OOIR: Observatory of International Research

Papers

(The median citation count of Molecular Pain is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Acute pulpitis promotes purinergic signaling to induce pain in rats via P38MAPK/NF-κB signaling pathway	82
Neural Adaptation of the Reward System in Primary Dysmenorrhea	34
EXPRESS: Znhit1 alleviates nitroglycerin-induced hyperalgesia in migraine mice via the inhibition of NOD-like receptor signaling pathway	31
Compartmentalized primary cultures of dorsal root ganglion neurons to model peripheral pathophysiological conditions	29
T-type Ca²⁺ channels play a dual role in modulating the excitability of dorsal root ganglia neurons	29
Administration of 2-deoxy-D-glucose alleviates cancer-induced bone pain by suppressing microglial polarization to the M1 phenotype and neuroinflammation	25
RIPK3 regulates microglial polarization through the TLR4/MyD88 pathway in neuropathic pain	24
Characterization of excitatory synaptic transmission in the retrosplenial cortex of adult mice	20
EXPRESS: Viral Vector-mediated Interleukin 10 for Gene Therapy on Chronic Pain	19
Analgesic effect of gastrin-releasing peptide in the dorsal horn	19
Effects of pain in lumbosacral stenosis and lifestyle-related factors on brain-derived neurotrophic factor expression profiles	19
Long-term effects on functional brain networks in adolescents treated for lumbar disc herniation	19
TLR3 mediates central sensitization in a chronic migraine model induced by repeated nitroglycerin through the ERK signaling pathway	19
EXPRESS: Amino Acid Transporter SLC38A3 Mediates Bone Cancer Pain in Rats Via the PI3K/AKT/TRPV1 Signaling Pathway	18
The transcription factor CCAAT/enhancer-binding protein β in spinal microglia contributes to pre-operative stress-induced prolongation of postsurgical pain	17
Recruitment of cortical silent responses by forskolin in the anterior cingulate cortex of adult mice	16
Sigma-1 receptors and progesterone metabolizing enzymes in nociceptive sensory neurons of the female rat trigeminal ganglia: A neural substrate for the antinociceptive actions of progesterone	15
Phenotypic screen identifies the natural product silymarin as a novel anti-inflammatory analgesic	15
Upregulation of KDM6B in the anterior cingulate cortex contributes to neonatal maternal deprivation-induced chronic visceral pain in mice	14
Dorsal column and root stimulation at Aβ-fiber intensity activate superficial dorsal horn glutamatergic and GABAergic populations	14
Methylglyoxal activates transient receptor potential A1/V1 via reactive oxygen species in the spinal dorsal horn	13
Probing pain aversion in rats with the “Heat Escape Threshold” paradigm	13
A note on estimating absolute cytosolic Ca²⁺ concentration in sensory neurons using a single wavelength Ca²⁺ indicator	13
Inflammation in pathogenesis of chronic pain: Foe and friend	13
Unraveling the PVN ^Glu -PrL ^Glu circuit: A new frontier in chronic pain management for lumbar disc herniation	13

Resolvin D1 attenuates mechanical allodynia after burn injury: Involvement of spinal glia, p38 mitogen-activated protein kinase, and brain-derived neurotrophic factor/tropomyosin-related kinase B sign	12
ARG1 and CXCL2 are potential biomarkers target for psoriasis patients	12
Pain and aging: A unique challenge in neuroinflammation and behavior	12
Analyzing Substance Levels and Pain Perception in Painless Labor: The Impact of Spinal Epidural Analgesia	12
Persistent inflammatory pain is linked with anxiety-like behaviors, increased blood corticosterone, and reduced global DNA methylation in the rat amygdala	12
Characteristics of immune cells and causal relationship with chondromalacia: A two-sample, bidirectional mendelian randomization study	12
Rac1/PAK1 signaling contributes to bone cancer pain by Regulation dendritic spine remodeling in rats	11
Spinal NLRP3 inflammasome activation mediates IL-1β release and contributes to remifentanil-induced postoperative hyperalgesia by regulating NMDA receptor NR1 subunit phosphorylation and GLT-1 express	11
Spinal HDAC6 mediates nociceptive behaviors induced by chronic constriction injury via neuronal activation and neuroinflammation	11
The holistic approach to the CHRNA7 gene, hsa-miR-3158-5p, and 15q13.3 hotspot CNVs in migraineurs	11
The role of visual expectations in acupuncture analgesia: A quantitative electroencephalography study	11
Application of XGBoost in the prediction of acute postoperative pain after major noncardiac surgery in older patients	11
Meningeal macrophages mask incision pain sensitization in male rats	11
miR-155-5p in the spinal cord regulates hypersensitivity in a rat model of bone cancer pain	11
Contribution of immune cells to cancer-related neuropathic pain: An updated review	10
Circadian gene NPAS2 modulates pain sensitization in CFA-induced inflammatory pain model	10
Mechanical and cold polymodality coexist in tactile peripheral afferents, and it’s not mediated by TRPM8	10
Depression and anxiety in Chinese patients hospitalized with primary headache: A cross-sectional multicenter study	10
Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage	10
Histamine H4 receptor and TRPV1 mediate itch induced by cadaverine, a metabolite of the microbiome	10
Protectin D1 ameliorates non-compressive lumbar disc herniation through SIRT1-mediated CGRP signaling	9
The analgesic effects of β-elemene in rats with neuropathic pain by inhibition of spinal astrocytic ERK activation	9
TRIM14-NF-κB pathway in the anterior cingulate cortex modulates comorbid depressive symptoms in chronic pain	9
Effects on low threshold mechanoreceptors in whisker hair follicles by 5-HT, Cd²⁺, tetraethylammonium, 4-aminopyridine, and Ba²⁺	9
Epigenetic age predictors in community-dwelling adults with high impact knee pain	9
Exploring novel non-opioid pathways and therapeutics for pain modulation	9
RETRACTED: Activation of the P2X7 receptor in the dental pulp tissue contributes to the pain in rats with acute pulpitis	9
Reduced capsaicin-induced mechanical allodynia and neuronal responses in the dorsal root ganglion in the presence of protein tyrosine phosphatase non-receptor type 6 overexpression	8
The effects of chronic high-dose morphine on microgliosis and the microglial transcriptome in rat spinal cord	8
Sub-anaesthetic dose of propofol attenuates mechanical allodynia in chronic post-ischaemic pain via regulation of PTEN/PI3K/IL-6 signalling	8
Involvement of interferon gamma signaling in spinal trigeminal caudal subnucleus astrocyte in orofacial neuropathic pain in rats with infraorbital nerve injury	7
Sudan Black B treatment uncovers the distribution of angiotensin-converting enzyme2 in nociceptors	7
Understanding the kynurenine pathway: A narrative review on its impact across chronic pain conditions	7
Effects of Fu’s subcutaneous needling on mitochondrial structure and function in rats with sciatica	7
Silent synapses in pain-related anterior cingulate cortex	7
Analgesia and silymarin: What are the opportunities and challenges?	7
AMPAkines have site-specific analgesic effects in the cortex	7
Spinal 5-HT_2A receptor is involved in electroacupuncture inhibition of chronic pain	7
Activation of cyclin-dependent kinase 5 broadens action potentials in human sensory neurons	7
Targeting Vascular endothelial growth factor A with soluble vascular endothelial growth factor receptor 1 ameliorates nerve injury-induced neuropathic pain	7
Mitochondrial transplantation attenuates traumatic neuropathic pain, neuroinflammation, and apoptosis in rats with nerve root ligation	7
PAQR8 and PAQR9 expression is altered in the ventral tegmental area of aged rats infected with varicella zoster virus	6
Electroacupuncture ameliorates knee osteoarthritis in rats via inhibiting NLRP3 inflammasome and reducing pyroptosis	6
Transcription factor ETS proto-oncogene 1 contributes to neuropathic pain by regulating histone deacetylase 1 in primary afferent neurons	6
Corrigendum to “Oxytocin inhibits hindpaw hyperalgesia induced by orofacial inflammation combined with stress”	6
Non-nociceptive and nociceptive-like trigeminal Aβ-afferent neurons of rats: Distinct electrophysiological properties, mechanical and chemical sensitivity	6
Electroacupuncture attenuates nociceptive behaviors in a mouse model of cancer pain	6
Curcumin relieves CFA-induced inflammatory pain by inhibiting the AP-1/c-Jun-CCL2-CCR2 pathway in the spinal dorsal horn	6
Sensitization of human and rat nociceptors by low dose morphine is toll-like receptor 4-dependent	6
Unraveling the role of gut microbiota and plasma metabolites in fibromyalgia: Insights from Mendelian randomization and dietary interventions	6

Advanced cancer perineural invasion induces profound peripheral neuronal plasticity, pain, and somatosensory mechanical deactivation, unmitigated by the lack of TNFR1. Part 2. Biophysics and gene expr	6
Targeting sphingosine-1-phosphate receptor 1 alleviates neuropathic pain associated with pancreatic ductal adenocarcinoma in mice and inhibits tumor progression	5
microRNA-181a contributes to gastric hypersensitivity in rats with diabetes by regulating TLR4 expression	5
Cholinergic modulation is independent of T lymphocytes in a mouse model of neuropathic pain	5
Human safety study of a selective neuronal adenylate cyclase 1 inhibitor NB001 which relieves the neuropathic pain and blocks ACC in adult mice	5
Gut microbiota-derived short-chain fatty acid suppresses the excitability of rat nociceptive secondary neurons via G-protein-coupled receptor 41 signaling	5
Concomitant use of pre-emptive analgesia with local and general anesthesia in rat uterine pain surgical model	5
Whole-brain mapping of afferents to the anterior cingulate cortex in adult mice	5
Projections from infralimbic medial prefrontal cortex glutamatergic outputs to amygdala mediates opioid induced hyperalgesia in male rats	5
Gabapentin’s effect on human dorsal root ganglia: Donor-specific electrophysiological and transcriptomic profiles	5
The involvement of spinal lncRNA RT1-CE10 in chronic functional visceral pain	5
Phytohormone abscisic acid ameliorates neuropathic pain via regulating LANCL2 protein abundance and glial activation at the spinal cord	4
Xanthohumol relieves arthritis pain in mice by suppressing mitochondrial-mediated inflammation	4
Polysorbate 80 blocked a peripheral sodium channel, Na_v1.7, and reduced neuronal excitability	4
Neurotropin^® ameliorates chronic pain associated with scar formation in a mouse model: A gene expression analysis of the inflammatory response	4
Roles of mast cells and their interactions with the trigeminal nerve in migraine headache	4
Dehydrocorydaline alleviates sleep deprivation-induced persistent postoperative pain in adolescent mice through inhibiting microglial P2Y₁₂ receptor expression in the spinal cord	4
Urolithin A alleviates neuropathic pain and activates mitophagy	4
Loss and damage in large-diameter sensory neurons in the db/db diabetic mouse	4
Vascular endothelial growth factor-A/vascular endothelial growth factor2 signaling in spinal neurons contributes to bone cancer pain	4
Increased ten-eleven translocation methylcytosine dioxygenase one in dorsal root ganglion contributes to inflammatory pain in CFA rats	4
Duloxetine prevents bortezomib and paclitaxel large-fiber chemotherapy-induced peripheral neuropathy (LF-CIPN) in sprague dawley rats	4
Genetic evidence of the function of Phox2a-expressing anterolateral system neurons in the transmission of chronic pain	4
Evaluation of the concentration of growth associated protein-43 and glial cell-derived neurotrophic factor in degenerated intervertebral discs of the lumbosacral region of the spine	4
Genetic basis of thermal nociceptive sensitivity and brain weight in a BALB/c reduced complexity cross	4
Sound-induced analgesia cannot always be observed in adult mice	3
Identification of genetic variations in μ opioid receptor in cats	3
EXPRESS: MBD1-dependent recruitment of SUV39h1 induces H3K9me3-mediated transcriptional silencing of Oprm1 in dorsal root ganglia after peripheral nerve injury	3
Acute sleep deprivation aggravates nitroglycerin-evoked hyperalgesia in mice	3
Low-frequency electroacupuncture exerts antinociceptive effects through activation of POMC neural circuit induced endorphinergic input to the periaqueductal gray from the arcuate nucleus	3
Pain-related behavioral and electrophysiological actions of dynorphin A (1-17)	3
NFATc2-dependent epigenetic downregulation of the TSC2/Beclin-1 pathway is involved in neuropathic pain induced by oxaliplatin	3
Isolectin B4 (IB4)-conjugated streptavidin for the selective knockdown of proteins in IB4-positive (+) nociceptors	3
Puerarin improves the comorbidity of chronic pain and depression by binding with Bax and reducing mitochondrial dysfunction	3
Rapid cleavage of IL-1β in DRG neurons produces tissue injury-induced pain hypersensitivity	3
Melatonin attenuated chronic visceral pain by reducing Na_v1.8 expression and nociceptive neuronal sensitization	3
Mitochondrial dysfunction and disulfidptosis co-regulate neuronal cell in neuropathic pain based on bioinformatics analysis	3
Systematic analysis of inflammation and pain pathways in a mouse model of gout	3
Expression of Tacr1 and Gpr83 by spinal projection neurons	3
The pace of biological aging helps explain the association between insomnia and chronic low back pain	3
Advanced cancer perineural invasion induces profound peripheral neuronal plasticity, pain, and somatosensory mechanical deactivation, unmitigated by the lack of TNFR1. Part. 1: Behavior and single-cel	3
Ginsenoside Rh2 Ameliorates Neuropathic Pain by inhibition of the miRNA21-TLR8-mitogen-activated protein kinase axis	3
EXPRESS: The Butterfly Effect and Its Electrical Mechanism: Non-Linear Non-Reciprocate Sawtooth Subthreshold Oscillations Deactivate Nociceptors.	3
Association between migraine and mitochondria: A Mendelian randomization study	3
KCC2 receptor upregulation potentiates antinociceptive effect of GABAAR agonist on remifentanil-induced hyperalgesia	3