EMBO Molecular Medicine

Article	Citations
miR‐9 modulates and predicts the response to radiotherapy and EGFR inhibition in HNSCC	335
Autologous, lentivirus‐modified, T‐rapa cell “micropharmacies” for lysosomal storage disorders	223
Circulating proteomic panels for risk stratification of intracranial aneurysm and its rupture	134
Whole‐brain microscopy reveals distinct temporal and spatial efficacy of anti‐Aβ therapies	132
THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer	124
The state of the art of bispecific antibodies for treating human malignancies	118
A preclinical model of peripheral T‐cell lymphoma GATA3 reveals DNA damage response pathway vulnerability	112
Targeting the Leukemic stem cell protein machinery by inhibition of mitochondrial pyrimidine synthesis	106
Targetable Brg1‐CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking	91
Targeting conformational changes in C‐reactive protein to inhibit pro‐inflammatory actions	88
Elongator and the role of its subcomplexes in human diseases	82
HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy	70
Depressive patient‐derived GABA interneurons reveal abnormal neural activity associated with HTR2C	68
TFEB and TFE3 drive kidney cystogenesis and tumorigenesis	65
Flower lose, a cell fitness marker, predicts COVID‐19 prognosis	64
IQCN disruption causes fertilization failure and male infertility due to manchette assembly defect	63
When fat meets the gut—focus on intestinal lipid handling in metabolic health and disease	63
Activation of the integrated stress response is a vulnerability for multidrug‐resistant FBXW7 ‐deficient cells	62
Glomerular endothelial cell senescence drives age‐related kidney disease through PAI‐1	56
ASO targeting RBM3 temperature‐controlled poison exon splicing prevents neurodegeneration in vivo	55
Metformin rescues migratory deficits of cells derived from patients with periventricular heterotopia	55
Identification of treatment‐induced vulnerabilities in pancreatic cancer patients using functional model systems	54
Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain	54
Eosinophil‐derived IL ‐4 is necessary to establish the inflammatory structure in innate inflammation	53
Diagnostic biomarkers for active tuberculosis: progress and challenges	53

Systemic inflammation after stroke: implications for post‐stroke comorbidities	50
Tau PET correlates with different Alzheimer’s disease‐related features compared to CSF and plasma p‐tau biomarkers	49
Single‐cell profiling of muscle‐infiltrating T cells in idiopathic inflammatory myopathies	49
Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy	49
Nerve regeneration by interferon intervention in aging brain	48
Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer	48
Pharmacological or genetic inhibition of iNOS prevents cachexia‐mediated muscle wasting and its associated metabolism defects	48
Shear stress control of vascular leaks and atheromas through Tie2 activation by VE‐PTP sequestration	47
Spleen tyrosine kinase mediates innate and adaptive immune crosstalk in SARS‐CoV‐2 mRNA vaccination	46
Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model	44
Functions of double‐negative B cells in autoimmune diseases, infections, and cancers	44
Advances in high‐throughput mass spectrometry in drug discovery	43
ALX1 ‐related frontonasal dysplasia results from defective neural crest cell development and migration	43
Looking at a baby's heart through the lens of the mother's blood	43
Mining the bacterial genome to discover new antimicrobial molecules	42
In vitro and in vivo drug screens of tumor cells identify novel therapies for high‐risk child cancer	41
Optimizing the Cas13 antiviral train: cargo and delivery	40
Macrophage colony‐stimulating factor as a weapon against cytomegalovirus	40
A type IV Autotaxin inhibitor ameliorates acute liver injury and nonalcoholic steatohepatitis	39
In vivo single‐cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection	39
Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease	38
Blocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T‐cell lymphoma	38
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy	37
TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT	37
The human host response to monkeypox infection: a proteomic case series study	36
An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV ‐2	36
The molecular biology of peritoneal metastatic disease	36
Sex differences and risk factors for bleeding in Alagille syndrome	35
Immuno(T)herapy for age‐related diseases	35
Deconstructing progressive inflammatory fibrosis in recessive dystrophic epidermolysis bullosa	34
AAV induces hepatic necroptosis and carcinoma in diabetic and obese mice dependent on Pebp1 pathway	34
A novel platform for attenuating immune hyperactivity using EXO‐CD24 in COVID‐19 and beyond	34
Elucidating effects of environmental exposure using human‐induced pluripotent stem cell disease modeling	34
Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis	33
LAG3 is not expressed in human and murine neurons and does not modulate α‐synucleinopathies	33
miR ‐181a/b downregulation: a mutation‐independent therapeutic approach for inherited retinal diseases	33
Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation	33
Trichothiodystrophy‐associated MPLKIP maintains DBR1 levels for proper lariat debranching and ectodermal differentiation	33
X‐linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL	33
IL‐27 produced during acute malaria infection regulates Plasmodium‐specific memory CD4+ T cells	32
Rational design of West Nile virus vaccine through large replacement of 3′ UTR with internal poly(A)	32
Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis	32
Nanobody‐mediated complement activation to kill HIV‐infected cells	32
Systemic gene therapy rescues retinal dysfunction and hearing loss in a model of Norrie disease	32
Alleviation of a polyglucosan storage disorder by enhancement of autophagic glycogen catabolism	31
External validity in translational biomedicine: understanding the conditions enabling the cause to have an effect	31
YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis	30
A progeroid syndrome caused by a deep intronic variant in TAPT1 is revealed by RNA/SI‐NET sequencing	30
Liver gene therapy with intein‐mediated F8 trans ‐splicing corrects mouse haemophilia A	30
AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model	30

Adaptively evolved human oral actinomyces‐sourced defensins show therapeutic potential	30
Molecular and functional properties of human Plasmodium falciparum CSP C‐terminus antibodies	29
TAPT1—at the crossroads of extracellular matrix and signaling in Osteogenesis imperfecta	29
Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in SARS‐CoV‐2 mouse models of infection	29
Nuclear PRMT5 is a biomarker of sensitivity to tamoxifen in ERα+ breast cancer	29
Development of allogeneic iPS cell‐based therapy: from bench to bedside	28
Answer to Gerber et al. “Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy”	28
NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5	28
Dual IRE1 RNase functions dictate glioblastoma development	28
Full eradication of pre‐clinical human papilloma virus‐induced tumors by a lentiviral vaccine	28
A spoonful of L‐fucose—an efficient therapy for GFUS‐CDG, a new glycosylation disorder	28
A clinically compatible drug‐screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis	27
Transfixed by transgenics: how pathology assumptions are slowing progress in Alzheimer's disease and related dementia research	27
RNAi to treat SARS‐CoV‐2—variant proofing the next generation of therapies	27
Patient‐ and xenograft‐derived organoids recapitulate pediatric brain tumor features and patient treatments	27
microRNAs trip down memory lane	27
Uncovering a conserved vulnerability site in SARS‐CoV‐2 by a human antibody	27
Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcoma	27
Gene therapy in the putamen for curing AADC deficiency and Parkinson's disease	27
SPINK6 inhibits human airway serine proteases and restricts influenza virus activation	26
Lack of the human choline transporter‐like protein SLC44A2 causes hearing impairment and a rare red blood phenotype	26
BET1 variants establish impaired vesicular transport as a cause for muscular dystrophy with epilepsy	26
MSTO1 is a cytoplasmic pro‐mitochondrial fusion protein, whose mutation induces myopathy and ataxia in humans	25
A whole‐genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors	25
AAV‐delivered diacylglycerol kinase DGKk achieves long‐term rescue of fragile X syndrome mouse model	25
Correction of oxidative stress enhances enzyme replacement therapy in Pompe disease	25
COVID‐19 vaccination, time for a second breath?	24
Long non‐coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling	24
The Sec61 translocon is a therapeutic vulnerability in multiple myeloma	24
Targeting the liver to treat the eye	24
Disrupting metformin adaptation of liver cancer cells by targeting the TOMM34/ATP5B axis	24
Blockade of the pro‐fibrotic reaction mediated by the miR‐143/‐145 cluster enhances the responses to targeted therapy in melanoma	23
Mitogen‐activated protein kinase activity drives cell trajectories in colorectal cancer	23
Clinical grade ACE2 as a universal agent to block SARS‐CoV ‐2 variants	23
Molecular mechanisms for the modulation of blood pressure and potassium homeostasis by the distal convoluted tubule	23
Epigenetic silencing of SALL2 confers tamoxifen resistance in breast cancer	23
Repurposing immunosuppressants for antileukemia therapy	22
Individual COVID‐19 disease trajectories revealed by plasma proteomics	22
mAb therapy controls CNS‐resident lyssavirus infection via a CD4 T cell‐dependent mechanism	22
Alteration of microbiota antibody‐mediated immune selection contributes to dysbiosis in inflammatory bowel diseases	22
Antagonizing microRNA ‐19a/b augments PTH anabolic action and restores bone mass in osteoporosis in mice	22
Functional genomics approaches to improve pre‐clinical drug screening and biomarker discovery	22
DGAT inhibition at the post‐absorptive phase reduces plasma FA by increasing FA oxidation	22
Propionate reinforces epithelial identity and reduces aggressiveness of lung carcinoma	22
Intestinal Apc‐inactivation induces HSP25 dependency	22
Long non‐coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling	21
Anti‐tumoural activity of the G‐quadruplex ligand pyridostatin against BRCA1/2‐deficient tumours	21
A nontyphoidal Salmonella serovar domestication accompanying enhanced niche adaptation	21
Seasonality of influenza and other respiratory viruses	21
Therapeutic activation of endothelial sphingosine‐1‐phosphate receptor 1 by chaperone‐bound S1P suppresses proliferative retinal neovascularization	21
β‐Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T‐cell acute lymphoblastic leukemia	21
Interactions between BRD4S, LOXL2, and MED1 drive cell cycle transcription in triple‐negative breast cancer	21
Gut microbiota‐CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten‐induced enteropathy	21
Adoptive T cell therapy cures mice from active hemophagocytic lymphohistiocytosis (HLH)	20
Inhibiting parasite proliferation using a rationally designed anti‐tubulin agent	20
Interferon regulates neural stem cell function at all ages by orchestrating mTOR and cell cycle	20
IMPDH inhibition activates TLR‐VCAM1 pathway and suppresses the development of MLL‐fusion leukemia	20
Liver‐directed gene therapy for ornithine aminotransferase deficiency	20
Immunological barriers to immunotherapy in primary and metastatic breast cancer	20
Oxidized LDL‐dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy	20
Early 5‐HT 6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse	20
Cingulin regulates hair cell cuticular plate morphology and is required for hearing in human and mouse	20
A catalog of numerical centrosome defects in epithelial ovarian cancers	20
Maternal diet and gut microbiome composition modulate early‐life immune development	20
Tumor‐associated macrophages‐educated reparative macrophages promote diabetic wound healing	19
iPSC‐based modeling of THD recapitulates disease phenotypes and reveals neuronal malformation	19
A high‐resolution 3D atlas of the spectrum of tuberculous and COVID ‐19 lung lesions	19
Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ‐secretase activity	19
Can THEM6 targeting stop resistance to prostate cancer treatment?	18
Myeloid cell‐based delivery of IFN‐γ reprograms the leukemia microenvironment and induces anti‐tumoral immune responses	18
Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons	18
Cysteamine–bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis	18
Enhancement of efferocytosis through biased FPR2 signaling attenuates intestinal inflammation	18
Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19	18
Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson–Gilford Progeria	18
Sensitivity towards HDAC inhibition is associated with RTK / MAPK pathway activation in gastric	18
Dependence receptors: new targets for cancer therapy	18
Immunotherapy targeting isoDGR‐protein damage extends lifespan in a mouse model of protein deamidation	17
Microbiota dysbiosis influences immune system and muscle pathophysiology of dystrophin‐deficient mice	17
Oxidative stress enhances the therapeutic action of a respiratory inhibitor in MYC‐driven lymphoma	17

Ang2 inhibitors and Tie2 activators: potential therapeutics in perioperative treatment of early stage cancer	17
Dual IRE1 RNase functions dictate glioblastoma development	17
Targeting CRAC channels in inflammatory bowel disease	17
The global emergence of a novel Streptococcus suis clade associated with human infections	17
Emerging roles of ATG7 in human health and disease	17
Single‐cell transcriptomics reveals a senescence‐associated IL ‐6/ CCR6 axis driving radiodermatitis	16
Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability	16
Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy	16
Intratumoral co‐injection of NK cells and NKG2A‐neutralizing monoclonal antibodies	16
Fuse your mitochondria, lose appetite: an anorexic, anti‐obesity sphingolipid	16
Artificial sweeteners inhibit multidrug‐resistant pathogen growth and potentiate antibiotic activity	16
Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia	15
Allelic effects on uromodulin aggregates drive autosomal dominant tubulointerstitial kidney disease	15
Neuropilin‐1 ( NRP1 ) expression distinguishes self‐reactive helper T cells in systemic autoimmune disease	15
Synergistic effects of FGFR1 and PLK1 inhibitors target a metabolic liability in KRAS ‐mutant cancer	15
Graft conditioning with fluticasone propionate reduces graft‐versus‐host disease upon allogeneic hematopoietic cell transplantation in mice	15
Mutated axon guidance gene PLXNB2 sustains growth and invasiveness of stem cells isolated from cancers of unknown primary	15
Caspase‐8 in endothelial cells maintains gut homeostasis and prevents small bowel inflammation in mice	15
Acquired immunity against SARS‐CoV‐2 infection and vaccination	15
Microbial metabolites in chronic heart failure and its common comorbidities	15
LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease	15
Propylene glycol inactivates respiratory viruses and prevents airborne transmission	15
When dysbiosis meets dystrophy: an unwanted gut‐muscle connection	15
Genetically modified macrophages accelerate myelin repair	15
Inhibition of O‐GlcNAcylation protects from Shiga toxin‐mediated cell injury and lethality in host	15
Modeling genetic epileptic encephalopathies using brain organoids	15
Lifting the iron curtain of vision	14
A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy	14
The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity	14
Nanog maintains stemness of Lkb1 ‐deficient lung adenocarcinoma and prevents gastric differentiation	14
Inhibition of NPC1L1 disrupts adaptive responses of drug‐tolerant persister cells to chemotherapy	14
Sigma‐1 receptor attenuates osteoclastogenesis by promoting ER‐associated degradation of SERCA2	14
S1P defects cause a new entity of cataract, alopecia, oral mucosal disorder, and psoriasis‐like syndrome	14
Feed‐forward loops between metastatic cancer cells and their microenvironment—the stage of escalation	14
Live imaging of neolymphangiogenesis identifies acute antimetastatic roles of dsRNA mimics	14
Aged lipid‐laden microglia display impaired responses to stroke	14
Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy	14
FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder	14