OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Cardiology is 13. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Bariatric metabolic surgery more effective than GLP1R agonists in preventing congestive HF	705
Aggregation of big tau disrupts microtubules and causes diastolic dysfunction	514
Antibody treatment to deplete transthyretin amyloid deposits in the heart	434
Sacubitril–valsartan shows benefit in heart failure with ejection fraction of >40%	359
LIPC variant in combined hypocholesterolaemia	321
Intravascular imaging improves outcomes	303
Injectable and conductive cardiac patch	283
Travelling with heart failure: risk assessment and practical recommendations	275
Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: a global perspective	268
Neuroimmune axis of cardiovascular control: mechanisms and therapeutic implications	267
Screening for Helicobacter pylori infection in patients with cardiovascular and gastrointestinal disease	255
Accelerated reduction in global cardiovascular disease is essential to achieve the Sustainable Development Goals	250
Changing epidemiology of congenital heart disease: effect on outcomes and quality of care in adults	247
Genetics and mechanisms of thoracic aortic disease	238
Abbreviating DAPT reduces the risk of bleeding	230
Alternative defibrillation strategies improve outcomes	217
Think Aorta: aortic dissection awareness and perspectives from the patient	212
Electron microscopy of cardiac 3D nanodynamics: form, function, future	210
Factor XI inhibitors in patients with cardiovascular disease and a high risk of bleeding: a cautionary tale	204
Defining iron deficiency in patients with heart failure	202
Detection of subclinical hypertrophic cardiomyopathy	199
European guidelines for hypertension in 2024: a comparison of key recommendations for clinical practice	196
Contemporary coronary artery bypass graft surgery and subsequent percutaneous revascularization	189
Maternal cardiovascular disorders before and during pregnancy and offspring cardiovascular risk across the life course	181
Hallmarks of cardiovascular ageing	168

Neuromodulation reduces inflammation in HFpEF	162
A fatty acid from mother’s milk drives cardiomyocyte maturation in newborn mice	162
Extracellular matrix in vascular homeostasis and disease	160
Graded exercise therapy should not be recommended for patients with post-exertional malaise	158
Decongestion in heart failure: medical and device therapies	156
Preparticipation screening reduces SCD in young athletes	153
Increased degradation of desmosomal proteins in ACM	148
CSDE1 regulates LDL receptor levels	141
Catheter ablation improves outcomes in patients with AF and end-stage HF	140
No benefit of apoA-I infusion after myocardial infarction	139
Colchicine in acute coronary syndromes: the present and the possible future	138
Identifying leukocyte phenotypes by scRNA-seq to predict cardiovascular risk	138
LDL-cholesterol lowering with obicetrapib	122
Targeting immune cell recruitment in atherosclerosis	121
Tailored therapeutics for cardiomyopathies	116
Reactive oxygen species in hypertension	115
Genomic enhancers in cardiac development and disease	114
Prevention of atherosclerosis from childhood	109
The oral microbiome in the pathophysiology of cardiovascular disease	107
Treatment of mild chronic hypertension in pregnancy reduces pre-eclampsia risk	106
RNA interference lowers triglyceride levels	105
Modelling pre-eclampsia and its cardiovascular effects	104
Not a spectator sport: improving participation of Black patients in cardiovascular clinical trials	98
Reply to ‘Graded exercise therapy should not be recommended for patients with post-exertional malaise’	97
Donor macrophages influence rejection of transplanted hearts	97
Cardiac sarcomere turnover by unidirectional replacement of proteins	92
Bempedoic acid prevents cardiovascular events in statin-intolerant patients	92
Promising novel siRNA for the treatment of hypertension	88
Unlocking excellence in health care: the power of inclusive and sensitive language in medicine	88
Semaglutide is beneficial in patients with HFpEF and obesity	88
BP management with a village-doctor-led strategy	82
Global epidemiology of heart failure	82
Evidence does not support the reduction of added sugar intake from all food sources	82
Single-cell profiles of CHD and CM	81
An epigenome editing approach induces durable silencing of Pcsk9	80
CV benefits of finerenone in T2DM and CKD	76
Author Correction: The contribution of amyloid deposition in the aortic valve to calcification and aortic stenosis	76
Computational modelling of cardiovascular pathophysiology to risk stratify commercial spaceflight	76
Simvastatin protects against endothelial dysfunction via epigenetic mechanisms	75
Clonal haematopoiesis in cardiovascular disease: prognostic role and novel therapeutic target	72
Novel factor XIa inhibitor reduces bleeding compared with apixaban in atrial fibrillation	72
The role of the molecular autopsy in sudden cardiac death in young individuals	71
Development of a miniature, bioresorbable, light-activated pacemaker	70
Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology	70
Heart transplantation: advances in expanding the donor pool and xenotransplantation	69
Efferocytosis in atherosclerosis	68
Low alcohol intake might lower CVD risk by reducing stress-related brain activity	66
CNR1 antagonism attenuates cannabis-induced atherosclerosis	66
Gut bacteria can break down cholesterol	66
New insights into dietary cholesterol absorption	66

Molecular gatekeepers of endogenous adult mammalian cardiomyocyte proliferation	65
Fibroblast-like cells promote plaque stability in response to anti-IL-1β therapy	65
Cardiovascular benefits of fermented foods and beverages: still up for debate	64
Transcatheter aortic valve implantation in patients with bicuspid valve morphology: a roadmap towards standardization	62
Renal denervation for hypertension	62
Improving medication adherence in cardiovascular disease	60
Mechanisms and treatment of pulmonary arterial hypertension	59
Cardiovascular disease and cancer: shared risk factors and mechanisms	56
Phenotyping atherosclerotic plaque and perivascular adipose tissue: signalling pathways and clinical biomarkers in atherosclerosis	56
Targeting ALK1 to block LDL transcytosis and halt atherosclerosis	55
Pacing with respiratory sinus arrhythmia improves outcomes in heart failure	54
Publisher Correction: Cardiac involvement in the long-term implications of COVID-19	53
Inclusion of remnant cholesterol improves risk prediction for ischaemic heart disease	52
Cardiac optogenetics: controlling the heart with light	51
Epigenetic editing in cardiovascular medicine: moving beyond the hype	50
RNA-based therapies targeting APOC3 lower triglyceride levels in patients with hypertriglyceridaemia	50
Heart failure and obesity: novel insights leading to new treatment paradigms	49
The need for increased pragmatism in cardiovascular clinical trials	48
Metabolic remodelling in atrial fibrillation: manifestations, mechanisms and clinical implications	48
A fresh look at coronary microembolization	47
Restoration of flow in the aorta: a novel therapeutic target in aortic valve intervention	47
Blood pressure and its variability: classic and novel measurement techniques	46
Regression of cardiac hypertrophy in health and disease: mechanisms and therapeutic potential	44
The cardiac parasympathetic system has two parallel circuits	44
Age-induced senescence impairs the neurovascular interface in the heart	43
Boosting mitochondrial metabolism with dietary supplements in heart failure	43
Inhibiting aldosterone synthase reduces blood pressure	43
Combined measure of inflammation, cholesterol and lipoprotein(a) predicts 30-year cardiovascular risk in women	43
Black In Cardio: promoting diversity and representation in the cardiovascular field	41
Sotatercept as add-on therapy for advanced PAH	37
Gout flares can precede cardiovascular events	37
Tracing the roots of cardiac fibrosis: role of endothelial-to-mesenchymal transition	34
Trials and tribulations of cell therapy for heart failure: an update on ongoing trials	33
ASGR1 inhibition stimulates cholesterol excretion	33
Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications	32
Phase separation of protein kinase A: a new paradigm in cardiac regulation?	31
The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases	29
Consequences of ionizing radiation exposure to the cardiovascular system	29
Cardiovascular autonomic dysfunction in post-COVID-19 syndrome: a major health-care burden	29
Surgery safer than endovascular therapy for CLTI	28
Roadmap on the use of artificial intelligence for imaging of vulnerable atherosclerotic plaque in coronary arteries	28
A distinct platelet differentiation pathway is involved in age-related thrombocytosis	27
Preserving the future of heart transplantation	26
Benefit of early aortic valve surgery in asymptomatic, severe AS	26
Characterization of the F8 gene: a silver lining in a dark cloud	26
Publisher Correction: Non-canonical features of microRNAs: paradigms emerging from cardiovascular disease	26
Imaging cAMP nanodomains in human iPSC-derived cardiomyocytes	26
Effects of lifestyle factors on leukocytes in cardiovascular health and disease	25
Leadless and extravascular cardiac resynchronization therapy: the future for CRT?	25
Genome editing prevents hypertrophic cardiomyopathy in mice	25
High troponin I levels predict death after surgery	24
A role for lipophagy in atherosclerosis	24
Glucagon-like peptide 1 receptor agonists: cardiovascular benefits and mechanisms of action	24
Metabolism of triglyceride-rich lipoproteins in health and dyslipidaemia	24
Posterior left pericardiotomy reduces AF incidence after cardiac surgery	23
Unravelling the genetic heart–brain connection using MRI	23
Alain Cribier (1945–2024)	22
Sustained BP reduction with renal denervation	20
Heartbeat-induced pressure pulsations in cerebral arteries modulate neuronal activity	20
Repurposing drugs to treat cardiovascular disease in the era of precision medicine	19
Cardiac splicing as a diagnostic and therapeutic target	19
Charting the future of cardiology with large language model artificial intelligence	18
Mind the gap: sex-related differences in cardiovascular disease	17
Implementing LGBTQ-inclusive policies for cardiology practice and the workforce	17
Mapping the functions of IgM antibodies in atherosclerotic cardiovascular disease	17
Extracellular vesicles in cardiovascular homeostasis and disease: potential role in diagnosis and therapy	17
The dynamic cardiac cellular landscape: visualization by molecular imaging	16
Contemporary pharmacological treatment and management of heart failure	16
Pathophysiology of dilated cardiomyopathy: from mechanisms to precision medicine	16
Wearable blood pressure sensors for cardiovascular monitoring and machine learning algorithms for blood pressure estimation	14
Coronary CT angiography evaluation with artificial intelligence for individualized medical treatment of atherosclerosis: a Consensus Statement from the QCI Study Group	13
Current concepts and novel targets for antiplatelet therapy	13
The ongoing quest for the first total artificial heart as destination therapy	13
Epidemiology and prevention of venous thromboembolism	13
Single-cell transcriptomics for the assessment of cardiac disease	13