OOIR: Observatory of International Research

Papers

(The TQCC of Molecular Brain is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
mTORC1-mediated acquisition of reward-related representations by hippocampal somatostatin interneurons	140
Protocadherin 19 regulates axon guidance in the developing Xenopus retinotectal pathway	101
Inhibition of cortical synaptic transmission, behavioral nociceptive, and anxiodepressive-like responses by arecoline in adult mice	73
FMRP binds Per1 mRNA and downregulates its protein expression in mice	54
Correction to: Synaptic potentiation of anterior cingulate cortex contributes to chronic pain of Parkinson’s disease	46
Correction to: Roles of Rufy3 in experimental subarachnoid hemorrhage-induced early brain injury via accelerating neuronal axon repair and synaptic plasticity	45
Spatiotemporal Pavlovian head-fixed reversal learning task for mice	38
A novel mouse model for investigating α-synuclein aggregates in oligodendrocytes: implications for the glial cytoplasmic inclusions in multiple system atrophy	35
Diurnal variation in declarative memory and the involvement of SCOP in cognitive functions in nonhuman primates	35
Knockout of AMPA receptor binding protein Neuron-specific gene 2 (NSG2) enhances associative learning and cognitive flexibility	34
Recent developments in peptide vaccines against Glioblastoma, a review and update	33
Npas4 regulates synaptic development in the patch/striosome compartment and early affective vocalization in neonatal mice	31
Broad proteomics analysis of seeding-induced aggregation of α-synuclein in M83 neurons reveals remodeling of proteostasis mechanisms that might contribute to Parkinson’s disease pathogenesis	30
Chronic corticosterone exposure causes anxiety- and depression-related behaviors with altered gut microbial and brain metabolomic profiles in adult male C57BL/6J mice	29
Chronic oral administration of ibrutinib prevents long-term memory deficits and reduces AD pathology and neuroinflammatory responses in a mouse model of AD	28
Impact of volume and expression time in an AAV-delivered channelrhodopsin	28
Upregulation of TRPV2 exacerbates age-related hearing loss by promoting oxidative stress in spiral ganglion neurons	27
Role of autophagy in neurotoxic protein’s clearance following post-ischemic stroke: where we are and what we know?	27
m6A RNA methylation in neural plasticity, brain aging, and neurodegenerative vulnerability	26
A simple and reliable method for claustrum localization across age in mice	23
Dynamic changes in the hippocampal neuronal circuits activity following acute stress revealed by miniature fluorescence microscopy imaging	23
Histamine H3 receptor inverse agonists/antagonists influence intra-regional cortical activity and inter-regional synchronization during resting state: an exploratory cortex-wide imaging study in mice	22
Correction to: Synergistic actions of corticosterone and BDNF on rat hippocampal LTP	20
Correction: The deficiency of Maged1 attenuates Parkinson’s disease progression in mice	20
Chronic stress increases the susceptibility to chronic vulvar pain following acute vulvar inflammation in a preclinical model of vulvodynia	20

The brain cytokine orchestra in multiple sclerosis: from neuroinflammation to synaptopathology	19
AKAP6 controls NFATc4 activity for BDNF-mediated neuroprotection	19
Riluzole partially restores RNA polymerase III complex assembly in cells expressing the leukodystrophy-causative variant POLR3B R103H	19
Sonic hedgehog signalling pathway in CNS tumours: its role and therapeutic implications	18
The terpenes alpha-bisabolol and camphene modulate pruritus via an action on Cav3.2 T-type calcium channels	18
Novelty-induced memory consolidation is accompanied by increased Agap3 transcription: a cross-species study	18
Post-conditioning sleep deprivation facilitates delay and trace fear memory extinction	18
Selective enhancement of fear extinction by inhibiting neuronal adenylyl cyclase 1 (AC1) in aged mice	18
Involvement of posterior hypothalamic CaMKII-positive neurons in ADHD-like behaviors in mice	18
Chemogenetic activation of histamine neurons promotes retrieval of apparently lost memories	18
MeCP2 deficiency impairs motor cortical circuit flexibility associated with motor learning	16
Reduced activity of parvalbumin-positive interneurons in the posterior parietal cortex causes visually dominant multisensory decisions in freely navigating mice	16
Subacute and chronic proteomic and phosphoproteomic analyses of a mouse model of traumatic brain injury at two timepoints and comparison with chronic traumatic encephalopathy in human samples	16
Olfactory marker protein contains a leucine-rich domain in the Ω-loop important for nuclear export	16
Organoids as next-generation models for investigating intracranial tumours	15
Chronic pain enhances excitability of corticotropin-releasing factor-expressing neurons in the oval part of the bed nucleus of the stria terminalis	15
Pathophysiology of ion channels in amyotrophic lateral sclerosis	14
Neurexin-3 in the paraventricular nucleus of the hypothalamus regulates body weight and glucose homeostasis independently of food intake	14
Increased social interaction in Shank2-deficient mice following acute social isolation	14
Moxibustion ameliorates chronic inflammatory visceral pain via spinal circRNA-miRNA-mRNA networks: a central mechanism study	14
A new paradigm of learned cooperation reveals extensive social coordination and specific cortical activation in mice	14
mTORC1 function in hippocampal parvalbumin interneurons: regulation of firing and long-term potentiation of intrinsic excitability but not long-term contextual fear memory and context discrimination	13
The gut microbiota and metabolite profiles are altered in patients with spinal cord injury	13
Mycophenolate mofetil reduces the branching of microglial processes	13
Sonication dissociates the synaptic cleft and allows purification of postsynaptic densities with associated postsynaptic membrane	13
Spermidine treatment: induction of autophagy but also apoptosis?	13
Intravitreal injection of the Galectin-3 inhibitor TD139 provides neuroprotection in a rat model of ocular hypertensive glaucoma	13
Chronic skin ultraviolet irradiation induces transcriptomic changes associated with microglial dysfunction in the hippocampus	12
Novelty triggers time-dependent theta oscillatory dynamics in cortical-hippocampal-midbrain circuitry	12
Profiling tyrosine kinase inhibitors as AD therapeutics in a mouse model of AD	12
High glucose and palmitic acid induces neuronal senescence by NRSF/REST elevation and the subsequent mTOR-related autophagy suppression	12
Region-specific activation in the accumbens nucleus by itch with modified scratch efficacy in mice – a model-free multivariate analysis	12
TREM2 improves microglia function and synaptic development in autism spectrum disorders by regulating P38 MAPK signaling pathway	12
Unaltered empathy-related behaviors in Williams–Beuren syndrome mouse models	12
Changes in oligodendroglial subpopulations in Parkinson’s disease	12
Toll-like receptors and their role in neuropathic pain and migraine	12
Neuropathological and behavioral features of an APP/PS1/MAPT (6xTg) transgenic model of Alzheimer’s disease	11
Repeated naloxone-induced morphine withdrawal alters blood brain barrier and blood spinal cord barrier integrity in mice	11
Artificial intelligence-based biomarkers for the diagnosis and treatment of neurological conditions: a narrative review	11
Elucidation of the mechanisms underlying tumor aggravation by the activation of stress-related neurons in the paraventricular nucleus of the hypothalamus	11
Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid pathology and switches astrocytes from a reactive to active state	11
Activation of angiotensin-converting enzyme 2 produces an antidepressant-like effect via MAS receptors in mice	11
Limitations of the human iPSC-derived neuron model for early-onset Alzheimer’s disease	10
A new AAV tool for highly preferentially targeting hippocampal CA2	10
Genetic deletion of nitric oxide synthase 2 ameliorates Parkinson’s disease pathology and neuroinflammation in a transgenic mouse model of synucleinopathy	10
Spinal microglia contribute to sustained inflammatory pain via amplifying neuronal activity	10
NEK7 induces lactylation in Alzheimer’s disease to promote pyroptosis in BV-2 cells	10
Correction: Requirement for hippocampal CA3 NMDA receptors in artificial association of memory events stored in CA3 cell ensembles	10
Analysis of neurexin-neuroligin complexes supports an isoform-specific role for beta-neurexin-1 dysfunction in a mouse model of autism	9
Crucial role of TFAP2B in the nervous system for regulating NREM sleep	9

Correction: Extinction of contextual fear memory is facilitated in TRPM2 knockout mice	9
Loss of mitochondrial enzyme GPT2 leads to reprogramming of synaptic glutamate metabolism	9
Age-related attenuation of cortical synaptic tagging in the ACC is rescued by BDNF or a TrkB receptor agonist in both sex of mice	9
Nek6 regulates autophagy through the mTOR signaling pathway to alleviate cerebral ischemia–reperfusion injury	9
Aging-independent decrease of complex multi-spine boutons in hippocampal area CA1 after contextual fear conditioning	9
Astrocytic activation increases blood flow in the adult olfactory bulb	9
Acupuncture improves depressive-like behaviors in CUMS rats by modulating lateral habenula synaptic plasticity via the BDNF/ERK/mTOR pathway	9
Behavioral phenotype, intestinal microbiome, and brain neuronal activity of male serotonin transporter knockout mice	9
Generation of a new Slc20a2 knockout mouse line as in vivo model for primary brain calcification	9
AldoC BAC-GFP transgenic mice as a reliable model for astrocyte identification and functional studies in the brain	9
Synergistic actions of corticosterone and BDNF on rat hippocampal LTP	8
Neurexin-1-dependent circuit activity is required for the maintenance of photoreceptor subtype identity in Drosophila	8
Peripheral-central network analysis of cancer cachexia status accompanied by the polarization of hypothalamic microglia with low expression of inhibitory immune checkpoint receptors	8
PV-IRES-Cre mouse line targets excitatory granule neurons in the cerebellum	8
Outer layer of Vb neurons in medial entorhinal cortex project to hippocampal dentate gyrus in mice	8
Disruption of protein geranylgeranylation in the cerebellum causes cerebellar hypoplasia and ataxia via blocking granule cell progenitor proliferation	8
Experience-dependent changes in affective valence of taste in male mice	8
Targeted NMDA receptor knockdown in recall‐activated neuronal ensembles impairs remote fear extinction	8
Acute social defeat stress activated neurons project to the claustrum and basolateral amygdala	8
The medial prefrontal cortex encodes procedural rules as sequential neuronal activity dynamics	8
Hypothalamic protein profiling from mice subjected to social defeat stress	8
Human midbrain organoids reveal the characteristics of axonal mitochondria specific to dopaminergic neurons	8
Central nervous system pericytes express soluble ST2 in inflammation and injury	8
The absence of Neuroligin-1 shapes wake/sleep architecture, rhythmic and arrhythmic activities of the electrocorticogram in female mice	8