OOIR: Observatory of International Research

Papers

(The TQCC of Biology Direct is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
DEPTOR attenuates asthma progression by suppressing endoplasmic reticulum stress through SOD1	74
Long-term longitudinal study on swine VML model	53
Circ_0002669 promotes osteosarcoma tumorigenesis through directly binding to MYCBP and sponging miR-889-3p	53
Exploring the role of GhN/AINV23: implications for plant growth, development, and drought tolerance	45
USP5 knockdown alleviates lung cancer progression via activating PARP1-mediated mTOR signaling pathway	41
Moving biology direct towards a new dimension	37
Functional and structural characterization of the human indolethylamine N-methyltransferase through fluorometric, thermal and computational docking analyses	35
Prostatitis, benign prostatic hyperplasia, and prostate cancer: a bidirectional Mendelian randomization study and clinical implications for these patients’ populations	35
Single-cell RNA sequencing reveals the critical role of alternative splicing in cattle testicular spermatagonia	35
Wandering about allostery	34
NID1 promotes laryngeal cancer stemness via activating WNT pathway	30
Neuregulin-4 protects cardiomyocytes against high-glucose-induced ferroptosis via the AMPK/NRF2 signalling pathway	29
Equol exerts anti-tumor effects on choriocarcinoma cells by promoting TRIM21-mediated ubiquitination of ANXA2	29
Deciphering the role of SAMHD1 in endometrial cancer progression	29
RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment	28
Epigenetic mechanism of RBM15 in affecting cisplatin resistance in laryngeal carcinoma cells by regulating ferroptosis	28
Identification of a prognostic cuproptosis-related signature in hepatocellular carcinoma	26
Dualistic role of ZEB1 and ZEB2 in tumor progression	26
The deubiquitinating protein OTUD6B promotes lung adenocarcinoma progression by stabilizing RIPK1	25
Circulating extracellular vesicles regulate ELAVL1 by delivering miR-133a-3p which affecting NLRP3 mRNA stability inhibiting PANoptosome formation	24
The p53 family member p73 in the regulation of cell stress response	24
ARMCX1 inhibits lung adenocarcinoma progression by recruiting FBXW7 for c-Myc degradation	23
DTX2 promotes glioma development via regulation of HLTF	22
ZNF330/NOA36 interacts with HSPA1 and HSPA8 and modulates cell cycle and proliferation in response to heat shock in HEK293 cells	21
An exploration into the diagnostic capabilities of microRNAs for myocardial infarction using machine learning	20

Biochemical characterization of the feedforward loop between CDK1 and FOXM1 in epidermal stem cells	19
Lactobacillus reuteri mitigates hepatic ischemia/reperfusion injury by modulating gut microbiota and metabolism through the Nrf2/HO-1 signaling	18
Exploring the molecular mechanism of estrogen therapy effectiveness after TCRA in IUA patients at single-cell level	18
M2 macrophage-derived exosomal miR-193b-3p promotes progression and glutamine uptake of pancreatic cancer by targeting TRIM62	18
Conventional type 1 dendritic cells (cDC1) in cancer immunity	18
Martin Karplus (1930–2024)	16
Correction: High-fat diet impairs ferroptosis and promotes cancer invasiveness via downregulating tumor suppressor ACSL4 in lung adenocarcinoma	16
Exploring the role of oxidative stress in carotid atherosclerosis: insights from transcriptomic data and single-cell sequencing combined with machine learning	16
Lipidome atlas of p53 mutant variants in pancreatic cancer	15
Identification of druggable targets in acute kidney injury by proteome- and transcriptome-wide Mendelian randomization and bioinformatics analysis	15
MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis	15
The RRP9-JUN axis promotes breast cancer progression via the AKT signalling pathway	15
Loss of the centrosomal protein ALMS1 alters lipid metabolism and the regulation of extracellular matrix-related processes	14
p53 regulates expression of nuclear envelope components in cancer cells	13
FXR1 associates with and degrades PDZK1IP1 and ATOH8 mRNAs and promotes esophageal cancer progression	13
Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies	13
RCC2 promotes prostate cancer cell proliferation and migration through Hh/GLI1 signaling pathway and cancer stem-like cells	12
BMC Caller: a webtool to identify and analyze bacterial microcompartment types in sequence data	12
Long-range enhancement of N501Y-endowed mouse infectivity of SARS-CoV-2 by the non-RBD mutations of Ins215KLRS and H655Y	12
The role of endothelial cell-related gene COL1A1 in prostate cancer diagnosis and immunotherapy: insights from machine learning and single-cell analysis	12
Colon cancer exosome-associated HSP90B1 initiates pre-metastatic niche formation in the liver by polarizing M1 macrophage into M2 phenotype	12
N6-methyladenosine-mediated SH3BP5-AS1 upregulation promotes GEM chemoresistance in pancreatic cancer by activating the Wnt signaling pathway	12
RPL35A promotes the progression of cholangiocarcinoma by mediating HSPA8 ubiquitination	12
LncRNA MIR205HG accelerates cell proliferation, migration and invasion in hepatoblastoma through the activation of MAPK signaling pathway and PI3K/AKT signaling pathway	11
Machine learning-driven estimation of mutational burden highlights DNAH5 as a prognostic marker in colorectal cancer	11
Artificial genetic polymers against human pathologies	11
ILC1-derived IFN-γ regulates macrophage activation in colon cancer	11
Eraldo Antonini Lectures, 1983–2019	11
USP44 regulates HEXIM1 stability to inhibit tumorigenesis and metastasis of oral squamous cell carcinoma	11
Lactobacillus rhamnosus GG ameliorates radiation-induced lung fibrosis via lncRNASNHG17/PTBP1/NICD axis modulation	11
Alpha-actnin-4 (ACTN4) selectively affects the DNA double-strand breaks repair in non-small lung carcinoma cells	10
Single-cell transcriptomic profiling unveils insights into ovarian fibrosis in obese mice	10
Tissue-specific roles of peroxisomes revealed by expression meta-analysis	10
Ti3C2 (MXene) nanosheets disrupt spermatogenesis in male mice mediated by the ATM/p53 signaling pathway	10
Shaping root architecture: towards understanding the mechanisms involved in lateral root development	10
Integrative genomics unveils basement membrane-related diagnostic markers and therapeutic targets in esophageal squamous cell carcinoma	10
A link between mitotic defects and mitotic catastrophe: detection and cell fate	10
Dysregulation and antimetastatic function of circLRIG1 modulated by miR-214-3p/LRIG1 axis in bladder carcinoma	10
miPEP31 alleviates sepsis development by regulating Chi3l1-dependent macrophage polarization	9
HOXB4/METTL7B cascade mediates malignant phenotypes of hepatocellular carcinoma through TKT m6A modification	9
Differential adaptive RNA editing signals between insects and plants revealed by a new measurement termed haplotype diversity	9
Biological roles of RNA m7G modification and its implications in cancer	9
Understanding p53 tumour suppressor network	9
Mir-338-3p targeting THBS1 attenuates glioma progression by inhibiting the PI3K/Akt pathway	9
Dual-labeled nanoparticles based on small extracellular vesicles for tumor detection	9
A functional approach to homeostatic regulation	8
RARRES1 inhibits hepatocellular carcinoma progression and increases its sensitivity to lenvatinib through interaction with SPINK2	8
Mir-421 and mir-550a-1 are potential prognostic markers in esophageal adenocarcinoma	8
miR-155 mediated regulation of PKG1 and its implications on cell invasion, migration, and apoptosis in preeclampsia through NF-κB pathway	8
The oncogenic role and regulatory mechanism of PGK1 in human non-small cell lung cancer	8

Probing pathways by which rhynchophylline modifies sleep using spatial transcriptomics	8
The role of LINC01419 in regulating the cell stemness in lung adenocarcinoma through recruiting EZH2 and regulating FBP1 expression	8
Sorafenib-induced macrophage extracellular traps via ARHGDIG/IL4/PADI4 axis confer drug resistance through inhibiting ferroptosis in hepatocellular carcinoma	8
Image-based modeling of vascular organization to evaluate anti-angiogenic therapy	8
Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblasts	7
Glucose deprivation-induced disulfidptosis in human nucleus pulposus cells: a novel pathological mechanism of intervertebral disc degeneration	7
Correction: Integrated Mendelian randomization and single-cell RNA-sequencing analyses identified OAS1 as a novel therapeutic target for erectile dysfunction via targeting fibroblasts	7
Reprogramming hematopoietic stem cell metabolism in lung cancer: glycolysis, oxidative phosphorylation, and the role of 2-DG	7
Integrating machine learning models with multi-omics analysis to decipher the prognostic significance of mitotic catastrophe heterogeneity in bladder cancer	7
Targeting SOX4/PCK2 signaling suppresses neuroendocrine trans-differentiation of castration-resistant prostate cancer	7
Transcription factor KLF15 inhibits the proliferation and migration of gastric cancer cells via regulating the TFAP2A-AS1/NISCH axis	7
Construction of a prognostic model based on disulfidptosis-related genes and identification of CCNA2 as a novel biomarker for hepatocellular carcinoma	7
Quinolinic acid impairs mitophagy promoting microglia senescence and poor healthspan in C. elegans: a mechanism of impaired aging process	6
Correction: IPSC derived cardiac fibroblasts of DMD patients show compromised actin microfilaments, metabolic shift and pro-fibrotic phenotype	6
cGAS-STING targeting offers therapy choice in lung diseases	6
In silico optimization of RNA–protein interactions for CRISPR-Cas13-based antimicrobials	6
Spinal apolipoprotein E is involved in inflammatory pain via regulating lipid metabolism and glial activation in the spinal dorsal horn	6
Redressing the interactions between stem cells and immune system in tissue regeneration	6
Comprehensive pan-cancer analysis indicates UCHL5 as a novel cancer biomarker and promotes cervical cancer progression through the Wnt signaling pathway	6
LncRNA5251 inhibits spermatogenesis via modification of cell-cell junctions	6
Circular RNA hsa_circ_0067842 facilitates tumor metastasis and immune escape in breast cancer through HuR/CMTM6/PD-L1 axis	6
Single-cell RNA sequencing reveals a new mechanism of endothelial cell heterogeneity and healing in diabetic foot ulcers	6
Identification of fatty acid metabolism-related lncRNAs in the prognosis and immune microenvironment of colon adenocarcinoma	6
Host-mediated RNA editing in viruses	6
Identification of M2 macrophage-related genes associated with diffuse large B-cell lymphoma via bioinformatics and machine learning approaches	6
ADSC-derived exosomes attenuate myocardial infarction injury by promoting miR-205-mediated cardiac angiogenesis	6
Upregulation of long intergenic non-coding RNA LINC00326 inhibits non-small cell lung carcinoma progression by blocking Wnt/β-catenin pathway through modulating the miR-657/dickkopf WNT signaling path	6
Single-cell transcriptomics reveals cellular heterogeneity and macrophage-to-mesenchymal transition in bicuspid calcific aortic valve disease	6
Loss of AMPK activity induces organelle dysfunction and oxidative stress during oocyte aging	6