OOIR: Observatory of International Research

Papers

(The TQCC of Epigenomics is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)

Article	Citations
DNMT3L Interacts with Piwi and Modulates the Expression of piRNAs in Transgenic Drosophila	53
Decoding the Year of 2023: Welcome to the 16th Volume of Epigenomics	45
Epigenetics in evolution and adaptation to environmental challenges: pathways for disease prevention and treatment	42
Association between epigenetic aging and atrioventricular block: a two-sample Mendelian randomization study	29
Precision Epigenetics Provides a Scalable Pathway for Improving Coronary Heart Disease Care Globally	28
Association between Alcohol Consumption and DNA Methylation in Blood: A Systematic Review of Observational Studies	26
From allergens to epigenetics: how histone acetylation shapes immune gene expression in allergic diseases	24
Unlocking the Epigenetic Symphony: Histone Acetylation’s Impact on Neurobehavioral Change in Neurodegenerative Disorders	24
Epigenetic Signature of Exposure to Maternal Trypanosoma Cruzi Infection in Cord Blood Cells from Uninfected Newborns	24
The Significance of Studying Functional Lncrna in Mouse Spermatogenesis	23
Welcome to the 14thÂ Volume of Epigenomics	20
Lessons in Chromatin Organization and Gender Equity in Research: An Interview with Susan Gasser	20
Altered epigenetic landscape as infectious disease diagnostics	19
Cumulative psychosocial factors and epigenetic age acceleration in the Hispanic Community Health Study/Study of Latinos	19
A Comprehensive Bioinformatic Analysis of RanBP9 Expression and Its Relation to Prognosis in Human Breast Cancer	19
SET Protein as an Epigenetics Target	19
Epigenetic alterations in prostate cancer: the role of chromatin remodeling	19
Coregulatory effects of multiple histone modifications in key ferroptosis-related genes for lung adenocarcinoma	19
Epigenome-Wide Studies of Antipsychotics: A Systematic Review and Pathway Meta-Analysis	18
Epigenetic rejuvenation: a journey backwards towards an epigenomic ground state	18
Decoding Mitochondrial–Nuclear (epi)genome Interactions: The Emerging Role of ncRNAs	18
Epigenetics and Cutaneous Neoplasms: From Mechanism to Therapy	17
Alteration of the N ⁶ -Methyladenosine Epitranscriptomic Profile in Synthetic Phthalate-Treated Human Induced Pluripotent Stem Cell-Derived Endothelial Cells	17
The Study of HMOX1 DNA Methylation and Gene Expression and the Diagnostic Potential of miR-153-3p in Preeclampsia	16
The Impact and Mechanism of TET3 Overexpression on the Progression of Hepatic Fibrosis	16

Targeting Tudor domains in leukemia: epigenetic insights for drug development	16
The hMeDIP-Seq Identified INPP4A as a Novel Biomarker for Eosinophilic Chronic Rhinosinusitis with Nasal Polyps	16
The Diagnostic Potential of the Epigenome in Autism Spectrum Disorders	15
Phytochemicals in Cervical Cancer: An Epigenetic Overview	15
Promotional Effects of HIF1α and KDM3A Interaction on Vascular Smooth Muscle Cells in Thoracic Aortic Dissection	15
How do Sphingolipids Play a Role in Epigenetic Mechanisms and Gene Expression?	15
Age-Related Changes in Sperm DNA Methylation and their Forensic and Clinical Implications	15
Methylome of Skeletal Muscle Tissue in Patients with Hypertension and Diabetes Undergoing Cardiopulmonary Bypass	14
Comparison of Methylation Episignatures in KMT2B - and KMT2D -Related Human Disorders	14
Human RNA-Directed DNA Methylation Methylates High-Mobility Group Box 1 Protein-Produced DNA Gaps	13
Evaluating the Challenges and Reproducibility of Studies Investigating DNA Methylation Signatures of Psychological Stress	13
EWAS in COPD by biomass-burning smoke exposure identifies low levels of endothelin-1 by hypermethylation of EDN1	13
High methylation of the same promoter of lncRNA ZNF582-AS1 / ZNF582 promotes malignant progression of esophageal cancer	13
Blocking RPA-based methods for the determination of CpG methylation status and detection of gene mutations	12
The eighth annual US DOHAD meeting: promising approaches in epigenetics research of early life exposures	12
Harnessing the Role of Epigenetic Histone Modification in Targeting Head and Neck Squamous Cell Carcinoma	12
Circular RNAs as multifaceted molecular regulators of vital activity and potential biomarkers of aging	12
Insights to aging prediction with AI based epigenetic clocks	12
The epigenetics of frailty	11
Exploring the Molecular Targets for Type 2 Diabetes-Induced Alzheimer’s Disease Through Bioinformatics Analysis	11
Matched Analysis of Detailed Peripheral Blood and Tumor Immune Microenvironment Profiles in Bladder Cancer	11
Three generations of epigenetic clocks in mediating the adverse effect of smoking on metabolic health	11
Combined therapy targeting AR and EZH2 curbs castration-resistant prostate cancer enhancing anti-tumor T-cell response	11
The Prognostic Role of miR-31 in Colorectal Cancer: The Results of a Meta-Analysis of 4720 Patients	11
Role Of Epigenetic Drugs In Sensitizing Cancers To Anticancer Therapies: Emerging Trends And Clinical Advancements	11
POU2F2-mediated Upregulation of lncRNA PTPRG-AS1 Inhibits Ferroptosis in Breast Cancer Via miR-376c-3p/SLC7A11 Axis	11
Chromatin Architecture Around Stroke Haplotypes Provides Evidence that Genetic Risk is Conferred Through Vascular Cells	10
The Epigenetics of Early Life Adversity and Trauma Inheritance: An Interview with Moshe Szyf	10
Risks and Rewards of Big-Data in Epigenomics Research: An Interview with Melanie Ehrlich	10
Dissecting the Nuances of Cancer Epigenomics in Liquid Biopsy	10
microRNAs and their Therapeutic Strategy in Phase I and Phase II Clinical Trials	10
Beadchip Technology to Detect DNA Methylation in Mouse Faithfully Recapitulates Whole-Genome Bisulfite Sequencing	10
Blood-based DNA methylation markers for autism spectrum disorder identification using machine learning	10
ncRNAs as Biomarkers and Therapeutic Targets for Bronchiectasis	10
MiR-4732-3p Prevents Lung Cancer Progression via Inhibition of the TBX15/TNFSF11 Axis	9
Epigenetics and suicidal behavior in adolescents: a critical review	9
LINC01232 promotes ARNTL2 transcriptional activation and inhibits ferroptosis of CRC cells through p300/H3K27ac	9
Integrated epigenomic exposure signature discovery	9
Associations Between Grimage Acceleration and Pulmonary Function in the Coronary Artery Risk Development in Young Adults (CARDIA) Study	9
m ⁶ A Modification and its Role in Neural Development and Neurological Diseases	9
The Science of Hope: An Interview with Randy Jirtle	8
circPlekha7 suppresses renal fibrosis via targeting miR-493-3p/KLF4	8
Exploring Perinatal Biopsychosocial Factors and Epigenetic Age in 1-Year-Old Offspring	8
Mitochondrial D-loop Methylation Levels Inversely Correlate with Disease Duration in Amyotrophic Lateral Sclerosis	8
Epigenome-Wide Association Study of Serum Folate in Maternal Peripheral Blood Leukocytes	8
DNA methylation profile to aid in the diagnosis of pancreatic ductal adenocarcinoma and its role in disease progression	8
Transcription Factors: A Potential Therapeutic Target in Head and Neck Squamous Cell Carcinoma	8
Combined replacement of lnc-MEG3 and miR-155 elicit tumor suppression in multiple myeloma	8
Epigenetic Memory in Breast Cancer: Electrochemical Biosensor-Based Tracing of Histone H3 Acetylation Inheritance	8
The epigenetic potential of vitamin K2 in brain health	8

METTL3 promotes Non-Small-Cell Lung Cancer Growth and Metastasis by Inhibiting FDX1 Through Copper Death-Associated Pri-miR-21-5p Maturation	7
Epigenomics and Health Disparities	7
Association between imprinting disorders and assisted reproductive technologies	7
Integrative analysis of a novel 5 methylated snoRNA genes prognostic signature in patients with glioma	7
Constructed Competitive Endogenous RNA Network and Patterns of Immune Infiltration Revealing the Prognostic Signature for Cervical Cancer	7
Dysregulation of epigenetic modifications in inborn errors of immunity	7
Psychiatry and sensation: the epigenetic links	7
cfDNA Methylation in Liquid Biopsies as Potential Testicular Seminoma Biomarker	7
The Role of N ⁶ -Methyladenosine RNA Modification in Platinum Resistance	7
Epigenetic extracellular vesicle-based biomarkers for urological malignancies: is the hope worth the hype?	7
Mom genes and dad genes: genomic imprinting in the regulation of social behaviors	7
DNA methylation associations with cognitive function in early-stage hormone receptor-positive breast cancer patients	6
EpigenomIc Technologies: An Interview with Jörg Tost	6
PTEN Promoter Methylation And Expression In Endometrial Cancer Tissues	6
Epigenetics: the missing link between environmental exposures and Parkinson's disease?	6
Cell-free DNA methylation patterns in aging and their association with inflamm-aging	6
Epigenetic landscape of intestinal cell line HT29 cocultured with Lacticaseibacillus	6
Epigenetic Disruption of Histone Deacetylase-2 Accelerated Apoptotic Signaling and Retarded Malignancy in Gastric Cells	6
Dna Methylation as a Powerful Tool to Investigate the Biology and Pathology of Aging	6
Epigenetics of cerebrovascular diseases: an update review of clinical studies	6
Correlation among maternal risk factors, gene methylation and disease severity in females with autism spectrum disorder	6
The Epigenetic Landscape: How Environmental Cues Shape Gene Expression	6
The regulation of microRNAs on chemoresistance in triple-negative breast cancer: a recent update	6
Combination Therapy and Noncoding RNAs: A New Era of Cancer Personalized Medicine	6
Dna Methylation Episignatures are Sensitive and Specific Biomarkers for Detection of Patients with Kat6A / Kat6B Variants	6
Dulaglutide as a Demethylating Agent to Improve the Outcome of Breast Cancer	6
RASSF1A Promotes ATM Signaling and RASSF1A Methylation is a Synthetic Lethal Marker for ATR Inhibitors	6
The Epigenetics Orchestra of Notch Signaling: A Symphony for Cancer Therapy	6
The Role of H3K9 Acetylation and Gene Expression in Different Brain Regions of Alzheimer’s Disease Patients	6
A narrative review of epigenetic marker in H3K27ac and its emerging potential as a therapeutic target in cancer	6
Super-enhancers: drivers of cells’ identities and cells’ debacles	5
tRNA-derived RNAs in human milk extracellular vesicles and associations with breastfeeding variables and maternal diet	5
Bridging the gap: R-loop mediated genomic instability and its implications in neurological diseases	5
Impact of prematurity on LINE-1 promoter methylation	5
Transcriptome Profiling and ceRNA Network of Small Extracellular Vesicles from Resting and Degranulated Mast Cells	5
Methylation changes of liver DNA during the formation of gallstones	5
Performance Comparisons of Methylation and Structural Variants From Low-Input Whole-Genome Methylation Sequencing	5
Clinical Uses of Epigenetics in Cardiology and Cardiothoracic Surgery: An Update	5
PEMT Variants are Associated with Nonsyndromic Cleft Lip with or without Cleft Palate in Chile	5
Could unlocking methylation-based blood cell counts revolutionize epidemiology?	5
Epigenetic Regulation of Vitamin D Deficiency	5
The Ups and Downs of DNA Methylation: An Interview with Gerd Pfeifer	5
mRNA Modifications: Clinical Clarification and Significance	5
Epigenomic Impacts of Meditative Practices	5
Development and validation of a novel cell type estimation method for targeted bisulfite sequencing data	5
Accurate interpretation of inosines in RNAs: recognized as G is more than basepairing with C	5
Epigenomic mechanisms of dietary prescriptions for obesity therapy	5
DNA methylation-based health predictors: advances, applications, and perspectives	5
Breaking the epigenetic code with MARCS: the Modification Atlas of Regulation by Chromatin States	5
Placental expression and methylation of angiogenic factors in assisted reproductive technology pregnancies from India	5
Deciphering KDM8 dysregulation and CpG methylation in hepatocellular carcinoma using multi-omics and machine learning	5
Comprehensive Analysis of Epigenetic Modifications and Immune-Cell Infiltration In Tissues from Patients With Systemic Lupus Erythematosus	5
MDM2 and DNMT1 inhibitors induce neuroblastoma cell death through p53-dependent and independent pathways	5