OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Protocols is 65. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Inducible CRISPR–Cas9 screening platform to interrogate non-proliferative cellular states	1284
Open thoracic surgical implantation of cardiac pacemakers in rats	1051
Design and application of the transformer base editor in mammalian cells and mice	871
Automated cGMP optical labeling of FDA-approved antibodies for human use	662
Author Correction: Z-REX: shepherding reactive electrophiles to specific proteins expressed tissue specifically or ubiquitously, and recording the resultant functional electrophile-induced redox respo	474
Author Correction: cfSNV: a software tool for the sensitive detection of somatic mutations from cell-free DNA	470
Open-vessel polymerization of N-carboxyanhydride (NCA) for polypeptide synthesis	458
GLORI for absolute quantification of transcriptome-wide m6A at single-base resolution	314
Reproducible strategy for excisional skin-wound-healing studies in mice	299
Visualization of metabolites and microbes at high spatial resolution using MALDI mass spectrometry imaging and in situ fluorescence labeling	296
Generating human bone marrow organoids for disease modeling and drug discovery	248
GPSeq maps the radial organization of eukaryotic genomes along the nuclear periphery–center axis	241
Patient-derived ependymoma and medulloblastoma tumoroids: generation, biobanking and drug screening	226
Spontaneous and experimental models of lymph node metastasis	226
Expansion of human pluripotent stem cell–induced nephron progenitor cells (iNPCs) and the generation of nephron organoids from iNPCs	226
Purification and functional characterization of novel human skeletal stem cell lineages	214
Isoform-specific RNA structure determination using Nano-DMS-MaP	209
ChromEMT: visualizing and reconstructing chromatin ultrastructure and 3D organization in situ	199
Head-mounted central venous access during optical recordings and manipulations of neural activity in mice	168
How to isolate channel-forming membrane proteins using the E. coli expression system	165
Fabrication of thin-film electrodes and organic electrochemical transistors for neural implants	146
Quantitative molecular imaging using deep magnetic resonance fingerprinting	146
High-throughput fabrication of antimicrobial phage microgels and example applications in food decontamination	143
SubCellBarCode: integrated workflow for robust spatial proteomics by mass spectrometry	131
Precise tracking of nanoparticles in plant roots	126

Rapid reaction optimization by robust and economical quantitative benchtop 19F NMR spectroscopy	125
Spatially resolved epigenome sequencing via Tn5 transposition and deterministic DNA barcoding in tissue	124
Simplified ischemia-free liver transplantation with continuous normothermic machine perfusion	123
Expansion and fluctuations-enhanced microscopy for nanoscale molecular profiling of cells and tissues	111
Author Correction: Reliable detection of somatic mutations in solid tissues by laser-capture microdissection and low-input DNA sequencing	110
Author Correction: Chromatin integration labeling for mapping DNA-binding proteins and modifications with low input	109
Publisher Correction: Rapid reaction optimization by robust and economical quantitative benchtop 19F NMR spectroscopy	108
Metabolomics using anion-exchange chromatography mass spectrometry for the analysis of cells, tissues and biofluids	107
Small RNA structural biochemistry in a post-sequencing era	107
Publisher Correction: In vivo pulse labeling of isochronic cohorts of cells in the central nervous system using FlashTag	106
Sonicated inks and focused-ultrasound writing enable deep-penetration acoustic volumetric printing	105
Bioengineering human intestinal mucosal grafts using patient-derived organoids, fibroblasts and scaffolds	90
Fabrication of electron tunneling probes for measuring single-protein conductance	90
Preparation of C4′-modified nucleoside analogs	88
Preparation and biomedical applications of single-metal atom catalysts	87
Three-dimensional human neural culture on a chip recapitulating neuroinflammation and neurodegeneration	86
Photoimmunotechnology as a powerful biological tool for molecular-based elimination of target cells and microbes, including bacteria, fungi and viruses	86
Large-scale growth of C. elegans and isolation of membrane protein complexes	86
Collections from Nature Protocols	84
Gene expression and chromatin state mapped in space	82
Drosophila melanogaster as a model host for studying Pseudomonas aeruginosa feeding infection	81
Establishment of human induced trophoblast stem cells via reprogramming of fibroblasts	80
A new era for coral functional genomics	79
A practical guide to identifying associations between tandem repeats and complex human traits using consensus genotypes from multiple tools	78
A ‘print–pause–print’ protocol for 3D printing microfluidics using multimaterial stereolithography	78
Fibrous polyisocyanide hydrogels for 3D cell culture applications	78
Generation of iPSC-derived human forebrain organoids assembling bilateral eye primordia	78
Comprehensive synthesis of Ti3C2Tx from MAX phase to MXene	74
A versatile tissue-rolling technique for spatial-omics analyses of the entire murine gastrointestinal tract	73
Honey bee functional genomics using symbiont-mediated RNAi	72
Expansion of human hepatocytes and their application in three-dimensional culture and genetic manipulation	72
Mitochondrial single-cell ATAC-seq for high-throughput multi-omic detection of mitochondrial genotypes and chromatin accessibility	71
Achieving transient and reversible optical transparency in live mice with tartrazine	71
Structural connectome construction using constrained spherical deconvolution in multi-shell diffusion-weighted magnetic resonance imaging	70
Scalable growth of vertical graphene nanosheets by thermal chemical vapor deposition	69
Generation and long-term culture of human cerebellar organoids from pluripotent stem cells	68
Preparation and quantitative analysis of multicenter luminescence materials for sensing function	68
Unraveling cell–cell communication with NicheNet by inferring active ligands from transcriptomics data	66
Sequential orthogonal assays for longitudinal and endpoint characterization of three-dimensional spheroids	65
Sonoafterglow nanoprobes for deep-tissue imaging of peroxynitrite	65