OOIR: Observatory of International Research

Papers

(The H4-Index of Expert Opinion on Drug Discovery is 27. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Scaffold hopping approaches for dual-target antitumor drug discovery: opportunities and challenges	166
Lessons learned from phenotypic drug discovery efforts	132
An overview of the preclinical discovery and development of remdesivir for the treatment of coronavirus disease 2019 (COVID-19)	88
The pre-clinical discovery and development of osimertinib used to treat non-small cell lung cancer	81
Advances in the discovery of drugs that treat pulmonary arterial hypertension	77
Strategies for targeting RNA with small molecule drugs	71
Advances in ion channel high throughput screening: where are we in 2023?	70
Polypharmacology prediction: the long road toward comprehensively anticipating small-molecule selectivity to de-risk drug discovery	69
Reality check: lipid-oligonucleotide conjugates for therapeutic applications	59
What is the plausibility that all drugs will be designed by computers by the end of the decade?	56
γ-Secretase: once and future drug target for Alzheimer’s disease	53
Tools and techniques for the discovery of therapeutic aptamers: recent advances	53
Methods in marine natural product drug discovery: what’s new?	50
A comprehensive update on the use of molecular topology applications for anti-infective drug discovery	45
Understanding the impact of binding free energy and kinetics calculations in modern drug discovery	44
An update on knowledge graphs and their current and potential applications in drug discovery	43
C. elegans : a prominent platform for modeling and drug screening in neurological disorders	37
The rules often neglected in current medicinal chemistry	37
A cautionary tale of paradox and false positives in cannabidiol research	37
Acoustic ejection mass spectrometry: fundamentals and applications in high-throughput drug discovery	36
Calcium channel blockers’ contribution to overcoming Current drug discovery challenges in Alzheimer’s disease	35
Water in drug design: pitfalls and good practices	35
Guided structure-based ligand identification and design via artificial intelligence modeling	34
Molecular hybridization: a powerful tool for multitarget drug discovery	30
Virtual screening: hope, hype, and the fine line in between	30

Novel hydrogels: are they poised to transform 3D cell-based assay systems in early drug discovery?	29
Correction	27
Current challenges and future perspectives of drug discovery in China	27
Recent applications of positron emission tomographic (PET) imaging in psychiatric drug discovery	27
Animal models of chronic obstructive pulmonary disease and their role in drug discovery and development: a critical review	27