OOIR: Observatory of International Research

Papers

(The median citation count of Particle and Fibre Toxicology is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Toxicological inhalation studies in rats to substantiate grouping of zinc oxide nanoforms	177
Lung retention, distribution and persistence of polymer particles in rats exposed via inhalation	169
Gut-ovary axis mediated synergistic reproductive toxicity of polystyrene nanoplastics and perfluorobutanoic acid co-exposure: pyroptotic signaling and probiotic mitigation	149
Single-cell transcriptome sequencing–based analysis: probing the mechanisms of glycoprotein NMB regulation of epithelial cells involved in silicosis	146
Aryl hydrocarbon receptor activation-mediated vascular toxicity of ambient fine particulate matter: contribution of polycyclic aromatic hydrocarbons and osteopontin as a biomarker	94
Impact of environmental microplastic exposure on HepG2 cells: unraveling proliferation, mitochondrial dynamics and autophagy activation	89
Placental-fetal distribution of carbon particles in a pregnant rabbit model after repeated exposure to diluted diesel engine exhaust	82
Fabrication of microplastic and nanoplastic particles and fibres for use in pulmonary toxicity studies	67
Toxicokinetic study following intratracheal instillation or oral gavage of two [7Be]-tagged carbon black samples	67
Emerging cardiovascular risks of micro- and nanoplastics: toxic effects and mechanistic pathways	65
An experimental study on lung deposition of inhaled 2 μm particles in relation to lung characteristics and deposition models	65
Road tunnel-derived coarse, fine and ultrafine particulate matter: physical and chemical characterization and pro-inflammatory responses in human bronchial epithelial cells	57
Decidual derived exosomal miR-99a-5p targets Ppp2r5a to inhibit trophoblast invasion in response to CeO2NPs exposure	56
Impact on murine neurodevelopment of early-life exposure to airborne ultrafine carbon nanoparticles	55
Correction: Pulmonary effects of exposure to indium and its compounds: cross-sectional survey of exposed workers and experimental findings in rodents	53
Exposure to ambient air pollution over developmental stages induced neurodevelopmental impairment in mice offspring via microbiome-gut-brain axis	52
Polystyrene nanobeads exacerbate chronic colitis in mice involving in oxidative stress and hepatic lipid metabolism	48
Short- and long-term pathologic responses to quartz are induced by nearly free silanols formed during crystal fracturing	46
Attenuation of PM2.5-induced alveolar epithelial cells and lung injury through regulation of mitochondrial fission and fusion	45
Acute phase response following pulmonary exposure to soluble and insoluble metal oxide nanomaterials in mice	42
An investigation of the internal morphology of asbestos ferruginous bodies: constraining their role in the onset of malignant mesothelioma	41
Fiber length and shape-dependent differences in hepatic nanomaterial localization in mice following pulmonary exposure	37
Renal transcriptome-wide analyses in association with kidney black carbon load	37
Correction: Reduction of pulmonary toxicity of metal oxide nanoparticles by phosphonate-based surface passivation	36
Acute airway inflammation following controlled biodiesel exhaust exposure in healthy subjects	36

Establishing relationships between particle-induced in vitro and in vivo inflammation endpoints to better extrapolate between in vitro markers and in vivo fibrosis	35
Single inhalation exposure to polyamide micro and nanoplastic particles impairs vascular dilation without generating pulmonary inflammation in virgin female Sprague Dawley rats	35
ROS generation and p-38 activation contribute to montmorillonite-induced corneal toxicity in vitro and in vivo	33
Ultraviolet irradiation-induced enhancement of inflammatory potential of polystyrene nano- and microplastics and effects of dispersion on lung clearance	33
A 90-day oral exposure to food-grade gold at relevant human doses impacts the gut microbiota and the local immune system in a sex-dependent manner in mice	32
Associations of prenatal fine particulate matter mixtures with neurodevelopmental outcomes in early childhood: component- and source-specific insights	32
Maternal PM2.5 exposure induces insulin resistance in adult male mouse offspring via gut–liver axis	31
Effective density of inhaled environmental and engineered nanoparticles and its impact on the lung deposition and dosimetry	31
Acute health effects of ambient air pollution including ultrafine particles in a semi-experimental setting in young, healthy individuals	30
Food-grade titanium dioxide and zinc oxide nanoparticles induce toxicity and cardiac damage after oral exposure in rats	30
Neurometabolomic impacts of wood smoke and protective benefits of anti-aging therapeutics in aged female C57BL/6J mice	30
Airborne micro- and nanoplastics: emerging causes of respiratory diseases	30
Pollutant particles enhance house dust mite induced type 2 inflammation and the recruitment of monocyte derived Cd11c+ Gpnmb+ macrophages to the airway lumen	30
Cerium dioxide nanoparticles coated with benzo[a]pyrene modify aryl hydrocarbon receptor activity, trophoblast differentiation and mitochondrial network phenotype in human placenta	29
Addressing the relevance of polystyrene nano- and microplastic particles used to support exposure, toxicity and risk assessment: implications and recommendations	28
Small particles, large questions: unravelling the toxicity and potential health risks of PET micro-/nanoplastics	28
Epithelial MAPK signaling directs endothelial NRF2 signaling and IL-8 secretion in a tri-culture model of the alveolar-microvascular interface following diesel exhaust particulate (DEP) exposure	26
Hazard assessment of nanomaterials: how to meet the requirements for (next generation) risk assessment	26
Ferroptosis contributing to cardiomyocyte injury induced by silica nanoparticles via miR-125b-2-3p/HO-1 signaling	26
The potential involvement of inhaled iron (Fe) in the neurotoxic effects of ultrafine particulate matter air pollution exposure on brain development in mice	25
The discovery of regional neurotoxicity-associated metabolic alterations induced by carbon quantum dots in brain of mice using a spatial metabolomics analysis	25
Type 1 diabetes and diet-induced obesity predispose C57BL/6J mice to PM2.5-induced lung injury: a comparative study	25
Polystyrene nanoplastics exposure induces cognitive impairment in mice via induction of oxidative stress and ERK/MAPK-mediated neuronal cuproptosis	25
A simple and reliable method for the qualitative and quantitative analysis of nano- and microplastics in organs for controlled preclinical studies	24
Particulate matter from car exhaust alters function of human iPSC-derived microglia	24
Combustion products of burn pit constituents induce more changes in asthmatic than non-asthmatic murine lungs	24
Long-term exposure to polystyrene microplastics triggers premature testicular aging	24
Murine in utero exposure to simulated complex urban air pollution disturbs offspring gut maturation and microbiota during intestinal suckling-to-weaning transition in a sex-dependent manner	24
Prenatal PM2.5 exposure impairs spatial learning and memory in male mice offspring: from transcriptional regulation to neuronal morphogenesis	23
Derivation of first-order dissolution rates to estimate particle clearance and burden in the human respiratory tract	23
Polystyrene nanoplastics with different functional groups and charges have different impacts on type 2 diabetes	22
Cellular response of keratinocytes to the entry and accumulation of nanoplastic particles	21
Cu(OH)2 nanopesticide triggered heart failure-like pathogenesis in mice by potentially targeting mmu-miRNA-590-3p and mmu-miRNA-338-5p in Wnt/β-catenin signaling	20
Genome-wide DNA methylation sequencing reveals the involvement of ferroptosis in hepatotoxicity induced by dietary exposure to food-grade titanium dioxide	20
Influence of polyethylene terephthalate (PET) microplastic on selected active substances in the intramural neurons of the porcine duodenum	20
Combustion-derived carbon nanoparticles cause delayed apoptosis in neutrophil-like HL-60 cells in vitro and in primed human neutrophilic granulocytes ex vivo	20
Combining analytical techniques to assess the translocation of diesel particles across an alveolar tissue barrier in vitro	19
Putative adverse outcome pathways for silver nanoparticle toxicity on mammalian male reproductive system: a literature review	19
Alignment of in vitro and in vivo pulmonary inflammation models using crystalline quartz silica	19
Understanding the toxicological effects of TiO2 nanoparticles extracted from sunscreens on human keratinocytes and skin explants	19
Difference in carcinogenicities of two different vapor grown carbon fibers with different physicochemical characteristics induced by intratracheal instillation in rats	19
Diesel Exhaust Particle (DEP)-induced glucose intolerance is driven by an intestinal innate immune response and NLRP3 activation in mice	18
The subacute toxicity and underlying mechanisms of biomimetic mesoporous polydopamine nanoparticles	18
Polycyclic aromatic hydrocarbons in urban particle matter exacerbate movement disorder after ischemic stroke via potentiation of neuroinflammation	18
Aged automobile cabin air filters as secondary pollution sources: mechanistic insights into NLRP3 inflammasome activation and discovery of a natural inhibitor	17
Chronic maternal exposure to titanium dioxide nanoparticles alters breathing in newborn offspring	17
Amorphous silica nanoparticles cause abnormal cytokinesis and multinucleation through dysfunction of the centralspindlin complex and microfilaments	17
Results from omic approaches in rat or mouse models exposed to inhaled crystalline silica: a systematic review	17
Microplastics are associated with elevated atherosclerotic risk and increased vascular complexity in acute coronary syndrome patients	17
Polystyrene microplastics and hepatic fibrosis-related indices in type 2 diabetes: a cross-sectional analysis with experimental validation	16

Oral toxicological study of titanium dioxide nanoparticles with a crystallite diameter of 6 nm in rats	16
Exposure to high dose of polystyrene nanoplastics causes trophoblast cell apoptosis and induces miscarriage	15
Seasonal PM2.5 exposures induce differential responses to influenza A virus infection in primary human airway epithelial cells	15
Immune consequences of exposure to β-pinene oxidation aerosols: adult versus gestational murine models	15
Airway and systemic biomarkers of health effects after short-term exposure to indoor ultrafine particles from cooking and candles – A randomized controlled double-blind crossover study among mild asth	15
Real-ambient PM2.5 exposure disrupts hematopoietic homeostasis via HIF-1α-driven myeloid skewing and promotes organ inflammation	14
Long-term PM2.5 exposure disrupts corneal epithelial homeostasis by impairing limbal stem/progenitor cells in humans and rat models	14
Concentration-dependent increase in symptoms due to diesel exhaust in a controlled human exposure study	13
Controlled human exposures: a review and comparison of the health effects of diesel exhaust and wood smoke	13
Human exposure to diesel exhaust induces CYP1A1 expression and AhR activation without a coordinated antioxidant response	13
MMP-3-mediated cleavage of OPN is involved in copper oxide nanoparticle-induced activation of fibroblasts	12
White matter pathology in alzheimer’s transgenic mice with chronic exposure to low-level ambient fine particulate matter	12
A novel in-situ method to determine the respiratory tract deposition of carbonaceous particles reveals dangers of public commuting in highly polluted megacity	12
Inhibition of protease-activated receptor-2 attenuates multi-walled carbon nanotube exacerbation of allergic lung disease in mice	12
Inhibition of PADI2-mediated vimentin citrullination alleviates silica-induced pulmonary fibrosis in mice	12
Correction: Perinatal foodborne titanium dioxide exposure-mediated dysbiosis predisposes mice to develop colitis through life	12
Particulate matter 2.5 promotes bladder cancer cell migration and invasion through the crosstalk between integrin-mediated MAPK/ERK and Wnt/β-catenin pathways	11
Cell-nanoparticle stickiness and dose delivery in a multi-model in silico platform: DosiGUI	11
Impact of surface functional group modification on cellular internalization and cytotoxicity of silica nanoparticles	11
Lung recovery from DNA damage induced by graphene oxide is dependent on size, dose and inflammation profile	10
Systemic immunological responses are dependent on sex and ovarian hormone presence following acute inhaled woodsmoke exposure	10
Lung versus gut exposure to air pollution particles differentially affect metabolic health in mice	10
Biokinetics of subacutely co-inhaled same size gold and silver nanoparticles	10
Supplemental exposure to polystyrene nanoplastics synergistically amplifies calcium oxalate crystal–induced injury to renal tubular epithelium, accelerating the formation of calcium oxalate kidney sto	9
Correction: Central IKKβ Inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes	9
Correction: a systematic quality evaluation and review of nanomaterial genotoxicity studies: a regulatory perspective	9
Correction: Combining analytical techniques to assess the translocation of diesel particles across an alveolar tissue barrier in vitro	9
Exposure to polylactic acid microplastics during puberty increases the risk of skeletal dysplasia by disrupting arachidonic acid metabolism in osteoblasts	8
Propionic acid/FBP1 is involved in polystyrene nanoplastic-induced cardiac injury via the gut-heart axis	8
The importance of mineralogical composition for the cytotoxic and pro-inflammatory effects of mineral dust	8
A comprehensive understanding of ambient particulate matter and its components on the adverse health effects based from epidemiological and laboratory evidence	8