OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Protocols is 68. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Author Correction: Z-REX: shepherding reactive electrophiles to specific proteins expressed tissue specifically or ubiquitously, and recording the resultant functional electrophile-induced redox respo	1046
Author Correction: cfSNV: a software tool for the sensitive detection of somatic mutations from cell-free DNA	493
Cytosine and adenosine base editing in human pluripotent stem cells using transient reporters for editing enrichment	457
Open thoracic surgical implantation of cardiac pacemakers in rats	360
Open-vessel polymerization of N-carboxyanhydride (NCA) for polypeptide synthesis	358
Purification and functional characterization of novel human skeletal stem cell lineages	332
Design and application of the transformer base editor in mammalian cells and mice	284
Generation of heart-forming organoids from human pluripotent stem cells	276
Isoform-specific RNA structure determination using Nano-DMS-MaP	238
ChromEMT: visualizing and reconstructing chromatin ultrastructure and 3D organization in situ	235
Routine culture and study of adult human brain cells from neurosurgical specimens	218
Analysis of combinatorial CRISPR screens with the Orthrus scoring pipeline	204
Generating human bone marrow organoids for disease modeling and drug discovery	202
GLORI for absolute quantification of transcriptome-wide m6A at single-base resolution	196
Reproducible strategy for excisional skin-wound-healing studies in mice	194
Visualization of metabolites and microbes at high spatial resolution using MALDI mass spectrometry imaging and in situ fluorescence labeling	188
Three-dimensional human neural culture on a chip recapitulating neuroinflammation and neurodegeneration	186
Photoimmunotechnology as a powerful biological tool for molecular-based elimination of target cells and microbes, including bacteria, fungi and viruses	183
Author Correction: Reliable detection of somatic mutations in solid tissues by laser-capture microdissection and low-input DNA sequencing	168
Head-mounted central venous access during optical recordings and manipulations of neural activity in mice	167
Author Correction: Chromatin integration labeling for mapping DNA-binding proteins and modifications with low input	165
Publisher Correction: Rapid reaction optimization by robust and economical quantitative benchtop 19F NMR spectroscopy	152
Rapid reaction optimization by robust and economical quantitative benchtop 19F NMR spectroscopy	152
How to isolate channel-forming membrane proteins using the E. coli expression system	150
Publisher Correction: In vivo pulse labeling of isochronic cohorts of cells in the central nervous system using FlashTag	140

Fabrication of thin-film electrodes and organic electrochemical transistors for neural implants	140
Precise tracking of nanoparticles in plant roots	137
Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells	134
High-throughput fabrication of antimicrobial phage microgels and example applications in food decontamination	134
Chromatin accessibility profiling by ATAC-seq	132
Implantation of Neuropixels probes for chronic recording of neuronal activity in freely behaving mice and rats	123
Small RNA structural biochemistry in a post-sequencing era	122
Spatially resolved epigenome sequencing via Tn5 transposition and deterministic DNA barcoding in tissue	120
Tutorial: using nanoneedles for intracellular delivery	120
Quantitative molecular imaging using deep magnetic resonance fingerprinting	118
Stable isotope tracing to assess tumor metabolism in vivo	117
Fabrication of electron tunneling probes for measuring single-protein conductance	113
SubCellBarCode: integrated workflow for robust spatial proteomics by mass spectrometry	111
Hyperosmolar blood–brain barrier opening using intra-arterial injection of hyperosmotic mannitol in mice under real-time MRI guidance	110
Bioengineering human intestinal mucosal grafts using patient-derived organoids, fibroblasts and scaffolds	106
Sequential orthogonal assays for longitudinal and endpoint characterization of three-dimensional spheroids	106
Achieving transient and reversible optical transparency in live mice with tartrazine	101
Gene expression and chromatin state mapped in space	97
Collections from Nature Protocols	96
A versatile tissue-rolling technique for spatial-omics analyses of the entire murine gastrointestinal tract	91
Establishment of human induced trophoblast stem cells via reprogramming of fibroblasts	91
Unraveling cell–cell communication with NicheNet by inferring active ligands from transcriptomics data	91
Honey bee functional genomics using symbiont-mediated RNAi	89
mRNA lipid nanoparticle formulation, characterization and evaluation	89
Large-scale growth of C. elegans and isolation of membrane protein complexes	88
Generation and long-term culture of human cerebellar organoids from pluripotent stem cells	87
Structural connectome construction using constrained spherical deconvolution in multi-shell diffusion-weighted magnetic resonance imaging	86
Controlling the polarity of human gastrointestinal organoids to investigate epithelial biology and infectious diseases	86
Generation of iPSC-derived human forebrain organoids assembling bilateral eye primordia	86
Mitochondrial single-cell ATAC-seq for high-throughput multi-omic detection of mitochondrial genotypes and chromatin accessibility	83
A ‘print–pause–print’ protocol for 3D printing microfluidics using multimaterial stereolithography	82
Preparation and quantitative analysis of multicenter luminescence materials for sensing function	80
Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery	79
Comprehensive synthesis of Ti3C2Tx from MAX phase to MXene	79
Fibrous polyisocyanide hydrogels for 3D cell culture applications	79
Publisher Correction: A reconstituted cell-free assay for the evaluation of the intrinsic activity of purified human ribosomes	77
Author Correction: Efficient and strand-specific profiling of replicating chromatin with enrichment and sequencing of protein-associated nascent DNA in mammalian cells	72
Plant sperm cell sequencing for genome phasing and determination of meiotic crossover points	71
Inverse electron demand Diels–Alder click chemistry for pretargeted PET imaging and radioimmunotherapy	71
A bifunctional molecule-assisted synthesis of mimics for use in probing the ubiquitination system	68
Genome-wide quantification of transcription factor binding at single-DNA-molecule resolution using methyl-transferase footprinting	68
Divergent synthesis of amino acid-linked O-GalNAc glycan core structures	68
Integrating genome-wide CRISPR screens and in silico drug profiling for targeted antidote development	68