OOIR: Observatory of International Research

Papers

(The median citation count of Molecular Pain is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
T-type Ca²⁺ channels play a dual role in modulating the excitability of dorsal root ganglia neurons	54
Acute pulpitis promotes purinergic signaling to induce pain in rats via P38MAPK/NF-κB signaling pathway	27
Neural Adaptation of the Reward System in Primary Dysmenorrhea	25
Compartmentalized primary cultures of dorsal root ganglion neurons to model peripheral pathophysiological conditions	24
Analgesic effect of gastrin-releasing peptide in the dorsal horn	23
Effects of pain in lumbosacral stenosis and lifestyle-related factors on brain-derived neurotrophic factor expression profiles	22
EXPRESS: TLR3 mediates central sensitization in a chronic migraine model induced by repeated nitroglycerin through the ERK signaling pathway	19
Characterization of excitatory synaptic transmission in the retrosplenial cortex of adult mice	17
Dorsal column and root stimulation at Aβ-fiber intensity activate superficial dorsal horn glutamatergic and GABAergic populations	15
EXPRESS: Administration of 2-deoxy-D-glucose alleviates cancer-induced bone pain by suppressing microglial polarization to the M1 phenotype and neuroinflammation	15
Sigma-1 receptors and progesterone metabolizing enzymes in nociceptive sensory neurons of the female rat trigeminal ganglia: A neural substrate for the antinociceptive actions of progesterone	14
Recruitment of cortical silent responses by forskolin in the anterior cingulate cortex of adult mice	14
The transcription factor CCAAT/enhancer-binding protein β in spinal microglia contributes to pre-operative stress-induced prolongation of postsurgical pain	13
Phenotypic screen identifies the natural product silymarin as a novel anti-inflammatory analgesic	13
Probing pain aversion in rats with the “Heat Escape Threshold” paradigm	12
Methylglyoxal activates transient receptor potential A1/V1 via reactive oxygen species in the spinal dorsal horn	12
Persistent inflammatory pain is linked with anxiety-like behaviors, increased blood corticosterone, and reduced global DNA methylation in the rat amygdala	12
A note on estimating absolute cytosolic Ca²⁺ concentration in sensory neurons using a single wavelength Ca²⁺ indicator	12
Pain and aging: A unique challenge in neuroinflammation and behavior	12
ARG1 and CXCL2 are potential biomarkers target for psoriasis patients	11
EXPRESS: Unraveling the PVNGlu-PrLGlu Circuit: A New Frontier in Chronic Pain Management for Lumbar Disc Herniation	11
Upregulation of KDM6B in the anterior cingulate cortex contributes to neonatal maternal deprivation-induced chronic visceral pain in mice	11
Resolvin D1 attenuates mechanical allodynia after burn injury: Involvement of spinal glia, p38 mitogen-activated protein kinase, and brain-derived neurotrophic factor/tropomyosin-related kinase B sign	11
The role of visual expectations in acupuncture analgesia: A quantitative electroencephalography study	11
Inflammation in pathogenesis of chronic pain: Foe and friend	11

Spinal NLRP3 inflammasome activation mediates IL-1β release and contributes to remifentanil-induced postoperative hyperalgesia by regulating NMDA receptor NR1 subunit phosphorylation and GLT-1 express	10
Characteristics of immune cells and causal relationship with chondromalacia: A two-sample, bidirectional mendelian randomization study	10
miR-155-5p in the spinal cord regulates hypersensitivity in a rat model of bone cancer pain	10
Depression and anxiety in Chinese patients hospitalized with primary headache: A cross-sectional multicenter study	9
The holistic approach to the CHRNA7 gene, hsa-miR-3158-5p, and 15q13.3 hotspot CNVs in migraineurs	9
Rac1/PAK1 signaling contributes to bone cancer pain by Regulation dendritic spine remodeling in rats	9
Mechanical and cold polymodality coexist in tactile peripheral afferents, and it’s not mediated by TRPM8	9
Analyzing Substance Levels and Pain Perception in Painless Labor: The Impact of Spinal Epidural Analgesia	9
Spinal HDAC6 mediates nociceptive behaviors induced by chronic constriction injury via neuronal activation and neuroinflammation	9
Contribution of immune cells to cancer-related neuropathic pain: An updated review	8
Histamine H4 receptor and TRPV1 mediate itch induced by cadaverine, a metabolite of the microbiome	8
RETRACTED: Activation of the P2X7 receptor in the dental pulp tissue contributes to the pain in rats with acute pulpitis	8
TRIM14-NF-κB pathway in the anterior cingulate cortex modulates comorbid depressive symptoms in chronic pain	8
Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage	8
Epigenetic age predictors in community-dwelling adults with high impact knee pain	8
Sub-anaesthetic dose of propofol attenuates mechanical allodynia in chronic post-ischaemic pain via regulation of PTEN/PI3K/IL-6 signalling	7
Reduced capsaicin-induced mechanical allodynia and neuronal responses in the dorsal root ganglion in the presence of protein tyrosine phosphatase non-receptor type 6 overexpression	7
Protectin D1 ameliorates non-compressive lumbar disc herniation through SIRT1-mediated CGRP signaling	7
The effects of chronic high-dose morphine on microgliosis and the microglial transcriptome in rat spinal cord	7
The analgesic effects of β-elemene in rats with neuropathic pain by inhibition of spinal astrocytic ERK activation	7
Understanding the kynurenine pathway: A narrative review on its impact across chronic pain conditions	7
Involvement of interferon gamma signaling in spinal trigeminal caudal subnucleus astrocyte in orofacial neuropathic pain in rats with infraorbital nerve injury	7
Effects on low threshold mechanoreceptors in whisker hair follicles by 5-HT, Cd²⁺, tetraethylammonium, 4-aminopyridine, and Ba²⁺	7
Exploring novel non-opioid pathways and therapeutics for pain modulation	7
Sudan Black B treatment uncovers the distribution of angiotensin-converting enzyme2 in nociceptors	6
Spinal 5-HT_2A receptor is involved in electroacupuncture inhibition of chronic pain	6
AMPAkines have site-specific analgesic effects in the cortex	6
Activation of cyclin-dependent kinase 5 broadens action potentials in human sensory neurons	6
Silent synapses in pain-related anterior cingulate cortex	6
Mitochondrial transplantation attenuates traumatic neuropathic pain, neuroinflammation, and apoptosis in rats with nerve root ligation	6
Targeting Vascular endothelial growth factor A with soluble vascular endothelial growth factor receptor 1 ameliorates nerve injury-induced neuropathic pain	6
Effects of Fu’s subcutaneous needling on mitochondrial structure and function in rats with sciatica	6
PAQR8 and PAQR9 expression is altered in the ventral tegmental area of aged rats infected with varicella zoster virus	6
Sensitization of human and rat nociceptors by low dose morphine is toll-like receptor 4-dependent	5
Curcumin relieves CFA-induced inflammatory pain by inhibiting the AP-1/c-Jun-CCL2-CCR2 pathway in the spinal dorsal horn	5
Advanced cancer perineural invasion induces profound peripheral neuronal plasticity, pain, and somatosensory mechanical deactivation, unmitigated by the lack of TNFR1. Part 2. Biophysics and gene expr	5
Transcription factor ETS proto-oncogene 1 contributes to neuropathic pain by regulating histone deacetylase 1 in primary afferent neurons	5
Corrigendum to “Oxytocin inhibits hindpaw hyperalgesia induced by orofacial inflammation combined with stress”	5
Electroacupuncture ameliorates knee osteoarthritis in rats via inhibiting NLRP3 inflammasome and reducing pyroptosis	5
Projections from infralimbic medial prefrontal cortex glutamatergic outputs to amygdala mediates opioid induced hyperalgesia in male rats	5
Non-nociceptive and nociceptive-like trigeminal Aβ-afferent neurons of rats: Distinct electrophysiological properties, mechanical and chemical sensitivity	5
Electroacupuncture attenuates nociceptive behaviors in a mouse model of cancer pain	5
Unraveling the role of gut microbiota and plasma metabolites in fibromyalgia: Insights from Mendelian randomization and dietary interventions	5
Duloxetine prevents bortezomib and paclitaxel large-fiber chemotherapy-induced peripheral neuropathy (LF-CIPN) in sprague dawley rats	4
Neurotropin^® ameliorates chronic pain associated with scar formation in a mouse model: A gene expression analysis of the inflammatory response	4
Genetic evidence of the function of Phox2a-expressing anterolateral system neurons in the transmission of chronic pain	4
Whole-brain mapping of afferents to the anterior cingulate cortex in adult mice	4
Xanthohumol relieves arthritis pain in mice by suppressing mitochondrial-mediated inflammation	4
Gut microbiota-derived short-chain fatty acid suppresses the excitability of rat nociceptive secondary neurons via G-protein-coupled receptor 41 signaling	4
Polysorbate 80 blocked a peripheral sodium channel, Na_v1.7, and reduced neuronal excitability	4

Roles of mast cells and their interactions with the trigeminal nerve in migraine headache	4
Human safety study of a selective neuronal adenylate cyclase 1 inhibitor NB001 which relieves the neuropathic pain and blocks ACC in adult mice	4
Concomitant use of pre-emptive analgesia with local and general anesthesia in rat uterine pain surgical model	4
microRNA-181a contributes to gastric hypersensitivity in rats with diabetes by regulating TLR4 expression	4
Increased ten-eleven translocation methylcytosine dioxygenase one in dorsal root ganglion contributes to inflammatory pain in CFA rats	4
Dehydrocorydaline alleviates sleep deprivation-induced persistent postoperative pain in adolescent mice through inhibiting microglial P2Y₁₂ receptor expression in the spinal cord	4
Cholinergic modulation is independent of T lymphocytes in a mouse model of neuropathic pain	4
Urolithin A alleviates neuropathic pain and activates mitophagy	4
Loss and damage in large-diameter sensory neurons in the db/db diabetic mouse	3
Genetic basis of thermal nociceptive sensitivity and brain weight in a BALB/c reduced complexity cross	3
Melatonin attenuated chronic visceral pain by reducing Na_v1.8 expression and nociceptive neuronal sensitization	3
Rapid cleavage of IL-1β in DRG neurons produces tissue injury-induced pain hypersensitivity	3
Identification of genetic variations in μ opioid receptor in cats	3
Advanced cancer perineural invasion induces profound peripheral neuronal plasticity, pain, and somatosensory mechanical deactivation, unmitigated by the lack of TNFR1. Part. 1: Behavior and single-cel	3
KCC2 receptor upregulation potentiates antinociceptive effect of GABAAR agonist on remifentanil-induced hyperalgesia	3
Mitochondrial dysfunction and disulfidptosis co-regulate neuronal cell in neuropathic pain based on bioinformatics analysis	3
Ginsenoside Rh2 Ameliorates Neuropathic Pain by inhibition of the miRNA21-TLR8-mitogen-activated protein kinase axis	3
Low-frequency electroacupuncture exerts antinociceptive effects through activation of POMC neural circuit induced endorphinergic input to the periaqueductal gray from the arcuate nucleus	3
Pain-related behavioral and electrophysiological actions of dynorphin A (1-17)	3
Systematic analysis of inflammation and pain pathways in a mouse model of gout	3
The pace of biological aging helps explain the association between insomnia and chronic low back pain	3
Association between migraine and mitochondria: A Mendelian randomization study	3
Vascular endothelial growth factor-A/vascular endothelial growth factor2 signaling in spinal neurons contributes to bone cancer pain	3
Phytohormone abscisic acid ameliorates neuropathic pain via regulating LANCL2 protein abundance and glial activation at the spinal cord	3
Acute sleep deprivation aggravates nitroglycerin-evoked hyperalgesia in mice	3
Evaluation of the concentration of growth associated protein-43 and glial cell-derived neurotrophic factor in degenerated intervertebral discs of the lumbosacral region of the spine	3
NFATc2-dependent epigenetic downregulation of the TSC2/Beclin-1 pathway is involved in neuropathic pain induced by oxaliplatin	3
Puerarin improves the comorbidity of chronic pain and depression by binding with Bax and reducing mitochondrial dysfunction	3
Activation of neurons and satellite glial cells in the DRG produces morphine-induced hyperalgesia	2
Effects of administration of α₂ adrenergic receptor agonist into psoas major muscle on inflammatory pain induced by injection of complete Freund’s adjuvant in rats	2
Sophoridine alleviates hyperalgesia and anxiety-like behavior in an inflammatory pain mouse model induced by complete freund’s adjuvant	2
Effects of systemic oxytocin administration on ultraviolet B-induced nociceptive hypersensitivity and tactile hyposensitivity in mice	2
Mitochondrial reactivity following acute exposure to experimental pain testing in people with HIV and chronic pain	2
Single-nucleotide polymorphisms of the SLC17A9 and P2RY12 genes are significantly associated with phantom tooth pain	2
Temporal alterations of pituitary adenylate cyclase activating polypeptide and its receptors in a rat model induced by recurrent chemical stimulations: Relevant to chronic migraine	2
Newly discovered functions of miRNAs in neuropathic pain: Transitioning from recent discoveries to innovative underlying mechanisms	2
Whole-brain mapping of efferent projections of the anterior cingulate cortex in adult male mice	2
Oxytocin inhibits hindpaw hyperalgesia induced by orofacial inflammation combined with stress	2
Isolectin B4 (IB4)-conjugated streptavidin for the selective knockdown of proteins in IB4-positive (+) nociceptors	2
Probiotics attenuate alcohol-induced muscle mechanical hyperalgesia: Preliminary observations	2
Assessment of pain-related behaviors in HIV-1 transgenic rats as a model of HIV-associated chronic pain	2
In silico exploration of bioactive secondary metabolites with anesthetic effects on sodium channels Nav 1.7, 1.8, and 1.9 in painful human dental pulp	2
Fat mass and obesity-related protein contributes to the development and maintenance of bone cancer pain in rats by abrogating m6A methylation of RNA	2
Causal associations of immune cell phenotypes with migraine: A mendelian randomization study	2
Sound-induced analgesia cannot always be observed in adult mice	2
EXPRESS: Expression of Tacr1 and Gpr83 by spinal projection neurons	2
EXPRESS: Electroacupuncture intervention relieves pain by stimulating the STING/IFN-1 pathway in rat models of cancer-induced bone pain	2
Toll-like receptor 4 signaling pathway in sensory neurons mediates remifentanil-induced postoperative hyperalgesia via transient receptor potential ankyrin 1	2
Adverse effects of methylene blue in peripheral neurons: An in vitro electrophysiology and cell culture study	2
Phytochemical quercetin alleviates hyperexcitability of trigeminal nociceptive neurons associated with inflammatory hyperalgesia comparable to NSAIDs	2