OOIR: Observatory of International Research

Papers

(The median citation count of IET Systems Biology is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Excavation of gene markers associated with pancreatic ductal adenocarcinoma based on interrelationships of gene expression	20
Identifying driver modules based on multi‐omics biological networks in prostate cancer	13
A comprehensive analysis of FBN2 in bladder cancer: A risk factor and the tumour microenvironment influencer	11
Novel Biomarker Identification for Acute Coronary Syndrome via Integrating WGCNA and Machine Learning	11
Transcriptome sequencing and metabolome analysis to reveal renewal evidence for drought adaptation in mulberry	11
Predictor‐Based Output Feedback Control of Tumour Growth With Positive Input: Application to Antiangiogenic Therapy	11
The Accuracy in Rupture Risk Prediction of Intracranial Aneurysms by Artificial Intelligence Algorithms Using Imaging Data From CTA and DSA: A Systematic Review and Meta‐Analysis	9
Functionalist Oncology to Model the Contextuality of Dynamics and Treatment in Acute Myeloid Leukaemia	9
High expression of centromere protein A and its molecular mechanism and clinical significance in prostate cancer: A study based on data mining and immunohistochemistry	8
Pan‐Cancer Integrative Analyses Reveal the Crosstalk Between the Intratumoral Microbiome, TP53 Mutation and Tumour Microenvironment	8
Transcriptome Analyses Reveal the Important miRNAs Involved in Immune Response of Gastric Cancer	8
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iGATTLDA: Integrative graph attention and transformer‐based model for predicting lncRNA‐Disease associations	7
Identification and analysis of epithelial‐mesenchymal transition‐related key long non‐coding RNAs in hypospadias	7
Identification of toll‐like receptor 5 and acyl‐CoA synthetase long chain family member 1 as hub genes are correlated with the severe forms of COVID‐19 by Weighted gene co‐expression network analysis	6
scGMB: A scRNA‐seq Cell Classification Method Combining GCN and Mamba	6
Integrative Analysis of Mitochondrial‐Related Genes Reveals Diagnostic Biomarkers and Therapeutic Targets in Acute Pancreatitis	6
Human essential gene identification based on feature fusion and feature screening	6
Robust positive control of tumour growth using angiogenic inhibition	5
MRANet: Multi‐Dimensional Residual Attentional Network for Precise Polyp Segmentation	5
Prediction and analysis of genetic effect in idiopathic pulmonary fibrosis and gastroesophageal reflux disease	5
MFS‐Unet: A Multi‐Path Vision Mamba Network for Precise Thyroid Nodule Segmentation	5
Fractional Order Total Variation Low‐Rank Representation on Single‐Cell RNA Sequencing Clustering	4
Identification of HIBCH and MGME1 as Mitochondrial Dynamics‐Related Biomarkers in Alzheimer's Disease Via Integrated Bioinformatics Analysis	4
Gut Microbiome and Paediatric Inflammatory Bowel Disease: Emerging Mechanistic and Therapeutic Insights Into Pathogenesis and Microbiota‐Based Approaches	4

Utilising Machine Learning and Single‐Cell Analysis to Uncover SKCM Metastasis–Related Genes	4
Continuous Cuffless Blood Pressure Estimation Based on Fractional Order Derivatives via Gramian Angular Field Only Using Photoplethysmograms	4
A Super‐Enhancer‐Related Ferroptosis Signature Predicts Survival and Immune Microenvironment in Colon Cancer Based on Bioinformatics Analyses and Experimental Validation	4
Co‐Expression Transcriptomic Profiling Identifies Sex‐Universal Molecular Markers of Muscle Atrophy	4
Cuproptosis‐related lncRNAs are correlated with tumour metabolism and immune microenvironment and predict prognosis in pancreatic cancer patients	3
Application of Fast Integration Strategy for Multi‐Omics Data and Limited Random Forest Model in Survival Prediction of Glioblastoma	3
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Comprehensive analysis of alternative splicing signatures in pancreatic head cancer	3
Machine learning unveils RNA polymerase II binding as a predictor for SMAD2‐dependent transcription dynamics in response to Actvin signalling	3
SpaGraphCCI: Spatial cell–cell communication inference through GAT‐based co‐convolutional feature integration	3
Identification of molecular subtypes of ischaemic stroke based on immune‐related genes and weighted co‐expression network analysis	3
Comprehensive analysis of LILR family genes expression and tumour‐infiltrating immune cells in early‐stage pancreatic ductal adenocarcinoma	3
PMLocMSCAM: Predicting miRNA Subcellular Localisations by miRNA Similarities and Cross‐Attention Mechanism	3
Genes associated with diagnosis and prognosis of Burkitt lymphoma	3
CAAFE‐ResNet: A ResNet With Channel Attention‐Augmented Feature Extraction for Prognostic Assessment in Rectal Cancer	3
Identification of an M1 Macrophages‐Related Signature for Predicting the Survival and Therapeutic Response in Gastric Cancer	3
A Neutrophil‐Based Predictive Model for Axillary De‐Escalation After Neoadjuvant Therapy in Node‐Positive Breast Cancer	2
Kinetic modelling of β ‐cell metabolism reveals control points in the insulin‐regulating pyruvate cycling pathways	2
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Adjusting laser power to control the heat generated by nanoparticles at the site of a patient's cells	2
CFMF: A Clustering‐Free Cell Marker Finder for Single‐Cell Transcriptomic Data	2
Mechanistic Investigation of Nitidine Chloride‐Mediated Anti‐Colorectal Cancer Activity: Centromere‐Associated Protein E Targeting via Integrated Molecular Dynamics, Spatial Transcriptomic and Single‐	2
An immune‐related multi‐omics analysis of dolichyl‐diphosphooligosaccharide protein glycosyltransferase in glioma: Prognostic value exploration and competitive endogenous RNA network identification	2
SeqBMC: Single‐cell data processing using iterative block matrix completion algorithm based on matrix factorisation	2
Investigating the Impact of Antibiotics on Environmental Microbiota Through Machine Learning Models	2
In silico analysis of the association between long non‐coding RNA family with sequence similarity 99 member A ( FAM99A ) and hepatic cancer	2
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Anoikis‐related genes as potential prognostic biomarkers in gastric cancer: A multilevel integrative analysis and predictive therapeutic value	2
The Potential Mechanism of Kushen Decoction in Treating Haemorrhoids: An Integration of Network Pharmacology, Molecular Docking and Molecular Dynamics Simulation	2
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Pan‐Cancer Analysis of CLDN3 and Its Contribution to 5‐FU Resistance in Colorectal Cancer	2
Hub genes and pathways in gastric cancer: A comparison between studies that used normal tissues adjacent to the tumour and studies that used healthy tissues as calibrator	2
Integration of Single‐Cell RNA and Bulk RNA Sequencing Reveals Cellular Heterogeneity and Identifies Survival‐Associated Regulatory Networks in Glioblastoma	2
PADG‐Pred: Exploring Ensemble Approaches for Identifying Parkinson's Disease Associated Biomarkers Using Genomic Sequences Analysis	2
ACP‐DPE: A Dual‐Channel Deep Learning Model for Anticancer Peptide Prediction	2
Cascade Aggregation Network for Accurate Polyp Segmentation	2
StackAHTPs: An explainable antihypertensive peptides identifier based on heterogeneous features and stacked learning approach	2
Gene signatures of endoplasmic reticulum stress and mitophagy for prognostic risk prediction in lung adenocarcinoma	2
DNA methylation plays important roles in lifestyle transition of Arthrobotrys oligospora	2
Integrated bioinformatics analysis identified leucine rich repeat containing 15 and secreted phosphoprotein 1 as hub genes for calcific aortic valve disease and osteoarthritis	2
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Characterising and Evaluating the Immune Microenvironment Landscapes of Colorectal Cancer Shaped by Different Therapies	1
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The effect of normalisation and error model choice on the distribution of the maximum likelihood estimator for a biochemical reaction	1
Integrative Machine Learning and Bioinformatics Approach for Identifying Key Biomarkers in Gallbladder Cancer Diagnosis and Progression	1
Bioinformatics approach to identify the hub gene associated with COVID‐19 and idiopathic pulmonary fibrosis	1
Metabolic Reprogramming in Recurrent Spontaneous Abortion: Key Biomarkers Identification and Diagnostic Model Development	1
Deep‐GB: A novel deep learning model for globular protein prediction using CNN‐BiLSTM architecture and enhanced PSSM with trisection strategy	1
Proteins Combined Score Prediction Based on Improved Gene Expression Programming Algorithm and Protein–Protein Interaction Network Characterization	1

Machine Learning‐Based Integrative Analysis Identifies SUMOylation‐Related Genes Underlying the Immune Heterogeneity of Sepsis	1
Research on symptoms composition, time series evolution, and network visualisation of interstitial cystitis based on complex network community discovery algorithm	1
Inference and analysis of cell‐cell communication of non‐myeloid circulating cells in late sepsis based on single‐cell RNA‐seq	1
Microbiome analysis reveals the potential mechanism of herbal sitz bath complementary therapy in accelerating postoperative recovery from perianal abscesses	1
Deep Learning Can Predict the Overall Survival of Cervical Cancer Based on Histopathological Image, Gene Mutation and Clinical Information	1
Gut Microbiota Mediate Periampullary Cancer Through Extracellular Matrix Proteins: A Causal Relationship Study	1
The ‘Other’ subfamily of HECT E3 ubiquitin ligases evaluate the tumour immune microenvironment and prognosis in patients with hepatocellular carcinoma	1
Identification of CCR7 and CBX6 as key biomarkers in abdominal aortic aneurysm: Insights from multi‐omics data and machine learning analysis	1
scRSSL: Residual semi‐supervised learning with deep generative models to automatically identify cell types	1
Comprehensive transcriptome and scRNA‐seq analyses uncover the expression and underlying mechanism of SYNJ2 in papillary thyroid carcinoma	1
siRNAEfficacyDB: An experimentally supported small interfering RNA efficacy database	1
Multi‐Omics Analysis and Experimental Validation Identify RAD51 as a Key Biomarker in OSCC	1
MFR‐UNet: A Medical Image Segmentation Network With Fused Multi‐Scale Feature Refinement	1
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