Biology Direct

Article	Citations
Sigma-1 receptor activation attenuates DOX-induced cardiotoxicity by alleviating endoplasmic reticulum stress and mitochondrial calcium overload via PERK and IP3R-VDAC1-MCU signaling pathways	68
New hope for the world cancer day	52
Bi-targeting of thioredoxin 1 and telomerase by thiotert promotes cell death of myelodysplastic syndromes and lymphoma	51
PSMD3-ILF3 signaling cascade drives lung cancer cell proliferation and migration	46
Evolution of retrocopies in the context of HUSH silencing	40
Disulfidptosis-associated LncRNA signature predicts prognosis and immune response in kidney renal clear cell carcinoma	39
Inhibition of TRAF6 improves hyperlipidemic acute pancreatitis by alleviating pyroptosis in vitro and in vivo rat models	34
Mammalian enabled protein enhances tamoxifen sensitivity of the hormone receptor-positive breast cancer patients by suppressing the AKT signaling pathway	34
Comprehensive analysis of mitochondria-related genes indicates that PPP2R2B is a novel biomarker and promotes the progression of bladder cancer via Wnt signaling pathway	32
Ti3C2 (MXene) nanosheets disrupt spermatogenesis in male mice mediated by the ATM/p53 signaling pathway	31
Boanmycin overcomes bortezomib resistance by inducing DNA damage and endoplasmic reticulum functional impairment in multiple myeloma	30
Novel crossover and recombination hotspots massively spread across primate genomes	29
MiR-19b-3p regulated by BC002059/ABHD10 axis promotes cell apoptosis in myocardial infarction	28
Long-read assembly of major histocompatibility complex and killer cell immunoglobulin-like receptor genome regions in cynomolgus macaque	28
Enhanced itaconic acid secretion from macrophages mediates the protection of mesenchymal stem cell-derived exosomes on lipopolysaccharide-induced acute lung injury mice	27
Downregulation of amphiregulin improves cardiac hypertrophy via attenuating oxidative stress and apoptosis	26
DEPTOR attenuates asthma progression by suppressing endoplasmic reticulum stress through SOD1	25
Discovery of potential natural therapeutics targeting cell wall biosynthesis in multidrug-resistant Enterococcus faecalis: a computational perspective	24
Understanding p53 tumour suppressor network	24
Migrasomes, new vescicles as Hansel and Gretel white pebbles?	22
Alpha-actnin-4 (ACTN4) selectively affects the DNA double-strand breaks repair in non-small lung carcinoma cells	21
Rab32 uses its effector reticulon 3L to trigger autophagic degradation of mitochondria-associated membrane (MAM) proteins	21
The antipsychotic medications aripiprazole, brexpiprazole and cariprazine are off-target respiratory chain complex I inhibitors	19
m6A-mediated upregulation of LINC01003 regulates cell migration by targeting the CAV1/FAK signaling pathway in glioma	18
Discovery biomarker to optimize obeticholic acid treatment for non-alcoholic fatty liver disease	18

Nitric oxide-dependent immunosuppressive function of thymus-derived mesenchymal stromal/stem cells	17
Antitumoral effects of Bortezomib in malignant mesothelioma: evidence of mild endoplasmic reticulum stress in vitro and activation of T cell response in vivo	17
Long-term longitudinal study on swine VML model	17
Kruppel-like factor 13 acts as a tumor suppressor in thyroid carcinoma by downregulating IFIT1	17
N6-methyladenosine methyltransferase KIAA1429 promoted ovarian cancer aerobic glycolysis and progression through enhancing ENO1 expression	16
Bcl-B: an “unknown” protein of the Bcl-2 family	16
Identifying the driver miRNAs with somatic copy number alterations driving dysregulated ceRNA networks in cancers	15
Human lung cancer-derived mesenchymal stem cells promote tumor growth and immunosuppression	15
Circ_0002669 promotes osteosarcoma tumorigenesis through directly binding to MYCBP and sponging miR-889-3p	14
Exploring the role of GhN/AINV23: implications for plant growth, development, and drought tolerance	14
Deciphering the impact of MreB on the morphology and pathogenicity of the aquatic pathogen Spiroplasma eriocheiris	13
C-MYC-activated lncRNA SNHG20 accelerates the proliferation of diffuse large B cell lymphoma via USP14-mediated deubiquitination of β-catenin	13
miPEP31 alleviates sepsis development by regulating Chi3l1-dependent macrophage polarization	13
Multiplex antimicrobial activities of the self-assembled amphiphilic polypeptide β nanofiber KF-5 against vaginal pathogens	12
LINC01094 promotes gastric cancer through dual targeting of CDKN1A by directly binding RBMS2 and HDAC1	12
Soft X-ray tomography analysis of mitochondria dynamics in Saccharomyces cerevisiae	12
Exosomes containing circSCP2 in colorectal cancer promote metastasis via sponging miR-92a-1-5p and interacting with PTBP1 to stabilize IGF2BP1	12
Dual-labeled nanoparticles based on small extracellular vesicles for tumor detection	11
Integrating multi-layered biological priors to improve genomic prediction accuracy in beef cattle	11
GPR137 inactivates Hippo signaling to promote gastric cancer cell malignancy	10
Differential growth and flowering capacity of tulip bulbs and the potential involvement of PHOSPHATIDYLETHANOLAMINE-BINDING PROTEINS (PEBPs)	10
Long-term administration of Western diet induced metabolic syndrome in mice and causes cardiac microvascular dysfunction, cardiomyocyte mitochondrial damage, and cardiac remodeling involving caveolae	10
Phosphodiesterase type 5 inhibitor tadalafil reduces prostatic fibrosis via MiR-3126-3p/FGF9 axis in benign prostatic hyperplasia	10
p53-driven lipidome influences non-cell-autonomous lysophospholipids in pancreatic cancer	10
MiR-31-5p regulates the neuroinflammatory response via TRAF6 in neuropathic pain	10
Long non-coding RNA SNHG8 enhances triple-negative breast cancer cell proliferation and migration by regulating the miR-335-5p/PYGO2 axis	9
Exploring the association between osteoporosis and kidney stones: a clinical to mechanistic translational study based on big data and bioinformatics	9
USP5 knockdown alleviates lung cancer progression via activating PARP1-mediated mTOR signaling pathway	9
Differential adaptive RNA editing signals between insects and plants revealed by a new measurement termed haplotype diversity	9
Risk assessment of transgender people: implementation of a demasculinizing–feminizing rodent model including the evaluation of thyroid homeostasis	9
Deciphering the role of SAMHD1 in endometrial cancer progression	9
Biological roles of RNA m7G modification and its implications in cancer	9
Moving biology direct towards a new dimension	9
Mir-338-3p targeting THBS1 attenuates glioma progression by inhibiting the PI3K/Akt pathway	9
A glutamine metabolish-associated prognostic model to predict prognosis and therapeutic responses of hepatocellular carcinoma	8
Doxorubicin PK/PD modeling in multiple myeloma: towards in silico trials	8
HOXB4/METTL7B cascade mediates malignant phenotypes of hepatocellular carcinoma through TKT m6A modification	8
TM4SF1 upregulates MYH9 to activate the NOTCH pathway to promote cancer stemness and lenvatinib resistance in HCC	8
ACSM5 inhibits ligamentum flavum hypertrophy by regulating lipid accumulation mediated by FABP4/PPAR signaling pathway	8
ZFP64 drives glycolysis-mediated stem cell-like properties and tumorigenesis in breast cancer	8
Dualistic role of ZEB1 and ZEB2 in tumor progression	8
Mir-421 and mir-550a-1 are potential prognostic markers in esophageal adenocarcinoma	8
PLAU promotes growth and attenuates cisplatin chemosensitivity in ARID1A-depleted non-small cell lung cancer through interaction with TM4SF1	7
NSUN2 relies on ALYREF to regulate Nrf2-mediated oxidative stress and alleviate Dox-induced liver injury	7
UBE2N promotes cell viability and glycolysis by promoting Axin1 ubiquitination in prostate cancer cells	7
Correction: Comprehensive analysis of mitochondria-related genes indicates that PPP2R2B is a novel biomarker and promotes the progression of bladder cancer via Wnt signaling pathway	7
Matrix Metalloproteinase-9 is associated with tumor microenvironment remodeling of bladder cancer	7
Study on the mechanism of LOXL1-AS1/miR-3614-5p/YY1 signal axis in the malignant phenotype regulation of hepatocellular carcinoma	6
Neuregulin-4 protects cardiomyocytes against high-glucose-induced ferroptosis via the AMPK/NRF2 signalling pathway	6
Wandering about allostery	6

NID1 promotes laryngeal cancer stemness via activating WNT pathway	6
ADAMTS4 exacerbates lung cancer progression via regulating c-Myc protein stability and activating MAPK signaling pathway	6
LINC00909 up-regulates pluripotency factors and promotes cancer stemness and metastasis in pancreatic ductal adenocarcinoma by targeting SMAD4	6
Polymorphism on human aromatase affects protein dynamics and substrate binding: spectroscopic evidence	6
Characterization of the symmetrical benzimidazole twin drug TL1228: the role as viral entry inhibitor for fighting COVID-19	6
RARRES1 inhibits hepatocellular carcinoma progression and increases its sensitivity to lenvatinib through interaction with SPINK2	6
Equol exerts anti-tumor effects on choriocarcinoma cells by promoting TRIM21-mediated ubiquitination of ANXA2	6
CircHIF1A induces cetuximab resistance in colorectal cancer by promoting HIF1α-mediated glycometabolism alteration	6
miR-630 as a therapeutic target in pancreatic cancer stem cells: modulation of the PRKCI-Hedgehog signaling axis	6
Prostatitis, benign prostatic hyperplasia, and prostate cancer: a bidirectional Mendelian randomization study and clinical implications for these patients’ populations	6
Epigenetic mechanism of RBM15 in affecting cisplatin resistance in laryngeal carcinoma cells by regulating ferroptosis	5
USP24-dependent stabilization of Runx2 recruits a p300/NCOA3 complex to transactivate ADAMTS genes and promote degeneration of intervertebral disc in chronic inflammation mice	5
A myeloid leukemia factor homolog is involved in tolerance to stresses and stress-induced protein metabolism in Giardia lamblia	5
Image-based modeling of vascular organization to evaluate anti-angiogenic therapy	5
High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinoma	5
Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism	5
Analysis of lineage-specific protein family variability in prokaryotes combined with evolutionary reconstructions	5
Probing pathways by which rhynchophylline modifies sleep using spatial transcriptomics	5
Analysis of state 1—state 2 transitions by genome editing and complementation reveals a quenching component independent from the formation of PSI-LHCI-LHCII supercomplex in Arabidopsis thaliana	5
Common pathways and functional profiles reveal underlying patterns in Breast, Kidney and Lung cancers	5
NUAK2 and RCan2 participate in the p53 mutant pro-tumorigenic network	5
Principles and biological concepts of heredity before Mendel	5
Dynamic expression of IGFBP3 modulate dual actions of mineralization micro-environment during tooth development via Wnt/beta-catenin signaling pathway	5
TRIM47 drives gastric cancer cell proliferation and invasion by regulating CYLD protein stability	4
Single-molecule long-read methylation profiling reveals regional DNA methylation regulated by Elongator Complex Subunit 2 in Arabidopsis roots experiencing spaceflight	4
Vemurafenib induces senescence in acute myeloid leukemia and myelodysplastic syndrome by activating the HIPPO signaling pathway: implications for potential targeted therapy	4
N6-methyladenosine regulators in hepatocellular carcinoma: investigating the precise definition and clinical applications of biomarkers	4
YTHDF2 promotes anaplastic thyroid cancer progression by activating the DDIT4/AKT/mTOR signaling pathway	4
An integrative in-silico analysis discloses a novel molecular subset of colorectal cancer possibly eligible for immune checkpoint immunotherapy	4
Perilipin 5 deficiency aggravates cardiac hypertrophy by stimulating lactate production in leptin-deficient mice	4
Identification of RNA reads encoding different channels in isolated rat ventricular myocytes and the effect of cell stretching on L-type Ca2+current	4
Circ_MAPK9 promotes STAT3 and LDHA expression by silencing miR-642b-3p and affects the progression of hepatocellular carcinoma	4
RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment	4
Single-cell RNA sequencing reveals the critical role of alternative splicing in cattle testicular spermatagonia	4
The periosteum: a simple tissue with many faces, with special reference to the antler-lineage periostea	4
The oncogenic role and regulatory mechanism of PGK1 in human non-small cell lung cancer	4
LncRNA NORFA promotes the synthesis of estradiol and inhibits the apoptosis of sow ovarian granulosa cells through SF-1/CYP11A1 axis	4
Lysine-specific methyltransferase Set7/9 in stemness, differentiation, and development	4
Identification of novel snoRNA-based biomarkers for clear cell renal cell carcinoma from urine-derived extracellular vesicles	4
Efficient DNA-free co-targeting of nuclear genes in Chlamydomonas reinhardtii	4
Sorafenib-induced macrophage extracellular traps via ARHGDIG/IL4/PADI4 axis confer drug resistance through inhibiting ferroptosis in hepatocellular carcinoma	4
Identification of a prognostic cuproptosis-related signature in hepatocellular carcinoma	4
Pharmacological inhibition of mTORC1 reduces neural death and damage volume after MCAO by modulating microglial reactivity	3
hsa_circ_0020093 suppresses ovarian cancer progression by modulating LRPPRC activity and miR-107/LATS2 signaling	3
PHF5A promotes esophageal squamous cell carcinoma progression via stabilizing VEGFA	3
miR-210 is essential to retinal homeostasis in fruit flies and mice	3
The role of adipose tissue-derived stromal cells, macrophages and bioscaffolds in cutaneous wound repair	3
LINC00858 stabilizes RAN expression and promotes metastasis of gastric cancer	3
Regulating ferroptosis by non-coding RNAs in hepatocellular carcinoma	3
H19X-encoded microRNAs induced by IL-4 in adipocyte precursors regulate proliferation to facilitate differentiation	3
Deciphering MOSPD1’s impact on breast cancer progression and therapeutic response	3
Correction: Risk assessment of transgender people: implementation of a demasculinizing–feminizing rodent model including the evaluation of thyroid homeostasis	3
Alamandine alleviated heart failure and fibrosis in myocardial infarction mice	3
Bone metabolism associated with annual antler regeneration: a deer insight into osteoporosis reversal	3
A functional reference map of the RNF8 interactome in cancer	3
CircRNA_15430 reduced by Helicobacter pylori infection and suppressed gastric cancer progression via miR-382-5p/ZCCHC14 axis	3
MIR194-2HG, a miRNA host gene activated by HNF4A, inhibits gastric cancer by regulating microRNA biogenesis	3
MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression	3
Coordinating energy metabolism and signaling pathways in epithelial self-renewal and differentiation	3
The role of LINC01419 in regulating the cell stemness in lung adenocarcinoma through recruiting EZH2 and regulating FBP1 expression	3
Valentina Tassinari, the legacy of a young scientist	2
Immune-response gene 1 deficiency aggravates inflammation-triggered cardiac dysfunction by inducing M1 macrophage polarization and aggravating Ly6Chigh monocyte recruitment	2
Biochemical characterization of the feedforward loop between CDK1 and FOXM1 in epidermal stem cells	2
Targeting SOX4/PCK2 signaling suppresses neuroendocrine trans-differentiation of castration-resistant prostate cancer	2
Silencing LINC00987 ameliorates adriamycin resistance of acute myeloid leukemia via miR-4458/HMGA2 axis	2
RNF19A inhibits bladder cancer progression by regulating ILK ubiquitination and inactivating the AKT/mTOR signalling pathway	2
DTX2 promotes glioma development via regulation of HLTF	2
Lactobacillus reuteri mitigates hepatic ischemia/reperfusion injury by modulating gut microbiota and metabolism through the Nrf2/HO-1 signaling	2
An exploration into the diagnostic capabilities of microRNAs for myocardial infarction using machine learning	2
Glucose deprivation-induced disulfidptosis in human nucleus pulposus cells: a novel pathological mechanism of intervertebral disc degeneration	2
A comprehensive molecular characterization of a claudin-low luminal B breast tumor	2
miR-155 mediated regulation of PKG1 and its implications on cell invasion, migration, and apoptosis in preeclampsia through NF-κB pathway	2
Transcription factor KLF15 inhibits the proliferation and migration of gastric cancer cells via regulating the TFAP2A-AS1/NISCH axis	2
The impact of androgen-induced translation in modulating androgen receptor activity	2
Reprogramming hematopoietic stem cell metabolism in lung cancer: glycolysis, oxidative phosphorylation, and the role of 2-DG	2
S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) inhibits lung cancer tumorigenesis by regulating cell plasticity	2
Integrated machine learning reveals the role of tryptophan metabolism in clear cell renal cell carcinoma and its association with patient prognosis	2
BRD4 sustains p63 transcriptional program in keratinocytes	2
ALKBH5 activates CEP55 transcription through m6A demethylation in FOXP2 mRNA and expedites cell cycle entry and EMT in ovarian cancer	2
A functional approach to homeostatic regulation	2

Gastrin-related circRNA_0017065 promotes the proliferation and metastasis of colorectal cancer through the miR-3174/RBFOX2 axis	2
Phylogenomic analysis of the diversity of graspetides and proteins involved in their biosynthesis	2
ARMCX1 inhibits lung adenocarcinoma progression by recruiting FBXW7 for c-Myc degradation	2
YY1 mediated DCUN1D5 transcriptional activation promotes triple-negative breast cancer progression by targeting FN1/PI3K/AKT pathway	2
Prognostic and immunological implications of protein kinases in gastric cancer: a focus on hub gene ABL2 and its impact on the polarization of M2 macrophages	1
A genome-wide search of Toll/Interleukin-1 receptor (TIR) domain-containing adapter molecule (TICAM) and their evolutionary divergence from other TIR domain containing proteins	1
c-Jun promotes neuroblastoma cell differentiation by inhibiting APC formation via CDC16 and reduces neuroblastoma malignancy	1
Integrative analysis of the salt stress response in cyanobacteria	1
Circulating extracellular vesicles regulate ELAVL1 by delivering miR-133a-3p which affecting NLRP3 mRNA stability inhibiting PANoptosome formation	1
BRCA1 is involved in sustaining rapid antler growth possibly via balancing of the p53/endoplasmic reticulum stress signaling pathway	1
Functional genomic imaging (FGI), a virtual tool for visualization of functional gene expression modules in heterogeneous tumor samples	1
ZNF330/NOA36 interacts with HSPA1 and HSPA8 and modulates cell cycle and proliferation in response to heat shock in HEK293 cells	1
Construction of a prognostic model based on disulfidptosis-related genes and identification of CCNA2 as a novel biomarker for hepatocellular carcinoma	1
Effect of glycosylation on the affinity of the MTB protein Ag85B for specific antibodies: towards the design of a dual-acting vaccine against tuberculosis	1
Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies	1
Are prime numbers special? Insights from the life sciences	1
In silico optimization of RNA–protein interactions for CRISPR-Cas13-based antimicrobials	1
The deubiquitinating protein OTUD6B promotes lung adenocarcinoma progression by stabilizing RIPK1	1
The p53 family member p73 in the regulation of cell stress response	1
Regulation of renal ischemia-reperfusion injury and tubular epithelial cell ferroptosis by pparγ m6a methylation: mechanisms and therapeutic implications	1
M2 macrophage-derived exosomes promote angiogenesis and improve cardiac function after myocardial infarction	1
M2 macrophage-derived exosomal miR-193b-3p promotes progression and glutamine uptake of pancreatic cancer by targeting TRIM62	1
Methyltransferase-like 7B participates in bladder cancer via ACSL3 m6A modification in a ferroptosis manner	1
An integrated investigation of mitochondrial genes in COPD reveals the causal effect of NDUFS2 by regulating pulmonary macrophages	1
Hypoxia-induced activation of HIF-1alpha/IL-1beta axis in microglia promotes glioma progression via NF-κB-mediated upregulation of heparanase expression	1
Unveiling the unique role of TSPAN7 across tumors: a pan-cancer study incorporating retrospective clinical research and bioinformatic analysis	1
Effect of genotype on individual response to the pharmacological treatment of glaucoma: a systematic review and meta-analysis	1
SUMO3 inhibition by butyric acid suppresses cell viability and glycolysis and promotes gemcitabine antitumor activity in pancreatic cancer	1
Host age structure reshapes parasite symbiosis: collaboration begets pathogens, competition begets virulent mutualists	1
MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis	1
Long non-coding RNAs affecting cell metabolism in cancer	1
Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblasts	1
Characterization of gut microbiota dynamics in an Alzheimer’s disease mouse model through clade-specific marker-based analysis of shotgun metagenomic data	1
Nucleolin in the cell membrane promotes Ang II-mediated VSMC phenotypic switching by regulating the AT1R internalization function	1
Uncovering glycolysis-driven molecular subtypes in diabetic nephropathy: a WGCNA and machine learning approach for diagnostic precision	1
Conventional type 1 dendritic cells (cDC1) in cancer immunity	1
Exploring the molecular mechanism of estrogen therapy effectiveness after TCRA in IUA patients at single-cell level	1
N6-methyladenosine-mediated SH3BP5-AS1 upregulation promotes GEM chemoresistance in pancreatic cancer by activating the Wnt signaling pathway	1
Identification of metastasis-related genes for predicting prostate cancer diagnosis, metastasis and immunotherapy drug candidates using machine learning approaches	1
p53 regulates expression of nuclear envelope components in cancer cells	1
Small extracellular vesicles derived from Nrf2-overexpressing human amniotic mesenchymal stem cells protect against lipopolysaccharide-induced acute lung injury by inhibiting NLRP3	1
About the dark corners in the gene function space of Escherichia coli remaining without illumination by scientific literature	1