Biology Direct

Article	Citations
DEPTOR attenuates asthma progression by suppressing endoplasmic reticulum stress through SOD1	80
Exploring the role of GhN/AINV23: implications for plant growth, development, and drought tolerance	58
Long-term longitudinal study on swine VML model	55
USP5 knockdown alleviates lung cancer progression via activating PARP1-mediated mTOR signaling pathway	53
Circ_0002669 promotes osteosarcoma tumorigenesis through directly binding to MYCBP and sponging miR-889-3p	42
Moving biology direct towards a new dimension	40
Functional and structural characterization of the human indolethylamine N-methyltransferase through fluorometric, thermal and computational docking analyses	39
RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment	38
Epigenetic mechanism of RBM15 in affecting cisplatin resistance in laryngeal carcinoma cells by regulating ferroptosis	37
Single-cell RNA sequencing reveals the critical role of alternative splicing in cattle testicular spermatagonia	36
Wandering about allostery	35
NID1 promotes laryngeal cancer stemness via activating WNT pathway	34
Deciphering the role of SAMHD1 in endometrial cancer progression	33
Neuregulin-4 protects cardiomyocytes against high-glucose-induced ferroptosis via the AMPK/NRF2 signalling pathway	32
Molecular mechanisms of efferocytosis imbalance in the idiopathic pulmonary fibrosis microenvironment: from gene screening to dynamic regulation analysis	30
Prostatitis, benign prostatic hyperplasia, and prostate cancer: a bidirectional Mendelian randomization study and clinical implications for these patients’ populations	30
Dualistic role of ZEB1 and ZEB2 in tumor progression	28
Equol exerts anti-tumor effects on choriocarcinoma cells by promoting TRIM21-mediated ubiquitination of ANXA2	28
Identification of a prognostic cuproptosis-related signature in hepatocellular carcinoma	27
Circulating extracellular vesicles regulate ELAVL1 by delivering miR-133a-3p which affecting NLRP3 mRNA stability inhibiting PANoptosome formation	27
DTX2 promotes glioma development via regulation of HLTF	26
Biochemical characterization of the feedforward loop between CDK1 and FOXM1 in epidermal stem cells	25
M2 macrophage-derived exosomal miR-193b-3p promotes progression and glutamine uptake of pancreatic cancer by targeting TRIM62	23
ARMCX1 inhibits lung adenocarcinoma progression by recruiting FBXW7 for c-Myc degradation	23
An exploration into the diagnostic capabilities of microRNAs for myocardial infarction using machine learning	22

The deubiquitinating protein OTUD6B promotes lung adenocarcinoma progression by stabilizing RIPK1	21
Lactobacillus reuteri mitigates hepatic ischemia/reperfusion injury by modulating gut microbiota and metabolism through the Nrf2/HO-1 signaling	21
The p53 family member p73 in the regulation of cell stress response	19
ZNF330/NOA36 interacts with HSPA1 and HSPA8 and modulates cell cycle and proliferation in response to heat shock in HEK293 cells	19
Conventional type 1 dendritic cells (cDC1) in cancer immunity	18
Exploring the molecular mechanism of estrogen therapy effectiveness after TCRA in IUA patients at single-cell level	18
Martin Karplus (1930–2024)	17
Correction: High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinoma	17
The RRP9-JUN axis promotes breast cancer progression via the AKT signalling pathway	17
Lipidome atlas of p53 mutant variants in pancreatic cancer	16
N6-methyladenosine-mediated SH3BP5-AS1 upregulation promotes GEM chemoresistance in pancreatic cancer by activating the Wnt signaling pathway	16
Exploring the role of oxidative stress in carotid atherosclerosis: insights from transcriptomic data and single-cell sequencing combined with machine learning	16
p53 regulates expression of nuclear envelope components in cancer cells	16
Loss of the centrosomal protein ALMS1 alters lipid metabolism and the regulation of extracellular matrix-related processes	16
RCC2 promotes prostate cancer cell proliferation and migration through Hh/GLI1 signaling pathway and cancer stem-like cells	16
Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies	15
A multi-omics exploration of PPARG activation in colon cancer: kinases featuring a PPRE sequence within regulatory regions	15
Identification of druggable targets in acute kidney injury by proteome- and transcriptome-wide Mendelian randomization and bioinformatics analysis	15
Correction: Affibodies as valuable tool to prevent β2m aggregation under lysosomal-like conditions	15
FXR1 associates with and degrades PDZK1IP1 and ATOH8 mRNAs and promotes esophageal cancer progression	15
MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis	13
Colon cancer exosome-associated HSP90B1 initiates pre-metastatic niche formation in the liver by polarizing M1 macrophage into M2 phenotype	13
Long-range enhancement of N501Y-endowed mouse infectivity of SARS-CoV-2 by the non-RBD mutations of Ins215KLRS and H655Y	13
Machine learning-driven estimation of mutational burden highlights DNAH5 as a prognostic marker in colorectal cancer	13
RPL35A promotes the progression of cholangiocarcinoma by mediating HSPA8 ubiquitination	13
USP44 regulates HEXIM1 stability to inhibit tumorigenesis and metastasis of oral squamous cell carcinoma	13
Artificial genetic polymers against human pathologies	12
ILC1-derived IFN-γ regulates macrophage activation in colon cancer	12
Integrative genomics unveils basement membrane-related diagnostic markers and therapeutic targets in esophageal squamous cell carcinoma	12
The role of endothelial cell-related gene COL1A1 in prostate cancer diagnosis and immunotherapy: insights from machine learning and single-cell analysis	12
LncRNA MIR205HG accelerates cell proliferation, migration and invasion in hepatoblastoma through the activation of MAPK signaling pathway and PI3K/AKT signaling pathway	12
Eraldo Antonini Lectures, 1983–2019	12
BMC Caller: a webtool to identify and analyze bacterial microcompartment types in sequence data	12
In vitro synergistic effect of AXL, FAK and ErbB receptors inhibitors for head and neck cancer	11
Shaping root architecture: towards understanding the mechanisms involved in lateral root development	11
Dysregulation and antimetastatic function of circLRIG1 modulated by miR-214-3p/LRIG1 axis in bladder carcinoma	11
Tissue-specific roles of peroxisomes revealed by expression meta-analysis	11
Single-cell transcriptomic profiling unveils insights into ovarian fibrosis in obese mice	11
Lactobacillus rhamnosus GG ameliorates radiation-induced lung fibrosis via lncRNASNHG17/PTBP1/NICD axis modulation	11
Mir-338-3p targeting THBS1 attenuates glioma progression by inhibiting the PI3K/Akt pathway	10
Alpha-actnin-4 (ACTN4) selectively affects the DNA double-strand breaks repair in non-small lung carcinoma cells	10
Dual-labeled nanoparticles based on small extracellular vesicles for tumor detection	10
Differential adaptive RNA editing signals between insects and plants revealed by a new measurement termed haplotype diversity	10
Biological roles of RNA m7G modification and its implications in cancer	10
A link between mitotic defects and mitotic catastrophe: detection and cell fate	10
Autophagy inhibition potentiates anti-cancer activity of Sunitinib in kidney cancer cells	10
Understanding p53 tumour suppressor network	10
HOXB4/METTL7B cascade mediates malignant phenotypes of hepatocellular carcinoma through TKT m6A modification	10
Ti3C2 (MXene) nanosheets disrupt spermatogenesis in male mice mediated by the ATM/p53 signaling pathway	10
SPI1 upregulated LILRB2 to enhance the immunosuppressive phenotype of LPS-tolerant macrophages by inhibiting TLR8-mediated MyD88/NF-κB signaling	10

miPEP31 alleviates sepsis development by regulating Chi3l1-dependent macrophage polarization	10
Image-based modeling of vascular organization to evaluate anti-angiogenic therapy	10
The oncogenic role and regulatory mechanism of PGK1 in human non-small cell lung cancer	9
Estrogen receptor alpha dynamics and plasticity during endocrine resistance	9
Probing pathways by which rhynchophylline modifies sleep using spatial transcriptomics	9
Sorafenib-induced macrophage extracellular traps via ARHGDIG/IL4/PADI4 axis confer drug resistance through inhibiting ferroptosis in hepatocellular carcinoma	9
RARRES1 inhibits hepatocellular carcinoma progression and increases its sensitivity to lenvatinib through interaction with SPINK2	8
Reprogramming hematopoietic stem cell metabolism in lung cancer: glycolysis, oxidative phosphorylation, and the role of 2-DG	8
Transcription factor KLF15 inhibits the proliferation and migration of gastric cancer cells via regulating the TFAP2A-AS1/NISCH axis	8
miR-155 mediated regulation of PKG1 and its implications on cell invasion, migration, and apoptosis in preeclampsia through NF-κB pathway	8
Mir-421 and mir-550a-1 are potential prognostic markers in esophageal adenocarcinoma	8
Targeting SOX4/PCK2 signaling suppresses neuroendocrine trans-differentiation of castration-resistant prostate cancer	8
The role of LINC01419 in regulating the cell stemness in lung adenocarcinoma through recruiting EZH2 and regulating FBP1 expression	8
Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblasts	8
A functional approach to homeostatic regulation	8
Integrating machine learning models with multi-omics analysis to decipher the prognostic significance of mitotic catastrophe heterogeneity in bladder cancer	8
Correction: Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblasts	7
Host-mediated RNA editing in viruses	7
Construction of a prognostic model based on disulfidptosis-related genes and identification of CCNA2 as a novel biomarker for hepatocellular carcinoma	7
Comprehensive pan-cancer analysis indicates UCHL5 as a novel cancer biomarker and promotes cervical cancer progression through the Wnt signaling pathway	7
Single-cell RNA sequencing reveals a new mechanism of endothelial cell heterogeneity and healing in diabetic foot ulcers	7
Correction: IPSC derived cardiac fibroblasts of DMD patients show compromised actin microfilaments, metabolic shift and pro-fibrotic phenotype	7
LncRNA5251 inhibits spermatogenesis via modification of cell-cell junctions	7
Quinolinic acid impairs mitophagy promoting microglia senescence and poor healthspan in C. elegans: a mechanism of impaired aging process	7
Circular RNA hsa_circ_0067842 facilitates tumor metastasis and immune escape in breast cancer through HuR/CMTM6/PD-L1 axis	7
m6A methylation-mediated lncRNA RNF144A-AS1 promotes hepatocellular carcinoma progression through the miR-1301-3p/RNF38 pathway	7
In silico optimization of RNA–protein interactions for CRISPR-Cas13-based antimicrobials	7
Glucose deprivation-induced disulfidptosis in human nucleus pulposus cells: a novel pathological mechanism of intervertebral disc degeneration	7
Identification of M2 macrophage-related genes associated with diffuse large B-cell lymphoma via bioinformatics and machine learning approaches	7
Upregulation of long intergenic non-coding RNA LINC00326 inhibits non-small cell lung carcinoma progression by blocking Wnt/β-catenin pathway through modulating the miR-657/dickkopf WNT signaling path	7
cGAS-STING targeting offers therapy choice in lung diseases	7
ADSC-derived exosomes attenuate myocardial infarction injury by promoting miR-205-mediated cardiac angiogenesis	7
Loss of AMPK activity induces organelle dysfunction and oxidative stress during oocyte aging	6
Did the early full genome sequencing of yeast boost gene function discovery?	6
Proteomics and digital subtraction angiography approaches reveal CDH18 as a potential target for therapy of moyamoya disease	6
METTL3 in cancer-associated fibroblasts-derived exosomes promotes the proliferation and metastasis and suppresses ferroptosis in colorectal cancer by eliciting ACSL3 m6A modification	6
Ultrastructural studies distinguish skin diversities among Galápagos iguanas	6
Affibodies as valuable tool to prevent β2m aggregation under lysosomal-like conditions	6
Fraxinellone-mediated targeting of cathepsin B leakage from lysosomes induces ferroptosis in fibroblasts to inhibit hypertrophic scar formation	6
Unraveling the oxidative stress landscape in diabetic foot ulcers: insights from bulk RNA and single-cell RNA sequencing data	6
Single-cell transcriptomics reveals cellular heterogeneity and macrophage-to-mesenchymal transition in bicuspid calcific aortic valve disease	6
PNSC928, a plant-derived compound, specifically disrupts CtBP2-p300 interaction and reduces inflammation in mice with acute respiratory distress syndrome	6
METTL3-induced lncRNA GBAP1 promotes hepatocellular carcinoma progression by activating BMP/SMAD pathway	6
Deep learning-assisted high-content screening identifies isoliquiritigenin as an inhibitor of DNA double-strand breaks for preventing doxorubicin-induced cardiotoxicity	6
Unveiling the molecular profile of a prostate carcinoma: implications for personalized medicine	6
Redressing the interactions between stem cells and immune system in tissue regeneration	6
Prognostic model integrating histology, systemic inflammation, and recurrence status predicts immunotherapy response in advanced non-small-cell lung cancer patients	6
Spinal apolipoprotein E is involved in inflammatory pain via regulating lipid metabolism and glial activation in the spinal dorsal horn	6
The CXCR3/PLC/IP3-IP3R axis is responsible for the ignition of UPR in intestinal epithelial cells exposed to gliadin peptide, during the onset of celiac disease	6
Integrating Circle-Seq with transcriptomics reveals genome-wide characterization of extrachromosomal circular DNA for dilated cardiomyopathy	6
Elevated SREBP1 accelerates the initiation and growth of pancreatic cancer by targeting SOX9	6
AQP5 trafficking is regulated by its C-terminal tail and interaction with prolactin-inducible protein	6
Genomic characteristics and evolution of Multicentric Esophageal and gastric Cardiac Cancer	6
Identification of fatty acid metabolism-related lncRNAs in the prognosis and immune microenvironment of colon adenocarcinoma	6
Autophagy is influenced by vitamin D3 level in people with HIV-1	5
Long-read assembly of major histocompatibility complex and killer cell immunoglobulin-like receptor genome regions in cynomolgus macaque	5
scE2EGAE: enhancing single-cell RNA-Seq data analysis through an end-to-end cell-graph-learnable graph autoencoder with differentiable edge sampling	5
p53-driven lipidome influences non-cell-autonomous lysophospholipids in pancreatic cancer	5
Identification of novel snoRNA-based biomarkers for clear cell renal cell carcinoma from urine-derived extracellular vesicles	5
NUAK2 and RCan2 participate in the p53 mutant pro-tumorigenic network	5
Sigma-1 receptor activation attenuates DOX-induced cardiotoxicity by alleviating endoplasmic reticulum stress and mitochondrial calcium overload via PERK and IP3R-VDAC1-MCU signaling pathways	5
GPR137 inactivates Hippo signaling to promote gastric cancer cell malignancy	5
m6A-mediated upregulation of LINC01003 regulates cell migration by targeting the CAV1/FAK signaling pathway in glioma	5
Integrating multi-layered biological priors to improve genomic prediction accuracy in beef cattle	5
LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis	5
Lifestyle-dependent microglial plasticity: training the brain guardians	5
Long non-coding RNA SNHG8 enhances triple-negative breast cancer cell proliferation and migration by regulating the miR-335-5p/PYGO2 axis	5
PLAU promotes growth and attenuates cisplatin chemosensitivity in ARID1A-depleted non-small cell lung cancer through interaction with TM4SF1	5
Dynamic expression of IGFBP3 modulate dual actions of mineralization micro-environment during tooth development via Wnt/beta-catenin signaling pathway	5
Identifying the driver miRNAs with somatic copy number alterations driving dysregulated ceRNA networks in cancers	5
Analysis of lineage-specific protein family variability in prokaryotes combined with evolutionary reconstructions	5
Rab32 uses its effector reticulon 3L to trigger autophagic degradation of mitochondria-associated membrane (MAM) proteins	5
Antitumoral effects of Bortezomib in malignant mesothelioma: evidence of mild endoplasmic reticulum stress in vitro and activation of T cell response in vivo	5
Phosphodiesterase type 5 inhibitor tadalafil reduces prostatic fibrosis via MiR-3126-3p/FGF9 axis in benign prostatic hyperplasia	5
Exploring the association between osteoporosis and kidney stones: a clinical to mechanistic translational study based on big data and bioinformatics	5
TIMM8B promotes oxidative phosphorylation and glycolysis by inhibiting the mtROS/ASK1/JNK signaling pathway in ovarian cancer	5
Lysine-specific methyltransferase Set7/9 in stemness, differentiation, and development	5
A glutamine metabolish-associated prognostic model to predict prognosis and therapeutic responses of hepatocellular carcinoma	5
Mammalian enabled protein enhances tamoxifen sensitivity of the hormone receptor-positive breast cancer patients by suppressing the AKT signaling pathway	5
miR-210 is essential to retinal homeostasis in fruit flies and mice	4

BRD4 sustains p63 transcriptional program in keratinocytes	4
Valentina Tassinari, the legacy of a young scientist	4
Vemurafenib induces senescence in acute myeloid leukemia and myelodysplastic syndrome by activating the HIPPO signaling pathway: implications for potential targeted therapy	4
Coordinating energy metabolism and signaling pathways in epithelial self-renewal and differentiation	4
Hypoxia-induced activation of HIF-1alpha/IL-1beta axis in microglia promotes glioma progression via NF-κB-mediated upregulation of heparanase expression	4
Are prime numbers special? Insights from the life sciences	4
Utilizing liquid-liquid biopolymer regulators to predict the prognosis and drug sensitivity of hepatocellular carcinoma	4
Functional genomic imaging (FGI), a virtual tool for visualization of functional gene expression modules in heterogeneous tumor samples	4
Depletion of LONP2 unmasks differential requirements for peroxisomal function between cell types and in cholesterol metabolism	4
Deubiquitination of DNM1L by USP3 triggers the development and metastasis of gallbladder carcinoma	4
Regulating ferroptosis by non-coding RNAs in hepatocellular carcinoma	4
Integrated machine learning reveals the role of tryptophan metabolism in clear cell renal cell carcinoma and its association with patient prognosis	4
Early-stage administration of hydroxytyrosol extends lifespan and delays aging in C. elegans	4
Prognostic model of lung adenocarcinoma based on disulfidptosis-related genes and analysis of in vitro cell experiments for PPP1R14B in the model	4
MIR194-2HG, a miRNA host gene activated by HNF4A, inhibits gastric cancer by regulating microRNA biogenesis	4
ACSM5 inhibits ligamentum flavum hypertrophy by regulating lipid accumulation mediated by FABP4/PPAR signaling pathway	4
Efficient DNA-free co-targeting of nuclear genes in Chlamydomonas reinhardtii	4
CircRNA_15430 reduced by Helicobacter pylori infection and suppressed gastric cancer progression via miR-382-5p/ZCCHC14 axis	4
Extracellular vesicles derived from different tissues attenuate cardiac dysfunction in murine MI models	4
Machine learning model reveals the role of angiogenesis and EMT genes in glioma patient prognosis and immunotherapy	4
Transcriptional diversity in specific synaptic gene sets discriminates cortical neuronal identity	3
Identification of metastasis-related genes for predicting prostate cancer diagnosis, metastasis and immunotherapy drug candidates using machine learning approaches	3
HIV-1LAI Nef blocks the development of hematopoietic stem/progenitor cells into myeloid-erythroid lineage cells	3
Active enhancers: recent research advances and insights into disease	3
ZNF692 promotes osteosarcoma cell proliferation, migration, and invasion through TNK2-mediated activation of the MEK/ERK pathway	3
E3 ligase HERC5-catalyzed UGDH isgylation promotes SNAI1-mediated tumor metastasis and cisplatin resistance in oral squamous cell carcinoma	3
Total network controllability analysis discovers explainable drugs for Covid-19 treatment	3
Correction: ILC1-derived IFN-γ regulates macrophage activation in colon cancer	3
Acetylation- and ubiquitination-regulated SFMBT2 acts as a tumor suppressor in clear cell renal cell carcinoma	3
Disulfidptosis signature predicts immune microenvironment and prognosis of gastric cancer	3
Breaking barriers: improving time and space resolution of arbuscular mycorrhizal symbiosis with single-cell sequencing approaches	3
Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer	3
LINC00885 promotes cervical cancer progression through sponging miR-3150b-3p and upregulating BAZ2A	3
GALNT9 enrichment attenuates MPP+-induced cytotoxicity by ameliorating protein aggregations containing α-synuclein and mitochondrial dysfunction	3
Overexpression of ZNF488 supports pancreatic cancer cell proliferation and tumorigenesis through inhibition of ferroptosis via regulating SCD1-mediated unsaturated fatty acid metabolism	3
Combined treatment of nerve growth factor and transcranical direct current stimulations to improve outcome in children with vegetative state after out-of-hospital cardiac arrest	3
Plasma N-Glycoproteomics in monozygotic twin pairs discordant for body mass index reveals an obesity signature related to inflammation and iron metabolism	3
Ubiquitin recruiting chimera: more than just a PROTAC	3
OTUD5 promotes the growth of hepatocellular carcinoma by deubiquitinating and stabilizing SLC38A1	3
USP40 promotes hepatocellular carcinoma cell proliferation, migration and stemness by deubiquitinating and stabilizing Claudin1	3