OOIR: Observatory of International Research

Papers

(The TQCC of Epigenomics is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Decoding the Year of 2023: Welcome to the 16th Volume of Epigenomics	51
DNMT3L Interacts with Piwi and Modulates the Expression of piRNAs in Transgenic Drosophila	44
Association between epigenetic aging and atrioventricular block: a two-sample Mendelian randomization study	41
Association between Alcohol Consumption and DNA Methylation in Blood: A Systematic Review of Observational Studies	27
A Comprehensive Bioinformatic Analysis of RanBP9 Expression and Its Relation to Prognosis in Human Breast Cancer	27
Altered epigenetic landscape as infectious disease diagnostics	24
Epigenetic alterations in prostate cancer: the role of chromatin remodeling	24
The Significance of Studying Functional Lncrna in Mouse Spermatogenesis	23
Lessons in Chromatin Organization and Gender Equity in Research: An Interview with Susan Gasser	22
Welcome to the 14thÂ Volume of Epigenomics	21
Epigenetic Signature of Exposure to Maternal Trypanosoma Cruzi Infection in Cord Blood Cells from Uninfected Newborns	20
From allergens to epigenetics: how histone acetylation shapes immune gene expression in allergic diseases	19
Cumulative psychosocial factors and epigenetic age acceleration in the Hispanic Community Health Study/Study of Latinos	19
Precision Epigenetics Provides a Scalable Pathway for Improving Coronary Heart Disease Care Globally	19
Epigenome-Wide Studies of Antipsychotics: A Systematic Review and Pathway Meta-Analysis	18
Unlocking the Epigenetic Symphony: Histone Acetylation’s Impact on Neurobehavioral Change in Neurodegenerative Disorders	18
Epigenetic rejuvenation: a journey backwards towards an epigenomic ground state	18
Epigenetics in evolution and adaptation to environmental challenges: pathways for disease prevention and treatment	18
Decoding Mitochondrial–Nuclear (epi)genome Interactions: The Emerging Role of ncRNAs	18
Alteration of the N ⁶ -Methyladenosine Epitranscriptomic Profile in Synthetic Phthalate-Treated Human Induced Pluripotent Stem Cell-Derived Endothelial Cells	17
Coregulatory effects of multiple histone modifications in key ferroptosis-related genes for lung adenocarcinoma	17
Comparison of Methylation Episignatures in KMT2B - and KMT2D -Related Human Disorders	17
The Study of HMOX1 DNA Methylation and Gene Expression and the Diagnostic Potential of miR-153-3p in Preeclampsia	16
The Impact and Mechanism of TET3 Overexpression on the Progression of Hepatic Fibrosis	16
Age-Related Changes in Sperm DNA Methylation and their Forensic and Clinical Implications	16

Targeting Tudor domains in leukemia: epigenetic insights for drug development	15
The Diagnostic Potential of the Epigenome in Autism Spectrum Disorders	15
Epigenetics and Cutaneous Neoplasms: From Mechanism to Therapy	15
Promotional Effects of HIF1α and KDM3A Interaction on Vascular Smooth Muscle Cells in Thoracic Aortic Dissection	15
The hMeDIP-Seq Identified INPP4A as a Novel Biomarker for Eosinophilic Chronic Rhinosinusitis with Nasal Polyps	15
How do Sphingolipids Play a Role in Epigenetic Mechanisms and Gene Expression?	14
Evaluating the Challenges and Reproducibility of Studies Investigating DNA Methylation Signatures of Psychological Stress	14
SET Protein as an Epigenetics Target	14
Phytochemicals in Cervical Cancer: An Epigenetic Overview	14
Blocking RPA-based methods for the determination of CpG methylation status and detection of gene mutations	13
Circular RNAs as multifaceted molecular regulators of vital activity and potential biomarkers of aging	13
Human RNA-Directed DNA Methylation Methylates High-Mobility Group Box 1 Protein-Produced DNA Gaps	13
Methylome of Skeletal Muscle Tissue in Patients with Hypertension and Diabetes Undergoing Cardiopulmonary Bypass	13
Harnessing the Role of Epigenetic Histone Modification in Targeting Head and Neck Squamous Cell Carcinoma	12
The eighth annual US DOHAD meeting: promising approaches in epigenetics research of early life exposures	12
Insights to aging prediction with AI based epigenetic clocks	12
Matched Analysis of Detailed Peripheral Blood and Tumor Immune Microenvironment Profiles in Bladder Cancer	11
High methylation of the same promoter of lncRNA ZNF582-AS1 / ZNF582 promotes malignant progression of esophageal cancer	11
Exploring the Molecular Targets for Type 2 Diabetes-Induced Alzheimer’s Disease Through Bioinformatics Analysis	11
Beadchip Technology to Detect DNA Methylation in Mouse Faithfully Recapitulates Whole-Genome Bisulfite Sequencing	11
POU2F2-mediated Upregulation of lncRNA PTPRG-AS1 Inhibits Ferroptosis in Breast Cancer Via miR-376c-3p/SLC7A11 Axis	11
EWAS in COPD by biomass-burning smoke exposure identifies low levels of endothelin-1 by hypermethylation of EDN1	11
The Epigenetics of Early Life Adversity and Trauma Inheritance: An Interview with Moshe Szyf	11
Chromatin Architecture Around Stroke Haplotypes Provides Evidence that Genetic Risk is Conferred Through Vascular Cells	11
Combined therapy targeting AR and EZH2 curbs castration-resistant prostate cancer enhancing anti-tumor T-cell response	11
Integrated epigenomic exposure signature discovery	11
Understanding Environmental Epigenomics in Autism Spectrum Disorder: An Interview with Farah R Zahir	11
The Prognostic Role of miR-31 in Colorectal Cancer: The Results of a Meta-Analysis of 4720 Patients	10
Role Of Epigenetic Drugs In Sensitizing Cancers To Anticancer Therapies: Emerging Trends And Clinical Advancements	10
Three generations of epigenetic clocks in mediating the adverse effect of smoking on metabolic health	10
Risks and Rewards of Big-Data in Epigenomics Research: An Interview with Melanie Ehrlich	10
microRNAs and their Therapeutic Strategy in Phase I and Phase II Clinical Trials	10
The epigenetics of frailty	10
ncRNAs as Biomarkers and Therapeutic Targets for Bronchiectasis	10
Dissecting the Nuances of Cancer Epigenomics in Liquid Biopsy	10
The epigenetic potential of vitamin K2 in brain health	9
m ⁶ A Modification and its Role in Neural Development and Neurological Diseases	9
Epigenetics and suicidal behavior in adolescents: a critical review	9
MiR-4732-3p Prevents Lung Cancer Progression via Inhibition of the TBX15/TNFSF11 Axis	9
Exploring Perinatal Biopsychosocial Factors and Epigenetic Age in 1-Year-Old Offspring	9
LINC01232 promotes ARNTL2 transcriptional activation and inhibits ferroptosis of CRC cells through p300/H3K27ac	9
The Science of Hope: An Interview with Randy Jirtle	8
Transcription Factors: A Potential Therapeutic Target in Head and Neck Squamous Cell Carcinoma	8
Combined replacement of lnc-MEG3 and miR-155 elicit tumor suppression in multiple myeloma	8
Epigenome-Wide Association Study of Serum Folate in Maternal Peripheral Blood Leukocytes	8
circPlekha7 suppresses renal fibrosis via targeting miR-493-3p/KLF4	8
The Role of N ⁶ -Methyladenosine RNA Modification in Platinum Resistance	8
METTL3 promotes Non-Small-Cell Lung Cancer Growth and Metastasis by Inhibiting FDX1 Through Copper Death-Associated Pri-miR-21-5p Maturation	8
Epigenetic Memory in Breast Cancer: Electrochemical Biosensor-Based Tracing of Histone H3 Acetylation Inheritance	8
Associations Between Grimage Acceleration and Pulmonary Function in the Coronary Artery Risk Development in Young Adults (CARDIA) Study	8

Mitochondrial D-loop Methylation Levels Inversely Correlate with Disease Duration in Amyotrophic Lateral Sclerosis	8
cfDNA Methylation in Liquid Biopsies as Potential Testicular Seminoma Biomarker	7
DNA methylation associations with cognitive function in early-stage hormone receptor-positive breast cancer patients	7
Dna Methylation as a Powerful Tool to Investigate the Biology and Pathology of Aging	7
Psychiatry and sensation: the epigenetic links	7
Constructed Competitive Endogenous RNA Network and Patterns of Immune Infiltration Revealing the Prognostic Signature for Cervical Cancer	7
Mom genes and dad genes: genomic imprinting in the regulation of social behaviors	7
The Epigenetic Landscape: How Environmental Cues Shape Gene Expression	7
Epigenetic extracellular vesicle-based biomarkers for urological malignancies: is the hope worth the hype?	7
Epigenomics and Health Disparities	7
Dysregulation of epigenetic modifications in inborn errors of immunity	7
Integrative analysis of a novel 5 methylated snoRNA genes prognostic signature in patients with glioma	7
Dulaglutide as a Demethylating Agent to Improve the Outcome of Breast Cancer	7
The regulation of microRNAs on chemoresistance in triple-negative breast cancer: a recent update	6
Cell-free DNA methylation patterns in aging and their association with inflamm-aging	6
PTEN Promoter Methylation And Expression In Endometrial Cancer Tissues	6
Correlation among maternal risk factors, gene methylation and disease severity in females with autism spectrum disorder	6
Dna Methylation Episignatures are Sensitive and Specific Biomarkers for Detection of Patients with Kat6A / Kat6B Variants	6
Epigenetic Regulation of Vitamin D Deficiency	6
Could unlocking methylation-based blood cell counts revolutionize epidemiology?	6
Combination Therapy and Noncoding RNAs: A New Era of Cancer Personalized Medicine	6
Bridging the gap: R-loop mediated genomic instability and its implications in neurological diseases	6
The Epigenetics Orchestra of Notch Signaling: A Symphony for Cancer Therapy	6
Epigenetics: the missing link between environmental exposures and Parkinson's disease?	6
A narrative review of epigenetic marker in H3K27ac and its emerging potential as a therapeutic target in cancer	6
Epigenetic Disruption of Histone Deacetylase-2 Accelerated Apoptotic Signaling and Retarded Malignancy in Gastric Cells	6
The Role of H3K9 Acetylation and Gene Expression in Different Brain Regions of Alzheimer’s Disease Patients	6
tRNA-derived RNAs in human milk extracellular vesicles and associations with breastfeeding variables and maternal diet	6
Epigenetics of cerebrovascular diseases: an update review of clinical studies	6
Association between imprinting disorders and assisted reproductive technologies	6
Epigenetic landscape of intestinal cell line HT29 cocultured with Lacticaseibacillus	6
RASSF1A Promotes ATM Signaling and RASSF1A Methylation is a Synthetic Lethal Marker for ATR Inhibitors	6
EpigenomIc Technologies: An Interview with Jörg Tost	6
Impact of prematurity on LINE-1 promoter methylation	6
Development and validation of a novel cell type estimation method for targeted bisulfite sequencing data	6
Current trends in clinical trials and the development of small molecule epigenetic inhibitors as cancer therapeutics	5
Accurate interpretation of inosines in RNAs: recognized as G is more than basepairing with C	5
Epigenomic mechanisms of dietary prescriptions for obesity therapy	5
DNA methylation-based health predictors: advances, applications, and perspectives	5
Epigenomic Impacts of Meditative Practices	5
Deciphering KDM8 dysregulation and CpG methylation in hepatocellular carcinoma using multi-omics and machine learning	5
Introducing the Research Article Reporting Checklist for Bioinformatic and Data Re-Analysis Studies	5
DNA Methylation as a Window into Female Reproductive Aging	5
Transcriptome Profiling and ceRNA Network of Small Extracellular Vesicles from Resting and Degranulated Mast Cells	5
Breaking the epigenetic code with MARCS: the Modification Atlas of Regulation by Chromatin States	5
Placental expression and methylation of angiogenic factors in assisted reproductive technology pregnancies from India	5
The Ups and Downs of DNA Methylation: An Interview with Gerd Pfeifer	5
SIX4 , a Potential Therapeutic Target for Estrogen Receptor-Positive Breast Cancer Patients, is Associated with low Promoter Methylation Level	5
Environmental aging: through the prism of DNA methylation	5
Methylated Ccfdna from Plasma Biomarkers of Alzheimer’s Disease Using Targeted Bisulfite Sequencing	5
Stress and Spirituality in Relation to HPA Axis Gene Methylation Among US Black women: Results from the Black Women’s Health Study and the Study on Stress, Spirituality and Health	5
PEMT Variants are Associated with Nonsyndromic Cleft Lip with or without Cleft Palate in Chile	5
Clinical Uses of Epigenetics in Cardiology and Cardiothoracic Surgery: An Update	5
Comprehensive Analysis of Epigenetic Modifications and Immune-Cell Infiltration In Tissues from Patients With Systemic Lupus Erythematosus	5
Super-enhancers: drivers of cells’ identities and cells’ debacles	5
The mystique of epigenetic regulation: the remarkable case of a human noncoding RNA, nc886	5
Methylation changes of liver DNA during the formation of gallstones	5