OOIR: Observatory of International Research

Papers

(The TQCC of Molecular Pain is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Acute pulpitis promotes purinergic signaling to induce pain in rats via P38MAPK/NF-κB signaling pathway	82
Neural Adaptation of the Reward System in Primary Dysmenorrhea	34
EXPRESS: Znhit1 alleviates nitroglycerin-induced hyperalgesia in migraine mice via the inhibition of NOD-like receptor signaling pathway	31
T-type Ca²⁺ channels play a dual role in modulating the excitability of dorsal root ganglia neurons	29
Compartmentalized primary cultures of dorsal root ganglion neurons to model peripheral pathophysiological conditions	29
Administration of 2-deoxy-D-glucose alleviates cancer-induced bone pain by suppressing microglial polarization to the M1 phenotype and neuroinflammation	25
RIPK3 regulates microglial polarization through the TLR4/MyD88 pathway in neuropathic pain	24
Characterization of excitatory synaptic transmission in the retrosplenial cortex of adult mice	20
Analgesic effect of gastrin-releasing peptide in the dorsal horn	19
Effects of pain in lumbosacral stenosis and lifestyle-related factors on brain-derived neurotrophic factor expression profiles	19
Long-term effects on functional brain networks in adolescents treated for lumbar disc herniation	19
TLR3 mediates central sensitization in a chronic migraine model induced by repeated nitroglycerin through the ERK signaling pathway	19
EXPRESS: Viral Vector-mediated Interleukin 10 for Gene Therapy on Chronic Pain	19
EXPRESS: Amino Acid Transporter SLC38A3 Mediates Bone Cancer Pain in Rats Via the PI3K/AKT/TRPV1 Signaling Pathway	18
The transcription factor CCAAT/enhancer-binding protein β in spinal microglia contributes to pre-operative stress-induced prolongation of postsurgical pain	17
Recruitment of cortical silent responses by forskolin in the anterior cingulate cortex of adult mice	16
Phenotypic screen identifies the natural product silymarin as a novel anti-inflammatory analgesic	15
Sigma-1 receptors and progesterone metabolizing enzymes in nociceptive sensory neurons of the female rat trigeminal ganglia: A neural substrate for the antinociceptive actions of progesterone	15
Dorsal column and root stimulation at Aβ-fiber intensity activate superficial dorsal horn glutamatergic and GABAergic populations	14
Upregulation of KDM6B in the anterior cingulate cortex contributes to neonatal maternal deprivation-induced chronic visceral pain in mice	14
Probing pain aversion in rats with the “Heat Escape Threshold” paradigm	13
A note on estimating absolute cytosolic Ca²⁺ concentration in sensory neurons using a single wavelength Ca²⁺ indicator	13
Inflammation in pathogenesis of chronic pain: Foe and friend	13
Unraveling the PVN ^Glu -PrL ^Glu circuit: A new frontier in chronic pain management for lumbar disc herniation	13
Methylglyoxal activates transient receptor potential A1/V1 via reactive oxygen species in the spinal dorsal horn	13

Resolvin D1 attenuates mechanical allodynia after burn injury: Involvement of spinal glia, p38 mitogen-activated protein kinase, and brain-derived neurotrophic factor/tropomyosin-related kinase B sign	12
ARG1 and CXCL2 are potential biomarkers target for psoriasis patients	12
Pain and aging: A unique challenge in neuroinflammation and behavior	12
Analyzing Substance Levels and Pain Perception in Painless Labor: The Impact of Spinal Epidural Analgesia	12
Persistent inflammatory pain is linked with anxiety-like behaviors, increased blood corticosterone, and reduced global DNA methylation in the rat amygdala	12
Characteristics of immune cells and causal relationship with chondromalacia: A two-sample, bidirectional mendelian randomization study	12
Spinal HDAC6 mediates nociceptive behaviors induced by chronic constriction injury via neuronal activation and neuroinflammation	11
The holistic approach to the CHRNA7 gene, hsa-miR-3158-5p, and 15q13.3 hotspot CNVs in migraineurs	11
The role of visual expectations in acupuncture analgesia: A quantitative electroencephalography study	11
Application of XGBoost in the prediction of acute postoperative pain after major noncardiac surgery in older patients	11
Meningeal macrophages mask incision pain sensitization in male rats	11
miR-155-5p in the spinal cord regulates hypersensitivity in a rat model of bone cancer pain	11
Rac1/PAK1 signaling contributes to bone cancer pain by Regulation dendritic spine remodeling in rats	11
Spinal NLRP3 inflammasome activation mediates IL-1β release and contributes to remifentanil-induced postoperative hyperalgesia by regulating NMDA receptor NR1 subunit phosphorylation and GLT-1 express	11
Mechanical and cold polymodality coexist in tactile peripheral afferents, and it’s not mediated by TRPM8	10
Depression and anxiety in Chinese patients hospitalized with primary headache: A cross-sectional multicenter study	10
Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage	10
Histamine H4 receptor and TRPV1 mediate itch induced by cadaverine, a metabolite of the microbiome	10
Contribution of immune cells to cancer-related neuropathic pain: An updated review	10
Circadian gene NPAS2 modulates pain sensitization in CFA-induced inflammatory pain model	10
Effects on low threshold mechanoreceptors in whisker hair follicles by 5-HT, Cd²⁺, tetraethylammonium, 4-aminopyridine, and Ba²⁺	9
Epigenetic age predictors in community-dwelling adults with high impact knee pain	9
Exploring novel non-opioid pathways and therapeutics for pain modulation	9
RETRACTED: Activation of the P2X7 receptor in the dental pulp tissue contributes to the pain in rats with acute pulpitis	9
Protectin D1 ameliorates non-compressive lumbar disc herniation through SIRT1-mediated CGRP signaling	9
The analgesic effects of β-elemene in rats with neuropathic pain by inhibition of spinal astrocytic ERK activation	9
TRIM14-NF-κB pathway in the anterior cingulate cortex modulates comorbid depressive symptoms in chronic pain	9
The effects of chronic high-dose morphine on microgliosis and the microglial transcriptome in rat spinal cord	8
Sub-anaesthetic dose of propofol attenuates mechanical allodynia in chronic post-ischaemic pain via regulation of PTEN/PI3K/IL-6 signalling	8
Reduced capsaicin-induced mechanical allodynia and neuronal responses in the dorsal root ganglion in the presence of protein tyrosine phosphatase non-receptor type 6 overexpression	8
Sudan Black B treatment uncovers the distribution of angiotensin-converting enzyme2 in nociceptors	7
Understanding the kynurenine pathway: A narrative review on its impact across chronic pain conditions	7
Effects of Fu’s subcutaneous needling on mitochondrial structure and function in rats with sciatica	7
Silent synapses in pain-related anterior cingulate cortex	7
Analgesia and silymarin: What are the opportunities and challenges?	7
AMPAkines have site-specific analgesic effects in the cortex	7
Spinal 5-HT_2A receptor is involved in electroacupuncture inhibition of chronic pain	7
Activation of cyclin-dependent kinase 5 broadens action potentials in human sensory neurons	7
Targeting Vascular endothelial growth factor A with soluble vascular endothelial growth factor receptor 1 ameliorates nerve injury-induced neuropathic pain	7
Mitochondrial transplantation attenuates traumatic neuropathic pain, neuroinflammation, and apoptosis in rats with nerve root ligation	7
Involvement of interferon gamma signaling in spinal trigeminal caudal subnucleus astrocyte in orofacial neuropathic pain in rats with infraorbital nerve injury	7