OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Biological Engineering is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Droplet microfluidic screening to engineer angiotensin-converting enzyme 2 (ACE2) catalytic activity	278
Gene syntaxes modulate gene expression and circuit behavior on plasmids	117
Cerium-doped calcium carbonate microparticles combined with low-intensity ultrasound for efficient sonodynamic therapy in body sculpting	91
Promoting osteogenesis and bone regeneration employing icariin-loaded nanoplatforms	88
Advanced metabolic Engineering strategies for the sustainable production of free fatty acids and their derivatives using yeast	81
Nano-size tantalum particles suppress the osteogenic activity of osteoblasts and stimulate osteoclasts	68
New approach methodologies for in vitro toxicity screening of nanomaterial using a pulmonary three-dimensional floating extracellular matrix model	63
Combinatorial engineering pinpoints shikimate pathway bottlenecks in para-aminobenzoic acid production in Pseudomonas putida	50
Role of mesenchymal stem cell-derived exosomes in the regeneration of different tissues	49
Cell-cultivated aquatic food products: emerging production systems for seafood	42
Osteogenic differentiation of adipose-derived stem cells on dihydroartemisinin electrospun nanofibers	41
3D-printed nanohydroxyapatite/methylacrylylated silk fibroin scaffold for repairing rat skull defects	41
Research progress of biomimetic materials in oral medicine	40
3D-printed PCL@BG scaffold integrated with SDF-1α-loaded hydrogel for enhancing local treatment of bone defects	36
A new approach to off-gas analysis for shaken bioreactors showing high CTR and RQ accuracy	32
Tissue engineering of the gastrointestinal tract: the historic path to translation	31
A CRISPR interference strategy for gene expression silencing in multiple myeloma cell lines	30
Codeine 3-O-demethylase catalyzed biotransformation of morphinan alkaloids in Escherichia coli: site directed mutagenesis of terminal residues improves enzyme expression, stability and biotransformati	30
Core-shell nanofiber dressings with zinc oxide nanoparticles and cell-free fat extract: boosting fibroblast activity and antibacterial efficacy	30
Tissue engineering in age-related macular degeneration: a mini-review	29
Quantitative imaging of magnetic nanoparticles in an unshielded environment using a large AC susceptibility array	28
Bio-engineered thermo-sensitive alginate/PNIA-g-CS co-polymeric injectable hydrogel laden with GDF-5 to stimulate nucleus pulposus for IVD regeneration	27
Automated classification of urine biomarkers to diagnose pancreatic cancer using 1-D convolutional neural networks	26
Enhancing chemical and physical stability of pharmaceuticals using freeze-thaw method: challenges and opportunities for process optimization through quality by design approach	25
Influence of shear force on ex vivo expansion of hematopoietic model cells in a stirred tank bioreactor	24

RN-Autoencoder: Reduced Noise Autoencoder for classifying imbalanced cancer genomic data	24
Rapid osteoinduction of human adipose-derived stem cells grown on bioactive surfaces and stimulated by chemically modified media flow	22
Fabricating a robust POSS-PCL nanofiber scaffold for nesting of mesenchymal stem cells: potential application in bone tissue regeneration	20
Chitosan modified with PAP as a promising delivery system for melatonin in the treatment of osteoporosis: targeting the divalent metal transporter 1	19
Efficient site-specific recombination by self-activating split-Dre recombinase in mammalian cells and E. coli	18
DC electrical stimulation enhances proliferation and differentiation on N2a and MC3T3 cell lines	17
Nonthermal biocompatible plasma in stimulating osteogenic differentiation by targeting p38/ FOXO1 and PI3K/AKT pathways in hBMSCs	17
High-throughput proliferation and activation of NK-92MI cell spheroids via a homemade one-step closed bioreactor in pseudostatic cultures for immunocellular therapy	17
The lyophilized chloroplasts store synthetic DARPin G3 as bioactive encapsulated organelles	16
An in vitro culture platform for studying the effect of collective cell migration on spatial self-organization within induced pluripotent stem cell colonies	16
Biology-inspired engineering for circular bioeconomy systems	16
Application of decellularized bone matrix as a bioscaffold in bone tissue engineering	16
Unraveling pathogenesis, biomarkers and potential therapeutic agents for endometriosis associated with disulfidptosis based on bioinformatics analysis, machine learning and experiment validation	16
Identification and verification of diagnostic biomarkers for deep infiltrating endometriosis based on machine learning algorithms	16
Rapid remodeling observed at mid-term in-vivo study of a smart reinforced acellular vascular graft implanted on a rat model	15
Role of viscoelasticity in the appearance of low-Reynolds turbulence: considerations for modelling	15
Microfluidic chip and isothermal amplification technologies for the detection of pathogenic nucleic acid	15
Tissue engineering RPE sheet derived from hiPSC-RPE cell spheroids supplemented with Y-27632 and RepSox	14
Optimization of a recombinant BlaR-CTD protein formulation using the response surface methodology	14
Structural insights into inhibition of PRRSV Nsp4 revealed by structure-based virtual screening, molecular dynamics, and MM-PBSA studies	13
Fetal ischemia monitoring with in vivo implanted electrochemical multiparametric microsensors	13
Biomaterial-based chitosan nanohydrogel films: combination of Bistorta officinalis and Ca-doped carbon dots for improved blood clotting	13
Early introduction of 3D modeling modules promotes the development of simulation skills in downstream biomedical engineering curricula	13
CRISPRi-assisted metabolic engineering of cyanobacteria for photosynthetic hyaluronic acid from CO2	13
Effect of recombinant protein production and release on microalgal fitness and the impact of environmental conditions for localized therapeutic delivery	13
Clinical utility of mesenchymal stem/stromal cells in regenerative medicine and cellular therapy	13
Eggshell waste bioprocessing for sustainable acid phosphatase production and minimizing environmental hazards	12
Codon usage modulates the relationship between the burden and yield of protein overexpression	12
Microfluidic device for enhancement and analysis of osteoblast differentiation in three-dimensional cell cultures	12
Genetically engineered secretory horseradish peroxidase is a sensitive, stable, and affordable non-lytic reporter gene system for real-time promoter activity management	12
Potential application of hydrogel to the diagnosis and treatment of multiple sclerosis	12
Dual-responsive synthetic gene circuit for dynamic biologic drug delivery via inflammatory and circadian signaling pathways	12
NIR-activated catechol-functionalized nanodiamond nanofibers for accelerating on-demand MRSA and E. coli biofilm eradication	11
Correction: Engineered hypoxia-responding Escherichia coli carrying cardiac peptide genes, suppresses tumor growth, angiogenesis and metastasis in vivo	11
Quantitative impedance-based characterization of breast cancer cell migration and metastatic potential	11
Engineering probiotic Escherichia coli for inflammation-responsive indoleacetic acid production using RiboJ-enhanced genetic circuits	11
Customized biofilm device for antibiofilm and antibacterial screening of newly developed nanostructured silver and zinc coatings	11
Review: biological engineering for nature-based climate solutions	11
Fluorescent tools for the standardized work in Gram-negative bacteria	11
Cloning, expression, and one-step purification/immobilization of two carbohydrate-binding module-tagged alcohol dehydrogenases	11
Enhancing osteogenic differentiation of dental pulp stem cells through rosuvastatin loaded niosomes optimized by Box-Behnken design and modified by hyaluronan: a novel strategy for improved efficiency	10
Seaweed-based alginate/hydroxyapatite composite for the effective removal of bacteria, cyanobacteria, algae, and crystal violet from water	10
A novel inductively coupled capacitor wireless sensor system for rapid antibiotic susceptibility testing	10
Applications of carbon dots and its modified carbon dots in bone defect repair	10
Bilayer osteochondral graft in rabbit xenogeneic transplantation model comprising sintered 3D-printed bioceramic and human adipose-derived stem cells laden biohydrogel	10
Phytoconstituents of Withania somnifera (L.) Dunal (Ashwagandha) unveiled potential cerebroside sulfotransferase inhibitors: insight through virtual screening, molecular dynamics, toxicity, and revers	10
Correction to: Challenges and progress of neurodrug: bioactivities, production and delivery strategies of nerve growth factor protein	10
3D printed zirconia used as dental materials: a critical review	9
Anti-inflammatory activity of magnetic fields emitted by graphene devices on cultured human cells	9
Optimizing the fabrication of a 3D high-resolution implant for neural stimulation	9

Enhancing in vitro osteogenic differentiation of mesenchymal stem cells via sustained dexamethasone delivery in 3D-Printed hybrid scaffolds based on polycaprolactone-nanohydroxyapatite/alginate-gelati	9
Enhancing bioprocessing of red pigment from immobilized culture of gamma rays mutant of the endophytic fungus Monascus ruber SRZ112	9
Correction: Follicular reconstruction and neo-oogenesis in xenotransplantation of human ovarian isolated cells derived from chemotherapy-induced POF patients	9
Construction of bispecific antibodies by specific pairing between the heavy chain and the light chain using removable SpyCatcher/SnoopCatcher units	9
A dual-inducible control system for multistep biosynthetic pathways	9
Light scattering-based screening method for rapid evaluating antibiotic effects on bacteria using laser speckle imaging	9
Chitosan as a promising materials for the construction of nanocarriers for diabetic retinopathy: an updated review	9
Engineering the T6SS of Pseudomonas for targeted delivery of antibacterial and antifungal effectors	9