OOIR: Observatory of International Research

Papers

(The TQCC of Molecular Pain is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
T-type Ca²⁺ channels play a dual role in modulating the excitability of dorsal root ganglia neurons	54
Acute pulpitis promotes purinergic signaling to induce pain in rats via P38MAPK/NF-κB signaling pathway	27
Neural Adaptation of the Reward System in Primary Dysmenorrhea	25
Compartmentalized primary cultures of dorsal root ganglion neurons to model peripheral pathophysiological conditions	24
Analgesic effect of gastrin-releasing peptide in the dorsal horn	23
Effects of pain in lumbosacral stenosis and lifestyle-related factors on brain-derived neurotrophic factor expression profiles	22
EXPRESS: TLR3 mediates central sensitization in a chronic migraine model induced by repeated nitroglycerin through the ERK signaling pathway	19
Characterization of excitatory synaptic transmission in the retrosplenial cortex of adult mice	17
Dorsal column and root stimulation at Aβ-fiber intensity activate superficial dorsal horn glutamatergic and GABAergic populations	15
EXPRESS: Administration of 2-deoxy-D-glucose alleviates cancer-induced bone pain by suppressing microglial polarization to the M1 phenotype and neuroinflammation	15
Recruitment of cortical silent responses by forskolin in the anterior cingulate cortex of adult mice	14
Sigma-1 receptors and progesterone metabolizing enzymes in nociceptive sensory neurons of the female rat trigeminal ganglia: A neural substrate for the antinociceptive actions of progesterone	14
Phenotypic screen identifies the natural product silymarin as a novel anti-inflammatory analgesic	13
The transcription factor CCAAT/enhancer-binding protein β in spinal microglia contributes to pre-operative stress-induced prolongation of postsurgical pain	13
Persistent inflammatory pain is linked with anxiety-like behaviors, increased blood corticosterone, and reduced global DNA methylation in the rat amygdala	12
A note on estimating absolute cytosolic Ca²⁺ concentration in sensory neurons using a single wavelength Ca²⁺ indicator	12
Pain and aging: A unique challenge in neuroinflammation and behavior	12
Probing pain aversion in rats with the “Heat Escape Threshold” paradigm	12
Methylglyoxal activates transient receptor potential A1/V1 via reactive oxygen species in the spinal dorsal horn	12
The role of visual expectations in acupuncture analgesia: A quantitative electroencephalography study	11
Inflammation in pathogenesis of chronic pain: Foe and friend	11
ARG1 and CXCL2 are potential biomarkers target for psoriasis patients	11
EXPRESS: Unraveling the PVNGlu-PrLGlu Circuit: A New Frontier in Chronic Pain Management for Lumbar Disc Herniation	11
Upregulation of KDM6B in the anterior cingulate cortex contributes to neonatal maternal deprivation-induced chronic visceral pain in mice	11
Resolvin D1 attenuates mechanical allodynia after burn injury: Involvement of spinal glia, p38 mitogen-activated protein kinase, and brain-derived neurotrophic factor/tropomyosin-related kinase B sign	11

miR-155-5p in the spinal cord regulates hypersensitivity in a rat model of bone cancer pain	10
Spinal NLRP3 inflammasome activation mediates IL-1β release and contributes to remifentanil-induced postoperative hyperalgesia by regulating NMDA receptor NR1 subunit phosphorylation and GLT-1 express	10
Characteristics of immune cells and causal relationship with chondromalacia: A two-sample, bidirectional mendelian randomization study	10
Analyzing Substance Levels and Pain Perception in Painless Labor: The Impact of Spinal Epidural Analgesia	9
Spinal HDAC6 mediates nociceptive behaviors induced by chronic constriction injury via neuronal activation and neuroinflammation	9
Depression and anxiety in Chinese patients hospitalized with primary headache: A cross-sectional multicenter study	9
The holistic approach to the CHRNA7 gene, hsa-miR-3158-5p, and 15q13.3 hotspot CNVs in migraineurs	9
Rac1/PAK1 signaling contributes to bone cancer pain by Regulation dendritic spine remodeling in rats	9
Mechanical and cold polymodality coexist in tactile peripheral afferents, and it’s not mediated by TRPM8	9
Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage	8
Epigenetic age predictors in community-dwelling adults with high impact knee pain	8
Contribution of immune cells to cancer-related neuropathic pain: An updated review	8
Histamine H4 receptor and TRPV1 mediate itch induced by cadaverine, a metabolite of the microbiome	8
RETRACTED: Activation of the P2X7 receptor in the dental pulp tissue contributes to the pain in rats with acute pulpitis	8
TRIM14-NF-κB pathway in the anterior cingulate cortex modulates comorbid depressive symptoms in chronic pain	8
Understanding the kynurenine pathway: A narrative review on its impact across chronic pain conditions	7
Involvement of interferon gamma signaling in spinal trigeminal caudal subnucleus astrocyte in orofacial neuropathic pain in rats with infraorbital nerve injury	7
Effects on low threshold mechanoreceptors in whisker hair follicles by 5-HT, Cd²⁺, tetraethylammonium, 4-aminopyridine, and Ba²⁺	7
Exploring novel non-opioid pathways and therapeutics for pain modulation	7
Sub-anaesthetic dose of propofol attenuates mechanical allodynia in chronic post-ischaemic pain via regulation of PTEN/PI3K/IL-6 signalling	7
Reduced capsaicin-induced mechanical allodynia and neuronal responses in the dorsal root ganglion in the presence of protein tyrosine phosphatase non-receptor type 6 overexpression	7
Protectin D1 ameliorates non-compressive lumbar disc herniation through SIRT1-mediated CGRP signaling	7
The effects of chronic high-dose morphine on microgliosis and the microglial transcriptome in rat spinal cord	7
The analgesic effects of β-elemene in rats with neuropathic pain by inhibition of spinal astrocytic ERK activation	7
Targeting Vascular endothelial growth factor A with soluble vascular endothelial growth factor receptor 1 ameliorates nerve injury-induced neuropathic pain	6
Effects of Fu’s subcutaneous needling on mitochondrial structure and function in rats with sciatica	6
PAQR8 and PAQR9 expression is altered in the ventral tegmental area of aged rats infected with varicella zoster virus	6
Sudan Black B treatment uncovers the distribution of angiotensin-converting enzyme2 in nociceptors	6
Spinal 5-HT_2A receptor is involved in electroacupuncture inhibition of chronic pain	6
AMPAkines have site-specific analgesic effects in the cortex	6
Activation of cyclin-dependent kinase 5 broadens action potentials in human sensory neurons	6
Silent synapses in pain-related anterior cingulate cortex	6
Mitochondrial transplantation attenuates traumatic neuropathic pain, neuroinflammation, and apoptosis in rats with nerve root ligation	6