Chemical Biology & Drug Design

Article	Citations
Cover Image	109
Cover Image	69
Purification and structural analysis of a novel polysaccharide from Rehmannia Radix Praeparata	68
SAR study of small molecule inhibitors of the programmed cell death‐1/programmed cell death‐ligand 1 interaction	61
Estrone analogs as potential inhibitors targeting EGFR‐MAPK pathway in non‐small‐cell lung cancer	57
Folate trapping is lethal to cancer cells	53
Discovery of small molecule c‐Maf inhibitors using molecular docking‐based virtual screening, molecular dynamics simulation, and biological evaluation	51
Two new compounds from endemic Centaurea paphlagonica (Bornm.) Wagenitz and their cytotoxic activities	44
Investigating the Role of Quercetin, an Active Ingredient in Bazhen Decoction, in Targeting CXCL8 to Inhibit Macrophage M2 Polarization and Reshape the Immunological Microenviron	43
Design, synthesis, and evaluation of novel bistrifluoromethyl‐based hydrazones as dual inhibitors of acetylcholinesterase and carbonic anhydrase enzymes for Alzheimer's disease	43
Correction to Silencing PCMT1 enhances the sensitivity of breast cancer cells to paclitaxel through the PI3K/Akt/STMN1 pathway	42
Effect of novel therapeutic medicine swertiamarin from Enicostema axillare in zebrafish infected with Salmonella typhi	41
Arylnitro monocarbonyl curcumin analogues: Synthesis and in vitro antitubercular evaluation	40
Computationally Guided Structural Modification of Centaureidin: A Novel Approach for Enhancing Antioxidant and Antitumor Activities for Drug Development	40
Synthesis and antiviral activity of diverse heterocyclic scaffolds	39
Ginsenoside Rg1 improves Alzheimer's disease by regulating oxidative stress, apoptosis, and neuroinflammation through Wnt/GSK‐3β/β‐catenin signaling pathway	38
Computationally Driven Exploration of Novel bis‐Thiadiazole Sulfonamides as Alzheimer's Enzyme Inhibitors: A DFT and Kinetic Perspective	38
Discussion on structure classification and regulation function of histone deacetylase and their inhibitor	37
Potential Modulatory Effects of Hesperidin on the JAK/STAT Pathway in Mesangial Proliferative Glomerulonephritis	36
A Comprehensive Analysis on Galantamine Based Hybrids for the Management of Alzheimer's Disease	35
Cover Image	33
Issue Information	32
Exploration of potential inhibitors for autophagy‐related protein 8 as antileishmanial agents	32
	31
Preparation and biological evaluation of new antimicrotubule agents: Modification of the imidazolidin‐2‐one moiety of phenyl 4‐(2‐oxoimidazolidin‐1‐yl)benzenesulfonates	30

Orthogonal threading‐through‐β‐sheet design of lung cancer EGFR extracellular domain‐derived peptidic mimotopes binding to anti‐EGFR antibody	30
Elucidating the cellular uptake mechanisms of heptamethine cyanine dye analogues for their use as an anticancer drug‐carrier molecule for the treatment of glioblastoma	30
	30
A recent update on huprine and its hybrids as a potential multifunctional agent for the treatment of Alzheimer's disease	29
Design, synthesis and characterization of ethyl 3‐benzoyl‐7‐morpholinoindolizine‐1‐carboxylate as anti‐tubercular agents: In silico screening for possible target identification	28
Synthesis and evaluation of di‐heterocyclic benzazole compounds as potential antibacterial and anti‐biofilm agents against Staphylococcus aureus	28
C2‐linked alkynyl poly‐ethylene glycol(PEG) adenosine conjugates as water‐soluble adenosine receptor agonists	25
	25
Corrigendum	25
Tetrazole: A privileged scaffold for the discovery of anticancer agents	25
Hybrid PABA‐glutamic acid conjugated 1,3,5‐triazine derivatives: Design, synthesis, and antimalarial activity screening targeting Plasmodium falciparum dihydro folate reductase enzym	25
miRNAs as key modulators between normal cells and tumor microenvironment interactions	25
Why are heterocycles so special in medicinal chemistry?	25
In silico prediction of boiling point, octanol–water partition coefficient, and retention time index of polycyclic aromatic hydrocarbons through machine learning	24
The Molecular Mechanism of Resveratrol in the Treatment of Chronic Rhinosinusitis Through a Combination of Network Pharmacology and In Vitro Validation	23
TMEM97 knockdown inhibits 5‐fluorouracil resistance by regulating epithelial‐mesenchymal transition and ABC transporter expression via inactivating the Akt/mTOR pathwa	22
Paclitaxel may inhibit migration and invasion of gastric cancer cells via nod‐like receptor family pyrin domain‐containing 3/caspase‐1/Gasdermin E mediated pyroptosis pathway	22
Novel Phenoxyacetic Acid (4‐Aminophenoacetic Acid) Shikonin Ester Kills KRAS Mutant Colon Cancer Cells via Targeting the Akt Allosteric Site	22
Investigating potential mechanisms of vitamin D against thyroid cancer via network pharmacology and experimental validation	21
Machine Learning‐Based Discovery of a Novel Noncovalent MurA Inhibitor as an Antibacterial Agent	21
Cover Image	21
BSV163/DOPE‐mediated TRAIL gene transfection acts synergistically with chemotherapy against cisplatin‐resistant ovarian cancer	21
A Naturally Derived Glycosylated Oleanolic Acid Derivative Suppresses NF‐κB Translocation and Induces Intrinsic Apoptosis in Lung Adenocarcinoma Cells	21
Network pharmacology analysis and experimental evaluations of YH complex on androgenetic alopecia by regulating the androgenic‐apoptotic axis	20
Chemistry and biological evaluation of pyrido[4,3‐d]pyrimidines: A review	19
Friedlӓnder's synthesis of quinolines as a pivotal step in the development of bioactive heterocyclic derivatives in the current era of medicinal chemistry	19
Methyl benzoate and cinnamate analogs as modulators of DNA methylation in hepatocellular carcinoma	19
Glycyrrhizic acid inhibits DNA damage repair and enhances cisplatin‐induced apoptosis of melanoma cells	19
Praeruptorin A inhibits the activation of NF‐κB pathway and the expressions of inflammatory factors in poly (I:C)‐induced RAW264.7 cells	19
Dietary Natural Flavonoids: Intervention for MAO‐B Against Parkinson's Disease	19
Quercetin Prevents Hyperuricemia Associated With Gouty Arthritis by Inactivating the NLRP3/NF‐κB Signaling Pathway	18
Small Molecule Inhibitors Targeting Cdc2‐Like Kinase 4: Advances, Challenges, and Opportunities	18
δ‐Tocotrienol Potentiates Breast and Prostate Cancer Cells to Paclitaxel via Suppressing PD‐L1‐Mediated Cancer‐Promoting Signaling	18
Predicting clinical trial outcomes using drug bioactivities through graph database integration and machine learning	18
Antitumor and antioxidant activities of polysaccharides from the seaweed Durvillaea antarctica	18
Progress of SARS‐CoV‐2 Main protease peptide‐like inhibitors	18
An appraisal on synthetic and pharmaceutical perspectives of quinoxaline 1,4‐di‐N‐oxide scaffold	17
Issue Information	17
Exploring the interactive mechanism of acarbose with the amylase SusG in the starch utilization system of the human gut symbiont Bacteroides thetaiotaomicron through molecular modeli	17
Sulfonated non‐saccharide molecules and human factor XIa: Enzyme inhibition and computational studies	17
	17
Classification of beta‐site amyloid precursor protein cleaving enzyme 1 inhibitors by using machine learning methods	17
Chemical synthesis, biological activities, and molecular simulations of novel sulfonylurea compounds bearing ortho‐alkoxy substitutions	17
The designation, synthesis, and affinity determination of affinity peptide for anthrax protective antigen	16
Dexmedetomidine attenuates myocardial ischemia–reperfusion injury in hyperlipidemic rats by inhibiting inflammation, oxidative stress and NF‐κB	16
Glabridin inhibits urothelial bladder carcinoma cell growth in vitro and in vivo by inducing cell apoptosis and cell cycle arrest	16
In vitro cytotoxicity and docking study of novel symmetric and asymmetric dihydropyridines and pyridines as EGFR tyrosine kinase inhibitors	16
Synthesis and anti‐tumor activity evaluation of 1H‐pyrrolo[2,3‐b]pyridine‐2‐carboxamide derivatives with phenyl sulfonamide groups as potent RSK2 inhibitors	15
Exploring the Artificial Intelligence and Its Impact in Pharmaceutical Sciences: Insights Toward the Horizons Where Technology Meets Tradition	15
Cover Image	15

Design, synthesis, in vitro evaluation, and molecular modeling studies of N‐substituted benzomorphans, analogs of LP2, as novel MOR ligands	15
In vitro effects of thirty‐eight cardiac drugs on human serum paraoxonase	15
Curcumin activates the JNK signaling pathway to promote ferroptosis in colon cancer cells	15
2, 4, 5‐Trideoxyhexopyranosides derivatives of diphyllin: Synthesis and anticancer activity	15
In vitro and in vivo antileishmanial activity of the hanging sedge flavonoids based on bio‐ guided fractionation assay	14
Lycopersene: A review on extraction, identification and purification and applications	14
Discovery of novel 1,3,5‐triazines as potent antibacterial agent against urinary tract infection‐causing clinical isolates of Escherichia coli via inhibition of DNA Gyrase	14
Synthetic corticotropins and the GABA‐receptor system: Direct and delayed effects	14
Design, synthesis, antibacterial activity evaluation and molecular docking study of pleuromutilin derivatives bearing amide side chains	14
Integrated bioinformatics analysis reveals the bidirectional effects of TSPAN6 for cisplatin resistance in lung cancer	14
Structural and dynamic investigation of non‐synonymous variations in Renin–AGT complex revealed altered binding via hydrogen‐bonding network reprogramming to accelerate the hypertension pathway	14
	14
	14
Issue Information	14
Design and synthesis of five‐membered heterocyclic derivatives of istradefylline with comparable pharmacological activity	13
A comprehensive review on the research progress of PTP1B inhibitors as antidiabetics	13
Baicalein Targets MAPK9 to Induce Apoptosis of Hepatocellular Carcinoma Cells	13
LaSOM335, active against bladder cancer cells, interferes withLet‐60(hRas) and reducesCD73 expression/activity	13
Identification of miR‐3182 and miR‐3143 target genes involved in the cell cycle as a novel approach in TNBC treatment: A systems biology approach	13
Herbacetin Inhibits Human Fructose 1,6‐Bisphosphatase Among a Panel of Chromone Derivatives and Pyrazoles, Demonstrating Positive Effects on Insulin‐Resistant HepG2 Cells	13
Isoxazole and Pyrazole Derivatives of 28‐Oxo‐Allobetulone Target Viral Membrane Glycoprotein Hemagglutinin	13
KH‐17, a simplified derivative of bongkrekic acid, weakly inhibits the mitochondrial ADP/ATP carrier from both sides of the inner mitochondrial membrane	13
Irreversible inhibitors of the proline racemase unveil innovative mechanism of action as antibacterial agents against Clostridioides difficile	13
New class of benzothiophene morpholine analogues with high selectivity and affinity were designed and evaluated for anti‐drug addiction	13
Substrate‐based synthetic strategies and biological activities of 1,3,4‐oxadiazole: A review	13
Anticancer mechanisms of β‐carbolines	12
Targeting Cancer Cell Proliferation Using Piperazine‐Linked Quinolinequinones: Mechanism and Metabolic Profile	12
A Comprehensive Review on the Advancements of Dual COX‐2/5‐LOX Inhibitors as Anti‐Inflammatory Drugs	12
Click chemistry beyond metal‐catalyzed cycloaddition as a remarkable tool for green chemical synthesis of antifungal medications	12
Network pharmacology and in vitro experiments reveal sophoridine‐induced apoptosis and G1 phase arrest via ROS‐dependent PI3K/Akt/FoxO3a pathway	12
Curcumin Regulates Microglia Polarization to Alleviate Ischemic Stroke by Targeting microRNA‐205‐5p/Kruppel‐Like Factor 2 (KLF2)/Activating Transcription Factor 2 (ATF2) Axis	12
Berberine Ameliorates Pulmonary Fibrosis by Inactivating the Thrombospondin 2/Smad Homolog 2/3 Pathway	12
Exploring Thiazole‐Based Heterocycles: Synthesis, Bioactivity, and Molecular Docking for Antimicrobial Applications	11
Issue Information	11
Cover Image	11
Structure‐based discovery of Licoflavone B and Ginkgetin targeting c‐Myc G‐quadruplex to suppress c‐Myc transcription and myeloma growth	11
The medicinal chemistry of piperazines: A review	11
Cover Image	11
Therapeutic efficacy of caffeic acid phenethyl ester in cancer therapy: An updated review	11
Issue Information	11
Synthesis and biological activity profile of novel triazole/quinoline hybrids	10
Design, Synthesis, and Biological Evaluation of New Benzimidazole‐1,2,4‐Triazole Derivatives as Potential Anticancer Agents	10
Kaempferol exerts antioxidant effects in age‐related diminished ovarian reserve by regulating the HSP90/NRF2 pathway	10
EGFR degraders in non‐small‐cell lung cancer: Breakthrough and unresolved issue	10
An insight into cytotoxic activity of flavonoids and sesquiterpenoids from selected plants of Asteraceae species	10
Correction to Plumbagin's Antiproliferative Mechanism in Human Cancer Cells: A Copper‐Dependent Cytotoxic Approach	10
Structure‐Based Design of 2‐Aminopyrazolpyrimidopyridone Derivatives as New Rearranged During Transfection (RET) Kinase Inhibitors	10
Pyrrole‐Tethered Bisbenzoxazole Derivatives: Apoptosis‐Inducing Agents Targeting Breast Cancer Cells	10
Syringic acid suppresses ferroptosis of skeletal muscle cells to alleviate lower limb ischemia/reperfusion injury in mice via the HMGB1 pathway	10
Spalt‐Like Transcription Factor 4 Mediates Fatty Acid Oxidation to Foster 5‐Fluorouracil Resistance in Gastric Cancer Cells	10
β‐elemene enhances cisplatin sensitivity of non‐small cell lung cancer cells via the miR‐17‐5p/STAT3 axis	10
Synthesis of Novel Soritin Sulfonamide Derivatives as Potential α‐Glucosidase Inhibitor and Their Molecular Docking Studies	10
Curcumin inhibits malignant behavior of colorectal cancer cells by regulating M2 polarization of tumor‐associated macrophages and metastasis associated in colon cancer 1 (MACC1)	10
Multi‐fluorine labeled indanone derivatives as potential MRI imaging probes for β‐Amyloid plaques	10
Identification of Potent Leucine‐Rich Repeat Kinase 2 Inhibitors by Virtual Screening and Biological Evaluation	10
Chromones: Privileged scaffold in anticancer drug discovery	9
	9
SU5, a new Auraptene analog with improved metabolic stability, ameliorates nonalcoholic fatty liver disease in methionine‐ and choline‐deficient diet‐fed db/db mice	9
Optimized synthesis, polymer conjugation, and proof‐of‐concept studies of the gd‐IgA1 epitope for antibody‐scavenging therapies in IgA nephropathy	9
Multiple function of lncRNA MALAT1 in cancer occurrence and progression	9
Pyrimidine derivatives as EGFR tyrosine kinase inhibitors in non‐small‐cell lung cancer: A comprehensive review	9
	9
Screening and introduction of key cell cycle microRNAs deregulated in colorectal cancer by integrated bioinformatics analysis	9
The evaluation of isatin analogues as inhibitors of monoamine oxidase	9
Atropisomerism transforming anti‐cancer drug discovery	9
Insights into the structure and drug design of benzimidazole derivatives targeting the epidermal growth factor receptor (EGFR)	9
Local anaesthetic procaine derivatives protect rat against diabetic nephropathy via inhibition of DPP‐4, inflammation and oxidative stress	9
Synthesis and biological evaluation of novel 5,6‐dihydrobenzo[h]quinazoline derivatives as FLT3 inhibitors	9
Exploring Flavonoids as Regulators of MMP‐2 and MMP‐9 in Cancer Pathogenesis	9
Issue Information	9
Current Challenges With Highly Active Antiretroviral Therapy and New Hope and Horizon With CRISPR‐CAS9 Technology for HIV Treatment	9
Synthesis of novel 5‐amido‐2‐carboxypyrazines as inhibitors of the type three secretion system of Salmonella enterica serovar Typhimurium	9
Cover Image	8
NMC‐4 Ameliorates Depression‐Like Behavior and Neuroinflammation Caused by Chronic Unpredictable Mild Stress	8
Therapeutic implications of crocin in Parkinson's disease: A review of preclinical research	8
Exploring the cytotoxic potential of biflavones of Araucaria cunninghamii: Precise identification combined by LC‐HRMS‐metabolomics and database mining, targeted isolation, network pharmacology,	8
Identification of a novel ALDH1A3‐selective inhibitor by a chemical probe with unrelated bioactivity: An approach to affinity‐based drug target discovery	8
Discovery and evaluation of biphenyl derivatives of 2‐iminobenzimidazoles as prototype dual PTP1B inhibitors and AMPK activators with in vivo antidiabetic activity	8
O‐prenylated carbostyrils as a novel class of 15‐lipoxygenase inhibitors: Synthesis, characterization, and inhibitory assessment	8
IGF2BP3 loss inhibits cell progression by upregulating has_circRNA_103820, and hsa_circRNA_103820‐encoded peptide inhibits cell progression by inactivating the AKT pathway in lung cancer	8

Structural Insights Into Papain‐Derived Synthetic Antibacterial Peptides for Targeting Klebsiella pneumoniae	8
Sinigrin improves cerebral ischaemia‐reperfusion injury by inhibiting the TLR4 pathway‐mediated oxidative stress	8
Synthesis and preliminary evaluation of benzylaminoimidazoline derivatives as novel norepinephrine transporter ligands	8
The mannose‐binding protein from Agaricus bisporus inhibits the growth of MDA‐MB‐231 spheroids	8
Design and Synthesized 3,4‐Dimethoxybenzene‐Based Fibrate Derivatives as Potential Hypolipidemic and Liver Protection Agents	8
Elucidation of the mechanisms and molecular targets of KeChuanLiuWei‐Mixture for treatment of severe asthma based on network pharmacology	8
Heterocyclic and non‐heterocyclic arena of monocarboxylate transporter inhibitors to battle tumorigenesis	8
Chromone Derivatives as a Novel NOX4 Inhibitor: Design, Synthesis, and Regulation of ROS in Renal Fibroblast	8
Combination of fenchone and sodium hyaluronate ameliorated constipation‐predominant irritable bowel syndrome and underlying mechanisms	8
Identification of tripeptides against tyrosine kinase domain of EGFR for lung cancer cell inhibition by in silico and in vitro studies	8
Plumbagin induces apoptosis, cell cycle arrest, and inhibits protein synthesis in LoVo colon cancer cells: A proteomic analysis	8
Apelin‐13's Actions in Controlling Hypertension‐Related Cardiac Hypertrophy and the Expressions of Inflammatory Cytokines	8
Dexmedetomidine Inhibits Ferroptosis by Regulating the SRY‐Box Transcription Factor 9/Divalent Metal Transporter‐1 Axis to Alleviate Cerebral Ischemia/Reperfusion Injury	8
Computational prediction of Lee retention indices of polycyclic aromatic hydrocarbons by using machine learning	8
A single‐chain variable fragment‐anticancer lytic peptide (scFv‐ACLP) fusion protein for targeted cancer treatment	8
Systematic profiling of Taxol resistance and sensitivity to tubulin missence mutations at molecular and cellular levels	8
Bioinformatic Analysis of the Protective Effects of Dexmedetomidine and Thrombopoietin Against Hypoxia/Reoxygenation‐Induced Injury in AC16 Cells	7
Issue Information	7
Medicarpin suppresses proliferation and triggeres apoptosis by upregulation of BID, BAX, CASP3, CASP8, and CYCS in glioblastoma	7
Research progress on the P2X7 receptor in liver injury and hepatocellular carcinoma	7
Identification of 5‐(3‐(methylsulfonyl)phenyl)‐3‐(4‐(methylsulfonyl)phenyl)‐3H‐imidazo[4,5‐b]pyridine as novel orally bioavailable and metabolically stable antimalarial compou	7
Hsa‐miR‐503‐5p regulates CTDSPL to accelerate cisplatin resistance and angiogenesis of lung adenocarcinoma cells	7
Nesfatin‐1 Reduces Cholic Acid‐Induced Intrahepatic Cholestasis of Pregnancy by Regulating the General Control Nonderepressible 2/Eukaryotic Initiation Factor 2α Pathway	7
Spacered With Tetrazole Oleanolic and Ursolic Indolo‐Acids Are Strong Inhibitors of α‐Glucosidase	7
	7
Ferulic Acid Inhibits Partial Epithelial‐Mesenchymal Transition in Renal Tubular Epithelial Cells and Mitigates Renal Interstitial Fibrosis by Regulating the HIF‐1α/Twist Signaling Pathway	7
Design and Synthesis of 1,4‐Diformyl‐Piperazine Ferrostatin‐1 Derivatives as Novel Ferroptosis Inhibitors	7
Berberine attenuates cognitive dysfunction and hippocampal apoptosis in rats with prediabetes	7
Long noncoding RNA SNHG7‐miRNA‐mRNA axes crosstalk with oncogenic signaling pathways in human cancers	7
Preparation and antioxidant activity of phosphorylated polysaccharide from purple sweet potato	7
Study on the molecular mechanism of dihydromyricetin in alleviating liver cirrhosis based on network pharmacology	7
Puerarin Decreases the Expression of FUS‐Dependent MAPK4 to Inhibit the Development of Triple‐Negative Breast Cancer	7
Comment on “Integrative Analysis of Ex Vivo Studies and Microarray Reveals the Novel Inhibitor Effects of Trehalose on the Pathogenesis of Pterygium”	7
Discovering novel derivatives of STAT3 and HDAC inhibitors with anti‐tumor activity	7
	7
Extraction, chemical modification, and antioxidant activities of Daucus carota polysaccharide	7
Correction to Analysis of bioactive compounds using LC–ESI–MS/MS, cytotoxic, antimicrobial effects, and enzyme activities from Cyclotrichium origanifoliu	7
Discovery a series of novel inhibitors of human dihydroorotate dehydrogenase: Biological activity evaluation and molecular docking	7
Amentoflavone attenuates cell proliferation and induces ferroptosis in human gastric cancer by miR‐496/ATF2 axis	7
Propofol inhibits the proliferation, invasion, migration, and angiogenesis of oral squamous cell carcinoma through circ_0008898‐mediated pathway	7
Myoinositol and methyl stearate increases rifampicin susceptibility among drug‐resistant Mycobacterium tuberculosis expressing Rv1819c	7
Synthesis and Preliminary Anticancer Evaluation of 4‐C Derivatives of Diphyllin	7
In silico optimization of analogs derived pro‐adrenomedullin peptide to evaluate antimicrobial potential	7
Exendin‐4: A potential therapeutic strategy for Alzheimer's disease and Parkinson's disease	7
Development of potent inhibitors by fragment‐linking strategies	6
Design, Hemisynthesis, Characterization, Molecular Docking, and Dynamics Evaluation of Novel Totarol‐1,2,3‐Triazole Derivatives as Leishmaniasis and Toxoplasmosis Agents	6
Transition metal complexes of hydrazones as potential antimicrobial and anticancer agents: A short review	6
Anticancer properties and pharmaceutical applications of ginsenoside compound K: A review	6
Enhancer of zeste homolog 2 exerts functions in gastric cancer development via modulating microRNA‐222‐3p methylation and WEE1 expression	6
Quercetin inhibits breast cancer cell proliferation and survival by targeting Akt/mTOR/PTEN signaling pathway	6
Quinoline‐based heterocyclic hydrazones: Design, synthesis, anti‐plasmodial assessment, and mechanistic insights	6
Correction to “Nanoemulsion Based Lipid Nanoparticles for Effective Demethylcantharidin Delivery to Cure Liver Cancer”	6
Novel candidates in the clinical development pipeline for TB drug development and their synthetic approaches	6
Structural properties and immune‐enhancing activities of galactan isolated from red seaweed Grateloupia filicina	6
Pyrrole‐based EGFR inhibitors for the treatment of NCSLC: Binding modes and SARs investigations	6
Thienopyrimidine: Unveiling the Versatile Potential of a Promising Heterocyclic Scaffold in Drug Discovery	6
Some 2‐[4‐(1H‐benzimidazol‐1‐yl) phenyl]‐1H‐benzimidazole derivatives overcome imatinib resistance by induction of apoptosis and reduction of P‐glycoprotein activity	6
Ligand and structure based hierarchical virtual screening cascade for finding novel epidermal growth factor receptor inhibitors	6
Anti‐metastatic Effects of Bee Venom and Melittin in Breast Cancer Cells by Upregulation of BRMS1 and DRG1 Genes	6
Synthesis and Investigation of Peptide–Drug Conjugates Comprising Camptothecin and a Human Protein‐Derived Cell‐Penetrating Peptide	6
	6
Ganoderic acid A improves osteoarthritis by regulating RANKL/OPG ratio	6
A highly bioavailable curcumin formulation ameliorates inflammation cytokines and neurotrophic factors in mice with traumatic brain injury	6
Ginsenoside Rg3 alleviates the migration, invasion, and angiogenesis of lung cancer cells by inhibiting the expressions of cyclooxygenase‐2 and vascular endothelial growth factor	6
Synthesis and antiglycation activity of 3‐phenacyl substituted thiazolium salts, new analogs of Alagebrium	6
Acacetin restrains the malignancy of esophageal squamous carcinoma cells via regulating JAK2/STAT3 pathway	6
Cover Image	6
Formulation, optimization and characterization of raloxifene hydrochloride loaded PLGA nanoparticles by using Taguchi design for breast cancer application	6
Design and synthesis of isatin derivatives as effective SARS‐CoV‐2 3CL protease inhibitors	6
Role of calcium dysregulation in Alzheimer's disease and its therapeutic implications	6
Quinoline‐based thiazolidinone derivatives as potent cytotoxic and apoptosis‐inducing agents through EGFR inhibition	6
Structural modification of 2‐phenylquinoline‐4‐carboxylic acid containing SIRT3 inhibitors for the cancer differentiation therapy	6
Methyltransferase METTL3‐mediated maturation of miR‐4654 facilitates high glucose‐induced apoptosis and oxidative stress in lens epithelial cells via decreasing SOD2	6
An in silico comparative study of curcumin and 2‐deoxyuridine nucleoside derivatives: Reveals the role of angiogenin in ER stress‐induced apoptosis signaling	6
Arctigenin Modulates Adipogenic‐Osteogenic Balance in the Bone Marrow Microenvironment of Ovariectomized Rats via the MEK1/PPARγ/Wnt/β‐Catenin Pathway	6
Asiatic acid inhibits rheumatoid arthritis fibroblast‐like synoviocyte growth through the Nrf2/HO‐1/NF‐κB signaling pathway	6
Dehydroepiandrosterone‐α‐2‐Deoxyglucoside Exhibits Enhanced Anticancer Effects in MCF‐7 Breast Cancer Cells and Inhibits Glucose‐6‐Phosphate Dehydrogenase Activity	6
New pyrrolidine‐carboxamide derivatives as dual antiproliferative EGFR/CDK2 inhibitors	6
Cytotoxic activity of quinolinequinones in cancer: In vitro studies, molecular docking, and ADME/PK profiling	6
Curcumin affects apoptosis of colorectal cancer cells through ATF6‐mediated endoplasmic reticulum stress	6
Therapeutic potentials of N‐acetylcysteine immobilized polyrhodanine nanoparticles toward acetaminophen‐induced acute hepatotoxicity in rat	6
Nardosinone suppresses monoiodoacetate‐induced osteoarthritis in rats: The key role of the miR‐218‐5p/NUMB axis	6
Geraniol protects hippocampal CA1 neurons and improves functional outcomes in global model of stroke in rats	6
Baicalin mitigated IL‐1β‐Induced osteoarthritis chondrocytes damage through activating mitophagy	6
Downregulation of MDM2 by small interference RNA induces apoptosis and sensitizes MCF‐7 breast cells to resveratrol	6
Could natural terpenes be an alternative for the treatment of neglected tropical diseases?	6