OOIR: Observatory of International Research

Papers

(The H4-Index of Theranostics is 72. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
A transcriptional biosensor to monitor single cancer cell therapeutic responses by bioluminescence microscopy	601
Bispecific antibodies targeting EGFR/Notch enhance the response to talazoparib by decreasing tumour-initiating cell frequency	436
Young Bone Marrow Sca-1 Cells Rejuvenate the Aged Heart by Promoting Epithelial-to-Mesenchymal Transition: Erratum	369
Highly potent and selective PPARδ agonist reverses memory deficits in mouse models of Alzheimer's disease	344
The LMIT: Light-mediated minimally-invasive theranostics in oncology	215
Emerging microfluidics-enabled platforms for osteoarthritis management: from benchtop to bedside	212
Dopamine receptor 1 on CaMKII-positive neurons within claustrum mediates adolescent cocaine exposure-induced anxiety-like behaviors and electro-acupuncture therapy	208
Proteomes from AMPK-inhibited peripheral blood mononuclear cells suppress the progression of breast cancer and bone metastasis	196
Dual-targeted magnetic mesoporous silica nanoparticles reduce brain amyloid-β burden via depolymerization and intestinal metabolism	179
A FRET-based off-on AIE nanoprobe enables instant and stain-free detection of hypoxic niches in tumor sections	162
Nrf2 and HIF1α converge to arsenic-induced metabolic reprogramming and the formation of the cancer stem-like cells: Erratum	160
RNF138 regulates skeletal muscle differentiation via the Wnt/β-catenin signaling pathway	154
Molecular Imaging-Derived Biomarker of Cardiac Nerve Integrity — Introducing High NET Affinity PET Probe ¹⁸F-AF78	152
3D autofluorescence imaging of hydronephrosis and renal anatomical structure using cryo-micro-optical sectioning tomography	151
A bifunctional fusion membrane-based biocompatible nanovaccine to potentiate cancer immunotherapy	150
Transcriptome analysis reveals EBF1 ablation-induced injuries in cardiac system	147
A p-n heterojunction sonosensitizer for improved sono-immunotherapy via induction of multimodal cell death mechanisms	144
In vivo outer hair cell gene editing ameliorates progressive hearing loss in dominant-negative Kcnq4 murine model	140
Theranostics application of tumor-initiating cell probe TiY in non-small cell lung cancer	139
A low molecular weight multifunctional theranostic molecule for the treatment of prostate cancer	139
Human pluripotent stem cell-derived ectomesenchymal stromal cells promote more robust functional recovery than umbilical cord-derived mesenchymal stromal cells after hypoxic-ischaemic brain damage	134
ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold	131
High-fidelity imaging of amyloid-beta deposits with an ultrasensitive fluorescent probe facilitates the early diagnosis and treatment of Alzheimer's Disease	126
Targeted delivery of anti-miRNA21 sensitizes PD-L1^high tumor to immunotherapy by promoting immunogenic cell death	125
Bisecting GlcNAc modification reverses the chemoresistance via attenuating the function of P-gp	123

GPAT3 is a potential therapeutic target to overcome sorafenib resistance in hepatocellular carcinoma	122
Peptide receptor radionuclide therapy (PRRT) in metastatic neuroendocrine tumors of unknown primary (CUP-NETs)	119
AI-powered 3D pathology protocol enhances enteric nervous system visualization and quantification for clinical diagnostics	117
SPOP downregulation promotes bladder cancer progression based on cancer cell-macrophage crosstalk via STAT3/CCL2/IL-6 axis and is regulated by VEZF1	116
Recent progress of nano-drugs in neutron capture therapy	114
Betaine inhibits the stem cell-like properties of hepatocellular carcinoma by activating autophagy via SAM/m⁶A/YTHDF1-mediated enhancement on ATG3 stability	114
Tumor-derived EV miRNA signatures surpass total EV miRNA in supplementing mammography for precision breast cancer diagnosis	112
FGFR blockade boosts T cell infiltration into triple-negative breast cancer by regulating cancer-associated fibroblasts	105
Targeting cancer with precision: strategical insights into TCR-engineered T cell therapies	102
Stimulation by exosomes from hypoxia-preconditioned hair follicle mesenchymal stem cells facilitates mitophagy by inhibiting the PI3K/AKT/mTOR signaling pathway to alleviate ulcerative colitis	102
5-Aminolevulinate improves metabolic recovery and cell survival of the liver following cold preservation	98
Multifunctional metal-organic framework (MOF)-based nanoplatforms for cancer therapy: from single to combination therapy	98
The emerging role of Piezo1 in the musculoskeletal system and disease	98
Towards effective CAIX-targeted radionuclide and checkpoint inhibition combination therapy for advanced clear cell renal cell carcinoma	97
Noninvasive closed-loop acoustic brain-computer interface for seizure control	96
A multifunctional injectable microsphere with enhanced near-infrared photo-antibacterial, ROS scavenging, and anti-inflammatory properties for periodontitis treatment	95
Ferritin light chain promotes the reprogramming of glioma immune microenvironment and facilitates glioma progression	94
Current advances in temozolomide encapsulation for the enhancement of glioblastoma treatment	94
Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms	94
Comprehensive omics analyses profile genesets related with tumor heterogeneity of multifocal glioblastomas and reveal LIF/CCL2 as biomarkers for mesenchymal subtype	93
Discovery of novel antibacterial agent for the infected wound treatment: all-hydrocarbon stapling optimization of LL-37	93
FUNDC1 alleviates doxorubicin-induced cardiotoxicity by restoring mitochondrial-endoplasmic reticulum contacts and blocked autophagic flux	91
Cell-membrane-coated nanoparticles for the fight against pathogenic bacteria, toxins, and inflammatory cytokines associated with sepsis	90
Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging: Erratum	88
Surface-engineered extracellular vesicles for targeted delivery of therapeutic RNAs and peptides for cancer therapy	88
Perfluorocarbon-polyepinephrine core-shell nanoparticles as a near-infrared light activatable theranostic platform for bimodal imaging-guided photothermal/chemodynamic synergistic cancer therapy	88
Minimally invasive implantation and decreased inflammation reduce osteoinduction of biomaterial: Erratum	86
Piezo1 specific deletion in macrophage protects the progression of liver fibrosis in mice: Erratum	84
Ligand Activation of PPARγ by Ligustrazine Suppresses Pericyte Functions of Hepatic Stellate Cells via SMRT-Mediated Transrepression of HIF-1α: Erratum	83
Endosome-microautophagy targeting chimera (eMIATAC) for targeted proteins degradation and enhance CAR-T cell anti-tumor therapy	83
A Transferrin-Conjugated Hollow Nanoplatform for Redox-Controlled and Targeted Chemotherapy of Tumor with Reduced Inflammatory Reactions: Erratum	83
KMV-mediated cardiomyocyte-to-endothelial cell signaling drives capillary rarefaction to promote heart failure following pressure overload	82
Platelet membrane decorated exosomes enhance targeting efficacy and therapeutic index to alleviate arterial restenosis	82
Kir6.1/K-ATP channel in astrocytes is an essential negative modulator of astrocytic pyroptosis in mouse model of depression	81
The combination of calreticulin-targeting L-ASNase and anti-PD-L1 antibody modulates the tumor immune microenvironment to synergistically enhance the antitumor efficacy of radiotherapy	81
TRIB1 regulates tumor growth via controlling tumor-associated macrophage phenotypes and is associated with breast cancer survival and treatment response	80
Identification of early invisible acute ischemic stroke in non-contrast computed tomography using two-stage deep-learning model	79
Size-advantage of monovalent nanobodies against the macrophage mannose receptor for deep tumor penetration and tumor-associated macrophage targeting	78
Weak acid-initiated slow release of Dexamethasone from hydrogel to treat orbital inflammation	78
First-in-human study of an optimized, potential kit-type, SSTR antagonist ⁶⁸Ga-DATA^5m-LM4 in patients with metastatic neuroendocrine tumors	77
Unlocking the dual role of LSD1 in tumor immunity: innate and adaptive pathways	76
Inhibiting the activation of MAPK (ERK1/2) in stressed Müller cells prevents photoreceptor degeneration	76
Resveratrol ameliorates polycystic ovary syndrome via transzonal projections within oocyte-granulosa cell communication	76
Dual-Targeted Gold Nanoprism for Recognition of Early Apoptosis, Dual-Model Imaging and Precise Cancer Photothermal Therapy: Erratum	74
Developing an efficient MGCR microneedle nanovaccine patch for eliciting Th 1 cellular response against the SARS-CoV-2 infection	73
Twist1 downregulation of PGC-1α decreases fatty acid oxidation in tubular epithelial cells, leading to kidney fibrosis: Erratum	73
NAD⁺-boosting molecules suppress mast cell degranulation and anaphylactic responses in mice	72
Programmatically activated DNA hydrogel microcapsules for precision therapy in inflammatory bowel disease	72
Comprehensive machine learning-generated classifier identifies pro-metastatic characteristics and predicts individual treatment in pancreatic cancer: A multicenter cohort study based on super-enhancer	72