OOIR: Observatory of International Research

Papers

(The H4-Index of Molecular Systems Biology is 44. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
The protein expression profile of ACE2 in human tissues	718
Ultra‐high sensitivity mass spectrometry quantifies single‐cell proteome changes upon perturbation	258
Probabilistic harmonization and annotation of single‐cell transcriptomics data with deep generative models	221
SBML Level 3: an extensible format for the exchange and reuse of biological models	180
Integrated intra‐ and intercellular signaling knowledge for multicellular omics analysis	158
Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease	154
Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation	136
RNA velocity—current challenges and future perspectives	133
Personalized whole‐body models integrate metabolism, physiology, and the gut microbiome	129
Using deep mutational scanning to benchmark variant effect predictors and identify disease mutations	120
Mapping the nucleolar proteome reveals a spatiotemporal organization related to intrinsic protein disorder	100
A single cell atlas of the human liver tumor microenvironment	98
Benchmarking AlphaFold ‐enabled molecular docking predictions for antibiotic discovery	95
Mass spectrometry‐based protein–protein interaction networks for the study of human diseases	93
From coarse to fine: the absolute Escherichia coli proteome under diverse growth conditions	86
hu.MAP 2.0: integration of over 15,000 proteomic experiments builds a global compendium of human multiprotein assemblies	84
scClassify: sample size estimation and multiscale classification of cells using single and multiple reference	80
Single‐cell analyses reveal SARS‐CoV‐2 interference with intrinsic immune response in the human gut	77
Causal integration of multi‐omics data with prior knowledge to generate mechanistic hypotheses	77
A new model for the HPA axis explains dysregulation of stress hormones on the timescale of weeks	76
Reproducibility in systems biology modelling	68
Predicting antigen specificity of single T cells based on TCR CDR 3 regions	68
Towards a mechanistic understanding of reciprocal drug–microbiome interactions	65
Slower growth of Escherichia coli leads to longer survival in carbon starvation due to a decrease in the maintenance rate	62
Drug mechanism‐of‐action discovery through the integration of pharmacological and CRISPR screens	62

Diagnostics and correction of batch effects in large‐scale proteomic studies: a tutorial	61
Identification of genomic enhancers through spatial integration of single‐cell transcriptomics and epigenomics	59
SARS‐CoV‐2–host proteome interactions for antiviral drug discovery	57
A guidebook for DISCO tissue clearing	56
Programmable CRISPR‐Cas transcriptional activation in bacteria	56
Evaluating the Arrhenius equation for developmental processes	55
Developmental function and state transitions of a gene expression oscillator in Caenorhabditis elegans	54
Dual lysine and N‐terminal acetyltransferases reveal the complexity underpinning protein acetylation	50
Joint cell segmentation and cell type annotation for spatial transcriptomics	49
High‐efficiency delivery of CRISPR‐Cas9 by engineered probiotics enables precise microbiome editing	48
COVID19 Disease Map, a computational knowledge repository of virus–host interaction mechanisms	48
High‐throughput, microscope‐based sorting to dissect cellular heterogeneity	48
In vitro and in vivo identification of clinically approved drugs that modify ACE 2	47
Enhancing scientific discoveries in molecular biology with deep generative models	46
P recision design of stable genetic circuits carried in highly‐insulated E. coli genomic landing pads	46
Predictive features of gene expression variation reveal mechanistic link with differential expression	45
RNA polymerase II clusters form in line with surface condensation on regulatory chromatin	45
Systematic analysis of bypass suppression of essential genes	44
Proteome constraints reveal targets for improving microbial fitness in nutrient‐rich environments	44
Predicting cellular responses to complex perturbations in high‐throughput screens	44
Protein complexes in cells by AI‐assisted structural proteomics	44