OOIR: Observatory of International Research

Papers

(The median citation count of Molecular Pain is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Znhit1 alleviates nitroglycerin-induced hyperalgesia in migraine mice via the inhibition of NOD-like receptor signaling pathway	115
Neural adaptation of the reward system in primary dysmenorrhea	55
Acute pulpitis promotes purinergic signaling to induce pain in rats via P38MAPK/NF-κB signaling pathway	37
T-type Ca²⁺ channels play a dual role in modulating the excitability of dorsal root ganglia neurons	35
Compartmentalized primary cultures of dorsal root ganglion neurons to model peripheral pathophysiological conditions	33
TLR3 mediates central sensitization in a chronic migraine model induced by repeated nitroglycerin through the ERK signaling pathway	31
Viral vector-mediated interleukin 10 for gene therapy on chronic pain	25
Long-term effects on functional brain networks in adolescents treated for lumbar disc herniation	24
Effects of pain in lumbosacral stenosis and lifestyle-related factors on brain-derived neurotrophic factor expression profiles	23
Analgesic effect of gastrin-releasing peptide in the dorsal horn	23
Amino acid transporter SLC38A3 mediates bone cancer pain in rats via the PI3K/AKT/TRPV1 signaling pathway	23
Administration of 2-deoxy-D-glucose alleviates cancer-induced bone pain by suppressing microglial polarization to the M1 phenotype and neuroinflammation	22
Characterization of excitatory synaptic transmission in the retrosplenial cortex of adult mice	22
Phenotypic screen identifies the natural product silymarin as a novel anti-inflammatory analgesic	21
RIPK3 regulates microglial polarization through the TLR4/MyD88 pathway in neuropathic pain	21
EXPRESS: Evaluation of Stress Biomarkers in individuals with Migraine or Tension-Type headached before and after Botulinum Toxin Injection	19
Caffeic acid phenethyl ester attenuates inflammatory pain through promoting spinal microglial M1-to-M2 polarization by suppressing the PI3K/Akt/NF-κB pathway and attenuating peripheral inflammation	18
The transcription factor CCAAT/enhancer-binding protein β in spinal microglia contributes to pre-operative stress-induced prolongation of postsurgical pain	17
A note on estimating absolute cytosolic Ca²⁺ concentration in sensory neurons using a single wavelength Ca²⁺ indicator	17
Recruitment of cortical silent responses by forskolin in the anterior cingulate cortex of adult mice	17
Probing pain aversion in rats with the “Heat Escape Threshold” paradigm	16
Piezo1-mediated neuroexcitation via collaboration with KCa1.1 and Nav1.9 currents in myelinated Ah-type of trigeminal ganglion neurons in rats: Mechanistic insights with sex-specific effects	16
T cells modulate the development and maintenance of painful paclitaxel-induced peripheral neuropathy in RNU rats	16
Unraveling the PVN ^Glu -PrL ^Glu circuit: A new frontier in chronic pain management for lumbar disc	16
Resolvin D1 attenuates mechanical allodynia after burn injury: Involvement of spinal glia, p38 mitogen-activated protein kinase, and brain-derived neurotrophic factor/tropomyosin-related kinase B sign	15

Electroacupuncture at Zusanli (ST36) alleviates paclitaxel-induced neuropathic pain in rats via regulating TLR4 signaling pathway in the spinal cord	15
Persistent inflammatory pain is linked with anxiety-like behaviors, increased blood corticosterone, and reduced global DNA methylation in the rat amygdala	14
CGRP expression and signaling sensitization in a mouse model of chronic oxaliplatin-induced peripheral neuropathy	14
Upregulation of KDM6B in the anterior cingulate cortex contributes to neonatal maternal deprivation-induced chronic visceral pain in mice	14
Methylglyoxal activates transient receptor potential A1/V1 via reactive oxygen species in the spinal dorsal horn	14
Pain and aging: A unique challenge in neuroinflammation and behavior	13
miRNA-let7b5p alleviates visceral hypersensitivity by inhibiting the activation of spinal microglial in male IBS-like rats	12
Characteristics of immune cells and causal relationship with chondromalacia: A two-sample, bidirectional mendelian randomization study	12
Inflammation in pathogenesis of chronic pain: Foe and friend	12
ARG1 and CXCL2 are potential biomarkers target for psoriasis patients	12
The holistic approach to the CHRNA7 gene, hsa-miR-3158-5p, and 15q13.3 hotspot CNVs in migraineurs	11
Meningeal macrophages mask incision pain sensitization in male rats	11
Spinal NLRP3 inflammasome activation mediates IL-1β release and contributes to remifentanil-induced postoperative hyperalgesia by regulating NMDA receptor NR1 subunit phosphorylation and GLT-1 express	11
The role of visual expectations in acupuncture analgesia: A quantitative electroencephalography study	11
miR-155-5p in the spinal cord regulates hypersensitivity in a rat model of bone cancer pain	11
Analyzing Substance Levels and Pain Perception in Painless Labor: The Impact of Spinal Epidural Analgesia	11
Spinal HDAC6 mediates nociceptive behaviors induced by chronic constriction injury via neuronal activation and neuroinflammation	10
Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage	10
Mechanical and cold polymodality coexist in tactile peripheral afferents, and it’s not mediated by TRPM8	10
Application of XGBoost in the prediction of acute postoperative pain after major noncardiac surgery in older patients	10
Rac1/PAK1 signaling contributes to bone cancer pain by Regulation dendritic spine remodeling in rats	10
Spinal overexpression of CAPN1 in CaMKII neurons mediates paclitaxel-induced neuropathic pain via NCS-1-TRPV4 signaling	9
Identification of acetylation-related molecular signatures in knee osteoarthritis patients with significant response to warm-needle acupuncture using machine-learning approaches	9
Circadian gene NPAS2 modulates pain sensitization in CFA-induced inflammatory pain model	9
The analgesic effects of β-elemene in rats with neuropathic pain by inhibition of spinal astrocytic ERK activation	9
RETRACTED: Activation of the P2X7 receptor in the dental pulp tissue contributes to the pain in rats with acute pulpitis	9
Contribution of immune cells to cancer-related neuropathic pain: An updated review	9
Depression and anxiety in Chinese patients hospitalized with primary headache: A cross-sectional multicenter study	9
EXPRESS: Redox-Associated Gene and microRNA Signatures in Degenerative Intervertebral Disc Disease	8
TRIM14-NF-κB pathway in the anterior cingulate cortex modulates comorbid depressive symptoms in chronic pain	8
Reduced capsaicin-induced mechanical allodynia and neuronal responses in the dorsal root ganglion in the presence of protein tyrosine phosphatase non-receptor type 6 overexpression	8
Histamine H4 receptor and TRPV1 mediate itch induced by cadaverine, a metabolite of the microbiome	8
Epigenetic age predictors in community-dwelling adults with high impact knee pain	8
Protectin D1 ameliorates non-compressive lumbar disc herniation through SIRT1-mediated CGRP signaling	8
EXPRESS: Mechanism of asiatic acid in relieving psoriasis by modulating the PI3K/Akt/NF-κB pathway and NLRP3 inflammasome	8
The effects of chronic high-dose morphine on microgliosis and the microglial transcriptome in rat spinal cord	7
Silent synapses in pain-related anterior cingulate cortex	7
Analgesia and silymarin: What are the opportunities and challenges?	7
Exploring novel non-opioid pathways and therapeutics for pain modulation	7
Involvement of interferon gamma signaling in spinal trigeminal caudal subnucleus astrocyte in orofacial neuropathic pain in rats with infraorbital nerve injury	7
EXPRESS: A Road to Recovery: Transient Receptor Potential (TRP) Channels as Therapeutic Avenues for Spinal Cord Injury	7
Sub-anaesthetic dose of propofol attenuates mechanical allodynia in chronic post-ischaemic pain via regulation of PTEN/PI3K/IL-6 signalling	7
Exploring frequency-dependent and dynamic changes in brain connectivity of chronic back pain patients using degree centrality analysis	7
Targeting Vascular endothelial growth factor A with soluble vascular endothelial growth factor receptor 1 ameliorates nerve injury-induced neuropathic pain	7
AMPAkines have site-specific analgesic effects in the cortex	6
Effects of Fu’s subcutaneous needling on mitochondrial structure and function in rats with sciatica	6
EXPRESS: Therapeutic Modulation of Pain-related Affective Disorders by Acupuncture: Mechanistic Review	6
Corrigendum to “Oxytocin inhibits hindpaw hyperalgesia induced by orofacial inflammation combined with stress”	6
Understanding the kynurenine pathway: A narrative review on its impact across chronic pain conditions	6
Mitochondrial transplantation attenuates traumatic neuropathic pain, neuroinflammation, and apoptosis in rats with nerve root ligation	6

PAQR8 and PAQR9 expression is altered in the ventral tegmental area of aged rats infected with varicella zoster virus	6
Non-nociceptive and nociceptive-like trigeminal Aβ-afferent neurons of rats: Distinct electrophysiological properties, mechanical and chemical sensitivity	6
Activation of cyclin-dependent kinase 5 broadens action potentials in human sensory neurons	6
Lithium prevents the neurotoxic effects of paclitaxel mediated through TRPA1 channels	6
Curcumin relieves CFA-induced inflammatory pain by inhibiting the AP-1/c-Jun-CCL2-CCR2 pathway in the spinal dorsal horn	6
Sensitization of human and rat nociceptors by low dose morphine is toll-like receptor 4-dependent	6
Electroacupuncture attenuates nociceptive behaviors in a mouse model of cancer pain	5
Projections from infralimbic medial prefrontal cortex glutamatergic outputs to amygdala mediates opioid induced hyperalgesia in male rats	5
Gabapentin’s effect on human dorsal root ganglia: Donor-specific electrophysiological and transcriptomic profiles	5
Electroacupuncture ameliorates knee osteoarthritis in rats via inhibiting NLRP3 inflammasome and reducing pyroptosis	5
Gut microbiota-derived short-chain fatty acid suppresses the excitability of rat nociceptive secondary neurons via G-protein-coupled receptor 41 signaling	5
Transcription factor ETS proto-oncogene 1 contributes to neuropathic pain by regulating histone deacetylase 1 in primary afferent neurons	5
Mechanism of human umbilical cord mesenchymal stem cell-derived exosomes in alleviating neuropathic pain in CCI rats	5
Targeting sphingosine-1-phosphate receptor 1 alleviates neuropathic pain associated with pancreatic ductal adenocarcinoma in mice and inhibits tumor progression	5
Advanced cancer perineural invasion induces profound peripheral neuronal plasticity, pain, and somatosensory mechanical deactivation, unmitigated by the lack of TNFR1. Part 2. Biophysics and gene expr	5
Duloxetine prevents bortezomib and paclitaxel large-fiber chemotherapy-induced peripheral neuropathy (LF-CIPN) in sprague dawley rats	5
Unraveling the role of gut microbiota and plasma metabolites in fibromyalgia: Insights from Mendelian randomization and dietary interventions	5
EXPRESS: Interaction of Chronic Daily Headache, Dietary Intake of Iron, and FTO Genotype	5
Human safety study of a selective neuronal adenylate cyclase 1 inhibitor NB001 which relieves the neuropathic pain and blocks ACC in adult mice	4
Whole-brain mapping of afferents to the anterior cingulate cortex in adult mice	4
The involvement of spinal lncRNA RT1-CE10 in chronic functional visceral pain	4
Increased ten-eleven translocation methylcytosine dioxygenase one in dorsal root ganglion contributes to inflammatory pain in CFA rats	4
Genetic evidence of the function of Phox2a-expressing anterolateral system neurons in the transmission of chronic pain	4
Phytohormone abscisic acid ameliorates neuropathic pain via regulating LANCL2 protein abundance and glial activation at the spinal cord	4
Polysorbate 80 blocked a peripheral sodium channel, Na_v1.7, and reduced neuronal excitability	4
Xanthohumol relieves arthritis pain in mice by suppressing mitochondrial-mediated inflammation	4
Brain networking pain and anxiety: From basic mechanism to future treatment	4
Concomitant use of pre-emptive analgesia with local and general anesthesia in rat uterine pain surgical model	4
Evaluation of the concentration of growth associated protein-43 and glial cell-derived neurotrophic factor in degenerated intervertebral discs of the lumbosacral region of the spine	4
Loss and damage in large-diameter sensory neurons in the db/db diabetic mouse	4
Circulating microRNAs associated with acupuncture-induced Substance P reduction in chronic neck pain: Evidence for a neuroplasticity mechanism	4
Roles of mast cells and their interactions with the trigeminal nerve in migraine headache	4
Urolithin A alleviates neuropathic pain and activates mitophagy	4
Dehydrocorydaline alleviates sleep deprivation-induced persistent postoperative pain in adolescent mice through inhibiting microglial P2Y₁₂ receptor expression in the spinal cord	4
Neurotropin^® ameliorates chronic pain associated with scar formation in a mouse model: A gene expression analysis of the inflammatory response	4
microRNA-181a contributes to gastric hypersensitivity in rats with diabetes by regulating TLR4 expression	4
EXPRESS: Cortical mechanism of emotional pain	4
Ginsenoside Rh2 Ameliorates Neuropathic Pain by inhibition of the miRNA21-TLR8-mitogen-activated protein kinase axis	4
The enhanced analgesic effects of electroacupuncture and repetitive transcranial magnetic stimulation on visceral pain via ventral lateral septal nucleus	4
Honokiol and analgesia: A mechanistic review on the current capacities and challenges	3
Pain-related behavioral and electrophysiological actions of dynorphin A (1-17)	3
The butterfly effect and its electrical mechanism: Non-linear non-reciprocate sawtooth subthreshold oscillations deactivate nociceptors	3
Melatonin attenuated chronic visceral pain by reducing Na_v1.8 expression and nociceptive neuronal sensitization	3
Identification of genetic variations in μ opioid receptor in cats	3
The pace of biological aging helps explain the association between insomnia and chronic low back pain	3
Orbital tightening assessment to evaluate pain and physical discomfort in chlorine-exposed rats: A machine learning based measurement approach	3
Systematic analysis of inflammation and pain pathways in a mouse model of gout	3
Low-frequency electroacupuncture exerts antinociceptive effects through activation of POMC neural circuit induced endorphinergic input to the periaqueductal gray from the arcuate nucleus	3
FK506 causes pain by upregulating Na _V 1.7 channels in the spinal dorsal root ganglia of Na _V 1.7–	3
Mitochondrial dysfunction and disulfidptosis co-regulate neuronal cell in neuropathic pain based on bioinformatics analysis	3
MBD1-dependent recruitment of SUV39h1 induces H3K9me3-mediated transcriptional silencing of Oprm1 in dorsal root ganglia after peripheral nerve injury	3
Puerarin improves the comorbidity of chronic pain and depression by binding with Bax and reducing mitochondrial dysfunction	3
Risk factors associated with chronic pain and fibromyalgia-like symptoms post-COVID hospitalization	3
Association between migraine and mitochondria: A Mendelian randomization study	3
Acute sleep deprivation aggravates nitroglycerin-evoked hyperalgesia in mice	3
Rapid cleavage of IL-1β in DRG neurons produces tissue injury-induced pain hypersensitivity	3
EXPRESS: Systemic curcumin administration mitigates neuropathic pain in a rat model of trigeminal neuralgia by suppressing TNF-α and pSTAT3 signaling	3
NFATc2-dependent epigenetic downregulation of the TSC2/Beclin-1 pathway is involved in neuropathic pain induced by oxaliplatin	3
Advanced cancer perineural invasion induces profound peripheral neuronal plasticity, pain, and somatosensory mechanical deactivation, unmitigated by the lack of TNFR1. Part. 1: Behavior and single-cel	3