OOIR: Observatory of International Research

Papers

(The TQCC of Molecular Medicine Reports is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Obesity ‑ a risk factor for increased COVID‑19 prevalence, severity and lethality (Review)	255
Dexmedetomidine alleviated sepsis‑induced myocardial ferroptosis and septic heart injury	131
Protective role of taurine against oxidative stress (Review)	86
Diabetic‑induced alterations in hepatic glucose and lipid metabolism: The role of type 1 and type 2 diabetes mellitus (Review)	66
Cartilage tissue engineering: From proinflammatory and anti‑inflammatory cytokines to osteoarthritis treatments (Review)	61
Acute spinal cord injury: Pathophysiology and pharmacological intervention (Review)	61
HIF‑1α in myocardial ischemia‑reperfusion injury (Review)	60
Neuropilin‑1 as a new potential SARS‑CoV‑2 infection mediator implicated in the neurologic features and central nervous system involvement of COVID‑19	54
Monotropein alleviates H2O2‑induced inflammation, oxidative stress and apoptosis via NF‑κB/AP‑1 signaling	46
Elevated plasma levels of exosomal BACE1‑AS combined with the volume and thickness of the right entorhinal cortex may serve as a biomarker for the detection of Alzheimer's disease	44
Significance of taurine transporter (TauT) in homeostasis and its layers of regulation (Review)	42
Effects and molecular mechanism of pachymic acid on ferroptosis in renal ischemia reperfusion injury	42
circRNA‑0006896‑miR1264‑DNMT1 axis plays an important role in carotid plaque destabilization by regulating the behavior of endothelial cells in atherosclerosis	41
Long non-coding RNA ANRIL knockdown suppresses apoptosis and pro-inflammatory cytokines while enhancing neurite outgrowth via binding microRNA-125a in a cellular model of Alzheimer's disease	39
Exosomes from miR-29a-modified adipose-derived mesenchymal stem cells reduce excessive scar formation by inhibiting TGF-β2/Smad3 signaling	38
LINC00861 inhibits the progression of cervical cancer cells by functioning as a ceRNA for miR‑513b‑5p and regulating the PTEN/AKT/mTOR signaling pathway	37
M2‑like tumour‑associated macrophage‑secreted IGF promotes thyroid cancer stemness and metastasis by activating the PI3K/AKT/mTOR pathway	36
[Comment] The COVID‑19 pandemic as a scientific and social challenge in the 21st century	35
Telomerase and telomeres in aging theory and chronographic aging theory (Review)	35
Metformin induces apoptosis and inhibits migration by activating the AMPK/p53 axis and suppressing PI3K/AKT signaling in human cervical cancer cells	34
lncRNA TPTEP1 inhibits stemness and radioresistance of glioma through miR‑106a‑5p‑mediated P38 MAPK signaling	34
Piceatannol protects against cerebral ischemia/reperfusion‑induced apoptosis and oxidative stress via the Sirt1/FoxO1 signaling pathway	33
Sarcopenia, frailty and type 2 diabetes mellitus (Review)	33
COVID‑19 vaccination and IgG and IgA antibody dynamics in healthcare workers	31
Role of hypoxia inducible factor-1 in cancer stem cells (Review)	31

BMP2 induces hMSC osteogenesis and matrix remodeling	31
lncRNA MALAT1 modulates cancer stem cell properties of liver cancer cells by regulating YAP1 expression via miR‑375 sponging	31
Apigenin induces apoptosis by regulating Akt and MAPK pathways in human melanoma cell A375SM	30
Advanced glycation end products promote osteoporosis by inducing ferroptosis in osteoblasts	30
Application of nanotechnology in drug delivery systems for respiratory diseases (Review)	30
Molecular mechanisms of cancer cachexia‑induced muscle atrophy (Review)	30
Asiaticoside produces an antidepressant‑like effect in a chronic unpredictable mild stress model of depression in mice, involving reversion of inflammation and the PKA/pCREB/BDNF signaling pathway	30
lncRNA PVT1 modulates NLRP3‑mediated pyroptosis in septic acute kidney injury by targeting miR‑20a‑5p	29
Curcumin attenuates lncRNA H19‑induced epithelial‑mesenchymal transition in tamoxifen‑resistant breast cancer cells	29
Molecular insights into the benefits of nicotine on memory and cognition (Review)	28
Capsaicin suppresses breast cancer cell viability by regulating the CDK8/PI3K/Akt/Wnt/β‑catenin signaling pathway	28
Multi‑faceted role of cancer‑associated adipocytes in the tumor microenvironment (Review)	28
Ginsenoside Re exhibits neuroprotective effects by inhibiting neuroinflammation via CAMK/MAPK/NF‑κB signaling in microglia	27
Knockdown of exosome‑mediated lnc‑PVT1 alleviates lipopolysaccharide‑induced osteoarthritis progression by mediating the HMGB1/TLR4/NF‑κB pathway via miR‑93‑5p	27
Exogenous hydrogen sulfide reduces atrial remodeling and atrial fibrillation induced by diabetes mellitus via activation of the PI3K/Akt/eNOS pathway	27
Tumor‑associated macrophages in lung cancer: Friendly or evil? (Review)	26
Hsa‑circRNA‑G004213 promotes cisplatin sensitivity by regulating miR‑513b‑5p/PRPF39 in liver cancer	26
Salusin‑β participates in high glucose‑induced HK‑2 cell ferroptosis in a Nrf‑2‑dependent manner	26
Allisartan isoproxil attenuates oxidative stress and inflammation through the SIRT1/Nrf2/NF‑κB signalling pathway in diabetic cardiomyopathy rats	26
Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy	25
Naringin ameliorates memory deficits and exerts neuroprotective effects in a mouse model of Alzheimer's disease by regulating multiple metabolic pathways	25
Ginsenoside Rg1 improves cognitive capability and affects the microbiota of large intestine of tree shrew model for Alzheimer's disease	25
Punicalagin inhibited proliferation, invasion and angiogenesis of osteosarcoma through suppression of NF‑κB signaling	24
Roseburia�intestinalis‑derived flagellin ameliorates colitis by targeting miR‑223‑3p‑mediated activation of NLRP3 inflammasome and pyroptosis	24
Eupafolin alleviates cerebral ischemia/reperfusion injury in rats via blocking the TLR4/NF‑κB signaling pathway	24
Relationship between the pyroptosis of fibroblast‑like synoviocytes and HMGB1 secretion in knee osteoarthritis	24
Hydrogen sulfide ameliorates doxorubicin‑induced myocardial fibrosis in rats via the PI3K/AKT/mTOR pathway	24
Τelomerase inhibitors and activators in aging and cancer: A systematic review	24
Gold nanoparticle‑mediated delivery of paclitaxel and nucleic acids for cancer therapy (Review)	23
Serum long non‑coding RNA NNT‑AS1 protected by exosome is a potential biomarker and functions as an oncogene via the miR‑496/RAP2C axis in colorectal cancer	23
circ-PRKCI targets miR-1294 and miR-186-5p by downregulating FOXK1 expression to suppress glycolysis in hepatocellular carcinoma	23
Interplay of retinol binding protein 4 with obesity and associated chronic alterations (Review)	23
lncRNA‑MALAT1 promotes high glucose‑induced H9C2 cardiomyocyte pyroptosis by downregulating miR‑141‑3p expression	23
Laminin‑332 mediates proliferation, apoptosis, invasion, migration and epithelial‑to‑mesenchymal transition in pancreatic ductal adenocarcinoma	23
Exosomal circular RNA_400068 promotes the development of renal cell carcinoma via the miR‑210‑5p/SOCS1 axis	22
Functions of circular RNAs in bladder, prostate and renal cell cancer (Review)	22
Ginsenoside Rk1 protects human melanocytes from H₂O₂‑induced oxidative injury via regulation of the PI3K/AKT/Nrf2/HO‑1 pathway	22
Cellular senescence: A pathogenic mechanism of pelvic organ prolapse (Review)	22
Expression levels of the α7 nicotinic acetylcholine receptor in the brains of patients with Alzheimer's disease and their effect on synaptic proteins in SH-SY5Y cells	22
MicroRNA‑494 suppresses hypoxia/reoxygenation‑induced cardiomyocyte apoptosis and autophagy via the PI3K/AKT/mTOR signaling pathway by targeting SIRT1	22
Downregulation of lncRNA ZFAS1 protects H9c2 cardiomyocytes from ischemia/reperfusion‑induced apoptosis via the miR‑590‑3p/NF‑κB signaling pathway	22
Long non‑coding RNA MEG3 inhibits cell migration and invasion of non‑small cell lung cancer cells by regulating the miR‑21‑5p/PTEN axis	22
Wnt/β‑catenin signaling: Causes and treatment targets of drug resistance in colorectal cancer (Review)	22
Saikosaponin D inhibits autophagosome‑lysosome fusion and induces autophagy‑independent apoptosis in MDA‑MB‑231 breast cancer cells	22
Ameliorative effects and mechanism of crocetin in arsenic trioxide‑induced cardiotoxicity in rats	21
Cytotoxic effect of CLL‑1 CAR‑T cell immunotherapy with PD‑1 silencing on relapsed/refractory acute myeloid leukemia	21
miR‑27a‑3p negatively regulates osteogenic differentiation of MC3T3‑E1 preosteoblasts by targeting osterix	21
Upregulation of microRNA‑1 inhibits proliferation and metastasis of breast cancer	21
circSAMD4A participates in the apoptosis and autophagy of dopaminergic neurons via the miR‑29c‑3p‑mediated AMPK/mTOR pathway in Parkinson's disease	21
Curcumin ameliorates DSS‑induced colitis in mice by regulating the Treg/Th17 signaling pathway	21

Ginsenoside Rg1 ameliorates aging‑induced liver fibrosis by inhibiting the NOX4/NLRP3 inflammasome in SAMP8 mice	21
miR‑214 ameliorates sepsis‑induced acute kidney injury via PTEN/AKT/mTOR‑regulated autophagy	21
MicroRNA‑199a‑5p suppresses cell proliferation, migration and invasion by targeting ITGA3 in colorectal cancer	21
Primary open angle glaucoma genetics: The common variants and their clinical associations (Review)	21
Salvianolic acid B alleviates myocardial ischemic injury by promoting mitophagy and inhibiting activation of the NLRP3 inflammasome	21
Metformin protects high glucose‑cultured cardiomyocytes from oxidative stress by promoting NDUFA13 expression and mitochondrial biogenesis via the AMPK signaling pathway	20
miR‑192‑5p upregulation mediates the suppression of curcumin in human NSCLC cell proliferation, migration and invasion by targeting c‑Myc and inactivating the Wnt/β‑catenin signaling pathway	20
Crosstalk between NK cells and hepatic stellate cells in liver fibrosis (Review)	20
LncRNA GAS5 suppresses ER stress‑induced apoptosis and inflammation by regulating SERCA2b in HG‑treated retinal epithelial cell	20
Age affects the paracrine activity and differentiation potential of human adipose‑derived stem cells	20
Reoxygenation induces reactive oxygen species production and ferroptosis in renal tubular epithelial cells by activating aryl hydrocarbon receptor	20
Astaxanthin induces NADPH oxidase activation and receptor‑interacting protein kinase 1‑mediated necroptosis in gastric cancer AGS cells	20
Benchmarking of next and third generation sequencing technologies and their associated algorithms for de novo genome assembly	20
Tripterygium glycoside suppresses epithelial‑to‑mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway	20
Downregulation of microRNA‑106a‑5p alleviates ox‑LDL‑mediated endothelial cell injury by targeting STAT3	20
Roles of α‑synuclein in gastrointestinal microbiome dysbiosis‑related Parkinson's disease progression (Review)	19
All‑trans retinoic acid promotes macrophage phagocytosis and decreases inflammation via inhibiting CD14/TLR4 in acute lung injury	19
Biological and neurological activities of astaxanthin (Review)	19
GAS5 regulates diabetic cardiomyopathy via miR‑221‑3p/p27 axis‑associated autophagy	19
Inhibitory role of ginsenoside Rb2 in endothelial senescence and inflammation mediated by microRNA‑216a	19
Development and characterization of TrMab‑6, a novel anti‑TROP2 monoclonal antibody for antigen detection in breast cancer	19
Ginsenoside Rh2 stimulates the production of mitochondrial reactive oxygen species and induces apoptosis of cervical cancer cells by inhibiting mitochondrial electron transfer chain complex	19
S100A8 and S100A9 promote endothelial cell activation through the RAGE‑mediated mammalian target of rapamycin complex 2 pathway	19
Coenzyme Q10 alleviates sevoflurane‑induced neuroinflammation by regulating the levels of apolipoprotein E and phosphorylated tau protein in mouse hippocampal neurons	19
FABP4 knockdown suppresses inflammation, apoptosis and extracellular matrix degradation in IL-1β-induced chondrocytes by activating PPARγ to regulate the NF-κB signaling pathway	19
Advances in the application of molecular diagnostic techniques for the detection of infectious disease pathogens (Review)	19
Current treatment strategies for COVID‑19 (Review)	19
Identification of potential markers for type 2 diabetes mellitus via bioinformatics analysis	19
Ferroptosis inhibitor ferrostatin‑1 alleviates homocysteine‑induced ovarian granulosa cell injury by regulating TET activity and DNA methylation	19
Mmu_circ_003795 regulates osteoblast differentiation and mineralization in MC3T3‑E1 and MDPC23 by targeting COL15A1	19
Clinical characteristics and prognostic significance of TCGA and ACRG classification in gastric cancer among the Chinese population	18
Shikonin inhibits the Warburg effect, cell proliferation, invasion and migration by downregulating PFKFB2 expression in lung cancer	18
Effects of Sirt3‑autophagy and resveratrol activation on myocardial hypertrophy and energy metabolism	18
miR‑124‑3p regulates angiogenesis in peripheral arterial disease by targeting STAT3	18
Tanshinone IIA attenuates heart failure via inhibiting oxidative stress in myocardial infarction rats	18
Role of DRAM1 in mitophagy contributes to preeclampsia regulation in mice	18
Germacrone induces lung cancer cell apoptosis and cell cycle arrest via the Akt/MDM2/p53 signaling pathway	18
LY‑294002 enhances the chemosensitivity of liver cancer to oxaliplatin by blocking the PI3K/AKT/HIF‑1α pathway	18
Apatinib suppresses the migration, invasion and angiogenesis of hepatocellular carcinoma cells by blocking VEGF and PI3K/AKT signaling pathways	18
Anticancer effect of caudatin in diethylnitrosamine‑induced hepatocarcinogenesis in rats	18
Butorphanol protects PC12 cells against OGD/R-induced inflammation and apoptosis	18
Hesperidin ameliorates liver ischemia/reperfusion injury via activation of the Akt pathway	18
IL‑33/ST2 promotes the malignant progression of gastric cancer via the MAPK pathway	18
Radiation‑induced dysfunction of energy metabolism in the heart results in the fibrosis of cardiac tissues	18
SIRT6‑specific inhibitor OSS‑128167 exacerbates diabetic cardiomyopathy by aggravating inflammation and oxidative stress	17
Fine particulate matter induces airway inflammation by disturbing the balance between Th1/Th2 and regulation of GATA3 and Runx3 expression in BALB/c mice	17
S100A16 suppresses the proliferation, migration and invasion of colorectal cancer cells in part via the JNK/p38 MAPK pathway	17
Hydrogen sulfide attenuates renal I/R‑induced activation of the inflammatory response and apoptosis via regulating Nrf2‑mediated NLRP3 signaling pathway inhibition	17
The potential role and trend of HIF‑1α in intervertebral disc degeneration: Friend or foe? (Review)	17
Long non‑coding RNA NNT‑AS1 knockdown represses the progression of gastric cancer via modulating the miR‑142‑5p/SOX4/Wnt/β‑catenin signaling pathway	17
Procyanidin B2 inhibits lipopolysaccharide‑induced apoptosis by suppressing the Bcl‑2/Bax and NF‑κB signalling pathways in human umbilical vein endothelial cells	17
Dimethyl itaconate inhibits LPS‑induced microglia inflammation and inflammasome‑mediated pyroptosis via inducing autophagy and regulating the Nrf‑2/HO‑1 signaling pathway	17
Resveratrol affects the expression of uric acid transporter by improving inflammation	17
Claudin 6: Therapeutic prospects for tumours, and mechanisms of expression and regulation (Review)	17
Polygonatum sibiricum F. Delaroche polysaccharide ameliorates HFD‑induced mouse obesity via regulation of lipid metabolism and inflammatory response	17
Salvianolic acid B attenuates renal interstitial fibrosis by regulating the HPSE/SDC1 axis	17
miR‑143‑3p inhibits endometriotic stromal cell proliferation and invasion by inactivating autophagy in endometriosis	17
Hypoxia‑induced lactate dehydrogenase A protects cells from apoptosis in endometriosis	17
Possibility of exosome‑based coronavirus disease 2019 vaccine (Review)	17
Long non‑coding RNA growth arrest‑specific 5 (GAS5) acts as a tumor suppressor by promoting autophagy in breast cancer	17
Lidocaine attenuates hypoxia/reoxygenation‑induced inflammation, apoptosis and ferroptosis in lung epithelial cells by regulating the p38 MAPK pathway	17
Transcriptional activation of ENPP2 by FoxO4 protects cardiomyocytes from doxorubicin‑induced toxicity	17
Mechanisms underlying the protective effect of tannic acid against arsenic trioxide‑induced cardiotoxicity in rats: Potential involvement of mitochondrial apoptosis	17
Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy	17
Erastin‑induced ferroptosis causes physiological and pathological changes in healthy tissues of mice	17
miR‑101‑3p negatively regulates inflammation in systemic lupus erythematosus via MAPK1 targeting and inhibition of the NF‑κB pathway	16
Exploration of the hepatoprotective effect and mechanism of magnesium isoglycyrrhizinate in mice with arsenic trioxide‑induced acute liver injury	16
Ferroptosis in hepatic ischemia‑reperfusion injury: Regulatory mechanisms and new methods for therapy (Review)	16
Anti‑chondrocyte apoptosis effect of genistein in treating inflammation‑induced osteoarthritis	16
CBX2 depletion inhibits the proliferation, invasion and migration of gastric cancer cells by inactivating the YAP/β-catenin pathway	16
Different roles of matrix metalloproteinase 2 in osteolysis of skeletal dysplasia and bone metastasis (Review)	16
Tanshinone IIA regulates microRNA‑125b/foxp3/caspase‑1 signaling and inhibits cell viability of nasopharyngeal carcinoma	16
Immature granulocytes: Innovative biomarker for SARS‑CoV‑2 infection	16
Identification of potential crucial genes and molecular mechanisms in glioblastoma multiforme by bioinformatics analysis	16
κ‑opioid receptor agonist, U50488H, inhibits pyroptosis through NLRP3 via the Ca²⁺/CaMKII/CREB signaling pathway and improves synaptic plasticity in APP/PS1 mice	16
Circulating microRNA‑135a‑3p in serum extracellular vesicles as a potential biological marker of non‑alcoholic fatty liver disease	16
Mangiferin inhibits cell migration and angiogenesis via PI3K/AKT/mTOR signaling in high glucose‑ and hypoxia‑induced RRCECs	16
Total flavonoids of Rhizoma drynariae ameliorate steroid‑induced avascular necrosis of the femoral head via the PI3K/AKT pathway	16
Sphingosine kinase 1 contributes to doxorubicin resistance and glycolysis in osteosarcoma	16
Melatonin inhibits proliferation and viability and promotes apoptosis in colorectal cancer cells via upregulation of the microRNA-34a/449a cluster	16

lncRNA SNHG4 promotes cell proliferation, migration, invasion and the epithelial-mesenchymal transition process via sponging miR-204-5p in gastric cancer	16
Dexmedetomidine alleviates early brain injury following traumatic brain injury by inhibiting autophagy and neuroinflammation through the ROS/Nrf2 signaling pathway	16
Knockdown of circ‑PVT1 inhibits the progression of lung adenocarcinoma and enhances the sensitivity to cisplatin via the miR‑429/FOXK1 signaling axis	16
miR‑576‑5p promotes epithelial‑to‑mesenchymal transition in colorectal cancer by targeting the Wnt5a‑mediated Wnt/β‑catenin signaling pathway	16
Low expression of miR‑532‑3p contributes to cerebral ischemia/reperfusion oxidative stress injury by directly targeting NOX2	16
NLRP3 inflammasome in sepsis (Review)	16
lncRNA GAS5 promotes pyroptosis in COPD by functioning as a ceRNA to regulate the miR‑223‑3p/NLRP3 axis	16
Propofol‑induced miR‑125a‑5p inhibits the proliferation and metastasis of ovarian cancer by suppressing LIN28B	16
Buyang Huanwu Decoction promotes neurogenesis via sirtuin 1/autophagy pathway in a cerebral ischemia model	16
Expression profile and diagnostic value of circRNAs in peripheral blood from patients with systemic lupus erythematosus	16
Role of indoleamine 2,3-dioxygenase in ischemia-reperfusion injury of renal tubular epithelial cells	16
MicroRNA‑223‑induced inhibition of the FBXW7 gene affects the proliferation and apoptosis of colorectal cancer cells via the Notch and Akt/mTOR pathways	16
linc‑ROR facilitates hepatocellular carcinoma resistance to doxorubicin by regulating TWIST1‑mediated epithelial‑mesenchymal transition	16
miR‑199a‑3p suppresses cervical epithelial cell inflammation by inhibiting the HMGB1/TLR4/NF‑κB pathway in preterm birth	16
Resveratrol induces human colorectal cancer cell apoptosis by activating the mitochondrial pathway via increasing reactive oxygen species	16
miR‑142‑5p inhibits pancreatic cancer cell migration and invasion by targeting PIK3CA	16
Novel insights into di‑(2‑ethylhexyl)phthalate activation: Implications for the hypothalamus‑pituitary‑thyroid axis	15
Identification of prognostic biomarkers and drug target prediction for colon cancer according to a competitive endogenous RNA network	15
lncRNA MIR4435‑2HG promotes the progression of liver cancer by upregulating B3GNT5 expression	15
Inhibition of chaperone‑mediated autophagy reduces tumor growth and metastasis and promotes drug sensitivity in colorectal cancer	15
Dendrobium mixture attenuates renal damage in rats with diabetic nephropathy by inhibiting the PI3K/Akt/mTOR pathway	15
Systemic inflammatory response syndrome is triggered by mitochondrial damage (Review)	15
Lycium barbarum polysaccharide protects ARPE‑19 cells against H₂O₂‑induced oxidative stress via the Nrf2/HO‑1 pathway	15
Major signaling pathways and key mediators of macrophages in acute kidney injury (Review)	15
Knockdown of miR‑205‑5p alleviates the inflammatory response in allergic rhinitis by targeting B‑cell lymphoma 6	15
CART mitigates oxidative stress and DNA damage in memory deficits of APP/PS1 mice via upregulating β‑amyloid metabolism‑associated enzymes	15
Circulating extracellular vesicles from patients with breast cancer enhance migration and invasion via a Src‑dependent pathway in MDA‑MB‑231 breast cancer cells	15
Sacubitril/valsartan (LCZ696) reduces myocardial injury following myocardial infarction by inhibiting NLRP3‑induced pyroptosis via the TAK1/JNK signaling pathway	15
Effects of miR‑195‑5p on cell proliferation and apoptosis in gestational diabetes mellitus via targeting EZH2	15
Mental depression: Relation to different disease status, newer treatments and its association with COVID-19 pandemic (Review)	15
SEC61G is upregulated and required for tumor progression in human kidney cancer	15
miR‑126 overexpression attenuates oxygen‑glucose deprivation/reperfusion injury by inhibiting oxidative stress and inflammatory response via the activation of SIRT1/Nrf2 signaling pathway in human umb	15
B7‑H3 promotes the epithelial‑mesenchymal transition of NSCLC by targeting SIRT1 through the PI3K/AKT pathway	15
lncRNA NEAT1 regulates gastric carcinoma cell proliferation, invasion and apoptosis via the miR‑500a‑3p/XBP‑1 axis	15
PPARγ attenuates hepatic inflammation and oxidative stress of non‑alcoholic steatohepatitis via modulating the miR‑21‑5p/SFRP5 pathway	15
ABT‑737, a Bcl‑2 family inhibitor, has a synergistic effect with apoptosis by inducing urothelial carcinoma cell necroptosis	15
Radioprotective countermeasures for radiation injury (Review)	15
Combined administration of SHP2 inhibitor SHP099 and the α7nAChR agonist PNU282987 protect mice against DSS‑induced colitis	15
A combination of PD‑1/PD‑L1 inhibitors: The prospect of overcoming the weakness of tumor immunotherapy (Review)	15
Shikonin inhibits CEBPD downregulation in IL‑17‑treated HaCaT cells and in an imiquimod‑induced psoriasis model	15
Long non‑coding RNA JPX promotes gastric cancer progression by regulating CXCR6 and autophagy via inhibiting miR‑197	15
Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice	15
Identification and validation of EPHX2 as a prognostic biomarker in hepatocellular carcinoma	15
Upregulation of CCT3 promotes cervical cancer progression through FN1	15
lncRNA VIM‑AS1 promotes cell proliferation, metastasis and epithelial‑mesenchymal transition by activating the Wnt/β‑catenin pathway in gastric cancer	15
HIF‑1α in cerebral ischemia (Review)	15
lncRNA FGD5 antisense RNA 1 upregulates RORA to suppress hypoxic injury of human cardiomyocyte cells by inhibiting oxidative stress and apoptosis via miR‑195	14
Oral peroxidases: From antimicrobial agents to ecological actors (Review)	14
Ulinastatin protects against sepsis‑induced myocardial injury by inhibiting NLRP3 inflammasome activation	14
MicroRNA‑21‑5p protects melanocytes via targeting STAT3 and modulating Treg/Teff balance to alleviate vitiligo	14
Toosendanin induces apoptosis of MKN‑45 human gastric cancer cells partly through miR‑23a‑3p‑mediated downregulation of BCL2	14
Downregulated miR‑29a promotes B cell overactivation by upregulating Crk‑like protein in systemic lupus erythematosus	14
miR‑139‑5p enhances cisplatin sensitivity in non‑small cell lung cancer cells by inhibiting cell proliferation and promoting apoptosis via the targeting of Homeobox protein Hox‑B2	14
Association between HO‑1 gene promoter polymorphisms and diseases (Review)	14
Nicotinamide mononucleotide attenuates glucocorticoid‑induced osteogenic inhibition by regulating the SIRT1/PGC‑1α signaling pathway	14
Acute glucose fluctuation promotes RAGE expression via reactive oxygen species‑mediated NF‑κB activation in rat podocytes	14
PDGF mediates pulmonary arterial smooth muscle cell proliferation and migration by regulating NFATc2	14
Lycium barbarum polysaccharide protects rats and cardiomyocytes against ischemia/reperfusion injury via Nrf2 activation through autophagy inhibition	14
In vitro anti‑bacterial activity of diosgenin on Porphyromonas gingivalis and Prevotella intermedia	14
Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis	14
Anti‑inflammatory compounds moracin O and P from Morus alba Linn. (Sohakuhi) target the NF‑κB pathway	14
Atezolizumab alleviates the immunosuppression induced by PD‑L1‑positive neutrophils and improves the survival of mice during sepsis	14
miR‑379‑5p inhibits cell proliferation and promotes cell apoptosis in non‑small cell lung cancer by targeting β‑arrestin‑1	14
Statin rosuvastatin inhibits apoptosis of human coronary artery endothelial cells through upregulation of the JAK2/STAT3 signaling pathway	14
Regulation of angiogenesis by microRNAs in cancer	14
DUSP6 protects murine podocytes from high glucose‑induced inflammation and apoptosis	14
Essential oil ofFoeniculum vulgaresubsp.piperitumfruits exerts an anti‑tumor effect in triple‑negative breast cancer cells	14
lncRNA CASC2 inhibits lipopolysaccharide‑induced acute lung injury via miR‑27b/TAB2 axis	14
Wild‑type IDH1 affects cell migration by modulating the PI3K/AKT/mTOR pathway in primary glioblastoma cells	14
lncRNA TUG1 inhibits the cancer stem cell‑like properties of temozolomide‑resistant glioma cells by interacting with EZH2	14
Aspirin attenuates liver fibrosis by suppressing TGF‑β1/Smad signaling	14
Troxerutin attenuates oxygen‑glucose deprivation and reoxygenation‑induced oxidative stress and inflammation by enhancing the PI3K/AKT/HIF‑1α signaling pathway in H9C2 cardiomyocytes	14
MAPK inhibitors protect against early‑stage osteoarthritis by activating autophagy	14
Targeting protein palmitoylation decreases palmitate‑induced sphere formation of human liver cancer cells	14
miR‑10a‑5p inhibits osteogenic differentiation of bone marrow‑derived mesenchymal stem cells	14
Saccharomyces boulardii modulates necrotizing enterocolitis in neonatal mice by regulating the sirtuin 1/NF‑κB pathway and the intestinal microbiota	14
Association of the DNASE1L3 rs35677470 polymorphism with systemic lupus erythematosus, rheumatoid arthritis and systemic sclerosis: Structural biological insights	14
Liraglutide protects palmitate-induced INS-1 cell injury by enhancing autophagy mediated via FoxO1	14
Sufentanil attenuates inflammation and oxidative stress in sepsis-induced acute lung injury by downregulating KNG1 expression	14
Resveratrol alleviates oxygen/glucose deprivation/reoxygenation‑induced neuronal damage through induction of mitophagy	14
Connective tissue growth factor promotes retinal pigment epithelium mesenchymal transition via the PI3K/AKT signaling pathway	14
Role of the SIRT1/p53 regulatory axis in oxidative stress‑mediated granulosa cell apoptosis	14
Integrated analysis of miRNA and mRNA expression in the blood of patients with Alzheimer's disease	14
MicroRNA‑592 promotes cell proliferation, migration and invasion in colorectal cancer by directly targeting SPARC	14
Inhibition of p38 MAPK regulates epileptic severity by decreasing expression levels of A1R and ENT1	13
Overexpression of hsa_circ_0001445 reverses oxLDL‑induced inhibition of HUVEC proliferation via SRSF1	13
Phillygenin inhibits the inflammation and apoptosis of pulmonary epithelial cells by activating PPARγ signaling via downregulation of MMP8	13
Overexpression of ATG4a promotes autophagy and proliferation, and inhibits apoptosis in lens epithelial cells via the AMPK and Akt pathways	13
Overexpression of lncRNA Dancr inhibits apoptosis and enhances autophagy to protect cardiomyocytes from endoplasmic reticulum stress injury via sponging microRNA-6324	13
miR‑18a‑5p promotes melanoma cell proliferation and inhibits apoptosis and autophagy by targeting EPHA7 signaling	13
Ferrostatin‑1 alleviates oxalate‑induced renal tubular epithelial cell injury, fibrosis and calcium oxalate stone formation by inhibiting ferroptosis	13
Sirt3 promotes the autophagy of HK‑2 human proximal tubular epithelial cells via the inhibition of Notch‑1/Hes‑1 signaling	13
Anti‑inflammatory mechanism of berberine on lipopolysaccharide‑induced IEC‑18 models based on comparative transcriptomics	13
NDRG2 attenuates ischemia-induced astrocyte necroptosis via the repression of RIPK1	13
Nerve growth factor regulates liver cancer cell polarity and motility	13