Basic & Clinical Pharmacology & Toxicology

Article	Citations
Deprescribing and medicines optimisation, two sides of the same coin? Considerations for design of interventional studies	160
Generation and initial characterization of mice lacking full‐length BAI3 (ADGRB3) expression	150
Sacubitril/valsartan, sodium‐glucose cotransporter 2 inhibitors and vericiguat for congestive heart failure therapy	89
	57
How does deprescribing (not) reduce mortality? A review of a meta‐analysis in community‐dwelling older adults casts uncertainty over claimed benefits	47
Paroxetine alleviates ulcerative colitis in mice via restoring intestinal microbiota homeostasis and metabolism	44
	36
Serum Ethanol Concentrations in Relation to Sex and Age in Patients Admitted to a Large Emergency Department During 2015–2020	35
Long‐term taurine supplementation regulates brain mitochondrial dynamics in mice	32
Dapagliflozin prevents reproductive damage caused by acute systemic inflammation through antioxidant, anti‐inflammatory, and antiapoptotic mechanisms	27
Dementia and neurodegenerative diseases: What is known and what is promising at the cellular and molecular level	24
Perineuronal nets as regulators of parvalbumin interneuron function: Factors implicated in their formation and degradation	21
Trends in antidote utilization at a tertiary care hospital in Saudi Arabia: A 6‐year retrospective study	18
Issue Information	18
Clinical predictors of nephrotoxicity associated with teicoplanin: Meta‐analysis and meta‐regression	18
In Vivo Investigation of the Effects of Nonylphenol on the Pituitary–Adrenal Axis and Pineal Gland in Male Rats	18
Efficacy of fibroblast growth factor 21 in non‐alcoholic fatty liver disease in guinea pigs	17
	15
Antibiotic treatment of community‐acquired pneumonia: A questionnaire survey in Danish general practice	15
The long non‐coding RNA maternally expressed 3‐micorRNA‐15a‐5p axis is modulated by melatonin and prevents nucleus pulposus cell inflammation and apoptosis	15
The risk of fragility fractures following initiation of gabapentin and pregabalin—A Danish, nationwide, high‐dimensional propensity score‐matched cohort study	14
Issue Information	14
Cucurbitacin E ameliorates airway remodelling by inhibiting nerve growth factor expression in nicotine‐treated bronchial epithelial cells and mice: The key role of let‐7c‐5p up‐regulated expression	14
Lithium use and the risk of chronic kidney disease	14
Metformin serum concentrations during pregnancy and post partum – A clinical study in patients with polycystic ovary syndrome	13

Sodium bicarbonate reverts electrophysiologic cardiotoxicity of ropivacaine faster than lipid emulsions in a porcine model	13
Sodium para‐aminosalicylic acid attenuates combined manganese/iron‐induced cortical synaptic damage in rats	13
	13
Incidence in pharmacoepidemiology: A conceptual framework for incidence of a single substance or group of substances with statins as an example	12
Issue Information	11
Triangulation of pharmacoepidemiology and laboratory science to tackle otic quinolone safety	11
Issue Information	11
	11
	11
The antianginal ranolazine fails to improve glycaemia in obese liver‐specific pyruvate dehydrogenase deficient male mice	11
Methylophiopogonanone A is a naturally occurring broad‐spectrum inhibitor against human UDP‐glucuronosyltransferases: Inhibition behaviours and implication in herb‐drug interactions	11
Fentanyl overdose: Temporal effects and prognostic factors in SKH1 mice	10
Professor Henrik Enghusen Poulsen, Denmark, is the BCPT Nordic Prize winner in Basic & Clinical Pharmacology & Toxicology for 2021	10
Claus Bræstrup 17 January 1945 to 7 February 2023	10
Issue Information	10
3‐Quinuclidinyl benzilate (agent BZ) toxicokinetics in rats	10
Peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha protects a fibrotic liver from partial hepatectomy‐induced advanced liver injury through regulating cell cycle arrest	10
A dose‐related positive effect of inhaled simvastatin‐loaded PLGA nanoparticles on paraquat‐induced pulmonary fibrosis in rats	10
Involvement of the effect of renal hypoperfusion medications on vancomycin trough concentration: A secondary analysis using a retrospective observational data	10
Issue Information	10
Issue Information	10
Falsely low phosphatidylethanol may be associated with biomarkers of haemolytic disease	10
	9
Population kinetic–pharmacodynamic analysis of serum potassium in patients receiving sulfamethoxazole/trimethoprim	9
	9
Botulinum toxin A promotes the transdifferentiation of primary keloid myofibroblasts into adipocyte‐like cells	9
A five‐pronged critique of ‘Serotonin syndrome—A focused review’	9
Short‐term mortality following tramadol poisonings in Denmark	9
Status of treatment strategies for Hutchinson–Gilford progeria syndrome with a focus on prelamin: A posttranslational modification	9
Non‐recovery of vancomycin‐associated nephrotoxicity is related to worsening survival outcomes: Combined retrospective analyses of two real‐world databases	9
Incidence in pharmacoepidemiology—Basic definitions and types of misclassification	9
Diallyl trisulfide alleviates dextran sulphate sodium‐induced colitis in mice by inhibiting NLRP3 inflammasome activation via ROS/Trx‐1 pathway	9
Issue Information	9
	8
Probiotic bacteria alleviate chlorpyrifos‐induced rat testicular and renal toxicity: A possible mechanism based on antioxidant and anti‐inflammatory activity	8
Assessment of drug–drug interactions between moxonidine and antiepileptic drugs in the maximal electroshock seizure test in mice	8
Retrospective analysis of clinical characteristics of and treatment strategies for patients with long‐acting anticoagulant rodenticide poisoning	8
Trough plasma nevirapine levels, immunologic and virologic responses in composite CYP2B6*6/*18 HIV‐infected adult Nigerian patients	8
Issue Information	8
Erratum	8
Issue Information	8
COMMITTEES	8
Issue Information	8
Issue Information	8
Round tables	8
Cerebral microbleeds in the poisoned patient: An observational magnetic resonance imaging study	8
Matrix metalloproteinases are associated with severity of disease among COVID‐19 patients: A possible pharmacological target	7
Issue Information	7
Population pharmacokinetic–pharmacodynamic model of subcutaneous bupivacaine in a novel extended‐release microparticle formulation	7
Summarizing studies using constitutive genetic deficiency to investigate behavioural influences of uptake 2 monoamine transporters	7

Exploring the role of oxidative stress and the effect of N‐acetylcysteine in thiopurine‐induced liver injury in inflammatory bowel disease: A randomized crossover pilot study	7
The human LAT1–4F2hc (SLC7A5–SLC3A2) transporter complex: Physiological and pathophysiological implications	7
	7
Pharmacogenetic testing to guide therapeutic decision‐making and improve outcomes for children undergoing anthracycline‐based chemotherapy	7
Issue Information	7
Classification of acute poisoning exposures with machine learning models derived from the National Poison Data System	7
Issue Information	7
A study of the genotoxicity, fertility and early embryonic development toxicity of rotigotine behenate extended‐release microspheres	7
Decision tree outcome prediction of acute acetaminophen exposure in the United States: A study of 30,000 cases from the National Poison Data System	6
Development of a quick guide for assessment of the most frequently used renal risk medication in Danish hospitals and primary care	6
Issue Information	6
Lithium and the risk of chronic kidney disease: A population‐based case–control study	6
Effects of rifampicin on porphyrin metabolism in healthy volunteers	6
Issue Information	6
Population pharmacokinetics of eptinezumab in paediatric patients with migraine and dose selection for phase 3 paediatric migraine studies	6
Streptozotocin‐induced diabetes in rats modifies the role D2, D3and D4dopamine receptors play in cardiac sympathetic inhibition	6
N‐acetylcysteine as a potentially safe adjuvant in the treatment of neurotoxicity due to pirimiphos‐methyl poisoning	6
	6
Use of drugs with pharmacogenomics (PGx)‐based dosing guidelines in a Danish cohort of persons with chronic kidney disease, both on dialysis and not on dialysis: Perspectives for prescribing optimizat	6
Register‐based study on prescription renewal without the prescriber meeting the patient	6
Transient receptor potential channels as an emerging target for the treatment of Alzheimer's disease: Unravelling the potential of pharmacological interventions	6
	6
	5
The role of ATP‐binding cassette transporter G1 (ABCG1) in Alzheimer's disease: A review of the mechanisms	5
Understanding the Importance of the Small Artery Media–Lumen Ratio: Past and Present	5
Author index	5
Targeting of cancer cell death mechanisms by curcumin: Implications to cancer therapy	5
Fingolimod ameliorates acetic acid‐induced ulcerative colitis: An insight into its modulatory impact on pro/anti‐inflammatory cytokines and AKT/mTOR signalling	5
Efficacy of weekly versus daily cholecalciferol for repleting serum vitamin D (25(OH)D) deficiency: A systematic review and meta‐analysis of randomized controlled trials	5
Multiple regulation and targeting effects of borneol in the neurovascular unit in neurodegenerative diseases	5
Methamphetamine induces a low dopamine transporter expressing state without altering the total number of peripheral immune cells	5
Associate Professor Morten Schmidt, Denmark, is the BCPT Young Researcher Nordic Prize winner in Basic & Clinical Pharmacology & Toxicology for 2021	5
Risk of muscle toxicity events for daptomycin with and without statins: Analysis of the Japanese Adverse Event Report database	5
Issue Information	5
Association between patient attitudes towards deprescribing and subsequent prescription changes	5
Possible opioid‐saving effect of cannabis‐based medicine using individual‐based data from the Norwegian Prescription Database	5
Berberine regulates pulmonary inflammatory microenvironment and decreases collagen deposition in response to bleomycin‐induced pulmonary fibrosis in mice	5
Plasma NGAL, suPAR, KIM‐1 and GDF‐15 for Improving Glomerular Filtration Rate Estimation in Older Hospitalized Patients	5
	5
Interaction alerts: A comparison of classifications and recommendations for clinical management between Janusmed and three other knowledge resources	5
Free‐of‐charge dispensing of antipsychotics for schizophrenia in Denmark: Impact on the nationwide prescription registry and redemption of somatic medications	5
Home pharmacological therapy in early COVID‐19 to prevent hospitalization and reduce mortality: Time for a suitable proposal	5
High anticholinergic burden at admission associated with in‐hospital mortality in older patients: A comparison of 19 different anticholinergic burden scales	5
Downregulation of GPR160 inhibits the progression of glioma through suppressing epithelial to mesenchymal transition (EMT) biomarkers	5
Role of Inflammatory and Proresolving Mediators in Endothelial Dysfunction	5
Effect of stearyl alcohol on imiquimod‐induced psoriasis‐like skin inflammation in mice	5
Prevalence, associated factors and level of dependence of substance use among urban secondary school students, Benin	5
Medication management in Danish home health care: Mapping of tasks and time consumption	5
The effectiveness and safety of botulinum toxin injections for managing motor disorders of patients with Parkinson's disease: A meta‐analysis of randomized controlled trials	5
The glucocorticoid dexamethasone alleviates allergic inflammation through a mitogen‐activated protein kinase phosphatase‐1‐dependent mechanism in mice	5
Maternal Demographic Patterns in Medication use During Pregnancy: A Nationwide Register Study	5
Issue Information	5
Artesunate alleviates intracerebral haemorrhage secondary injury by inducing ferroptosis in M1‐polarized microglia and suppressing inflammation through AMPK/mTORC1/GPX4 pathway	5
A two‐decade review of butane toxicity as a substance of abuse	5
IL‐4 promotes chondrogenesis of bone marrow mesenchymal stem cells and blockade of IL‐4Rα retards the endochondral ossification during rat embryonic bone development	5
Contribution of membrane transporters to chemotherapy‐induced cardiotoxicity	5
Copper fabric improves the metabolic profile of obese mice: Potential role of the gut microbiota	5
Preclinical Evidence for a Drug–Drug Interaction Between Cannabinol and Melatonin	5
Bortezomib inhibits hepatocellular carcinoma via the Hippo‐Yes‐associated protein signalling pathway	5
No adverse effects on periarticular tissue by intra‐articular vitamin D analogue calcipotriol in a reduced‐dose zymosan‐induced arthritis model in rats	5
	5
The BCPT Nordic Prize 2022 goes to Professor Kim Brøsen	4
Rifampicin induces the bone form of alkaline phosphatase in humans	4
The use of cerium oxide nanoparticles in liver disorders: A double‐sided coin?	4
Doses, serum concentrations and diagnoses of Norwegian quetiapine users 2001–2019 in a therapeutic drug monitoring material	4
A characterization of patients with low soluble urokinase plasminogen activator receptor who died within 90 days of hospital discharge	4
Correction to “The Protective Effect of Modafinil on Vincristine‐Induced Peripheral Neuropathy in Rats: A Possible Role for TRPA1 Receptors”	4
Ten deprescribing articles you should know about: A guide for newcomers to the field	4
Vitamin D and SARS‐CoV‐2	4
Sodium‐glucose co‐transporter‐2 inhibitors in heart failure with reduced ejection fraction: Current evidence and future perspectives	4
Perspectives on medication safety from vulnerable older migrants and their relatives—A qualitative explorative study	4
	4
Therapeutic benefit of melatonin in 5‐fluorouracil‐induced renal and hepatic injury	4
Adhesion G protein‐coupled receptor's structure, function and role in biology—Status from the 10th adhesion GPCR workshop in Copenhagen, 2022	4
In vivo antidiabetic activity of nimesulide due to inhibition of amino acid transport	4
Lower tacrolimus time in therapeutic range is associated with inferior outcomes in adult liver transplant recipients	4
Pharmacokinetics of free and total mycophenolic acid in paediatric and adult renal transplant recipients: Exploratory analysis of the effects of clinical factors and gene variants	4
	4
Bioguided isolation of a selective compound from Calea phyllolepis leaves against breast cancer cells	4
Changes in diaphragm contractility in cigarette smoking‐exposed and smoking cessation rats are associated with alterations in mitochondrial morphology and homeostasis	4

	4
Differential vasodilator effect of Dioclea rostrata lectin in conductance and resistance arteries: Mechanisms and glycoconjugate binding relationships	4
The effect of first‐line antituberculosis drugs on the methemoglobin level among patients in treatment for pulmonary tuberculosis: A prospective study	4
Impact of steroid hormone levels on estradiol‐mediated regulation of cytochrome P450 2B6 compared to 1B1 in breast cancer cells	4
Monitoring paxillin in astrocytes reveals the significance of the adhesion G protein coupled receptor VLGR1/ADGRV1 for focal adhesion assembly	4
Correction to ‘Medication use among the oldest old in the Faroe Islands—A national cross‐sectional study’	4
Basic & Clinical Pharmacology & Toxicology wishes to thank the following scientists, who have acted as reviewers during 2021–2022	4
Impact of combining vancomycin with proton pump inhibitors on the incidence of acute kidney injury	4
Are there safety concerns for frequently repeated dosages of intravenous irons?	4
Dr. Olli Kärkkäinen has been awarded the BCPT Young Researcher Nordic Prize 2023	4
Issue Information	4
Preclinical safety and biodistribution assessment of Ad‐KCNH2‐G628S administered via atrial painting in New Zealand white rabbits	3
SLCO1B1 and ABCG2 genotype‐informed phenotypes are related to variation in ramipril exposure	3
Medication use among the oldest old in the Faroe Islands—A national cross‐sectional study	3
Gossypin Ameliorates Collagen‐Induced Arthritic Rats by Inhibiting Angiogenesis, Inflammation and Oxidative Stress	3
Expression of Concern	3
Pregnane X receptor activation induces liver enlargement and regeneration and simultaneously promotes the metabolic activity of CYP3A1/2 and CYP2C6/11 in rats	3
Studies on the mode of action of synthetic diindolylmethane derivatives against triple negative breast cancer cells	3
Corrigendum	3
What participants are told about receiving trial results when they consent to participate in a trial	3
Survey content validation evaluating the dissemination and implementation of deprescribing guidelines	3
Gastroprotective effect of topiramate on indomethacin‐induced peptic ulcer in rats: Biochemical and histological analyses	3
Toxicity and therapy outcome associations in LIG3, SLCO1B3, ABCB1, OPRM1 and GSTP1 in high‐grade serous ovarian cancer	3
Re‐routing GPR56 signalling using Gα12/13 G protein chimeras	3
Renin–angiotensin system in intestinal inflammation—Angiotensin inhibitors to treat inflammatory bowel diseases?	3
Computational and structural insights into the pre‐ and post‐hydrolysis states of bovine multidrug resistance‐associated protein 1	3
Growth differentiation factor 15 is dispensable for acetaminophen‐induced liver injury in mice	3
Addressing Improper Medicine Storage Practices: Commentary on Louhisalmi et  al.'s Study	3
Cytotoxicity, genotoxicity and mutagenicity of mixed ternary mononuclear Mg complex based on valproic acid with 1,10‐phenanthroline in Saccharomyces cerevisiae and V79 cells	3
Causes of discrepancies between medications listed in the national electronic prescribing system and patients' actual use of medications	3
Physicians' views on pharmacists' involvement in hospital deprescribing: A qualitative study on proton pump inhibitors	3
Blockade of Kv7 channels reverses the inhibitory effects of exchange protein directly activated by cAMP activation on purinergic contractions of the murine detrusor	3
Diloxanide in amoebiasis management: Unravelling the mechanism of action and effectiveness	3
Effect of bariatric surgery on the pharmacokinetics of drugs used for attention‐deficit hyperactivity disorder—A case series	3
	3
Epidemiological surveillance of drug safety using cumulative sequential analysis in electronic healthcare data	3
Kernel extreme learning with harmonized bat algorithm for prediction of pyrene toxicity in rats	3
No significant influence of OCT1 genotypes on the pharmacokinetics of morphine in adult surgical patients	3
A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD)	3
An extended substrate spectrum of the proton organic cation antiporter and relation to other cation transporters	3
Exploratory pharmacovigilance with machine learning in big patient data: A focused scoping review	3
Sapanisertib attenuates pulmonary fibrosis by modulating Wnt5a/mTOR signalling	3
Development and validation of an automated microfluidic perfusion platform for parallelized screening of compounds in vitro	3
Deaths caused by medication in persons not using illicit narcotic drugs: An autopsy study from Western Denmark	3
	3
Home therapy of COVID‐19 at the earliest may greatly prevent hospitalization	3
Welcome to Basic & Clinical Pharmacology & Toxicology 2024	3
The Patient Typology about deprescribing and medication‐related decisions: A quantitative exploration	3
Trends in medication use at the onset of and during the COVID‐19 pandemic in the Republic of Ireland: An interrupted time series study	3
The alleviatory effects of koumine on MSU‐induced gouty arthritis via the TLR4/NF‐κB/NLRP3 pathway	3
Methadone pharmacokinetics in opioid agonist treatment: Influencing factors and clinical implications	3
Deprescribing in a multimorbid older adult: A case vignette study among community pharmacists and primary care physicians	2
Issue Information	2
Alantolactone inhibits oesophageal adenocarcinoma cells through nuclear factor erythroid 2‐related factor 2‐mediated reactive oxygen species increment	2
Issue Information	2
	2
Issue Information	2
Metabolism studies of 4′Cl‐CUMYL‐PINACA, 4′F‐CUMYL‐5F‐PINACA and 4′F‐CUMYL‐5F‐PICA using human hepatocytes and LC‐QTOF‐MS analysis	2
Use of analgesics in Denmark: A national survey	2
Minimal alveolar concentration of sevoflurane in combination with dexmedetomidine in patients with hysteroscopy: An up‐down sequential allocation study	2
A review on the new age methodologies for early detection of Alzheimer's and Parkinson's disease	2
Oral Communications	2
Effects of dipyrone and acetylsalicylic acid on contractions of distal cauda epididymis duct, serum testosterone and sperm count in rats	2
Triptolide alleviates collagen‐induced arthritis in mice by modulating Treg/Th17 imbalance through the JAK/PTEN‐STAT3 pathway	2
The association of polymorphisms in related circadian rhythm genes and clopidogrel resistance susceptibility	2
Formate test for bedside diagnosis of methanol poisoning	2
	2
Fluoroquinolones as a trigger for rupture of abdominal aortic aneurysm: A case‐crossover analysis	2
Issue Information	2
Characteristics of patients receiving extended treatment after incident venous thromboembolism	2
Drug metabolism and drug transport of the 100 most prescribed oral drugs	2
Issue Information	2
Pharmacokinetics, bioequivalence and safety of two formulations of ticagrelor in healthy Chinese subjects: Effects of food	2
The mechanism of Epimedin B in treating osteoporosis as revealed by RNA sequencing‐based analysis	2
Association Between CYP2D6 Genotypes and Serum Concentrations of Mirtazapine and Mianserin	2
The Pathobiology of Cerebrovascular Lesions in CADASIL Small Vessel Disease	2
The association of four genetic variants with myelosuppression in gemcitabine‐treated Japanese is not evident in gemcitabine/carboplatin‐treated Swedes	2
Transfer of chemicals to a secondary container, from the introduction of new labelling regulation to COVID‐19 lockdown: A retrospective analysis of exposure calls to the Poison Control Centre of Rome,	2
A screen of pharmacologically active compounds to identify modulators of the Adgrg6/Gpr126 signalling pathway in zebrafish embryos	2
Use of deprescribing search filters in systematic review search strategies: A case study	2
Developing and testing complex behaviour change interventions to support proactive deprescribing: A narrative review	2
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY wishes to thank the following scientists, who have acted as reviewers during 2020–2021	2
Psychopharmacological treatment in patients planned for hip or knee replacement	2
Digoxin use and outcomes after myocardial infarction in patients with atrial fibrillation	2
Use of benzodiazepines and benzodiazepine‐related drugs in the Nordic countries between 2000 and 2020	2
	2
Chronic mercury exposure induces oxidative stress in female rats by endothelial nitric oxide synthase uncoupling and cyclooxygenase‐2 activation, without affecting oestrogen receptor function	2
Does lithium poisoning induce brain injuries?—A histopathological rat study	2
Dementia and depression: Biological connections with amyloid β protein	2
Decreased blood pressure with acute administration of quercetin in L‐NAME‐induced hypertensive rats	2
Issue Information	2
Melatonin protects cochlear hair cells from nicotine‐induced injury through inhibiting apoptosis, inflammation, oxidative stress and endoplasmic reticulum stress	2
Evaluation of the therapeutic role of allopurinol on bisphenol S gastric and renal toxicity in adult male albino rats: An in vivo study	2
Effect of albumin infusion on oxidative albumin modification and albumin binding capacity in chronic liver failure	2
Copper: From enigma to therapeutic target for neurological disorder	2