistence with, an electromechanical autoinjector for subcutaneous interferon beta-1a injections for multiple sclerosis treatment over 3 years	35
Hydrophobic ion pairing-based self-emulsifying drug delivery systems: a new strategy for improving the therapeutic efficacy of water-soluble drugs	35
Current insights into polymeric micelles for nasal drug delivery	34
Enhanced skin drug delivery using dissolving microneedles: a potential approach for the management of skin disorders	34
Do the chitosan nanoparticles really augment the drugs’ transdermal fluxes: ending the debate using meta-analysis	33
Pre-ANDA strategy and Human Factors activities to de-risk pharmaceutical companies ANDA submission of drug–device combination products: case study of a formative Comparative Use Human Factors study	33
Self-assembled structures of ascorbic acid derivatives: encapsulation properties and controlled drug delivery applications	33
Acetalated dextran: a novel delivery platform for particle-based vaccines	32
Recent advances in the use of liquid crystalline nanoparticles for non-small cell lung cancer treatment	32

Ferulic acid’s therapeutic odyssey: nano formulations, pre-clinical investigations, and patent perspective	32
Small patients, big challenges: navigating pediatric drug manipulations to prevent medication errors - a comprehensive review	31
Nanoemulsion-based dosage forms for the transdermal drug delivery applications: A review of recent advances	31
A randomized crossover study assessing critical errors, preferences, and ease of use of two multidose powder inhalers	29
Innovative insight into the mechanism of enantioselective skin permeation for chiral drugs	29
Progress and potential of nanobubbles for ultrasound-mediated drug delivery	28
Oral administration of M13-loaded nanoliposomes is safe and effective to treat colitis-associated cancer in mice	27
Stimuli-responsive image-guided nanocarriers as smart drug delivery platforms	27
Future applications of self-immolative polymers in drug delivery	26
Current status and prospect for future advancements of long-acting antibody formulations	26
Continuous subcutaneous levodopa-carbidopa for the treatment of advanced Parkinson’s disease: is it an improvement on other delivery?	26
An update on the applications and characteristics of magnetic iron oxide nanoparticles for drug delivery	25
Magnetoliposomes for nanomedicine: synthesis, characterization, and applications in drug, gene, and peptide delivery	25
Novel formulations of metal-organic frameworks for controlled drug delivery	25
Engineering polycaprolactone nanowires for pharmacologic efficacy	25
Can radiopharmaceuticals be delivered by quantum dots?	24
Bacterial and bacterial derivatives-based drug delivery systems: a novel approach for treating central nervous system disorders	24
Are stimuli-responsive hybrid copolymer nanoparticles the next innovation in tumor drug delivery?	24
Silica nanoparticles for brain cancer	23
Current insights into drug-coated balloons for peripheral arterial disease	23
An overview of oral bioavailability enhancement through self-emulsifying drug delivery systems	23
Potential bladder cancer therapeutic delivery systems: a recent update	22
3D printed dosage forms, where are we headed?	22
Critical review on the role of excipient properties in pharmaceutical powder-to-tablet continuous manufacturing	22
Platelets for advanced drug delivery in cancer	21
A technology evaluation of the atypical use of a CPP-containing peptide in the formulation and performance of a clinical botulinum toxin product	21
Understanding the interaction forces between shield-triggered autoinjectors and skin: an in-depth noninvasive study	21
Long-acting HIV pre-exposure prophylaxis (PrEP) approaches: recent advances, emerging technologies, and development challenges	21
Carbohydrates based stimulus responsive nanocarriers for cancer-targeted chemotherapy: a review of current practices	21
Intramuscular injection of palmitic acid-conjugated Exendin-4 loaded multivesicular liposomes for long-acting and improving in-situ stability	20
Future applications of cyclic antimicrobial peptides in drug delivery	20
Laser microporation facilitates topical drug delivery: a comprehensive review about preclinical development and clinical application	20
Targeted transport of biotherapeutics at the blood-brain barrier	20
Synthesis of a targeted, dual pH and redox-responsive nanoscale coordination polymer theranostic against metastatic breast cancer in vitro and in vivo	20
Evaluating the breadth of nucleic acid-based payloads delivered in lipid nanoparticles to establish fundamental differences in development	20
Dimeric ferulic acid conjugate as a prodrug for brain targeting after nasal administration of loaded solid lipid microparticles	20
Is electroporation the key to drug delivery in drug-resistant cancers?	19
Pediatric inhalation therapy and the aerodynamic rationale for age-based aerosol sizes	19
An update on cell-penetrating peptides with intracellular organelle targeting	19
Metered dose inhalers in the transition to low GWP propellants: what we know and what is missing to make it happen	19
Lipid-based nanosystems for wound healing	19
Polyphosphoester cubosomes: introducing a novel drug delivery system	19
Preclinical evaluations of Norcantharidin liposome and emulsion hybrid delivery system with improved encapsulation efficiency and enhanced antitumor activity	18
Particle surface coating for dry powder inhaler formulations	18
Inhalation delivery of nucleic acid gene therapies in preclinical drug development	18
3D-printed solid oral dosage forms for mental and neurological disorders: recent advances and future perspectives	18
Influence factors on and potential strategies to amplify receptor-mediated nanodrug delivery across the blood–brain barrier	17
Untethered shape-changing devices in the gastrointestinal tract	17
Topical drug delivery to the retina: obstacles and routes to success	17
Polymer-based thermoresponsive hydrogels for controlled drug delivery	17

Biphasic drug release from electrospun structures	17
Microneedles for oral mucosal delivery – Current trends and perspective on future directions	16
Recent advances in drug delivery to the central nervous system by inhalation	16
Development and approval of novel injectables: enhancing therapeutic innovations	16
Opportunities for enteral drug delivery for neonates, infants, and toddlers: a critical exploration	16
Recent advances in antibacterial nanoformulations for endodontic applications	16
An interview with professor Dermot O’Toole by Zoe Kenney, commissioning editor	15
The engineering challenges and opportunities when designing potent ionizable materials for the delivery of ribonucleic acids	15
The impact of common pharmaceutical excipients on the gut microbiota	15
Sustained release of brimonidine from conjunctival sac insert to reduce intraocular pressure for glaucoma treatment	15
An evolving perspective on novel modified release drug delivery systems for inhalational therapy	15
Dendrimer-mediated targeting of angiogenic biomarkers: therapeutic intervention against cancer	15
Targeting cerebral diseases with enhanced delivery of therapeutic proteins across the blood-brain barrier	14
Redox chemical delivery system: an innovative strategy for the treatment of neurodegenerative diseases	14
GPP-TSAIII nanocomposite hydrogel-based photothermal ablation facilitates melanoma therapy	14
An update on the latest strategies in retinal drug delivery	14
Drug delivery improvements to enable a flexible care setting for monoclonal antibody medications in oncology - Analogue-based decision framework	14
Recent developments in nanofiber-based fast-disintegrating drug delivery systems	14
Inhaled antifungal therapy: benefits, challenges, and clinical applications	14
Targeting the gut microbiome to control drug pharmacomicrobiomics: the next frontier in oral drug delivery	14
Smart design of patient-centric long-acting products: from preclinical to marketed pipeline trends and opportunities	14
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the delivery of bioactives sourced from plants: part I – composition and production methods	14
Nano-drug delivery system of natural products for disease prevention and treatment	14
Subunit antigen delivery: emulsion and liposomal adjuvants for next-generation vaccines	13
Biodegradable nanoplatforms for antigen delivery: part II – nanoparticles, hydrogels, and microneedles for cancer immunotherapy	13
Doxorubicin-loaded graphene oxide nanocomposites in cancer medicine: stimuli-responsive carriers, co-delivery and suppressing resistance	13
Recent advances in erythrocyte membrane-camouflaged nanoparticles for the delivery of anti-cancer therapeutics	13
Recent advances in nanoformulation development of Ritonavir, a key protease inhibitor used in the treatment of HIV-AIDS	13
Biomaterials-assisted construction of neoantigen vaccines for personalized cancer immunotherapy	13
Breast cancer epidemiology, diagnostic barriers, and contemporary trends in breast nanotheranostics and mechanisms of targeting	13
Mucoadhesive drug delivery systems: a promising noninvasive approach to bioavailability enhancement. Part II: formulation considerations	13
Solid lipid nanoparticles: a promising tool for insulin delivery	13
Biopredictive tools for the development of injectable drug products	13
The current paradigm for biologic initiation: a confirmatory quantitative analysis of self-injection training practices	13
Advances in plasmonic-based MOF composites, their bio-applications, and perspectives in this field	13
Solid lipid nanoparticles and nanostructured lipid carrier-based nanotherapeutics for the treatment of psoriasis	13
Biomaterials-assisted cancer vaccine delivery: preclinical landscape, challenges, and opportunities	12
Development of an intranodal drug delivery system using a mouse model with lymphadenopathy: novel discoveries and clinical application	12
Advances in engineering and delivery strategies for cytokine immunotherapy	12
Bovine serum albumin nanoparticles: a promising platform for nasal drug delivery	12
Exploring space-energy matching via quantum-molecular mechanics modeling and breakage dynamics-energy dissipation via microhydrodynamic modeling to improve the screening efficiency of nanosuspension p	12
Next-generation viral nanoparticles for targeted delivery of therapeutics: Fundamentals, methods, biomedical applications, and challenges	12
Re-envisioning the design of nanomedicines: harnessing automation and artificial intelligence	12
Drug delivery systems for wound healing treatment of upper airway injury	12
The pursuit of linear dosage in pharmacy: reservoir-based drug delivery systems from macro to micro scale	12
Improving antifungal lipid-based drug delivery against Candida : a review	11
Preparation, thermal response mechanisms and biomedical applications of thermosensitive hydrogels for drug delivery	11
Combining experimental and computational techniques to understand and improve dry powder inhalers	11
Nano-sized drug delivery systems to potentiate the immune checkpoint blockade therapy	11
Versatility of emulgel in topical drug delivery transforming its expedition from bench to bedside	11
Are inhaled mRNA vaccines safe and effective? A review of preclinical studies	11
Polypeptides as alternatives to PEGylation of therapeutic agents	11
Solubility-enabling formulations for oral delivery of lipophilic drugs: considering the solubility-permeability interplay for accelerated formulation development	11
Nanotechnology-enabled gene delivery for cancer and other genetic diseases	11
Exploring nanoparticular platform in delivery of repurposed drug for Alzheimer’s disease: current approaches and future perspectives	11
Engineered exosomes derived from stem cells: a new brain-targeted strategy	11
Application of plant-derived extracellular vesicles as novel carriers in drug delivery systems: a review	11
siRNA therapeutics: insights, challenges, remedies and future prospects	10
Redefining drug therapy: innovative approaches using catalytic compartments	10
Co-delivery of an HIV prophylactic and contraceptive using PGSU as a long-acting multipurpose prevention technology	10
Harness arsenic in medicine: current status of arsenicals and recent advances in drug delivery	10
Drug-eluting stents for the treatment of coronary artery disease: A review of recent advances	10
Cancer bone metastases and nanotechnology-based treatment strategies	10
Lessons learned from the SARS-CoV-2 pandemic; from nucleic acid nanomedicines, to clinical trials, herd immunity, and the vaccination divide	10
Potential of nanocarrier-mediated delivery of vancomycin for MRSA infections	10
Acceptability of Cyltezo pen among biologics autoinjector patients, autoinjector naïve patients, and healthcare professionals	10
Application of zein nanoparticles for the treatment of inflammatory bowel diseases	10
Graphene quantum dots for breast cancer treatment	10
Research progress on detachable microneedles for advanced applications	10
A comprehensive review of the application of 3D-bioprinting in chronic wound management	10
Delivery of mitochondria-containing extracellular vesicles to the BBB for ischemic stroke therapy	9
Orodispersible tablets for pediatric drug delivery: current challenges and recent advances	9
Hydrogel formulations for orthotopic treatment of myocardial infarction	9
Current status of porous coordination networks (PCNs) derived porphyrin spacers for cancer therapy	9
Role of nanotechnology in the prolonged release of drugs by the subcutaneous route	9
Performance characterization of spring-actuated prefilled pen devices for lebrikizumab and dupilumab	9
RNA aptamer-mediated gene therapy of prostate cancer: lessons from the past and future directions	9
Nanocarrier functionalization strategies for targeted drug delivery in skin cancer therapy: current progress and upcoming challenges	9
Intervention of 3D printing in health care: transformation for sustainable development	9
Oral delivery of solid lipid nanoparticles: underlining the physicochemical characteristics and physiological condition affecting the lipolysis rate	9

Biodegradable and removable implants for controlled drug delivery and release application	9
Port delivery system: a novel drug delivery platform to treat retinal diseases	9
Continuous infusion aerosol delivery of prostacyclins during mechanical ventilation: challenges, limitations, and recent advances	8
In vitro modelling of intramuscular injection site events	8
Critical design parameters to develop biomimetic organ-on-a-chip models for the evaluation of the safety and efficacy of nanoparticles	8
Biomedical applications of PLGA nanoparticles in nanomedicine: advances in drug delivery systems and cancer therapy	8
The blood–brain barrier as a treatment target for neurodegenerative disorders	8
Nose-to-brain drug delivery for the treatment of Alzheimer’s disease: current advancements and challenges	8
Patient preferences on pen injectors for assisted reproductive technology: a discrete choice experiment in France	8
Polyphenol-conjugated polysaccharide nanoplatforms for enhanced therapeutic efficacy	8
Hydrogels for brain repair: application to Parkinson’s disease	8
Dual-loaded liposomal carriers to combat chemotherapeutic resistance in breast cancer	8
Nose to brain delivery of naringin-loaded chitosan nanoparticles for potential use in oxaliplatin-induced chemobrain in rats: impact on oxidative stress, cGAS/STING and HMGB1/RAGE/TLR2/MYD88 inflammat	8
A review on the use of extracellular vesicles for the delivery of drugs and biological therapeutics	8
Recent advances in optimizing siRNA delivery to hepatocellular carcinoma cells	8
Essential considerations towards development of effective nasal antibiotic formulation: features, strategies, and future directions	8
New insight into brain disease therapy: nanomedicines-crossing blood–brain barrier and extracellular space for drug delivery	8
Novel formulations for topical delivery of tranexamic acid: assessing the need of epidermal targeting for hyperpigmentation disorders	8
Nasal delivery as a strategy for the prevention and treatment of COVID-19	8
Liposome-based vaccines for minimally or noninvasive administration: an update on current advancements	8
Strategies for the delivery of RNA therapeutics to diseased heart tissue	8
An expert opinion on phytocompounds delivery for leishmaniasis treatment	8
Advanced drug delivery strategies for diabetic retinopathy: current therapeutic advancement, and delivery methods overcoming barriers, and experimental modalities	8
Assessment of the effectiveness of intranasal antiviral therapies in preclinical SARS-CoV-2 infection mouse models: a systematic review	7
A look to the future: cyclodextrins and cyclodextrin-based drug delivery to the retina	7
Spatiotemporal fate of nanocarriers-embedded dissolving microneedles: the impact of needle dissolving rate	7
Challenges and opportunities in delivering oral peptides and proteins	7
Preclinical developments in the delivery of protein antigens for vaccination	7
Drug-eluting resorbable coronary scaffolds: a review of recent advances	7
A semi-mechanistic pharmacokinetic/pharmacodynamic model for quantifying phage-antibiotic synergy against Pseudomonas aeruginosa	7
Adverse effects of intravenous LNP-mediated mRNA therapy in clinical trials: a systematic review and meta-analysis	7
Pyrimethamine 3D printlets for pediatric toxoplasmosis: design, pharmacokinetics, and anti-toxoplasma activity	7
An overview of the efficacy of inhaled curcumin: a new mode of administration for an old molecule	7
Development of a multi-component gastroretentive expandable drug delivery system (GREDDS) for personalized administration of metformin	7
Recent developments with pH-responsive lyotropic liquid crystalline lipid nanoparticles for targeted bioactive agent delivery	7
Alternative routes for parenteral nucleic acid delivery and related hurdles: highlights in RNA delivery	7
Study of FA12 peptide-modified PEGylated liposomal doxorubicin (PLD) as an effective ligand to target Muc1 in mice bearing C26 colon carcinoma: in silico, in vitro, and in vivo study	7
Multifunctional systems based on nano-in-microparticles as strategies for drug delivery: advances, challenges, and future perspectives	7
Challenges and considerations in liposomal hydrogels for the treatment of infection	6
Current trends in PLGA based long-acting injectable products: The industry perspective	6
High inhaler resistance does not limit successful inspiratory maneuver among patients with asthma or COPD	6
Recent advances in mucus-penetrating nanomedicines for oral treatment of colonic diseases	6
Delivering monoclonal antibodies via inhalation: a systematic review of clinical trials in asthma and COPD	6
Building respirable powder architectures: utilizing polysaccharides for precise control of particle morphology for enhanced pulmonary drug delivery	6
Programmable intratumoral drug delivery to breast cancer using wireless bioelectronic device with electrochemical actuation	6
Synthetic biodegradable polyesters for implantable controlled-release devices	6
Alternative application of an iTrack microcatheter and canaloplasty: case report and literature review	6
Advancements in pH-responsive nanocarriers: enhancing drug delivery for tumor therapy	6
Advances in microneedles for non-transdermal applications	6
Intravenous nanocrystals: fabrication, solidification, in vivo fate, and applications for cancer therapy	6
Progress of delivery methods for CRISPR-Cas9	6
An update on strategies for optimizing polymer-lipid hybrid nanoparticle-mediated drug delivery: exploiting transformability and bioactivity of PLN and harnessing intracellular lipid transport mechani	6
An investigation of nano- and micron-sized carriers based on calcium carbonate and polylactic acid for oral administration of siRNA	6
Current progress of miRNA-derivative nucleotide drugs: modifications, delivery systems, applications	6
TransCon human growth hormone for children with growth hormone deficiency: a technology evaluation	6
Navigating the therapeutic landscape in advanced Parkinson’s disease: a comprehensive review from infusion therapies to stem cells	6
Every nano-step counts: a critical reflection on do’s and don’ts in researching nanomedicines for retinal gene therapy	6
Baicalin lipid nanocapsules for treatment of glioma: characterization, mechanistic cytotoxicity, and pharmacokinetic evaluation	6
Recent progress in therapeutic strategies and biomimetic nanomedicines for rheumatoid arthritis treatment	6
Advancements in ultrasound-mediated drug delivery for central nervous system disorders	6
Biocompatible smart micro/nanorobots for active gastrointestinal tract drug delivery	6
Role of carbon dots as nanocarriers in drug delivery: current advancements, prospects, and implementations	6
Molecular insights into the antineoplastic potential of apigenin and its derivatives: paving the way for nanotherapeutic innovations	5
Liposome-based hybrid drug delivery systems with DNA nanostructures and metallic nanoparticles	5
Recent advances in targeted drug delivery for the treatment of pancreatic ductal adenocarcinoma	5
Photodynamic therapy of cancer using graphene nanomaterials	5
Dry powder inhalation, part 2: the present and future	5
Microfabrication of controlled release osmotic drug delivery systems assembled from designed elements	5
3D printed personalized therapies for pediatric patients affected by adrenal insufficiency	5
3D printed hollow microneedles: the latest innovation in drug delivery	5
Chiral nanosystem and chiral supraparticles for drug delivery: an expert opinion	5
Cedrol-loaded dissolvable microneedles based on flexible backing for promoting hair growth	5
Recent advances in in vitro models simulating the female genital tract toward more effective intravaginal therapeutic delivery	5
Preparation of targeted theranostic red blood cell membranes-based nanobubbles for treatment of colon adenocarcinoma	5
Lipoplexes and polyplexes as nucleic acids delivery nanosystems: The current state and future considerations	5
Explicating the transformative role of artificial intelligence in designing targeted nanomedicine	5
Improving adherence by investigating the stability of dabigatran outside of the manufacturer’s original packaging: a New Zealand perspective	5
Extrusion-based systems for topical and transdermal drug delivery	5
An update on nanocarriers for follicular-targeted drug delivery for androgenetic alopecia topical treatment	5
Local delivery of steroids to inner ear via medical device INCAT (the Inner Ear Catheter) in partial deafness patients during cochlear implantation – preliminary results and a feasibility study	4
Biopolymeric 3D printed implantable scaffolds as a potential adjuvant treatment for acute post-operative pain management	4
Alginate-based matrix tablets for drug delivery	4
Can we create customized polypills for personalized drug formulation?	4
Nanocarriers in topical photodynamic therapy	4
4D printing chemical stimuli-responsive hydrogels for tissue engineering and localized drug delivery applications – part 2	4
Barriers for orally inhaled therapeutic antibodies	4
Nanoparticles as phytochemical carriers for cancer treatment: News of the last decade	4
Assessing central nervous system drug delivery	4
Advances in microsphere-based therapies for peritoneal carcinomatosis: challenges, innovations, and future prospects	4
Advances in ophthalmic drug delivery technology for postoperative management after cataract surgery	4
Shaping the future from the small scale: dry powder inhalation of CRISPR-Cas9 lipid nanoparticles for the treatment of lung diseases	4
Correction	4
Recent advances on small molecular gels: formation mechanism and their application in pharmaceutical fields	4
Transfersomes: a next-generation drug delivery system for topical ocular drug delivery	4
Combinations of chemo-, immuno-, and gene therapies using nanocarriers as a multifunctional drug platform	4