OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Biological Engineering is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Advanced metabolic Engineering strategies for the sustainable production of free fatty acids and their derivatives using yeast	228
Droplet microfluidic screening to engineer angiotensin-converting enzyme 2 (ACE2) catalytic activity	102
Gene syntaxes modulate gene expression and circuit behavior on plasmids	80
Cerium-doped calcium carbonate microparticles combined with low-intensity ultrasound for efficient sonodynamic therapy in body sculpting	69
Promoting osteogenesis and bone regeneration employing icariin-loaded nanoplatforms	61
Osteogenic differentiation of adipose-derived stem cells on dihydroartemisinin electrospun nanofibers	53
3D-printed PCL@BG scaffold integrated with SDF-1α-loaded hydrogel for enhancing local treatment of bone defects	49
Tissue engineering of the gastrointestinal tract: the historic path to translation	38
A new approach to off-gas analysis for shaken bioreactors showing high CTR and RQ accuracy	35
Engineered hypoxia-responding Escherichia coli carrying cardiac peptide genes, suppresses tumor growth, angiogenesis and metastasis in vivo	34
3D-printed nanohydroxyapatite/methylacrylylated silk fibroin scaffold for repairing rat skull defects	31
Core-shell nanofiber dressings with zinc oxide nanoparticles and cell-free fat extract: boosting fibroblast activity and antibacterial efficacy	27
Cell-cultivated aquatic food products: emerging production systems for seafood	27
Research progress of biomimetic materials in oral medicine	26
A CRISPR interference strategy for gene expression silencing in multiple myeloma cell lines	25
Role of mesenchymal stem cell-derived exosomes in the regeneration of different tissues	25
Tissue engineering in age-related macular degeneration: a mini-review	24
RN-Autoencoder: Reduced Noise Autoencoder for classifying imbalanced cancer genomic data	23
Quantitative imaging of magnetic nanoparticles in an unshielded environment using a large AC susceptibility array	23
Codeine 3-O-demethylase catalyzed biotransformation of morphinan alkaloids in Escherichia coli: site directed mutagenesis of terminal residues improves enzyme expression, stability and biotransformati	23
Bio-engineered thermo-sensitive alginate/PNIA-g-CS co-polymeric injectable hydrogel laden with GDF-5 to stimulate nucleus pulposus for IVD regeneration	22
Influence of shear force on ex vivo expansion of hematopoietic model cells in a stirred tank bioreactor	21
Enhancing chemical and physical stability of pharmaceuticals using freeze-thaw method: challenges and opportunities for process optimization through quality by design approach	18
Nonthermal biocompatible plasma in stimulating osteogenic differentiation by targeting p38/ FOXO1 and PI3K/AKT pathways in hBMSCs	17
Rapid osteoinduction of human adipose-derived stem cells grown on bioactive surfaces and stimulated by chemically modified media flow	17

DC electrical stimulation enhances proliferation and differentiation on N2a and MC3T3 cell lines	17
Automated classification of urine biomarkers to diagnose pancreatic cancer using 1-D convolutional neural networks	17
Fabricating a robust POSS-PCL nanofiber scaffold for nesting of mesenchymal stem cells: potential application in bone tissue regeneration	16
Chitosan modified with PAP as a promising delivery system for melatonin in the treatment of osteoporosis: targeting the divalent metal transporter 1	16
The use of a novel deer antler decellularized cartilage-derived matrix scaffold for repair of osteochondral defects	15
An in vitro culture platform for studying the effect of collective cell migration on spatial self-organization within induced pluripotent stem cell colonies	15
High-throughput proliferation and activation of NK-92MI cell spheroids via a homemade one-step closed bioreactor in pseudostatic cultures for immunocellular therapy	14
The lyophilized chloroplasts store synthetic DARPin G3 as bioactive encapsulated organelles	14
Identification and verification of diagnostic biomarkers for deep infiltrating endometriosis based on machine learning algorithms	13
Role of viscoelasticity in the appearance of low-Reynolds turbulence: considerations for modelling	13
Unraveling pathogenesis, biomarkers and potential therapeutic agents for endometriosis associated with disulfidptosis based on bioinformatics analysis, machine learning and experiment validation	13
Rapid remodeling observed at mid-term in-vivo study of a smart reinforced acellular vascular graft implanted on a rat model	13
Optimization of a recombinant BlaR-CTD protein formulation using the response surface methodology	12
Microfluidic chip and isothermal amplification technologies for the detection of pathogenic nucleic acid	12
Tissue engineering RPE sheet derived from hiPSC-RPE cell spheroids supplemented with Y-27632 and RepSox	12
Application of decellularized bone matrix as a bioscaffold in bone tissue engineering	12
CRISPRi-assisted metabolic engineering of cyanobacteria for photosynthetic hyaluronic acid from CO2	11
Clinical utility of mesenchymal stem/stromal cells in regenerative medicine and cellular therapy	11
Customized biofilm device for antibiofilm and antibacterial screening of newly developed nanostructured silver and zinc coatings	11
Dual-responsive synthetic gene circuit for dynamic biologic drug delivery via inflammatory and circadian signaling pathways	11
Biomaterial-based chitosan nanohydrogel films: combination of Bistorta officinalis and Ca-doped carbon dots for improved blood clotting	11
Early introduction of 3D modeling modules promotes the development of simulation skills in downstream biomedical engineering curricula	11
Eggshell waste bioprocessing for sustainable acid phosphatase production and minimizing environmental hazards	11
Potential application of hydrogel to the diagnosis and treatment of multiple sclerosis	11
Structural insights into inhibition of PRRSV Nsp4 revealed by structure-based virtual screening, molecular dynamics, and MM-PBSA studies	11
Fetal ischemia monitoring with in vivo implanted electrochemical multiparametric microsensors	11
Genetically engineered secretory horseradish peroxidase is a sensitive, stable, and affordable non-lytic reporter gene system for real-time promoter activity management	11
Fluorescent tools for the standardized work in Gram-negative bacteria	10
Cloning, expression, and one-step purification/immobilization of two carbohydrate-binding module-tagged alcohol dehydrogenases	10
Engineering probiotic Escherichia coli for inflammation-responsive indoleacetic acid production using RiboJ-enhanced genetic circuits	10
Review: biological engineering for nature-based climate solutions	10
Microfluidic device for enhancement and analysis of osteoblast differentiation in three-dimensional cell cultures	10
NIR-activated catechol-functionalized nanodiamond nanofibers for accelerating on-demand MRSA and E. coli biofilm eradication	10
Correction: Engineered hypoxia-responding Escherichia coli carrying cardiac peptide genes, suppresses tumor growth, angiogenesis and metastasis in vivo	10
Codon usage modulates the relationship between the burden and yield of protein overexpression	10
Enhancing bioprocessing of red pigment from immobilized culture of gamma rays mutant of the endophytic fungus Monascus ruber SRZ112	9
Phytoconstituents of Withania somnifera (L.) Dunal (Ashwagandha) unveiled potential cerebroside sulfotransferase inhibitors: insight through virtual screening, molecular dynamics, toxicity, and revers	9
A novel inductively coupled capacitor wireless sensor system for rapid antibiotic susceptibility testing	9
Applications of carbon dots and its modified carbon dots in bone defect repair	9
Seaweed-based alginate/hydroxyapatite composite for the effective removal of bacteria, cyanobacteria, algae, and crystal violet from water	9