OOIR: Observatory of International Research

Papers

(The TQCC of Nature Reviews Endocrinology is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Exposing skin to ultraviolet irradiation increases food intake in male individuals	657
Non-nutritive sweeteners — too sweet to be wholesome?	599
Dexamethasone in patients with diabetes mellitus	562
Exercise-induced plasma factors confer brain benefits	542
CNOT6L regulates hepatokine expression	383
The role of DNA damage in diabetic complications	351
Immune cell population prevents weight regain	343
Memory of obesity stored in adipocytes	336
Identification of genetic factors of type 2 diabetes mellitus risk in South Asian populations	332
Author Correction: Adrenocortical stem cells in health and disease	286
The challenges of assessing adiposity in a clinical setting	236
Limiting the use and misuse of liothyronine in hypothyroidism	231
Thyroid function and iodine intake: global recommendations and relevant dietary trends	195
Timed high-fat diet feeding restores small bowel circadian rhythms	177
Effects of diet on atherosclerotic plaque development	177
Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead	167
The gut microbiota in obesity and weight management: microbes as friends or foe?	158
Metformin reduces ageing adipose senescence	148
Negative regulator of GDF15 signalling identified	146
Ketosis improves muscle stem cell resilience	141
Obesity phenotypes: explaining the unexplained	140
Metabolite levels during the menstrual cycle	137
A pivotal year for NAFLD and NASH therapeutics	136
Amylin: emergent therapeutic opportunities in overweight, obesity and diabetes mellitus	135
Reply to ‘Ensuring diverse representation and minimizing conflicts of interest in clinical practice guidelines’	130

The evolving functions of the vasculature in regulating adipose tissue biology in health and obesity	127
Research in metabolic ageing — a tale of mice versus humans?	126
Neurons in the diagonal band of Broca moderate food intake	122
Patients’ insights into diabetes insipidus	117
Role for exosomes in insulin sensitivity	117
Handle with care — interpretation, synthesis and dissemination of data on paracetamol in pregnancy	112
mTORC1 is the central regulator in pancreatic β-cells	107
The interactions between energy homeostasis and neurovascular plasticity	106
Ensuring diverse representation and minimizing conflicts of interest in clinical practice guidelines	101
Steroid hormones as modulators of anti-tumoural immunity	101
Primary aldosteronism — a multidimensional syndrome	97
GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease	96
One hundred years of insulin therapy	96
A role for phosphocreatine in adipose inflammation	95
Genetic risk scores improve prediction of obesity in survivors of childhood cancer	94
Ketogenic modification of the liver proteome	94
New role for bone marrow adipocytes in obesity	93
Stem-cell derived pancreatic endoderm cells in the treatment of T1DM	87
Role of extracellular vesicles in β-cell failure	87
Progress in islet transplantation is more important than ever	86
The metabolic mythos of ketones	85
Targeting the incretin system in obesity and type 2 diabetes mellitus	80
Bone and muscle crosstalk in ageing and disease	79
A role for the kidney in metformin action	78
Urocortin 3 function in glucose metabolism	78
RalA links obesity and mitochondrial dysfunction	76
GLP1–oestrogen agonist protects β-cells from insulin-deficient diabetes mellitus	74
Advances in basic biology and translation in islet research	73
Inflammation-induced adrenal dysfunction	72
Advances in incretin-based therapeutics for obesity	71
Endosomal trafficking in metabolic homeostasis and diseases	70
Luteal phase support in assisted reproductive technology	64
Signals from the dorsal motor nucleus of the vagus promote jejunal fat absorption	61
Triggering puberty in primates: is it NPY?	60
Untangling the pathways of SDHx loss of function	60
Leptin–thyroid hormone axis affects energy use in muscle	59
The metabolic benefits of exercise-induced hepatic autophagy	59
The role of ultra-processed food in obesity	57
A multi-omics roadmap of β-cell failure in type 2 diabetes mellitus	57
REG3G — a potential link between the intestinal microbiome and host physiology	56
Tracing the biological roots of obesity resistance in humans	53
Iatrogenic adrenal insufficiency in adults	50
New insights into β-cell failure, regeneration and replacement	50
Islet hormones at the intersection of glucose and amino acid metabolism	50
A global view of hypertensive disorders and diabetes mellitus during pregnancy	49
Skeletal and extraskeletal disorders of biomineralization	48
Length of light exposure alters energy metabolism in mice	48
Potential downsides of calorie restriction	48
HIF1α inhibition preserves β-cell function	48
Remission of T2DM requires early diagnosis and substantial weight reduction	46

Potential role for follicular Treg cells in T1DM	46
From the perspective of a scientist with Cushing disease, what did not kill me made my science stronger	46
Melatonin prevents diabetes mellitus-induced bone loss	46
Sex hormones in SARS-CoV-2 susceptibility: key players or confounders?	46
Obesity dysregulates a pituitary–liver axis through disruption of the unfolded protein response	46
Unravelling umami-induced obesity	44
GLP1 receptor agonist overcomes SGLT2 inhibitor-related overeating	43
Why does the immune system destroy pancreatic β-cells but not α-cells in type 1 diabetes?	43
Vitamin D supplementation and fracture risk	42
Investigating the effects of artificial sweeteners	42
Cardiorenal diseases in type 2 diabetes mellitus: clinical trials and real-world practice	40
Lipid droplet biogenesis and functions in health and disease	39
Sarcopenic obesity in older adults: a clinical overview	38
Continuous glucose monitoring for the routine care of type 2 diabetes mellitus	38
Engineered Tregs prevent diabetes mellitus in mice	37
GnRH pulses affect ageing in male mice	36
At the 2022 Congress on Obesity	36
Variation in serotonin 2C receptor linked with obesity and behaviour	35
Energy intake at the intersection of the clock and ageing	31
Mitigating the environmental effects of healthcare: the role of the endocrinologist	31
The glymphatic system as a nexus between obesity and neurological diseases	31
Large study on hormone therapy for transgender youth provides reassurance amid treatment politicization	30
Metformin and GDF15: where are we now?	30
Adaptive immune cells shape obesity-associated type 2 diabetes mellitus and less prominent comorbidities	30
Sertoli cell lysosomal dysfunction drives age-related testicular degeneration	30
Molecular transducers and the cardiometabolic benefits of exercise	30
Growth hormone-releasing hormone and its analogues in health and disease	29
Exercise in adults with type 1 diabetes mellitus	28
Targeting senescent cells in ageing-related endocrine diseases	27
Epigenetics of type 2 diabetes mellitus and weight change — a tool for precision medicine?	27
Arginine vasopressin deficiency: diagnosis, management and the relevance of oxytocin deficiency	27
Exosomes as novel biomarkers in metabolic disease and obesity-related cancers	26
A mitochondrial trigger for beige adipocyte development	26
New genes associated with adult-onset obesity	26
Mitochondria transported from adipocytes in extracellular vesicles	25
Interventions in people newly diagnosed with type 1 diabetes mellitus	25
TIM4+ adipose tissue-resident macrophages: new modulators of adiposity	24
Highlights from SfE BES 2021	24
Paracetamol use in pregnancy — caution over causal inference from available data	22
Nutrient regulation of bone marrow adipose tissue: skeletal implications of weight loss	21
Individualized and innovative gender healthcare for transgender and nonbinary youth	21
GWAS gives insights into glucose regulation	20
Can obesity pharmacotherapy be used to manage male infertility?	20
International consensus guidelines on the implementation and monitoring of vosoritide therapy in individuals with achondroplasia	20
Advancing precision nutrition: bridging mechanistic insight and clinical implementation	20
Medically not yet explained symptoms in hypothyroidism	19
The regulation of endocrine-disrupting chemicals to minimize their impact on health	19
Combination therapy increases human β-cell mass in vivo	18
SRC2 controls the refeeding response in mice	18
Sex differences in diabetic kidney disease explained	18
Variation in metformin pharmacokinetics	18
Brown adipose tissue fights the battle against leukaemia	18
Masterful papers that broke open understanding of reproductive neuroendocrinology	17
Metabolic effects of gender-affirming hormone therapy	17
Monogenic diabetes mellitus hidden in autoantibody-negative diabetes mellitus	17
Author Correction: Consensus Statement on the definition and classification of metabolic hyperferritinaemia	17
Knowledge in youth is wisdom in age: involving young people in research	17
Environmental factors in declining human fertility	16
Glial control of neuronal function	16
The complex effects of dietary restriction on longevity and health	16
Highlights from ADA 85th Scientific Sessions	16
The study that pioneered islet isolation techniques	15
An updated view on human neonatal thermogenesis	15
Antioxidant liver myeloid cell population identified	15
Dysfunctional lipid metabolism in ageing muscle: effects on glucose tolerance	15
AcroBATics: how dying brown adipocytes trigger browning	15
FGF1 signalling cascade suppresses lipolysis	15
A role for HDAC6 in leptin sensitivity	15
Author Correction: Seeing through the fog: a neuroendocrine explanation for post-COVID cognitive deficits	15
Senescent immune cells promote skeletal ageing	15
Highlights from ADA 82nd Scientific Sessions	15
Bone fragility in type 2 diabetes mellitus: a lot left to explore	14
Obesity induces epigenetic memory in innate immune cells	14
Paracetamol use in pregnancy — neglecting context promotes misinterpretation	14
Skeletal stem and progenitor cells in bone physiology, ageing and disease	13
New variant for monogenic obesity	12
Genomics suggest role for IGF1 resistance in T2DM	12
CAMK1D required for ghrelin-mediated food intake	12
Understanding the complexity of insulin resistance	12