OOIR: Observatory of International Research

Papers

(The median citation count of Molecular Pain is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Sophoridine alleviates hyperalgesia and anxiety-like behavior in an inflammatory pain mouse model induced by complete freund’s adjuvant	46
KCC2 receptor upregulation potentiates antinociceptive effect of GABAAR agonist on remifentanil-induced hyperalgesia	21
Compartmentalized primary cultures of dorsal root ganglion neurons to model peripheral pathophysiological conditions	19
Silencing of TRPV4-expressing sensory neurons attenuates temporomandibular disorders pain	19
Corrigendum to “Rac1/PAK1 signaling contributes to bone cancer pain by Regulation dendritic spine remodeling in rats”	19
Neural Adaptation of the Reward System in Primary Dysmenorrhea	18
Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage	18
Isolectin B4 (IB4)-conjugated streptavidin for the selective knockdown of proteins in IB4-positive (+) nociceptors	14
Role of ERK in gender difference of fibromyalgia pain	14
T-type Ca²⁺ channels play a dual role in modulating the excitability of dorsal root ganglia neurons	13
Depression and anxiety in Chinese patients hospitalized with primary headache: A cross-sectional multicenter study	12
Electroacupuncture attenuates nociceptive behaviors in a mouse model of cancer pain	12
Predicting long-term pain by combining brain imaging, genetics and health questionnaire data with Swedish national registries using a prospective superstruct design	12
Projections from infralimbic medial prefrontal cortex glutamatergic outputs to amygdala mediates opioid induced hyperalgesia in male rats	11
Morphine acts in vitro to directly prime nociceptors	11
Transcription factor ETS proto-oncogene 1 contributes to neuropathic pain by regulating histone deacetylase 1 in primary afferent neurons	11
Sound-induced analgesia cannot always be observed in adult mice	11
Acute pulpitis promotes purinergic signaling to induce pain in rats via P38MAPK/NF-κB signaling pathway	11
Advanced cancer perineural invasion induces profound peripheral neuronal plasticity, pain, and somatosensory mechanical deactivation, unmitigated by the lack of TNFR1. Part 2. Biophysics and gene expr	11
EXPRESS: PDCD4 Inhibition Alleviates Neuropathic Pain by regulating Spinal Autophagy and neuroinflammation	10
Whole-brain mapping of efferent projections of the anterior cingulate cortex in adult male mice	10
Mitochondrial dysfunction in trigeminal ganglion contribute to nociceptive behavior in a nitroglycerin-induced migraine mouse model	10
EXPRESS: Unraveling the Role of Gut Microbiota and Plasma Metabolites in Fibromyalgia: Insights from Mendelian Randomization and Dietary Interventions	10
Urolithin A alleviates neuropathic pain and activates mitophagy	9
Mechanisms of acupuncture–electroacupuncture on inflammatory pain	9

Concomitant use of pre-emptive analgesia with local and general anesthesia in rat uterine pain surgical model	9
Contribution of immune cells to cancer-related neuropathic pain: An updated review	9
Kilohertz high-frequency electrical stimulation ameliorate hyperalgesia by modulating transient receptor potential vanilloid-1 and N-methyl-D-aspartate receptor-2B signaling pathways in chronic constr	8
Armadillo regulates nociceptive sensitivity in the absence of injury	8
Xanthohumol relieves arthritis pain in mice by suppressing mitochondrial-mediated inflammation	8
Dimethyl fumarate attenuates pain behaviors in osteoarthritis rats via induction of Nrf2-mediated mitochondrial biogenesis	8
Gut microbiota-derived short-chain fatty acid suppresses the excitability of rat nociceptive secondary neurons via G-protein-coupled receptor 41 signaling	8
microRNA-181a contributes to gastric hypersensitivity in rats with diabetes by regulating TLR4 expression	8
Effects of administration of α₂ adrenergic receptor agonist into psoas major muscle on inflammatory pain induced by injection of complete Freund’s adjuvant in rats	8
Assessment of orofacial nociceptive behaviors of mice with the sheltering tube method: Oxaliplatin-induced mechanical and cold allodynia in orofacial regions	8
Human safety study of a selective neuronal adenylate cyclase 1 inhibitor NB001 which relieves the neuropathic pain and blocks ACC in adult mice	8
Whole-brain mapping of afferents to the anterior cingulate cortex in adult mice	7
Causal associations of immune cell phenotypes with migraine: A mendelian randomization study	7
Histamine H4 receptor and TRPV1 mediate itch induced by cadaverine, a metabolite of the microbiome	7
A-kinase anchoring protein 79/150 coordinates α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor sensitization in sensory neurons	7
RETRACTED: Activation of the P2X7 receptor in the dental pulp tissue contributes to the pain in rats with acute pulpitis	7
Esketamine inhibits the c-Jun N-terminal kinase pathway in the spinal dorsal horn to relieve bone cancer pain in rats	7
Methyltransferase-like 3 modulates visceral hypersensitivity through regulating the nuclear export of circKcnk9 in YTHDC1-dependent manner	7
Mapping thalamic-anterior cingulate monosynaptic inputs in adult mice	7
Pain sensitivity genes as therapeutic targets in knee osteoarthritis: A comprehensive analysis	7
The increased iron deposition of the gray matter over the whole brain in chronic migraine: An exploratory quantitative susceptibility mapping study	6
Analgesic effect of gastrin-releasing peptide in the dorsal horn	6
Effects of pain in lumbosacral stenosis and lifestyle-related factors on brain-derived neurotrophic factor expression profiles	6
Duloxetine prevents bortezomib and paclitaxel large-fiber chemotherapy-induced peripheral neuropathy (LF-CIPN) in sprague dawley rats	6
Cholinergic modulation is independent of T lymphocytes in a mouse model of neuropathic pain	5
Emodin alleviates arthritis pain through reducing spinal inflammation and oxidative stress	5
Peripheral sensory neurons and non-neuronal cells express functional Piezo1 channels	5
Activation of neurons and satellite glial cells in the DRG produces morphine-induced hyperalgesia	5
Epigenetic age predictors in community-dwelling adults with high impact knee pain	5
Newly discovered functions of miRNAs in neuropathic pain: Transitioning from recent discoveries to innovative underlying mechanisms	5
Electroacupuncture improves allodynia and central sensitization via modulation of microglial activation associated P2X4R and inflammation in a rat model of migraine	5
Characterisation of deep dorsal horn projection neurons in the spinal cord of the Phox2a::Cre mouse line	5
The analgesic effects of β-elemene in rats with neuropathic pain by inhibition of spinal astrocytic ERK activation	5
Evaluation of the concentration of growth associated protein-43 and glial cell-derived neurotrophic factor in degenerated intervertebral discs of the lumbosacral region of the spine	4
Grape seed-derived procyanidins decreases neuropathic pain and nerve regeneration by suppression of toll-like receptor 4-myeloid differentiation factor-88 signaling	4
Recruitment of cortical silent responses by forskolin in the anterior cingulate cortex of adult mice	4
Assessment of pain-related behaviors in HIV-1 transgenic rats as a model of HIV-associated chronic pain	4
Nociceptive signaling through transient receptor potential vanilloid 1 is regulated by Cyclin Dependent Kinase 5-mediated phosphorylation of T407 in vivo	4
Phenotypic screen identifies the natural product silymarin as a novel anti-inflammatory analgesic	4
Effects on low threshold mechanoreceptors in whisker hair follicles by 5-HT, Cd²⁺, tetraethylammonium, 4-aminopyridine, and Ba²⁺	4
Increased ten-eleven translocation methylcytosine dioxygenase one in dorsal root ganglion contributes to inflammatory pain in CFA rats	4
A novel anti-pruritic: Topical co-administration of high molecular weight hyaluronan (HMWH) with protamine, a transdermal transport enhancer	4
Neurotropin^® ameliorates chronic pain associated with scar formation in a mouse model: A gene expression analysis of the inflammatory response	4
Dehydrocorydaline alleviates sleep deprivation-induced persistent postoperative pain in adolescent mice through inhibiting microglial P2Y₁₂ receptor expression in the spinal cord	4
Phytohormone abscisic acid ameliorates neuropathic pain via regulating LANCL2 protein abundance and glial activation at the spinal cord	4
Genetic evidence of the function of Phox2a-expressing anterolateral system neurons in the transmission of chronic pain	4
Oxytocin inhibits hindpaw hyperalgesia induced by orofacial inflammation combined with stress	4
The effects of chronic high-dose morphine on microgliosis and the microglial transcriptome in rat spinal cord	4
Co-Administration of nalbuphine to improve morphine tolerance in mice with bone cancer pain	4
Involvement of interferon gamma signaling in spinal trigeminal caudal subnucleus astrocyte in orofacial neuropathic pain in rats with infraorbital nerve injury	3

Polysorbate 80 blocked a peripheral sodium channel, Na_v1.7, and reduced neuronal excitability	3
Altered intra- and inter-network functional activity among migraine, chronic migraine, and trigeminal neuralgia	3
L-Acetylcarnitine causes analgesia in mice modeling Fabry disease by up-regulating type-2 metabotropic glutamate receptors	3
Vascular endothelial growth factor-A/vascular endothelial growth factor2 signaling in spinal neurons contributes to bone cancer pain	3
EXPRESS: Loss and damage in large-diameter sensory neurons in the db/db diabetic mouse	3
Dorsal column and root stimulation at Aβ-fiber intensity activate superficial dorsal horn glutamatergic and GABAergic populations	3
Sigma-1 receptors and progesterone metabolizing enzymes in nociceptive sensory neurons of the female rat trigeminal ganglia: A neural substrate for the antinociceptive actions of progesterone	3
Fat mass and obesity-related protein contributes to the development and maintenance of bone cancer pain in rats by abrogating m6A methylation of RNA	3
Roles of mast cells and their interactions with the trigeminal nerve in migraine headache	3
Reduced capsaicin-induced mechanical allodynia and neuronal responses in the dorsal root ganglion in the presence of protein tyrosine phosphatase non-receptor type 6 overexpression	3
The transcription factor CCAAT/enhancer-binding protein β in spinal microglia contributes to pre-operative stress-induced prolongation of postsurgical pain	3
Effects of systemic oxytocin administration on ultraviolet B-induced nociceptive hypersensitivity and tactile hyposensitivity in mice	3
Protectin D1 ameliorates non-compressive lumbar disc herniation through SIRT1-mediated CGRP signaling	3
Ginsenoside Rh2 Ameliorates Neuropathic Pain by inhibition of the miRNA21-TLR8-mitogen-activated protein kinase axis	3
Exploring novel non-opioid pathways and therapeutics for pain modulation	3
In silico exploration of bioactive secondary metabolites with anesthetic effects on sodium channels Nav 1.7, 1.8, and 1.9 in painful human dental pulp	3
Silent synapses in pain-related anterior cingulate cortex	2
Offset analgesia is associated with opposing modulation of medial versus dorsolateral prefrontal cortex activations: A functional near-infrared spectroscopy study	2
Adverse effects of methylene blue in peripheral neurons: An in vitro electrophysiology and cell culture study	2
P2X7 receptor induces microglia polarization to the M1 phenotype in cancer-induced bone pain rat models	2
Retraction Notice	2
Activation of cyclin-dependent kinase 5 broadens action potentials in human sensory neurons	2
Acute sleep deprivation aggravates nitroglycerin-evoked hyperalgesia in mice	2
Genetic basis of thermal nociceptive sensitivity and brain weight in a BALB/c reduced complexity cross	2
Astrocyte-microglia interaction through C3/C3aR pathway modulates neuropathic pain in rats model of chronic constriction injury	2
Toll-like receptor 4 signaling pathway in sensory neurons mediates remifentanil-induced postoperative hyperalgesia via transient receptor potential ankyrin 1	2
Probiotics attenuate alcohol-induced muscle mechanical hyperalgesia: Preliminary observations	2
Targeting Vascular endothelial growth factor A with soluble vascular endothelial growth factor receptor 1 ameliorates nerve injury-induced neuropathic pain	2
Upregulation of KDM6B in the anterior cingulate cortex contributes to neonatal maternal deprivation-induced chronic visceral pain in mice	2
Sub-anaesthetic dose of propofol attenuates mechanical allodynia in chronic post-ischaemic pain via regulation of PTEN/PI3K/IL-6 signalling	2
Low-frequency electroacupuncture exerts antinociceptive effects through activation of POMC neural circuit induced endorphinergic input to the periaqueductal gray from the arcuate nucleus	2
Phytochemical quercetin alleviates hyperexcitability of trigeminal nociceptive neurons associated with inflammatory hyperalgesia comparable to NSAIDs	2
Resolvin D1 attenuates mechanical allodynia after burn injury: Involvement of spinal glia, p38 mitogen-activated protein kinase, and brain-derived neurotrophic factor/tropomyosin-related kinase B sign	2