OOIR: Observatory of International Research

Papers

(The TQCC of Molecular Pain is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Compartmentalized primary cultures of dorsal root ganglion neurons to model peripheral pathophysiological conditions	119
T-type Ca ²⁺ channels play a dual role in modulating the excitability of dorsal root ganglia neurons	62
Znhit1 alleviates nitroglycerin-induced hyperalgesia in migraine mice via the inhibition of NOD-like receptor signaling pathway	37
Acute pulpitis promotes purinergic signaling to induce pain in rats via P38MAPK/NF-κB signaling pathway	34
Neural adaptation of the reward system in primary dysmenorrhea	32
Viral vector-mediated interleukin 10 for gene therapy on chronic pain	26
Analgesic effect of gastrin-releasing peptide in the dorsal horn	26
Amino acid transporter SLC38A3 mediates bone cancer pain in rats via the PI3K/AKT/TRPV1 signaling pathway	26
Effects of pain in lumbosacral stenosis and lifestyle-related factors on brain-derived neurotrophic factor expression profiles	24
Administration of 2-deoxy-D-glucose alleviates cancer-induced bone pain by suppressing microglial polarization to the M1 phenotype and neuroinflammation	24
Long-term effects on functional brain networks in adolescents treated for lumbar disc herniation	23
TLR3 mediates central sensitization in a chronic migraine model induced by repeated nitroglycerin through the ERK signaling pathway	22
RIPK3 regulates microglial polarization through the TLR4/MyD88 pathway in neuropathic pain	22
Characterization of excitatory synaptic transmission in the retrosplenial cortex of adult mice	22
Recruitment of cortical silent responses by forskolin in the anterior cingulate cortex of adult mice	19
Phenotypic screen identifies the natural product silymarin as a novel anti-inflammatory analgesic	19
EXPRESS: Evaluation of Stress Biomarkers in individuals with Migraine or Tension-Type headached before and after Botulinum Toxin Injection	18
Caffeic acid phenethyl ester attenuates inflammatory pain through promoting spinal microglial M1-to-M2 polarization by suppressing the PI3K/Akt/NF-κB pathway and attenuating peripheral inflammation	18
Probing pain aversion in rats with the “Heat Escape Threshold” paradigm	18
ARG1 and CXCL2 are potential biomarkers target for psoriasis patients	17
Resolvin D1 attenuates mechanical allodynia after burn injury: Involvement of spinal glia, p38 mitogen-activated protein kinase, and brain-derived neurotrophic factor/tropomyosin-related kinase B sign	16
Unraveling the PVN ^Glu -PrL ^Glu circuit: A new frontier in chronic pain management for lumbar disc	16
Piezo1-mediated neuroexcitation via collaboration with KCa1.1 and Nav1.9 currents in myelinated Ah-type of trigeminal ganglion neurons in rats: Mechanistic insights with sex-specific effects	15
A note on estimating absolute cytosolic Ca ²⁺ concentration in sensory neurons using a single wavelength Ca ²⁺	15
Upregulation of KDM6B in the anterior cingulate cortex contributes to neonatal maternal deprivation-induced chronic visceral pain in mice	15

CGRP expression and signaling sensitization in a mouse model of chronic oxaliplatin-induced peripheral neuropathy	14
T cells modulate the development and maintenance of painful paclitaxel-induced peripheral neuropathy in RNU rats	14
Methylglyoxal activates transient receptor potential A1/V1 via reactive oxygen species in the spinal dorsal horn	14
Electroacupuncture at Zusanli (ST36) alleviates paclitaxel-induced neuropathic pain in rats via regulating TLR4 signaling pathway in the spinal cord	13
Pain and aging: A unique challenge in neuroinflammation and behavior	13
The role of visual expectations in acupuncture analgesia: A quantitative electroencephalography study	12
Persistent inflammatory pain is linked with anxiety-like behaviors, increased blood corticosterone, and reduced global DNA methylation in the rat amygdala	12
Analyzing Substance Levels and Pain Perception in Painless Labor: The Impact of Spinal Epidural Analgesia	12
Inflammation in pathogenesis of chronic pain: Foe and friend	12
Characteristics of immune cells and causal relationship with chondromalacia: A two-sample, bidirectional mendelian randomization study	12
miRNA-let7b5p alleviates visceral hypersensitivity by inhibiting the activation of spinal microglial in male IBS-like rats	12
miR-155-5p in the spinal cord regulates hypersensitivity in a rat model of bone cancer pain	11
The holistic approach to the CHRNA7 gene, hsa-miR-3158-5p , and 15q13.3 hotspot CNVs in migraineurs	11
Spinal NLRP3 inflammasome activation mediates IL-1β release and contributes to remifentanil-induced postoperative hyperalgesia by regulating NMDA receptor NR1 subunit phosphorylation and GLT-1 express	11
Mechanical and cold polymodality coexist in tactile peripheral afferents, and it’s not mediated by TRPM8	11
Meningeal macrophages mask incision pain sensitization in male rats	11
Depression and anxiety in Chinese patients hospitalized with primary headache: A cross-sectional multicenter study	10
Rac1/PAK1 signaling contributes to bone cancer pain by Regulation dendritic spine remodeling in rats	10
Application of XGBoost in the prediction of acute postoperative pain after major noncardiac surgery in older patients	10
Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage	10
Spinal HDAC6 mediates nociceptive behaviors induced by chronic constriction injury via neuronal activation and neuroinflammation	10
Spinal overexpression of CAPN1 in CaMKII neurons mediates paclitaxel-induced neuropathic pain via NCS-1-TRPV4 signaling	9
TRIM14-NF-κB pathway in the anterior cingulate cortex modulates comorbid depressive symptoms in chronic pain	9
RETRACTED: Activation of the P2X7 receptor in the dental pulp tissue contributes to the pain in rats with acute pulpitis	9
Contribution of immune cells to cancer-related neuropathic pain: An updated review	9
Mechanism of asiatic acid in relieving psoriasis by modulating the PI3K/Akt/NF-κB pathway and NLRP3 inflammasome	9
Histamine H4 receptor and TRPV1 mediate itch induced by cadaverine, a metabolite of the microbiome	9
Identification of acetylation-related molecular signatures in knee osteoarthritis patients with significant response to warm-needle acupuncture using machine-learning approaches	9
Epigenetic age predictors in community-dwelling adults with high impact knee pain	9
Reduced capsaicin-induced mechanical allodynia and neuronal responses in the dorsal root ganglion in the presence of protein tyrosine phosphatase non-receptor type 6 overexpression	8
Redox-associated gene and microRNA signatures in degenerative intervertebral disc disease	8
Sub-anaesthetic dose of propofol attenuates mechanical allodynia in chronic post-ischaemic pain via regulation of PTEN/PI3K/IL-6 signalling	8
The effects of chronic high-dose morphine on microgliosis and the microglial transcriptome in rat spinal cord	8
The analgesic effects of β-elemene in rats with neuropathic pain by inhibition of spinal astrocytic ERK activation	8
Exploring frequency-dependent and dynamic changes in brain connectivity of chronic back pain patients using degree centrality analysis	8
EXPRESS: Serum miR-145-5p as a Predictive Biomarker for Postoperative Pain after Percutaneous Kyphoplasty	8
Circadian gene NPAS2 modulates pain sensitization in CFA-induced inflammatory pain model	8
Silent synapses in pain-related anterior cingulate cortex	7
Protectin D1 ameliorates non-compressive lumbar disc herniation through SIRT1-mediated CGRP signaling	7
Analgesia and silymarin: What are the opportunities and challenges?	7
AMPAkines have site-specific analgesic effects in the cortex	7
Exploring novel non-opioid pathways and therapeutics for pain modulation	7
Involvement of interferon gamma signaling in spinal trigeminal caudal subnucleus astrocyte in orofacial neuropathic pain in rats with infraorbital nerve injury	7
Understanding the kynurenine pathway: A narrative review on its impact across chronic pain conditions	7
Activation of cyclin-dependent kinase 5 broadens action potentials in human sensory neurons	7
Targeting Vascular endothelial growth factor A with soluble vascular endothelial growth factor receptor 1 ameliorates nerve injury-induced neuropathic pain	7
EXPRESS: A Road to Recovery: Transient Receptor Potential (TRP) Channels as Therapeutic Avenues for Spinal Cord Injury	7