OOIR: Observatory of International Research

Papers

(The H4-Index of Theranostics is 84. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Young Bone Marrow Sca-1 Cells Rejuvenate the Aged Heart by Promoting Epithelial-to-Mesenchymal Transition: Erratum	736
Bispecific antibodies targeting EGFR/Notch enhance the response to talazoparib by decreasing tumour-initiating cell frequency	563
A transcriptional biosensor to monitor single cancer cell therapeutic responses by bioluminescence microscopy	479
Biosynthetic gas vesicles as a novel ultrasound contrast agent for diagnosing and treating myocardial infarction	429
A low molecular weight multifunctional theranostic molecule for the treatment of prostate cancer	270
3D autofluorescence imaging of hydronephrosis and renal anatomical structure using cryo-micro-optical sectioning tomography	266
Bisecting GlcNAc modification reverses the chemoresistance via attenuating the function of P-gp	254
ASIC1a Induces Excessive Mitophagy and PANoptosis of Chondrocyte by the Inhibition of SIRT3 Mitochondrial Translocation	248
Comprehensive omics analyses profile genesets related with tumor heterogeneity of multifocal glioblastomas and reveal LIF/CCL2 as biomarkers for mesenchymal subtype	221
AI-powered 3D pathology protocol enhances enteric nervous system visualization and quantification for clinical diagnostics	218
Noninvasive closed-loop acoustic brain-computer interface for seizure control	198
Recent progress of nano-drugs in neutron capture therapy	193
Focused ultrasound-enhanced nose-to-brain delivery of a therapeutic antibody in a large-animal model	192
Transcriptome analysis reveals EBF1 ablation-induced injuries in cardiac system	191
Nrf2 and HIF1α converge to arsenic-induced metabolic reprogramming and the formation of the cancer stem-like cells: Erratum	191
Self-boosting targeted anticancer therapy via cancer cell self-reprogramming with GGT-targeting oxidative stress nanoamplifiers	189
“Electron transport chain interference” strategy of amplified bacterial ferroptosis and defect-engineered nanozyme for diabetic wound healing	181
Targeting cancer with precision: strategical insights into TCR-engineered T cell therapies	168
Theranostics application of tumor-initiating cell probe TiY in non-small cell lung cancer	166
The LMIT: Light-mediated minimally-invasive theranostics in oncology	165
Dual-targeted magnetic mesoporous silica nanoparticles reduce brain amyloid-β burden via depolymerization and intestinal metabolism	165
Tumor-derived EV miRNA signatures surpass total EV miRNA in supplementing mammography for precision breast cancer diagnosis	164
High-fidelity imaging of amyloid-beta deposits with an ultrasensitive fluorescent probe facilitates the early diagnosis and treatment of Alzheimer's Disease	161
Discovery of novel antibacterial agent for the infected wound treatment: all-hydrocarbon stapling optimization of LL-37	159
Proteomes from AMPK-inhibited peripheral blood mononuclear cells suppress the progression of breast cancer and bone metastasis	157

ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold	156
Glucosylceramide regulates depression through activating peroxisome proliferator-activated receptor gamma in dorsal striatum	154
Targeted delivery of anti-miRNA21 sensitizes PD-L1^high tumor to immunotherapy by promoting immunogenic cell death	151
5-Aminolevulinate improves metabolic recovery and cell survival of the liver following cold preservation	150
Cell-membrane-coated nanoparticles for the fight against pathogenic bacteria, toxins, and inflammatory cytokines associated with sepsis	147
A FRET-based off-on AIE nanoprobe enables instant and stain-free detection of hypoxic niches in tumor sections	138
RNF138 regulates skeletal muscle differentiation via the Wnt/β-catenin signaling pathway	136
GPAT3 is a potential therapeutic target to overcome sorafenib resistance in hepatocellular carcinoma	136
Dopamine receptor 1 on CaMKII-positive neurons within claustrum mediates adolescent cocaine exposure-induced anxiety-like behaviors and electro-acupuncture therapy	132
Betaine inhibits the stem cell-like properties of hepatocellular carcinoma by activating autophagy via SAM/m⁶A/YTHDF1-mediated enhancement on ATG3 stability	132
Highly potent and selective PPARδ agonist reverses memory deficits in mouse models of Alzheimer's disease	132
Surface-engineered extracellular vesicles for targeted delivery of therapeutic RNAs and peptides for cancer therapy	127
A bifunctional fusion membrane-based biocompatible nanovaccine to potentiate cancer immunotherapy	127
Current advances in temozolomide encapsulation for the enhancement of glioblastoma treatment	125
A p-n heterojunction sonosensitizer for improved sono-immunotherapy via induction of multimodal cell death mechanisms	121
In vivo outer hair cell gene editing ameliorates progressive hearing loss in dominant-negative Kcnq4 murine model	120
Ferritin light chain promotes the reprogramming of glioma immune microenvironment and facilitates glioma progression	117
Towards effective CAIX-targeted radionuclide and checkpoint inhibition combination therapy for advanced clear cell renal cell carcinoma	117
Emerging microfluidics-enabled platforms for osteoarthritis management: from benchtop to bedside	117
FUNDC1 alleviates doxorubicin-induced cardiotoxicity by restoring mitochondrial-endoplasmic reticulum contacts and blocked autophagic flux	115
Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms	111
Molecular Imaging-Derived Biomarker of Cardiac Nerve Integrity — Introducing High NET Affinity PET Probe ¹⁸F-AF78	110
Peptide receptor radionuclide therapy (PRRT) in metastatic neuroendocrine tumors of unknown primary (CUP-NETs)	110
The emerging role of Piezo1 in the musculoskeletal system and disease	109
SPOP downregulation promotes bladder cancer progression based on cancer cell-macrophage crosstalk via STAT3/CCL2/IL-6 axis and is regulated by VEZF1	109
Human pluripotent stem cell-derived ectomesenchymal stromal cells promote more robust functional recovery than umbilical cord-derived mesenchymal stromal cells after hypoxic-ischaemic brain damage	108
Stimulation by exosomes from hypoxia-preconditioned hair follicle mesenchymal stem cells facilitates mitophagy by inhibiting the PI3K/AKT/mTOR signaling pathway to alleviate ulcerative colitis	108
FGFR blockade boosts T cell infiltration into triple-negative breast cancer by regulating cancer-associated fibroblasts	106
Perfluorocarbon-polyepinephrine core-shell nanoparticles as a near-infrared light activatable theranostic platform for bimodal imaging-guided photothermal/chemodynamic synergistic cancer therapy	105
Multifunctional metal-organic framework (MOF)-based nanoplatforms for cancer therapy: from single to combination therapy	105
A multifunctional injectable microsphere with enhanced near-infrared photo-antibacterial, ROS scavenging, and anti-inflammatory properties for periodontitis treatment	105
Minimally invasive implantation and decreased inflammation reduce osteoinduction of biomaterial: Erratum	104
A Transferrin-Conjugated Hollow Nanoplatform for Redox-Controlled and Targeted Chemotherapy of Tumor with Reduced Inflammatory Reactions: Erratum	103
Optic chiasmatic potential by endoscopically implanted skull base microinvasive biosensor: a brain-machine interface approach for anterior visual pathway assessment	99
Programmatically activated DNA hydrogel microcapsules for precision therapy in inflammatory bowel disease	99
Cell-free secretome of CD56 ^bright CD16 ^bright directly reprogrammed NK cells enhances wound heali	98
The first abdominal aortic aneurysm organoid model replicates complex microenvironment for in vitro disease study	98
Comprehensive machine learning-generated classifier identifies pro-metastatic characteristics and predicts individual treatment in pancreatic cancer: A multicenter cohort study based on super-enhancer	97
Pathologically responsive ZnSrMo-LDH/Cu nanozymes with cascade antioxidant and angiogenic functions for myocardial ischemia-reperfusion treatment	96
Antibody-induced internalization and degradation of PLA2R amplifies CD4⁺ T cell activation	96
Development of a nanoparticle-based immunotherapy targeting CD137 for nasopharyngeal carcinoma treatment	95
The combination of calreticulin-targeting L-ASNase and anti-PD-L1 antibody modulates the tumor immune microenvironment to synergistically enhance the antitumor efficacy of radiotherapy	94
Extracellular vesicles: catching the light of intercellular communication in fibrotic liver diseases	93
Topical application of TAK1 inhibitor encapsulated by gelatin particle alleviates corneal neovascularization	92
NAD⁺-boosting molecules suppress mast cell degranulation and anaphylactic responses in mice	92
Supercharging CAR-T cells through transcriptional and epigenetic armoring	92
Twist1 downregulation of PGC-1α decreases fatty acid oxidation in tubular epithelial cells, leading to kidney fibrosis: Erratum	91
First-in-human study of an optimized, potential kit-type, SSTR antagonist ⁶⁸Ga-DATA^5m-LM4 in patients with metastatic neuroendocrine tumors	91
FGF19 in Solid Tumors: Molecular Mechanisms, Metabolic Reprogramming, and Emerging Therapeutic Opportunities	91
Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging: Erratum	89

KMV-mediated cardiomyocyte-to-endothelial cell signaling drives capillary rarefaction to promote heart failure following pressure overload	89
Targeting formyl peptide receptor 2 to suppress neuroinflammation in neuromyelitis optica spectrum disorder	89
Weak acid-initiated slow release of Dexamethasone from hydrogel to treat orbital inflammation	88
Developing an efficient MGCR microneedle nanovaccine patch for eliciting Th 1 cellular response against the SARS-CoV-2 infection	88
Ligand Activation of PPARγ by Ligustrazine Suppresses Pericyte Functions of Hepatic Stellate Cells via SMRT-Mediated Transrepression of HIF-1α: Erratum	88
Piezo1 specific deletion in macrophage protects the progression of liver fibrosis in mice: Erratum	88
Endosome-microautophagy targeting chimera (eMIATAC) for targeted proteins degradation and enhance CAR-T cell anti-tumor therapy	87
Kir6.1/K-ATP channel in astrocytes is an essential negative modulator of astrocytic pyroptosis in mouse model of depression	85
CBX4 suppresses CD8⁺ T cell antitumor immunity by reprogramming glycolytic metabolism	85
Size-advantage of monovalent nanobodies against the macrophage mannose receptor for deep tumor penetration and tumor-associated macrophage targeting	84
Engineering of donor-acceptor-donor curcumin analogues as near-infrared fluorescent probes for in vivo imaging of amyloid-β species	84