OOIR: Observatory of International Research

Papers

(The TQCC of Expert Opinion on Drug Delivery is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
How can nanoemulsions be used for photosensitizer drug delivery?	138
Calcium phosphate coated nanoparticles for drug delivery: where are we now?	106
Challenges and opportunities in neurometabolic disease treatment with enzyme delivery	85
Dose accuracy of the follitropin alfa pen injector 2.0, the follitropin alfa:lutropin alfa 2:1 combination pen injector 2.0 and the choriogonadotropin alfa pen injector 1.0 used for fertility treatmen	76
Receptor-mediated nose-to-brain delivery of drug combination-loaded polymeric nanocarriers for the treatment of glioblastoma- current progress and future perspectives part II: polymeric nanocarriers f	63
Artificial Intelligence’s role in colon-targeted drug delivery	61
All eyes on semifluorinated alkanes: a comprehensive review of the influence of semifluorinated alkane eyedrops on tear film stabilization and drug delivery in dry eye disease	58
The quest to deliver high-dose rifampicin: can the inhaled approach help?	57
Brain delivery enabled by transient blood–brain barrier disruption induced by regadenoson: a PET imaging study	53
Needle-free injection of basal insulin improves fasting glucose variability as assessed by continuous glucose monitoring in T2DM: a prospective randomized multicenter open-label crossover study	51
Intranasal delivery of glucagon-like peptide-1 to the brain for obesity treatment: opportunities and challenges	50
An update on the port delivery system with ranibizumab for retinal diseases	48
Theranostic metallic nanoconjugates for colorectal cancer: targeting strategies, imaging modalities, and translational challenges	47
Drug penetration in solid tumors: influence of drug size and capillary architecture	46
Iontophoresis for the cutaneous delivery of nanoentraped drugs	43
Hydrogel-based drug delivery systems for oral mucositis: a systematic review of preclinical models and translational perspectives	43
A tale of nucleic acid–ionizable lipid nanoparticles: Design and manufacturing technology and advancement	42
Nanominerals: a multifaceted biomaterial for regenerative medicine and drug delivery	41
Assessment of adherence to, and persistence with, an electromechanical autoinjector for subcutaneous interferon beta-1a injections for multiple sclerosis treatment over 3 years	41
Self-assembled structures of ascorbic acid derivatives: encapsulation properties and controlled drug delivery applications	41
Nuclear medicine imaging methods as novel tools in the assessment of pulmonary drug disposition	40
How can we optimize the delivery of IL-2 to traumatic brain injury patients?	38
Pre-ANDA strategy and Human Factors activities to de-risk pharmaceutical companies ANDA submission of drug–device combination products: case study of a formative Comparative Use Human Factors study	37
Hydrophobic ion pairing-based self-emulsifying drug delivery systems: a new strategy for improving the therapeutic efficacy of water-soluble drugs	36
Recent advances in the use of liquid crystalline nanoparticles for non-small cell lung cancer treatment	35

Current insights into polymeric micelles for nasal drug delivery	35
Mechanistic and translational frontiers on “VEGF and TKI inhibitor axitinib” : unfolding drug delivery approaches and opportunities in cancer therapy	35
Enhanced skin drug delivery using dissolving microneedles: a potential approach for the management of skin disorders	35
Penetration enhancer–containing vesicles (PEVs): from deformable liposomes to barrier-modulating delivery platforms across multiple administration routes	34
Small patients, big challenges: navigating pediatric drug manipulations to prevent medication errors - a comprehensive review	33
Peptide amphiphile nanofibers: advanced drug delivery platforms for cardiovascular therapeutics	33
Do the chitosan nanoparticles really augment the drugs’ transdermal fluxes: ending the debate using meta-analysis	33
Innovative insight into the mechanism of enantioselective skin permeation for chiral drugs	32
Engineering polycaprolactone nanowires for pharmacologic efficacy	32
Acetalated dextran: a novel delivery platform for particle-based vaccines	32
Continuous subcutaneous levodopa-carbidopa for the treatment of advanced Parkinson’s disease: is it an improvement on other delivery?	31
Current status and prospect for future advancements of long-acting antibody formulations	31
A randomized crossover study assessing critical errors, preferences, and ease of use of two multidose powder inhalers	30
Ferulic acid’s therapeutic odyssey: nano formulations, pre-clinical investigations, and patent perspective	30
Calcium carbonate in drug delivery: functional carrier design, applications, and data-driven perspectives	29
Oral administration of M13-loaded nanoliposomes is safe and effective to treat colitis-associated cancer in mice	29
Magnetoliposomes for nanomedicine: synthesis, characterization, and applications in drug, gene, and peptide delivery	28
Progress and potential of nanobubbles for ultrasound-mediated drug delivery	28
Future applications of self-immolative polymers in drug delivery	28
What role might nanolipogels play in enhancing drug delivery?	27
3D printed dosage forms, where are we headed?	27
How might intraluminal drug-delivery strategies be improved to enhance arteriovenous fistula maturation and patency?	27
The potential public health benefit of live-attenuated pertussis vaccines	27
Stimuli-responsive image-guided nanocarriers as smart drug delivery platforms	27
Solvent-exchange-based in situ forming implants: advances and challenges as long-lasting formulations	26
Current insights into drug-coated balloons for peripheral arterial disease	26
Silica nanoparticles for brain cancer	26
Potential bladder cancer therapeutic delivery systems: a recent update	26
Can radiopharmaceuticals be delivered by quantum dots?	25
Understanding the interaction forces between shield-triggered autoinjectors and skin: an in-depth noninvasive study	24
Differential targeting of olfactory epithelium and respiratory epithelium in nose-to-brain drug delivery	24
Emerging landscape of bioinformatics and artificial intelligence applications in cell-penetrating peptide-based delivery	24
Bacterial and bacterial derivatives-based drug delivery systems: a novel approach for treating central nervous system disorders	24
An overview of oral bioavailability enhancement through self-emulsifying drug delivery systems	24
Are stimuli-responsive hybrid copolymer nanoparticles the next innovation in tumor drug delivery?	24
Critical review on the role of excipient properties in pharmaceutical powder-to-tablet continuous manufacturing	24
Cyclodextrin-based carriers for targeted drug delivery	24
Advancing the current state of gene therapies using adeno-associated virus vectors to treat atrial cardiomyopathy	23
Topical film-forming systems for antifungal delivery: emerging strategies and in-depth evaluation	23
Treating glioblastoma with dextrin-based polymers	23
Intramuscular injection of palmitic acid-conjugated Exendin-4 loaded multivesicular liposomes for long-acting and improving in-situ stability	23
A technology evaluation of the atypical use of a CPP-containing peptide in the formulation and performance of a clinical botulinum toxin product	23
Dimeric ferulic acid conjugate as a prodrug for brain targeting after nasal administration of loaded solid lipid microparticles	23
Platelets for advanced drug delivery in cancer	22
Long-acting HIV pre-exposure prophylaxis (PrEP) approaches: recent advances, emerging technologies, and development challenges	22
Polyphosphoester cubosomes: introducing a novel drug delivery system	22
Laser microporation facilitates topical drug delivery: a comprehensive review about preclinical development and clinical application	22
Is electroporation the key to drug delivery in drug-resistant cancers?	21
Recent advances in antibacterial nanoformulations for endodontic applications	21
Targeted transport of biotherapeutics at the blood-brain barrier	21

Influence factors on and potential strategies to amplify receptor-mediated nanodrug delivery across the blood–brain barrier	21
3D-printed solid oral dosage forms for mental and neurological disorders: recent advances and future perspectives	21
Smart delivery systems for magnetic hyperthermia: the role of thermoresponsive drug delivery	20
Untethered shape-changing devices in the gastrointestinal tract	20
Particle surface coating for dry powder inhaler formulations	20
Evaluating the breadth of nucleic acid-based payloads delivered in lipid nanoparticles to establish fundamental differences in development	20
Inhalation delivery of nucleic acid gene therapies in preclinical drug development	20
Lipid-based nanosystems for wound healing	19
Microneedles for oral mucosal delivery – Current trends and perspective on future directions	18
Drug and stem cells delivery to salivary glands – a concise review	18
Future applications of cyclic antimicrobial peptides in drug delivery	18
Pediatric inhalation therapy and the aerodynamic rationale for age-based aerosol sizes	18
Metered dose inhalers in the transition to low GWP propellants: what we know and what is missing to make it happen	18
Biphasic drug release from electrospun structures	18
Development and approval of novel injectables: enhancing therapeutic innovations	18
An evolving perspective on novel modified release drug delivery systems for inhalational therapy	17
The impact of common pharmaceutical excipients on the gut microbiota	17
Targeted delivery of therapeutics to the heart with calcium phosphate nanoparticles	17
Where do we stand now regarding protein nanoparticles? Perspectives from the Six Thinking Hats framework	17
Drug delivery and formulation development of hesperidin: a systematic review	17
Sustained release of brimonidine from conjunctival sac insert to reduce intraocular pressure for glaucoma treatment	17
The engineering challenges and opportunities when designing potent ionizable materials for the delivery of ribonucleic acids	17
Dendrimer-mediated targeting of angiogenic biomarkers: therapeutic intervention against cancer	17
Infusion-based drug delivery to the brain: what’s next?	16
GPP-TSAIII nanocomposite hydrogel-based photothermal ablation facilitates melanoma therapy	16
Engineering trafficking pathways to overcome immunosuppressive barriers in solid tumor immunotherapy	16
Redox responsive cyclodextrin-based drug delivery systems: a special insight to glutathione responsive CD-nanosponges	16
A fluid and particle mechanics perspective of nasal drug delivery	16
Redox chemical delivery system: an innovative strategy for the treatment of neurodegenerative diseases	16
Correction	16
Nano-drug delivery system of natural products for disease prevention and treatment	15
An update on the latest strategies in retinal drug delivery	15
Explicit analysis of in vivo , meterological and statistical hurdles in successful clinical translation of targeted nanomedicines and plausible remedial	15
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the delivery of bioactives sourced from plants: part I – composition and production methods	15
Optimizing deferoxamine delivery through the skin for pressure ulcers	15
Targeting the gut microbiome to control drug pharmacomicrobiomics: the next frontier in oral drug delivery	15
Drug delivery improvements to enable a flexible care setting for monoclonal antibody medications in oncology - Analogue-based decision framework	15
Targeting cerebral diseases with enhanced delivery of therapeutic proteins across the blood-brain barrier	15
Recent advances in microneedle technology in transdermal drug delivery systems	14
Development of ROS-responsive liposomes toward targeted drug delivery	14
Rethinking probiotic delivery: new hope for preventing necrotizing enterocolitis	14
Oncofetal chondroitin sulfate in cancer therapy: a promising target for anti-tumor drug delivery?	14
Subunit antigen delivery: emulsion and liposomal adjuvants for next-generation vaccines	14
Smart design of patient-centric long-acting products: from preclinical to marketed pipeline trends and opportunities	14
Recent advances in nanoformulation development of Ritonavir, a key protease inhibitor used in the treatment of HIV-AIDS	14
Biodegradable nanoplatforms for antigen delivery: part II – nanoparticles, hydrogels, and microneedles for cancer immunotherapy	14
Future outcomes and current limitations of injectable implants for vocal fold scarring	14
Biomaterials-assisted construction of neoantigen vaccines for personalized cancer immunotherapy	14
Recent developments in nanofiber-based fast-disintegrating drug delivery systems	14
Mucoadhesive drug delivery systems: a promising noninvasive approach to bioavailability enhancement. Part II: formulation considerations	14
Advanced nano-delivery systems in H. pylori eradication: targeting, efficacy, and clinical translation	14
Recent advances in erythrocyte membrane-camouflaged nanoparticles for the delivery of anti-cancer therapeutics	14
Advances in plasmonic-based MOF composites, their bio-applications, and perspectives in this field	13
Re-envisioning the design of nanomedicines: harnessing automation and artificial intelligence	13
Next-generation viral nanoparticles for targeted delivery of therapeutics: Fundamentals, methods, biomedical applications, and challenges	13
Advances in engineering and delivery strategies for cytokine immunotherapy	13
Intra-articular targeted delivery of nanomaterials for the treatment of osteoarthritis: focusing on cell signaling pathway mechanisms	13
Breast cancer epidemiology, diagnostic barriers, and contemporary trends in breast nanotheranostics and mechanisms of targeting	13
The pursuit of linear dosage in pharmacy: reservoir-based drug delivery systems from macro to micro scale	13
The potential of a high efficacy single shot injection of artemisinin combination for effective antimalarial therapy	13
Drug delivery systems for wound healing treatment of upper airway injury	13
Next-generation strategies for PROTAC formulation: mechanistic insights and advanced formulation technologies	13
Bioinspired synthetic strategies for enhanced cell membrane interactions for targeted delivery of biomacromolecules	13
Solid lipid nanoparticles: a promising tool for insulin delivery	13
Development of an intranodal drug delivery system using a mouse model with lymphadenopathy: novel discoveries and clinical application	13
Biomaterials-assisted cancer vaccine delivery: preclinical landscape, challenges, and opportunities	13