Basic & Clinical Pharmacology & Toxicology

Article	Citations
Issue Information	224
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How does deprescribing (not) reduce mortality? A review of a meta‐analysis in community‐dwelling older adults casts uncertainty over claimed benefits	111
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Matrix metalloproteinases are associated with severity of disease among COVID‐19 patients: A possible pharmacological target	55
Artesunate alleviates intracerebral haemorrhage secondary injury by inducing ferroptosis in M1‐polarized microglia and suppressing inflammation through AMPK/mTORC1/GPX4 pathway	48
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Barriers and Facilitators to Pharmacist‐Led Deprescribing of Antihypertensives in Long‐Term Care: A Survey‐Based Study	37
Role of Inflammatory and Proresolving Mediators in Endothelial Dysfunction	23
Efficacy of fibroblast growth factor 21 in non‐alcoholic fatty liver disease in guinea pigs	23
Antioxidant, Antiinflammatory and Antiapoptotic Effects of Lycopene in Rats With Vancomycin‐Induced Nephrotoxicity	22
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Antibiotic treatment of community‐acquired pneumonia: A questionnaire survey in Danish general practice	20
Incidence in pharmacoepidemiology—Basic definitions and types of misclassification	20
Register‐based study on prescription renewal without the prescriber meeting the patient	19
Copper fabric improves the metabolic profile of obese mice: Potential role of the gut microbiota	19
Assessment of drug–drug interactions between moxonidine and antiepileptic drugs in the maximal electroshock seizure test in mice	19
Clinical predictors of nephrotoxicity associated with teicoplanin: Meta‐analysis and meta‐regression	18
Triangulation of pharmacoepidemiology and laboratory science to tackle otic quinolone safety	18
A two‐decade review of butane toxicity as a substance of abuse	17
Lithium and the risk of chronic kidney disease: A population‐based case–control study	17
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Possible opioid‐saving effect of cannabis‐based medicine using individual‐based data from the Norwegian Prescription Database	16
Medication use among the oldest old in the Faroe Islands—A national cross‐sectional study	16
Pregnane X receptor activation induces liver enlargement and regeneration and simultaneously promotes the metabolic activity of CYP3A1/2 and CYP2C6/11 in rats	15

Preclinical safety and biodistribution assessment of Ad‐KCNH2‐G628S administered via atrial painting in New Zealand white rabbits	15
Vitamin D and SARS‐CoV‐2	15
Decreased blood pressure with acute administration of quercetin in L‐NAME‐induced hypertensive rats	15
A characterization of patients with low soluble urokinase plasminogen activator receptor who died within 90 days of hospital discharge	15
Sapanisertib attenuates pulmonary fibrosis by modulating Wnt5a/mTOR signalling	14
The Patient Typology about deprescribing and medication‐related decisions: A quantitative exploration	14
The alleviatory effects of koumine on MSU‐induced gouty arthritis via the TLR4/NF‐κB/NLRP3 pathway	14
Methadone pharmacokinetics in opioid agonist treatment: Influencing factors and clinical implications	14
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The Incidence of Benzodiazepine and Benzodiazepine‐Related Drug Use in People With and Without Parkinson's Disease—A Nationwide Cohort Study	13
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Cytotoxicity, genotoxicity and mutagenicity of mixed ternary mononuclear Mg complex based on valproic acid with 1,10‐phenanthroline in Saccharomyces cerevisiae and V79 cells	13
Drug metabolism and drug transport of the 100 most prescribed oral drugs	13
Prescribing and deprescribing trends in schizophrenia: An overview of inpatients in Belgium and in the Canadian province of Québec	12
Role of cytochrome P450 2C8 genetic polymorphism and epoxygenase uncoupling in periodontal remodelling affecting orthodontic treatment	12
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Increased Mitochondrial Superoxide Level Is Partially Associated With Vemurafenib‐Induced Renal Tubular Toxicity	12
Fluvoxamine Inhibited NLRP3 and NF‐κB Inflammatory Pathways and Maintained Genital Functions by Ameliorating CD‐MPR, KISS‐1, AQP4 and Claudin‐1 Expressions	12
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Risk of kidney injury in patients on concomitant oral vancomycin and piperacillin‐tazobactam: Analysis of the pharmacovigilance database in Japan	12
Metabolism studies of 4′Cl‐CUMYL‐PINACA, 4′F‐CUMYL‐5F‐PINACA and 4′F‐CUMYL‐5F‐PICA using human hepatocytes and LC‐QTOF‐MS analysis	11
Chronic mercury exposure induces oxidative stress in female rats by endothelial nitric oxide synthase uncoupling and cyclooxygenase‐2 activation, without affecting oestrogen receptor function	11
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ChatGPT: First glance from a perspective of clinical pharmacology	11
Effects of Zuojin Pill (Rhizoma CoptidisandFructus Evodiaepreparation) on the pharmacokinetics and side effects of venlafaxine in humans	11
New Monitoring Recommendations for Digoxin During the Last Decade Are Associated With Decreased Serum Digoxin Concentrations in Patient Samples	11
Copper: From enigma to therapeutic target for neurological disorder	11
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Further perspectives on statin use in patients with chronic kidney disease	11
Liquiritigenin‐Rich Hydroalcoholic Extract of Brazilian Red Propolis Reduces Dyskinesia Induced by 3,4‐ Dihydroxyphenylalanine in Hemiparkinsonian Rats	11
Drugs targeting APOE4 that regulate beta‐amyloid aggregation in the brain: Therapeutic potential for Alzheimer's disease	11
Leaky lessons learned: Efflux prone dopamine transporter variant reveals sex and circuit specific contributions of D2 receptor signalling to neuropsychiatric disease	11
Effects of organic chemicals from diesel exhaust particles on adipocytes differentiated from human mesenchymal stem cells	11
Potential drug‐drug interactions in acute poisonings managed in the intensive care unit: Occurrence, risk factors and relationship to patient severity on admission	11
The stimulant cathine from Khat causes tachycardia indirectly in the rat	11
Exosomal lncRNA HOTAIR promotes osteoclast differentiation by targeting TGF‐β/PTHrP/RANKL pathway	10
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The Role of Hydroxychloroquine in the Management of Rheumatic Disorders: A Comprehensive Review	10
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Ameliorative Role of β‐Caryophyllene on Antioxidant Biomarkers in a Paroxetine‐Induced Model of Male Sexual Dysfunction	9
Role of bradykinin and prostaglandin EP4 receptors in regulating TRPV1 channel sensitization in rat dorsal root ganglion neurons	9
First‐in‐human study with ACT‐1014‐6470, a novel oral complement factor 5a receptor 1 (C5aR1) antagonist, supported by pharmacokinetic predictions from animals to patients	9
Inappropriate polypharmacy management versus deprescribing: A review on their relationship	9
Review of the Delay of Chronic Kidney Disease Progression by Wuling San on Improving Renal Fibrosis	9
Letter from the editor	9
Optimizing autophagy modulation for enhanced TRAIL‐mediated therapy: Unveiling the superiority of late‐stage inhibition over early‐stage inhibition to overcome therapy resistance in cancer	9
Effects of GLP‐1 Receptor Agonists in Alcohol Use Disorder	9

Assessment of Rivaroxaban Plasma Concentration Using Chromogenic Anti‐Xa Assays and UHPLC–MS/MS in Chinese Patients With Atrial Fibrillation	9
The state of deprescribing research: How did we get here?	9
Effects of quercetin on ovarian function and regulation of the ovarian PI3K/Akt/FoxO3a signalling pathway and oxidative stress in a rat model of cyclophosphamide‐induced premature ovarian failure	9
BCPT 2024 Prizes and Awards	9
Development of an Artificial Intelligence Powered Medication Risk Score Calculator Application	9
Effect of dexmedetomidine on oxytocin‐induced uterine contraction during optimal caesarean section anaesthesia	9
Pro‐inflammatory cytokines/chemokines, TNF‐α, IL‐6 and MCP‐1, as biomarkers for the nephro‐ and pneumoprotective effect of silibinin after hepatic ischemia/reperfusion: Confirmation by immunohistochem	9
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Individual susceptibility has a major impact on strong association between oxidative stress, defence systems and Parkinson's disease	8
Somatostatin receptor ligands suppressed proliferation and lipogenesis in 3T3‐L1 preadipocytes	8
Changes in oral corticosteroid use in asthma treatment—A 20‐year Danish nationwide drug utilisation study	8
Deprescribing in primary care without deterioration of health‐related outcomes: A real‐life, quality improvement project	8
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Persistence to statin treatment: A cohort study in Lithuania	8
Dose safety and pharmacodynamics of subcutaneous bupivacaine in a novel extended‐release microparticle formulation: A phase 1, dose‐ascending study in male volunteers	8
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In vitro effect of hyoscine‐N‐butyl bromide and diclofenac sodium in human tuba uterina	8
Four weeks SGLT2 inhibition improves beta cell function and glucose tolerance without affecting muscle free fatty acid or glucose uptake in subjects with type 2 diabetes	8
Correction to Involvement of H2S, NO and BDNF‐TrkB signalling pathway in the protective effects of simvastatin against pentylenetetrazole‐induced kindling and cognitive impairments in mice	8
Advancing deprescribing: Learnings from the first international conference on deprescribing	8
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‘This Is My Decision’: A Qualitative Study of Individuals' Perspectives on Use of Semaglutide for Weight Loss	7
Mechanistic insights into the pathogenesis of microtubule‐targeting agent‐induced peripheral neuropathy from pharmacogenetic and functional studies	7
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Efficacy of weekly versus daily cholecalciferol for repleting serum vitamin D (25(OH)D) deficiency: A systematic review and meta‐analysis of randomized controlled trials	7
Development of a Deprescribing Intervention for Proton Pump Inhibitors in Primary Care: A Co‐Design Approach With General Practitioners and Patients	7
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Making it happen: Development of an interprofessional deprescribing education programme	7
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Effects of rifampicin on porphyrin metabolism in healthy volunteers	7
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Disease activity and therapeutic drug monitoring of polyglutamates of methotrexate after daily or weekly administration of low‐dose methotrexate in patients recently diagnosed with rheumatoid arthriti	7
The Molecular and Clinical Impact of Atorvastatin Exposure on Paclitaxel Neurotoxicity in Sensory Neurons and Cancer Patients	7
Erratum	7
Gentiopicroside Attenuated Dopaminergic Neurodegeneration via Inhibiting Neuroinflammatory Responses and Ferroptosis in Experimental Models of Parkinson's Disease	7
Berberine regulates pulmonary inflammatory microenvironment and decreases collagen deposition in response to bleomycin‐induced pulmonary fibrosis in mice	7
High Throughput Pharmacovigilance Screening for Roflumilast Adverse Effects in Real‐World Settings: A Sequence Symmetry Analysis	6
A review on the new age methodologies for early detection of Alzheimer's and Parkinson's disease	6
Growth differentiation factor 15 is dispensable for acetaminophen‐induced liver injury in mice	6
Pharmacokinetics of free and total mycophenolic acid in paediatric and adult renal transplant recipients: Exploratory analysis of the effects of clinical factors and gene variants	6
Downregulation of GPR160 inhibits the progression of glioma through suppressing epithelial to mesenchymal transition (EMT) biomarkers	6
Corrigendum	6
Multiple regulation and targeting effects of borneol in the neurovascular unit in neurodegenerative diseases	6
Application of Artificial Intelligence in the Development of Traditional Chinese Medicine	6
Exploratory pharmacovigilance with machine learning in big patient data: A focused scoping review	6
Deaths caused by medication in persons not using illicit narcotic drugs: An autopsy study from Western Denmark	6
Dementia and neurodegenerative diseases: What is known and what is promising at the cellular and molecular level	6
Effect of stearyl alcohol on imiquimod‐induced psoriasis‐like skin inflammation in mice	6
Studies on the mode of action of synthetic diindolylmethane derivatives against triple negative breast cancer cells	6
The effectiveness and safety of botulinum toxin injections for managing motor disorders of patients with Parkinson's disease: A meta‐analysis of randomized controlled trials	6
Correction to ‘β‐LAPachone Ameliorates Doxorubicin‐Induced Cardiotoxicity via Regulating Autophagy and Nrf2 Signalling Pathways in Mice’	6
The Effects of Drugs on CYP3A Enzyme Activity and Protein Expression Through Ubiquitination Modification Regulation	6
Plasma NGAL, suPAR, KIM‐1 and GDF‐15 for Improving Glomerular Filtration Rate Estimation in Older Hospitalized Patients	6
Special Collection: Mechanisms of Vasodilatation Endothelium‐Dependent Hyperpolarization (MOVD/EDH2024)	6
Paroxetine alleviates ulcerative colitis in mice via restoring intestinal microbiota homeostasis and metabolism	6
Issue Information	6
Toxicity and therapy outcome associations in LIG3, SLCO1B3, ABCB1, OPRM1 and GSTP1 in high‐grade serous ovarian cancer	6
Foetal Exposure to Phthalates and Endocrine Effects on the Leydig Cell	5
Eugenol Alleviates Cerebral Ischemia–Reperfusion Injury in Mice by Promoting the Phagocytosis of Microglia via Up‐Regulating Tripartite Motif Protein 59	5
Categorization of deprescribing communication tools: A scoping review	5
α‐Lipoic acid up‐regulates gene expression but reduces protein levels of fibroblast growth factor 21 in HepG2 cells	5
CYP3A4*22 and bleeding risk in ticagrelor users	5
Limited sampling approach for model‐informed precision dosing of daptomycin to rapidly achieving the target area under the concentration‐time curve: A simulation study	5
Study of the mechanism underlying the role of PINK1/Parkin in the formic acid‐induced autophagy of PC12 cells	5
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Multi‐Target Renal Protection of Wine‐Processed Polygonatum sibiricum Against Cisplatin‐Induced Nephrotoxicity: Integrated Phytochemistry, Network Pharmacology and Experimental Valid	5
Therapeutic benefit of melatonin in 5‐fluorouracil‐induced renal and hepatic injury	5
The Pathobiology of Cerebrovascular Lesions in CADASIL Small Vessel Disease	5
Emergency Department Visits due to Medication Overdose in a Finnish University Hospital	5
Welcome to Basic & Clinical Pharmacology & Toxicology 2024	5
Adverse effects of an aldosterone synthase (CYP11B2) inhibitor, fadrozole (FAD286), on inflamed rat colon	5
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Gastroprotective effect of sumatriptan against indomethacin‐, stress‐ and ethanol‐induced gastric damage in male rats: Possible modulatory role of 5‐hydroxytryptamine 1B/1D receptors and pro‐inflammat	5
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Initiation of Anticoagulants During the COVID‐19 Pandemic in Sweden: An Interrupted Time Series Analysis	5

LW‐AFC Protects Against Neurological and Neuropsychiatric Effects of SARS‐CoV‐2 Spike Protein in Mice	5
The role of decision tree and machine learning models for outcome prediction of bupropion exposure: A nationwide analysis of more than 14 000 patients in the United States	5
Ten deprescribing articles you should know about: A guide for newcomers to the field	5
Traditional Chinese Medicine for Inhibiting Ferroptosis in Ischemic‐Related Diseases	5
Healthcare Providers' Perspectives on Antidepressant Discontinuation: A Focus Group Study	5
Bruceine A Inhibits Cell Proliferation by Targeting the USP13/PARP1 Signalling Pathway in Multiple Myeloma	5
Vancomycin audit in the paediatric population: Patterns of use and appropriateness of therapeutic drug monitoring	5
Antitumour effect of odoroside A and its derivative on human leukaemia cells through the ROS/JNK pathway	5
Disease‐modifying therapies in multiple sclerosis: A focused review of rituximab	5
Atenolol and mortality events in patients with chronic kidney disease: Analysis of data from the Japanese Adverse Drug Event Report database	5
Triptolide alleviates collagen‐induced arthritis in mice by modulating Treg/Th17 imbalance through the JAK/PTEN‐STAT3 pathway	5
Biomarkers of Parkinson's disease in perspective of early diagnosis and translation of neurotrophic therapies	5
Issue Information	5
Association between patient attitudes towards deprescribing and subsequent prescription changes	5
Phase I clinical trial evaluating the safety, tolerance, pharmacokinetics and pharmacodynamics of HSK21542 injection in healthy volunteers	4
DPYD genotyping and dihydropyrimidine dehydrogenase (DPD) phenotyping in clinical oncology. A clinically focused minireview	4
Should high‐dose N‐acetylcysteine be given in cases of massive paracetamol overdoses: A narrative review	4
Sildenafil attenuates oxidative stress and endothelial dysfunction in lead‐induced hypertension	4
Benchmark dose and the adverse effects of exposure to pendimethalin at low dose in female rats	4
Structure–activity relationship of GPR15L peptide analogues and investigation of their interaction with the GPR15 receptor	4
Safety evaluation of adenosine, lidocaine and magnesium (ALM) intranasal therapy toward human nasal epithelial cells in vitro	4
Cyclopeptide mushroom poisoning: A retrospective series of 204 patients	4
Differences in the Inflammatory Response and Corticoid Responsiveness of Human Lung Macrophages and Parenchymal Explants Exposed to Cigarette Smoke Extracts	4
Comparing different postoperative sedation strategies for patients in the intensive care unit after cardiac surgery: A systematic review of randomized controlled trials and network meta‐analysis	4
Retrospective identification of new psychoactive substances in patient samples submitted for clinical drug analysis	4
Letter from the editor	4
Long‐Term Safety and Efficacy of AAV9 Vectors Expressing Human SMN1 Gene: A Preclinical Study	4
Dimetindene—Is the minimum toxic dose for children too strict?	4
The BCPT young researcher Nordic Prize 2022 goes to Associate Professor Tore Bjerregaard Stage	4
The effects of cannabidiol against Methotrexate‐induced lung damage	4
Behavioural interaction of pyrazoloquinolinone positive allosteric modulators at α6GABAA receptors and diazepam in rats: Anti‐diazepam‐induced ataxia action as a structure‐dependent feature	4
Carnosol attenuated atrophy of C2C12 myotubes induced by tumour‐derived exosomal miR‐183‐5p through inhibiting Smad3 pathway activation and keeping mitochondrial respiration	4
Models of Endocrine‐Disrupting Effects: Human Placental Steroidogenesis	4
Olanzapine‐associated dose‐dependent alterations for weight and metabolic parameters in a prospective cohort	4
The Effect of ABCB1 Polymorphisms on the Efficacy of Antidepressants	4
The role of peroxisome proliferator‐activated receptors in the regulation of bile acid metabolism	4
Retraction	4
Coronary Microvascular Dysfunction in Ischaemic Heart Disease: Lessons From Large Animal Models	4
Per‐ and polyfluoroalkyl substances and cardiometabolic diseases: A review	4
Gender balance in the editorial room: BCPT as model journal?	4
Eugenol delays the onset of ouabain‐induced ventricular cardiac arrhythmias in guinea pigs	4
Effect of Acute Exposure of Swiss Mice to Chlorogenic Acid	4
Therapeutic applicability of cannabidiol and other phytocannabinoids in epilepsy, multiple sclerosis and Parkinson's disease and in comorbidity with psychiatric disorders	4
Efficacy and Safety of Clopidogrel With and Without a Proton Pump Inhibitor: A Systematic Review and Meta‐Analysis	4
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Ribavirin inhibits cell proliferation and metastasis and prolongs survival in soft tissue sarcomas by downregulating both protein arginine methyltransferases 1 and 5	4
Investigating the P53‐dependent anti‐cancer effect of ibutamoren in human cancer cell lines	4
Optimal dosing of gliclazide—A model‐based approach	4
The protective effect of solidagenone from Solidago chilensis Meyen in a mouse model of airway inflammation	4
Application of physiologically based pharmacokinetic modelling for the prediction of drug–drug interactions involving anlotinib as a perpetrator of cytochrome P450 enzymes	4
“Biosimilar, so it looks alike, but what does it mean?” A qualitative study of Danish patients' perceptions of biosimilars	4
Transfer of cetirizine/levocetirizine into human breast milk and estimation of drug exposure to infants through breastfeeding: A human lactation study from the ConcePTION project	4
Describing long‐term opioid use utilizing Nordic prescription registers—A Norwegian example	4
Poisonings With Opioids and Benzodiazepines in Denmark: A Retrospective Study From the Danish Poison Information Centre	4
Binder jetting 3D printing in fabricating pharmaceutical solid products for precision medicine	4
Emerging Molecular Targets in Neurodegenerative Disorders: New Avenues for Therapeutic Intervention	4
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Review of clinical pharmacokinetics and pharmacodynamics of clonidine as an adjunct to opioids in palliative care	4
Parental cigarette smoking before and during pregnancy in a cohort of 21 472 pregnancies	4
Direct oral anticoagulant concentrations and adherence in stroke patients	4
Blood Pressure–Lowering Effects of Aldosterone Synthase Inhibitors—A Systematic Review	4
A dose‐related positive effect of inhaled simvastatin‐loaded PLGA nanoparticles on paraquat‐induced pulmonary fibrosis in rats	3
Monitoring paxillin in astrocytes reveals the significance of the adhesion G protein coupled receptor VLGR1/ADGRV1 for focal adhesion assembly	3
Survey content validation evaluating the dissemination and implementation of deprescribing guidelines	3
The Potential Ability of Betulinic Acid to Prevent Experimentally Induced Acute Pancreatitis in Rats	3
Correction to ‘Medication use among the oldest old in the Faroe Islands—A national cross‐sectional study’	3
Diallyl trisulfide alleviates dextran sulphate sodium‐induced colitis in mice by inhibiting NLRP3 inflammasome activation via ROS/Trx‐1 pathway	3
Fentanyl overdose: Temporal effects and prognostic factors in SKH1 mice	3
Issue Information	3
Pregnancy Outcomes After Semaglutide Exposure	3
Non‐recovery of vancomycin‐associated nephrotoxicity is related to worsening survival outcomes: Combined retrospective analyses of two real‐world databases	3
Associate Professor Morten Schmidt, Denmark, is the BCPT Young Researcher Nordic Prize winner in Basic & Clinical Pharmacology & Toxicology for 2021	3
Medication management in Danish home health care: Mapping of tasks and time consumption	3
Changes in diaphragm contractility in cigarette smoking‐exposed and smoking cessation rats are associated with alterations in mitochondrial morphology and homeostasis	3
Association Between CYP2D6 Genotypes and Serum Concentrations of Mirtazapine and Mianserin	3
Trends in medication use at the onset of and during the COVID‐19 pandemic in the Republic of Ireland: An interrupted time series study	3
How Is Psychotropic Use for Challenging Behaviour in People With Intellectual Disability Understood by Stakeholders? A Concept Analysis Using Rodgers' Evolutionary Approach	3
Maternal Demographic Patterns in Medication use During Pregnancy: A Nationwide Register Study	3
A study of the genotoxicity, fertility and early embryonic development toxicity of rotigotine behenate extended‐release microspheres	3
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Scientific program	3
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Sodium bicarbonate reverts electrophysiologic cardiotoxicity of ropivacaine faster than lipid emulsions in a porcine model	3
Development and validation of an automated microfluidic perfusion platform for parallelized screening of compounds in vitro	3
Diloxanide in amoebiasis management: Unravelling the mechanism of action and effectiveness	3
Computational and structural insights into the pre‐ and post‐hydrolysis states of bovine multidrug resistance‐associated protein 1	3
Gastroprotective effect of topiramate on indomethacin‐induced peptic ulcer in rats: Biochemical and histological analyses	3
The BCPT Nordic Prize 2022 goes to Professor Kim Brøsen	3
Exploring the role of oxidative stress and the effect of N‐acetylcysteine in thiopurine‐induced liver injury in inflammatory bowel disease: A randomized crossover pilot study	3
Population kinetic–pharmacodynamic analysis of serum potassium in patients receiving sulfamethoxazole/trimethoprim	3
Professor Henrik Enghusen Poulsen, Denmark, is the BCPT Nordic Prize winner in Basic & Clinical Pharmacology & Toxicology for 2021	3
Development of a quick guide for assessment of the most frequently used renal risk medication in Danish hospitals and primary care	3
Evaluation and validation of chemotherapy‐specific diarrhoea and histopathology in rats	3
High anticholinergic burden at admission associated with in‐hospital mortality in older patients: A comparison of 19 different anticholinergic burden scales	3