OOIR: Observatory of International Research

Papers

(The TQCC of Epigenomics is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Association between epigenetic aging and atrioventricular block: a two-sample Mendelian randomization study	39
A narrative review of epigenetic marker in H3K27ac and its emerging potential as a therapeutic target in cancer	35
LncRNA H19 Promotes Tumor Angiogenesis in Smokers by Targeting Anti-Angiogenic MiRNAs	31
Integrated Analysis Revealing the Role Of TET3-Mediated MUC13 Promoter Hypomethylation in Hepatocellular Carcinogenesis	26
Retraction: Inhibition of CTCF-Regulated miRNA-185-5p Mitigates Renal Interstitial Fibrosis of Chronic Kidney Disease	23
Histone Deacetylase 6: At the Interface of Cancer and Neurodegeneration	22
The Era of Biomarkers and Precision Medicine in Colorectal Cancer: An Interview with Ajay Goel	21
Apoptosis And Myocardial Infarction: Role Of Ncrnas And Exosomal Ncrnas	21
Lessons in Chromatin Organization and Gender Equity in Research: An Interview with Susan Gasser	20
Secretion of Acetylated Amino Acids by Drug-Induced Cancer Cells: Perspectives on Metabolic-Epigenetic Alterations	20
Epigenetics of cerebrovascular diseases: an update review of clinical studies	20
HAR1 : An Insight Into lncRNA Genetic Evolution	19
miR-498 inhibits autophagy and M2-like polarization of tumor-associated macrophages in esophageal cancer via MDM2/ATF3	19
Combination Therapy and Noncoding RNAs: A New Era of Cancer Personalized Medicine	19
Epigenetic Regulation of Vitamin D Deficiency	18
Welcome to the 14thÂ Volume of Epigenomics	18
Epigenetic Signature of Exposure to Maternal Trypanosoma Cruzi Infection in Cord Blood Cells from Uninfected Newborns	18
Decoding the Year of 2023: Welcome to the 16th Volume of Epigenomics	17
DNA Methylation Detection Technology and Plasma-Based Methylation Biomarkers in Screening of Gastrointestinal Carcinoma	17
Gestational Sleep Apnea Perturbations Induce Metabolic Disorders by Divergent Epigenomic Regulation	16
Precision Epigenetics Provides a Scalable Pathway for Improving Coronary Heart Disease Care Globally	16
Altered epigenetic landscape as infectious disease diagnostics	16
EpigenomIc Technologies: An Interview with Jörg Tost	16
Statin therapy is associated with epigenetic modifications in individuals with Type 2 diabetes	15
The Significance of Studying Functional Lncrna in Mouse Spermatogenesis	15

DNA methylation episignatures: insight into copy number variation	15
Epigenetics-Based Diagnostic and Therapeutic Strategies: Shifting the Paradigm in Prostate Cancer	14
Association between Alcohol Consumption and DNA Methylation in Blood: A Systematic Review of Observational Studies	14
Genome-wide Methylation Analysis of Post-Mortem Cerebellum Samples Supports the Role of Peroxisomes in Autism Spectrum Disorder	14
Bridging the gap: R-loop mediated genomic instability and its implications in neurological diseases	13
Epigenetic landscape of intestinal cell line HT29 cocultured with Lacticaseibacillus	13
DNMT3L Interacts with Piwi and Modulates the Expression of piRNAs in Transgenic Drosophila	13
A Comprehensive Bioinformatic Analysis of RanBP9 Expression and Its Relation to Prognosis in Human Breast Cancer	13
Epigenetic Studies of Child Neurodevelopment: What can we Learn from a Developmental Science Perspective?	13
Novel epigenetic roles of lactylation in osteogenesis	13
Influence of Antidepressant Drugs on DNA Methylation of Ion Channels Genes in Blood Cells of Psychiatric Patients	13
Epigenetic identification of LTBP4 as a putative tumor suppressor in breast cancer	13
A method of sample-wise region-set enrichment analysis for DNA methylomics	12
Epigenetic Disruption of Histone Deacetylase-2 Accelerated Apoptotic Signaling and Retarded Malignancy in Gastric Cells	12
The Role of H3K9 Acetylation and Gene Expression in Different Brain Regions of Alzheimer’s Disease Patients	12
Pathological Epigenetic Events and Reversibility Review: the Intersection between Hallmarks of Aging and Developmental Origin of Health and Disease	12
A Step Towards Understanding Disparities – Linking Race, Ancestry, Epigenetics and Pain	12
Dna Methylation Episignatures are Sensitive and Specific Biomarkers for Detection of Patients with Kat6A / Kat6B Variants	12
Epigenetic Signature Discriminates Lymphatic Metastasis in BRAF Wild-Type Thyroid Carcinoma: Methylation Role of GRIK2	11
DNA methylation in chronic obstructive pulmonary disease	11
Prenatal Neun+ Neurons of Down Syndrome Display Aberrant Integrative DNA Methylation and Gene Expression Profiles	11
Identification of Potential Differentially Methylated Gene-Related Biomarkers in Endometriosis	11
The regulation of microRNAs on chemoresistance in triple-negative breast cancer: a recent update	11
Fatty Acid Metabolism-Related lncRNA Prognostic Signature for Serous Ovarian Carcinoma	11
Toxicoepigenetic Consequences of Fumonisin B ₁ Exposure: Current Knowledge and Future Perspective	11
Global DNA Hypomethylation and the Expression Profile of DNA Methyltransferase Genes in Late-Onset Neonatal Sepsis	11
The Conundrum of the Functional Relationship Between Transcription Factors and Chromatin	11
Leveraging Epigenetics to Enhance the Efficacy of Cancer-Testis Antigen: A Potential Candidate for Immunotherapy	11
Exploring the Pathogenesis and Treatment of IgA Nephropathy Based on Epigenetics	11
SPARCL1 Exhibits Different Expressions in Left- and Right-Sided Colon Cancer and is Downregulated Via DNA Methylation	11
A novel subtype to predict prognosis and treatment response with DNA driver methylation–transcription in ovarian cancer	11
A novel chromatin regulator signature predicts the prognosis, clinical features and immunotherapy of colon cancer	11
Hypomethylation of Wnt Signaling Regulator Genes in Developmental Language Disorder	11
Methylation Quantitative Trait Locus Analysis of Chronic Postsurgical Pain Uncovers Epigenetic Mediators of Genetic Risk	10
The Link Between 5-Hydroxymethylcytosine and DNA Demethylation in Early Embryos	10
Mycotoxins Exacerbate HIV Infection: The Potential of N ⁶ -Methyladenosine RNA Methylation	10
Gut Microbiota and Epigenetics in Colorectal Cancer: Implications for Carcinogenesis and Therapeutic Intervention	10
Role of Epigenetics in Pancreatic Ductal Adenocarcinoma	10
Epigenomics May Begin To Explain In Vitro Differential Response To Hypomethylating Agents In MMR-D Hypermethylated Endometrial Cancer	10
Specific Epigenetic age Acceleration Patterns Among Four Molecular Subtypes of Gastric Cancer and their Prognostic Value	10
Changes of BDNF exon IV DNA methylation are associated with methamphetamine dependence	9
Epigenetics in evolution and adaptation to environmental challenges: pathways for disease prevention and treatment	9
Toward a more holistic approach to the study of exposures and child outcomes	9
Emerging Functions and Roles of circRNAs in Cancer	9
Unlocking the Epigenetic Symphony: Histone Acetylation’s Impact on Neurobehavioral Change in Neurodegenerative Disorders	9
FAM81A Identified as a Stemness-Related Gene by Screening DNA Methylation Sites Based on Machine Learning-Accessed Stemness in Pancreatic Cancer	9
CRISPR-Based Epigenome Editing: Mechanisms and Applications	9
Circulating non-coding RNAs as a tool for liquid biopsy in solid tumors	9
Super-enhancers: drivers of cells’ identities and cells’ debacles	8
lncRNA TUG1 as Potential Novel Biomarker for Prognosis of Cardiovascular Diseases	8

Epitranscriptomic Analysis of m ⁶ A Methylome in Rats after Lumbosacral Nerve Root Avulsion	8
Breaking the epigenetic code with MARCS: the Modification Atlas of Regulation by Chromatin States	8
Edge of RNA m6A modification on LINE-1 retrotransposons in central nervous system: merely a transcriptional control?	8
Potential epigenetic markers of clinical diagnostics/therapeutic targets in preeclampsia	8
Complex Cross-Talk between EZH2 and Mirnas Confers Hallmark Characteristics and Shapes the Tumor Microenvironment	7
Clinical Uses of Epigenetics in Cardiology and Cardiothoracic Surgery: An Update	7
Mirnas as Biomarkers of Musculoskeletal Pain in Long-Distance Runners: The Mimus Study Protocol	7
Detection of an intestinal cell DNA methylation signature in blood samples from neonates with necrotizing enterocolitis	7
Cellular and epigenetic perspective of protein stability and its implications in the biological system	7
Development and validation of a novel cell type estimation method for targeted bisulfite sequencing data	7
Epigenomic mechanisms of dietary prescriptions for obesity therapy	7
Hsa_Circ_0092339 Acts as a Molecular Sponge in Castration-Resistant Prostate Cancer via the Hsa-Mir-940/ C-MYC Axis	7
Epigenetic Mechanisms Underpinning Sexual Dimorphism in Lung Disease	7
Induced Pluripotent Stem Cell Technology: Trends in Molecular Biology, from Genetics to Epigenetics	6
Methylated ZNF582: a therapeutic target in oral cancer	6
Age-Related Changes in Sperm DNA Methylation and their Forensic and Clinical Implications	6
Promotional Effects of HIF1α and KDM3A Interaction on Vascular Smooth Muscle Cells in Thoracic Aortic Dissection	6
Epigenomics in the single cell era, an important read out for genome function and cell identity	6
NTRK Genes and Cancer: when Arresting the Fusion Underlies the Treatment	6
Phytochemicals in Cervical Cancer: An Epigenetic Overview	6
Epigenomic Impacts of Meditative Practices	6
The Ups and Downs of DNA Methylation: An Interview with Gerd Pfeifer	6
How do Sphingolipids Play a Role in Epigenetic Mechanisms and Gene Expression?	6
The Diagnostic Potential of the Epigenome in Autism Spectrum Disorders	6
Quantum Leap: Is the Conflux of Artificial Intelligence, Personalized Medicine, Nutrigenetics and Nutrigenomics the Path to Optimal Health?	6
The Epigenetic Impact of Adverse Childhood Experiences Through the Lens of Personalized Medicine	6
How does m ⁶ A Regulation Affect the Differentiation and Fate of Embryonic Stem Cells?	6
The Legacy Is Not Just With You: An Interview With Stephen Baylin	6
Early life trauma, DNA methylation and mental illness	6
Epigenetics and its Therapeutic Potential in Colorectal Cancer	6
Comprehensive Analysis of Epigenetic Modifications and Immune-Cell Infiltration In Tissues from Patients With Systemic Lupus Erythematosus	5
DNMT3a Promotes Osteoblast Differentiation and Alleviates Osteoporosis Via the PPARγ / SCD1 / GLUT1	5
Association of Grandmaternal Smoking During Pregnancy with DNA Methylation of Grandchildren: the Isle of Wight Study	5
Comparison of Methylation Episignatures in KMT2B - and KMT2D -Related Human Disorders	5
Value of CtDNA Methylation Biomarkers in Diagnosis of Colorectal Tumors	5
Epigenetic axis of SNHG19/miR-137/TNFAIP1 modulates amyloid beta peptide 25–35-induced SH-SY5Y cytotoxicity	5
The hMeDIP-Seq Identified INPP4A as a Novel Biomarker for Eosinophilic Chronic Rhinosinusitis with Nasal Polyps	5
Placental expression and methylation of angiogenic factors in assisted reproductive technology pregnancies from India	5
Neonatal necrotizing enterocolitis-associated DNA methylation signatures in the colon are evident in stool samples of affected individuals	5
Deep Characterization of Paired Chromatin and Transcriptomes in Four Immune Cell Types from Multiple Sclerosis Patients	5
Sex- and Tissue-Specific Effects of Binge-Level Prenatal Alcohol Consumption on DNA Methylation at Birth	5
Emergent properties of the lysine methylome reveal regulatory roles via protein interactions and histone mimicry	5
Genome-wide associations between alcohol consumption and blood DNA methylation: evidence from twin study	5
Epigenome-Wide Studies of Antipsychotics: A Systematic Review and Pathway Meta-Analysis	5
Identification of Histone Acetylation Modification Sites in the Striatum of Subchronically Manganese-Exposed Rats	5
tRNA-derived RNAs in human milk extracellular vesicles and associations with breastfeeding variables and maternal diet	5
Promoter hypermethylation of Y-chromosome gene PRKY as a potential biomarker for the early diagnosis of prostate cancer	5
Impact of prematurity on LINE-1 promoter methylation	5
Distinct Cytosine Modification Profiles Define Epithelial-to-MesenChymal Cell-State Transitions	5
How Epigenomics Broke the Mold: An Interview with Peter W Laird	5
Multi-omics insights into the pathogenesis of diabetic cardiomyopathy: epigenetic and metabolic profiles	5
NEAT1 Functions as a Key Mediator of BMP2 to promote osteogenic differentiation of renal interstitial fibroblasts	5
The Impact and Mechanism of TET3 Overexpression on the Progression of Hepatic Fibrosis	5
Alteration of DNA Methyltransferases by Eribulin Elicits Broad DNA Methylation Changes with Potential Therapeutic Implications for Triple-Negative Breast Cancer	5
Epigenetic rejuvenation: a journey backwards towards an epigenomic ground state	5