OOIR: Observatory of International Research

Papers

(The H4-Index of Genome Medicine is 51. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Correction: Intricate interplay of CRISPR-Cas systems, anti-CRISPR proteins, and antimicrobial resistance genes in a globally successful multi-drug resistant Klebsiella pneumoniae clone	757
Loss of p53-DREAM-mediated repression of cell cycle genes as a driver of lymph node metastasis in head and neck cancer	297
Genome-aware annotation of CRISPR guides validates targets in variant cell lines and enhances discovery in screens	268
Genome-wide methylation detection and episignature analysis using PacBio long-read sequencing	259
Beyond the exome: utility of long-read whole genome sequencing in exome-negative autosomal recessive diseases	251
The role of admixture in the rare variant contribution to inflammatory bowel disease	238
Leveraging new methods for comprehensive characterization of mitochondrial DNA in esophageal squamous cell carcinoma	174
African ancestry-enriched variants in the GATM gene are associated with elevated serum creatinine levels	159
Curating genomic disease-gene relationships with Gene2Phenotype (G2P)	133
Pervasiveness of HLA allele-specific expression loss across tumor types	125
Neutrophil extracellular traps have auto-catabolic activity and produce mononucleosome-associated circulating DNA	105
Single-cell transcriptome analysis defines novel molecular subtypes and reveals therapeutic implications of T/myeloid mixed-phenotype acute leukemia	105
Single-molecule methylation profiles of cell-free DNA in cancer with nanopore sequencing	101
The multiple de novo copy number variant (MdnCNV) phenomenon presents with peri-zygotic DNA mutational signatures and multilocus pathogenic variation	97
Clinical characteristics and molecular heterogeneity in Follicular lymphoma with extranodal involvement	95
Contribution of rare coding variants to microcephaly in individuals with neurodevelopmental disorders	92
Spatial intra-tumour heterogeneity and treatment-induced genomic evolution in oesophageal adenocarcinoma: implications for prognosis and therapy	92
Ethnic variations in metabolic syndrome components and their associations with the gut microbiota: the HELIUS study	84
Whole-genome sequencing reveals individual and cohort level insights into chromosome 9p syndromes	84
Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts	81
INSaFLU-TELEVIR: an open web-based bioinformatics suite for viral metagenomic detection and routine genomic surveillance	79
Investigating the interplay between prematurity and genetic variation in the context of rare developmental disorders	75
Replication-associated mechanisms contribute to an increased CpG > TpG mutation burden in mismatch repair-deficient cancers	75
GWAS-by-subtraction reveals new genetic architecture and health implications of type 2 diabetes-independent gestational diabetes mellitus	75
Universal clinical Parkinson’s disease axes identify a major influence of neuroinflammation	74

The impact of the COVID-19 pandemic and associated lifestyle changes on early-life microbiome development	72
De novo identification of expressed cancer somatic mutations from single-cell RNA sequencing data	71
Adult genomic medicine: lessons from a multisite study of 2700 patients	69
Publisher Correction: Analysis of transcriptomic features reveals molecular endotypes of SLE with clinical implications	67
The landcape of Helicobacter pylori-mediated DNA breaks links bacterial genotoxicity to its oncogenic potential	67
The lung microbiome, peripheral gene expression, and recurrence-free survival after resection of stage II non-small cell lung cancer	64
Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis	64
Diversity in EWAS: current state, challenges, and solutions	63
DNA demethylation triggers cell free DNA release in colorectal cancer cells	63
Genomic and transcriptomic features between primary and paired metastatic fumarate hydratase–deficient renal cell carcinoma	62
MicroRNA gene dynamics in immune cell subpopulations during aging and atherosclerosis disease development at single-cell resolution	61
Transcriptome-wide association study revealed novel causal genes of renal-biopsy proven diabetic nephropathy	61
Correction: Genome Med 15, 115 & Genome Med 16, 3	61
Metabolome-wide Mendelian randomization for age at menarche and age at natural menopause	59
Cancer evolution and multi-omic profile of relapsed colorectal liver metastases after treatment	58
Biological basis of extensive pleiotropy between blood traits and cancer risk	58
Identifying intra-hospital Norovirus GII transmission using whole-genome sequencing	57
Comprehensive pathogen identification and antimicrobial resistance prediction from positive blood cultures using nanopore sequencing technology	56
Neutralization sensitivity, fusogenicity, and infectivity of Omicron subvariants	55
Tracing carriage, acquisition, and transmission of ESBL-producing Escherichia coli over two years in a tertiary care hospital	54
ClinVar and HGMD genomic variant classification accuracy has improved over time, as measured by implied disease burden	54
Longitudinal analysis of genetic and environmental interplay in human metabolic profiles and the implication for metabolic health	53
A human YEATS4 variant confers resistance to TST and IGRA conversion despite Mycobacterium tuberculosis exposure	53
Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profiles	53
Skeletal muscle regeneration failure in ischemic-damaged limbs is associated with pro-inflammatory macrophages and premature differentiation of satellite cells	52
Single-cell transcriptomics reveals a mechanosensitive injury signaling pathway in early diabetic nephropathy	52
Full-spectral genome analysis of natural killer/T cell lymphoma highlights impacts of genome instability in driving its progression	51