EMBO Molecular Medicine

Article	Citations
Circulating proteomic panels for risk stratification of intracranial aneurysm and its rupture	251
Whole‐brain microscopy reveals distinct temporal and spatial efficacy of anti‐Aβ therapies	171
THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer	156
Autologous, lentivirus‐modified, T‐rapa cell “micropharmacies” for lysosomal storage disorders	150
Elongator and the role of its subcomplexes in human diseases	135
Targeting the Leukemic stem cell protein machinery by inhibition of mitochondrial pyrimidine synthesis	95
Targeting conformational changes in C‐reactive protein to inhibit pro‐inflammatory actions	79
HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy	76
Depressive patient‐derived GABA interneurons reveal abnormal neural activity associated with HTR2C	76
Targetable Brg1‐CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking	74
A preclinical model of peripheral T‐cell lymphoma GATA3 reveals DNA damage response pathway vulnerability	73
TFEB and TFE3 drive kidney cystogenesis and tumorigenesis	64
IQCN disruption causes fertilization failure and male infertility due to manchette assembly defect	61
Glomerular endothelial cell senescence drives age‐related kidney disease through PAI‐1	61
Activation of the integrated stress response is a vulnerability for multidrug‐resistant FBXW7 ‐deficient cells	56
Metformin rescues migratory deficits of cells derived from patients with periventricular heterotopia	55
When fat meets the gut—focus on intestinal lipid handling in metabolic health and disease	55
Eosinophil‐derived IL ‐4 is necessary to establish the inflammatory structure in innate inflammation	53
Identification of treatment‐induced vulnerabilities in pancreatic cancer patients using functional model systems	53
Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain	53
ASO targeting RBM3 temperature‐controlled poison exon splicing prevents neurodegeneration in vivo	52
Diagnostic biomarkers for active tuberculosis: progress and challenges	51
Systemic inflammation after stroke: implications for post‐stroke comorbidities	51
Shear stress control of vascular leaks and atheromas through Tie2 activation by VE‐PTP sequestration	50
Nerve regeneration by interferon intervention in aging brain	49

Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy	49
Spleen tyrosine kinase mediates innate and adaptive immune crosstalk in SARS‐CoV‐2 mRNA vaccination	48
Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model	48
Functions of double‐negative B cells in autoimmune diseases, infections, and cancers	47
Single‐cell profiling of muscle‐infiltrating T cells in idiopathic inflammatory myopathies	44
Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer	44
Looking at a baby's heart through the lens of the mother's blood	42
Macrophage colony‐stimulating factor as a weapon against cytomegalovirus	42
ALX1 ‐related frontonasal dysplasia results from defective neural crest cell development and migration	42
TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT	40
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy	40
An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV ‐2	40
A type IV Autotaxin inhibitor ameliorates acute liver injury and nonalcoholic steatohepatitis	40
Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease	40
Mining the bacterial genome to discover new antimicrobial molecules	39
Optimizing the Cas13 antiviral train: cargo and delivery	39
Blocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T‐cell lymphoma	39
In vitro and in vivo drug screens of tumor cells identify novel therapies for high‐risk child cancer	39
In vivo single‐cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection	39
Sex differences and risk factors for bleeding in Alagille syndrome	37
Advances in high‐throughput mass spectrometry in drug discovery	37
The molecular biology of peritoneal metastatic disease	37
A novel platform for attenuating immune hyperactivity using EXO‐CD24 in COVID‐19 and beyond	37
Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis	36
The human host response to monkeypox infection: a proteomic case series study	36
Elucidating effects of environmental exposure using human‐induced pluripotent stem cell disease modeling	36
Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation	36
Immuno(T)herapy for age‐related diseases	36
X‐linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL	36
AAV induces hepatic necroptosis and carcinoma in diabetic and obese mice dependent on Pebp1 pathway	36
Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis	35
IL‐27 produced during acute malaria infection regulates Plasmodium‐specific memory CD4+ T cells	35
Nanobody‐mediated complement activation to kill HIV‐infected cells	34
External validity in translational biomedicine: understanding the conditions enabling the cause to have an effect	34
Systemic gene therapy rescues retinal dysfunction and hearing loss in a model of Norrie disease	34
Adaptively evolved human oral actinomyces‐sourced defensins show therapeutic potential	33
miR ‐181a/b downregulation: a mutation‐independent therapeutic approach for inherited retinal diseases	33
Trichothiodystrophy‐associated MPLKIP maintains DBR1 levels for proper lariat debranching and ectodermal differentiation	33
Liver gene therapy with intein‐mediated F8 trans ‐splicing corrects mouse haemophilia A	32
Molecular and functional properties of human Plasmodium falciparum CSP C‐terminus antibodies	32
Nuclear PRMT5 is a biomarker of sensitivity to tamoxifen in ERα+ breast cancer	32
Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in SARS‐CoV‐2 mouse models of infection	31
Answer to Gerber et al. “Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy”	31
NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5	30
TAPT1—at the crossroads of extracellular matrix and signaling in Osteogenesis imperfecta	30
Dual IRE1 RNase functions dictate glioblastoma development	30
Full eradication of pre‐clinical human papilloma virus‐induced tumors by a lentiviral vaccine	30
Development of allogeneic iPS cell‐based therapy: from bench to bedside	30
Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcoma	29
AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model	29

A clinically compatible drug‐screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis	29
Patient‐ and xenograft‐derived organoids recapitulate pediatric brain tumor features and patient treatments	29
A progeroid syndrome caused by a deep intronic variant in TAPT1 is revealed by RNA/SI‐NET sequencing	29
AAV‐delivered diacylglycerol kinase DGKk achieves long‐term rescue of fragile X syndrome mouse model	28
Uncovering a conserved vulnerability site in SARS‐CoV‐2 by a human antibody	28
BET1 variants establish impaired vesicular transport as a cause for muscular dystrophy with epilepsy	27
Transfixed by transgenics: how pathology assumptions are slowing progress in Alzheimer's disease and related dementia research	27
SPINK6 inhibits human airway serine proteases and restricts influenza virus activation	26
Long non‐coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling	26
RNAi to treat SARS‐CoV‐2—variant proofing the next generation of therapies	26
MSTO1 is a cytoplasmic pro‐mitochondrial fusion protein, whose mutation induces myopathy and ataxia in humans	26
Lack of the human choline transporter‐like protein SLC44A2 causes hearing impairment and a rare red blood phenotype	26
Disrupting metformin adaptation of liver cancer cells by targeting the TOMM34/ATP5B axis	25
Targeting the liver to treat the eye	25
The Sec61 translocon is a therapeutic vulnerability in multiple myeloma	24
A whole‐genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors	24
COVID‐19 vaccination, time for a second breath?	23
Intestinal Apc‐inactivation induces HSP25 dependency	23
Epigenetic silencing of SALL2 confers tamoxifen resistance in breast cancer	23
mAb therapy controls CNS‐resident lyssavirus infection via a CD4 T cell‐dependent mechanism	23
DGAT inhibition at the post‐absorptive phase reduces plasma FA by increasing FA oxidation	23
Molecular mechanisms for the modulation of blood pressure and potassium homeostasis by the distal convoluted tubule	23
Therapeutic activation of endothelial sphingosine‐1‐phosphate receptor 1 by chaperone‐bound S1P suppresses proliferative retinal neovascularization	23
Repurposing immunosuppressants for antileukemia therapy	23
Seasonality of influenza and other respiratory viruses	22
β‐Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T‐cell acute lymphoblastic leukemia	22
Alteration of microbiota antibody‐mediated immune selection contributes to dysbiosis in inflammatory bowel diseases	22
Antagonizing microRNA ‐19a/b augments PTH anabolic action and restores bone mass in osteoporosis in mice	22
Clinical grade ACE2 as a universal agent to block SARS‐CoV ‐2 variants	22
Blockade of the pro‐fibrotic reaction mediated by the miR‐143/‐145 cluster enhances the responses to targeted therapy in melanoma	22
Interactions between BRD4S, LOXL2, and MED1 drive cell cycle transcription in triple‐negative breast cancer	22
Anti‐tumoural activity of the G‐quadruplex ligand pyridostatin against BRCA1/2‐deficient tumours	22
Liver‐directed gene therapy for ornithine aminotransferase deficiency	21
Adoptive T cell therapy cures mice from active hemophagocytic lymphohistiocytosis (HLH)	21
A catalog of numerical centrosome defects in epithelial ovarian cancers	21
Early 5‐HT 6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse	21
Propionate reinforces epithelial identity and reduces aggressiveness of lung carcinoma	21
IMPDH inhibition activates TLR‐VCAM1 pathway and suppresses the development of MLL‐fusion leukemia	21
Long non‐coding RNA MALAT1 regulates retinal neurodegeneration through CREB signaling	21
A nontyphoidal Salmonella serovar domestication accompanying enhanced niche adaptation	21
iPSC‐based modeling of THD recapitulates disease phenotypes and reveals neuronal malformation	20
A high‐resolution 3D atlas of the spectrum of tuberculous and COVID ‐19 lung lesions	20
Maternal diet and gut microbiome composition modulate early‐life immune development	20
Interferon regulates neural stem cell function at all ages by orchestrating mTOR and cell cycle	20
Cingulin regulates hair cell cuticular plate morphology and is required for hearing in human and mouse	20
Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ‐secretase activity	20
Immunotherapy targeting isoDGR‐protein damage extends lifespan in a mouse model of protein deamidation	19
Sensitivity towards HDAC inhibition is associated with RTK / MAPK pathway activation in gastric	19
Enhancement of efferocytosis through biased FPR2 signaling attenuates intestinal inflammation	19
Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons	19
Oxidative stress enhances the therapeutic action of a respiratory inhibitor in MYC‐driven lymphoma	19
Can THEM6 targeting stop resistance to prostate cancer treatment?	19
Tumor‐associated macrophages‐educated reparative macrophages promote diabetic wound healing	19
Microbiota dysbiosis influences immune system and muscle pathophysiology of dystrophin‐deficient mice	18
Allelic effects on uromodulin aggregates drive autosomal dominant tubulointerstitial kidney disease	18
Mutated axon guidance gene PLXNB2 sustains growth and invasiveness of stem cells isolated from cancers of unknown primary	18
Dual IRE1 RNase functions dictate glioblastoma development	18
Emerging roles of ATG7 in human health and disease	18
Artificial sweeteners inhibit multidrug‐resistant pathogen growth and potentiate antibiotic activity	18
Single‐cell transcriptomics reveals a senescence‐associated IL ‐6/ CCR6 axis driving radiodermatitis	18
Targeting CRAC channels in inflammatory bowel disease	18
Paired box 6 gene delivery preserves beta cells and improves islet transplantation efficacy	18
Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability	18
Propylene glycol inactivates respiratory viruses and prevents airborne transmission	17
Graft conditioning with fluticasone propionate reduces graft‐versus‐host disease upon allogeneic hematopoietic cell transplantation in mice	17
Caspase‐8 in endothelial cells maintains gut homeostasis and prevents small bowel inflammation in mice	17
Intratumoral co‐injection of NK cells and NKG2A‐neutralizing monoclonal antibodies	17
Genetically modified macrophages accelerate myelin repair	16
Neuropilin‐1 ( NRP1 ) expression distinguishes self‐reactive helper T cells in systemic autoimmune disease	16
Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy	16
S1P defects cause a new entity of cataract, alopecia, oral mucosal disorder, and psoriasis‐like syndrome	16
LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease	16
Acquired immunity against SARS‐CoV‐2 infection and vaccination	16
Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia	16
When dysbiosis meets dystrophy: an unwanted gut‐muscle connection	16
Microbial metabolites in chronic heart failure and its common comorbidities	16
Inhibition of O‐GlcNAcylation protects from Shiga toxin‐mediated cell injury and lethality in host	16
Feed‐forward loops between metastatic cancer cells and their microenvironment—the stage of escalation	15
In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues	15
Comparison of tumor‐informed and tumor‐naïve sequencing assays for ctDNA detection in breast cancer	15

Live imaging of neolymphangiogenesis identifies acute antimetastatic roles of dsRNA mimics	15
FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder	15
The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity	15
Lifting the iron curtain of vision	15
Aged lipid‐laden microglia display impaired responses to stroke	15