Nature Chemistry

Papers
(The TQCC of Nature Chemistry is 36. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)
ArticleCitations
Not all catenanes with oriented rings are topologically chiral415
General strategy for the synthesis of N-monofluoromethyl amides305
Supramolecular crystals for hydrogen storage295
Using symmetry to drive new protein assemblies244
Pop-up rings to rule reactivity231
Digital skills in chemical education230
DNA catch bonds demonstrate the art of getting stuck221
Author Correction: Discovery of the selenium-containing antioxidant ovoselenol derived from convergent evolution219
In situ nonlinear optical spectroscopy for probing buried oxide–water interfaces194
Excited-state intermediates in a designer protein encoding a phototrigger caught by an X-ray free-electron laser192
Function without form in synthetic polymers mimicking protein hydration187
Corrole and squeezed coordination182
Building enzymes from scratch180
Sulfone cross-coupling outcompetes proton transfer172
Enantiospecific cross-coupling of cyclic alkyl sulfones169
Leveraging relaxation-optimized 1H–13CF correlations in 4-19F-phenylalanine as atomic beacons for probing structure and dynamics of large proteins161
Tunable valence tautomerism in lanthanide–organic alloys160
An air- and moisture-stable ruthenium precatalyst for diverse reactivity151
Eric the AI research assistant for chemists142
A near-linear lanthanide complex that displays magnet-like behaviour142
Discovery and synthesis of atropisomerically chiral acyl-substituted stable vinyl sulfoxonium ylides141
Iron–sulfur clusters as inhibitors and catalysts of viral replication135
Digital micelles of encoded polymeric amphiphiles for direct sequence reading and ex vivo label-free quantification133
Baird’s rules at the tipping point133
Zigzag graphene nanoribbons with periodic porphyrin edge extensions132
Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase enzymes to include non-α-amino acids in vitro and in vivo132
Protons undermine lithium-ion batteries with positively disastrous results131
Amphoteric chalcogen-bonding and halogen-bonding rotaxanes for anion or cation recognition130
A soil-inspired dynamically responsive chemical system for microbial modulation128
The numerous paths of ferrocene127
A metalloenzyme platform for catalytic asymmetric radical dearomatization126
Reversible self-assembly of small molecules for recyclable solid-state battery electrolytes126
Machine learning designs new GCGR/GLP-1R dual agonists with enhanced biological potency126
A pseudo-cubic metal–organic cage with conformationally switchable faces for dynamically adaptive guest encapsulation124
Mass spectrometry captures biased signalling and allosteric modulation of a G-protein-coupled receptor123
Enantioselective fullerene functionalization through stereochemical information transfer from a self-assembled cage120
Reaction-induced unsaturated Mo oxycarbides afford highly active CO2 conversion catalysts118
Fullerene on non-iron cluster-matrix co-catalysts promotes collaborative H2 and N2 activation for ammonia synthesis118
Single crystals of purely organic free-standing two-dimensional woven polymer networks118
O-GlcNAcylation modulates liquid–liquid phase separation of SynGAP/PSD-95117
Beyond Hubble116
Photomediated aliphatic C–H functionalization116
A living library concept to capture the dynamics and reactivity of mixed-metal clusters for catalysis115
A bridged backbone strategy enables collective synthesis of strychnan alkaloids115
A programmable biomimetic cytoskeleton114
New-to-nature biocompatible chemistry for plastic waste upcycling114
Constructing artificial gap junctions to mediate intercellular signal and mass transport113
D3+ formation through photoionization of the molecular D2–D2 dimer113
Synthesis of planar chiral ferrocenes via enantioselective remote C–H activation112
Aromaticity rules112
Homogeneous multi-payload antibody–drug conjugates112
Interfacial assembly of biomimetic MOF-based porous membranes on coacervates to build complex protocells and prototissues111
A template for artificial life111
ATP hydrolysis captured in atomic detail110
Aryl ortho methoxylation110
Bottleable triplet nitrenes109
Excitation energy transfer and vibronic coherence in intact phycobilisomes107
The ribosome stabilizes partially folded intermediates of a nascent multi-domain protein105
The role of aromaticity in the cyclization and polymerization of alkyne-substituted porphyrins on Au(111)104
Low-valent tungsten redox catalysis enables controlled isomerization and carbonylative functionalization of alkenes104
Synthesis and single-molecule imaging reveal stereospecific enhancement of binding kinetics by the antitumour eEF1A antagonist SR-A3103
A dynamic metal–organic framework photocatalyst103
Optical sequencing of single synthetic polymers103
A C–H activation-based enantioselective synthesis of lower carbo[n]helicenes102
Air- and photo-stable luminescent carbodicarbene-azaboraacenium ions102
Mass photometric detection and quantification of nanoscale α-synuclein phase separation102
Insights from an information thermodynamics analysis of a synthetic molecular motor101
Growth of single-crystal imine-linked covalent organic frameworks using amphiphilic amino-acid derivatives in water100
Multilayer stacks of polycyclic aromatic hydrocarbons100
An electroaffinity labelling platform for chemoproteomic-based target identification97
Stepwise on-demand functionalization of multihydrosilanes enabled by a hydrogen-atom-transfer photocatalyst based on eosin Y95
Challenges to developing materials for the transport and storage of hydrogen95
Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling95
Milking riboflavin for all it’s worth94
Pluralistic teaching94
Protein semisynthesis reveals plasticity in HECT E3 ubiquitin ligase mechanisms93
Small-molecule-catalysed deamination enables transcriptome-wide profiling of N6-methyladenosine in RNA92
Collisional alignment and molecular rotation control the chemi-ionization of individual conformers of hydroquinone with metastable neon92
Sustainable and degradable plastics91
An open-shell molecule that exhibits conformational dynamics90
Transient water wires mediate selective proton transport in designed channel proteins89
Enabling nucleophilic reactivity in molecular calcium fluoride complexes89
Proton-triggered topological transformation in superbase-mediated selective polymerization enables access to ultrahigh-molar-mass cyclic polymers88
A single diiron enzyme catalyses the oxidative rearrangement of tryptophan to indole nitrile88
Standardized excitable elements for scalable engineering of far-from-equilibrium chemical networks87
Three-dimensional van der Waals open frameworks87
Molecular-scale dissipative chemistry drives the formation of nanoscale assemblies and their macroscale transport86
Light-activated tetrazines enable precision live-cell bioorthogonal chemistry86
Photoswitchable coordination cages85
4f-orbital covalency enables a single-crystal-to-single-crystal ring-opening isomerization in a CeIV–cyclopropenyl complex85
Molecular contacts with an orthogonal π-skeleton induce amorphization to enhance perovskite solar cell performance85
Artificial cell synthesis using biocatalytic polymerization-induced self-assembly84
Designing artificial fluorescent proteins and biosensors by genetically encoding molecular rotor-based amino acids84
Deciphering functional roles of protein succinylation and glutarylation using genetic code expansion84
In vivo metallophilic self-assembly of a light-activated anticancer drug83
Working towards a new job83
Fast and facile synthesis of amidine-incorporated degradable lipids for versatile mRNA delivery in vivo83
Antimony cation acquired82
Unmasking the reverse catalytic activity of ‘ene’-reductases for asymmetric carbonyl desaturation81
Something new under the sun81
Author Correction: Circumventing the stability problems of graphene nanoribbon zigzag edges81
A physically encoded Bayesian assistant for the optimization of multicomponent reactions81
Anticancer platinum-based photo-oxidants in a new light80
Strong dipole-promoted N–O bond hydrogenolysis enables ampere-level electrosynthesis of methylamine79
Modular chemoenzymatic synthesis of ten fusicoccane diterpenoids78
Thickness control of organic semiconductor-incorporated perovskites78
An evolved artificial radical cyclase enables the construction of bicyclic terpenoid scaffolds via an H-atom transfer pathway78
A versatile approach for the synthesis of degradable polymers via controlled ring-opening metathesis copolymerization78
Lattice O–O ligands in Fe-incorporated hydroxides enhance water oxidation electrocatalysis78
The impact of UV light on synthetic photochemistry and photocatalysis78
Bistability between π-diradical open-shell and closed-shell states in indeno[1,2-a]fluorene78
Protein nanopore reveals the renin–angiotensin system crosstalk with single-amino-acid resolution77
Aldehyde-catalysed carboxylate exchange in α-amino acids with isotopically labelled CO276
Multi-tiered chemical proteomic maps of tryptoline acrylamide–protein interactions in cancer cells76
An isolable germylyne radical with a one-coordinate germanium atom76
Ni-catalysed assembly of axially chiral alkenes from alkynyl tetracoordinate borons via 1,3-metallate shift75
Direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes75
Atomically dispersed low-valent Au boosts photocatalytic hydroxyl radical production74
Non-statistical assembly of multicomponent [Pd2ABCD] cages74
Tricyclic cell-penetrating peptides for efficient delivery of functional antibodies into cancer cells74
Upcycling chlorinated trash into synthetic organic treasure73
Triplet metallocarbenes featuring carbon-centred spin localization73
A third strand for protein–DNA interactions73
Publisher Correction: Porous covalent organic nanotubes and their assembly in loops and toroids73
Amino amide assembly72
Heart of glass71
How polymers dance to the pulses of ultrasound70
Looking into luciferin70
Checking out metal cluster chemistry from living libraries70
Quantum simulation of conical intersections using trapped ions68
Multi-compartment liposomes forge new paths in drug delivery68
Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways67
Concurrent control over sequence and dispersity in multiblock copolymers67
Isolation of halogen-substituted silylium ions66
Tandem intermolecular [4 + 2] cycloadditions are catalysed by glycosylated enzymes for natural product biosynthesis66
Janus-type emission from a cyclometalated iron(iii) complex66
Asymmetric dearomative single-atom skeletal editing of indoles and pyrroles65
Chiral control of spin-crossover dynamics in Fe(II) complexes65
Mapping the mechanisms of oxidative addition in cross-coupling reactions catalysed by phosphine-ligated Ni(0)65
A crystalline stannyne65
Enabling late-stage drug diversification by high-throughput experimentation with geometric deep learning65
Scalable and selective deuteration of (hetero)arenes65
Total synthesis of nine longiborneol sesquiterpenoids using a functionalized camphor strategy65
Masked alkynes for synthesis of threaded carbon chains65
Discovery of the selenium-containing antioxidant ovoselenol derived from convergent evolution65
Stoichiometric two-dimensional non-van der Waals AgCrS2 with superionic behaviour at room temperature65
A proteome-wide atlas of lysine-reactive chemistry64
Spatiotemporal protein interactome profiling through condensation-enhanced photocrosslinking64
Operando film-electrochemical EPR spectroscopy tracks radical intermediates in surface-immobilized catalysts63
Electric field maps in enzymes63
The importance of community as a pre-tenure faculty member63
ChatGPT saves the day62
Asymmetric construction of sulfur(VI)–fluorine cores62
Positive climate changes62
Establishing the fundamental rules for genetic code expansion62
A lithium–aluminium heterobimetallic dimetallocene61
The gas-phase formation mechanism of iodic acid as an atmospheric aerosol source61
Multi-site programmable functionalization of alkenes via controllable alkene isomerization61
Polymer connectivity governs electrophotocatalytic activity in the solid state61
Cyclopropenium functionalization61
Designer peptide–DNA cytoskeletons regulate the function of synthetic cells61
A terminal neptunium(V)–mono(oxo) complex61
Photocatalytic nitrogen fixation under an ambient atmosphere using a porous coordination polymer with bridging dinitrogen anions61
The dynamics of agonist-β2-adrenergic receptor activation induced by binding of GDP-bound Gs protein61
Direct dynamic read-out of molecular chirality with autonomous enzyme-driven swimmers61
A bismuth-based analogue of the π-allyl cation61
Mimicking the structure and function of tau folds associated with disease61
Exciton annihilation in molecular aggregates suppressed through quantum interference60
Non-enzymatic methylcyclization of alkenes60
On gene silencing by the X10-23 DNAzyme60
Structure-specific amyloid precipitation in biofluids60
Ten-electron count rule for the binding of adsorbates on single-atom alloy catalysts59
Using supramolecular machinery to engineer directional charge propagation in photoelectrochemical devices59
Encoding signal propagation on topology-programmed DNA origami59
End-of-life upcycling of polyurethanes using a room temperature, mechanism-based degradation59
Experimental quantitation of molecular conditions responsible for flow-induced polymer mechanochemistry59
A chiral interlocking auxiliary strategy for the synthesis of mechanically planar chiral rotaxanes58
Uniform segmented platelet micelles with compositionally distinct and selectively degradable cores58
How many roads must a woman walk down?57
Zinc and manganese redox potentials in organic solvents and their influence on nickel-catalysed cross-electrophile coupling57
Adaptive insertion of a hydrophobic anchor into a poly(ethylene glycol) host for programmable surface functionalization57
Chemical testing57
Rings of power56
A molecular sandwich with a lithium–aluminium filling56
Hydrogenative double-bond deuteration56
Ethics education for chemists56
Doing away with radium’s proxies56
Flexible interaction patches lead to building blocks with fluctuating valency55
Photoinduced stepwise charge hopping in π-stacked perylene bisimide donor–bridge–acceptor arrays55
Interweaving different metal–organic frameworks55
Stereoselective alkylation of saturated heterocycles55
Selection of a promiscuous minimalist cAMP phosphodiesterase from a library of de novo designed proteins54
Colouring by force54
Author Correction: Moiré two-dimensional covalent organic framework superlattices54
Diversified ring expansion of saturated cyclic amines enabled by azlactone insertion53
Building ultramicroporous zirconium metal‒organic frameworks with ligands of high coordination density through a reticular approach52
Molecular basis for the diversification of lincosamide biosynthesis by pyridoxal phosphate-dependent enzymes51
Ion-pair reorganization regulates reactivity in photoredox catalysts49
Efficient room-temperature phosphorescence of covalent organic frameworks through covalent halogen doping49
Direct conversion of white phosphorus to versatile phosphorus transfer reagents via oxidative onioation49
Hydrophobic assembly of molecular catalysts at the gas–liquid–solid interface drives highly selective CO2 electromethanation49
Active template strategy for the preparation of π-conjugated interlocked nanocarbons48
Nanoparticle stereochemistry-dependent endocytic processing improves in vivo mRNA delivery48
A general alkene aminoarylation enabled by N-centred radical reactivity of sulfinamides48
Different timescales during ultrafast stilbene isomerization in the gas and liquid phases revealed using time-resolved photoelectron spectroscopy48
Recyclable and malleable thermosets enabled by activating dormant dynamic linkages48
Isolation and characterization of a two-coordinate phosphinidene oxide47
Reconfiguring hydrogel assemblies using a photocontrolled metallopolymer adhesive for multiple customized functions47
Decarboxylative cross-nucleophile coupling via ligand-to-metal charge transfer photoexcitation of Cu(ii) carboxylates47
Near-infrared-activated anticancer platinum(IV) complexes directly photooxidize biomolecules in an oxygen-independent manner47
A para- to meta-isomerization of phenols47
Chemical upcycling of commodity thermoset polyurethane foams towards high-performance 3D photo-printing resins47
Heteromultivalency enables enhanced detection of nucleic acid mutations47
Intramolecular alkene and functional group translocation46
Hydrogen splitting at a single phosphorus centre and its use for hydrogenation46
Quinine fever46
Publisher Correction: OregonFluor enables quantitative intracellular paired agent imaging to assess drug target availability in live cells and tissues46
Copper catalysed asymmetric amination45
Critical race theory and its relevance for chemistry45
Observation of robust energy transfer in the photosynthetic protein allophycocyanin using single-molecule pump–probe spectroscopy45
From geranium lakes to catalysis with light45
Fused radical SAM and αKG-HExxH domain proteins contain a distinct structural fold and catalyse cyclophane formation and β-hydroxylation45
Structural basis of the Meinwald rearrangement catalysed by styrene oxide isomerase45
WT19F44
Iterative synthesis of 1,3-polyboronic esters with high stereocontrol and application to the synthesis of bahamaolide A44
Halogen-bond-assisted radical activation of glycosyl donors enables mild and stereoconvergent 1,2-cis-glycosylation44
Tunable and recyclable polyesters from CO2 and butadiene44
Emulsion-oriented assembly for Janus double-spherical mesoporous nanoparticles as biological logic gates44
Navigating protein landscapes with a machine-learned transferable coarse-grained model44
Release of linker histone from the nucleosome driven by polyelectrolyte competition with a disordered protein44
Low-temperature liquid platinum catalyst44
Modular enantioselective access to β-amino amides by Brønsted acid-catalysed multicomponent reactions44
Supercrystal engineering of atomically precise gold nanoparticles promoted by surface dynamics44
Synthesis of highly strained para-cyclophanes via ring-expansion [5,5]-sigmatropic rearrangement reaction44
Biosynthesis of an elusive sulfur-containing functional group44
Time-resolved terahertz–Raman spectroscopy reveals that cations and anions distinctly modify intermolecular interactions of water43
An unnatural base pair for the detection of epigenetic cytosine modifications in DNA43
Triarylmethyl cation redox mediators enhance Li–O2 battery discharge capacities43
Recyclable plastics from a manganese catalyst43
Arenes participate in 1,3-dipolar cycloaddition with in situ-generated diazoalkenes42
Carbonyl cross-metathesis via deoxygenative gem-di-metal catalysis42
The fruit fly of photophysics42
Tunable acetylene sorption by flexible catenated metal–organic frameworks42
Mirror-image trypsin digestion and sequencing of D-proteins42
Structure-informed design of an ultrabright RNA-activated fluorophore42
Enhanced active-site electric field accelerates enzyme catalysis42
Progress and pitfalls in designing heterogeneous catalysts with molecular precision42
The enlightening history of sodium carbonate41
Ultrafast electronic relaxation pathways of the molecular photoswitch quadricyclane41
An NmrA-like enzyme-catalysed redox-mediated Diels–Alder cycloaddition with anti-selectivity41
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