Future Medicinal Chemistry

Article	Citations
Biological and computational evaluation of novel benzofuranyl derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors	57
Targeting Tuberculosis – An Interview With Robert Abramovitch	51
Identification of Sulfonamide-Based Butyrylcholinesterase Inhibitors Using Machine Learning	46
The Connection Between PARP14 and SARS-CoV-2	45
In vivo evaluation of novel synthetic pyrazolones as CDK9 inhibitors with enhanced pharmacokinetic properties	45
Combining EGFR Inhibitors With SHP2 Or LSD1 Inhibitors to Overcome Multidrug Resistance in Cancer	37
Citrate Transporter Inhibitors: Possible New Anticancer Agents	37
A Review of Current and Promising Nontuberculous Mycobacteria Antibiotics	37
Therapeutic N -Heterocyclic Carbenes: An Interview With Alejandro Bugarin	37
PPARγ Transcription Effect on Naturally Occurring O -Prenyl Cinnamaldehydes and Cinnamyl Alcohol Derivatives	33
Sulfonamide-salicylaldehyde Imines Active Against methicillin- and trimethoprim/sulfonamide-resistant Staphylococci	32
Investigations of New N 1 -Substituted Pyrazoles as Anti-Inflammatory and Analgesic Agents having COX Inhibitory Act	31
Selection of SARS-CoV-2 Main Protease Inhibitor Using Structure-Based Virtual Screening	29
Design of SARS-CoV-2 Mpro, PLpro Dual-Target Inhibitors Based on Deep Reinforcement Learning and Virtual Screening	28
Design and synthesis of new nicotinamides as immunomodulatory VEGFR-2 inhibitors and apoptosis inducers	27
Super-Conserved Receptors Expressed in the Brain: Biology and Medicinal Chemistry Efforts	27
Novel Set of Highly Substituted Bis-Pyridines: Synthesis, Molecular Docking and Drug-Resistant Antibacterial Profile	26
Combining Structure-Based and 3D QSAR Pharmacophore Models to Discover Diverse Ligands Against EGFR in Oral Cancer	26
Development of 5-hydroxybenzothiophene derivatives as multi-kinase inhibitors with potential anti-cancer activity	26
Advances in AR-Targeting Chimeras: A Case Study of proteolysis-targeting Chimeras From Bench to Bedside	24
New pyrrolopyridine-based Thiazolotriazoles As Diabetics Inhibitors: Enzymatic Kinetics and In Silico Study	22
A New Class of 5-HT 1A Receptor Antagonists With Procognitive and Antidepressant Properties	21
Basic nitrogen (BaN): a ‘privileged element’ in medicinal chemistry	21
Discovery of Novel Covalent Inhibitors of DJ-1 Through Hybrid Virtual Screening	19
5,7,3′,4′-Tetramethoxyflavone Ameliorates Cholesterol Dysregulation by Mediating SIRT1/FOXO3a/ABCA1 Signaling in Osteoarthritis Chondrocytes	19

Synthesis of Hydrazinyl–Thiazole Ester Derivatives, in Vitro Trypanocidal and Leishmanicidal Activities	19
Diaminomaleonitrile Derivatives as new Potential Antichagasic Compounds: A Study of Structure–Activity Relationships	19
Rh(III) and Ru(II) Complexes With Phosphanyl–Alkylamines: Inhibition of DNA Synthesis Induced By Anticancer Rh Complex	18
Synergistic effect of new pyrimidine derivative with oxacilin against methicillin-resistant Staphylococcus aureus	18
Barbiturate–sulfonate hybrids as potent cholinesterase inhibitors: design, synthesis and molecular modeling studies	18
Propargylamine: an Important Moiety in Drug Discovery	18
Synthesis, in vitro and in silico anticancer evaluation of novel pyridin-2-yl estra-1,3,5(10)-triene derivatives	17
Design, synthesis and inhibition evaluation of novel chalcone amide α-glucosidase inhibitors	16
Computational Insights Into Novel Inhibitor Indole-Heterocycle Specific Against Glycogen Phosphorylase Isoenzymes Interaction Mechanism	16
HDAC8 As an Emerging Target in Drug Discovery With Special Emphasis on Medicinal Chemistry	16
Novel Xylenyl-Spaced Bis-Thiazoles/Thiazines: Synthesis, Biological Profile as Herpes Simplex Virus Type 1 Inhibitors and in Silico Simulations	16
Machine Learning and Deep Learning in Data-Driven Decision Making of Drug Discovery and Challenges in High-Quality Data Acquisition in the Pharmaceutical Industry	15
Keto-Bridged Dual Triazole-Linked Benzenesulfonamides As Potent Carbonic Anhydrase and Cathepsin B Inhibitors	15
Medicinal Chemistry in Big Pharma has a Gender Diversity Problem	15
Recent Advancements in the Discovery of Cereblon-Based Protease-Targeted Chimeras With Potential for Therapeutic Intervention	14
Copper(II) complexes of 2-hydroxy-1-naphthaldehyde Schiff bases: synthesis, in vitro activity and computational studies	14
Unlocking the power of imidazoquinolines: recent advances in anticancer and immunotherapeutic strategies	14
Synthesis of indole-functionalized isoniazid conjugates with potent antimycobacterial and antioxidant efficacy	13
HIV-1 Capsid Inhibitors: A Sword to Destroy the Virus	13
Management of Adenocarcinoma With Honokiol: Progress So Far and the Way Forward	13
Targeting TGF-β: Triumphs and Challenges	13
GANT61 Elevates Chemosensitivity to Cisplatin Through Regulating the Hedgehog, AMPK and cAMP Pathways in Ovarian Cancer	13
γ-Secretase As a Drug Target for Familial Alzheimer's Disease: The Road Less Traveled	13
Potent α-glucosidase inhibitors with benzimidazole-propionitrile hybridization; synthesis, bioassay and docking study	13
Computational Repurposing of Benzimidazole Anthelmintic Drugs As Potential Colchicine Binding Site Inhibitors	13
Autophagy degradation: a promising dimension in drug discovery for neurodegenerative diseases	12
Design, Synthesis and Antitumor Activity of Novel pyran-functionalized Uracil Derivatives: Docking Studies	12
The versatility of phenothiazines as an anticancer drug scaffold	12
How does machine learning augment alchemical binding free energy calculations?	12
Novel bis-benzimidazole-triazole hybrids: anticancer study, in silico approaches, and mechanistic investigation	12
Treating Neurodegenerative Diseases with Multitarget Drugs: An Interview With Maria João Matos	12
Rapid structure-based Identification of Potential SARS-CoV-2 Main Protease Inhibitors	12
Piperazine-1,2,3-triazole Scaffolds: design, synthesis, Anticancer and Antimicrobial Evaluation	12
Palbociclib-derived multifunctional molecules for lysosomal targeting and diagnostic-therapeutic integration	12
Novel Effective Small-Molecule Inhibitors of Protein Kinases Related to Tau Pathology in Alzheimer's Disease	11
Proteolysis Targeting Chimeras in Antiviral Research	11
Explainable Machine Learning for Medicinal Chemistry: Exploring Multi-Target Compounds	11
Synthesis of Novel Furan-Based Chalcone Derivatives As Anti-Tuberculosis Agents: In Vitro , Cytotoxicity Assessment and In Silico	11
E3 Ligases: a Potential Multi-Drug Target for Different Types of Cancers and Neurological Disorders	11
Synovial Mesenchymal Stem Cell-Derived Exosomal miR-320c Enhances Chondrogenesis By Targeting ADAM19	11
Targeted small molecule therapy and inhibitors for lymphoma	10
Advances of Biphenyl Small-Molecule Inhibitors Targeting PD-1/PD-L1 Interaction in Cancer Immunotherapy	10
Novel 2-Indolinone Derivatives as Promising Agents against Respiratory Syncytial and Yellow Fever Viruses	10
NeuroClick: Software for Mimicking Click Reaction to Generate Drug-Like Molecules Permeating the Blood–Brain Barrier	10
Synthesis and Characterization of Potent RIPK3 Inhibitors Based on a Tricyclic Scaffold	10
Design, Synthesis and Bio-Evaluation of Indolin-2-Ones As Potential Antidiabetic Agents	10
Refinement of MEK inhibitors	10
Design, Synthesis and Biological Evaluation of Novel Selective PI3Kδ Inhibitors Containing Pyridopyrimidine Scaffold	10
Selenium: The Emerging Element in the Medicinal Chemist’s Toolkit	10
Levamisole Derivatives As Immune Modulators for the Treatment of Amyotrophic Lateral Sclerosis (ALS)	10

In vitro anti-breast cancer study of hybrid cinnamic acid derivatives bearing 2-thiohydantoin moiety	10
New Indole Derivatives As Multitarget anti-Alzheimer's Agents: synthesis, Biological Evaluation and Molecular Dynamics	9
19 Schiff Bases as Antimycobacterial Agents: Synthesis, Molecular Docking and a Plausible Mechanism of Action	9
New Theobromine Derivatives Inhibiting VEGFR-2: Design, Synthesis, Antiproliferative, Docking and Molecular Dynamics Simulations	9
Novel Carbonic Anhydrase Inhibitors	9
One-pot synthesis and pharmacological evaluation of new quinoline/pyrimido-diazepines as pulmonary antifibrotic agents	9
Transition metal complexes: next-generation photosensitizers for combating Gram-positive bacteria	9
Novel Benzochromenes: Design, Synthesis, Cytotoxicity, Molecular Docking and Mechanistic Investigations	9
Novel Diamides Inspired By Protein Kinase Inhibitors As Anti- Trypanosoma Cruzi Agents: In Vitro and In Vivo	8
Candesartan, Losartan and Valsartan Zn(II) Complexes Interactions With Bovine Serum Albumin	8
Dorzolamide Suppresses PKCδ -TIRAP-p38 MAPK Signaling Axis to Dampen the Inflammatory Response	8
BioPrint Meets the AI Age: Development of Artificial Intelligence-Based ADMET Models for the Drug-Discovery Platform SAFIRE	8
From clove oil to bioactive agents: synthetic routes, antimicrobial and antiparasitic activities of eugenol derivatives	8
Mucin Glycosylation: A Potential Target for Prostate Cancer Management	8
Thiazolidinedione–Triazole Conjugates: Design, Synthesis and Probing of the α-Amylase Inhibitory Potential	8
Clinical Progress of KRAS-targeted Therapies: What next?	8
Synthesis and antiproliferative evaluation of novel 3,5,8-trisubstituted coumarins against breast cancer	7
COVID-19 Diagnostic Assay Sensitivity: Lessons for the Upcoming Wave Or Next Pandemic	7
Design, synthesis and mechanistic exploration of anti-plasmodial Indolo[2,3- b ]quinoxaline-7-chloroquinoline hybrids	7
New thiazolidin-4-ones as anti-cervical cancer agents targeting EGFR: design, synthesis, and computational studies	7
Recent Advances of Cannabidiol Studies in Medicinal chemistry, Pharmacology and Therapeutics	7
Development of indole hybrids for potential lung cancer treatment-part I: nitrogen-containing six-membered aromatic heterocycles	7
Ultrasonic-assisted synthesis and antitumor evaluation of novel variant heterocyclic compounds based on piperidine ring	7
Proteolysis-Targeting Chimera Molecules Targeting SHP2	7
Molecular Glues Targeting Protein Degradation Pathways for Drug Discovery	7
Organoselenium compounds beyond antioxidants	7
Novel Pyrimidine-1,3,4-Oxadiazole Hybrids and Their Precursors As Potential Antimycobacterial Agents	7
In-vitro and in-silico assessment of thiazole-thiazolidinone derivatives as selective inhibitors of urease and α-glucosidase	7
Welcome to the 16th Volume of Future Medicinal Chemistry	7
Design and Identification of Two Novel Resveratrol Derivatives As Potential LSD1 Inhibitors	7
Advancement of Targeted Protein Degradation Strategies As Therapeutics for Undruggable Disease Targets	7
Kynomycin: A Beacon of Hope in the Battle Against Antibiotic Resistance	7
Synthesis of Hydrazinylthiazole Carboxylates: A Mechanistic Approach for Treatment of Diabetes and Its Complications	7
The anticancer therapeutic potential of pyrimidine–sulfonamide hybrids	7
The emerging field of senotherapeutic drugs	6
Network Analysis and Ligand-Based Pharmacophore Modeling for Discovery of Small Molecule Against Glioblastoma Multiforme	6
Dual VEGFR-2 and EGFR T790M inhibitors of phenyldiazenes: anticancer evaluations, ADMET, docking, design and synthesis	6
Novel coumarin linked pyrazoles, thiazoles, and thiadiazoles: synthetic strategies and in vitro antimicrobial investigation	6
Virtual and Augmented Reality Applications in Medicinal Chemistry	6
The antibreast cancer therapeutic potential of quinazoline hybrids–Part I	6
Cyclin-Dependent Kinases As Potential Targets for Colorectal Cancer: Past, Present and Future	6
Research Progress on Tamoxifen and Its Analogs Associated With Nuclear Receptors	6
CK1 Delta Inhibition: An Emerging Strategy to Combat Neurodegenerative Diseases	6
Design and Synthesis of Selective FLT3 Inhibitors Via Exploration of Back Pocket II	6
Evidence-based drug discovery	6
Antimicrobial, Anticancer and Immunomodulatory Potential of New Quinazolines Bearing Benzenesulfonamide Moiety	6
Design, Synthesis and Anticancer Evaluation of Some Novel 7-Hydroxy-4-Methyl-3-Substituted Benzopyran-2-One Derivatives	6
Pyrazine-based small molecule kinase inhibitors: clinical applications and patent review (2019–2023)	6
Novel 4-Aminoquinoline Analogs Targeting the HIF-1α Signaling Pathway	6
Benzimidazole-acrylonitrile hybrid derivatives act as potent urease inhibitors with possible fungicidal activity	6
Optimizing selective estrogen receptor degraders for anticancer drug development	6
Corrigendum	6
Synthesis, characterization and biological evaluation of aurones as potential neuroprotective agents	6
Development of Small Macrocyclic Kinase Inhibitors	6
Establishment of Models for Reliability Evaluation of 3CLpro Ligand-Receptor Complexes With Different Binding Sites	6
Unveiling the potential of HS-1793: a review of its anticancer properties and therapeutic promise	5
Designing molecular hybrids as novel breast cancer therapeutics	5
Human Sirtuin 2 inhibitors, Their Mechanisms and Binding Modes	5
Expanding potential of quinoline hydrazide/hydrazone derivatives as anticancer agents	5
Innovative virtual screening of PD-L1 inhibitors: the synergy of molecular similarity, neural networks and GNINA docking	5
Resistant Starch: Ideal Candidate for the Enteric Coating of NSAIDs?	5
Synthesis, cytotoxicity and 99m Tc-MIBI tumor cell uptake evaluation of 2-phenylbenzothiazole tagged triazole derivatives	5
Design, Synthesis and Structure–Activity Relationship Studies of Novel Spirochromanone Hydrochloride Analogs As Anticancer Agents	5
Development of indole hybrids for potential lung cancer treatment - part II	5
Semicarbazone, thiosemicarbazone tailed isoxazoline-pyrazole: synthesis, DFT, biological and computational assessment	5
Enoxacin-Based Derivatives: Antimicrobial and Antibiofilm Agent: A Biology-Oriented Drug Synthesis (BIODS) Approach	5
A novel class of potent antiangiogenic and antioxidant pyrazoles: synthesis, bioactivity, docking and ADMET studies	5
Therapeutic targeting of neuroinflammation in methamphetamine use disorder	5
Salvianolic Acid B Noncovalently Interacts With Disordered c-Myc: A Computational and Spectroscopic-Based Study	5
Synthesis and Anti-Ovarian Cancer Effects of Benzimidazole-2-Substituted Pyridine and Phenyl Propenone Derivatives	5
Tetrahydroquinoline: An Efficient Scaffold As mTOR Inhibitor for the Treatment of Lung Cancer	5
Glyco Disulfide Capped Gold Nanoparticle Synthesis: Cytotoxicity Studies and Effects on Lung Cancer A549 Cells	5
Sirtuin Modulators: Past, Present, and Future Perspectives	5
Prioritizing oral bioavailability in drug development strategies	5
Parasitic Sirtuin 2 As an Opportunity in Drug Discovery	5
Targeting STK33: From Inhibition to Degradation	5
Challenging Breast Cancer Through Novel sulfonamide–pyridine Hybrids: design, synthesis, Carbonic Anhydrase IX Inhibition and Induction of Apoptosis	5
Key developments in fluorinated heterocycles	5
Benzo[ d ]thiazole-2-Carboxamides As New Antituberculosis Chemotypes Inhibiting Mycobacterial ATP Phosphoribosyl Transferase	5
Therapeutic potential of chalcone-1,2,3-triazole hybrids as anti-tumour agents: a systematic review and SAR studies	5

Gold: Not Just jewelry…	5
Combining Virtual Screening and In Vitro Evaluation for the Discovery of Potential CYP11B2 Inhibitors	5
Design, semi-synthesis and bioevaluation of koumine-like derivatives as potential antitumor agents in vitro and in vivo	5
Design and Synthesis of Novel Aza-Ursolic Acid Derivatives: In Vitro Cytotoxicity and Nitric Oxide Release Inhibitory Activity	5
Recent development of azole–sulfonamide hybrids with the anticancer potential	5
Our New Year's (re)solution: Welcome to the 15th Volume of Future Medicinal Chemistry	5