OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Protocols is 65. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Author Correction: Z-REX: shepherding reactive electrophiles to specific proteins expressed tissue specifically or ubiquitously, and recording the resultant functional electrophile-induced redox respo	1108
Author Correction: cfSNV: a software tool for the sensitive detection of somatic mutations from cell-free DNA	546
Open thoracic surgical implantation of cardiac pacemakers in rats	428
Isoform-specific RNA structure determination using Nano-DMS-MaP	392
ChromEMT: visualizing and reconstructing chromatin ultrastructure and 3D organization in situ	381
Routine culture and study of adult human brain cells from neurosurgical specimens	379
Design and application of the transformer base editor in mammalian cells and mice	332
Analysis of combinatorial CRISPR screens with the Orthrus scoring pipeline	324
Visualization of metabolites and microbes at high spatial resolution using MALDI mass spectrometry imaging and in situ fluorescence labeling	272
Reproducible strategy for excisional skin-wound-healing studies in mice	269
Spontaneous and experimental models of lymph node metastasis	251
GLORI for absolute quantification of transcriptome-wide m6A at single-base resolution	231
Purification and functional characterization of novel human skeletal stem cell lineages	231
Generating human bone marrow organoids for disease modeling and drug discovery	216
Expansion of human pluripotent stem cell–induced nephron progenitor cells (iNPCs) and the generation of nephron organoids from iNPCs	213
Generation of heart-forming organoids from human pluripotent stem cells	190
Open-vessel polymerization of N-carboxyanhydride (NCA) for polypeptide synthesis	183
Quantitative molecular imaging using deep magnetic resonance fingerprinting	180
Expansion and fluctuations-enhanced microscopy for nanoscale molecular profiling of cells and tissues	170
Fabrication of electron tunneling probes for measuring single-protein conductance	169
High-throughput fabrication of antimicrobial phage microgels and example applications in food decontamination	169
Three-dimensional human neural culture on a chip recapitulating neuroinflammation and neurodegeneration	166
Metabolomics using anion-exchange chromatography mass spectrometry for the analysis of cells, tissues and biofluids	160
Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells	154
Rapid reaction optimization by robust and economical quantitative benchtop 19F NMR spectroscopy	153

Author Correction: Reliable detection of somatic mutations in solid tissues by laser-capture microdissection and low-input DNA sequencing	151
Head-mounted central venous access during optical recordings and manipulations of neural activity in mice	145
Author Correction: Chromatin integration labeling for mapping DNA-binding proteins and modifications with low input	144
Publisher Correction: Rapid reaction optimization by robust and economical quantitative benchtop 19F NMR spectroscopy	132
Photoimmunotechnology as a powerful biological tool for molecular-based elimination of target cells and microbes, including bacteria, fungi and viruses	131
How to isolate channel-forming membrane proteins using the E. coli expression system	131
Publisher Correction: In vivo pulse labeling of isochronic cohorts of cells in the central nervous system using FlashTag	131
Hyperosmolar blood–brain barrier opening using intra-arterial injection of hyperosmotic mannitol in mice under real-time MRI guidance	130
Small RNA structural biochemistry in a post-sequencing era	127
Stable isotope tracing to assess tumor metabolism in vivo	117
Fabrication of thin-film electrodes and organic electrochemical transistors for neural implants	113
Preparation and biomedical applications of single-metal atom catalysts	105
Spatially resolved epigenome sequencing via Tn5 transposition and deterministic DNA barcoding in tissue	103
Bioengineering human intestinal mucosal grafts using patient-derived organoids, fibroblasts and scaffolds	101
Chromatin accessibility profiling by ATAC-seq	99
Precise tracking of nanoparticles in plant roots	99
SubCellBarCode: integrated workflow for robust spatial proteomics by mass spectrometry	99
Establishment of human induced trophoblast stem cells via reprogramming of fibroblasts	99
Large-scale growth of C. elegans and isolation of membrane protein complexes	97
Sequential orthogonal assays for longitudinal and endpoint characterization of three-dimensional spheroids	97
Collections from Nature Protocols	96
Gene expression and chromatin state mapped in space	95
A versatile tissue-rolling technique for spatial-omics analyses of the entire murine gastrointestinal tract	94
Sonoafterglow nanoprobes for deep-tissue imaging of peroxynitrite	92
Scalable growth of vertical graphene nanosheets by thermal chemical vapor deposition	85
Fibrous polyisocyanide hydrogels for 3D cell culture applications	84
Structural connectome construction using constrained spherical deconvolution in multi-shell diffusion-weighted magnetic resonance imaging	82
Achieving transient and reversible optical transparency in live mice with tartrazine	80
mRNA lipid nanoparticle formulation, characterization and evaluation	78
Controlling the polarity of human gastrointestinal organoids to investigate epithelial biology and infectious diseases	77
Preparation and quantitative analysis of multicenter luminescence materials for sensing function	76
Honey bee functional genomics using symbiont-mediated RNAi	75
Expansion of human hepatocytes and their application in three-dimensional culture and genetic manipulation	74
Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery	74
A ‘print–pause–print’ protocol for 3D printing microfluidics using multimaterial stereolithography	73
Generation and long-term culture of human cerebellar organoids from pluripotent stem cells	70
Generation of iPSC-derived human forebrain organoids assembling bilateral eye primordia	70
Mitochondrial single-cell ATAC-seq for high-throughput multi-omic detection of mitochondrial genotypes and chromatin accessibility	68
Comprehensive synthesis of Ti3C2Tx from MAX phase to MXene	67
Unraveling cell–cell communication with NicheNet by inferring active ligands from transcriptomics data	65