OOIR: Observatory of International Research

Papers

(The TQCC of Expert Review of Gastroenterology & Hepatology is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
COVID-19 and hygiene hypothesis: increment of the inflammatory bowel diseases in next generation?	201
Managing pain in irritable bowel syndrome: current perspectives and best practice	79
Ripretinib for the treatment of adult patients with advanced gastrointestinal stromal tumors	75
Small bowel transplant – novel indications and recent progress	34
Imaging in pediatric disorders of the gut-brain interactions: current best practice and future directions	33
Prevention of pancreatitis after stent implantation for distal malignant biliary strictures: systematic review and meta-analysis	32
Differentiated/undifferentiated mixed type is a prognostic factor for T2/T3 gastric cancer patients	26
Virologic response maintenance and hepatocellular carcinoma in chronic hepatitis B patients treated with entecavir	25
Elucidating the role of extracellular vesicles in liver injury induced by HIV	24
Therapeutic drug monitoring in inflammatory bowel disease: recent developments	23
ERCP-related adverse events: incidence, mechanisms, risk factors, prevention, and management	21
Targeting liver metabolism: a pathway to cure hepatitis B virus?	21
Terlipressin in the management of adults with hepatorenal syndrome-acute kidney injury (HRS-AKI)	21
Familial intestinal polyposis and device assisted enteroscopy: where do we stand?	20
A narrative review on the diagnosis and management of constipation in infants	20
Lipid biomarkers in colorectal cancer, with particular emphasis on exosomes – current status and future inferences	19
Gender-related differences in celiac disease presentation and follow-up in adult patients	19
Early alpha-fetoprotein response predicts prognosis of immune checkpoint inhibitor and targeted therapy for hepatocellular carcinoma: a systematic review with meta-analysis	19
The assessment of impaired liver function and prognosis in hepatocellular carcinoma	19
Recent advances in treating constipation in children	17
Irritable bowel syndrome – controversies in diagnosis and management	17
Misinterpretation and misapplication of biomarkers in inflammatory bowel disease: how do we avoid this?	16
Biliary diversion in progressive familial intrahepatic cholestasis: a systematic review and meta-analysis	16
Bayesian analysis and the role of local palliative therapeutics for malignant biliary obstruction	16
Investigating the correlation between COVID-19 and the progression of chronic liver disease	16

Contemporary advances in the endoscopic management of cholangiocarcinoma: a review of accomplished milestones and prospective opportunities	15
An insight into Clostridioides difficile-associated diarrhea in Saudi children: diagnosis and treatment	15
Identification of a ferroptosis-related gene signature for predicting the prognosis of cholangiocarcinoma	15
Characteristic endoscopic findings in Helicobacter pylori diagnosis in clinical practice	14
Managing bile acid diarrhea: aspects of contention	14
Altered gut microbiota is associated with sleep disturbances in patients with minimal hepatic encephalopathy caused by hepatitis B-related liver cirrhosis	14
Preoperative endoscopic ultrasound-guided biliary drainage for primary drainage in obstructive jaundice	14
Recent updates on treatment options for primary follicular lymphoma of the gastrointestinal tract	14
Vitamin B12 deficiency and use of proton pump inhibitors: a systematic review and meta-analysis	14
Small bowel imaging in inflammatory bowel disease: updates for 2023	14
Impact of biologic therapies and small molecules on the risk of major adverse cardiovascular events in patients with inflammatory bowel diseases: systematic review and meta-analysis of randomized cont	13
Psychological distress in inflammatory bowel disease	13
Cost-effectiveness of tislelizumab plus chemotherapy vs chemotherapy as first-line treatment of PD-L1 positive advanced gastric or gastroesophageal junction adenocarcinoma from a Chinese perspective	13
IBD in women of reproductive age: where do novel therapies fit in?	13
Chronic nausea and vomiting: a diagnostic approach	13
Research progress in the role of gut microbiota and its metabolites in intrahepatic cholestasis of pregnancy	13
Evaluating the role of endoscopic ultrasound in pancreatitis	13
To STRIDE or not to STRIDE: a critique of “treat to target” in ulcerative colitis	13
Impact of the COVID-19 pandemic on hospitalizations with hepatocellular carcinoma in the United States	13
The role and function of CD4+ T cells in hepatic ischemia-reperfusion injury	12
An update on improving long-term outcomes for patients with chronic pancreatitis post-surgery	12
Managing pediatric Crohn’s disease: recent insights	12
Percutaneous endoscopic gastrostomy prior to esophagectomy for esophageal cancer – a systematic review and meta-analysis	12
Two-dimensional shear wave elastography for sparing endoscopy screening in patients with HBV-related compensated advanced chronic liver disease	12
Highlights of the drug-induced liver injury literature for 2021	11
Diagnosing eosinophilic esophagitis in pediatric patients	11
Managing complications of chronic pancreatitis: a guide for the gastroenterologist	11
Investigation of etiology-specific alterations in the gut microbiota in liver cirrhosis	11
Interrupting inflammatory bowel disease therapy: why, who, when and how to consider medication holidays	11
Relationship between pathogenic microorganisms and the occurrence of esophageal carcinoma based on pathological type: a narrative review	11
High platelet count predicts poor prognosis in HCC patients undergoing TACE: a propensity score-matched analysis	11
Artificial intelligence implementation in pancreaticobiliary endoscopy	11
Relief from behind: enemas, the back door enforcement to help treating chronic constipation in adults	11
Gastroesophageal reflux disease in preterm infants: unmet needs	11
Tenofovir versus entecavir on the prognosis of hepatitis B virus-related hepatocellular carcinoma: a systematic review and meta-analysis	10
Delivering adjuvant and neoadjuvant treatments in the early stages of hepatocellular carcinoma	10
The efficacy and safety of glucocorticoid for perioperative patients with hepatectomy: a systematic review and meta-analysis	9
An update on efficacy and safety comparison of biologics in treatment of inflammatory bowel disease targeting TNF-α, interleukins, leukocyte trafficking, Janus-kinase, and sphingosine-1-phosphate rece	9
Highlighting novel targets in immunotherapy for liver cancer	9
Modulating the microbiome in chronic liver diseases – current evidence on the role of fecal microbiota transplantation	9
Updates in interaction of gastroesophageal reflux disease and extragastroesophageal digestive diseases	9
Cytomegalovirus in ulcerative colitis: an evidence-based approach to diagnosis and treatment	9
Post-endoscopic submucosal dissection electrocoagulation syndrome: a clinical overview	9
Reply to letter to the Editor: Vitamin B12 deficiency and use of proton pump inhibitors: a systematic review and meta-analysis	9
Paraneoplastic syndromes in hepatocellular carcinoma: a review	9
EUS-guided gastro-enteral anastomosis for the treatment of gastric outlet obstruction: is the end of the enteral stent?	9
Germline testing and genetic counseling in biliary tract cancer: an operative proposal to improve the state of art	9
Towards a better diagnosis of gastro esophageal reflux disease	9
Management of disease-related abdominal abscesses in Crohn’s disease	8
Systematic mapping of worldwide research on intra-pancreatic fat deposition	8

Effects of probiotics on nonalcoholic fatty liver disease: a systematic review and meta-analysis	8
Cross-regulation between microRNAs and key proteins of signaling pathways in hepatocellular carcinoma	8
The TL1A inhibitors in IBD: what’s in the pot?	8
Assessment of efficacy and prognostic factors by Gelfoam for DEB-TACE in unresectable large hepatocellular carcinoma with portal vein tumor thrombus: a multi-center retrospective study	8
Acute severe ulcerative colitis: defining the precise moment for colectomy	8
Development and validation of modified Liaoning score for predicting the prognosis of liver cirrhosis: a retrospective, international multicenter, observational study	8
PSC patient with jaundice – should we ERCP?	8
Characterizing Crohn’s disease phenotypes through pan-enteric capsule endoscopy	8
Addition of thermal ablation to systemic chemotherapy for the treatment of unresectable intrahepatic cholangiocarcinoma: a propensity score matching analysis	7
Novel fibro-inflammatory biomarkers associated with disease activity in patients with Crohn’s disease	7
Autoimmune gastritis: an organ-specific disease or a model of systemic autoimmunity? Parallels, divergences, and emerging insights	7
Prioritization in inflammatory bowel disease therapy	7
Radiation safety and dose management in fluoroscopy-guided gastrointestinal procedures: current evidence and future perspectives	7
The position of anti-tumor necrosis factor agents for the treatment of adult patients with Crohn’s disease	7
Exploring immunological perturbations between hepatocellular carcinoma risk, inflammation and obesity	7
The association between deprivation and the incidence and survival of patients with hepatocellular carcinoma in the West of Scotland	7
Medical management of acute severe ulcerative colitis in the hospitalized patient	7
Nutritional aspects of inflammatory bowel disease	7
Grayscale ultrasonography findings for characterization of gallbladder wall thickening in non-acute setting: a systematic review and meta-analysis	7
Induction and maintenance of healing in erosive esophagitis in the United States	7
Primary biliary cholangitis: primary autoimmune disease or primary secretory defect	7
Nosocomial spontaneous bacterial peritonitis is associated with high mortality – a systematic review and meta-analysis	7
Innovations in the diagnosis, treatment, and management of disorders of gut-brain interaction (DGBI)	6
Reviewing novel findings and advances in diagnoses and treatment of primary biliary cholangitis	6
First-line immune checkpoint inhibitor-based combinations in unresectable hepatocellular carcinoma: current management and future challenges	6
A critical review of upadacitinib for the treatment of adults with moderately to severely active ulcerative colitis	6
Influence of metabolic dysfunction-associated fatty liver disease on the prognosis of patients with HBV-related acute-on-chronic liver failure	6
Recent developments in the diagnosis of pancreatic neuroendocrine neoplasms	6
Endoscopic ultrasound-guided pancreatic duct drainage: a comprehensive state of the art review	6
The meaning of R1 resection after endoscopic removal of gastric, duodenal and rectal neuroendocrine tumors	6
Histamine-producing bacteria and their role in gastrointestinal disorders	6
Proton beam therapy in the management of hepatocellular carcinoma	6
Adenoma detection rate in colonoscopy: how can it be improved?	6
The role of immunogenicity in optimizing biological therapies for inflammatory bowel disease	6
Analysis of the impact on efficacy of lubiprostone dose reduction to manage adverse events in the treatment of chronic constipation in Japan	6
2023 update on the clinical management of gastroparesis	6
Use of fiber-containing enteral formula in pediatric clinical practice: an expert opinion review	6
Noninvasive electrical neuromodulation for gastrointestinal motility disorders	6
Recent advances in the treatment of gastrointestinal motility disorders in children	6
Mistakes in managing hepatocellular carcinoma and how to avoid them: a narrative review	6