OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Biological Engineering is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Nano-size tantalum particles suppress the osteogenic activity of osteoblasts and stimulate osteoclasts	297
Cerium-doped calcium carbonate microparticles combined with low-intensity ultrasound for efficient sonodynamic therapy in body sculpting	125
Droplet microfluidic screening to engineer angiotensin-converting enzyme 2 (ACE2) catalytic activity	100
Advanced metabolic Engineering strategies for the sustainable production of free fatty acids and their derivatives using yeast	99
Self-healing PVA/PVP micelle–hydrogel composite system for potential phenytoin repositioning in wound healing	83
Gene syntaxes modulate gene expression and circuit behavior on plasmids	74
Promoting osteogenesis and bone regeneration employing icariin-loaded nanoplatforms	71
Combinatorial engineering pinpoints shikimate pathway bottlenecks in para-aminobenzoic acid production in Pseudomonas putida	56
Osteogenic differentiation of adipose-derived stem cells on dihydroartemisinin electrospun nanofibers	52
New approach methodologies for in vitro toxicity screening of nanomaterial using a pulmonary three-dimensional floating extracellular matrix model	46
Integrated genomic and transcriptomic Insights into methanol tolerance mechanisms in Methylobacterium extorquens AM1, identifying key targets for strain engineering	45
Core-shell nanofiber dressings with zinc oxide nanoparticles and cell-free fat extract: boosting fibroblast activity and antibacterial efficacy	44
Role of mesenchymal stem cell-derived exosomes in the regeneration of different tissues	44
Research progress of biomimetic materials in oral medicine	42
A new approach to off-gas analysis for shaken bioreactors showing high CTR and RQ accuracy	41
3D-printed PCL@BG scaffold integrated with SDF-1α-loaded hydrogel for enhancing local treatment of bone defects	36
Cell-cultivated aquatic food products: emerging production systems for seafood	35
Tissue engineering of the gastrointestinal tract: the historic path to translation	33
Codeine 3-O-demethylase catalyzed biotransformation of morphinan alkaloids in Escherichia coli: site directed mutagenesis of terminal residues improves enzyme expression, stability and biotransformati	32
3D-printed nanohydroxyapatite/methylacrylylated silk fibroin scaffold for repairing rat skull defects	32
Automated classification of urine biomarkers to diagnose pancreatic cancer using 1-D convolutional neural networks	31
Integration of TLR7/8 agonists into lipid nanoparticles enhances antigen-specific immune responses to N1-methyl-Ψ-modified mRNA-LNP vaccines	31
Quantitative imaging of magnetic nanoparticles in an unshielded environment using a large AC susceptibility array	31
A CRISPR interference strategy for gene expression silencing in multiple myeloma cell lines	31
RN-Autoencoder: Reduced Noise Autoencoder for classifying imbalanced cancer genomic data	25

Bio-engineered thermo-sensitive alginate/PNIA-g-CS co-polymeric injectable hydrogel laden with GDF-5 to stimulate nucleus pulposus for IVD regeneration	24
Influence of shear force on ex vivo expansion of hematopoietic model cells in a stirred tank bioreactor	22
Tissue engineering in age-related macular degeneration: a mini-review	22
Enhancing chemical and physical stability of pharmaceuticals using freeze-thaw method: challenges and opportunities for process optimization through quality by design approach	21
Exploring of therapeutic potential of indirubin-loaded nanofibrous scaffolds for localized melanoma treatment	20
Efficient site-specific recombination by self-activating split-Dre recombinase in mammalian cells and E. coli	20
Nonthermal biocompatible plasma in stimulating osteogenic differentiation by targeting p38/ FOXO1 and PI3K/AKT pathways in hBMSCs	19
Chitosan modified with PAP as a promising delivery system for melatonin in the treatment of osteoporosis: targeting the divalent metal transporter 1	19
DC electrical stimulation enhances proliferation and differentiation on N2a and MC3T3 cell lines	19
Rapid osteoinduction of human adipose-derived stem cells grown on bioactive surfaces and stimulated by chemically modified media flow	18
Harnessing plant chloroplasts for oral delivery of a multi-epitope HPV vaccine: toward cost-effective systemic and mucosal immunization	18
Fabricating a robust POSS-PCL nanofiber scaffold for nesting of mesenchymal stem cells: potential application in bone tissue regeneration	18
Biology-inspired engineering for circular bioeconomy systems	17
An in vitro culture platform for studying the effect of collective cell migration on spatial self-organization within induced pluripotent stem cell colonies	17
Unraveling pathogenesis, biomarkers and potential therapeutic agents for endometriosis associated with disulfidptosis based on bioinformatics analysis, machine learning and experiment validation	17
Design and performance analysis of bionic trabecular bone scaffold structure based on Voronoi	17
Identification and verification of diagnostic biomarkers for deep infiltrating endometriosis based on machine learning algorithms	17
High-throughput proliferation and activation of NK-92MI cell spheroids via a homemade one-step closed bioreactor in pseudostatic cultures for immunocellular therapy	16
The lyophilized chloroplasts store synthetic DARPin G3 as bioactive encapsulated organelles	16
Rapid remodeling observed at mid-term in-vivo study of a smart reinforced acellular vascular graft implanted on a rat model	16
Application of decellularized bone matrix as a bioscaffold in bone tissue engineering	16
Tissue engineering RPE sheet derived from hiPSC-RPE cell spheroids supplemented with Y-27632 and RepSox	15
Role of viscoelasticity in the appearance of low-Reynolds turbulence: considerations for modelling	15
Microfluidic chip and isothermal amplification technologies for the detection of pathogenic nucleic acid	15
Biomaterials for fetal membrane repair in preterm premature rupture of membranes: advances in tissue engineering strategies	14
Optimization of a recombinant BlaR-CTD protein formulation using the response surface methodology	14
CRISPRi-assisted metabolic engineering of cyanobacteria for photosynthetic hyaluronic acid from CO2	14
Clinical utility of mesenchymal stem/stromal cells in regenerative medicine and cellular therapy	14
Biomaterial-based chitosan nanohydrogel films: combination of Bistorta officinalis and Ca-doped carbon dots for improved blood clotting	14
Structural insights into inhibition of PRRSV Nsp4 revealed by structure-based virtual screening, molecular dynamics, and MM-PBSA studies	14
Effect of recombinant protein production and release on microalgal fitness and the impact of environmental conditions for localized therapeutic delivery	14
Cloning, expression, and one-step purification/immobilization of two carbohydrate-binding module-tagged alcohol dehydrogenases	13
Early introduction of 3D modeling modules promotes the development of simulation skills in downstream biomedical engineering curricula	13
Efflux pump knockout minimizes crosstalk and boosts response in transcription factor-based biosensors	13
Genetically engineered secretory horseradish peroxidase is a sensitive, stable, and affordable non-lytic reporter gene system for real-time promoter activity management	13
Quantitative impedance-based characterization of breast cancer cell migration and metastatic potential	13
Potential application of hydrogel to the diagnosis and treatment of multiple sclerosis	12
Codon usage modulates the relationship between the burden and yield of protein overexpression	12
Dual-responsive synthetic gene circuit for dynamic biologic drug delivery via inflammatory and circadian signaling pathways	12
Customized biofilm device for antibiofilm and antibacterial screening of newly developed nanostructured silver and zinc coatings	12
Eggshell waste bioprocessing for sustainable acid phosphatase production and minimizing environmental hazards	12
Microfluidic device for enhancement and analysis of osteoblast differentiation in three-dimensional cell cultures	12
Applications of carbon dots and its modified carbon dots in bone defect repair	11
Enhanced methanol tolerance and utilization in Pichia pastoris revealed by adaptive laboratory evolution	11
Fluorescent tools for the standardized work in Gram-negative bacteria	11
Correction: Engineered hypoxia-responding Escherichia coli carrying cardiac peptide genes, suppresses tumor growth, angiogenesis and metastasis in vivo	11
Engineering probiotic Escherichia coli for inflammation-responsive indoleacetic acid production using RiboJ-enhanced genetic circuits	11
Review: biological engineering for nature-based climate solutions	11
Seaweed-based alginate/hydroxyapatite composite for the effective removal of bacteria, cyanobacteria, algae, and crystal violet from water	10
Enhancing osteogenic differentiation of dental pulp stem cells through rosuvastatin loaded niosomes optimized by Box-Behnken design and modified by hyaluronan: a novel strategy for improved efficiency	10

NIR-activated catechol-functionalized nanodiamond nanofibers for accelerating on-demand MRSA and E. coli biofilm eradication	10
Combined drugs-loaded nano-lipodisk carrier for pH-responsive delivery for improved therapeutic potential on lung cancer model	10
3D printed zirconia used as dental materials: a critical review	10
A novel inductively coupled capacitor wireless sensor system for rapid antibiotic susceptibility testing	10
Exosome-functionalized collagen-coated 3D-printed PCL scaffold for enhanced osteogenic differentiation and bone regeneration: an in vitro and in vivo study	10
Anti-inflammatory activity of magnetic fields emitted by graphene devices on cultured human cells	9
Phytoconstituents of Withania somnifera (L.) Dunal (Ashwagandha) unveiled potential cerebroside sulfotransferase inhibitors: insight through virtual screening, molecular dynamics, toxicity, and revers	9
Optimizing the fabrication of a 3D high-resolution implant for neural stimulation	9
Correction to: Challenges and progress of neurodrug: bioactivities, production and delivery strategies of nerve growth factor protein	9
Light scattering-based screening method for rapid evaluating antibiotic effects on bacteria using laser speckle imaging	9
Chitosan as a promising materials for the construction of nanocarriers for diabetic retinopathy: an updated review	9
Bilayer osteochondral graft in rabbit xenogeneic transplantation model comprising sintered 3D-printed bioceramic and human adipose-derived stem cells laden biohydrogel	9
Construction of bispecific antibodies by specific pairing between the heavy chain and the light chain using removable SpyCatcher/SnoopCatcher units	9
Enhancing bioprocessing of red pigment from immobilized culture of gamma rays mutant of the endophytic fungus Monascus ruber SRZ112	9
Correction: Follicular reconstruction and neo-oogenesis in xenotransplantation of human ovarian isolated cells derived from chemotherapy-induced POF patients	9
Enhancing in vitro osteogenic differentiation of mesenchymal stem cells via sustained dexamethasone delivery in 3D-Printed hybrid scaffolds based on polycaprolactone-nanohydroxyapatite/alginate-gelati	9
A dual-inducible control system for multistep biosynthetic pathways	9
Insect cell expression system: advances in applications, engineering strategies, and bioprocess development	9