Biology Direct

Article	Citations
USP5 knockdown alleviates lung cancer progression via activating PARP1-mediated mTOR signaling pathway	75
MINPP1 promotes ferroptosis in HBV-related hepatocellular carcinoma by regulating CTSB K33-linked deubiquitination via ZRANB1	58
Exploring the role of GhN/AINV23: implications for plant growth, development, and drought tolerance	52
Circ_0002669 promotes osteosarcoma tumorigenesis through directly binding to MYCBP and sponging miR-889-3p	47
DEPTOR attenuates asthma progression by suppressing endoplasmic reticulum stress through SOD1	43
Long-term longitudinal study on swine VML model	42
Moving biology direct towards a new dimension	38
Wandering about allostery	35
Deciphering the role of SAMHD1 in endometrial cancer progression	33
Functional and structural characterization of the human indolethylamine N-methyltransferase through fluorometric, thermal and computational docking analyses	33
Comparative analysis of human Mesenchymal Stromal Cells from Adipose Tissue and Dental Pulp: phenotypic characterization and secretome profiling	32
NID1 promotes laryngeal cancer stemness via activating WNT pathway	31
Dualistic role of ZEB1 and ZEB2 in tumor progression	30
Effect of pesticides on breast cancer tumor	29
Equol exerts anti-tumor effects on choriocarcinoma cells by promoting TRIM21-mediated ubiquitination of ANXA2	26
Epigenetic mechanism of RBM15 in affecting cisplatin resistance in laryngeal carcinoma cells by regulating ferroptosis	26
Prostatitis, benign prostatic hyperplasia, and prostate cancer: a bidirectional Mendelian randomization study and clinical implications for these patients’ populations	25
Molecular mechanisms of efferocytosis imbalance in the idiopathic pulmonary fibrosis microenvironment: from gene screening to dynamic regulation analysis	25
RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment	25
Single-cell RNA sequencing reveals the critical role of alternative splicing in cattle testicular spermatagonia	24
Identification of a prognostic cuproptosis-related signature in hepatocellular carcinoma	23
ZNF330/NOA36 interacts with HSPA1 and HSPA8 and modulates cell cycle and proliferation in response to heat shock in HEK293 cells	22
Neuregulin-4 protects cardiomyocytes against high-glucose-induced ferroptosis via the AMPK/NRF2 signalling pathway	22
An exploration into the diagnostic capabilities of microRNAs for myocardial infarction using machine learning	22
Conventional type 1 dendritic cells (cDC1) in cancer immunity	21

DTX2 promotes glioma development via regulation of HLTF	21
The deubiquitinating protein OTUD6B promotes lung adenocarcinoma progression by stabilizing RIPK1	20
ARMCX1 inhibits lung adenocarcinoma progression by recruiting FBXW7 for c-Myc degradation	20
Lactobacillus reuteri mitigates hepatic ischemia/reperfusion injury by modulating gut microbiota and metabolism through the Nrf2/HO-1 signaling	19
Circulating extracellular vesicles regulate ELAVL1 by delivering miR-133a-3p which affecting NLRP3 mRNA stability inhibiting PANoptosome formation	19
Biochemical characterization of the feedforward loop between CDK1 and FOXM1 in epidermal stem cells	19
Lipidome atlas of p53 mutant variants in pancreatic cancer	18
Martin Karplus (1930–2024)	18
Exploring the molecular mechanism of estrogen therapy effectiveness after TCRA in IUA patients at single-cell level	18
M2 macrophage-derived exosomal miR-193b-3p promotes progression and glutamine uptake of pancreatic cancer by targeting TRIM62	18
Correction: Affibodies as valuable tool to prevent β2m aggregation under lysosomal-like conditions	17
The role of SH3RF2 in lung squamous cell carcinoma and M2 polarization: insights into LZTS2 ubiquitination	16
RCC2 promotes prostate cancer cell proliferation and migration through Hh/GLI1 signaling pathway and cancer stem-like cells	16
N6-methyladenosine-mediated SH3BP5-AS1 upregulation promotes GEM chemoresistance in pancreatic cancer by activating the Wnt signaling pathway	16
Identification of druggable targets in acute kidney injury by proteome- and transcriptome-wide Mendelian randomization and bioinformatics analysis	16
FXR1 associates with and degrades PDZK1IP1 and ATOH8 mRNAs and promotes esophageal cancer progression	16
A multi-omics exploration of PPARG activation in colon cancer: kinases featuring a PPRE sequence within regulatory regions	15
Correction: High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinoma	15
Spatiotemporal dynamics of neuronal subtypes and their interactions with glia following intracortical electrode implantation	15
The RRP9-JUN axis promotes breast cancer progression via the AKT signalling pathway	15
Exploring the role of oxidative stress in carotid atherosclerosis: insights from transcriptomic data and single-cell sequencing combined with machine learning	15
p53 regulates expression of nuclear envelope components in cancer cells	14
ILC1-derived IFN-γ regulates macrophage activation in colon cancer	14
Loss of the centrosomal protein ALMS1 alters lipid metabolism and the regulation of extracellular matrix-related processes	14
Machine learning-driven estimation of mutational burden highlights DNAH5 as a prognostic marker in colorectal cancer	14
MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis	14
Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies	14
Long-range enhancement of N501Y-endowed mouse infectivity of SARS-CoV-2 by the non-RBD mutations of Ins215KLRS and H655Y	14
LncRNA MIR205HG accelerates cell proliferation, migration and invasion in hepatoblastoma through the activation of MAPK signaling pathway and PI3K/AKT signaling pathway	13
BMC Caller: a webtool to identify and analyze bacterial microcompartment types in sequence data	13
Colon cancer exosome-associated HSP90B1 initiates pre-metastatic niche formation in the liver by polarizing M1 macrophage into M2 phenotype	13
The role of endothelial cell-related gene COL1A1 in prostate cancer diagnosis and immunotherapy: insights from machine learning and single-cell analysis	13
Plasma membrane calcium ATPases and cerebellar pathology: what’s the role in the ataxia?	13
USP44 regulates HEXIM1 stability to inhibit tumorigenesis and metastasis of oral squamous cell carcinoma	13
Artificial genetic polymers against human pathologies	12
Tissue-specific roles of peroxisomes revealed by expression meta-analysis	12
In vitro synergistic effect of AXL, FAK and ErbB receptors inhibitors for head and neck cancer	12
CLOCK-mediated acetylation of NF-κB p65 drives immune evasion in breast cancer	12
Integrative genomics unveils basement membrane-related diagnostic markers and therapeutic targets in esophageal squamous cell carcinoma	12
Eraldo Antonini Lectures, 1983–2019	12
Indispensable role of AcrEF in modulating Salmonella virulence and disrupting host tight junctions to facilitate paracellular entry and invasion	12
Shaping root architecture: towards understanding the mechanisms involved in lateral root development	12
Single-cell transcriptomic profiling unveils insights into ovarian fibrosis in obese mice	12
RPL35A promotes the progression of cholangiocarcinoma by mediating HSPA8 ubiquitination	12
Lactobacillus rhamnosus GG ameliorates radiation-induced lung fibrosis via lncRNASNHG17/PTBP1/NICD axis modulation	12
Autophagy inhibition potentiates anti-cancer activity of Sunitinib in kidney cancer cells	12
Dysregulation and antimetastatic function of circLRIG1 modulated by miR-214-3p/LRIG1 axis in bladder carcinoma	12
Dual-labeled nanoparticles based on small extracellular vesicles for tumor detection	12
Ti3C2 (MXene) nanosheets disrupt spermatogenesis in male mice mediated by the ATM/p53 signaling pathway	11
SPI1 upregulated LILRB2 to enhance the immunosuppressive phenotype of LPS-tolerant macrophages by inhibiting TLR8-mediated MyD88/NF-κB signaling	11

Platelet-activating factor induces ferroptosis by binding to ATF3 and inhibiting the SLC7A11/GPX4 axis to suppress the progression of endometrial carcinoma	11
miPEP31 alleviates sepsis development by regulating Chi3l1-dependent macrophage polarization	11
Mir-338-3p targeting THBS1 attenuates glioma progression by inhibiting the PI3K/Akt pathway	11
Alpha-actnin-4 (ACTN4) selectively affects the DNA double-strand breaks repair in non-small lung carcinoma cells	11
Differential adaptive RNA editing signals between insects and plants revealed by a new measurement termed haplotype diversity	11
Image-based modeling of vascular organization to evaluate anti-angiogenic therapy	10
Biological roles of RNA m7G modification and its implications in cancer	10
Sorafenib-induced macrophage extracellular traps via ARHGDIG/IL4/PADI4 axis confer drug resistance through inhibiting ferroptosis in hepatocellular carcinoma	10
RARRES1 inhibits hepatocellular carcinoma progression and increases its sensitivity to lenvatinib through interaction with SPINK2	10
Inhibition of PRC1 elicits immunogenic cell death by triggering ROS-dependent ER stress in colorectal cancer via the Wnt/β-catenin signaling pathway	10
HOXB4/METTL7B cascade mediates malignant phenotypes of hepatocellular carcinoma through TKT m6A modification	10
The oncogenic role and regulatory mechanism of PGK1 in human non-small cell lung cancer	10
Probing pathways by which rhynchophylline modifies sleep using spatial transcriptomics	10
Estrogen receptor alpha dynamics and plasticity during endocrine resistance	10
Mir-421 and mir-550a-1 are potential prognostic markers in esophageal adenocarcinoma	10
A functional approach to homeostatic regulation	10
miR-155 mediated regulation of PKG1 and its implications on cell invasion, migration, and apoptosis in preeclampsia through NF-κB pathway	9
Integrating machine learning models with multi-omics analysis to decipher the prognostic significance of mitotic catastrophe heterogeneity in bladder cancer	9
HMGA1 promotes the progression of lung adenocarcinoma through the STAT1-mediated transcriptional activation of DDAH1	9
Targeting SOX4/PCK2 signaling suppresses neuroendocrine trans-differentiation of castration-resistant prostate cancer	9
Correction: Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblasts	9
Evolution of cell therapies derived from adipose tissue: historical perspectives, current development trends and future directions	9
Necroptosis-driven T cell activation promotes IL-6-mediated PD-L1 upregulation in cholangiocarcinoma cells: IL-6 gene signature as a biomarker for chemo-immunotherapy response	9
Reprogramming hematopoietic stem cell metabolism in lung cancer: glycolysis, oxidative phosphorylation, and the role of 2-DG	9
Correction: IPSC derived cardiac fibroblasts of DMD patients show compromised actin microfilaments, metabolic shift and pro-fibrotic phenotype	9
Spleen granulopoiesis in psoriasis immune microenvironment aggravates psoriasis via IL-6/P-STAT3 signaling	9
The role of LINC01419 in regulating the cell stemness in lung adenocarcinoma through recruiting EZH2 and regulating FBP1 expression	9
Glucose deprivation-induced disulfidptosis in human nucleus pulposus cells: a novel pathological mechanism of intervertebral disc degeneration	9
Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblasts	9
LncRNA5251 inhibits spermatogenesis via modification of cell-cell junctions	9
Upregulation of long intergenic non-coding RNA LINC00326 inhibits non-small cell lung carcinoma progression by blocking Wnt/β-catenin pathway through modulating the miR-657/dickkopf WNT signaling path	8
Construction of a prognostic model based on disulfidptosis-related genes and identification of CCNA2 as a novel biomarker for hepatocellular carcinoma	8
cGAS-STING targeting offers therapy choice in lung diseases	8
ADSC-derived exosomes attenuate myocardial infarction injury by promoting miR-205-mediated cardiac angiogenesis	8
Identification of fatty acid metabolism-related lncRNAs in the prognosis and immune microenvironment of colon adenocarcinoma	8
m6A methylation-mediated lncRNA RNF144A-AS1 promotes hepatocellular carcinoma progression through the miR-1301-3p/RNF38 pathway	8
Identification of M2 macrophage-related genes associated with diffuse large B-cell lymphoma via bioinformatics and machine learning approaches	8
Circular RNA hsa_circ_0067842 facilitates tumor metastasis and immune escape in breast cancer through HuR/CMTM6/PD-L1 axis	8
Host-mediated RNA editing in viruses	8
Single-cell transcriptomics reveals cellular heterogeneity and macrophage-to-mesenchymal transition in bicuspid calcific aortic valve disease	8
In silico optimization of RNA–protein interactions for CRISPR-Cas13-based antimicrobials	8
Quinolinic acid impairs mitophagy promoting microglia senescence and poor healthspan in C. elegans: a mechanism of impaired aging process	8
KIF4A in disease pathogenesis and therapeutics: from molecular mechanisms to clinical translation	8
Single-cell RNA sequencing reveals a new mechanism of endothelial cell heterogeneity and healing in diabetic foot ulcers	8
Comprehensive pan-cancer analysis indicates UCHL5 as a novel cancer biomarker and promotes cervical cancer progression through the Wnt signaling pathway	8
LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis	7
METTL3-induced lncRNA GBAP1 promotes hepatocellular carcinoma progression by activating BMP/SMAD pathway	7
Integrating Circle-Seq with transcriptomics reveals genome-wide characterization of extrachromosomal circular DNA for dilated cardiomyopathy	7
Prognostic model integrating histology, systemic inflammation, and recurrence status predicts immunotherapy response in advanced non-small-cell lung cancer patients	7
Fraxinellone-mediated targeting of cathepsin B leakage from lysosomes induces ferroptosis in fibroblasts to inhibit hypertrophic scar formation	7
PNSC928, a plant-derived compound, specifically disrupts CtBP2-p300 interaction and reduces inflammation in mice with acute respiratory distress syndrome	7
Exploring the association between osteoporosis and kidney stones: a clinical to mechanistic translational study based on big data and bioinformatics	7
m6A-mediated upregulation of LINC01003 regulates cell migration by targeting the CAV1/FAK signaling pathway in glioma	7
Elevated SREBP1 accelerates the initiation and growth of pancreatic cancer by targeting SOX9	7
Proteomics and digital subtraction angiography approaches reveal CDH18 as a potential target for therapy of moyamoya disease	7
Affibodies as valuable tool to prevent β2m aggregation under lysosomal-like conditions	7
The CXCR3/PLC/IP3-IP3R axis is responsible for the ignition of UPR in intestinal epithelial cells exposed to gliadin peptide, during the onset of celiac disease	7
Ecological determinants of altruism in prokaryote antivirus defense	7
Spinal apolipoprotein E is involved in inflammatory pain via regulating lipid metabolism and glial activation in the spinal dorsal horn	7
Unraveling the oxidative stress landscape in diabetic foot ulcers: insights from bulk RNA and single-cell RNA sequencing data	7
METTL3 in cancer-associated fibroblasts-derived exosomes promotes the proliferation and metastasis and suppresses ferroptosis in colorectal cancer by eliciting ACSL3 m6A modification	7
Antitumoral effects of Bortezomib in malignant mesothelioma: evidence of mild endoplasmic reticulum stress in vitro and activation of T cell response in vivo	7
Mammalian enabled protein enhances tamoxifen sensitivity of the hormone receptor-positive breast cancer patients by suppressing the AKT signaling pathway	7
Deep learning-assisted high-content screening identifies isoliquiritigenin as an inhibitor of DNA double-strand breaks for preventing doxorubicin-induced cardiotoxicity	7
Long-read assembly of major histocompatibility complex and killer cell immunoglobulin-like receptor genome regions in cynomolgus macaque	7
Did the early full genome sequencing of yeast boost gene function discovery?	7
Unveiling the molecular profile of a prostate carcinoma: implications for personalized medicine	7
Genomic characteristics and evolution of Multicentric Esophageal and gastric Cardiac Cancer	7
Loss of AMPK activity induces organelle dysfunction and oxidative stress during oocyte aging	7
AQP5 trafficking is regulated by its C-terminal tail and interaction with prolactin-inducible protein	7
Ultrastructural studies distinguish skin diversities among Galápagos iguanas	7
TIMM8B promotes oxidative phosphorylation and glycolysis by inhibiting the mtROS/ASK1/JNK signaling pathway in ovarian cancer	7
Autophagy is influenced by vitamin D3 level in people with HIV-1	7
PLAU promotes growth and attenuates cisplatin chemosensitivity in ARID1A-depleted non-small cell lung cancer through interaction with TM4SF1	6
Lysine-specific methyltransferase Set7/9 in stemness, differentiation, and development	6
Efficient DNA-free co-targeting of nuclear genes in Chlamydomonas reinhardtii	6
scE2EGAE: enhancing single-cell RNA-Seq data analysis through an end-to-end cell-graph-learnable graph autoencoder with differentiable edge sampling	6
GPR137 inactivates Hippo signaling to promote gastric cancer cell malignancy	6
A glutamine metabolish-associated prognostic model to predict prognosis and therapeutic responses of hepatocellular carcinoma	6
Identification of novel snoRNA-based biomarkers for clear cell renal cell carcinoma from urine-derived extracellular vesicles	6

Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism	6
Integrating multi-layered biological priors to improve genomic prediction accuracy in beef cattle	6
p53-driven lipidome influences non-cell-autonomous lysophospholipids in pancreatic cancer	6
Phosphodiesterase type 5 inhibitor tadalafil reduces prostatic fibrosis via MiR-3126-3p/FGF9 axis in benign prostatic hyperplasia	6
Horizontal transfer of matrix metalloproteinase genes links early animal and microbial evolution	6
ACSM5 inhibits ligamentum flavum hypertrophy by regulating lipid accumulation mediated by FABP4/PPAR signaling pathway	6
Vemurafenib induces senescence in acute myeloid leukemia and myelodysplastic syndrome by activating the HIPPO signaling pathway: implications for potential targeted therapy	6
Identifying the driver miRNAs with somatic copy number alterations driving dysregulated ceRNA networks in cancers	6
Sigma-1 receptor activation attenuates DOX-induced cardiotoxicity by alleviating endoplasmic reticulum stress and mitochondrial calcium overload via PERK and IP3R-VDAC1-MCU signaling pathways	6
CircRNA_15430 reduced by Helicobacter pylori infection and suppressed gastric cancer progression via miR-382-5p/ZCCHC14 axis	5
Coordinating energy metabolism and signaling pathways in epithelial self-renewal and differentiation	5
Are prime numbers special? Insights from the life sciences	5
Early-stage administration of hydroxytyrosol extends lifespan and delays aging in C. elegans	5
Hypoxia-induced activation of HIF-1alpha/IL-1beta axis in microglia promotes glioma progression via NF-κB-mediated upregulation of heparanase expression	5
BRD4 sustains p63 transcriptional program in keratinocytes	5
Analysis of lineage-specific protein family variability in prokaryotes combined with evolutionary reconstructions	5
Prognostic model of lung adenocarcinoma based on disulfidptosis-related genes and analysis of in vitro cell experiments for PPP1R14B in the model	5
Utilizing liquid-liquid biopolymer regulators to predict the prognosis and drug sensitivity of hepatocellular carcinoma	5
Overexpression of ZNF488 supports pancreatic cancer cell proliferation and tumorigenesis through inhibition of ferroptosis via regulating SCD1-mediated unsaturated fatty acid metabolism	5
Machine learning model reveals the role of angiogenesis and EMT genes in glioma patient prognosis and immunotherapy	5
Deubiquitination of DNM1L by USP3 triggers the development and metastasis of gallbladder carcinoma	5
Valentina Tassinari, the legacy of a young scientist	5
Integrated machine learning reveals the role of tryptophan metabolism in clear cell renal cell carcinoma and its association with patient prognosis	5
Functional genomic imaging (FGI), a virtual tool for visualization of functional gene expression modules in heterogeneous tumor samples	5
MIR194-2HG, a miRNA host gene activated by HNF4A, inhibits gastric cancer by regulating microRNA biogenesis	5
Acetylation- and ubiquitination-regulated SFMBT2 acts as a tumor suppressor in clear cell renal cell carcinoma	5
Extracellular vesicles derived from different tissues attenuate cardiac dysfunction in murine MI models	5
Regulating ferroptosis by non-coding RNAs in hepatocellular carcinoma	5
miR-210 is essential to retinal homeostasis in fruit flies and mice	5
Dynamic expression of IGFBP3 modulate dual actions of mineralization micro-environment during tooth development via Wnt/beta-catenin signaling pathway	5
Active enhancers: recent research advances and insights into disease	4
GALNT9 enrichment attenuates MPP+-induced cytotoxicity by ameliorating protein aggregations containing α-synuclein and mitochondrial dysfunction	4
USP40 promotes hepatocellular carcinoma cell proliferation, migration and stemness by deubiquitinating and stabilizing Claudin1	4
C-MYC-activated lncRNA SNHG20 accelerates the proliferation of diffuse large B cell lymphoma via USP14-mediated deubiquitination of β-catenin	4
Human lung cancer-derived mesenchymal stem cells promote tumor growth and immunosuppression	4
Evolution of retrocopies in the context of HUSH silencing	4
YTHDC1 aggravates high glucose-induced retinal vascular endothelial cell injury via m6A modification of CDK6	4
Plasma N-Glycoproteomics in monozygotic twin pairs discordant for body mass index reveals an obesity signature related to inflammation and iron metabolism	4
OTUD5 promotes the growth of hepatocellular carcinoma by deubiquitinating and stabilizing SLC38A1	4
Breaking barriers: improving time and space resolution of arbuscular mycorrhizal symbiosis with single-cell sequencing approaches	4
Combined treatment of nerve growth factor and transcranical direct current stimulations to improve outcome in children with vegetative state after out-of-hospital cardiac arrest	4
H3K27ac-activated EGFR-AS1 promotes cell growth in cervical cancer through ACTN4-mediated WNT pathway	4
Gliadin-dependent UPR induction directly triggers the expression of TG2 and pro-inflammatory cytokines, dysregulates intestinal permeability, and reduces CFTR expression in intestinal epithelial cells	4
Boanmycin overcomes bortezomib resistance by inducing DNA damage and endoplasmic reticulum functional impairment in multiple myeloma	4
LINC01094 promotes gastric cancer through dual targeting of CDKN1A by directly binding RBMS2 and HDAC1	4
Correction: METTL3-induced lncRNA GBAP1 promotes hepatocellular carcinoma progression by activating BMP/SMAD pathway	4
Exosomes containing circSCP2 in colorectal cancer promote metastasis via sponging miR-92a-1-5p and interacting with PTBP1 to stabilize IGF2BP1	4
Transcriptional diversity in specific synaptic gene sets discriminates cortical neuronal identity	4
Ubiquitin recruiting chimera: more than just a PROTAC	4
Total network controllability analysis discovers explainable drugs for Covid-19 treatment	4
Correction: ILC1-derived IFN-γ regulates macrophage activation in colon cancer	4
NAMPT modulates muscle fiber type transition in PAD myopathy via the cGMP-PKG signaling pathway	4
LINC00885 promotes cervical cancer progression through sponging miR-3150b-3p and upregulating BAZ2A	4
Large-scale bulk and single-cell RNA sequencing combined with machine learning reveals glioblastoma-associated neutrophil heterogeneity and establishes a VEGFA+ neutrophil prognostic model	4
Differential growth and flowering capacity of tulip bulbs and the potential involvement of PHOSPHATIDYLETHANOLAMINE-BINDING PROTEINS (PEBPs)	4
Topological determinants in protein folding dynamics: a comparative analysis of metamorphic proteins	4
ZNF692 promotes osteosarcoma cell proliferation, migration, and invasion through TNK2-mediated activation of the MEK/ERK pathway	4
E3 ligase HERC5-catalyzed UGDH isgylation promotes SNAI1-mediated tumor metastasis and cisplatin resistance in oral squamous cell carcinoma	4
Disulfidptosis signature predicts immune microenvironment and prognosis of gastric cancer	4
Identification of metastasis-related genes for predicting prostate cancer diagnosis, metastasis and immunotherapy drug candidates using machine learning approaches	4