Chinese Medicine

Article	Citations
Fushenmu treatment ameliorates RyR2 with related metabolites in a zebrafish model of barium chloride induced arrhythmia	195
Correction: Magnolia kobus DC. suppresses neointimal hyperplasia by regulating ferroptosis and VSMC phenotypic switching in a carotid artery ligation mouse model	131
Metabolomics and proteomics analyses of Chrysanthemi Flos: a mechanism study of changes in proteins and metabolites by processing methods	105
Efficacy and compatibility mechanism of bear bile powder in Shexiang Tongxin dropping pills for acute myocardial infarction treatment	104
Paclitaxel combined with Compound K inducing pyroptosis of non-small cell lung cancer cells by regulating Treg/Th17 balance	102
An anti-inflammatory and anti-fibrotic proprietary Chinese medicine nasal spray designated as Allergic Rhinitis Nose Drops (ARND) with potential to prevent SARS-CoV-2 coronavirus infection by targetin	80
Liver metabolomics reveals potential mechanism of Jieduan-Niwan formula against acute-on-chronic liver failure (ACLF) by improving mitochondrial damage and TCA cycle	78
Pharmacological activity and clinical application analysis of traditional Chinese medicine ginger from the perspective of one source and multiple substances	72
Coix seed oil alleviates synovial angiogenesis through suppressing HIF-1α/VEGF-A signaling pathways via SIRT1 in collagen-induced arthritis rats	69
A comprehensive review on traditional uses, phytochemistry and pharmacological properties of Paeonia emodi Wall. ex Royle: current landscape and future perspectives	67
Quercetin inhibits caspase-1-dependent macrophage pyroptosis in experimental folic acid nephropathy	63
Shen-Zhi-Ling oral liquid ameliorates cerebral glucose metabolism disorder in early AD via insulin signal transduction pathway in vivo and in vitro	63
Effect of traditional chinese medicine (TCM) and its fermentation using Lactobacillus plantarum on ceftriaxone sodium-induced dysbacteriotic diarrhea in mice	61
Reporting quality of sham needles used as controls in acupuncture trials: a methodological evaluation	60
Exploring the active components and potential mechanisms of Rosa roxburghii Tratt in treating type 2 diabetes mellitus based on UPLC-Q-exactive Orbitrap/MS and network pharmacology	59
Myocardial protective effect and transcriptome profiling of Naoxintong on cardiomyopathy in zebrafish	55
Gastrodin attenuates diabetic cardiomyopathy characterized by myocardial fibrosis by inhibiting the KLK8-PAR1 signaling axis	55
Dipeptide PA3264 derived from rare and endangered Squama Manis is a novel bioactive peptide for the treatment of triple-negative breast cancer	53
From non-targeted to targeted GC–MS metabolomics strategy for identification of TCM preparations containing natural and artificial musk	49
Correction: Shengjiang San alleviated sepsis-induced lung injury through its bidirectional regulatory effect	48
Gegen-Sangshen oral liquid and its active fractions mitigate alcoholic liver disease in mice through repairing intestinal epithelial injury and regulating gut microbiota	43
Sodium tanshinone IIA sulfonate alleviates osteoarthritis through targeting SIRT1	41
Rhei Undulati Rhizoma attenuates memory decline and reduces amyloid-β induced neuritic dystrophy in 5xFAD mouse	41
An integrated approach for studying exposure, metabolism, and disposition of traditional Chinese medicine using PATBS and MDRB tools: a case study of semen Armeniacae Amarum	40
A strategy for selective screening of dual-target bioactive compounds against hypertrophic scar through inhibiting angiotensin II type 1 receptor while stimulating type 2 receptor from Chinese herbs	39

β-elemene promotes microglial M2-like polarization against ischemic stroke via AKT/mTOR signaling axis-mediated autophagy	39
A systematic review of the research progress of traditional Chinese medicine against pulmonary fibrosis: from a pharmacological perspective	37
Detumescence Analgesic Plaster mitigates knee osteoarthritis via active ingredients targeting mitochondrial complex 1/AMPK/MYL3-regulated cartilage homeostasis	37
Potential role of tea drinking in preventing hyperuricaemia in rats: biochemical and molecular evidence	36
UPLC-QTOF-MS with a chemical profiling approach for holistic quality evaluation between a material reference of Wen Dan decoction and its commercial preparations	36
An integrated study of Violae Herba (Viola philippica) and five adulterants by morphology, chemical compositions and chloroplast genomes: insights into its certified plant origin	35
Astragalus mongholicus Bunge and Curcuma aromatica Salisb. inhibits liver metastasis of colon cancer by regulating EMT via the CXCL8/CXCR2 axis and PI3K/AKT/mTOR signaling pathway	34
Advances in natural product anti-coronavirus research (2002-2022)	34
Bu Shen Huo Xue decoction promotes functional recovery in spinal cord injury mice by improving the microenvironment to promote axonal regeneration	33
Metabolomics and integrated network pharmacology analysis reveal SNKAF decoction suppresses cell proliferation and induced cell apoptisis in hepatocellular carcinoma via PI3K/Akt/P53/FoxO signaling ax	33
Psoralea corylifolia L.: a comprehensive review of its botany, traditional uses, phytochemistry, pharmacology, toxicology, quality control and pharmacokinetics	33
Clinical and economic analysis of Gastrodin injection for dizziness or vertigo: a retrospective cohort study based on electronic health records in China	33
Bushen-Yizhi formula ameliorates mitochondrial dysfunction and oxidative stress via AMPK/Sirt1 signaling pathway in D-gal-induced aging rats	32
Plant metabolomics: a new strategy and tool for quality evaluation of Chinese medicinal materials	31
Integrative network fusion-based multi-omics study for biomarker identification and patient classification of rheumatoid arthritis	31
Shen-Bai-Jie-Du decoction suppresses the progression of colorectal adenoma to carcinoma through regulating gut microbiota and short-chain fatty acids	30
Tongbi Huoluo Decoction alleviates cartilage degeneration in knee osteoarthritis by inhibiting degradation of extracellular matrix	29
Sea cucumber polypeptide ameliorates aging properties via the brain-gut axis in naturally aging mice	28
Acupuncture promotes muscle cells ATP metabolism in ST36 acupoint local exerting effect by activating TRPV1/CaMKII/AMPK/PGC1α signaling pathway	28
An exhaustive examination of the research progress in identifying potential JAK inhibitors from natural products: a comprehensive overview	28
Curcumin prevents As3+-induced carcinogenesis through regulation of GSK3β/Nrf2	27
Maimendong decoction and its active ingredient, ophiopogonin D, alleviate bleomycin-induced pulmonary fibrosis by regulating the behavior of lung fibroblasts	27
Correlation between quality and geographical origins of Leonuri Herba revealed by the qualitative fingerprint profiling and quantitative determination of chemical components	26
Correction: Bridging cultures: Chinese elements in scientific illustrations	26
Triptolide targets PPP2CA/ITGA5 axis to suppress lactate-driven ovarian cancer progression	25
Characterization of a novel polysaccharide from red ginseng and its ameliorative effect on oxidative stress injury in myocardial ischemia	25
Isolation, bioassay and 3D-QSAR analysis of 8-isopentenyl flavonoids from Epimedium sagittatum maxim. as PDE5A inhibitors	25
Efficacy and safety of oral Chinese patent medicines in the treatment of coronary heart disease combined with hyperlipidemia: a systematic review and network meta-analysis of 78 trials	25
Shuangshen Ningxin capsule alleviates myocardial ischemia–reperfusion injury in miniature pigs by modulating mitophagy: network pharmacology and experiments in vivo	25
Anti-inflammatory effects of anemonin on acute ulcerative colitis via targeted regulation of protein kinase C-θ	24
Traditional Chinese Medicine Shi-Bi-Man ameliorates psoriasis via inhibiting IL-23/Th17 axis and CXCL16-mediated endothelial activation	24
A new paradigm for drug discovery in the treatment of complex diseases: drug discovery and optimization	24
Z-ligustilide preferentially caused mitochondrial dysfunction in AML HL-60 cells by activating nuclear receptors NUR77 and NOR1	24
Effects and mechanisms of Zhizi Chuanxiong herb pair against atherosclerosis: an integration of network pharmacology, molecular docking, and experimental validation	24
Buyang Huanwu Decoction improves energy metabolism disorders after cerebral ischemia–reperfusion by regulating the SIRT1/AMPK signaling pathway to promote glycolysis and the tricarboxylic acid cycle	24
Qing-Kai-Ling oral liquid alleviates non-alcoholic fatty liver disease via remodeling gut microbiota and activating AMPK/ACC1 axis	24
Therapeutic potential of traditional Chinese medicine and mechanisms for the treatment of type 2 diabetes mellitus	24
Characterization of ginsenosides from Panax japonicus var. major (Zhu-Zi-Shen) based on ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry and desorption electros	23
Wu-Mei-Wan enhances brown adipose tissue function and white adipose browning in obese mice via upregulation of HSF1	23
Gegen-Qinlian decoction alleviates anxiety-like behaviors in methamphetamine-withdrawn mice by regulating Akkermansia and metabolism in the colon	23
A comprehensive review of Schisandra chinensis lignans: pharmacokinetics, pharmacological mechanisms, and future prospects in disease prevention and treatment	23
Extensive preclinical evaluation of combined mangiferin and glycyrrhizic acid for restricting synovial neovascularization in rheumatoid arthritis	23
Natural phytochemical-based strategies for antibiofilm applications	23
Asafoetida exerts neuroprotective effect on oxidative stress induced apoptosis through PI3K/Akt/GSK3β/Nrf2/HO-1 pathway	23
Electroacupuncture stimulation improves pulmonary fibrosis by modulating ferroptosis in rats: multiscale analysis of transcriptome and proteome	23
Revolutionizing Chinese medicine granule placebo with a machine learning four-color model	22
Effectiveness and safety research of Qingfei Paidu (QFPD) in treatment of COVID-19: an up-to-date systematic review and meta-analysis	22
Dendrobine ameliorates mitophagy-mediated endothelial senescence in diabetic kidney disease through activating the SIRT1/FOXO3a pathway	22
Three-dimensional visualization of electroacupuncture-induced activation of brown adipose tissue via sympathetic innervation in PCOS rats	22
Bojungikgi-tang improves skin barrier function and immune response in atopic dermatitis mice fed a low aryl hydrocarbon receptor ligand diet	22

Mechanism of drug-induced liver injury and hepatoprotective effects of natural drugs	22
Zedoary turmeric oil injection ameliorates lung inflammation via platelet factor 4 and regulates gut microbiota disorder in respiratory syncytial virus-infected young mice	22
Correction to: Effect of mineral excipients on processing traditional Chinese medicines: an insight into the components, pharmacodynamics and mechanism	21
A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment valida	21
Acupressure in patients with seasonal allergic rhinitis: a randomized controlled exploratory trial	21
Modified Qing-Zao-Jiu-Fei decoction attenuated pulmonary fibrosis induced by bleomycin in rats via modulating Nrf2/NF-κB and MAPKs pathways	21
Suxiao Jiuxin Pill alleviates myocardial ischemia–reperfusion injury through the ALKBH5/GSK3β/mTOR pathway	21
Two-dimensional code enables visibly mapping herbal medicine chemome: an application in Ganoderma lucidum	21
Total coumarins of Pileostegia tomentella induces cell death in SCLC by reprogramming metabolic patterns, possibly through attenuating β-catenin/AMPK/SIRT1	21
Comprehensive biomarker analysis of metabolomics in different syndromes in traditional Chinese medical for prediabetes mellitus	21
Combination of curcumin and piperine synergistically improves pain-like behaviors in mouse models of pain with no potential CNS side effects	21
Cayratia albifolia C.L.Li exerts anti-rheumatoid arthritis effect by inhibiting macrophage activation and neutrophil extracellular traps (NETs)	21
Santalum album L. alleviates cardiac function injury in heart failure by synergistically inhibiting inflammation, oxidative stress and apoptosis through multiple components	21
Ren-Shen-Bu-Qi decoction alleviates exercise fatigue through activating PI3K/AKT/Nrf2 pathway in mice	20
Acacetin alleviates autoimmune myocarditis by regulating CD4+ T cell mitochondrial respiration	20
Validation of the Cantonese version of the Traditional Chinese Medicine (TCM) Body constitution Questionnaire in elderly people	20
Anticancer perspective of 6-shogaol: anticancer properties, mechanism of action, synergism and delivery system	20
Identification of molecular targets of Hypericum perforatum in blood for major depressive disorder: a machine-learning pharmacological study	20
Effects of steam on polysaccharides from Polygonatum cyrtonema based on saccharide mapping analysis and pharmacological activity assays	20
Explore the potential mechanism of Huachansu injection against osteosarcoma via metabolomics, network pharmacology and bioinformatics	19
TCMNPAS: a comprehensive analysis platform integrating network formulaology and network pharmacology for exploring traditional Chinese medicine	19
Dianthi herba: a comprehensive review of its botany, traditional use, phytochemistry, and pharmacology	19
Correction: Traditional Chinese Medicine Shi-Bi-Man regulates lactic acid metabolism and drives hair follicle stem cell activation to promote hair regeneration	19
Electroacupuncture ameliorates inflammatory pain through CB2 receptor-dependent activation of the AMPK signaling pathway	19
Zishen Pill alleviates diabetes in Db/db mice via activation of PI3K/AKT pathway in the liver	19
Medicinal plants and natural products for treating overactive bladder	19
Astragalus membranaceus (Huangqi) and Rhizoma curcumae (Ezhu) decoction suppresses colorectal cancer via downregulation of Wnt5/β-Catenin signal	18
Correction: Saikosaponin D exerts antidepressant effect by regulating Homer1-mGluR5 and mTOR signaling in a rat model of chronic unpredictable mild stress	18
Uncover the anticancer potential of lycorine	18
Toddalolactone protects against osteoarthritis by ameliorating chondrocyte inflammation and suppressing osteoclastogenesis	18
Artificial intelligence-directed acupuncture: a review	18
Development of software enabling Chinese medicine-based precision treatment for osteoporosis at the gene and pathway levels	18
Poria cocos polysaccharides exert prebiotic function to attenuate the adverse effects and improve the therapeutic outcome of 5-FU in ApcMin/+ mice	18
TMT proteomics analysis reveals the mechanism of bleomycin-induced pulmonary fibrosis and effects of Ginseng honeysuckle superfine powdered tea	18
Schisandrin protects against ulcerative colitis by inhibiting the SGK1/NLRP3 signaling pathway and reshaping gut microbiota in mice	18
Huqi formula suppresses hepatocellular carcinoma growth by modulating the PI3K/AKT/mTOR pathway and promoting T cell infiltration	18
Development and validation of a quick screening tool for predicting neck pain patients benefiting from spinal manipulation: a machine learning study	18
Quantification of prevalence, clinical characteristics, co-existence, and geographic variations of traditional Chinese medicine diagnostic patterns via latent tree analysis-based differentiation rules	17
Cirsilineol inhibits RANKL-induced osteoclast activity and ovariectomy-induced bone loss via NF-κb/ERK/p38 signaling pathways	17
G protein-coupled receptors and traditional Chinese medicine: new thinks for the development of traditional Chinese medicine	17
Exocarpium Citri Grandis ameliorates alcoholic liver disease by modulation of hepatic lipid metabolism and iron homeostasis	17
Traditional Chinese medicine in diabetic kidney disease: multifaceted therapeutic mechanisms and research progress	17
Potential mechanisms of acupuncture treatment for rheumatoid arthritis: a study based on network topology and machine learning	17
Focus on T cell exhaustion: new advances in traditional Chinese medicine in infection and cancer	17
Electroacupuncture attenuates ferroptosis by promoting Nrf2 nuclear translocation and activating Nrf2/SLC7A11/GPX4 pathway in ischemic stroke	17
Integrating pharmacokinetics and network analysis to investigate the mechanism of Moutan Cortex in blood-heat and blood stasis syndrome	17
Tea and tea drinking: China’s outstanding contributions to the mankind	17
Involvement of the Sch9/Rim15/Msn2 signaling pathway in the anti-aging activity of dendrobine from Dendrobium nobile Lindl. via modification of oxidative stress and autophagy	17
The role of natural products targeting macrophage polarization in sepsis-induced lung injury	17
Identification of histone acetyltransferase genes responsible for cannabinoid synthesis in hemp	17
Salvianolic acid B promotes angiogenesis and inhibits cardiomyocyte apoptosis by regulating autophagy in myocardial ischemia	16
The tibetan medicine Zuozhu-Daxi can prevent Helicobacter pylori induced-gastric mucosa inflammation by inhibiting lipid metabolism	16
Zhuifeng Tougu capsules in the treatment of knee osteoarthritis (cold dampness obstruction syndrome): a randomized, double blind, multicenter clinical study	16
Saikosaponin D exerts antidepressant effect by regulating Homer1-mGluR5 and mTOR signaling in a rat model of chronic unpredictable mild stress	16
Efficacy and mechanisms of traditional Chinese medicine for COVID-19: a systematic review	16
A clinical experience-based Chinese herbal formula improves ethanol-induced drunken behavior and hepatic steatohepatitis in mice models	16
Temporal, spatial and demographic distributions characteristics of COVID-19 symptom clusters from chinese medicine perspective: a systematic cross-sectional study in China from 2019 to 2023	16
Traditional Chinese medicine use and risk of type 2 diabetes mellitus among patients with prediabetes: a population-based cohort study	16
Geniposide for treating atherosclerotic cardiovascular disease: a systematic review on its biological characteristics, pharmacology, pharmacokinetics, and toxicology	16
Huang-Lian-Jie-Du decoction alleviates cognitive impairment in periodontitis rats through restoring microbiota-gut-brain axis and inhibiting neuroinflammation via TLR4/NF-κB pathway	16
Unveiling correlations between aristolochic acids and liver cancer: spatiotemporal heterogeneity phenomenon	16
Acupuncture may play a key role in anti-depression through various mechanisms in depression	16
Identification of anti-fibrotic compounds from Piper longum L via hollow fiber cell fishing and high-performance liquid chromatography with in vivo and in vitro validation	16
Integrating knowledge graphs with ancient Chinese medicine classics: challenges and future prospects of multi-agent system convergence	16
Eryngium caeruleum: an update on ethnobotany, phytochemistry and biomedical applications	16
Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action	16
Traditional Chinese medicine promotes bone regeneration in bone tissue engineering	16
Effects of Shenling Baizhu powder on pyrotinib-induced diarrhea: analysis of gut microbiota, metabonomics, and network pharmacology	16
Research progress on antitumor mechanisms and molecular targets of Inula sesquiterpene lactones	15
Traditional Chinese medicine paraffin therapy: an evidence-based overview from a modern medicine perspective	15
Machine learning-assisted rapid determination for traditional Chinese Medicine Constitution	15
Variable importance for projection (VIP) scores for analyzing the contribution of risk factors in severe adverse events to Xiyanping injection	15
Two-dimensional cell membrane chromatography guided screening of myocardial protective compounds from Yindan Xinnaotong soft capsule	15
Thermal treatment enhances the resisting exercise fatigue effect of Phyllanthus emblica L.: novel evidence from tannin conversion in vitro, metabolomics, and gut microbiota community analysis	15
Formation of a traditional Chinese medicine self-assembly nanostrategy and its application in cancer: a promising treatment	15
Dual effect of aucubin on promoting VEGFR2 mediated angiogenesis and reducing RANKL-induced bone resorption	15
Filiform fire needling therapy relieves T cells-mediated melanocyte apoptosis and dysfunction by inhibiting JAK/STAT3 pathway via Mfsd4a in vitiligo	15
Natural products for enhancing the sensitivity or decreasing the adverse effects of anticancer drugs through regulating the redox balance	14
Liguzinediol potentiates the metabolic remodeling by activating the AMPK/SIRT3 pathway and represses Caspase-3/GSDME-mediated pyroptosis to ameliorate cardiotoxicity	14
Liriodendron attenuates intestinal fibrosis and inflammation in mice with radiation proctopathy	14

Multi-omics analysis reveals ACOT1 as the key target of piperine in Piper Longum-mediated gastric cancer treatment	14
Salvianolic acid B and Senkyunolide I synergistically alleviate cardiac hypertrophy and regulate MAP3K1 signaling	14
Honokiol acts as an AMPK complex agonist therapeutic in non-alcoholic fatty liver disease and metabolic syndrome	14
Association of lung-intestinal microecology and lung cancer therapy	14
Pharmacokinetic study of the main components of Tanreqing capsules and Tanreqing injections in beagles by liquid chromatography–tandem mass spectrometry	14
The effects of Chinese proprietary medicine and vaccination on patients with COVID-19: a retrospective study in Macao	14
Immunopotentiating effects of herb-partitioned moxibustion on the spleens of cyclophosphamide-induced immunosuppressed rats	14
Suppression of ferroptosis through the SLC7A11/glutathione/glutathione peroxidase 4 axis contributes to the therapeutic action of the Tangshenning formula on diabetic renal tubular injury	14
Gynostemma Pentaphyllum ameliorates CCl4-induced liver injury via PDK1/Bcl-2 pathway with comprehensive analysis of network pharmacology and transcriptomics	14
Cell and rat serum, urine and tissue metabolomics analysis elucidates the key pathway changes associated with chronic nephropathy and reveals the mechanism of action of rhein	14
Tanshinone IIA inhibits osteoclastogenesis in rheumatoid arthritis via LDHC-regulated ROS generation	14
Exploring the chemical components of Kuanchang-Shu granule and its protective effects of postoperative ileus in rats by regulating AKT/HSP90AA1/eNOS pathway	14
Correction to: Shen-Zhi-Ling oral liquid ameliorates cerebral glucose metabolism disorder in early AD via insulin signal transduction pathway in vivo and in vitro	14
Nrf2 mediates the effects of shionone on silica-induced pulmonary fibrosis	14
Curdione induces ferroptosis mediated by m6A methylation via METTL14 and YTHDF2 in colorectal cancer	13
Identification of key pharmacological components and targets for Aidi injection in the treatment of pancreatic cancer by UPLC-MS, network pharmacology, and in vivo experiments	13
Multi-omics driven paradigm for construction of traditional Chinese Medicine Zheng (syndrome) diagnosis and treatment model, taking Shi Zheng (syndrome of dampness) as an example	13
Wenshen Zhuanggu formula inhibits tumor-exosomes induced bone pre-metastasis niche formation in primary breast cancer mice	13
Uncovering the role of traditional Chinese medicine in immune-metabolic balance of gastritis from the perspective of Cold and Hot: Jin Hong Tablets as a case study	13
Therapeutic material basis and underling mechanisms of Shaoyao Decoction-exerted alleviation effects of colitis based on GPX4-regulated ferroptosis in epithelial cells	13
Mechanism of norcantharidin intervention in gastric cancer: analysis based on antitumor proprietary Chinese medicine database, network pharmacology, and transcriptomics	13
A computational-based new treatment strategy with three-armed RCT on Mycoplasma pneumoniae pneumonia in children	13
Aloin induced apoptosis by enhancing autophagic flux through the PI3K/AKT axis in osteosarcoma	13
Angelicin improves osteoporosis in ovariectomized rats by reducing ROS production in osteoclasts through regulation of the KAT6A/Nrf2 signalling pathway	13
Huang-Lian-Jie-Du decoction alleviates cognitive deficits in Alzheimer’s disease model 5xFAD mice by inhibiting Trem2/Dap12 signaling pathway	13
Multi-omics and network pharmacology approaches reveal the mechanism of action of KeKe tablet against post-infectious cough	13
Taraxerone inhibits M1 polarization and alleviates sepsis-induced acute lung injury by activating SIRT1	13