OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Protocols is 67. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Author Correction: Z-REX: shepherding reactive electrophiles to specific proteins expressed tissue specifically or ubiquitously, and recording the resultant functional electrophile-induced redox respo	1206
Author Correction: cfSNV: a software tool for the sensitive detection of somatic mutations from cell-free DNA	676
Inducible CRISPR–Cas9 screening platform to interrogate non-proliferative cellular states	548
Isoform-specific RNA structure determination using Nano-DMS-MaP	520
Design and application of the transformer base editor in mammalian cells and mice	431
Routine culture and study of adult human brain cells from neurosurgical specimens	406
Open thoracic surgical implantation of cardiac pacemakers in rats	396
Spontaneous and experimental models of lymph node metastasis	305
Expansion of human pluripotent stem cell–induced nephron progenitor cells (iNPCs) and the generation of nephron organoids from iNPCs	305
Reproducible strategy for excisional skin-wound-healing studies in mice	276
GLORI for absolute quantification of transcriptome-wide m6A at single-base resolution	274
Purification and functional characterization of novel human skeletal stem cell lineages	269
Open-vessel polymerization of N-carboxyanhydride (NCA) for polypeptide synthesis	206
Visualization of metabolites and microbes at high spatial resolution using MALDI mass spectrometry imaging and in situ fluorescence labeling	204
ChromEMT: visualizing and reconstructing chromatin ultrastructure and 3D organization in situ	204
Generating human bone marrow organoids for disease modeling and drug discovery	201
Author Correction: Reliable detection of somatic mutations in solid tissues by laser-capture microdissection and low-input DNA sequencing	190
Head-mounted central venous access during optical recordings and manipulations of neural activity in mice	187
Author Correction: Chromatin integration labeling for mapping DNA-binding proteins and modifications with low input	186
Publisher Correction: Rapid reaction optimization by robust and economical quantitative benchtop 19F NMR spectroscopy	183
Preparation and biomedical applications of single-metal atom catalysts	169
Publisher Correction: In vivo pulse labeling of isochronic cohorts of cells in the central nervous system using FlashTag	161
Sonicated inks and focused-ultrasound writing enable deep-penetration acoustic volumetric printing	149
Photoimmunotechnology as a powerful biological tool for molecular-based elimination of target cells and microbes, including bacteria, fungi and viruses	146
Metabolomics using anion-exchange chromatography mass spectrometry for the analysis of cells, tissues and biofluids	146

Small RNA structural biochemistry in a post-sequencing era	145
Expansion and fluctuations-enhanced microscopy for nanoscale molecular profiling of cells and tissues	138
Fabrication of thin-film electrodes and organic electrochemical transistors for neural implants	133
SubCellBarCode: integrated workflow for robust spatial proteomics by mass spectrometry	132
Three-dimensional human neural culture on a chip recapitulating neuroinflammation and neurodegeneration	128
How to isolate channel-forming membrane proteins using the E. coli expression system	123
Precise tracking of nanoparticles in plant roots	116
Bioengineering human intestinal mucosal grafts using patient-derived organoids, fibroblasts and scaffolds	114
High-throughput fabrication of antimicrobial phage microgels and example applications in food decontamination	113
Spatially resolved epigenome sequencing via Tn5 transposition and deterministic DNA barcoding in tissue	108
Fabrication of electron tunneling probes for measuring single-protein conductance	107
Quantitative molecular imaging using deep magnetic resonance fingerprinting	104
Rapid reaction optimization by robust and economical quantitative benchtop 19F NMR spectroscopy	104
Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells	103
Large-scale growth of C. elegans and isolation of membrane protein complexes	97
Chromatin accessibility profiling by ATAC-seq	97
Collections from Nature Protocols	96
A practical guide to identifying associations between tandem repeats and complex human traits using consensus genotypes from multiple tools	95
Gene expression and chromatin state mapped in space	94
Sequential orthogonal assays for longitudinal and endpoint characterization of three-dimensional spheroids	93
Scalable growth of vertical graphene nanosheets by thermal chemical vapor deposition	87
Generation of iPSC-derived human forebrain organoids assembling bilateral eye primordia	85
Generation and long-term culture of human cerebellar organoids from pluripotent stem cells	84
mRNA lipid nanoparticle formulation, characterization and evaluation	84
Achieving transient and reversible optical transparency in live mice with tartrazine	82
Mitochondrial single-cell ATAC-seq for high-throughput multi-omic detection of mitochondrial genotypes and chromatin accessibility	82
A ‘print–pause–print’ protocol for 3D printing microfluidics using multimaterial stereolithography	82
Fibrous polyisocyanide hydrogels for 3D cell culture applications	79
A versatile tissue-rolling technique for spatial-omics analyses of the entire murine gastrointestinal tract	78
Sonoafterglow nanoprobes for deep-tissue imaging of peroxynitrite	78
Expansion of human hepatocytes and their application in three-dimensional culture and genetic manipulation	77
Unraveling cell–cell communication with NicheNet by inferring active ligands from transcriptomics data	76
Establishment of human induced trophoblast stem cells via reprogramming of fibroblasts	76
Comprehensive synthesis of Ti3C2Tx from MAX phase to MXene	74
Honey bee functional genomics using symbiont-mediated RNAi	72
Structural connectome construction using constrained spherical deconvolution in multi-shell diffusion-weighted magnetic resonance imaging	71
Preparation and quantitative analysis of multicenter luminescence materials for sensing function	70
Publisher Correction: A reconstituted cell-free assay for the evaluation of the intrinsic activity of purified human ribosomes	69
Manufacturing synthetic viscoelastic antigen-presenting cells for immunotherapy	69
Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery	69
Identification of immunogenic commensal antigens using phage display	69
Integrating genome-wide CRISPR screens and in silico drug profiling for targeted antidote development	67