OOIR: Observatory of International Research

Papers

(The median citation count of ChemMedChem is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Fluorinated High‐Valent Sn(IV) Porphyrins Show Remarkable Photodynamic Activity in Cancer Cells	209
	116
Nicorandil Repurposing in Orofacial Pain: Preclinical Findings in Adult Zebrafish	79
Importance of Co‐operative Hydrogen Bonding in the Apramycin‐Ribosomal Decoding A‐Site Interaction	75
	71
Front Cover: Design Principles for Balancing Lipophilicity and Permeability in beyond Rule of 5 Space (ChemMedChem 5/2024) (ChemMedChem 5/2024)	65
Scouting Different Phosphodiesterase 4 Inhibitor Chemotypes in Silico To Guide the Design of Anti‐inflammatory/Antioxidant Agents	60
Design and Synthesis of 1,3‐Diynes as Potent Antifungal Agents against Aspergillus fumigatus	58
	53
Phosphate‐Containing Glycolipids: A Review on Synthesis and Bioactivity	50
Anti‐Sporothrix Activity of Novel Copper‐Itraconazole Complexes	50
Designing Cyclic Nitrogen‐Bridged Sulfonamides with Anti‐Cancer Activity	48
Front Cover: (ChemMedChem 12/2025)	47
“Cofactors” for Natural Products	47
CYP3A4 Catalyzes the Rearrangement of the Dual Orexin Receptor Antagonist Daridorexant to 4‐Hydroxypiperidinol Metabolites	45
Front Cover: Covalent Allosteric Inhibitors of Akt Generated Using a Click Fragment Approach (ChemMedChem 10/2022)	45
Quantum Osteoimmunology: A Paradigm Shift in Understanding and Influencing Bone–Immune Crosstalk	44
C9‐Functionalized Doxycycline Analogs as Drug Candidates to Prevent Pathological α‐Synuclein Aggregation and Neuroinflammation in Parkinson's Disease Degeneration	41
Insights into the Overcoming EGFR^{Del19/T790M/C797S} Mutation: A Perspective on the 2‐Aryl‐4‐aminothienopyrimidine Backbone	38
Late‐Stage Diversification of Pyrazoles as Antileishmanial Agents	34
Adsorption to the Surface of Hemozoin Crystals: Structure‐Based Design and Synthesis of Amino‐Phenoxazine β‐Hematin Inhibitors	33
Substituted Benzylidene‐3‐Oxo‐3,4‐Dihydro‐2 H ‐Benzo[ b ][1,4]thiazine‐6‐Carboxylic Acid Analogs as Dynami	30
An Active Member of the EFMC: The Division of Medicinal Chemistry and Chemical Biology of the Swiss Chemical Society**	30
Hepatic‐Targeted Nano‐enzyme with Resveratrol Loading for Precise Relief of Nonalcoholic Steatohepatitis	30
API‐ILs Ionic Adducts: Solubility and Surface Activity Properties—En Route to New Paradigm in Drug Development	29

Chemical Design Strategy of Ionizable Lipids for In Vivo mRNA Delivery	29
Cyclin‐Dependent Kinase 11: Cellular Functions and Potential Therapeutic Applications	28
Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4	27
Optimization of Ketobenzothiazole‐Based Type II Transmembrane Serine Protease Inhibitors to Block H1N1 Influenza Virus Replication	27
Mass Spectrometric Assays Reveal Discrepancies in Inhibition Profiles for the SARS‐CoV‐2 Papain‐Like Protease	26
Generation of Molecular Counterfactuals for Explainable Machine Learning Based on Core‐Substituent Recombination	26
Incorporation of Trifluoromethyltriazoline in the Side Chain of 4‐Aminoquinolines: Synthesis and Evaluation as Antiplasmodial Agents	25
Excited State and Reactive Oxygen Species against Cancer and Pathogens: A Review on Sonodynamic and Sono‐Photodynamic Therapy	25
Fluorescence‐Based Detection of Methionine for Noninvasive Cancer Diagnosis Using Cu–Sn Bimetallic Nanoclusters	25
Benocyclidine (BTCP) as Non‐labelled Reporter Ligand for MS Binding Assays for the PCP Ion Channel Binding Site of the Desensitized Torpedo Nicotinic Acetylcholine Receptor (nAChR)	24
Covalent Fragment Screening Identifies Rgl2 RalGEF Cysteine for Targeted Covalent Inhibition of Ral GTPase Activation	24
Front Cover: 3’‐Dehydroxypurpurogallin‐4‐Carboxamides as Influenza A Endonuclease Inhibitors: Synthesis, Structure‐Activity Relationship Analysis, and Structural Characterization of Protein Complex (C	23
Evaluation of a Radiolabeled Macrocyclic Peptide as Potential PET Imaging Probe for PD−L1	23
Asparagusic Acid – A Unique Approach toward Effective Cellular Uptake of Therapeutics: Application, Biological Targets, and Chemical Properties	23
Ultrasound‐Assisted Synthesis of Pyrazoline Derivatives as Potential Antagonists of RAGE‐Mediated Pathologies: Insights from SAR Studies and Biological Evaluations	23
Isolation of a Natural Killer Group 2D Small‐Molecule Ligand from DNA‐Encoded Chemical Libraries	23
Discovery of Truncated Cyclic Peptides Targeting an Induced‐Fit Pocket on PCSK9	23
Investigating the C2 Modulation of the Imidazo[1,2‐a]pyrazine‐Based Hit Compound CTN1122: Synthesis, in vitro Antileishmanial Activity, Cytotoxicity and Casein Kinase 1 Inhibition	23
	23
Front Cover: Structure‐Activity Relationships, Tolerability and Efficacy of Microtubule‐Active 1,2,4‐Triazolo[1,5‐a]pyrimidines as Potential Candidates to Treat Human African Trypanosomiasis (C	22
Front Cover: Cyclic Octapeptides Composed of Two Glutathione Units Outperform the Monomer in Lead Detoxification (ChemMedChem 15/2022)	21
Exploiting the 5‐Amino‐11H‐Indolo[3,2‐c]isoquinoline Core to Achieve Better G‐Quadruplex Ligands for Cancer Therapy	21
Novel Quinazolinones Active against Multidrug‐Resistant Mycobacterium Tuberculosis: Synthesis, Antimicrobial Evaluation, and in Silico Exploration of Penicillin‐Binding Protein 1A as a Potentia	21
Expanding the Repertoire of Low‐Molecular‐Weight Pentafluorosulfanyl‐Substituted Scaffolds	21
	21
Selectfluor‐Mediated Chlorination and Fluorination of Arenes: Late‐Stage Functionalization of APIs and Its Biological Effects	20
Front Cover: A Promising Approach to Target Colorectal Cancer Using Hybrid Triarylmethanes (ChemMedChem 21/2024)	20
Nonsteroidal Anti‐Inflammatory Drugs as Modulators of Cation Channels: Fenamates Repurposing in Channelopathies	20
Effective Anticancer Potential of a New Sulfonamide as a Carbonic Anhydrase IX Inhibitor Against Aggressive Tumors	20
Andrographolide Derivatives Target the KEAP1/NRF2 Axis and Possess Potent Anti‐SARS‐CoV‐2 Activity	19
Total Synthesis and Antibacterial Investigations of 1‐Hydroxyboivinianin A	19
Development of C646‐Based Proteolysis Targeting Chimeras Degraders of the Lysine Acetyltransferases CBP and p300	19
Intracellular Delivery of Antibodies for Selective Cell Signaling Interference	19
E‐64c‐Hydrazide Based Cathepsin C Inhibitors: Optimizing the Interactions with the S1’‐S2’ Area	18
Selenocarbamates As a Prodrug‐Based Approach to Carbonic Anhydrase Inhibition	18
Aspirin‐Conjugated Cholic Acid Derivative Combats Polymicrobial Infections and Inflammation	18
Development of New Benzo[ b ]Thiophene‐2‐Carboxamide Derivatives as Advanced Glycation End‐Products Receptor (RAGE) Antagonists	18
Modifications to a Biphenolic Antibacterial Compound: Activity against ESKAPE Pathogens	17
Nucleoside Derivatives of 2,6‐Diaminopurine Antivirals: Base‐Modified Nucleosides with Broad‐Spectrum Antimicrobial Properties	17
Investigating the Ligand‐Binding Properties of N‐arylbenzimidazoles as Novel Elastase Inhibitors	17
Advanced Hydrogels: Enhancing Tissue Bioengineering with RGD Peptides and Carbon Nanomaterials	17
Mitochondria‐Targeting Metallodrugs for Cancer Therapy: Perspectives from Cell Death Modes	17
Design and Synthesis of Oligopeptidic Parvulin Inhibitors	17
Targeting Tetraspanins at Cell Interfaces: Functional Modulation and Exosome‐Based Drug Delivery for Precise Disease Treatment	16
Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites	16
Isoniazid‐Dihydropyrimidinone Molecular Hybrids: Design, Synthesis, Antitubercular Activity, and Cytotoxicity Investigations with Computational Validation	16
Antiplasmodial and Antimalarial Activity of 3,5‐Diarylidenetetrahydro‐2H‐pyran‐4(3H)‐ones via Inhibition of Plasmodium falciparum Pyridoxal Synthase	16
Development of Keap1‐Nrf2 Protein–Protein Interaction Inhibitor Activating Intracellular Nrf2 Based on the Naphthalene‐2‐acetamide Scaffold, and its Anti‐Inflammatory Effects	16
Neuroblastoma and its Target Therapies: A Medicinal Chemistry Review	16
Exploring Raloxifene‐Based Metallodrugs: A Versatile Vector Combined with Platinum(II), Palladium(II) and Nickel(II) Dichlorides and Carborates against Triple‐Negative Breast Cancer	16

Antimalarial and Anticancer Activity Evaluation of Bridged Ozonides, Aminoperoxides, and Tetraoxanes	16
Factors Affecting Liquid‐Liquid Phase Separation of RGG Peptides with DNA G‐Quadruplex	16
	15
Pantinin‐Derived Peptides against Veterinary Herpesviruses: Activity and Structural Characterization	15
Towards the Use of Metabolic Volatiles in Breath for Determining Drug Response: Gstachamine as an Unlabeled Substrate to Measure CYP3A4 Activity	15
Front Cover: Conception and Evaluation of Fluorescent Phosphine‐Gold Complexes: From Synthesis to in vivo Investigations (ChemMedChem 11/2022)	15
LIN28‐Targeting Chromenopyrazoles and Tetrahydroquinolines Induced Cellular Morphological Changes and Showed High Biosimilarity with BRD PROTACs	15
Chemo‐enzymatic Synthesis of Pseudo‐trisaccharide Aminoglycoside Antibiotics with Enhanced Nonsense Read‐through Inducer Activity	14
	14
Synthesis and in vitro Study of Artemisinin/Synthetic Peroxide‐Based Hybrid Compounds against SARS‐CoV‐2 and Cancer	14
Piperazine‐Modified Ketoconazole Derivatives Show Increased Activity against Fungal and Trypanosomatid Pathogens	14
Front Cover: Interaction of a Jaundice Marker Molecule with a Redox‐Modulatory Nano‐Hybrid: A Combined Electrochemical and Spectroscopic Study toward the Development of a Theranostic Tool (ChemMedChem	14
Subnanomolar Cathepsin S Inhibitors with High Selectivity: Optimizing Covalent Reversible α‐Fluorovinylsulfones and α‐Sulfonates as Potential Immunomodulators in Cancer	14
Inhibition of Human Cholinesterases and in vitro β‐Amyloid Aggregation by Rationally Designed Peptides	14
Front Cover: Synthesis of Unsymmetrical Squaramides as Allosteric GSK‐3β Inhibitors Promoting β‐Catenin‐Mediated Transcription of TCF/LEF in Retinal Pigment Epithelial Cells (ChemMedChem 24/2022)	14
Front Cover: Chemically Diverse S. mansoni HDAC8 Inhibitors Reduce Viability in Worm Larval and Adult Stages (ChemMedChem 3/2023)	14
Discovery of Novel Aminopyrimidines as Selective EP2 Receptor Antagonists	14
Improving the Photodynamic Activity of Water‐Soluble Porphyrin–Polysaccharide Complexes by Folic Acid Modification	14
Synthesis and Biological Evaluation of Cardiac Glycosides for Cancer Therapy by Targeting the DNA Damage Response	14
Front Cover: Optimization of N‐Piperidinyl‐Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8‐Oxo‐Guanine DNA Glycosylase 1 (ChemMedChem 1/2023)	13
Progress of Mesoporous Silica Coated Gold Nanorods for Biological Imaging and Cancer Therapy	13
Corrigendum: Promising Therapeutic Approach for SARS‐CoV‐2 Infections by Using a Rutin‐Based Combination Therapy	13
Virtual Screening and Biological Evaluation of Natural Products as Novel VPS34 Inhibitors that Modulate Autophagy	13
Benzofuran and Benzo[b]thiophene‐2‐Carboxamide Derivatives as Modulators of Amyloid Beta (Aβ42) Aggregation	13
	12
Deciphering the Binding Insights of Novel Disubstituted Anthraquinone Derivatives with G‐Quadruplex DNA to Exhibit Selective Cancer Cell Cytotoxicity	12
Design, Synthesis and Preliminary Bioactivity Evaluation of N‐Acetylcysteine Derivatives as Antioxidative and Anti‐Inflammatory Agents	12
Screening and Synthesis of Tetrazole Derivatives that Inhibit the Growth of Cryptococcus Species	12
Design and Synthesis of ⁶⁸Ga‐Labeled Peptide‐Based Heterodimers for Dual Targeting of NTS₁ and GRPR	12
Potent Inhibition of Bacterial DNA Gyrase by Digallic Acid and Other Gallate Derivatives	12
The Therapeutic Potential in Cancer of Terpyridine‐Based Metal Complexes Featuring Group 11 Elements	12
Acetic Acid‐Driven One‐Pot Synthesis of 4,7‐dihydro‐[1,2,3]thiadiazolo[5,4‐b]pyridine‐6‐carboxamides and Pharmacological Evaluations	12
Small‐Molecule Sarco/Endoplasmic Reticulum Ca ²⁺ ‐ATPase Activators Reverse Methylglyoxal‐Induced Inhibition through Nonantioxidant Mechanisms	12
Ru‐Based Organometallic Agents Bearing Phenyl Hydroxide: Synthesis and Antibacterial Mechanism Study against Staphylococcus aureus	12
Coumarin‐Caged Nanoparticle for Light‐Driven Surface Modification	11
2‐Difluoromethoxy‐Substituted Estratriene Sulfamates: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Steroid Sulfatase Inhibition	11
Diversity Oriented Strategy (DOS) for the Efficient Synthesis of Benzofuro[2,3‐b]pyridine Derivatives with Anticancer Activity	11
Chemically Tuned Intracellular Gene Delivery by Core‐Shell Nanoparticles: Effects of Proton Buffering, Acid Degradability, and Membrane Disruption	11
Synthesis and Characterization of a New Cationic Lipid: Efficient siRNA Delivery and Anticancer Activity of Survivin‐siRNA Lipoplexes for the Treatment of Lung and Breast Cancers**	11
Recent Advances in Mitochondria‐Localized Luminescent Ruthenium(II) Metallodrugs as Anticancer Agents	11
Transition Metal Complexes with Tridentate Schiff Bases (O N O and O N N) Derived from Salicylaldehyde: An Analysis of Their Potential Anticancer Activity	11
Enhancing Stability and Entrapment Efficiency of Liposome‐Coated Mesoporous Silica Nanocarriers Using Polyoxyethylene Alkyl Ether as a Polyethylene Glycol Anchoring Agent	11
Evaluating Bis‐Phenacyl Bromide‐Based Bis‐Heterocyclic Templates as Anticancer Prototypes and Potential PARP1 Inhibitors	11
Design, Synthesis, and Biological Evaluation of Histone Deacetylase Inhibitors Derived from Erianin and Its Derivatives	11
Scaffold Hopping from Amodiaquine to Novel Nurr1 Agonist Chemotypes via Microscale Analogue Libraries	11
In vivo Structure‐Activity Relationship of Dihydromethysticin in Reducing Nicotine‐Derived Nitrosamine Ketone (NNK)‐Induced Lung DNA Damage against Lung Carcinogenesis in A/J Mice	11
Small‐Molecule Inhibitors Targeting PD‐1/PD‐L1 in Colorectal Cancer: Mechanisms, Challenges, and Clinical Prospects	11
Carbon Dots as Bioactive Antifungal Nanomaterials	11
Monodentate Phosphine Modulation in Cyclometallated Platinum(II) Complexes for Antileishmanial, Antiviral, and Antitumor Applications	11
	11
Design, Synthesis, and Biological Characterization of Macromolecular Ester Prodrugs of a Selective Cyclooxygenase‐2 Inhibitor	11
Out of the Dark, into the Light: Metabolic Fluorescent Labeling of Nucleic Acids	11
An Interdisciplinary Approach Provides Insights into the Pronounced Selectivity of Compound 42 for DPP9	10
Anti‐Carbonic Anhydrase Goldbodies by Conformational Reconstruction of the Complementary‐Determining Regions of Phage‐Displayed Antibodies	10
Boosting the Impact of EFMC Young Scientists Network Through the Creation of Working Groups	10
Synthesis and Structural Characterization of Macrocyclic Plasmin Inhibitors	10
Benzoxazoles Derived from Eugenol as Potential Agents against Arboviruses: Synthesis, Antiviral Studies, and Mechanistic Insights	10
The French Medicinal Chemistry Society–SCT, an Historical Member of EFMC**	10
Cyclic Octapeptides Composed of Two Glutathione Units Outperform the Monomer in Lead Detoxification	10
Design, Synthesis, and Evaluation of Boron Dipyrromethene‐Based Fluorescent Probes Targeting BRAF for Melanoma Diagnosis	10
Phloroglucinol Derivatives Exert Anti‐Inflammatory Effects and Attenuate Cognitive Impairment in LPS‐Induced Mouse Model	10
Emerging Trends in Quinoxaline‐Based Analogs as Protein Kinase Inhibitors: Structural Developments and SAR Insights	10
Front Cover: Structural Basis of Saccharin Derivative Inhibition of Carbonic Anhydrase IX (ChemMedChem 22/2023)	10
Mitochondria‐Targeted Triphenylphosphonium Conjugated C‐3 Modified Betulin: Synthesis, Antitumor Properties and Mechanism of Action	10
Front Cover: When Two Become One: Conformational Changes in FXR/RXR Heterodimers Bound to Steroidal Antagonists (ChemMedChem 4/2023)	10
	10
Harnessing Chemical Diversity to Disarm Bacterial Communication for 25 Years: Natural Products, Repurposed Drugs, Peptides, and Synthetic Quorum Sensing Inhibitors	10
Current Small Molecule–Based Medicinal Chemistry Approaches for Neurodegeneration Therapeutics	10
Spiro‐Acridine Compound as a Pteridine Reductase 1 Inhibitor: in silico Target Fishing and in vitro Studies	10
Front Cover: Single Modification at the N‐Terminus of Norvancomycin to Combat Drug‐Resistant Gram‐Positive Bacteria (ChemMedChem 9/2023)	10
Membrane Proteins in Nanodiscs: Methods and Applications	10
	10
Front Cover: Beyond the Toll‐Like Receptor 4. Structure‐Dependent Lipopolysaccharide Recognition Systems: How far are we? (ChemMedChem 6/2025)	10
Corrigendum: Asparagusic Acid – A Unique Approach toward Effective Cellular Uptake of Therapeutics: Application, Biological Targets, and Chemical Properties	10
Emerging Roles of Gossypol in Therapy: Innovations in Prodrug Design and Nanoformulation Frontiers	10
Design, Synthesis and Biological Evaluation of Ethyl 5‐(1‐benzyl‐1H‐indol‐5‐yl) Isoxazole‐3‐Carboxylates as Antimycobacterial Agents	10
Recent Progress in Prompt Molecular Detection of Exosomes Using CRISPR/Cas and Microfluidic‐Assisted Approaches Toward Smart Cancer Diagnosis and Analysis	10
Corrigendum: Drug Repurposing for the SARS‐CoV‐2 Papain‐Like Protease	10
Tetrahydroindolone‐Dihydropyrimidinone Hybrids as Promising Antibiofilm and Antibacterial Agents	10
Zwitterionic Polymer: A New Paradigm for Protein Conjugation beyond PEG	9

Adipocyte‐Targeted Nanotechnology and Cell‐Based Therapy for Obesity Treatment	9
Investigation of Muscarinic Acetylcholine Receptor M₃ Activation in Atomistic Detail: A Chemist's Viewpoint	9
Cover Feature: How Should we Teach Medicinal Chemistry in Higher Education to Prepare Students for a Future Career as Medicinal Chemists and Drug Designers? – A Teacher's Perspective (ChemMedChem 2/20	9
Targeting Cell division cycle 37: A Promising Novel Therapeutic Strategy	9
	9
Identification of Balanol As a Potential Inhibitor of PAK1 That Induces Apoptosis and Cytoprotective Autophagy in Colorectal Cancer Cells	9
Exploring the Impact of C‐Terminal Based Pentapeptides on the Disassembly of Aβ₄₂ Fibrils	9
Peptide Assemblies for Cancer Therapy	9
Front Cover: Incubation of Amyloidogenic Peptides in Reverse Micelles Allow Active Control of Oligomer Size and Study of Protein–Protein Interactions (ChemMedChem 23/2024)	9
Small Molecule‐Drug Conjugates: Opportunities for the Development of Targeted Anticancer Drugs	9
Design, Synthesis, and Xanthine Oxidase Inhibitory Activity of 4‐(5‐Aminosubstituted‐4‐cyanooxazol‐2‐yl)benzoic Acids	9
Machine Learning‐Driven QSAR Modeling of Anticancer Activity from a Rationally Designed Synthetic Flavone Library	9
Opioid Ligands Addressing Unconventional Binding Sites and More Than One Opioid Receptor Subtype	9
Enhancing Targeted Drug Delivery through Cell‐Specific Endosomal Escape	9
Spirooxindol‐1,3‐oxazine Alkaloids: Highly Potent and Selective Antitumor Agents Evolved from Iterative Structure Optimization	9
Front Cover: Efficient Synthesis of Benzothiazinone Analogues with Activity against Intracellular Mycobacterium tuberculosis (ChemMedChem 6/2022)	9
Structure‐Activity Relationships of Flupirtine Analogues for Liver Esterase‐Mediated Cleavage of the 4‐Fluorobenzylamine Moiety and Its Possible Relevance to Liver Toxicity	9
Fluorinated Cycloalkyl Building Blocks for Drug Discovery	9
Histidinal‐Based Potent Antimalarial Agents	9
Unveiling Gelation and Antimicrobial Potentials of α‐Acyloxy Carboxamides: Findings from Experimental and Theoretical Approach	9
Machine Learning Guided Discovery of Non‐Hemolytic Membrane Disruptive Anticancer Peptides	9
The Chemerin Receptor CMKLR1 Requires Full‐Length Chemerin for High Affinity in Contrast to GPR1 as Demonstrated by a New Nanoluciferase‐Based Binding Assay	9
Front Cover: Total Synthesis of Antiausterity Agent Callistrilone O Reveals Promising Antitumor Activity in a Melanoma Homograft Mouse Model (ChemMedChem 7/2025)	9
Sulforaphane is Synergistic with CB‐5083 and Inhibits Colony Formation of CB‐5083‐Resistant HCT116 Cells	9
Structure and Dynamics of Monoclonal Antibody Domains Using Spins, Scattering, and Simulations	9
Discovery and in vitro Evaluation of Novel Serotonin 5‐HT_2A Receptor Ligands Identified Through Virtual Screening	9
Modification of Biphenolic Anti‐Bacterial to Achieve Broad‐Spectrum Activity	9
	9
Front Cover: Discovery of Benzo[d]imidazole‐6‐sulfonamides as Bromodomain and Extra‐Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain (ChemMedChem 20/2022)	9
Deriving Novel Quaternary Ammonium Compound Disinfectant Scaffolds from a Natural Product: Mechanistic Insights of the Quaternization of Ianthelliformisamine C	9
Inflammaging and Immunosenescence in the Post‐COVID Era: Small Molecules, Big Challenges	9
Programmable Intelligent DNA Nanoreactors (iDNRs) for in vivo Tumor Diagnosis and Therapy	9
Investigation of Novel Isatinylhydantoin Derivatives as Potential Anti‐Kinetoplastid Agents	8
Synthesis of a Gemcitabine Prodrug and its Encapsulation into Polymeric Nanoparticles for Improved Therapeutic Efficacy	8
Inhibition Studies on Carbonic Anhydrase Isoforms I, II, IX, and XII with a Series of Sulfaguanidines	8
A Pleiotropic Nanomedicine Mitigates Splenic Hyperplasia, Ineffective Erythropoiesis, G6PDH Anomaly through Redox Buffering in Preclinical Mice Model	8
A Neutral and Stable Macrocyclic Mn(II) Complex for MRI Tumor Visualization	8
Front Cover: Complex pBAE Nanoparticle Cell Trafficking: Tracking Both Position and Composition Using Super Resolution Microscopy (ChemMedChem 13/2022)	8
	8
Cellular Effects of Cationic Copper(II) Schiff Base Complexes: Anti‐Inflammatory and Antiproliferative Properties	8
Design and Synthesis of Novel 2‐Acetamido, 6‐Carboxamide Substituted Benzothiazoles as Potential BRAFV600E Inhibitors – In vitro Evaluation of their Antiproliferative Activity	8
Water‐Soluble Fullerene Monoderivatives for Biomedical Applications	8
Hexafluoroisopropyl Carbamates as Selective MAGL and Dual MAGL/FAAH Inhibitors: Biochemical and Physicochemical Properties	8
How Should we Teach Medicinal Chemistry in Higher Education to Prepare Students for a Future Career as Medicinal Chemists and Drug Designers? – A Teacher's Perspective	8
Beyond the Toll‐Like Receptor 4. Structure‐Dependent Lipopolysaccharide Recognition Systems: How far are we?	8
Harnessing the Sulfur‐for‐Oxygen Shift: A Magic Bullet for Dynamic Photophysical and Anticancer Activities of Indole‐Barbituric Acid Construct	8
[1,2,4]Triazolo[1,5‐c]pyrimidines as Tools to Investigate A₃ Adenosine Receptors in Cancer Cell Lines	8
Impact of Chelation on Reactivity and Cytotoxicity of Hemilabile Biphenyl Gold(III) N‐Heterocyclic Carbene Complexes	8
Front Cover: Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance (ChemMedChem 2/2023)	8
Structural Development of Silicon‐Containing Retinoids: Structure–Activity Relationship Study of the Hydrophobic Pharmacophore of Retinobenzoic Acids Using Silyl Functionalities	8
Aminocholestane and Aminoandrostane Inhibitors of the SH2 Domain‐Containing Inositol 5’‐Phosphatase (SHIP)	8
Recent Drug Development and Medicinal Chemistry Approaches for the Treatment of SARS‐CoV‐2 Infection and COVID‐19	8
A Series of Thiadiazolyl‐Benzenesulfonamides Incorporating an Aromatic Tail as Isoform‐Selective, Potent Carbonic Anhydrase II/XII Inhibitors	8
Proteolysis Targeting Chimeras (PROTACs) in Breast Cancer Therapy	8
Glyoxalase‐1 Inhibition Leads to Ferroptosis Induction in Lung Cancer Cells: A Dual Mechanism of Action of Hydroxamic Acids Derived from Cysteine	8
Screening Methods for Cervical Cancer	8
Discovery of (2‐(4‐Substituted phenyl)quinolin‐4‐yl)(4‐isopropylpiperazin‐1‐yl)methanone Derivatives as Potent Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors	8
Synthesis and Biological Characterization of 4,4‐Difluoro‐3‐(phenoxymethyl)piperidine Scaffold as Dopamine 4 Receptor (D₄R) Antagonist in vitro Tool compounds	8
N,N‐Diarylsulfonamide Reduces Proinflammatory Cytokine Interleukin‐6 Levels in Cells through Nuclear Factor‐κB Regulation	8
Rational Design of Novel Allosteric EYA2 Inhibitors as Potential Therapeutics for Multiple Brain Cancers	8
Identification of Potential Inhibitors of the SARS‐CoV‐2 NSP13 Helicase via Structure‐Based Ligand Design, Molecular Docking and Nonequilibrium Alchemical Simulations	8
Multidisciplinary Preclinical Investigations on Ferrocenyl, Ruthenocenyl, and Benzyl Derivatives of Niridazole as New Drug Candidates against Schistosomiasis	8
Promising Therapeutic Approach for SARS‐CoV‐2 Infections by Using a Rutin‐Based Combination Therapy	8
Synthesis of 1,2,3‐Triazole‐Methyl‐Menadione Derivatives: Evaluation of Electrochemical and Antiparasitic Properties against two Blood‐Dwelling Parasites	8
Machine Learning‐Driven Discovery of Structurally Related Natural Products as Activators of the Cardiac Calcium Pump SERCA2a	8
Chemical and Chemoenzymatic Synthesis of Peptide and Protein Therapeutics Conjugated with Human N‐Glycans	8
	7
Evaluation of Rhodanine Indolinones as AANAT Inhibitors	7
Structure–Property Associations: Breaking Paradigms for Linking Chemical Structures and Biological Properties in Drug Discovery	7
AgamOBP1‐Directed Discovery of Repellents to Control the Spread of Mosquito‐Borne Diseases	7
Nature‐Inspired MYC Inhibitor Disrupts MYC‐Driven Glycolysis and Restricts Ovarian Tumor Growth	7
Copper‐Induced Supramolecular Assemblies for Biomedical Applications	7
Elucidating the Unconventional Binding Mode of a DNA‐Encoded Library Hit Provides a Blueprint for Sirtuin 6 Inhibitor Development	7
Advances in Diclofenac Derivatives: Exploring Carborane‐Substituted N‐Methyl and Nitrile Analogs for Anticancer Therapy	7
Thiazole‐Based IL‐17 Inhibitors Discovered by Scaffold Morphing	7
Synthesis, Characterization and in vitro Anticancer Evaluation of 5‐Sulfinyl(sulfonyl)‐4‐arylsulfonyl‐Substituted 1,3‐Oxazoles	7
Ideas Behind the Tryptophan‐Mediated Petasis Reaction (TMPR) Concept for Peptide Stapling	7
Developing Dynamic Structure‐Based Pharmacophore and ML‐Trained QSAR Models for the Discovery of Novel Resistance‐Free RET Tyrosine Kinase Inhibitors Through Extensive MD Trajectories and NRI Analysis	7
Design of Dual EP2/EP4 Antagonists through Scaffold Merging of Selective Inhibitors	7
Carborane‐Based Tebufelone Analogs and Their Biological Evaluation In Vitro	7
Corrigendum: A Study of the Activity of Adamantyl Amines against Mutant Influenza A M2 Channels Identified a Polycyclic Cage Amine Triple Blocker, Explored by Molecular Dynamics Simulations and Solid‐	7
AMPK Activation by 2′‐Hydroxy‐2,4,5‐Trimethoxychalcone Derivatives in Podocyte Cells	7
Front Cover: Structure‐Based Drug Design of Novel Heterocyclic Scaffolds as TgCDPK1 Inhibitors (ChemMedChem 18/2025)	7
Anticancer Activities of Tetrasubstituted Imidazole‐Pyrimidine‐Sulfonamide Hybrids as Inhibitors of EGFR Mutants	7
New Indole‐Based Phenylthiazolyl‐2,4‐dihydropyrazolones as Tubulin polymerization inhibitors: Multicomponent Synthesis, Cytotoxicity Evaluation, and in silico Studies	7
Chemical Derivatization Leads to the Discovery Of Novel Analogs of Azotochelin, a Natural Siderophore, as Promising Anticancer Agents	7
Chimeric Amphiphilic Disinfectants: Quaternary Ammonium/Quaternary Phosphonium Hybrid Structures	7
Development of a Partial Proteolysis Targeting Chimera Library Based on Achiral Cereblon E3 Ligase Ligands and its Application for Bruton's Tyrosine Kinase Degraders	7
The Hydrazine Moiety in the Synthesis of Modified Nucleosides and Nucleotides	7
N‐Heterocyclic Carbene (NHC) Silver Complexes as Versatile Chemotherapeutic Agents Targeting Human Topoisomerases and Actin	7
Frontiers in Medicinal Chemistry 2022 Goes Virtual	7
3′‐Dehydroxypurpurogallin‐4‐Carboxamides as Influenza A Endonuclease Inhibitors: Synthesis, Structure–Activity Relationship Analysis, and Structural Characterization of Protein Complex	7
Tetrahydrofuran‐Containing Pharmaceuticals: Targets, Pharmacological Activities, and their SAR Studies	7
C7‐Halomethylene/methyl‐C3‐thiophenyl‐spirocyclic‐β‐lactams: Synthesis, X‐ray Analysis, Antimicrobial Evaluation, Cytotoxicity Profile and Molecular Docking Interactions	7
Exploring Derivatives of Quinolizidine Alkaloid Sophoridine in the Design and Biological Mechanistic Evaluation of Histone Deacetylase Inhibitors against Triple‐Negative Breast Cancer	7