OOIR: Observatory of International Research

Papers

(The median citation count of Epigenetics & Chromatin is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Effects of topological domain disruption on transcriptional regulation are chromatin context dependent	66
DNA methylation reshapes the expression of adipokines and adipose factors in white adipose tissues	64
The role of genetic diversity, epigenetic regulation, and sex-based differences in HIV cure research: a comprehensive review	60
Time-course ATAC-seq and RNA-seq analysis of porcine synovium-derived mesenchymal stem cells under in vitro osteogenic induction	45
An optimized approach for multiplexing single-nuclear ATAC-seq using oligonucleotide-conjugated antibodies	44
Epigenetic regulation of MED12: a key contributor to the leukemic chromatin landscape and transcriptional dysregulation	42
Multilevel interrogation of H3.3 reveals a primordial role in transcription regulation	39
Proteins driving liquid-liquid phase separation and histone modifications cooperatively associate with chromatin looping and transcriptional regulation	38
Cooperation between architectural C2H2 proteins in CP190 recruitment to Drosophila regulatory elements	32
From compartments to loops: understanding the unique chromatin organization in neuronal cells	31
Features of DNA methylome in Capsicum spp.	28
Local chromatin context informs transcriptional outcomes for the histone demethylase KDM5	27
Detecting Protein-DNA binding in single molecules using antibody guided methylation	27
Co-effects of m6A and chromatin accessibility dynamics in the regulation of cardiomyocyte differentiation	27
Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development	25
Acetylation modification of AIM2 by KAT2B suppresses the AKT/Wnt/β-catenin signaling pathway activation and inhibits breast cancer progression	23
Partial erosion on under-methylated regions and chromatin reprogramming contribute to oncogene activation in IDH mutant gliomas	23
Gain of function p53 mutant R273H confers distinct methylation profiles and consequent YAP/TAZ signaling mediated activation of partial or full EMT states to colon tumours	23
Chromatin structure and 3D architecture define the differential functions of PU.1 regulatory elements in blood cell lineages	23
Protamine expression in somatic cells condenses chromatin and disrupts transcription without altering DNA methylation	23
Mechanistic basis for the opposing effects of H2A and H2B ubiquitination on nucleosome stability and dynamics	23
Who’s afraid of the X? Incorporating the X and Y chromosomes into the analysis of DNA methylation array data	22
Intrafamily heterooligomerization as an emerging mechanism of methyltransferase regulation	21
Chromatin balances cell redox and energy homeostasis	21
Analysis of long-range chromatin contacts, compartments and looping between mouse embryonic stem cells, lens epithelium and lens fibers	20

Heterosis of growth trait regulated by DNA methylation and miRNA in allotriploid fish	20
Development of super-specific epigenome editing by targeted allele-specific DNA methylation	20
CpG DNA methylation changes during epididymal sperm maturation in bulls	20
Roles of post-translational modifications of UHRF1 in cancer	19
Phthalates impact on the epigenetic factors contributed specifically by the father at fertilization	18
Manipulating chromatin architecture in C. elegans	17
ING5: multifaceted roles beyond tumor suppression in cellular physiology and disease	17
Acquired sperm hypomethylation by gestational arsenic exposure is re-established in both the paternal and maternal genomes of post-epigenetic reprogramming embryos	17
TP63–TRIM29 axis regulates enhancer methylation and chromosomal instability in prostate cancer	17
Multi-omic integration of single-cell data uncovers methylation profiles of super-enhancers in skeletal muscle stem cells	17
WDR-5 exhibits H3K4 methylation-independent activity during embryonic development in C. elegans	17
Loss of maternal PADI6 disrupts DNA methylation and genomic imprinting maintenance in late preimplantation mouse embryos	17
Integrated study of DNA methylation and transcriptome: a new perspective for exploring the pathogenesis of Sjögren's syndrome	16
Impact of chromatin on HIV-1 latency: a multi-dimensional perspective	16
Native and tagged CENP-A histones are functionally inequivalent	16
H3K27me3 and the PRC1-H2AK119ub pathway cooperatively maintain heterochromatin and transcriptional silencing after the loss of H3K9 methylation	15
Maternal SMCHD1 controls both imprinted Xist expression and imprinted X chromosome inactivation	14
PDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome	14
The WAC-downWAC domain in the yeast ISW2 nucleosome remodeling complex forms a structural module essential for ISW2 function but not cell viability	14
Mechanism of non-coding RNA regulation of DNMT3A	13
Reinforcement of repressive marks in the chicken primordial germ cell epigenetic signature: divergence from basal state resetting in mammals	13
Structural and functional specificity of H3K36 methylation	13
Knockout tales: the versatile roles of histone H3.3 in development and disease	13
Epigenetic control of dental stem cells: progress and prospects in multidirectional differentiation	13
Histone H3.3 K27M chromatin functions implicate a network of neurodevelopmental factors including ASCL1 and NEUROD1 in DIPG	12
Identification of genetic and non-genetic modifiers of genomic imprinting through screening of imprinted DMR methylation in humans	12
Investigation of reversible histone acetylation and dynamics in gene expression regulation using 3D liver spheroid model	12
Cohesin regulation of genome organization in mature granule neurons in the mouse cerebellum	12
Prenatal nicotine exposure leads to epigenetic alterations in peripheral nervous system signaling genes in the testis of the rat	12
Multi-omics analyses of MEN1 missense mutations identify disruption of menin–MLL and menin–JunD interactions as critical requirements for molecular pathogenicity	12
From chromosomal protein disorder to chromatin phase separation	12
Premature ovarian insufficiency is associated with global alterations in the regulatory landscape and gene expression in balanced X-autosome translocations	11
Drosophila architectural proteins M1BP and Opbp cooperatively form the active promoter of a ribosomal protein gene	11
Optimizing genetic ancestry adjustment in DNA methylation studies: a comparative analysis of approaches	11
Genome-wide DNA methylation patterns in Daphnia magna are not significantly associated with age	11
ZAD mediates chromatin binding and insulator activity of Drosophila Pita and can be replaced with the human ZFP276 ZAD-like domain	11
TET1 functions as a tumor suppressor in lung adenocarcinoma through epigenetic remodeling and immune modulation	10
Var∣Decrypt: a novel and user-friendly tool to explore and prioritize variants in whole-exome sequencing data	10
Promoter hypermethylation of neural-related genes is compatible with stemness in solid cancers	10
The linker histone chaperone Prothymosin α (PTMA) is essential for efficient DNA damage repair and the recruitment of PARP1	9
H3K4me3 regulates the transcription of RSPO3 in dermal papilla cells to influence hair follicle morphogenesis and development	9
Cohesin stabilization at promoters and enhancers by common transcription factors and chromatin regulators	9
PCGF6/MAX/KDM5D facilitates MAZ/CDK4 axis expression and pRCC progression by hypomethylation of the DNA promoter	9
Functions of HP1 proteins in transcriptional regulation	9
Integrating single-cell transcriptomics and epigenetics in a multi-omics MR framework identifies PARK7 as a causal gene in streptococcal septicemia	9
Dissecting the Kaiso binding profile in clear renal cancer cells	8
The transgenic IG-DMR sequence of the mouse Dlk1-Dio3 domain acquired imprinted DNA methylation during the post-fertilization period	8
Dna methylation dynamics associated with visual system remodeling during flatfish metamorphosis	8
Folate deficiency reduced aberrant level of DOT1L-mediated histone H3K79 methylation causes disruptive SHH gene expression involved in neural tube defects	7
Analyses of POL30 (PCNA) reveal positional effects in transient repression or bi-modal active/silent state at the sub-telomeres of S. cerevisiae	7

Expanding the list of sequence-agnostic enzymes for chromatin conformation capture assays with S1 nuclease	7
Histone modification analysis reveals common regulators of gene expression in liver and blood stage merozoites of Plasmodium parasites	7
Multigenerational temperature effects on paternal epigenetic inheritance in European sea bass	7
DNA methylation may affect beef tenderness through signal transduction in Bos indicus	7
Correction: Acetylation modification of AIM2 by KAT2B suppresses the AKT/Wnt/β-catenin signaling pathway activation and inhibits breast cancer progression	7
Functional characterization of transcriptional enhancers in an Anopheles genetic locus controlling natural resistance to the malaria parasite, Plasmodium falciparum	7
Correction: Characterizing chromatin interactions of regulatory elements and nucleosome positions, using Hi‑C, Micro‑C, and promoter capture Micro‑C	7
Imprinted DNA methylation of the H19 ICR is established and maintained in vivo in the absence of Kaiso	7
An RNAi-based platform for spatiotemporal control of histone gene expression during animal development	6
Characterizing chromatin interactions of regulatory elements and nucleosome positions, using Hi-C, Micro-C, and promoter capture Micro-C	6
The isoflavone genistein selectively stimulates major satellite repeat transcription in mouse heterochromatin	6
Chromatin accessibility and cell cycle progression are controlled by the HDAC-associated Sin3B protein in murine hematopoietic stem cells	6
Bromodomain proteins IBD1 and IBD2 link histone acetylation to SWR1- and INO80-mediated H2A.Z regulation in Tetrahymena	6
A standardized nomenclature for mammalian histone genes	6
Methylation patterns at the adjacent CpG sites within enhancers are a part of cell identity	6
Improved epigenetic age prediction models by combining sex chromosome and autosomal markers	6
The mismatch-repair proteins MSH2 and MSH6 interact with the imprinting control regions through the ZFP57-KAP1 complex	6
High-resolution map of chromatin accessibility - insights into the focused binding of a large number of transcription factors	6
Long-term exposure to diesel exhaust particles induces concordant changes in DNA methylation and transcriptome in human adenocarcinoma alveolar basal epithelial cells	5
H3K9 post-translational modifications regulate epiblast/primitive endoderm specification in rabbit blastocysts	5
5-Hydroxymethylcytosine: a key epigenetic mark in cancer and chemotherapy response	5
Multiple epigenetic factors co-localize with HMGN proteins in A-compartment chromatin	5
Integrative analysis of gene expression and chromatin dynamics multi-omics data in mouse models of bleomycin-induced lung fibrosis	5
DNA methylation correlates of chronological age in diverse human tissue types	5
Comparative validation of oxidative bisulfite sequencing (oxBS) and chemical-assisted pyridine borane sequencing (CAPS) protocols for locus-specific 5-hydroxymethylcytosine quantification	5
LSD1 induces H3 K9 demethylation to promote adipogenesis in thyroid-associated ophthalmopathy	5
3DFAACTS-SNP: using regulatory T cell-specific epigenomics data to uncover candidate mechanisms of type 1 diabetes (T1D) risk	5
The impact of fulvestrant on estrogen receptor-driven chromatin dynamics in breast cancer cells	5
The MMP-2 histone H3 N-terminal tail protease is selectively targeted to the transcription start sites of active genes	5
Transcriptional regulation mechanism of PARP1 and its application in disease treatment	5
Disruption of histone acetylation homeostasis reveals multilayered chromatin regulation for transcriptional resiliency	5
Genome-wide demethylation and targeted remethylation during metamorphosis in the jewel wasp Nasonia vitripennis	5
FOSL1 is a key regulator of a super-enhancer driving TCOF1 expression in triple-negative breast cancer	4
DNA variants affecting chromatin structure are key to the genetic architecture of obsessive compulsive disorder	4
Efficient generation of epigenetic disease model mice by epigenome editing using the piggyBac transposon system	4
Correction to: Open chromatin analysis in Trypanosoma cruzi life forms highlights critical differences in genomic compartments and developmental regulation at tDNA loci	4
Nucleophosmin 1 cooperates with the methyltransferase DOT1L to preserve peri-nucleolar heterochromatin organization by regulating H3K27me3 levels and DNA repeats expression	4
Contributions of DNA mechanics and trans-regulation to nucleosome positioning in Schizosaccharomyces pombe and its role in co-transcriptional splicing	4
Placental imprinting of SLC22A3 in the IGF2R imprinted domain is conserved in therian mammals	4
Developmentally dynamic chromatin state at loci regulating organ crosstalk by remote sensing and signaling	4
Correction: Dissecting the Kaiso binding profle in clear renal cancer cells	4
Unraveling the cohesin-chromatin interface: identifying protein interactions that modulate chromosome structure and function	4
Assessment of relationships between epigenetic age acceleration and multiple sclerosis: a bidirectional mendelian randomization study	4
H3F3A K27M mutations drive a repressive transcriptome by modulating chromatin accessibility independent of H3K27me3 in Diffuse Midline Glioma	4