OOIR: Observatory of International Research

Papers

(The median citation count of EMBO Molecular Medicine is 17. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Whole‐brain microscopy reveals distinct temporal and spatial efficacy of anti‐Aβ therapies	222
IQCN disruption causes fertilization failure and male infertility due to manchette assembly defect	180
Targeting the Leukemic stem cell protein machinery by inhibition of mitochondrial pyrimidine synthesis	117
Targeting conformational changes in C‐reactive protein to inhibit pro‐inflammatory actions	97
HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy	89
Activation of the integrated stress response is a vulnerability for multidrug‐resistant FBXW7 ‐deficient cells	86
Elongator and the role of its subcomplexes in human diseases	78
A preclinical model of peripheral T‐cell lymphoma GATA3 reveals DNA damage response pathway vulnerability	74
Depressive patient‐derived GABA interneurons reveal abnormal neural activity associated with HTR2C	73
Targetable Brg1‐CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking	64
TFEB and TFE3 drive kidney cystogenesis and tumorigenesis	63
Metformin rescues migratory deficits of cells derived from patients with periventricular heterotopia	63
ASO targeting RBM3 temperature‐controlled poison exon splicing prevents neurodegeneration in vi	62
Diagnostic biomarkers for active tuberculosis: progress and challenges	61
Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain	60
Systemic inflammation after stroke: implications for post‐stroke comorbidities	58
Eosinophil‐derived IL ‐4 is necessary to establish the inflammatory structure in innate inflammation	57
Nerve regeneration by interferon intervention in aging brain	53
Single‐cell profiling of muscle‐infiltrating T cells in idiopathic inflammatory myopathies	51
Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy	51
Shear stress control of vascular leaks and atheromas through Tie2 activation by VE‐PTP sequestration	50
Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model	49
Spleen tyrosine kinase mediates innate and adaptive immune crosstalk in SARS‐CoV‐2 mRNA vaccination	49
Looking at a baby's heart through the lens of the mother's blood	48
Functions of double‐negative B cells in autoimmune diseases, infections, and cancers	48

Optimizing the Cas13 antiviral train: cargo and delivery	47
ALX1 ‐related frontonasal dysplasia results from defective neural crest cell development and migration	47
Macrophage colony‐stimulating factor as a weapon against cytomegalovirus	47
TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using	46
Blocking STAT3 /5 through direct or upstream kinase targeting in leukemic cutaneous T‐cell lymphoma	45
An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV	45
In vivo single‐cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection	44
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy	43
Advances in high‐throughput mass spectrometry in drug discovery	42
Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease	41
A type IV Autotaxin inhibitor ameliorates acute liver injury and nonalcoholic steatohepatitis	41
The human host response to monkeypox infection: a proteomic case series study	40
Sex differences and risk factors for bleeding in Alagille syndrome	40
X‐linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL	39
Immuno(T)herapy for age‐related diseases	38
Elucidating effects of environmental exposure using human‐induced pluripotent stem cell disease modeling	38
The molecular biology of peritoneal metastatic disease	37
A novel platform for attenuating immune hyperactivity using EXO‐CD24 in COVID‐19 and beyond	37
Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation	36
AAV induces hepatic necroptosis and carcinoma in diabetic and obese mice dependent on Pebp1 pathway	36
Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis	35
Trichothiodystrophy‐associated MPLKIP maintains DBR1 levels for proper lariat debranching and ecto	35
Liver gene therapy with intein‐mediated F8 trans ‐splicing corrects mouse haemophilia A	35
Nanobody‐mediated complement activation to kill HIV ‐infected cells	33
IL ‐27 produced during acute malaria infection regulates Plasmodium ‐specific memory CD4	33
miR ‐181a/b downregulation: a mutation‐independent therapeutic approach for inherited retinal diseases	33
Systemic gene therapy rescues retinal dysfunction and hearing loss in a model of Norrie disease	32
Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcoma	32
Answer to Gerber et al. “ Autosomal recessive pathogenic MSTO1	31
Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in SARS‐CoV ‐2 mouse models of infection	31
TAPT1 —at the crossroads of extracellular matrix and signaling in Osteogenesis imperfecta	31
Full eradication of pre‐clinical human papilloma virus‐induced tumors by a lentiviral vaccine	31
A progeroid syndrome caused by a deep intronic variant in TAPT1 is revealed by RNA/SI‐NET sequencing	30
Nuclear PRMT5 is a biomarker of sensitivity to tamoxifen in ERα ⁺ b	30
Development of allogeneic iPS cell‐based therapy: from bench to bedside	30
Molecular and functional properties of human Plasmodium falciparum CSP C‐terminus antibodies	29
NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5	29
Lack of the human choline transporter‐like protein SLC44A2 causes hearing impairment and a rare red blood phenotype	28
Patient‐ and xenograft‐derived organoids recapitulate pediatric brain tumor features and patient treatments	28
Disrupting metformin adaptation of liver cancer cells by targeting the TOMM34 / ATP5B axis	27
MSTO1 is a cytoplasmic pro‐mitochondrial fusion protein, whose mutation induces myopathy and ataxia in humans	27
Transfixed by transgenics: how pathology assumptions are slowing progress in Alzheimer's disease and related dementia research	27
A whole‐genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors	26
Repurposing immunosuppressants for antileukemia therapy	26
Targeting the liver to treat the eye	26
mAb therapy controls CNS‐resident lyssavirus infection via a CD4 T cell‐dependent mechanism	26
A nontyphoidal Salmonella serovar domestication accompanying enhanced niche adaptation	25
DGAT inhibition at the post‐absorptive phase reduces plasma FA by increasing FA	25
Antagonizing microRNA ‐19a/b augments PTH anabolic action and restores bone mass in osteoporosis i	25
Therapeutic activation of endothelial sphingosine‐1‐phosphate receptor 1 by chaperone‐bound S1P suppresses proliferative retinal neovascularization	25

Clinical grade ACE2 as a universal agent to block SARS‐CoV ‐2 variants	25
β‐Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T‐cell acute lymphoblastic leukemia	25
Long non‐coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling	24
Intestinal Apc ‐inactivation induces HSP25 dependency	24
Propionate reinforces epithelial identity and reduces aggressiveness of lung carcinoma	24
Early 5‐HT ₆ receptor blockade prevents symptom onset in a model of adol	24
Alteration of microbiota antibody‐mediated immune selection contributes to dysbiosis in inflammatory bowel diseases	24
Liver‐directed gene therapy for ornithine aminotransferase deficiency	24
Adoptive T cell therapy cures mice from active hemophagocytic lymphohistiocytosis (HLH)	24
Interactions between BRD4S, LOXL2, and MED1 drive cell cycle transcription in triple‐negative breast cancer	24
Cingulin regulates hair cell cuticular plate morphology and is required for hearing in human and mouse	23
Interferon regulates neural stem cell function at all ages by orchestrating mTOR and cell cycle	23
Maternal diet and gut microbiome composition modulate early‐life immune development	22
A catalog of numerical centrosome defects in epithelial ovarian cancers	22
IMPDH inhibition activates TLR‐VCAM1 pathway and suppresses the development of MLL‐fusion leukemia	22
Enhancement of efferocytosis through biased FPR2 signaling attenuates intestinal inflammation	21
iPSC ‐based modeling of THD recapitulates disease phenotypes and reveals neuronal malformation	21
A high‐resolution 3D atlas of the spectrum of tuberculous and COVID ‐19 lung lesions	21
Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ‐secretase activity	21
Tumor‐associated macrophages‐educated reparative macrophages promote diabetic wound healing	21
Oxidative stress enhances the therapeutic action of a respiratory inhibitor in MYC ‐driven lymphoma	20
Immunotherapy targeting isoDGR ‐protein damage extends lifespan in a mouse model of protein deamidation	20
Sensitivity towards HDAC inhibition is associated with RTK / MAPK	20
Microbiota dysbiosis influences immune system and muscle pathophysiology of dystrophin‐deficient mice	20
Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy	19
Dual IRE1 RNase functions dictate glioblastoma development	19
Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability	19
Artificial sweeteners inhibit multidrug‐resistant pathogen growth and potentiate antibiotic activity	19
Graft conditioning with fluticasone propionate reduces graft‐versus‐host disease upon allogeneic hematopoietic cell transplantation in mice	19
Targeting CRAC channels in inflammatory bowel disease	19
Single‐cell transcriptomics reveals a senescence‐associated IL ‐6/ CCR6 axis driving radiodermatit	19
Mutated axon guidance gene PLXNB2 sustains growth and invasiveness of stem cells isolated from can	19
Propylene glycol inactivates respiratory viruses and prevents airborne transmission	18
Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia	18
Caspase‐8 in endothelial cells maintains gut homeostasis and prevents small bowel inflammation in mice	18
Genetically modified macrophages accelerate myelin repair	18
LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease	18
Intratumoral co‐injection of NK cells and NKG2A ‐neutralizing monoclonal antibodies	17
Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy	17
Allelic effects on uromodulin aggregates drive autosomal dominant tubulointerstitial kidney disease	17
When dysbiosis meets dystrophy: an unwanted gut‐muscle connection	17
Neuropilin‐1 ( NRP1 ) expression distinguishes self‐reactive helper T cells in systemic autoimmune disease	17
Acquired immunity against SARS‐CoV‐2 infection and vaccination	17