Future Medicinal Chemistry

Article	Citations
Sulfonamide-salicylaldehyde Imines Active Against methicillin- and trimethoprim/sulfonamide-resistant Staphylococci	58
Novel Set of Highly Substituted Bis-Pyridines: Synthesis, Molecular Docking and Drug-Resistant Antibacterial Profile	57
Super-Conserved Receptors Expressed in the Brain: Biology and Medicinal Chemistry Efforts	57
In vivo evaluation of novel synthetic pyrazolones as CDK9 inhibitors with enhanced pharmacokinetic properties	52
Design of SARS-CoV-2 Mpro, PLpro Dual-Target Inhibitors Based on Deep Reinforcement Learning and Virtual Screening	51
Biological and computational evaluation of novel benzofuranyl derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors	44
Combining EGFR Inhibitors With SHP2 Or LSD1 Inhibitors to Overcome Multidrug Resistance in Cancer	44
Identification of Sulfonamide-Based Butyrylcholinesterase Inhibitors Using Machine Learning	42
Citrate Transporter Inhibitors: Possible New Anticancer Agents	40
Therapeutic N -Heterocyclic Carbenes: An Interview With Alejandro Bugarin	39
The Connection Between PARP14 and SARS-CoV-2	38
Targeting Tuberculosis – An Interview With Robert Abramovitch	36
Selection of SARS-CoV-2 Main Protease Inhibitor Using Structure-Based Virtual Screening	34
Development of 5-hydroxybenzothiophene derivatives as multi-kinase inhibitors with potential anti-cancer activity	34
Investigations of New N 1 -Substituted Pyrazoles as Anti-Inflammatory and Analgesic Agents having COX Inhibitory Act	31
Combining Structure-Based and 3D QSAR Pharmacophore Models to Discover Diverse Ligands Against EGFR in Oral Cancer	28
5,7,3′,4′-Tetramethoxyflavone Ameliorates Cholesterol Dysregulation by Mediating SIRT1/FOXO3a/ABCA1 Signaling in Osteoarthritis Chondrocytes	28
Design and synthesis of new nicotinamides as immunomodulatory VEGFR-2 inhibitors and apoptosis inducers	28
Barbiturate–sulfonate hybrids as potent cholinesterase inhibitors: design, synthesis and molecular modeling studies	27
HDAC8 As an Emerging Target in Drug Discovery With Special Emphasis on Medicinal Chemistry	26
Rh(III) and Ru(II) Complexes With Phosphanyl–Alkylamines: Inhibition of DNA Synthesis Induced By Anticancer Rh Complex	23
Synergistic effect of new pyrimidine derivative with oxacilin against methicillin-resistant Staphylococcus aureus	23
Advances in AR-Targeting Chimeras: A Case Study of proteolysis-targeting Chimeras From Bench to Bedside	22
Design, synthesis and inhibition evaluation of novel chalcone amide α-glucosidase inhibitors	22
Computational Insights Into Novel Inhibitor Indole-Heterocycle Specific Against Glycogen Phosphorylase Isoenzymes Interaction Mechanism	22

Synthesis, in vitro and in silico anticancer evaluation of novel pyridin-2-yl estra-1,3,5(10)-triene derivatives	21
Diaminomaleonitrile Derivatives as new Potential Antichagasic Compounds: A Study of Structure–Activity Relationships	20
Discovery of Novel Covalent Inhibitors of DJ-1 Through Hybrid Virtual Screening	20
Propargylamine: an Important Moiety in Drug Discovery	20
Novel Xylenyl-Spaced Bis-Thiazoles/Thiazines: Synthesis, Biological Profile as Herpes Simplex Virus Type 1 Inhibitors and in Silico Simulations	19
Synthesis of Hydrazinyl–Thiazole Ester Derivatives, in Vitro Trypanocidal and Leishmanicidal Activities	18
Basic nitrogen (BaN): a ‘privileged element’ in medicinal chemistry	18
New pyrrolopyridine-based Thiazolotriazoles As Diabetics Inhibitors: Enzymatic Kinetics and In Silico Study	18
Synthesis, antimicrobial evaluation, HPLC-based compound accumulation and docking studies of 2-methoxybenzoyl thioureas	18
γ-Secretase As a Drug Target for Familial Alzheimer's Disease: The Road Less Traveled	17
Unlocking the power of imidazoquinolines: recent advances in anticancer and immunotherapeutic strategies	17
Management of Adenocarcinoma With Honokiol: Progress So Far and the Way Forward	17
Keto-Bridged Dual Triazole-Linked Benzenesulfonamides As Potent Carbonic Anhydrase and Cathepsin B Inhibitors	17
Recent Advancements in the Discovery of Cereblon-Based Protease-Targeted Chimeras With Potential for Therapeutic Intervention	16
Medicinal Chemistry in Big Pharma has a Gender Diversity Problem	16
Potent α-glucosidase inhibitors with benzimidazole-propionitrile hybridization; synthesis, bioassay and docking study	16
Computational Repurposing of Benzimidazole Anthelmintic Drugs As Potential Colchicine Binding Site Inhibitors	15
HIV-1 Capsid Inhibitors: A Sword to Destroy the Virus	15
Machine Learning and Deep Learning in Data-Driven Decision Making of Drug Discovery and Challenges in High-Quality Data Acquisition in the Pharmaceutical Industry	15
GANT61 Elevates Chemosensitivity to Cisplatin Through Regulating the Hedgehog, AMPK and cAMP Pathways in Ovarian Cancer	15
Autophagy degradation: a promising dimension in drug discovery for neurodegenerative diseases	14
The versatility of phenothiazines as an anticancer drug scaffold	14
Targeting TGF-β: Triumphs and Challenges	14
How does machine learning augment alchemical binding free energy calculations?	14
Copper(II) complexes of 2-hydroxy-1-naphthaldehyde Schiff bases: synthesis, in vitro activity and computational studies	14
Latest developments in photosensitizers: improving stability, specificity and responsiveness	13
Synthesis of indole-functionalized isoniazid conjugates with potent antimycobacterial and antioxidant efficacy	13
Synovial Mesenchymal Stem Cell-Derived Exosomal miR-320c Enhances Chondrogenesis By Targeting ADAM19	13
E3 Ligases: a Potential Multi-Drug Target for Different Types of Cancers and Neurological Disorders	13
Design, Synthesis and Antitumor Activity of Novel pyran-functionalized Uracil Derivatives: Docking Studies	13
Proteolysis Targeting Chimeras in Antiviral Research	13
Synthesis of Novel Furan-Based Chalcone Derivatives As Anti-Tuberculosis Agents: In Vitro , Cytotoxicity Assessment and In Silico	13
Novel bis-benzimidazole-triazole hybrids: anticancer study, in silico approaches, and mechanistic investigation	13
Palbociclib-derived multifunctional molecules for lysosomal targeting and diagnostic-therapeutic integration	13
NeuroClick: Software for Mimicking Click Reaction to Generate Drug-Like Molecules Permeating the Blood–Brain Barrier	12
Piperazine-1,2,3-triazole Scaffolds: design, synthesis, Anticancer and Antimicrobial Evaluation	12
Novel Effective Small-Molecule Inhibitors of Protein Kinases Related to Tau Pathology in Alzheimer's Disease	12
Synthesis and Characterization of Potent RIPK3 Inhibitors Based on a Tricyclic Scaffold	12
Treating Neurodegenerative Diseases with Multitarget Drugs: An Interview With Maria João Matos	12
Recent advances in the investigation of the quinazoline nucleus and derivatives with potential anticancer activities	11
The current landscape of indole hybrids with in vivo antitumor potential	11
New Indole Derivatives As Multitarget anti-Alzheimer's Agents: synthesis, Biological Evaluation and Molecular Dynamics	11
New Theobromine Derivatives Inhibiting VEGFR-2: Design, Synthesis, Antiproliferative, Docking and Molecular Dynamics Simulations	11
Levamisole Derivatives As Immune Modulators for the Treatment of Amyotrophic Lateral Sclerosis (ALS)	10
Explainable Machine Learning for Medicinal Chemistry: Exploring Multi-Target Compounds	10
19 Schiff Bases as Antimycobacterial Agents: Synthesis, Molecular Docking and a Plausible Mechanism of Action	10
Design, Synthesis and Bio-Evaluation of Indolin-2-Ones As Potential Antidiabetic Agents	10
Refinement of MEK inhibitors	10
Design, Synthesis and Biological Evaluation of Novel Selective PI3Kδ Inhibitors Containing Pyridopyrimidine Scaffold	10
Novel Benzochromenes: Design, Synthesis, Cytotoxicity, Molecular Docking and Mechanistic Investigations	9

Novel Carbonic Anhydrase Inhibitors	9
Advances of Biphenyl Small-Molecule Inhibitors Targeting PD-1/PD-L1 Interaction in Cancer Immunotherapy	9
Selenium: The Emerging Element in the Medicinal Chemist’s Toolkit	9
Novel 2-Indolinone Derivatives as Promising Agents against Respiratory Syncytial and Yellow Fever Viruses	9
In vitro anti-breast cancer study of hybrid cinnamic acid derivatives bearing 2-thiohydantoin moiety	9
One-pot synthesis and pharmacological evaluation of new quinoline/pyrimido-diazepines as pulmonary antifibrotic agents	9
Mucin Glycosylation: A Potential Target for Prostate Cancer Management	8
Novel Pyrimidine-1,3,4-Oxadiazole Hybrids and Their Precursors As Potential Antimycobacterial Agents	8
Candesartan, Losartan and Valsartan Zn(II) Complexes Interactions With Bovine Serum Albumin	8
Transition metal complexes: next-generation photosensitizers for combating Gram-positive bacteria	8
Development of indole hybrids for potential lung cancer treatment-part I: nitrogen-containing six-membered aromatic heterocycles	8
Molecular Glues Targeting Protein Degradation Pathways for Drug Discovery	8
Targeted small molecule therapy and inhibitors for lymphoma	8
Novel Diamides Inspired By Protein Kinase Inhibitors As Anti- Trypanosoma Cruzi Agents: In Vitro and In Vivo	8
Clinical Progress of KRAS-targeted Therapies: What next?	8
The emerging field of senotherapeutic drugs	7
From clove oil to bioactive agents: synthetic routes, antimicrobial and antiparasitic activities of eugenol derivatives	7
Thiazolidinedione–Triazole Conjugates: Design, Synthesis and Probing of the α-Amylase Inhibitory Potential	7
BioPrint Meets the AI Age: Development of Artificial Intelligence-Based ADMET Models for the Drug-Discovery Platform SAFIRE	7
Design, synthesis and mechanistic exploration of anti-plasmodial Indolo[2,3- b ]quinoxaline-7-chloroquinoline hybrids	7
Benzimidazole-acrylonitrile hybrid derivatives act as potent urease inhibitors with possible fungicidal activity	7
COVID-19 Diagnostic Assay Sensitivity: Lessons for the Upcoming Wave Or Next Pandemic	7
Design and Synthesis of Selective FLT3 Inhibitors Via Exploration of Back Pocket II	7
Optimizing selective estrogen receptor degraders for anticancer drug development	7
Advancement of Targeted Protein Degradation Strategies As Therapeutics for Undruggable Disease Targets	7
Dorzolamide Suppresses PKCδ -TIRAP-p38 MAPK Signaling Axis to Dampen the Inflammatory Response	7
Recent Advances of Cannabidiol Studies in Medicinal chemistry, Pharmacology and Therapeutics	7
Kynomycin: A Beacon of Hope in the Battle Against Antibiotic Resistance	7
Synthesis of Hydrazinylthiazole Carboxylates: A Mechanistic Approach for Treatment of Diabetes and Its Complications	7
Research Progress on Tamoxifen and Its Analogs Associated With Nuclear Receptors	7
Network Analysis and Ligand-Based Pharmacophore Modeling for Discovery of Small Molecule Against Glioblastoma Multiforme	7
Novel coumarin linked pyrazoles, thiazoles, and thiadiazoles: synthetic strategies and in vitro antimicrobial investigation	7
CK1 Delta Inhibition: An Emerging Strategy to Combat Neurodegenerative Diseases	7
Recent Advances in dehydroacetic acid-clubbed pyridine conjugates: design, synthesis, characterization, molecular docking investigations and evaluation of anti-cancer efficacy	7
New thiazolidin-4-ones as anti-cervical cancer agents targeting EGFR: design, synthesis, and computational studies	7
In-vitro and in-silico assessment of thiazole-thiazolidinone derivatives as selective inhibitors of urease and α-glucosidase	7
Organoselenium compounds beyond antioxidants	7
Novel 4-Aminoquinoline Analogs Targeting the HIF-1α Signaling Pathway	7
The antibreast cancer therapeutic potential of quinazoline hybrids–Part I	7
Corrigendum	7
Welcome to the 16th Volume of Future Medicinal Chemistry	7
Design, Synthesis and Anticancer Evaluation of Some Novel 7-Hydroxy-4-Methyl-3-Substituted Benzopyran-2-One Derivatives	6
Therapeutic potential of chalcone-1,2,3-triazole hybrids as anti-tumour agents: a systematic review and SAR studies	6
Coumarin hybrids: dual-target candidates for future antimicrobial and antitubercular therapies	6
Synthesis and Anti-Ovarian Cancer Effects of Benzimidazole-2-Substituted Pyridine and Phenyl Propenone Derivatives	6
Dual VEGFR-2 and EGFR T790M inhibitors of phenyldiazenes: anticancer evaluations, ADMET, docking, design and synthesis	6
Development of Small Macrocyclic Kinase Inhibitors	6
Key developments in fluorinated heterocycles	6
Designing molecular hybrids as novel breast cancer therapeutics	6
Our New Year's (re)solution: Welcome to the 15th Volume of Future Medicinal Chemistry	6
Challenging Breast Cancer Through Novel sulfonamide–pyridine Hybrids: design, synthesis, Carbonic Anhydrase IX Inhibition and Induction of Apoptosis	6
Recent developments in matrine as a versatile molecular scaffold in small molecule drug discovery	6
Expanding potential of quinoline hydrazide/hydrazone derivatives as anticancer agents	6
Synthesis, characterization and biological evaluation of aurones as potential neuroprotective agents	6
Ultrasonic-assisted synthesis and antitumor evaluation of novel variant heterocyclic compounds based on piperidine ring	6
Antimicrobial, Anticancer and Immunomodulatory Potential of New Quinazolines Bearing Benzenesulfonamide Moiety	6
Pyrazine-based small molecule kinase inhibitors: clinical applications and patent review (2019–2023)	6
Virtual and Augmented Reality Applications in Medicinal Chemistry	6
Human Sirtuin 2 inhibitors, Their Mechanisms and Binding Modes	6
Establishment of Models for Reliability Evaluation of 3CLpro Ligand-Receptor Complexes With Different Binding Sites	6
Design and synthesis of newer 5-aryl- N -(naphthalen-2-yl)-1,3,4-oxadiazol-2-amine analogues as anticancer agents	6
Tetrahydroquinoline: An Efficient Scaffold As mTOR Inhibitor for the Treatment of Lung Cancer	6
Benzo[ d ]thiazole-2-Carboxamides As New Antituberculosis Chemotypes Inhibiting Mycobacterial ATP Phosphoribosyl Transferase	6
Evidence-based drug discovery	6
Proteolysis-Targeting Chimera Molecules Targeting SHP2	6
Synthesis and antiproliferative evaluation of novel 3,5,8-trisubstituted coumarins against breast cancer	6
The anticancer therapeutic potential of pyrimidine–sulfonamide hybrids	6
Therapeutic targeting of neuroinflammation in methamphetamine use disorder	6
Cyclin-Dependent Kinases As Potential Targets for Colorectal Cancer: Past, Present and Future	6
Advances in Research With Rutin-Loaded Nanoformulations in Mitigating Lung Diseases	5
Conjugated Carbon Monoxide-Releasing Molecules have Broad-Spectrum Antimicrobial Activity	5
Recent advances in targeted degradation in the RAS pathway	5
Synthesis, cytotoxicity and 99m Tc-MIBI tumor cell uptake evaluation of 2-phenylbenzothiazole tagged triazole derivatives	5
Gold: Not Just jewelry…	5
A novel class of potent antiangiogenic and antioxidant pyrazoles: synthesis, bioactivity, docking and ADMET studies	5
Combining Virtual Screening and In Vitro Evaluation for the Discovery of Potential CYP11B2 Inhibitors	5
Prioritizing oral bioavailability in drug development strategies	5
Innovative virtual screening of PD-L1 inhibitors: the synergy of molecular similarity, neural networks and GNINA docking	5
Recent development of azole–sulfonamide hybrids with the anticancer potential	5
Novel Sulfonamide Derivatives as a Tool to Combat Methicillin-Resistant Staphylococcus Aureus	5

Environment benign synthesis of 5-acyl-4-hydroxypyridin-2(1 H )-one derivatives as antioxidant and α -amylase inhibitors	5
Exploring the therapeutic potential and chemical properties of trans-chalcone: a comprehensive review	5
Design, synthesis, and molecular docking studies of thiazole derivatives against phospholipase A 2 ( Naja oxiana ) venom	5
Glyco Disulfide Capped Gold Nanoparticle Synthesis: Cytotoxicity Studies and Effects on Lung Cancer A549 Cells	5
Semicarbazone, thiosemicarbazone tailed isoxazoline-pyrazole: synthesis, DFT, biological and computational assessment	5
Development of indole hybrids for potential lung cancer treatment - part II	5
Design and Synthesis of Novel Aza-Ursolic Acid Derivatives: In Vitro Cytotoxicity and Nitric Oxide Release Inhibitory Activity	5
Design, semi-synthesis and bioevaluation of koumine-like derivatives as potential antitumor agents in vitro and in vivo	5
Sirtuin Modulators: Past, Present, and Future Perspectives	5
Recent Progress of Palmitoyl Transferase DHHC3 As a Novel Antitumor Target	5
New and potential boron-containing compounds for treatment of Alzheimer's disease and cancers	5
Regulation of post-translational modification of PD-L1 and associated opportunities for novel small-molecule therapeutics	5
Urea-sugar and thiourea-sugar diastereomers: synthesis, crystal structure and biological activities	5
Enoxacin-Based Derivatives: Antimicrobial and Antibiofilm Agent: A Biology-Oriented Drug Synthesis (BIODS) Approach	5
Design, Synthesis and Structure–Activity Relationship Studies of Novel Spirochromanone Hydrochloride Analogs As Anticancer Agents	5
Targeting STK33: From Inhibition to Degradation	5
Unveiling the potential of HS-1793: a review of its anticancer properties and therapeutic promise	5