OOIR: Observatory of International Research

Papers

(The TQCC of Expert Opinion on Drug Delivery is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Dose accuracy of the follitropin alfa pen injector 2.0, the follitropin alfa:lutropin alfa 2:1 combination pen injector 2.0 and the choriogonadotropin alfa pen injector 1.0 used for fertility treatmen	60
Challenges and opportunities in neurometabolic disease treatment with enzyme delivery	59
Artificial Intelligence’s role in colon-targeted drug delivery	57
Calcium phosphate coated nanoparticles for drug delivery: where are we now?	48
How can nanoemulsions be used for photosensitizer drug delivery?	47
Needle-free injection of basal insulin improves fasting glucose variability as assessed by continuous glucose monitoring in T2DM: a prospective randomized multicenter open-label crossover study	46
In vivo dermal delivery of bleomycin with electronic pneumatic injection: drug visualization and quantification with mass spectrometry	46
Brain delivery enabled by transient blood–brain barrier disruption induced by regadenoson: a PET imaging study	45
The quest to deliver high-dose rifampicin: can the inhaled approach help?	44
A tale of nucleic acid–ionizable lipid nanoparticles: Design and manufacturing technology and advancement	42
Iontophoresis for the cutaneous delivery of nanoentraped drugs	41
All eyes on semifluorinated alkanes: a comprehensive review of the influence of semifluorinated alkane eyedrops on tear film stabilization and drug delivery in dry eye disease	41
Intranasal delivery of glucagon-like peptide-1 to the brain for obesity treatment: opportunities and challenges	40
Nanominerals: a multifaceted biomaterial for regenerative medicine and drug delivery	37
Assessment of adherence to, and persistence with, an electromechanical autoinjector for subcutaneous interferon beta-1a injections for multiple sclerosis treatment over 3 years	35
Hydrophobic ion pairing-based self-emulsifying drug delivery systems: a new strategy for improving the therapeutic efficacy of water-soluble drugs	35
Nuclear medicine imaging methods as novel tools in the assessment of pulmonary drug disposition	35
The challenges of drug delivery to the esophagus and how to overcome them	35
Current insights into polymeric micelles for nasal drug delivery	34
Enhanced skin drug delivery using dissolving microneedles: a potential approach for the management of skin disorders	34
Self-assembled structures of ascorbic acid derivatives: encapsulation properties and controlled drug delivery applications	33
Do the chitosan nanoparticles really augment the drugs’ transdermal fluxes: ending the debate using meta-analysis	33
Pre-ANDA strategy and Human Factors activities to de-risk pharmaceutical companies ANDA submission of drug–device combination products: case study of a formative Comparative Use Human Factors study	33
Recent advances in the use of liquid crystalline nanoparticles for non-small cell lung cancer treatment	32
Ferulic acid’s therapeutic odyssey: nano formulations, pre-clinical investigations, and patent perspective	32

Acetalated dextran: a novel delivery platform for particle-based vaccines	32
Nanoemulsion-based dosage forms for the transdermal drug delivery applications: A review of recent advances	31
Small patients, big challenges: navigating pediatric drug manipulations to prevent medication errors - a comprehensive review	31
A randomized crossover study assessing critical errors, preferences, and ease of use of two multidose powder inhalers	29
Innovative insight into the mechanism of enantioselective skin permeation for chiral drugs	29
Progress and potential of nanobubbles for ultrasound-mediated drug delivery	28
Oral administration of M13-loaded nanoliposomes is safe and effective to treat colitis-associated cancer in mice	27
Stimuli-responsive image-guided nanocarriers as smart drug delivery platforms	27
Current status and prospect for future advancements of long-acting antibody formulations	26
Continuous subcutaneous levodopa-carbidopa for the treatment of advanced Parkinson’s disease: is it an improvement on other delivery?	26
Future applications of self-immolative polymers in drug delivery	26
Novel formulations of metal-organic frameworks for controlled drug delivery	25
Engineering polycaprolactone nanowires for pharmacologic efficacy	25
An update on the applications and characteristics of magnetic iron oxide nanoparticles for drug delivery	25
Magnetoliposomes for nanomedicine: synthesis, characterization, and applications in drug, gene, and peptide delivery	25
Are stimuli-responsive hybrid copolymer nanoparticles the next innovation in tumor drug delivery?	24
Can radiopharmaceuticals be delivered by quantum dots?	24
Bacterial and bacterial derivatives-based drug delivery systems: a novel approach for treating central nervous system disorders	24
An overview of oral bioavailability enhancement through self-emulsifying drug delivery systems	23
Silica nanoparticles for brain cancer	23
Current insights into drug-coated balloons for peripheral arterial disease	23
Critical review on the role of excipient properties in pharmaceutical powder-to-tablet continuous manufacturing	22
Potential bladder cancer therapeutic delivery systems: a recent update	22
3D printed dosage forms, where are we headed?	22
Long-acting HIV pre-exposure prophylaxis (PrEP) approaches: recent advances, emerging technologies, and development challenges	21
Carbohydrates based stimulus responsive nanocarriers for cancer-targeted chemotherapy: a review of current practices	21
Platelets for advanced drug delivery in cancer	21
A technology evaluation of the atypical use of a CPP-containing peptide in the formulation and performance of a clinical botulinum toxin product	21
Understanding the interaction forces between shield-triggered autoinjectors and skin: an in-depth noninvasive study	21
Targeted transport of biotherapeutics at the blood-brain barrier	20
Synthesis of a targeted, dual pH and redox-responsive nanoscale coordination polymer theranostic against metastatic breast cancer in vitro and in vivo	20
Evaluating the breadth of nucleic acid-based payloads delivered in lipid nanoparticles to establish fundamental differences in development	20
Dimeric ferulic acid conjugate as a prodrug for brain targeting after nasal administration of loaded solid lipid microparticles	20
Intramuscular injection of palmitic acid-conjugated Exendin-4 loaded multivesicular liposomes for long-acting and improving in-situ stability	20
Future applications of cyclic antimicrobial peptides in drug delivery	20
Laser microporation facilitates topical drug delivery: a comprehensive review about preclinical development and clinical application	20
An update on cell-penetrating peptides with intracellular organelle targeting	19
Metered dose inhalers in the transition to low GWP propellants: what we know and what is missing to make it happen	19
Lipid-based nanosystems for wound healing	19
Polyphosphoester cubosomes: introducing a novel drug delivery system	19
Is electroporation the key to drug delivery in drug-resistant cancers?	19
Pediatric inhalation therapy and the aerodynamic rationale for age-based aerosol sizes	19
Particle surface coating for dry powder inhaler formulations	18
Inhalation delivery of nucleic acid gene therapies in preclinical drug development	18
3D-printed solid oral dosage forms for mental and neurological disorders: recent advances and future perspectives	18
Preclinical evaluations of Norcantharidin liposome and emulsion hybrid delivery system with improved encapsulation efficiency and enhanced antitumor activity	18
Polymer-based thermoresponsive hydrogels for controlled drug delivery	17
Biphasic drug release from electrospun structures	17
Influence factors on and potential strategies to amplify receptor-mediated nanodrug delivery across the blood–brain barrier	17
Untethered shape-changing devices in the gastrointestinal tract	17

Topical drug delivery to the retina: obstacles and routes to success	17
Recent advances in antibacterial nanoformulations for endodontic applications	16
Microneedles for oral mucosal delivery – Current trends and perspective on future directions	16
Recent advances in drug delivery to the central nervous system by inhalation	16
Development and approval of novel injectables: enhancing therapeutic innovations	16
Opportunities for enteral drug delivery for neonates, infants, and toddlers: a critical exploration	16
An evolving perspective on novel modified release drug delivery systems for inhalational therapy	15
Dendrimer-mediated targeting of angiogenic biomarkers: therapeutic intervention against cancer	15
An interview with professor Dermot O’Toole by Zoe Kenney, commissioning editor	15
The engineering challenges and opportunities when designing potent ionizable materials for the delivery of ribonucleic acids	15
The impact of common pharmaceutical excipients on the gut microbiota	15
Sustained release of brimonidine from conjunctival sac insert to reduce intraocular pressure for glaucoma treatment	15
Targeting the gut microbiome to control drug pharmacomicrobiomics: the next frontier in oral drug delivery	14
Targeting cerebral diseases with enhanced delivery of therapeutic proteins across the blood-brain barrier	14
Redox chemical delivery system: an innovative strategy for the treatment of neurodegenerative diseases	14
GPP-TSAIII nanocomposite hydrogel-based photothermal ablation facilitates melanoma therapy	14
An update on the latest strategies in retinal drug delivery	14
Drug delivery improvements to enable a flexible care setting for monoclonal antibody medications in oncology - Analogue-based decision framework	14
Recent developments in nanofiber-based fast-disintegrating drug delivery systems	14
Inhaled antifungal therapy: benefits, challenges, and clinical applications	14
Smart design of patient-centric long-acting products: from preclinical to marketed pipeline trends and opportunities	14
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for the delivery of bioactives sourced from plants: part I – composition and production methods	14
Nano-drug delivery system of natural products for disease prevention and treatment	14
Subunit antigen delivery: emulsion and liposomal adjuvants for next-generation vaccines	13
Biodegradable nanoplatforms for antigen delivery: part II – nanoparticles, hydrogels, and microneedles for cancer immunotherapy	13
Doxorubicin-loaded graphene oxide nanocomposites in cancer medicine: stimuli-responsive carriers, co-delivery and suppressing resistance	13
Recent advances in erythrocyte membrane-camouflaged nanoparticles for the delivery of anti-cancer therapeutics	13
Recent advances in nanoformulation development of Ritonavir, a key protease inhibitor used in the treatment of HIV-AIDS	13
Biomaterials-assisted construction of neoantigen vaccines for personalized cancer immunotherapy	13
Breast cancer epidemiology, diagnostic barriers, and contemporary trends in breast nanotheranostics and mechanisms of targeting	13
Mucoadhesive drug delivery systems: a promising noninvasive approach to bioavailability enhancement. Part II: formulation considerations	13
Solid lipid nanoparticles: a promising tool for insulin delivery	13
Biopredictive tools for the development of injectable drug products	13
The current paradigm for biologic initiation: a confirmatory quantitative analysis of self-injection training practices	13
Advances in plasmonic-based MOF composites, their bio-applications, and perspectives in this field	13
Solid lipid nanoparticles and nanostructured lipid carrier-based nanotherapeutics for the treatment of psoriasis	13
Drug delivery systems for wound healing treatment of upper airway injury	12
The pursuit of linear dosage in pharmacy: reservoir-based drug delivery systems from macro to micro scale	12
Biomaterials-assisted cancer vaccine delivery: preclinical landscape, challenges, and opportunities	12
Development of an intranodal drug delivery system using a mouse model with lymphadenopathy: novel discoveries and clinical application	12
Advances in engineering and delivery strategies for cytokine immunotherapy	12
Bovine serum albumin nanoparticles: a promising platform for nasal drug delivery	12
Exploring space-energy matching via quantum-molecular mechanics modeling and breakage dynamics-energy dissipation via microhydrodynamic modeling to improve the screening efficiency of nanosuspension p	12
Next-generation viral nanoparticles for targeted delivery of therapeutics: Fundamentals, methods, biomedical applications, and challenges	12
Re-envisioning the design of nanomedicines: harnessing automation and artificial intelligence	12