OOIR: Observatory of International Research

Papers

(The median citation count of Nanotoxicology is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Toxicity dose descriptors from animal inhalation studies of 13 nanomaterials and their bulk and ionic counterparts and variation with primary particle characteristics	73
The effect of natural biomolecules on yttrium oxide nanoparticles from a Daphnia magna survival rate perspective	54
Particulate matter constituents trigger the formation of extracellular amyloid β and Tau -containing plaques and neurite shortening in vitro	47
Potent lung tumor promotion by inhaled MWCNT	35
Bioinspired silk fibroin nano-delivery systems protect against 5-FU induced gastrointestinal mucositis in a mouse model and display antitumor effects on HT-29 colorectal cancer cells in vitro	34
Issues currently complicating the risk assessment of synthetic amorphous silica (SAS) nanoparticles after oral exposure	28
Cytotoxic evaluation of pure and doped iron oxide nanoparticles on cancer cells: a magnetic fluid hyperthermia perspective	25
Impact of polyethylene nanoplastics on human intestinal cells	25
Correction	24
Comparison of toxicity and cellular responses following pulmonary exposure to different types of nanofibers	21
Protein interaction, monocyte toxicity and immunogenic properties of cerium oxide crystals with 5% or 14% gadolinium, cobalt oxide and iron oxide nanoparticles – an interdisciplinary approach	20
Nanoparticle-protein corona complex: understanding multiple interactions between environmental factors, corona formation, and biological activity	18
Polyethyleneimine/polyethylene glycol–conjugated gold nanoparticles as nanoscale positive/negative controls in nanotoxicology: testing in frog embryo teratogenesis assay–Xenopusand mammalian ti	18
MMP-3 activation is involved in copper oxide nanoparticle-induced epithelial-mesenchymal transition in human lung epithelial cells	18
Algal extracellular polymeric substances (algal-EPS) for mitigating the combined toxic effects of polystyrene nanoplastics and nano-TiO₂ in Chlorella sp.	17
Assessment of acute and subacute toxicity, pharmacokinetics, and biodistribution of eugenol nanoparticles after oral exposure in Wistar rats	17
Microplastics and nanoplastics science: collecting and characterizing airborne microplastics in fine particulate matter	17
Predicting the toxicity of nanoparticles using artificial intelligence tools: a systematic review	17
Size effect and mucus role on the intestinal toxicity of the E551 food additive and engineered silica nanoparticles	16
Overview of potential adverse health effects of oral exposure to nanocellulose	15
Comparative study of the transcriptomes of Caco-2 cells cultured under dynamic vs. static conditions following exposure to titanium dioxide and zinc oxide nanomaterials	15
Multiparametric in vitro genotoxicity assessment of different variants of amorphous silica nanomaterials in rat alveolar epithelial cells	15
Genotoxic hazard assessment of cerium oxide and magnesium oxide nanoparticles in Drosophila	15
Correction	14
Carbon quantum dots in breast cancer modulate cellular migration via cytoskeletal and nuclear structure	14

Treatment of copper nanoparticles (CuNPs) for two spermatogenic cycles impairs testicular activity via down-regulating steroid receptors and inhibition of germ cell proliferation in a mice model	13
Immunotoxic effects of metal-based nanoparticles in fish and bivalves	12
Nano-read-across predictions of toxicity of metal oxide engineered nanoparticles (MeOx ENPS) used in nanopesticides to BEAS-2B and RAW 264.7 cells	12
X-ray spectrometry imaging and chemical speciation assisting to understand the toxic effects of copper oxide nanoparticles on zebrafish ( Danio rerio )	12
A harmonized protocol for an international multicenter prospective study of nanotechnology workers: the NanoExplore cohort	11
Exposure to gallium arsenide nanoparticles in a research facility: a case study using molecular beam epitaxy	11
Cabazitaxel-loaded poly(alkyl cyanoacrylate) nanoparticles: Toxicity and changes in the proteome of breast, colon and prostate cancer cells	11
The oxidative potential of nanomaterials: an optimized high-throughput protocol and interlaboratory comparison for the ferric reducing ability of serum (FRAS) assay	10
Modulating exosomal communication between macrophages and melanoma cancer cells via cyclodextrin-based nanosponges loaded with doxorubicin	10
Nanoparticles-encapsulated doxorubicin alleviates drug resistance of osteosarcoma via inducing ferroptosis	10
In vivo assessment of topically applied silver nanoparticles on entire cornea: comprehensive FTIR study	10
Quercetin protective potential against nanoparticle-induced adverse effects	10
AOP173 key event associated pathway predictor – online application for the prediction of benchmark dose lower bound (BMDLs) of a transcriptomic pathway involved in MWCNTs-induced lung fibrosis	10
Biomarkers of oxidative stress in urine and plasma of operators at six Singapore printing centers and their association with several metrics of printer-emitted nanoparticle exposures	10
Probing the effects of dextran-coated CeO ₂ nanoparticles on lung fibroblasts using multivariate single-cell Raman spectroscopy	10
The current advancements in chitosan nanoparticles in the management of non-surgical periodontitis treatment	9
Developing Integrated Approaches for Testing and Assessment (IATAs) in order to support nanomaterial safety	9
Preclinical evaluation of early multi-organ toxicity induced by liposomal doxorubicin using ⁶⁷Ga-citrate	8
Transgenic zebrafish larvae as a non-rodent alternative model to assess pro-inflammatory (neutrophil) responses to nanomaterials	8
Gestational exposure to silver nanoparticles enhances immune adaptation and protection against streptozotocin-induced diabetic nephropathy in mice offspring	8
3D volume segmentation and reconstruction. Supervised image classification and automated quantification of superparamagnetic iron oxide nanoparticles in histology slides for safety assessment	8
Graphene oxide influence in soil bacteria is dose dependent and changes at osmotic stress: growth variation, oxidative damage, antioxidant response, and plant growth promotion traits of a	7
Bioinformatics and machine learning to support nanomaterial grouping	7
Biodistribution and histological analysis of iron oxide-dextran nanoparticles in wistar rats	7
Photocatalytic activity of nanoparticles: the development of the standardized measurement for physiological conditions	7
Role of necroptosis of alveolar macrophages in acute lung inflammation of mice exposed to titanium dioxide nanoparticles	7
Polystyrene nanoparticles: the mechanism of their genotoxicity in human peripheral blood mononuclear cells	7
Enhanced toxicity of 2,2-bis(chloromethyl) trimethylene bis[bis(2-chloroethyl) phosphate] (V6) by nanopolystyrene particles towards HeLa cells	7
8-Hydroxy-2′-deoxyguanosine (8-OHdG) as a biomarker of oxidative DNA damage induced by occupational exposure to nanomaterials: a systematic review	6
A follow-up study on workers involved in the graphene production process after the introduction of exposure mitigation measures: evaluation of genotoxic and oxidative effects	6
Different cellular mechanisms from low- and high-dose zinc oxide nanoparticles-induced heart tube malformation during embryogenesis	6
Biokinetics of carbon black, multi-walled carbon nanotubes, cerium oxide, silica, and titanium dioxide nanoparticles after inhalation: a review	6
Nanosized titanium dioxide elevates toxicity of cationic metals species for Daphnia – have aging and natural organic matter an unexpected impact?	6
Toxicological impact of silver nanoparticles on soil microbial indicators in contaminated soil (pot experiment)	6
In vivo impact assessment of orally administered polystyrene nanoplastics: biodistribution, toxicity, and inflammatory response in mice	6
Efficient predictions of cytotoxicity of TiO₂-based multi-component nanoparticles using a machine learning-based q-RASAR approach	6
Effects of titanium oxide nanoparticles on growth, biochemical composition, and photosystem mechanism of marine microalgae Isochrysis galbana COR-A3	6
Perinatal exposure to silver nanoparticles reprograms immunometabolism and promotes pancreatic beta-cell death and kidney damage in mice	5
Study on myocardial toxicity induced by lead halide perovskites nanoparticles	5
Review of carbonaceous nanoparticles for antibacterial uses in various dental infections	5
Immunological properties of silica nanoparticles: a structure–activity relationship study	5
Protective effects of quercetin on intestinal barrier and cellular viability against silver nanoparticle exposure: insights from an intestinal co-culture model	5
Intraperitoneal hepatorenal toxicity of zinc oxide and nickel oxide nanoparticles in rats: a systematic review	4
Evaluation of anticancer activity of urotropine surface modified iron oxide nanoparticles using a panel of forty breast cancer cell lines	4
Lung toxicity, deposition, and clearance of thermal spray coating particles with different metal profiles after inhalation in rats	4
Ferritinophagy was involved in long-term SiNPs exposure induced ferroptosis and liver fibrosis	4
Distribution of gold nanoparticles into the brain: a systematic review and meta-analysis	4
Evaluation of the biodistribution and preliminary safety profile of a novel brain-targeted manganese dioxide-based nanotheranostic system for Alzheimer’s disease	4
Investigation of potential cytotoxicity of a water-soluble, red-fluorescent [70]fullerene nanomaterial in Drosophila melanogaster	4
Use of single particle ICP-MS to estimate silver nanoparticle penetration through baby porcine mucosa	4

In vitro and in silico study of mixtures cytotoxicity of metal oxide nanoparticles to Escherichia coli : a mechanistic	4
Proteome-wide analysis reveals molecular pathways affected by AgNP in a ROS-dependent manner	4
Intercellular transfer of mitochondria via tunneling nanotubes protects against cobalt nanoparticle-induced neurotoxicity and mitochondrial damage	4
Knock-out mouse models and single particle ICP-MS reveal that SP-D and SP-A deficiency reduces agglomeration of inhaled gold nanoparticles in vivo without significant changes to overall lung clearance	4
Chitosan functionalization of metal- and carbon-based nanomaterials as an approach toward sustainability tomorrow	4
Harmonizing nanomaterial exposure methodologies in ecotoxicology: the effects of two innovative nanoclays in the freshwater microalgae Raphidocelis subcapitata	4
Impacts of ingested MWCNT-Embedded nanocomposites in Japanese medaka (Oryzias latipes)	4
Impact of physico-chemical properties on the toxicological potential of reduced graphene oxide in human bronchial epithelial cells	4
Evaluation of mucosal immune profile associated with Zileuton nanocrystal-formulated BCS-II drug upon oral administration in Sprague Dawley rats	3
Repeated intratracheal instillation of zinc oxide nanoparticles induced pulmonary damage and a systemic inflammatory response in cynomolgus monkeys	3
Systematic review of mechanistic evidence for TiO ₂ nanoparticle-induced lung carcinogenicity	3
Reactive oxygen species production, genotoxicity and telomere length in FE1-Muta™Mouse lung epithelial cells exposed to carbon nanotubes	3
Acute hazard assessment of silver nanoparticles following intratracheal instillation, oral and intravenous injection exposures	3
Genoprotective role of pembrolizumab liposome in isolated lymphocytes from head and neck squamous cell carcinoma patients compared to those from healthy individuals in vitro	3
Ambient PM2.5 exposure causes cellular senescence via DNA damage, micronuclei formation, and cGAS activation	3
Food-grade titanium dioxide (E171) and zinc oxide nanoparticles induce mitochondrial permeability and cardiac damage after oral exposure in rats	3
Evaluating the antibacterial efficacy of a silver nanocomposite surface coating against nosocomial pathogens as an antibiofilm strategy to prevent hospital infections	3
TiO₂ nanostructures – a double edged sword: current progress on their role in stem cells’ differentiation, cancer therapy, and their toxicity issues	3
Nano-graphene oxide particles induce inheritable anomalies through altered gene expressions involved in oocyte maturation	3
A bibliometric analysis of the recent achievements in pulmonary safety of nanoparticles	3
Iron oxide nanoparticles cause surface coating- and core chemistry-dependent endothelial cell ferroptosis	3