OOIR: Observatory of International Research

Papers

(The TQCC of Biology Direct is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
USP5 knockdown alleviates lung cancer progression via activating PARP1-mediated mTOR signaling pathway	91
Long-term longitudinal study on swine VML model	71
DEPTOR attenuates asthma progression by suppressing endoplasmic reticulum stress through SOD1	56
MINPP1 promotes ferroptosis in HBV-related hepatocellular carcinoma by regulating CTSB K33-linked deubiquitination via ZRANB1	56
Exploring the role of GhN/AINV23: implications for plant growth, development, and drought tolerance	46
Circ_0002669 promotes osteosarcoma tumorigenesis through directly binding to MYCBP and sponging miR-889-3p	43
Moving biology direct towards a new dimension	41
Wandering about allostery	39
Single-cell RNA sequencing reveals the critical role of alternative splicing in cattle testicular spermatagonia	38
Equol exerts anti-tumor effects on choriocarcinoma cells by promoting TRIM21-mediated ubiquitination of ANXA2	37
NID1 promotes laryngeal cancer stemness via activating WNT pathway	33
Prostatitis, benign prostatic hyperplasia, and prostate cancer: a bidirectional Mendelian randomization study and clinical implications for these patients’ populations	32
Functional and structural characterization of the human indolethylamine N-methyltransferase through fluorometric, thermal and computational docking analyses	31
Molecular mechanisms of efferocytosis imbalance in the idiopathic pulmonary fibrosis microenvironment: from gene screening to dynamic regulation analysis	31
RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment	29
Identification of a prognostic cuproptosis-related signature in hepatocellular carcinoma	28
Neuregulin-4 protects cardiomyocytes against high-glucose-induced ferroptosis via the AMPK/NRF2 signalling pathway	28
Deciphering the role of SAMHD1 in endometrial cancer progression	27
Epigenetic mechanism of RBM15 in affecting cisplatin resistance in laryngeal carcinoma cells by regulating ferroptosis	24
Dualistic role of ZEB1 and ZEB2 in tumor progression	24
Biochemical characterization of the feedforward loop between CDK1 and FOXM1 in epidermal stem cells	23
DTX2 promotes glioma development via regulation of HLTF	23
ARMCX1 inhibits lung adenocarcinoma progression by recruiting FBXW7 for c-Myc degradation	22
Lactobacillus reuteri mitigates hepatic ischemia/reperfusion injury by modulating gut microbiota and metabolism through the Nrf2/HO-1 signaling	21
An exploration into the diagnostic capabilities of microRNAs for myocardial infarction using machine learning	21

The deubiquitinating protein OTUD6B promotes lung adenocarcinoma progression by stabilizing RIPK1	20
Circulating extracellular vesicles regulate ELAVL1 by delivering miR-133a-3p which affecting NLRP3 mRNA stability inhibiting PANoptosome formation	20
ZNF330/NOA36 interacts with HSPA1 and HSPA8 and modulates cell cycle and proliferation in response to heat shock in HEK293 cells	20
Conventional type 1 dendritic cells (cDC1) in cancer immunity	19
The p53 family member p73 in the regulation of cell stress response	19
M2 macrophage-derived exosomal miR-193b-3p promotes progression and glutamine uptake of pancreatic cancer by targeting TRIM62	18
Martin Karplus (1930–2024)	18
The role of SH3RF2 in lung squamous cell carcinoma and M2 polarization: insights into LZTS2 ubiquitination	18
Lipidome atlas of p53 mutant variants in pancreatic cancer	17
A multi-omics exploration of PPARG activation in colon cancer: kinases featuring a PPRE sequence within regulatory regions	17
p53 regulates expression of nuclear envelope components in cancer cells	16
MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis	16
Loss of the centrosomal protein ALMS1 alters lipid metabolism and the regulation of extracellular matrix-related processes	16
Correction: Affibodies as valuable tool to prevent β2m aggregation under lysosomal-like conditions	16
The RRP9-JUN axis promotes breast cancer progression via the AKT signalling pathway	16
Identification of druggable targets in acute kidney injury by proteome- and transcriptome-wide Mendelian randomization and bioinformatics analysis	15
Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies	15
Exploring the role of oxidative stress in carotid atherosclerosis: insights from transcriptomic data and single-cell sequencing combined with machine learning	15
Exploring the molecular mechanism of estrogen therapy effectiveness after TCRA in IUA patients at single-cell level	15
N6-methyladenosine-mediated SH3BP5-AS1 upregulation promotes GEM chemoresistance in pancreatic cancer by activating the Wnt signaling pathway	14
FXR1 associates with and degrades PDZK1IP1 and ATOH8 mRNAs and promotes esophageal cancer progression	14
RCC2 promotes prostate cancer cell proliferation and migration through Hh/GLI1 signaling pathway and cancer stem-like cells	13
Machine learning-driven estimation of mutational burden highlights DNAH5 as a prognostic marker in colorectal cancer	13
USP44 regulates HEXIM1 stability to inhibit tumorigenesis and metastasis of oral squamous cell carcinoma	13
LncRNA MIR205HG accelerates cell proliferation, migration and invasion in hepatoblastoma through the activation of MAPK signaling pathway and PI3K/AKT signaling pathway	13
Correction: High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinoma	13
Colon cancer exosome-associated HSP90B1 initiates pre-metastatic niche formation in the liver by polarizing M1 macrophage into M2 phenotype	13
Long-range enhancement of N501Y-endowed mouse infectivity of SARS-CoV-2 by the non-RBD mutations of Ins215KLRS and H655Y	13
Indispensable role of AcrEF in modulating Salmonella virulence and disrupting host tight junctions to facilitate paracellular entry and invasion	12
The role of endothelial cell-related gene COL1A1 in prostate cancer diagnosis and immunotherapy: insights from machine learning and single-cell analysis	12
ILC1-derived IFN-γ regulates macrophage activation in colon cancer	12
Dysregulation and antimetastatic function of circLRIG1 modulated by miR-214-3p/LRIG1 axis in bladder carcinoma	12
Eraldo Antonini Lectures, 1983–2019	12
RPL35A promotes the progression of cholangiocarcinoma by mediating HSPA8 ubiquitination	12
Artificial genetic polymers against human pathologies	12
In vitro synergistic effect of AXL, FAK and ErbB receptors inhibitors for head and neck cancer	12
BMC Caller: a webtool to identify and analyze bacterial microcompartment types in sequence data	12
A link between mitotic defects and mitotic catastrophe: detection and cell fate	12
Autophagy inhibition potentiates anti-cancer activity of Sunitinib in kidney cancer cells	11
Tissue-specific roles of peroxisomes revealed by expression meta-analysis	11
Integrative genomics unveils basement membrane-related diagnostic markers and therapeutic targets in esophageal squamous cell carcinoma	11
Single-cell transcriptomic profiling unveils insights into ovarian fibrosis in obese mice	11
Shaping root architecture: towards understanding the mechanisms involved in lateral root development	11
Lactobacillus rhamnosus GG ameliorates radiation-induced lung fibrosis via lncRNASNHG17/PTBP1/NICD axis modulation	11
Mir-338-3p targeting THBS1 attenuates glioma progression by inhibiting the PI3K/Akt pathway	11
Ti3C2 (MXene) nanosheets disrupt spermatogenesis in male mice mediated by the ATM/p53 signaling pathway	10
Alpha-actnin-4 (ACTN4) selectively affects the DNA double-strand breaks repair in non-small lung carcinoma cells	10
Image-based modeling of vascular organization to evaluate anti-angiogenic therapy	10
miPEP31 alleviates sepsis development by regulating Chi3l1-dependent macrophage polarization	10
Dual-labeled nanoparticles based on small extracellular vesicles for tumor detection	10

HOXB4/METTL7B cascade mediates malignant phenotypes of hepatocellular carcinoma through TKT m6A modification	10
Differential adaptive RNA editing signals between insects and plants revealed by a new measurement termed haplotype diversity	10
SPI1 upregulated LILRB2 to enhance the immunosuppressive phenotype of LPS-tolerant macrophages by inhibiting TLR8-mediated MyD88/NF-κB signaling	10
Biological roles of RNA m7G modification and its implications in cancer	10
Mir-421 and mir-550a-1 are potential prognostic markers in esophageal adenocarcinoma	10
The oncogenic role and regulatory mechanism of PGK1 in human non-small cell lung cancer	9
Probing pathways by which rhynchophylline modifies sleep using spatial transcriptomics	9
Reprogramming hematopoietic stem cell metabolism in lung cancer: glycolysis, oxidative phosphorylation, and the role of 2-DG	9
A functional approach to homeostatic regulation	9
Sorafenib-induced macrophage extracellular traps via ARHGDIG/IL4/PADI4 axis confer drug resistance through inhibiting ferroptosis in hepatocellular carcinoma	9
Estrogen receptor alpha dynamics and plasticity during endocrine resistance	9
Necroptosis-driven T cell activation promotes IL-6-mediated PD-L1 upregulation in cholangiocarcinoma cells: IL-6 gene signature as a biomarker for chemo-immunotherapy response	9
RARRES1 inhibits hepatocellular carcinoma progression and increases its sensitivity to lenvatinib through interaction with SPINK2	9
Inhibition of PRC1 elicits immunogenic cell death by triggering ROS-dependent ER stress in colorectal cancer via the Wnt/β-catenin signaling pathway	9
Evolution of cell therapies derived from adipose tissue: historical perspectives, current development trends and future directions	9
Targeting SOX4/PCK2 signaling suppresses neuroendocrine trans-differentiation of castration-resistant prostate cancer	9
Upregulation of long intergenic non-coding RNA LINC00326 inhibits non-small cell lung carcinoma progression by blocking Wnt/β-catenin pathway through modulating the miR-657/dickkopf WNT signaling path	8
Correction: IPSC derived cardiac fibroblasts of DMD patients show compromised actin microfilaments, metabolic shift and pro-fibrotic phenotype	8
Transcription factor KLF15 inhibits the proliferation and migration of gastric cancer cells via regulating the TFAP2A-AS1/NISCH axis	8
Glucose deprivation-induced disulfidptosis in human nucleus pulposus cells: a novel pathological mechanism of intervertebral disc degeneration	8
Correction: Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblasts	8
m6A methylation-mediated lncRNA RNF144A-AS1 promotes hepatocellular carcinoma progression through the miR-1301-3p/RNF38 pathway	8
Spleen granulopoiesis in psoriasis immune microenvironment aggravates psoriasis via IL-6/P-STAT3 signaling	8
miR-155 mediated regulation of PKG1 and its implications on cell invasion, migration, and apoptosis in preeclampsia through NF-κB pathway	8
The role of LINC01419 in regulating the cell stemness in lung adenocarcinoma through recruiting EZH2 and regulating FBP1 expression	8
LncRNA5251 inhibits spermatogenesis via modification of cell-cell junctions	8
In silico optimization of RNA–protein interactions for CRISPR-Cas13-based antimicrobials	8
Identification of M2 macrophage-related genes associated with diffuse large B-cell lymphoma via bioinformatics and machine learning approaches	8
HMGA1 promotes the progression of lung adenocarcinoma through the STAT1-mediated transcriptional activation of DDAH1	8
Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblasts	8
Integrating machine learning models with multi-omics analysis to decipher the prognostic significance of mitotic catastrophe heterogeneity in bladder cancer	8
cGAS-STING targeting offers therapy choice in lung diseases	8