OOIR: Observatory of International Research

Papers

(The median citation count of EMBO Molecular Medicine is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Whole‐brain microscopy reveals distinct temporal and spatial efficacy of anti‐Aβ therapies	186
Circulating proteomic panels for risk stratification of intracranial aneurysm and its rupture	152
THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer	104
Autologous, lentivirus‐modified, T‐rapa cell “micropharmacies” for lysosomal storage disorders	85
A preclinical model of peripheral T‐cell lymphoma GATA3 reveals DNA damage response pathway vulnerability	84
Targeting the Leukemic stem cell protein machinery by inhibition of mitochondrial pyrimidine synthesis	81
IQCN disruption causes fertilization failure and male infertility due to manchette assembly defect	76
Targetable Brg1‐CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking	76
When fat meets the gut—focus on intestinal lipid handling in metabolic health and disease	67
Activation of the integrated stress response is a vulnerability for multidrug‐resistant FBXW7 ‐deficient cells	66
HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy	66
Depressive patient‐derived GABA interneurons reveal abnormal neural activity associated with HTR2C	60
Targeting conformational changes in C‐reactive protein to inhibit pro‐inflammatory actions	59
TFEB and TFE3 drive kidney cystogenesis and tumorigenesis	59
Elongator and the role of its subcomplexes in human diseases	58
Eosinophil‐derived IL ‐4 is necessary to establish the inflammatory structure in innate inflammation	55
Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain	53
ASO targeting RBM3 temperature‐controlled poison exon splicing prevents neurodegeneration in vi	52
Metformin rescues migratory deficits of cells derived from patients with periventricular heterotopia	52
Identification of treatment‐induced vulnerabilities in pancreatic cancer patients using functional model systems	51
Diagnostic biomarkers for active tuberculosis: progress and challenges	51
Systemic inflammation after stroke: implications for post‐stroke comorbidities	50
Single‐cell profiling of muscle‐infiltrating T cells in idiopathic inflammatory myopathies	47
Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy	44
Spleen tyrosine kinase mediates innate and adaptive immune crosstalk in SARS‐CoV‐2 mRNA vaccination	43

Looking at a baby's heart through the lens of the mother's blood	43
Shear stress control of vascular leaks and atheromas through Tie2 activation by VE‐PTP sequestration	43
Optimizing the Cas13 antiviral train: cargo and delivery	43
Nerve regeneration by interferon intervention in aging brain	43
Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model	43
Functions of double‐negative B cells in autoimmune diseases, infections, and cancers	43
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy	42
Macrophage colony‐stimulating factor as a weapon against cytomegalovirus	41
In vivo single‐cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection	40
ALX1 ‐related frontonasal dysplasia results from defective neural crest cell development and migration	40
Blocking STAT3 /5 through direct or upstream kinase targeting in leukemic cutaneous T‐cell lymphoma	40
A type IV Autotaxin inhibitor ameliorates acute liver injury and nonalcoholic steatohepatitis	40
Advances in high‐throughput mass spectrometry in drug discovery	40
An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV	39
TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using	39
Immuno(T)herapy for age‐related diseases	38
Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease	38
Sex differences and risk factors for bleeding in Alagille syndrome	38
The human host response to monkeypox infection: a proteomic case series study	37
Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation	37
AAV induces hepatic necroptosis and carcinoma in diabetic and obese mice dependent on Pebp1 pathway	37
Elucidating effects of environmental exposure using human‐induced pluripotent stem cell disease modeling	35
A novel platform for attenuating immune hyperactivity using EXO‐CD24 in COVID‐19 and beyond	35
The molecular biology of peritoneal metastatic disease	35
X‐linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL	34
IL ‐27 produced during acute malaria infection regulates Plasmodium ‐specific memory CD4	34
Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis	33
Trichothiodystrophy‐associated MPLKIP maintains DBR1 levels for proper lariat debranching and ecto	33
Nanobody‐mediated complement activation to kill HIV ‐infected cells	33
Systemic gene therapy rescues retinal dysfunction and hearing loss in a model of Norrie disease	33
Patient‐ and xenograft‐derived organoids recapitulate pediatric brain tumor features and patient treatments	32
miR ‐181a/b downregulation: a mutation‐independent therapeutic approach for inherited retinal diseases	32
Full eradication of pre‐clinical human papilloma virus‐induced tumors by a lentiviral vaccine	32
Liver gene therapy with intein‐mediated F8 trans ‐splicing corrects mouse haemophilia A	32
Development of allogeneic iPS cell‐based therapy: from bench to bedside	31
Answer to Gerber et al. “ Autosomal recessive pathogenic MSTO1	31
NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5	31
TAPT1 —at the crossroads of extracellular matrix and signaling in Osteogenesis imperfecta	31
A progeroid syndrome caused by a deep intronic variant in TAPT1 is revealed by RNA/SI‐NET sequencing	30
Dual IRE1 RNase functions dictate glioblastoma development	30
Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in SARS‐CoV ‐2 mouse models of infection	30
AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model	29
Molecular and functional properties of human Plasmodium falciparum CSP C‐terminus antibodies	29
A clinically compatible drug‐screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis	29
Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcoma	29
Nuclear PRMT5 is a biomarker of sensitivity to tamoxifen in ERα ⁺ b	29
Lack of the human choline transporter‐like protein SLC44A2 causes hearing impairment and a rare red blood phenotype	28
Transfixed by transgenics: how pathology assumptions are slowing progress in Alzheimer's disease and related dementia research	28
RNAi to treat SARS‐CoV‐2—variant proofing the next generation of therapies	28
AAV‐delivered diacylglycerol kinase DGKk achieves long‐term rescue of fragile X syndrome mouse model	27

MSTO1 is a cytoplasmic pro‐mitochondrial fusion protein, whose mutation induces myopathy and ataxia in humans	27
COVID‐19 vaccination, time for a second breath?	27
Long non‐coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling	27
A whole‐genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors	25
Targeting the liver to treat the eye	25
Repurposing immunosuppressants for antileukemia therapy	25
The Sec61 translocon is a therapeutic vulnerability in multiple myeloma	25
Interactions between BRD4S, LOXL2, and MED1 drive cell cycle transcription in triple‐negative breast cancer	25
Disrupting metformin adaptation of liver cancer cells by targeting the TOMM34 / ATP5B axis	25
Intestinal Apc ‐inactivation induces HSP25 dependency	24
Epigenetic silencing of SALL2 confers tamoxifen resistance in breast cancer	24
Therapeutic activation of endothelial sphingosine‐1‐phosphate receptor 1 by chaperone‐bound S1P suppresses proliferative retinal neovascularization	24
Clinical grade ACE2 as a universal agent to block SARS‐CoV ‐2 variants	24
mAb therapy controls CNS‐resident lyssavirus infection via a CD4 T cell‐dependent mechanism	24
Alteration of microbiota antibody‐mediated immune selection contributes to dysbiosis in inflammatory bowel diseases	24
Blockade of the pro‐fibrotic reaction mediated by the miR‐143/‐145 cluster enhances the responses to targeted therapy in melanoma	24
Seasonality of influenza and other respiratory viruses	23
A nontyphoidal Salmonella serovar domestication accompanying enhanced niche adaptation	23
Propionate reinforces epithelial identity and reduces aggressiveness of lung carcinoma	23
Anti‐tumoural activity of the G‐quadruplex ligand pyridostatin against BRCA1/2‐deficient tumours	23
β‐Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T‐cell acute lymphoblastic leukemia	23
DGAT inhibition at the post‐absorptive phase reduces plasma FA by increasing FA	23
Early 5‐HT ₆ receptor blockade prevents symptom onset in a model of adol	22
Antagonizing microRNA ‐19a/b augments PTH anabolic action and restores bone mass in osteoporosis i	22
Adoptive T cell therapy cures mice from active hemophagocytic lymphohistiocytosis (HLH)	21
Liver‐directed gene therapy for ornithine aminotransferase deficiency	21
A catalog of numerical centrosome defects in epithelial ovarian cancers	21
IMPDH inhibition activates TLR‐VCAM1 pathway and suppresses the development of MLL‐fusion leukemia	21
Long non‐coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling	21
Interferon regulates neural stem cell function at all ages by orchestrating mTOR and cell cycle	21
Cingulin regulates hair cell cuticular plate morphology and is required for hearing in human and mouse	21
Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ‐secretase activity	20
iPSC ‐based modeling of THD recapitulates disease phenotypes and reveals neuronal malformation	20
Maternal diet and gut microbiome composition modulate early‐life immune development	20
A high‐resolution 3D atlas of the spectrum of tuberculous and COVID ‐19 lung lesions	20
Targeting CRAC channels in inflammatory bowel disease	19
Sensitivity towards HDAC inhibition is associated with RTK / MAPK	19
Tumor‐associated macrophages‐educated reparative macrophages promote diabetic wound healing	19
Oxidative stress enhances the therapeutic action of a respiratory inhibitor in MYC ‐driven lymphoma	19
Enhancement of efferocytosis through biased FPR2 signaling attenuates intestinal inflammation	19
Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons	19
Immunotherapy targeting isoDGR ‐protein damage extends lifespan in a mouse model of protein deamidation	19
Can THEM6 targeting stop resistance to prostate cancer treatment?	19
Dual IRE1 RNase functions dictate glioblastoma development	18
Microbiota dysbiosis influences immune system and muscle pathophysiology of dystrophin‐deficient mice	18
Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability	18
Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy	18
Graft conditioning with fluticasone propionate reduces graft‐versus‐host disease upon allogeneic hematopoietic cell transplantation in mice	17
Propylene glycol inactivates respiratory viruses and prevents airborne transmission	17
Genetically modified macrophages accelerate myelin repair	17
Mutated axon guidance gene PLXNB2 sustains growth and invasiveness of stem cells isolated from can	17
Single‐cell transcriptomics reveals a senescence‐associated IL ‐6/ CCR6 axis driving radiodermatit	17
Caspase‐8 in endothelial cells maintains gut homeostasis and prevents small bowel inflammation in mice	17
Intratumoral co‐injection of NK cells and NKG2A ‐neutralizing monoclonal antibodies	17
Artificial sweeteners inhibit multidrug‐resistant pathogen growth and potentiate antibiotic activity	17
Neuropilin‐1 ( NRP1 ) expression distinguishes self‐reactive helper T cells in systemic autoimmune disease	16
Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia	16
LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease	16
S1P defects cause a new entity of cataract, alopecia, oral mucosal disorder, and psoriasis‐like syndrome	16
Allelic effects on uromodulin aggregates drive autosomal dominant tubulointerstitial kidney disease	16
Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy	15
When dysbiosis meets dystrophy: an unwanted gut‐muscle connection	15
Lifting the iron curtain of vision	15
Microbial metabolites in chronic heart failure and its common comorbidities	15
FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder	15
In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues	15
Acquired immunity against SARS‐CoV‐2 infection and vaccination	15
The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity	15
Aged lipid‐laden microglia display impaired responses to stroke	15