EMBO Molecular Medicine

Article	Citations
Autologous, lentivirus‐modified, T‐rapa cell “micropharmacies” for lysosomal storage disorders	353
Circulating proteomic panels for risk stratification of intracranial aneurysm and its rupture	239
THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer	144
Whole‐brain microscopy reveals distinct temporal and spatial efficacy of anti‐Aβ therapies	142
Targeting the Leukemic stem cell protein machinery by inhibition of mitochondrial pyrimidine synthesis	132
TFEB and TFE3 drive kidney cystogenesis and tumorigenesis	116
Targeting conformational changes in C‐reactive protein to inhibit pro‐inflammatory actions	96
A preclinical model of peripheral T‐cell lymphoma GATA3 reveals DNA damage response pathway vulnerability	79
Targetable Brg1‐CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking	70
IQCN disruption causes fertilization failure and male infertility due to manchette assembly defect	68
HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy	67
Activation of the integrated stress response is a vulnerability for multidrug‐resistant FBXW7 ‐deficient cells	66
Flower lose, a cell fitness marker, predicts COVID‐19 prognosis	63
The state of the art of bispecific antibodies for treating human malignancies	60
Glomerular endothelial cell senescence drives age‐related kidney disease through PAI‐1	60
When fat meets the gut—focus on intestinal lipid handling in metabolic health and disease	57
Elongator and the role of its subcomplexes in human diseases	56
Depressive patient‐derived GABA interneurons reveal abnormal neural activity associated with HTR2C	54
Metformin rescues migratory deficits of cells derived from patients with periventricular heterotopia	53
Systemic inflammation after stroke: implications for post‐stroke comorbidities	51
ASO targeting RBM3 temperature‐controlled poison exon splicing prevents neurodegeneration in vivo	51
Identification of treatment‐induced vulnerabilities in pancreatic cancer patients using functional model systems	49
Eosinophil‐derived IL ‐4 is necessary to establish the inflammatory structure in innate inflammation	49
Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain	49
Diagnostic biomarkers for active tuberculosis: progress and challenges	48

Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model	47
Spleen tyrosine kinase mediates innate and adaptive immune crosstalk in SARS‐CoV‐2 mRNA vaccination	46
Nerve regeneration by interferon intervention in aging brain	45
Single‐cell profiling of muscle‐infiltrating T cells in idiopathic inflammatory myopathies	45
Functions of double‐negative B cells in autoimmune diseases, infections, and cancers	44
Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy	44
Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer	44
Shear stress control of vascular leaks and atheromas through Tie2 activation by VE‐PTP sequestration	42
A type IV Autotaxin inhibitor ameliorates acute liver injury and nonalcoholic steatohepatitis	41
Advances in high‐throughput mass spectrometry in drug discovery	40
ALX1 ‐related frontonasal dysplasia results from defective neural crest cell development and migration	40
In vivo single‐cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection	40
Macrophage colony‐stimulating factor as a weapon against cytomegalovirus	39
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy	39
TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT	37
In vitro and in vivo drug screens of tumor cells identify novel therapies for high‐risk child cancer	37
Mining the bacterial genome to discover new antimicrobial molecules	36
Looking at a baby's heart through the lens of the mother's blood	36
Optimizing the Cas13 antiviral train: cargo and delivery	36
Blocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T‐cell lymphoma	36
Sex differences and risk factors for bleeding in Alagille syndrome	35
An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV ‐2	35
The molecular biology of peritoneal metastatic disease	35
AAV induces hepatic necroptosis and carcinoma in diabetic and obese mice dependent on Pebp1 pathway	35
Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease	35
Elucidating effects of environmental exposure using human‐induced pluripotent stem cell disease modeling	34
Deconstructing progressive inflammatory fibrosis in recessive dystrophic epidermolysis bullosa	34
X‐linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL	34
The human host response to monkeypox infection: a proteomic case series study	33
Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation	33
A novel platform for attenuating immune hyperactivity using EXO‐CD24 in COVID‐19 and beyond	33
miR ‐181a/b downregulation: a mutation‐independent therapeutic approach for inherited retinal diseases	32
Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis	32
External validity in translational biomedicine: understanding the conditions enabling the cause to have an effect	32
Liver gene therapy with intein‐mediated F8 trans ‐splicing corrects mouse haemophilia A	32
Immuno(T)herapy for age‐related diseases	32
Systemic gene therapy rescues retinal dysfunction and hearing loss in a model of Norrie disease	32
Trichothiodystrophy‐associated MPLKIP maintains DBR1 levels for proper lariat debranching and ectodermal differentiation	32
Nanobody‐mediated complement activation to kill HIV‐infected cells	31
Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis	31
IL‐27 produced during acute malaria infection regulates Plasmodium‐specific memory CD4+ T cells	31
Adaptively evolved human oral actinomyces‐sourced defensins show therapeutic potential	30
Full eradication of pre‐clinical human papilloma virus‐induced tumors by a lentiviral vaccine	29
YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis	29
A spoonful of L‐fucose—an efficient therapy for GFUS‐CDG, a new glycosylation disorder	29
Rational design of West Nile virus vaccine through large replacement of 3′ UTR with internal poly(A)	29
Answer to Gerber et al. “Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy”	29
Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in SARS‐CoV‐2 mouse models of infection	29
Alleviation of a polyglucosan storage disorder by enhancement of autophagic glycogen catabolism	29
Dual IRE1 RNase functions dictate glioblastoma development	28

AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model	28
Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcoma	28
Gene therapy in the putamen for curing AADC deficiency and Parkinson's disease	27
Patient‐ and xenograft‐derived organoids recapitulate pediatric brain tumor features and patient treatments	27
Nuclear PRMT5 is a biomarker of sensitivity to tamoxifen in ERα+ breast cancer	27
TAPT1—at the crossroads of extracellular matrix and signaling in Osteogenesis imperfecta	27
Development of allogeneic iPS cell‐based therapy: from bench to bedside	27
A progeroid syndrome caused by a deep intronic variant in TAPT1 is revealed by RNA/SI‐NET sequencing	27
AAV‐delivered diacylglycerol kinase DGKk achieves long‐term rescue of fragile X syndrome mouse model	26
SPINK6 inhibits human airway serine proteases and restricts influenza virus activation	26
NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5	26
Lack of the human choline transporter‐like protein SLC44A2 causes hearing impairment and a rare red blood phenotype	26
Molecular and functional properties of human Plasmodium falciparum CSP C‐terminus antibodies	26
Uncovering a conserved vulnerability site in SARS‐CoV‐2 by a human antibody	26
A clinically compatible drug‐screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis	26
Transfixed by transgenics: how pathology assumptions are slowing progress in Alzheimer's disease and related dementia research	25
BET1 variants establish impaired vesicular transport as a cause for muscular dystrophy with epilepsy	25
microRNAs trip down memory lane	25
RNAi to treat SARS‐CoV‐2—variant proofing the next generation of therapies	25
Long non‐coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling	24
Molecular mechanisms for the modulation of blood pressure and potassium homeostasis by the distal convoluted tubule	24
A whole‐genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors	24
Targeting the liver to treat the eye	24
Correction of oxidative stress enhances enzyme replacement therapy in Pompe disease	24
The Sec61 translocon is a therapeutic vulnerability in multiple myeloma	24
COVID‐19 vaccination, time for a second breath?	24
Disrupting metformin adaptation of liver cancer cells by targeting the TOMM34/ATP5B axis	23
β‐Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T‐cell acute lymphoblastic leukemia	23
Mitogen‐activated protein kinase activity drives cell trajectories in colorectal cancer	23
Propionate reinforces epithelial identity and reduces aggressiveness of lung carcinoma	23
MSTO1 is a cytoplasmic pro‐mitochondrial fusion protein, whose mutation induces myopathy and ataxia in humans	23
Epigenetic silencing of SALL2 confers tamoxifen resistance in breast cancer	23
Alteration of microbiota antibody‐mediated immune selection contributes to dysbiosis in inflammatory bowel diseases	23
Intestinal Apc‐inactivation induces HSP25 dependency	22
Repurposing immunosuppressants for antileukemia therapy	22
mAb therapy controls CNS‐resident lyssavirus infection via a CD4 T cell‐dependent mechanism	22
Interactions between BRD4S, LOXL2, and MED1 drive cell cycle transcription in triple‐negative breast cancer	22
Therapeutic activation of endothelial sphingosine‐1‐phosphate receptor 1 by chaperone‐bound S1P suppresses proliferative retinal neovascularization	22
Antagonizing microRNA ‐19a/b augments PTH anabolic action and restores bone mass in osteoporosis in mice	21
Blockade of the pro‐fibrotic reaction mediated by the miR‐143/‐145 cluster enhances the responses to targeted therapy in melanoma	21
DGAT inhibition at the post‐absorptive phase reduces plasma FA by increasing FA oxidation	21
Anti‐tumoural activity of the G‐quadruplex ligand pyridostatin against BRCA1/2‐deficient tumours	21
Clinical grade ACE2 as a universal agent to block SARS‐CoV ‐2 variants	21
A nontyphoidal Salmonella serovar domestication accompanying enhanced niche adaptation	21
Early 5‐HT 6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse	20
Adoptive T cell therapy cures mice from active hemophagocytic lymphohistiocytosis (HLH)	20
Long non‐coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling	20
Seasonality of influenza and other respiratory viruses	20
Inhibiting parasite proliferation using a rationally designed anti‐tubulin agent	20
A catalog of numerical centrosome defects in epithelial ovarian cancers	20
IMPDH inhibition activates TLR‐VCAM1 pathway and suppresses the development of MLL‐fusion leukemia	19
Liver‐directed gene therapy for ornithine aminotransferase deficiency	19
Dependence receptors: new targets for cancer therapy	19
Cingulin regulates hair cell cuticular plate morphology and is required for hearing in human and mouse	19
Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons	19
Maternal diet and gut microbiome composition modulate early‐life immune development	19
Interferon regulates neural stem cell function at all ages by orchestrating mTOR and cell cycle	19
Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ‐secretase activity	19
Tumor‐associated macrophages‐educated reparative macrophages promote diabetic wound healing	18
iPSC‐based modeling of THD recapitulates disease phenotypes and reveals neuronal malformation	18
Can THEM6 targeting stop resistance to prostate cancer treatment?	18
Targeting CRAC channels in inflammatory bowel disease	18
Emerging roles of ATG7 in human health and disease	18
A high‐resolution 3D atlas of the spectrum of tuberculous and COVID ‐19 lung lesions	18
Sensitivity towards HDAC inhibition is associated with RTK / MAPK pathway activation in gastric	18
Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson–Gilford Progeria	18
Oxidative stress enhances the therapeutic action of a respiratory inhibitor in MYC‐driven lymphoma	18
Dual IRE1 RNase functions dictate glioblastoma development	18
Oxidized LDL‐dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy	18
Enhancement of efferocytosis through biased FPR2 signaling attenuates intestinal inflammation	18
Myeloid cell‐based delivery of IFN‐γ reprograms the leukemia microenvironment and induces anti‐tumoral immune responses	18
Microbiota dysbiosis influences immune system and muscle pathophysiology of dystrophin‐deficient mice	18
Immunotherapy targeting isoDGR‐protein damage extends lifespan in a mouse model of protein deamidation	18
Genetically modified macrophages accelerate myelin repair	17
Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy	17
Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia	17
Propylene glycol inactivates respiratory viruses and prevents airborne transmission	17
Mutated axon guidance gene PLXNB2 sustains growth and invasiveness of stem cells isolated from cancers of unknown primary	17
Single‐cell transcriptomics reveals a senescence‐associated IL ‐6/ CCR6 axis driving radiodermatitis	17
Intratumoral co‐injection of NK cells and NKG2A‐neutralizing monoclonal antibodies	17

Caspase‐8 in endothelial cells maintains gut homeostasis and prevents small bowel inflammation in mice	17
Graft conditioning with fluticasone propionate reduces graft‐versus‐host disease upon allogeneic hematopoietic cell transplantation in mice	17
Artificial sweeteners inhibit multidrug‐resistant pathogen growth and potentiate antibiotic activity	17
Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability	17
LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease	16
Allelic effects on uromodulin aggregates drive autosomal dominant tubulointerstitial kidney disease	16
S1P defects cause a new entity of cataract, alopecia, oral mucosal disorder, and psoriasis‐like syndrome	15
Acquired immunity against SARS‐CoV‐2 infection and vaccination	15
When dysbiosis meets dystrophy: an unwanted gut‐muscle connection	15
Neuropilin‐1 ( NRP1 ) expression distinguishes self‐reactive helper T cells in systemic autoimmune disease	15
Microbial metabolites in chronic heart failure and its common comorbidities	15
Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy	15
Inhibition of O‐GlcNAcylation protects from Shiga toxin‐mediated cell injury and lethality in host	15
Synergistic effects of FGFR1 and PLK1 inhibitors target a metabolic liability in KRAS ‐mutant cancer	15
Live imaging of neolymphangiogenesis identifies acute antimetastatic roles of dsRNA mimics	14
Inhibition of NPC1L1 disrupts adaptive responses of drug‐tolerant persister cells to chemotherapy	14
Nanog maintains stemness of Lkb1 ‐deficient lung adenocarcinoma and prevents gastric differentiation	14
Sigma‐1 receptor attenuates osteoclastogenesis by promoting ER‐associated degradation of SERCA2	14
Feed‐forward loops between metastatic cancer cells and their microenvironment—the stage of escalation	14
Lifting the iron curtain of vision	14
Comparison of tumor‐informed and tumor‐naïve sequencing assays for ctDNA detection in breast cancer	14
FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder	14
In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues	14
Aged lipid‐laden microglia display impaired responses to stroke	14
Promoters of ASCL1‐ and NEUROD1‐dependent genes are specific targets of lurbinectedin in SCLC cells	14
The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity	14