Future Medicinal Chemistry

Article	Citations
In vivo evaluation of novel synthetic pyrazolones as CDK9 inhibitors with enhanced pharmacokinetic properties	57
Sulfonamide-salicylaldehyde Imines Active Against methicillin- and trimethoprim/sulfonamide-resistant Staphylococci	52
Design of SARS-CoV-2 Mpro, PLpro Dual-Target Inhibitors Based on Deep Reinforcement Learning and Virtual Screening	47
Combining EGFR Inhibitors With SHP2 Or LSD1 Inhibitors to Overcome Multidrug Resistance in Cancer	45
Design and synthesis of new nicotinamides as immunomodulatory VEGFR-2 inhibitors and apoptosis inducers	45
Biological and computational evaluation of novel benzofuranyl derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors	39
Citrate Transporter Inhibitors: Possible New Anticancer Agents	38
Identification of Sulfonamide-Based Butyrylcholinesterase Inhibitors Using Machine Learning	38
Therapeutic N -Heterocyclic Carbenes: An Interview With Alejandro Bugarin	37
Novel Set of Highly Substituted Bis-Pyridines: Synthesis, Molecular Docking and Drug-Resistant Antibacterial Profile	37
The Connection Between PARP14 and SARS-CoV-2	35
Super-Conserved Receptors Expressed in the Brain: Biology and Medicinal Chemistry Efforts	31
A Review of Current and Promising Nontuberculous Mycobacteria Antibiotics	28
Selection of SARS-CoV-2 Main Protease Inhibitor Using Structure-Based Virtual Screening	28
Targeting Tuberculosis – An Interview With Robert Abramovitch	28
Investigations of New N 1 -Substituted Pyrazoles as Anti-Inflammatory and Analgesic Agents having COX Inhibitory Act	27
Development of 5-hydroxybenzothiophene derivatives as multi-kinase inhibitors with potential anti-cancer activity	27
Combining Structure-Based and 3D QSAR Pharmacophore Models to Discover Diverse Ligands Against EGFR in Oral Cancer	27
5,7,3′,4′-Tetramethoxyflavone Ameliorates Cholesterol Dysregulation by Mediating SIRT1/FOXO3a/ABCA1 Signaling in Osteoarthritis Chondrocytes	26
Synthesis of Hydrazinyl–Thiazole Ester Derivatives, in Vitro Trypanocidal and Leishmanicidal Activities	24
Synergistic effect of new pyrimidine derivative with oxacilin against methicillin-resistant Staphylococcus aureus	22
Rh(III) and Ru(II) Complexes With Phosphanyl–Alkylamines: Inhibition of DNA Synthesis Induced By Anticancer Rh Complex	22
Computational Insights Into Novel Inhibitor Indole-Heterocycle Specific Against Glycogen Phosphorylase Isoenzymes Interaction Mechanism	21
HDAC8 As an Emerging Target in Drug Discovery With Special Emphasis on Medicinal Chemistry	21
Basic nitrogen (BaN): a ‘privileged element’ in medicinal chemistry	21

Design, synthesis and inhibition evaluation of novel chalcone amide α-glucosidase inhibitors	20
A New Class of 5-HT 1A Receptor Antagonists With Procognitive and Antidepressant Properties	19
New pyrrolopyridine-based Thiazolotriazoles As Diabetics Inhibitors: Enzymatic Kinetics and In Silico Study	19
Diaminomaleonitrile Derivatives as new Potential Antichagasic Compounds: A Study of Structure–Activity Relationships	19
Advances in AR-Targeting Chimeras: A Case Study of proteolysis-targeting Chimeras From Bench to Bedside	18
Novel Xylenyl-Spaced Bis-Thiazoles/Thiazines: Synthesis, Biological Profile as Herpes Simplex Virus Type 1 Inhibitors and in Silico Simulations	18
Synthesis, in vitro and in silico anticancer evaluation of novel pyridin-2-yl estra-1,3,5(10)-triene derivatives	17
Propargylamine: an Important Moiety in Drug Discovery	16
Synthesis, antimicrobial evaluation, HPLC-based compound accumulation and docking studies of 2-methoxybenzoyl thioureas	16
Barbiturate–sulfonate hybrids as potent cholinesterase inhibitors: design, synthesis and molecular modeling studies	16
Discovery of Novel Covalent Inhibitors of DJ-1 Through Hybrid Virtual Screening	16
Unlocking the power of imidazoquinolines: recent advances in anticancer and immunotherapeutic strategies	15
Keto-Bridged Dual Triazole-Linked Benzenesulfonamides As Potent Carbonic Anhydrase and Cathepsin B Inhibitors	15
γ-Secretase As a Drug Target for Familial Alzheimer's Disease: The Road Less Traveled	14
GANT61 Elevates Chemosensitivity to Cisplatin Through Regulating the Hedgehog, AMPK and cAMP Pathways in Ovarian Cancer	14
Copper(II) complexes of 2-hydroxy-1-naphthaldehyde Schiff bases: synthesis, in vitro activity and computational studies	14
Management of Adenocarcinoma With Honokiol: Progress So Far and the Way Forward	14
Potent α-glucosidase inhibitors with benzimidazole-propionitrile hybridization; synthesis, bioassay and docking study	14
Recent Advancements in the Discovery of Cereblon-Based Protease-Targeted Chimeras With Potential for Therapeutic Intervention	13
Targeting TGF-β: Triumphs and Challenges	13
The versatility of phenothiazines as an anticancer drug scaffold	13
How does machine learning augment alchemical binding free energy calculations?	13
HIV-1 Capsid Inhibitors: A Sword to Destroy the Virus	13
Computational Repurposing of Benzimidazole Anthelmintic Drugs As Potential Colchicine Binding Site Inhibitors	13
Autophagy degradation: a promising dimension in drug discovery for neurodegenerative diseases	13
Synovial Mesenchymal Stem Cell-Derived Exosomal miR-320c Enhances Chondrogenesis By Targeting ADAM19	13
Medicinal Chemistry in Big Pharma has a Gender Diversity Problem	13
Machine Learning and Deep Learning in Data-Driven Decision Making of Drug Discovery and Challenges in High-Quality Data Acquisition in the Pharmaceutical Industry	13
Novel bis-benzimidazole-triazole hybrids: anticancer study, in silico approaches, and mechanistic investigation	13
Palbociclib-derived multifunctional molecules for lysosomal targeting and diagnostic-therapeutic integration	13
Treating Neurodegenerative Diseases with Multitarget Drugs: An Interview With Maria João Matos	12
E3 Ligases: a Potential Multi-Drug Target for Different Types of Cancers and Neurological Disorders	12
Piperazine-1,2,3-triazole Scaffolds: design, synthesis, Anticancer and Antimicrobial Evaluation	12
Proteolysis Targeting Chimeras in Antiviral Research	12
Synthesis of indole-functionalized isoniazid conjugates with potent antimycobacterial and antioxidant efficacy	12
Rapid structure-based Identification of Potential SARS-CoV-2 Main Protease Inhibitors	12
Synthesis of Novel Furan-Based Chalcone Derivatives As Anti-Tuberculosis Agents: In Vitro , Cytotoxicity Assessment and In Silico	12
Design, Synthesis and Antitumor Activity of Novel pyran-functionalized Uracil Derivatives: Docking Studies	12
Targeted small molecule therapy and inhibitors for lymphoma	11
Novel Effective Small-Molecule Inhibitors of Protein Kinases Related to Tau Pathology in Alzheimer's Disease	11
Advances of Biphenyl Small-Molecule Inhibitors Targeting PD-1/PD-L1 Interaction in Cancer Immunotherapy	11
NeuroClick: Software for Mimicking Click Reaction to Generate Drug-Like Molecules Permeating the Blood–Brain Barrier	11
Refinement of MEK inhibitors	10
Novel Carbonic Anhydrase Inhibitors	10
Synthesis and Characterization of Potent RIPK3 Inhibitors Based on a Tricyclic Scaffold	10
19 Schiff Bases as Antimycobacterial Agents: Synthesis, Molecular Docking and a Plausible Mechanism of Action	10
Explainable Machine Learning for Medicinal Chemistry: Exploring Multi-Target Compounds	10
Selenium: The Emerging Element in the Medicinal Chemist’s Toolkit	10
Levamisole Derivatives As Immune Modulators for the Treatment of Amyotrophic Lateral Sclerosis (ALS)	10
Design, Synthesis and Bio-Evaluation of Indolin-2-Ones As Potential Antidiabetic Agents	10

New Indole Derivatives As Multitarget anti-Alzheimer's Agents: synthesis, Biological Evaluation and Molecular Dynamics	9
In vitro anti-breast cancer study of hybrid cinnamic acid derivatives bearing 2-thiohydantoin moiety	9
Design, Synthesis and Biological Evaluation of Novel Selective PI3Kδ Inhibitors Containing Pyridopyrimidine Scaffold	9
Recent advances in the investigation of the quinazoline nucleus and derivatives with potential anticancer activities	9
Novel Benzochromenes: Design, Synthesis, Cytotoxicity, Molecular Docking and Mechanistic Investigations	9
New Theobromine Derivatives Inhibiting VEGFR-2: Design, Synthesis, Antiproliferative, Docking and Molecular Dynamics Simulations	9
Transition metal complexes: next-generation photosensitizers for combating Gram-positive bacteria	9
Novel 2-Indolinone Derivatives as Promising Agents against Respiratory Syncytial and Yellow Fever Viruses	9
One-pot synthesis and pharmacological evaluation of new quinoline/pyrimido-diazepines as pulmonary antifibrotic agents	9
Novel Diamides Inspired By Protein Kinase Inhibitors As Anti- Trypanosoma Cruzi Agents: In Vitro and In Vivo	9
Dorzolamide Suppresses PKCδ -TIRAP-p38 MAPK Signaling Axis to Dampen the Inflammatory Response	8
Molecular Glues Targeting Protein Degradation Pathways for Drug Discovery	8
Mucin Glycosylation: A Potential Target for Prostate Cancer Management	8
New thiazolidin-4-ones as anti-cervical cancer agents targeting EGFR: design, synthesis, and computational studies	8
Clinical Progress of KRAS-targeted Therapies: What next?	8
From clove oil to bioactive agents: synthetic routes, antimicrobial and antiparasitic activities of eugenol derivatives	8
Candesartan, Losartan and Valsartan Zn(II) Complexes Interactions With Bovine Serum Albumin	8
Organoselenium compounds beyond antioxidants	7
BioPrint Meets the AI Age: Development of Artificial Intelligence-Based ADMET Models for the Drug-Discovery Platform SAFIRE	7
Development of indole hybrids for potential lung cancer treatment-part I: nitrogen-containing six-membered aromatic heterocycles	7
Novel Pyrimidine-1,3,4-Oxadiazole Hybrids and Their Precursors As Potential Antimycobacterial Agents	7
Proteolysis-Targeting Chimera Molecules Targeting SHP2	7
CK1 Delta Inhibition: An Emerging Strategy to Combat Neurodegenerative Diseases	7
Novel coumarin linked pyrazoles, thiazoles, and thiadiazoles: synthetic strategies and in vitro antimicrobial investigation	7
Synthesis, characterization and biological evaluation of aurones as potential neuroprotective agents	7
In-vitro and in-silico assessment of thiazole-thiazolidinone derivatives as selective inhibitors of urease and α-glucosidase	7
Kynomycin: A Beacon of Hope in the Battle Against Antibiotic Resistance	7
Design and Identification of Two Novel Resveratrol Derivatives As Potential LSD1 Inhibitors	7
Synthesis of Hydrazinylthiazole Carboxylates: A Mechanistic Approach for Treatment of Diabetes and Its Complications	7
Research Progress on Tamoxifen and Its Analogs Associated With Nuclear Receptors	7
Optimizing selective estrogen receptor degraders for anticancer drug development	7
The emerging field of senotherapeutic drugs	7
Novel 4-Aminoquinoline Analogs Targeting the HIF-1α Signaling Pathway	7
Thiazolidinedione–Triazole Conjugates: Design, Synthesis and Probing of the α-Amylase Inhibitory Potential	7
Advancement of Targeted Protein Degradation Strategies As Therapeutics for Undruggable Disease Targets	7
Design, synthesis and mechanistic exploration of anti-plasmodial Indolo[2,3- b ]quinoxaline-7-chloroquinoline hybrids	7
Recent Advances of Cannabidiol Studies in Medicinal chemistry, Pharmacology and Therapeutics	7
Benzimidazole-acrylonitrile hybrid derivatives act as potent urease inhibitors with possible fungicidal activity	7
Welcome to the 16th Volume of Future Medicinal Chemistry	7
Corrigendum	7
Cyclin-Dependent Kinases As Potential Targets for Colorectal Cancer: Past, Present and Future	6
Expanding potential of quinoline hydrazide/hydrazone derivatives as anticancer agents	6
Pyrazine-based small molecule kinase inhibitors: clinical applications and patent review (2019–2023)	6
The anticancer therapeutic potential of pyrimidine–sulfonamide hybrids	6
Network Analysis and Ligand-Based Pharmacophore Modeling for Discovery of Small Molecule Against Glioblastoma Multiforme	6
Dual VEGFR-2 and EGFR T790M inhibitors of phenyldiazenes: anticancer evaluations, ADMET, docking, design and synthesis	6
Antimicrobial, Anticancer and Immunomodulatory Potential of New Quinazolines Bearing Benzenesulfonamide Moiety	6
Establishment of Models for Reliability Evaluation of 3CLpro Ligand-Receptor Complexes With Different Binding Sites	6
Coumarin hybrids: dual-target candidates for future antimicrobial and antitubercular therapies	6
Designing molecular hybrids as novel breast cancer therapeutics	6
Benzo[ d ]thiazole-2-Carboxamides As New Antituberculosis Chemotypes Inhibiting Mycobacterial ATP Phosphoribosyl Transferase	6
Development of Small Macrocyclic Kinase Inhibitors	6
COVID-19 Diagnostic Assay Sensitivity: Lessons for the Upcoming Wave Or Next Pandemic	6
Ultrasonic-assisted synthesis and antitumor evaluation of novel variant heterocyclic compounds based on piperidine ring	6
Virtual and Augmented Reality Applications in Medicinal Chemistry	6
Salvianolic Acid B Noncovalently Interacts With Disordered c-Myc: A Computational and Spectroscopic-Based Study	6
Resistant Starch: Ideal Candidate for the Enteric Coating of NSAIDs?	6
Design and synthesis of newer 5-aryl- N -(naphthalen-2-yl)-1,3,4-oxadiazol-2-amine analogues as anticancer agents	6
Key developments in fluorinated heterocycles	6
Tetrahydroquinoline: An Efficient Scaffold As mTOR Inhibitor for the Treatment of Lung Cancer	6
The antibreast cancer therapeutic potential of quinazoline hybrids–Part I	6
Synthesis and antiproliferative evaluation of novel 3,5,8-trisubstituted coumarins against breast cancer	6
Design and Synthesis of Selective FLT3 Inhibitors Via Exploration of Back Pocket II	6
Evidence-based drug discovery	6
Therapeutic potential of chalcone-1,2,3-triazole hybrids as anti-tumour agents: a systematic review and SAR studies	6
Synthesis and Anti-Ovarian Cancer Effects of Benzimidazole-2-Substituted Pyridine and Phenyl Propenone Derivatives	6
Design, Synthesis and Anticancer Evaluation of Some Novel 7-Hydroxy-4-Methyl-3-Substituted Benzopyran-2-One Derivatives	6
Design, synthesis, and molecular docking studies of thiazole derivatives against phospholipase A 2 ( Naja oxiana ) venom	5
Regulation of post-translational modification of PD-L1 and associated opportunities for novel small-molecule therapeutics	5
A novel class of potent antiangiogenic and antioxidant pyrazoles: synthesis, bioactivity, docking and ADMET studies	5
Innovative virtual screening of PD-L1 inhibitors: the synergy of molecular similarity, neural networks and GNINA docking	5
Combining Virtual Screening and In Vitro Evaluation for the Discovery of Potential CYP11B2 Inhibitors	5
Design and Synthesis of Novel Aza-Ursolic Acid Derivatives: In Vitro Cytotoxicity and Nitric Oxide Release Inhibitory Activity	5
Human Sirtuin 2 inhibitors, Their Mechanisms and Binding Modes	5
Enoxacin-Based Derivatives: Antimicrobial and Antibiofilm Agent: A Biology-Oriented Drug Synthesis (BIODS) Approach	5
Recent development of azole–sulfonamide hybrids with the anticancer potential	5
Recent advances in targeted degradation in the RAS pathway	5
Synthesis, cytotoxicity and 99m Tc-MIBI tumor cell uptake evaluation of 2-phenylbenzothiazole tagged triazole derivatives	5
Semicarbazone, thiosemicarbazone tailed isoxazoline-pyrazole: synthesis, DFT, biological and computational assessment	5
Urea-sugar and thiourea-sugar diastereomers: synthesis, crystal structure and biological activities	5

Targeting STK33: From Inhibition to Degradation	5
Glyco Disulfide Capped Gold Nanoparticle Synthesis: Cytotoxicity Studies and Effects on Lung Cancer A549 Cells	5
Our New Year's (re)solution: Welcome to the 15th Volume of Future Medicinal Chemistry	5
Therapeutic targeting of neuroinflammation in methamphetamine use disorder	5
Design, semi-synthesis and bioevaluation of koumine-like derivatives as potential antitumor agents in vitro and in vivo	5
Environment benign synthesis of 5-acyl-4-hydroxypyridin-2(1 H )-one derivatives as antioxidant and α -amylase inhibitors	5
Exploring the therapeutic potential and chemical properties of trans-chalcone: a comprehensive review	5
Development of indole hybrids for potential lung cancer treatment - part II	5
Unveiling the potential of HS-1793: a review of its anticancer properties and therapeutic promise	5
Gold: Not Just jewelry…	5
Prioritizing oral bioavailability in drug development strategies	5
Challenging Breast Cancer Through Novel sulfonamide–pyridine Hybrids: design, synthesis, Carbonic Anhydrase IX Inhibition and Induction of Apoptosis	5
Design, Synthesis and Structure–Activity Relationship Studies of Novel Spirochromanone Hydrochloride Analogs As Anticancer Agents	5
Parasitic Sirtuin 2 As an Opportunity in Drug Discovery	5