OOIR: Observatory of International Research

Papers

(The TQCC of EMBO Molecular Medicine is 26. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-05-01 to 2025-05-01.)

Article	Citations
Whole‐brain microscopy reveals distinct temporal and spatial efficacy of anti‐Aβ therapies	327
THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer	212
miR‐9 modulates and predicts the response to radiotherapy and EGFR inhibition in HNSCC	144
uPA‐PAI‐1 heteromerization promotes breast cancer progression by attracting tumorigenic neutrophils	133
Autologous, lentivirus‐modified, T‐rapa cell “micropharmacies” for lysosomal storage disorders	130
Circulating proteomic panels for risk stratification of intracranial aneurysm and its rupture	125
Targeting the Leukemic stem cell protein machinery by inhibition of mitochondrial pyrimidine synthesis	123
Targeting conformational changes in C‐reactive protein to inhibit pro‐inflammatory actions	115
Elongator and the role of its subcomplexes in human diseases	109
When fat meets the gut—focus on intestinal lipid handling in metabolic health and disease	100
Flower lose, a cell fitness marker, predicts COVID‐19 prognosis	87
Activation of the integrated stress response is a vulnerability for multidrug‐resistant FBXW7 ‐deficient cells	84
HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy	81
The state of the art of bispecific antibodies for treating human malignancies	68
Depressive patient‐derived GABA interneurons reveal abnormal neural activity associated with HTR2C	65
TFEB and TFE3 drive kidney cystogenesis and tumorigenesis	64
Targetable Brg1‐CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking	63
A preclinical model of peripheral T‐cell lymphoma GATA3 reveals DNA damage response pathway vulnerability	61
IQCN disruption causes fertilization failure and male infertility due to manchette assembly defect	60
Glomerular endothelial cell senescence drives age‐related kidney disease through PAI‐1	55
Metformin rescues migratory deficits of cells derived from patients with periventricular heterotopia	54
Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain	54
Bi‐allelic VPS16 variants limit HOPS/CORVET levels and cause a mucopolysaccharidosis‐like disease	54
Identification of treatment‐induced vulnerabilities in pancreatic cancer patients using functional model systems	53
Eosinophil‐derived IL ‐4 is necessary to establish the inflammatory structure in innate inflammation	53

Tau PET correlates with different Alzheimer’s disease‐related features compared to CSF and plasma p‐tau biomarkers	53
ASO targeting RBM3 temperature‐controlled poison exon splicing prevents neurodegeneration in vivo	51
Systemic inflammation after stroke: implications for post‐stroke comorbidities	50
Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy	48
Diagnostic biomarkers for active tuberculosis: progress and challenges	48
Nerve regeneration by interferon intervention in aging brain	48
Spleen tyrosine kinase mediates innate and adaptive immune crosstalk in SARS‐CoV‐2 mRNA vaccination	47
Single‐cell profiling of muscle‐infiltrating T cells in idiopathic inflammatory myopathies	47
Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer	46
Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation	46
Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model	45
Functions of double‐negative B cells in autoimmune diseases, infections, and cancers	44
Shear stress control of vascular leaks and atheromas through Tie2 activation by VE‐PTP sequestration	44
Pharmacological or genetic inhibition of iNOS prevents cachexia‐mediated muscle wasting and its associated metabolism defects	43
Identification of TAPBPL as a novel negative regulator of T‐cell function	43
Optimizing the Cas13 antiviral train: cargo and delivery	42
Looking at a baby's heart through the lens of the mother's blood	41
A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy	40
Macrophage colony‐stimulating factor as a weapon against cytomegalovirus	40
ALX1 ‐related frontonasal dysplasia results from defective neural crest cell development and migration	40
A type IV Autotaxin inhibitor ameliorates acute liver injury and nonalcoholic steatohepatitis	39
Mining the bacterial genome to discover new antimicrobial molecules	39
TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT	38
In vitro and in vivo drug screens of tumor cells identify novel therapies for high‐risk child cancer	38
An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV ‐2	38
In vivo single‐cell transcriptomics reveal Klebsiella pneumoniae skews lung macrophages to promote infection	37
Blocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T‐cell lymphoma	37
Advances in high‐throughput mass spectrometry in drug discovery	37
Protein Kinase D2 drives chylomicron‐mediated lipid transport in the intestine and promotes obesity	36
Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component	36
Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease	35
Elucidating effects of environmental exposure using human‐induced pluripotent stem cell disease modeling	35
Sex differences and risk factors for bleeding in Alagille syndrome	35
AAV induces hepatic necroptosis and carcinoma in diabetic and obese mice dependent on Pebp1 pathway	34
X‐linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL	34
Deconstructing progressive inflammatory fibrosis in recessive dystrophic epidermolysis bullosa	34
miR‐33 in cardiometabolic diseases: lessons learned from novel animal models and approaches	34
Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis	33
The human host response to monkeypox infection: a proteomic case series study	33
A novel platform for attenuating immune hyperactivity using EXO‐CD24 in COVID‐19 and beyond	33
Immuno(T)herapy for age‐related diseases	33
Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis	32
The molecular biology of peritoneal metastatic disease	32
LAG3 is not expressed in human and murine neurons and does not modulate α‐synucleinopathies	32
Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation	32
External validity in translational biomedicine: understanding the conditions enabling the cause to have an effect	32
Soluble P‐tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau	32
Nanobody‐mediated complement activation to kill HIV‐infected cells	31
miR ‐181a/b downregulation: a mutation‐independent therapeutic approach for inherited retinal diseases	31
Trichothiodystrophy‐associated MPLKIP maintains DBR1 levels for proper lariat debranching and ectodermal differentiation	31

IL‐27 produced during acute malaria infection regulates Plasmodium‐specific memory CD4⁺ T cells	31
CXCR4 engagement triggers CD47 internalization and antitumor immunization in a mouse model of mesothelioma	31
Systemic gene therapy rescues retinal dysfunction and hearing loss in a model of Norrie disease	30
Alleviation of a polyglucosan storage disorder by enhancement of autophagic glycogen catabolism	30
Rational design of West Nile virus vaccine through large replacement of 3′ UTR with internal poly(A)	29
Full eradication of pre‐clinical human papilloma virus‐induced tumors by a lentiviral vaccine	29
Adaptively evolved human oral actinomyces‐sourced defensins show therapeutic potential	29
YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis	29
Liver gene therapy with intein‐mediated F8 trans ‐splicing corrects mouse haemophilia A	29
Answer to Gerber et al. “Autosomal recessive pathogenic MSTO1 variants in hereditary optic atrophy”	28
Dual IRE1 RNase functions dictate glioblastoma development	28
A progeroid syndrome caused by a deep intronic variant in TAPT1 is revealed by RNA/SI‐NET sequencing	28
Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in SARS‐CoV‐2 mouse models of infection	28
Nuclear PRMT5 is a biomarker of sensitivity to tamoxifen in ERα⁺ breast cancer	28
Patient‐ and xenograft‐derived organoids recapitulate pediatric brain tumor features and patient treatments	27
A spoonful of L‐fucose—an efficient therapy for GFUS‐CDG, a new glycosylation disorder	27
Molecular and functional properties of human Plasmodium falciparum CSP C‐terminus antibodies	27
A clinically compatible drug‐screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis	27
TAPT1—at the crossroads of extracellular matrix and signaling in Osteogenesis imperfecta	27
AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model	27
NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5	27
Gene therapy in the putamen for curing AADC deficiency and Parkinson's disease	26
microRNAs trip down memory lane	26
AAV‐delivered diacylglycerol kinase DGKk achieves long‐term rescue of fragile X syndrome mouse model	26
Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcoma	26
Transfixed by transgenics: how pathology assumptions are slowing progress in Alzheimer's disease and related dementia research	26
Development of allogeneic iPS cell‐based therapy: from bench to bedside	26
RNAi to treat SARS‐CoV‐2—variant proofing the next generation of therapies	26