OOIR: Observatory of International Research

Papers

(The median citation count of Epigenetics & Chromatin is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Changes in DNA methylation hallmark alterations in chromatin accessibility and gene expression for eye lens differentiation	77
The role of genetic diversity, epigenetic regulation, and sex-based differences in HIV cure research: a comprehensive review	53
An optimized approach for multiplexing single-nuclear ATAC-seq using oligonucleotide-conjugated antibodies	52
Epigenetic regulation of MED12: a key contributor to the leukemic chromatin landscape and transcriptional dysregulation	50
Co-effects of m6A and chromatin accessibility dynamics in the regulation of cardiomyocyte differentiation	40
Proteins driving liquid-liquid phase separation and histone modifications cooperatively associate with chromatin looping and transcriptional regulation	39
Multilevel interrogation of H3.3 reveals a primordial role in transcription regulation	37
From compartments to loops: understanding the unique chromatin organization in neuronal cells	33
Detecting Protein-DNA binding in single molecules using antibody guided methylation	32
Chromatin structure and 3D architecture define the differential functions of PU.1 regulatory elements in blood cell lineages	30
Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development	29
Evolutionary adaptation of the Polycomb repressive complex 2	28
Partial erosion on under-methylated regions and chromatin reprogramming contribute to oncogene activation in IDH mutant gliomas	27
Who’s afraid of the X? Incorporating the X and Y chromosomes into the analysis of DNA methylation array data	24
Protamine expression in somatic cells condenses chromatin and disrupts transcription without altering DNA methylation	23
Acetylation modification of AIM2 by KAT2B suppresses the AKT/Wnt/β-catenin signaling pathway activation and inhibits breast cancer progression	23
Intrafamily heterooligomerization as an emerging mechanism of methyltransferase regulation	21
One-pot universal NicE-seq: all enzymatic downstream processing of 4% formaldehyde crosslinked cells for chromatin accessibility genomics	21
Chromatin balances cell redox and energy homeostasis	21
Development of super-specific epigenome editing by targeted allele-specific DNA methylation	20
Phthalates impact on the epigenetic factors contributed specifically by the father at fertilization	18
Roles of post-translational modifications of UHRF1 in cancer	18
Acquired sperm hypomethylation by gestational arsenic exposure is re-established in both the paternal and maternal genomes of post-epigenetic reprogramming embryos	18
Analysis of long-range chromatin contacts, compartments and looping between mouse embryonic stem cells, lens epithelium and lens fibers	18
CpG DNA methylation changes during epididymal sperm maturation in bulls	18

Heterosis of growth trait regulated by DNA methylation and miRNA in allotriploid fish	18
Native and tagged CENP-A histones are functionally inequivalent	17
Manipulating chromatin architecture in C. elegans	17
TP63–TRIM29 axis regulates enhancer methylation and chromosomal instability in prostate cancer	17
Integrated study of DNA methylation and transcriptome: a new perspective for exploring the pathogenesis of Sjögren's syndrome	16
Impact of chromatin on HIV-1 latency: a multi-dimensional perspective	15
H3K27me3 and the PRC1-H2AK119ub pathway cooperatively maintain heterochromatin and transcriptional silencing after the loss of H3K9 methylation	15
Multi-omic integration of single-cell data uncovers methylation profiles of super-enhancers in skeletal muscle stem cells	15
ING5: multifaceted roles beyond tumor suppression in cellular physiology and disease	15
PDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome	14
Maternal SMCHD1 controls both imprinted Xist expression and imprinted X chromosome inactivation	14
Mitochondrial supplementation of Sus scrofa metaphase II oocytes alters DNA methylation and gene expression profiles of blastocysts	14
Mechanism of non-coding RNA regulation of DNMT3A	14
Structural and functional specificity of H3K36 methylation	14
The WAC-downWAC domain in the yeast ISW2 nucleosome remodeling complex forms a structural module essential for ISW2 function but not cell viability	14
Epigenetic control of dental stem cells: progress and prospects in multidirectional differentiation	14
Knockout tales: the versatile roles of histone H3.3 in development and disease	14
Cohesin regulation of genome organization in mature granule neurons in the mouse cerebellum	13
Identification of genetic and non-genetic modifiers of genomic imprinting through screening of imprinted DMR methylation in humans	13
Reinforcement of repressive marks in the chicken primordial germ cell epigenetic signature: divergence from basal state resetting in mammals	13
Investigation of reversible histone acetylation and dynamics in gene expression regulation using 3D liver spheroid model	12
Making sense of the linear genome, gene function and TADs	12
Multi-omics analyses of MEN1 missense mutations identify disruption of menin–MLL and menin–JunD interactions as critical requirements for molecular pathogenicity	12
Effects of paternal exposure to cigarette smoke on sperm DNA methylation and long-term metabolic syndrome in offspring	12
TET-mediated DNA hydroxymethylation is negatively influenced by the PARP-dependent PARylation	11
Premature ovarian insufficiency is associated with global alterations in the regulatory landscape and gene expression in balanced X-autosome translocations	11
Prenatal nicotine exposure leads to epigenetic alterations in peripheral nervous system signaling genes in the testis of the rat	11
Genome-wide DNA methylation patterns in Daphnia magna are not significantly associated with age	10
Pioneer transcription factors are associated with the modulation of DNA methylation patterns across cancers	10
Var∣Decrypt: a novel and user-friendly tool to explore and prioritize variants in whole-exome sequencing data	10
Histone H3.3 K27M chromatin functions implicate a network of neurodevelopmental factors including ASCL1 and NEUROD1 in DIPG	10
Drosophila architectural proteins M1BP and Opbp cooperatively form the active promoter of a ribosomal protein gene	10
Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches	10
Hypoxic in vitro culture reduces histone lactylation and impairs pre-implantation embryonic development in mice	10
Risk-focused differences in molecular processes implicated in SARS-CoV-2 infection: corollaries in DNA methylation and gene expression	10
TET1 functions as a tumor suppressor in lung adenocarcinoma through epigenetic remodeling and immune modulation	10
The linker histone chaperone Prothymosin α (PTMA) is essential for efficient DNA damage repair and the recruitment of PARP1	9
Promoter hypermethylation of neural-related genes is compatible with stemness in solid cancers	9
Revealing RCOR2 as a regulatory component of nuclear speckles	9
PCGF6/MAX/KDM5D facilitates MAZ/CDK4 axis expression and pRCC progression by hypomethylation of the DNA promoter	9
Cohesin stabilization at promoters and enhancers by common transcription factors and chromatin regulators	9
Functions of HP1 proteins in transcriptional regulation	9
H3K4me3 regulates the transcription of RSPO3 in dermal papilla cells to influence hair follicle morphogenesis and development	9
Dissecting the Kaiso binding profile in clear renal cancer cells	8
Functional characterization of transcriptional enhancers in an Anopheles genetic locus controlling natural resistance to the malaria parasite, Plasmodium falciparum	8
The transgenic IG-DMR sequence of the mouse Dlk1-Dio3 domain acquired imprinted DNA methylation during the post-fertilization period	8
Folate deficiency reduced aberrant level of DOT1L-mediated histone H3K79 methylation causes disruptive SHH gene expression involved in neural tube defects	8
Multigenerational temperature effects on paternal epigenetic inheritance in European sea bass	8
Analyses of POL30 (PCNA) reveal positional effects in transient repression or bi-modal active/silent state at the sub-telomeres of S. cerevisiae	8
Correction: Characterizing chromatin interactions of regulatory elements and nucleosome positions, using Hi‑C, Micro‑C, and promoter capture Micro‑C	8

Histone modification analysis reveals common regulators of gene expression in liver and blood stage merozoites of Plasmodium parasites	8
The isoflavone genistein selectively stimulates major satellite repeat transcription in mouse heterochromatin	7
Imprinted DNA methylation of the H19 ICR is established and maintained in vivo in the absence of Kaiso	7
Expanding the list of sequence-agnostic enzymes for chromatin conformation capture assays with S1 nuclease	7
DNA methylation may affect beef tenderness through signal transduction in Bos indicus	7
Improved epigenetic age prediction models by combining sex chromosome and autosomal markers	7
Deconvolution of the epigenetic age discloses distinct inter-personal variability in epigenetic aging patterns	7
Long-term exposure to diesel exhaust particles induces concordant changes in DNA methylation and transcriptome in human adenocarcinoma alveolar basal epithelial cells	6
Chromatin alterations during the epididymal maturation of mouse sperm refine the paternally inherited epigenome	6
The mismatch-repair proteins MSH2 and MSH6 interact with the imprinting control regions through the ZFP57-KAP1 complex	6
A standardized nomenclature for mammalian histone genes	6
H3K9 post-translational modifications regulate epiblast/primitive endoderm specification in rabbit blastocysts	5
Chromatin accessibility and cell cycle progression are controlled by the HDAC-associated Sin3B protein in murine hematopoietic stem cells	5
Bromodomain proteins IBD1 and IBD2 link histone acetylation to SWR1- and INO80-mediated H2A.Z regulation in Tetrahymena	5
DNA methylation correlates of chronological age in diverse human tissue types	5
The MMP-2 histone H3 N-terminal tail protease is selectively targeted to the transcription start sites of active genes	5
Characterizing chromatin interactions of regulatory elements and nucleosome positions, using Hi-C, Micro-C, and promoter capture Micro-C	5
Methylation patterns at the adjacent CpG sites within enhancers are a part of cell identity	5
Transcriptional regulation mechanism of PARP1 and its application in disease treatment	5
Multiple distinct domains of human XIST are required to coordinate gene silencing and subsequent heterochromatin formation	5
Integrative analysis of gene expression and chromatin dynamics multi-omics data in mouse models of bleomycin-induced lung fibrosis	5
The regional sequestration of heterochromatin structural proteins is critical to form and maintain silent chromatin	5
Nucleophosmin 1 cooperates with the methyltransferase DOT1L to preserve peri-nucleolar heterochromatin organization by regulating H3K27me3 levels and DNA repeats expression	4
Pan-cancer predictions of transcription factors mediating aberrant DNA methylation	4
3DFAACTS-SNP: using regulatory T cell-specific epigenomics data to uncover candidate mechanisms of type 1 diabetes (T1D) risk	4
LSD1 induces H3 K9 demethylation to promote adipogenesis in thyroid-associated ophthalmopathy	4
Disruption of histone acetylation homeostasis reveals multilayered chromatin regulation for transcriptional resiliency	4
FOSL1 is a key regulator of a super-enhancer driving TCOF1 expression in triple-negative breast cancer	4
Correction: Dissecting the Kaiso binding profle in clear renal cancer cells	4
Multiple epigenetic factors co-localize with HMGN proteins in A-compartment chromatin	4
Efficient generation of epigenetic disease model mice by epigenome editing using the piggyBac transposon system	4