EMBO Molecular Medicine

Article	Citations
The role of interleukin‐6 in monitoring severe case of coronavirus disease 2019	232
YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis	221
Mechanism of baricitinib supports artificial intelligence‐predicted testing in COVID ‐19 patients	213
Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer’s continuum when only subtle changes in Aβ pathology ar	204
Delivery of oligonucleotide‐based therapeutics: challenges and opportunities	185
SARS ‐CoV‐2, bacterial co‐infections, and AMR : the deadly trio in COVID ‐19?	160
Sarcoma treatment in the era of molecular medicine	150
Altered bioenergetics and mitochondrial dysfunction of monocytes in patients with COVID‐19 pneumonia	131
Blood‐based biomarkers for Alzheimer's disease	127
SARS‐CoV‐2 outbreak investigation in a German meat processing plant	123
The rapidly evolving view of lysosomal storage diseases	121
COVID ‐19: lambda interferon against viral load and hyperinflammation	109
Mechanisms of small cell lung cancer metastasis	105
Targeting cardiac fibrosis in heart failure with preserved ejection fraction: mirage or miracle?	103
Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19	100
Rationale for targeting complement in COVID‐19	99
Soluble P‐tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau	92
NAD + homeostasis in human health and disease	90
High‐resolution serum proteome trajectories in COVID‐19 reveal patient‐specific seroconversion	88
Urinary proteome profiling for stratifying patients with familial Parkinson’s disease	83
A Parkinson's disease Circ RNA s Resource reveals a link between circ SLC 8A1 and oxidative stress	83
Is BCG vaccination causally related to reduced COVID‐19 mortality?	81
Human soluble ACE2 improves the effect of remdesivir in SARS‐CoV‐2 infection	81
Hydroxychloroquine in rheumatic autoimmune disorders and beyond	79
The ups and downs of caloric restriction and fasting: from molecular effects to clinical application	79

Innovations, challenges, and minimal information for standardization of humanized mice	79
Neurofilaments in spinocerebellar ataxia type 3: blood biomarkers at the preataxic and ataxic stage in humans and mice	75
Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity	74
Higher CSF sTREM2 and microglia activation are associated with slower rates of beta‐amyloid accumulation	71
Decreased serum level of sphingosine‐1‐phosphate: a novel predictor of clinical severity in COVID‐19	69
Fragmentation patterns and personalized sequencing of cell‐free DNA in urine and plasma of glioma patients	66
Emerging roles of ATG7 in human health and disease	65
Epithelial response to IFN‐γ promotes SARS‐CoV‐2 infection	63
A comparative analysis of remdesivir and other repurposed antivirals against SARS‐CoV‐2	60
Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer	60
Novel AAV capsids for intravitreal gene therapy of photoreceptor disorders	60
Improvement of islet transplantation by the fusion of islet cells with functional blood vessels	58
Tau PET correlates with different Alzheimer’s disease‐related features compared to CSF and plasma p‐tau biomarkers	57
Integrative analysis of cell state changes in lung fibrosis with peripheral protein biomarkers	55
Systemic inflammation after stroke: implications for post‐stroke comorbidities	54
Pharmacological reversal of synaptic and network pathology in human MECP2 ‐KO neurons and cortical organoids	54
Kaposiform lymphangiomatosis effectively treated with MEK inhibition	53
FAK activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer	53
SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models	52
Dual inhibition of the terminal oxidases eradicates antibiotic‐tolerant Mycobacterium tuberculosis	51
The state of the art of bispecific antibodies for treating human malignancies	50
BAM15‐mediated mitochondrial uncoupling protects against obesity and improves glycemic control	50
Mitogen‐activated protein kinase activity drives cell trajectories in colorectal cancer	49
Reprogramming of profibrotic macrophages for treatment of bleomycin‐induced pulmonary fibrosis	49
Specific associations between plasma biomarkers and postmortem amyloid plaque and tau tangle loads	47
Aducanumab: a new phase in therapeutic development for Alzheimer’s disease?	47
Inhibition of NPC1L1 disrupts adaptive responses of drug‐tolerant persister cells to chemotherapy	46
Very‐low‐carbohydrate diet enhances human T‐cell immunity through immunometabolic reprogramming	45
LAG3 is not expressed in human and murine neurons and does not modulate α‐synucleinopathies	44
Proteasome subunit PSMC3 variants cause neurosensory syndrome combining deafness and cataract due to proteotoxic stress	43
A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea	43
Psoriatic skin inflammation is promoted by c‐Jun/AP‐1‐dependent CCL2 and IL‐23 expression in dendritic cells	42
Humanized COVID‐19 decoy antibody effectively blocks viral entry and prevents SARS‐CoV‐2 infection	42
Vegan diet in young children remodels metabolism and challenges the statuses of essential nutrients	42
Targeted attenuation of elevated histone marks at SNCA alleviates α‐synuclein in Parkinson's disease	42
FBXL 4 deficiency increases mitochondrial removal by autophagy	42
Monocytopenia, monocyte morphological anomalies and hyperinflammation characterise severe COVID ‐19 in type 2 diabetes	41
Fate and propagation of endogenously formed Tau aggregates in neuronal cells	40
Blocking interaction between SHP2 and PD‐1 denotes a novel opportunity for developing PD‐1 inhibitors	39
LSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma	39
Pathomechanisms and biomarkers in facioscapulohumeral muscular dystrophy: roles of DUX4 and PAX7	39
A novel P2X2‐dependent purinergic mechanism of enteric gliosis in intestinal inflammation	39
Neonatal AAV gene therapy rescues hearing in a mouse model of SYNE4 deafness	39
Bacterial lysis, autophagy and innate immune responses during adjunctive phage therapy in a child	38
Disease‐specific phenotypes in iPSC ‐derived neural stem cells with POLG mutations	37
High‐throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts	37
Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation	36
Attenuation of clinical and immunological outcomes during SARS‐CoV‐2 infection by ivermectin	36
Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper‐IgM syndrome	35
Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors	35

The global emergence of a novel Streptococcus suis clade associated with human infections	35
Asymptomatic COVID‐19: disease tolerance with efficient anti‐viral immunity against SARS‐CoV‐2	35
IL ‐10 producing type 2 innate lymphoid cells prolong islet allograft survival	34
Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix‐mediated tumor cell adaptation and tolerance to BRAF‐targeted therapy in melanoma	33
COVID ‐19 pandemic‐related lockdown: response time is more important than its strictness	33
SATB2 drives glioblastoma growth by recruiting CBP to promote FOXM1 expression in glioma stem cells	33
Dietary magnesium supplementation improves lifespan in a mouse model of progeria	33
A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy	33
Development of a small molecule that corrects misfolding and increases secretion of Z α 1 ‐antitrypsin	33
Seasonality of influenza and other respiratory viruses	32
Predicting infectivity: comparing four PCR‐based assays to detect culturable SARS‐CoV‐2 in clinical samples	32
The prospects for the SARS ‐CoV‐2 pandemic in Africa	32
Clinical grade ACE2 as a universal agent to block SARS‐CoV ‐2 variants	32
Ketone body oxidation increases cardiac endothelial cell proliferation	32
Glycolysis downregulation is a hallmark of HIV‐1 latency and sensitizes infected cells to oxidative stress	32
‘All In’: a pragmatic framework for COVID‐19 testing and action on a global scale	32
Flow cytometry multiplexed method for the detection of neutralizing human antibodies to the native SARS‐CoV‐2 spike protein	31
Biological foundations of successful bacteriophage therapy	31
Deletions in CWH43 cause idiopathic normal pressure hydrocephalus	31
Attenuated CSF‐1R signalling drives cerebrovascular pathology	31
The mutational landscape of the SCAN ‐B real‐world primary breast cancer transcriptome	31
A microRNA signature that correlates with cognition and is a target against cognitive decline	31
Cystatin B is essential for proliferation and interneuron migration in individuals with EPM 1 epilepsy	31
Biofabricating murine and human myo‐substitutes for rapid volumetric muscle loss restoration	30
PI 3‐kinase delta enhances axonal PIP 3 to support axon regeneration in the adult CNS	30
BNT162b2 vaccine induces antibody release in saliva: a possible role for mucosal viral protection?	30
Quantitative imaging of RAD51 expression as a marker of platinum resistance in ovarian cancer	30
Decreased memory B cell frequencies in COVID‐19 delta variant vaccine breakthrough infection	30
P‐tau235: a novel biomarker for staging preclinical Alzheimer’s disease	30
Glufosinate constrains synchronous and metachronous metastasis by promoting anti‐tumor macrophages	29
Targeting prominin2 transcription to overcome ferroptosis resistance in cancer	29
μLED‐based optical cochlear implants for spectrally selective activation of the auditory nerve	29
Cellular dynamics of myogenic cell migration: molecular mechanisms and implications for skeletal muscle cell therapies	29
Biallelic mutations in MOS cause female infertility characterized by human early embryonic arrest and fragmentation	29
Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype	28
Tenascin‐C immobilizes infiltrating T lymphocytes through CXCL12 promoting breast cancer progression	28
Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis	28
A thiol‐bound drug reservoir enhances APR‐246‐induced mutant p53 tumor cell death	28
Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons	28
A novel platform for attenuating immune hyperactivity using EXO‐CD24 in COVID‐19 and beyond	28
The NFIB‐ERO1A axis promotes breast cancer metastatic colonization of disseminated tumour cells	28
Feed‐forward loops between metastatic cancer cells and their microenvironment—the stage of escalation	28
SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function	27
Glomerular endothelial cell senescence drives age‐related kidney disease through PAI‐1	27
A Parkinson’s disease CircRNAs Resource reveals a link between circSLC8A1 and oxidative stress	27
The immune suppressive microenvironment affects efficacy of radio‐immunotherapy in brain metastasis	27
Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1	27
Inhibition of Aurora Kinase B attenuates fibroblast activation and pulmonary fibrosis	27
An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV ‐2	26
A combination of two human monoclonal antibodies cures symptomatic rabies	26
WNT inhibition creates a BRCA‐like state in Wnt‐addicted cancer	26
STIM1‐mediated calcium influx controls antifungal immunity and the metabolic function of non‐pathogenic Th17 cells	26
A siRNA targets and inhibits a broad range of SARS‐CoV‐2 infections including Delta variant	26
Neuron type‐specific increase in lamin B1 contributes to nuclear dysfunction in Huntington’s disease	26
Modeling genetic epileptic encephalopathies using brain organoids	26
Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1‐dependent TFEB/TFE3 regulation	26
An IgG‐based bispecific antibody for improved dual targeting in PSMA‐positive cancer	26
SARS‐CoV‐2 worldwide replication drives rapid rise and selection of mutations across the viral genome: a time‐course study – potential challenge for vaccines and therapies	25
HDAC1 dysregulation induces aberrant cell cycle and DNA damage in progress of TDP‐43 proteinopathies	25
Modulation of intrinsic inhibitory checkpoints using nano‐carriers to unleash NK cell activity	25
MECP2 mutations affect ciliogenesis: a novel perspective for Rett syndrome and related disorders	24
Brain cross‐protection against SARS‐CoV‐2 variants by a lentiviral vaccine in new transgenic mice	24
Cysteamine–bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis	23
Interaction between the inflammasome and commensal microorganisms in gastrointestinal health and disease	23
Aged lipid‐laden microglia display impaired responses to stroke	23
Contraceptive progestins with androgenic properties stimulate breast epithelial cell proliferation	23
Utility of red‐light ultrafast optogenetic stimulation of the auditory pathway	23
Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer	23
Antioxidant nanozyme counteracts HIV‐1 by modulating intracellular redox potential	22
Synaptic disruption and CREB‐regulated transcription are restored by K + channel blockers in ALS	22
MicroRNA‐574 regulates FAM210A expression and influences pathological cardiac remodeling	21
Ang2 inhibitors and Tie2 activators: potential therapeutics in perioperative treatment of early stage cancer	21
A nontyphoidal Salmonella serovar domestication accompanying enhanced niche adaptation	21
Non‐genetic heterogeneity, altered cell fate and differentiation therapy	21
Aberrant upregulation of CaSR promotes pathological new bone formation in ankylosing spondylitis	21
Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component	21
RIPK1‐mediated immunogenic cell death promotes anti‐tumour immunity against soft‐tissue sarcoma	21
Diagnostic biomarkers for active tuberculosis: progress and challenges	20
Dependence receptors: new targets for cancer therapy	20
Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes	20

Autopsy registry can facilitate COVID ‐19 research	20
Metronomic chemotherapy offsets HIFα induction upon maximum‐tolerated dose in metastatic cancers	20
Muscle‐directed gene therapy corrects Pompe disease and uncovers species‐specific GAA immunogenicity	19
Mannose receptor‐derived peptides neutralize pore‐forming toxins and reduce inflammation and development of pneumococcal disease	19
Targeting netrin‐3 in small cell lung cancer and neuroblastoma	19
Comparative intravital imaging of human and rodent malaria sporozoites reveals the skin is not a species‐specific barrier	19
SRSF protein kinase 1 modulates RAN translation and suppresses CGG repeat toxicity	19
Identification of treatment‐induced vulnerabilities in pancreatic cancer patients using functional model systems	19
Advances in high‐throughput mass spectrometry in drug discovery	18
Systemic CD4 immunity: A powerful clinical biomarker for PD‐L1/PD‐1 immunotherapy	18
Targeted genome editingin vivocorrects aDmdduplication restoring wild‐type dystrophin expression	18
TPC2 rescues lysosomal storage in mucolipidosis type IV , Niemann–Pick type C1,	18
Compound heterozygous variants in OTULIN are associated with fulminant atypical late‐onset ORAS	18
Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling	18
Gene therapy in the putamen for curing AADC deficiency and Parkinson's disease	18
Strengthening vaccines and medicines manufacturing capabilities in Africa: challenges and perspectives	18
Paneth cells as the cornerstones of intestinal and organismal health: a primer	18
Lactate dehydrogenases promote glioblastoma growth and invasion via a metabolic symbiosis	18
Loss of PIKfyve drives the spongiform degeneration in prion diseases	18
Mycobacterium tuberculosis Rv2626c‐derived peptide as a therapeutic agent for sepsis	18
Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease	17
Drug‐like sphingolipid SH‐BC‐893 opposes ceramide‐induced mitochondrial fission and corrects diet‐induced obesity	17
Peripheral blood transcriptome profiling enables monitoring disease progression in dystrophic mice and patients	17
Bi‐allelic pathogenic variants in NDUFC2 cause early‐onset Leigh syndrome and stalled biogenesis of complex I	17
The onset of PI3K‐related vascular malformations occurs during angiogenesis and is prevented by the AKT inhibitor miransertib	17
MYH 3‐associated distal arthrogryposis zebrafish model is normalized with para‐aminoblebbistatin	17
TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT	17
Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson–Gilford Progeria	17
Nanobodies dismantle post‐pyroptotic ASC specks and counteract inflammation in vivo	17
miR‐33 in cardiometabolic diseases: lessons learned from novel animal models and approaches	16
Pro‐inflammatory immunity supports fibrosis advancement in epidermolysis bullosa: intervention with Ang‐(1‐7)	16
Promoters of ASCL1‐ and NEUROD1‐dependent genes are specific targets of lurbinectedin in SCLC cells	16
Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy	16
miR‐9 modulates and predicts the response to radiotherapy and EGFR inhibition in HNSCC	16
Inhibiting parasite proliferation using a rationally designed anti‐tubulin agent	16
Combined targeting of G protein‐coupled receptor and EGF receptor signaling overcomes resistance to PI 3K pathway inhibitors in	16
Oxidized LDL‐dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy	16
Can artificial intelligence identify effective COVID ‐19 therapies?	15
The respiratory syncytial virus (RSV) prefusion F‐protein functional antibody repertoire in adult healthy donors	15
Bi‐allelic VPS16 variants limit HOPS/CORVET levels and cause a mucopolysaccharidosis‐like disease	15
When fat meets the gut—focus on intestinal lipid handling in metabolic health and disease	15
The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity	15
SARS‐CoV‐2 spike spurs intestinal inflammation via VEGF production in enterocytes	15
CDK7/12/13 inhibition targets an oscillating leukemia stem cell network and synergizes with venetoclax in acute myeloid leukemia	15
Uncovering a conserved vulnerability site in SARS‐CoV‐2 by a human antibody	15
CRISPR screens identify tumor‐promoting genes conferring melanoma cell plasticity and resistance	15
Epigenetic gene expression links heart failure to memory impairment	15
ALX 1‐ related frontonasal dysplasia results from defective neural crest cell development and migration	15
ANGPTL 4 exacerbates pancreatitis by augmenting acinar cell injury through upregulation of C5a	15
Depressive patient‐derived GABA interneurons reveal abnormal neural activity associated with HTR2C	15
Protective anti‐prion antibodies in human immunoglobulin repertoires	15
PM2.5 promotes lung cancer progression through activation of the AhR‐TMPRSS2‐IL18 pathway	14
Upfront admixing antibodies and EGFR inhibitors preempts sequential treatments in lung cancer models	14
Machine learning suggests polygenic risk for cognitive dysfunction in amyotrophic lateral sclerosis	14
Is there an unmet medical need for improved hearing restoration?	14
sTREM2 is associated with amyloid‐related p‐tau increases and glucose hypermetabolism in Alzheimer's disease	14
Beclin‐1‐mediated activation of autophagy improves proximal and distal urea cycle disorders	14
Alleviation of a polyglucosan storage disorder by enhancement of autophagic glycogen catabolism	14
In vitro and in vivo drug screens of tumor cells identify novel therapies for high‐risk child cancer	14
Targeted stabilization of Munc18‐1 function via pharmacological chaperones	14
A novel phosphocholine‐mimetic inhibits a pro‐inflammatory conformational change in C‐reactive protein	14
A spoonful of L‐fucose—an efficient therapy for GFUS‐CDG, a new glycosylation disorder	13
Store‐operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease	13
The genetic regulation of protein expression in cerebrospinal fluid	13
Blocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T‐cell lymphoma	13
Zinc inhibits lethal inflammatory shock by preventing microbe‐induced interferon signature in intestinal epithelium	13
AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model	13
Early disruption of photoreceptor cell architecture and loss of vision in a humanized pig model of usher syndromes	13
Pdia4 regulates β‐cell pathogenesis in diabetes: molecular mechanism and targeted therapy	13
Disrupting metformin adaptation of liver cancer cells by targeting the TOMM34/ATP5B axis	13
Targetable Brg1‐CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking	13
Systemically targeted cancer immunotherapy and gene delivery using transmorphic particles	13
Malaria parasites differentially sense environmental elasticity during transmission	13
THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer	13
Anti‐tumoural activity of the G‐quadruplex ligand pyridostatin against BRCA1/2‐deficient tumours	13
Targeted delivery of a phosphoinositide 3‐kinase γ inhibitor to restore organ function in sepsis	13
Myeloid cell‐based delivery of IFN‐γ reprograms the leukemia microenvironment and induces anti‐tumoral immune responses	13
Protein Kinase D2 drives chylomicron‐mediated lipid transport in the intestine and promotes obesity	12
Molecular mechanisms for the modulation of blood pressure and potassium homeostasis by the distal convoluted tubule	12
Correction of oxidative stress enhances enzyme replacement therapy in Pompe disease	12
Autocrine INSL 5 promotes tumor progression and glycolysis via activation of STAT 5 signaling	12
Striatal infusion of cholesterol promotes dose‐dependent behavioral benefits and exerts disease‐modifying effects in Huntington's disease mice	12
CD38‐NADase is a new major contributor to Duchenne muscular dystrophic phenotype	12
Blockade of the pro‐fibrotic reaction mediated by the miR‐143/‐145 cluster enhances the responses to targeted therapy in melanoma	12
Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling	12
BCAA insufficiency leads to premature ovarian insufficiency via ceramide‐induced elevation of ROS	12
LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy	12
SARS‐CoV ‐2 spike protein enhances MAP4K3 / GLK ‐induced ACE2 stability	12
Intercepting IRE1 kinase‐FMRP signaling prevents atherosclerosis progression	12
LRP8‐mediated selenocysteine uptake is a targetable vulnerability in MYCN‐amplified neuroblastoma	12
KRAS signaling in malignant pleural mesothelioma	12
Unexpected PD‐L1 immune evasion mechanism in TNBC, ovarian, and other solid tumors by DR5 agonist antibodies	12
Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism	12
Chromatin accessibility landscape of pediatric T‐lymphoblastic leukemia and human T‐cell precursors	12
Circulating proteomic panels for risk stratification of intracranial aneurysm and its rupture	12