OOIR: Observatory of International Research

Papers

(The median citation count of Particle and Fibre Toxicology is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Histopathology of the broad class of carbon nanotubes and nanofibers used or produced in U.S. facilities in a murine model	301
Single-cell transcriptome sequencing–based analysis: probing the mechanisms of glycoprotein NMB regulation of epithelial cells involved in silicosis	167
Lung function and self-rated symptoms in healthy volunteers after exposure to hydrotreated vegetable oil (HVO) exhaust with and without particles	103
Aryl hydrocarbon receptor activation-mediated vascular toxicity of ambient fine particulate matter: contribution of polycyclic aromatic hydrocarbons and osteopontin as a biomarker	96
Impact of in vitro digested zinc oxide nanoparticles on intestinal model systems	96
Toxicological inhalation studies in rats to substantiate grouping of zinc oxide nanoforms	94
Road tunnel-derived coarse, fine and ultrafine particulate matter: physical and chemical characterization and pro-inflammatory responses in human bronchial epithelial cells	92
An experimental study on lung deposition of inhaled 2 μm particles in relation to lung characteristics and deposition models	89
Placental-fetal distribution of carbon particles in a pregnant rabbit model after repeated exposure to diluted diesel engine exhaust	66
Toxicokinetic study following intratracheal instillation or oral gavage of two [7Be]-tagged carbon black samples	59
Impact on murine neurodevelopment of early-life exposure to airborne ultrafine carbon nanoparticles	57
Decidual derived exosomal miR-99a-5p targets Ppp2r5a to inhibit trophoblast invasion in response to CeO2NPs exposure	54
Titanium dioxide particles from the diet: involvement in the genesis of inflammatory bowel diseases and colorectal cancer	48
Polystyrene nanobeads exacerbate chronic colitis in mice involving in oxidative stress and hepatic lipid metabolism	46
An investigation of the internal morphology of asbestos ferruginous bodies: constraining their role in the onset of malignant mesothelioma	44
The pro-inflammatory effects of combined exposure to diesel exhaust particles and mineral particles in human bronchial epithelial cells	42
Short- and long-term pathologic responses to quartz are induced by nearly free silanols formed during crystal fracturing	40
Acute phase response following pulmonary exposure to soluble and insoluble metal oxide nanomaterials in mice	39
Prospects on the nano-plastic particles internalization and induction of cellular response in human keratinocytes	37
Attenuation of PM2.5-induced alveolar epithelial cells and lung injury through regulation of mitochondrial fission and fusion	36
Surface functionalization and size modulate the formation of reactive oxygen species and genotoxic effects of cellulose nanofibrils	36
ROS generation and p-38 activation contribute to montmorillonite-induced corneal toxicity in vitro and in vivo	35
Acute airway inflammation following controlled biodiesel exhaust exposure in healthy subjects	34
Serum peptidome: diagnostic window into pathogenic processes following occupational exposure to carbon nanomaterials	34
Correction: Reduction of pulmonary toxicity of metal oxide nanoparticles by phosphonate-based surface passivation	33

Establishing relationships between particle-induced in vitro and in vivo inflammation endpoints to better extrapolate between in vitro markers and in vivo fibrosis	32
Single inhalation exposure to polyamide micro and nanoplastic particles impairs vascular dilation without generating pulmonary inflammation in virgin female Sprague Dawley rats	31
Copper oxide nanoparticles trigger macrophage cell death with misfolding of Cu/Zn superoxide dismutase 1 (SOD1)	30
Silica-coated magnetic-nanoparticle-induced cytotoxicity is reduced in microglia by glutathione and citrate identified using integrated omics	29
A 90-day oral exposure to food-grade gold at relevant human doses impacts the gut microbiota and the local immune system in a sex-dependent manner in mice	29
Combined exposure to fine particulate matter and high glucose aggravates endothelial damage by increasing inflammation and mitophagy: the involvement of vitamin D	29
Food-grade titanium dioxide and zinc oxide nanoparticles induce toxicity and cardiac damage after oral exposure in rats	28
Effective density of inhaled environmental and engineered nanoparticles and its impact on the lung deposition and dosimetry	27
Dose–response relationship of pulmonary disorders by inhalation exposure to cross-linked water-soluble acrylic acid polymers in F344 rats	26
Airborne micro- and nanoplastics: emerging causes of respiratory diseases	26
Chronic effects of two rutile TiO2 nanomaterials in human intestinal and hepatic cell lines	25
Circulatory metabolites trigger ex vivo arterial endothelial cell dysfunction in population chronically exposed to diesel exhaust	25
Addressing the relevance of polystyrene nano- and microplastic particles used to support exposure, toxicity and risk assessment: implications and recommendations	25
Exposure to combustion derived particulate matter exacerbates influenza infection in neonatal mice by inhibiting IL22 production	25
Acute health effects of ambient air pollution including ultrafine particles in a semi-experimental setting in young, healthy individuals	23
The discovery of regional neurotoxicity-associated metabolic alterations induced by carbon quantum dots in brain of mice using a spatial metabolomics analysis	22
Ferroptosis contributing to cardiomyocyte injury induced by silica nanoparticles via miR-125b-2-3p/HO-1 signaling	22
Polystyrene nanoplastics exposure induces cognitive impairment in mice via induction of oxidative stress and ERK/MAPK-mediated neuronal cuproptosis	22
Silica encapsulation of ZnO nanoparticles reduces their toxicity for cumulus cell-oocyte-complex expansion	22
Type 1 diabetes and diet-induced obesity predispose C57BL/6J mice to PM2.5-induced lung injury: a comparative study	22
The potential involvement of inhaled iron (Fe) in the neurotoxic effects of ultrafine particulate matter air pollution exposure on brain development in mice	22
Hazard assessment of nanomaterials: how to meet the requirements for (next generation) risk assessment	21
Two-year intermittent exposure of a multiwalled carbon nanotube by intratracheal instillation induces lung tumors and pleural mesotheliomas in F344 rats	21
Epithelial MAPK signaling directs endothelial NRF2 signaling and IL-8 secretion in a tri-culture model of the alveolar-microvascular interface following diesel exhaust particulate (DEP) exposure	21
Long-term exposure to polystyrene microplastics triggers premature testicular aging	20
Compositional and structural analysis of engineered stones and inorganic particles in silicotic nodules of exposed workers	20
Derivation of first-order dissolution rates to estimate particle clearance and burden in the human respiratory tract	19
Combustion-derived carbon nanoparticles cause delayed apoptosis in neutrophil-like HL-60 cells in vitro and in primed human neutrophilic granulocytes ex vivo	19
Particulate matter from car exhaust alters function of human iPSC-derived microglia	19
Cellular response of keratinocytes to the entry and accumulation of nanoplastic particles	19
Polystyrene nanoplastics with different functional groups and charges have different impacts on type 2 diabetes	19
Prenatal PM2.5 exposure impairs spatial learning and memory in male mice offspring: from transcriptional regulation to neuronal morphogenesis	19
Murine in utero exposure to simulated complex urban air pollution disturbs offspring gut maturation and microbiota during intestinal suckling-to-weaning transition in a sex-dependent manner	19
Genome-wide DNA methylation sequencing reveals the involvement of ferroptosis in hepatotoxicity induced by dietary exposure to food-grade titanium dioxide	18
Influence of polyethylene terephthalate (PET) microplastic on selected active substances in the intramural neurons of the porcine duodenum	18
Chronic exposure to polystyrene microplastics induced male reproductive toxicity and decreased testosterone levels via the LH-mediated LHR/cAMP/PKA/StAR pathway	18
Difference in carcinogenicities of two different vapor grown carbon fibers with different physicochemical characteristics induced by intratracheal instillation in rats	17
Aluminium oxide nanoparticles compromise spatial memory performance and proBDNF-mediated neuronal function in the hippocampus of rats	17
Polycyclic aromatic hydrocarbons in urban particle matter exacerbate movement disorder after ischemic stroke via potentiation of neuroinflammation	16
Combining analytical techniques to assess the translocation of diesel particles across an alveolar tissue barrier in vitro	16
Putative adverse outcome pathways for silver nanoparticle toxicity on mammalian male reproductive system: a literature review	16
Diesel Exhaust Particle (DEP)-induced glucose intolerance is driven by an intestinal innate immune response and NLRP3 activation in mice	16
Microplastics are associated with elevated atherosclerotic risk and increased vascular complexity in acute coronary syndrome patients	16
The subacute toxicity and underlying mechanisms of biomimetic mesoporous polydopamine nanoparticles	16
Understanding the toxicological effects of TiO2 nanoparticles extracted from sunscreens on human keratinocytes and skin explants	15
Airway and systemic biomarkers of health effects after short-term exposure to indoor ultrafine particles from cooking and candles – A randomized controlled double-blind crossover study among mild asth	15
Chronic maternal exposure to titanium dioxide nanoparticles alters breathing in newborn offspring	15
Results from omic approaches in rat or mouse models exposed to inhaled crystalline silica: a systematic review	15
Exposure to high dose of polystyrene nanoplastics causes trophoblast cell apoptosis and induces miscarriage	15
Amorphous silica nanoparticles cause abnormal cytokinesis and multinucleation through dysfunction of the centralspindlin complex and microfilaments	15

In vitro-in vivo correlations of pulmonary inflammogenicity and genotoxicity of MWCNT	15
Immune consequences of exposure to β-pinene oxidation aerosols: adult versus gestational murine models	14
Concentration-dependent increase in symptoms due to diesel exhaust in a controlled human exposure study	14
Long-term PM2.5 exposure disrupts corneal epithelial homeostasis by impairing limbal stem/progenitor cells in humans and rat models	14
Human exposure to diesel exhaust induces CYP1A1 expression and AhR activation without a coordinated antioxidant response	14
Cytotoxicity analysis of biomass combustion particles in human pulmonary alveolar epithelial cells on an air–liquid interface/dynamic culture platform	14
Controlled human exposures: a review and comparison of the health effects of diesel exhaust and wood smoke	14
Oral toxicological study of titanium dioxide nanoparticles with a crystallite diameter of 6 nm in rats	14
MMP-3-mediated cleavage of OPN is involved in copper oxide nanoparticle-induced activation of fibroblasts	13
Underestimated health risks: polystyrene micro- and nanoplastics jointly induce intestinal barrier dysfunction by ROS-mediated epithelial cell apoptosis	13
A novel in-situ method to determine the respiratory tract deposition of carbonaceous particles reveals dangers of public commuting in highly polluted megacity	13
Correction: Perinatal foodborne titanium dioxide exposure-mediated dysbiosis predisposes mice to develop colitis through life	13
White matter pathology in alzheimer’s transgenic mice with chronic exposure to low-level ambient fine particulate matter	12
Lung recovery from DNA damage induced by graphene oxide is dependent on size, dose and inflammation profile	12
Systemic immunological responses are dependent on sex and ovarian hormone presence following acute inhaled woodsmoke exposure	12
Lung versus gut exposure to air pollution particles differentially affect metabolic health in mice	12
Controlled human exposure to diesel exhaust: results illuminate health effects of traffic-related air pollution and inform future directions	12
Biokinetics of subacutely co-inhaled same size gold and silver nanoparticles	12
Safe by design (SbD) and nanotechnology: a much-discussed topic with a prudence?	12
Repeated oral administration of low doses of silver in mice: tissue distribution and effects on central nervous system	12
Cell-nanoparticle stickiness and dose delivery in a multi-model in silico platform: DosiGUI	11
Correction: Central IKKβ Inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes	11
Correction: Combining analytical techniques to assess the translocation of diesel particles across an alveolar tissue barrier in vitro	11
Propionic acid/FBP1 is involved in polystyrene nanoplastic-induced cardiac injury via the gut-heart axis	11
Correction: a systematic quality evaluation and review of nanomaterial genotoxicity studies: a regulatory perspective	11
Oxidative stress generated by polycyclic aromatic hydrocarbons from ambient particulate matter enhance vascular smooth muscle cell migration through MMP upregulation and actin reorganization	10
Brain iron accumulation in neurodegenerative disorders: Does air pollution play a role?	10
Short- and long-term polystyrene nano- and microplastic exposure promotes oxidative stress and divergently affects skin cell architecture and Wnt/beta-catenin signaling	10
A comprehensive understanding of ambient particulate matter and its components on the adverse health effects based from epidemiological and laboratory evidence	10
Pro-inflammatory effects of inhaled Great Salt Lake dust particles	10
The application of existing genotoxicity methodologies for grouping of nanomaterials: towards an integrated approach to testing and assessment	10
The importance of mineralogical composition for the cytotoxic and pro-inflammatory effects of mineral dust	10
Macrophage-mediated tissue response evoked by subchronic inhalation of lead oxide nanoparticles is associated with the alteration of phospholipases C and cholesterol transporters	9
Fibrotic pulmonary dust foci is an advanced pneumoconiosis lesion in rats induced by titanium dioxide nanoparticles in a 2-year inhalation study	9
Comparison of PET tracing and biodistribution between 64Cu-labeled micro-and nano-polystyrene in a murine inhalation model	9
Hazard screening of colloidal silica nanomaterials with varying degrees of silane surface functionalization: a safe-by-design case study	9
Development of a multi-route physiologically based pharmacokinetic (PBPK) model for nanomaterials: a comparison between a traditional versus a new route-specific approach using gold nanoparticles in r	9
Grouping of orally ingested silica nanomaterials via use of an integrated approach to testing and assessment to streamline risk assessment	9
Omega-3 fatty acids attenuate cardiovascular effects of short-term exposure to ambient air pollution	9
Nano-titanium dioxide inhalation exposure during gestation drives redox dysregulation and vascular dysfunction across generations	9
Coal dust exposure triggers heterogeneity of transcriptional profiles in mouse pneumoconiosis and Vitamin D remedies	9
Correction to: Dose–response relationship of pulmonary disorders by inhalation exposure to cross-linked water-soluble acrylic acid polymers in F344 rats	9
Saharan dust induces NLRP3-dependent inflammatory cytokines in an alveolar air-liquid interface co-culture model	9
Polystyrene nanoplastic exposure induces excessive mitophagy by activating AMPK/ULK1 pathway in differentiated SH-SY5Y cells and dopaminergic neurons in vivo	9