OOIR: Observatory of International Research

Papers

(The TQCC of Molecular Brain is 10. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
LncRNA MALAT1 facilitates inflammasome activation via epigenetic suppression of Nrf2 in Parkinson’s disease	90
Interleukin-17 induced by cumulative mild stress promoted depression-like behaviors in young adult mice	59
Cell therapy for spinal cord injury by using human iPSC-derived region-specific neural progenitor cells	49
Metallothionein-3 as a multifunctional player in the control of cellular processes and diseases	48
Genetic associations between voltage-gated calcium channels and autism spectrum disorder: a systematic review	43
Alterations in the gut microbiota and metabolite profiles in the context of neuropathic pain	43
Altered dopaminergic pathways and therapeutic effects of intranasal dopamine in two distinct mouse models of autism	42
Ketamine and its metabolite, (2R,6R)-HNK, restore hippocampal LTP and long-term spatial memory in the Wistar-Kyoto rat model of depression	41
Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia	38
RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection	37
Astrocyte metabolism of the medium-chain fatty acids octanoic acid and decanoic acid promotes GABA synthesis in neurons via elevated glutamine supply	36
Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/β-catenin, and mTOR signaling during corticogenesis	35
Effects of test experience, closed-arm wall color, and illumination level on behavior and plasma corticosterone response in an elevated plus maze in male C57BL/6J mice: a challenge against conventiona	35
Blood–brain barrier: emerging trends on transport models and new-age strategies for therapeutics intervention against neurological disorders	35
Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice	32
Endoplasmic reticulum retention and degradation of a mutation in SLC6A1 associated with epilepsy and autism	31
GABAergic neuron-specific whole-brain transduction by AAV-PHP.B incorporated with a new GAD65 promoter	28
Side-by-side comparison of the effects of Gq- and Gi-DREADD-mediated astrocyte modulation on intracellular calcium dynamics and synaptic plasticity in the hippocampal CA1	28
Central and peripheral contributions of T-type calcium channels in pain	27
Influence of maternal zinc supplementation on the development of autism-associated behavioural and synaptic deficits in offspring Shank3-knockout mice	27
Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial Alzheimer’s disease	27
The BDNF-FoxO1 Axis in the medial prefrontal cortex modulates depressive-like behaviors induced by chronic unpredictable stress in postpartum female mice	27
Region-specific distribution of Olig2-expressing astrocytes in adult mouse brain and spinal cord	27
Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex	26
Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases	26

Increased O-GlcNAcylation of Drp1 by amyloid-beta promotes mitochondrial fission and dysfunction in neuronal cells	26
Roles of palmitoylation in structural long-term synaptic plasticity	26
AAV9-Retro mediates efficient transduction with axon terminal absorption and blood–brain barrier transportation	25
Antibiotics-induced intestinal dysbacteriosis caused behavioral alternations and neuronal activation in different brain regions in mice	25
Translational changes induced by acute sleep deprivation uncovered by TRAP-Seq	23
TMEM175 mediates Lysosomal function and participates in neuronal injury induced by cerebral ischemia-reperfusion	22
Cortico-amygdala interaction determines the insular cortical neurons involved in taste memory retrieval	22
The voltage-gated proton channel Hv1 promotes microglia-astrocyte communication and neuropathic pain after peripheral nerve injury	21
S100B is selectively expressed by gray matter protoplasmic astrocytes and myelinating oligodendrocytes in the developing CNS	21
mGluR5 regulates REST/NRSF signaling through N-cadherin/β-catenin complex in Huntington’s disease	21
Proteomic insights into synaptic signaling in the brain: the past, present and future	21
Circadian rhythms in the blood–brain barrier: impact on neurological disorders and stress responses	20
Progress on the roles of MEF2C in neuropsychiatric diseases	20
The terpenes camphene and alpha-bisabolol inhibit inflammatory and neuropathic pain via Cav3.2 T-type calcium channels	20
Assessing the effect of interaction between C-reactive protein and gut microbiome on the risks of anxiety and depression	19
The role m6A RNA methylation is CNS development and glioma pathogenesis	19
Characterization of a pathogenic variant in GBA for Parkinson’s disease with mild cognitive impairment patients	19
Altered hippocampal transcriptome dynamics following sleep deprivation	19
Intraventricular IL-17A administration activates microglia and alters their localization in the mouse embryo cerebral cortex	19
CCL2 facilitates spinal synaptic transmission and pain via interaction with presynaptic CCR2 in spinal nociceptor terminals	19
Toll-like receptors and their role in neuropathic pain and migraine	18
Kappa opioid receptors in the central amygdala modulate spinal nociceptive processing through an action on amygdala CRF neurons	18
Genetic deletion of microRNA-22 blunts the inflammatory transcriptional response to status epilepticus and exacerbates epilepsy in mice	18
Contribution of central sensitization to stress-induced spreading hyperalgesia in rats with orofacial inflammation	17
A novel red fluorescence dopamine biosensor selectively detects dopamine in the presence of norepinephrine in vitro	17
The voltage-gated proton channel Hv1 contributes to neuronal injury and motor deficits in a mouse model of spinal cord injury	17
Peripheral nerve injury reduces the excitation-inhibition balance of basolateral amygdala inputs to prelimbic pyramidal neurons projecting to the periaqueductal gray	16
Impaired pattern separation in Tg2576 mice is associated with hyperexcitable dentate gyrus caused by Kv4.1 downregulation	16
Simvastatin impairs hippocampal synaptic plasticity and cognitive function in mice	16
Decreased expression of the clock gene Bmal1 is involved in the pathogenesis of temporal lobe epilepsy	16
GDF11 expressed in the adult brain negatively regulates hippocampal neurogenesis	16
Aversive emotion rapidly activates orexin neurons and increases heart rate in freely moving mice	16
Non-SUMOylated CRMP2 decreases NaV1.7 currents via the endocytic proteins Numb, Nedd4-2 and Eps15	16
Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons	16
The dual roles of autophagy and the GPCRs-mediating autophagy signaling pathway after cerebral ischemic stroke	16
Functional organization of the midbrain periaqueductal gray for regulating aversive memory formation	16
Anxiolytic effect of GABAergic neurons in the anterior cingulate cortex in a rat model of chronic inflammatory pain	16
Optimization of protocols for pre-embedding immunogold electron microscopy of neurons in cell cultures and brains	15
Endosomal dysfunction in iPSC-derived neural cells from Parkinson’s disease patients with VPS35 D620N	15
Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson’s disease model	15
Long-range GABAergic projections from the nucleus of the solitary tract	15
Ferroptosis participates in neuron damage in experimental cerebral malaria and is partially induced by activated CD8+ T cells	15
APOE genotype dependent molecular abnormalities in the cerebrovasculature of Alzheimer’s disease and age-matched non-demented brains	15
2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2- and H3 histamine autoreceptors	15
Brain-derived neurotrophic factor produced long-term synaptic enhancement in the anterior cingulate cortex of adult mice	15
Schizophrenia-associated dysbindin modulates axonal mitochondrial movement in cooperation with p150glued	15
Optogenetics: implications for Alzheimer’s disease research and therapy	15
Reductions in midbrain GABAergic and dopamine neuron markers are linked in schizophrenia	15
Relief of neuropathic pain by cell-specific manipulation of nucleus accumbens dopamine D1- and D2-receptor-expressing neurons	14
Age-related increase in caveolin-1 expression facilitates cell-to-cell transmission of α-synuclein in neurons	14

PDK1 regulates the survival of the developing cortical interneurons	14
Intranasal oxytocin administration ameliorates social behavioral deficits in a POGZWT/Q1038R mouse model of autism spectrum disorder	14
Cav3.2 T-type calcium channels control acute itch in mice	14
Pathological alterations in striatal compartments in the human brain of autism spectrum disorder	14
Fibroblasts from idiopathic Parkinson’s disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2	13
The Sigma 2 receptor promotes and the Sigma 1 receptor inhibits mu-opioid receptor-mediated antinociception	13
Axl receptor tyrosine kinase is a regulator of apolipoprotein E	13
A critical role of hippocampus for formation of remote cued fear memory	13
Cortactin deacetylation by HDAC6 and SIRT2 regulates neuronal migration and dendrite morphogenesis during cerebral cortex development	13
Schizophrenia risk ZNF804A interacts with its associated proteins to modulate dendritic morphology and synaptic development	13
Caveolin-1 deficiency impairs synaptic transmission in hippocampal neurons	13
Yin Yang 1 is critical for mid-hindbrain neuroepithelium development and involved in cerebellar agenesis	13
Diverse inflammatory threats modulate astrocytes Ca2+ signaling via connexin43 hemichannels in organotypic spinal slices	13
D1 receptors in the anterior cingulate cortex modulate basal mechanical sensitivity threshold and glutamatergic synaptic transmission	13
Distribution of five clinically important neuroglial proteins in the human brain	13
Reversibility of motor dysfunction in the rat model of NGLY1 deficiency	13
Beta amyloid deposition and cognitive decline in Parkinson’s disease: a study of the PPMI cohort	12
Disruption of the astrocyte–neuron interaction is responsible for the impairments in learning and memory in 5XFAD mice: an Alzheimer’s disease animal model	12
The increased in vivo firing of pyramidal cells but not interneurons in the anterior cingulate cortex after neuropathic pain	12
Propionic acid induces dendritic spine loss by MAPK/ERK signaling and dysregulation of autophagic flux	12
Adult neurogenesis mediates forgetting of multiple types of memory in the rat	12
Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer’s disease	12
Alleviating toxic α-Synuclein accumulation by membrane depolarization: evidence from an in vitro model of Parkinson’s disease	12
In vivo imaging of immediate early gene expression dynamics segregates neuronal ensemble of memories of dual events	12
Peptidome analysis of cerebrospinal fluid in neonates with hypoxic-ischemic brain damage	12
Integrin β3 organizes dendritic complexity of cerebral cortical pyramidal neurons along a tangential gradient	12
Further evidence that CP-AMPARs are critically involved in synaptic tag and capture at hippocampal CA1 synapses	12
Serotonergic gene-to-gene interaction is associated with mood and GABA concentrations but not with pain-related cerebral processing in fibromyalgia subjects and healthy controls	11
Conditional Pten knockout in parvalbumin- or somatostatin-positive neurons sufficiently leads to autism-related behavioral phenotypes	11
A two-compartment model of synaptic computation and plasticity	11
Altered striatal dopamine levels in Parkinson’s disease VPS35 D620N mutant transgenic aged mice	11
The VEGF inhibitor vatalanib regulates AD pathology in 5xFAD mice	11
Overexpression of Slit2 decreases neuronal excitotoxicity, accelerates glymphatic clearance, and improves cognition in a multiple microinfarcts model	11
Conditional knock out of transcription factor CTCF in excitatory neurons induces cognitive deficiency	11
Distinct role of 5′UTR sequences in dendritic trafficking of BDNF mRNA: additional mechanisms for the BDNF splice variants spatial code	11
GPR68 deletion impairs hippocampal long-term potentiation and passive avoidance behavior	11
Brain region networks for the assimilation of new associative memory into a schema	11
Modeling PTEN overexpression-induced microcephaly in human brain organoids	11
Retrosplenial cortex in spatial memory: focus on immediate early genes mapping	11
The de novo CACNA1A pathogenic variant Y1384C associated with hemiplegic migraine, early onset cerebellar atrophy and developmental delay leads to a loss of Cav2.1 channel function	11
iTRAQ-based proteomic profiling reveals protein alterations after traumatic brain injury and supports thyroxine as a potential treatment	11
Enhanced contextual fear memory in peroxiredoxin 6 knockout mice is associated with hyperactivation of MAPK signaling pathway	11
Sodium valproate increases activity of the sirtuin pathway resulting in beneficial effects for spinocerebellar ataxia-3 in vivo	11
Chd8 mutation in oligodendrocytes alters microstructure and functional connectivity in the mouse brain	11
A CACNA1A variant associated with trigeminal neuralgia alters the gating of Cav2.1 channels	11
Altered behavior in mice overexpressing soluble ST2	11
Intrinsic braking role of descending locus coeruleus noradrenergic neurons in acute and chronic itch in mice	10
Increased ribosomal protein levels and protein synthesis in the striatal synaptosome of Shank3-overexpressing transgenic mice	10
Nicotinamide, a vitamin B3 ameliorates depressive behaviors independent of SIRT1 activity in mice	10
Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in	10
The parabrachial-to-amygdala pathway provides aversive information to induce avoidance behavior in mice	10
Altered functional connectivity between hypothalamus and limbic system in fibromyalgia	10
MeCP2 gates spatial learning-induced alternative splicing events in the mouse hippocampus	10
Inositol hexakisphosphate kinase-1 is a key mediator of prepulse inhibition and short-term fear memory	10
Knockdown of Son, a mouse homologue of the ZTTK syndrome gene, causes neuronal migration defects and dendritic spine abnormalities	10
Decreased in vivo glutamate/GABA ratio correlates with the social behavior deficit in a mouse model of autism spectrum disorder	10
Cocaine-induced neuron subtype mitochondrial dynamics through Egr3 transcriptional regulation	10
Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates	10
Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down’s syndrome mouse model	10