OOIR: Observatory of International Research

Papers

(The median citation count of ChemMedChem is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Quantum Osteoimmunology: A Paradigm Shift in Understanding and Influencing Bone–Immune Crosstalk	190
Cyclin‐Dependent Kinase 11: Cellular Functions and Potential Therapeutic Applications	121
Adsorption to the Surface of Hemozoin Crystals: Structure‐Based Design and Synthesis of Amino‐Phenoxazine β‐Hematin Inhibitors	103
Mass Spectrometric Assays Reveal Discrepancies in Inhibition Profiles for the SARS‐CoV‐2 Papain‐Like Protease	70
C9‐Functionalized Doxycycline Analogs as Drug Candidates to Prevent Pathological α‐Synuclein Aggregation and Neuroinflammation in Parkinson's Disease Degeneration	68
CYP3A4 Catalyzes the Rearrangement of the Dual Orexin Receptor Antagonist Daridorexant to 4‐Hydroxypiperidinol Metabolites	65
Covalent Fragment Screening Identifies Rgl2 RalGEF Cysteine for Targeted Covalent Inhibition of Ral GTPase Activation	59
Front Cover: Covalent Allosteric Inhibitors of Akt Generated Using a Click Fragment Approach (ChemMedChem 10/2022)	57
Chemical Design Strategy of Ionizable Lipids for In Vivo mRNA Delivery	55
Generation of Molecular Counterfactuals for Explainable Machine Learning Based on Core‐Substituent Recombination	49
Optimization of Ketobenzothiazole‐Based Type II Transmembrane Serine Protease Inhibitors to Block H1N1 Influenza Virus Replication	48
	46
Scouting Different Phosphodiesterase 4 Inhibitor Chemotypes in Silico To Guide the Design of Anti‐inflammatory/Antioxidant Agents	46
Anti‐Sporothrix Activity of Novel Copper‐Itraconazole Complexes	44
Late‐Stage Diversification of Pyrazoles as Antileishmanial Agents	44
Designing Cyclic Nitrogen‐Bridged Sulfonamides with Anti‐Cancer Activity	43
Insights into the Overcoming EGFR^{Del19/T790M/C797S} Mutation: A Perspective on the 2‐Aryl‐4‐aminothienopyrimidine Backbone	42
“Cofactors” for Natural Products	42
An Active Member of the EFMC: The Division of Medicinal Chemistry and Chemical Biology of the Swiss Chemical Society**	41
Incorporation of Trifluoromethyltriazoline in the Side Chain of 4‐Aminoquinolines: Synthesis and Evaluation as Antiplasmodial Agents	40
Front Cover: Design Principles for Balancing Lipophilicity and Permeability in beyond Rule of 5 Space (ChemMedChem 5/2024) (ChemMedChem 5/2024)	38
Front Cover: (ChemMedChem 12/2025)	37
Design and Synthesis of 1,3‐Diynes as Potent Antifungal Agents against Aspergillus fumigatus	34
Phosphate‐Containing Glycolipids: A Review on Synthesis and Bioactivity	33
Fluorescence‐Based Detection of Methionine for Noninvasive Cancer Diagnosis Using Cu–Sn Bimetallic Nanoclusters	30

Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4	29
	28
	26
Importance of Co‐operative Hydrogen Bonding in the Apramycin‐Ribosomal Decoding A‐Site Interaction	26
Nicorandil Repurposing in Orofacial Pain: Preclinical Findings in Adult Zebrafish	26
Hepatic‐Targeted Nano‐enzyme with Resveratrol Loading for Precise Relief of Nonalcoholic Steatohepatitis	26
API‐ILs Ionic Adducts: Solubility and Surface Activity Properties—En Route to New Paradigm in Drug Development	26
Fluorinated High‐Valent Sn(IV) Porphyrins Show Remarkable Photodynamic Activity in Cancer Cells	25
Excited State and Reactive Oxygen Species against Cancer and Pathogens: A Review on Sonodynamic and Sono‐Photodynamic Therapy	25
Advanced Hydrogels: Enhancing Tissue Bioengineering with RGD Peptides and Carbon Nanomaterials	25
Selenocarbamates As a Prodrug‐Based Approach to Carbonic Anhydrase Inhibition	24
Antimalarial and Anticancer Activity Evaluation of Bridged Ozonides, Aminoperoxides, and Tetraoxanes	24
Antiplasmodial and Antimalarial Activity of 3,5‐Diarylidenetetrahydro‐2H‐pyran‐4(3H)‐ones via Inhibition of Plasmodium falciparum Pyridoxal Synthase	24
Aspirin‐Conjugated Cholic Acid Derivative Combats Polymicrobial Infections and Inflammation	23
Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites	23
Nonsteroidal Anti‐Inflammatory Drugs as Modulators of Cation Channels: Fenamates Repurposing in Channelopathies	22
Development of C646‐Based Proteolysis Targeting Chimeras Degraders of the Lysine Acetyltransferases CBP and p300	22
E‐64c‐Hydrazide Based Cathepsin C Inhibitors: Optimizing the Interactions with the S1’‐S2’ Area	22
Investigating the C2 Modulation of the Imidazo[1,2‐a]pyrazine‐Based Hit Compound CTN1122: Synthesis, in vitro Antileishmanial Activity, Cytotoxicity and Casein Kinase 1 Inhibition	22
Synthesis of Fluorinated Imidazole[4,5f][1,10]phenanthroline Derivatives as Potential Inhibitors of Liver Cancer Cell Proliferation by Inducing Apoptosis via DNA Damage	22
Synthesis and Biological Evaluation of Dithiobisacetamides as Novel Urease Inhibitors	22
Neuroblastoma and its Target Therapies: A Medicinal Chemistry Review	21
Isoniazid‐Dihydropyrimidinone Molecular Hybrids: Design, Synthesis, Antitubercular Activity, and Cytotoxicity Investigations with Computational Validation	21
Selectfluor‐Mediated Chlorination and Fluorination of Arenes: Late‐Stage Functionalization of APIs and Its Biological Effects	21
	21
Exploiting the 5‐Amino‐11H‐Indolo[3,2‐c]isoquinoline Core to Achieve Better G‐Quadruplex Ligands for Cancer Therapy	21
Factors Affecting Liquid‐Liquid Phase Separation of RGG Peptides with DNA G‐Quadruplex	21
	20
Discovery of Truncated Cyclic Peptides Targeting an Induced‐Fit Pocket on PCSK9	20
Front Cover: Structure‐Activity Relationships, Tolerability and Efficacy of Microtubule‐Active 1,2,4‐Triazolo[1,5‐a]pyrimidines as Potential Candidates to Treat Human African Trypanosomiasis (C	20
Evaluation of a Radiolabeled Macrocyclic Peptide as Potential PET Imaging Probe for PD−L1	20
LIN28‐Targeting Chromenopyrazoles and Tetrahydroquinolines Induced Cellular Morphological Changes and Showed High Biosimilarity with BRD PROTACs	19
Intracellular Delivery of Antibodies for Selective Cell Signaling Interference	19
Ultrasound‐Assisted Synthesis of Pyrazoline Derivatives as Potential Antagonists of RAGE‐Mediated Pathologies: Insights from SAR Studies and Biological Evaluations	19
Mitochondria‐Targeting Metallodrugs for Cancer Therapy: Perspectives from Cell Death Modes	19
Front Cover: Cyclic Octapeptides Composed of Two Glutathione Units Outperform the Monomer in Lead Detoxification (ChemMedChem 15/2022)	18
Nucleoside Derivatives of 2,6‐Diaminopurine Antivirals: Base‐Modified Nucleosides with Broad‐Spectrum Antimicrobial Properties	18
Novel Quinazolinones Active against Multidrug‐Resistant Mycobacterium Tuberculosis: Synthesis, Antimicrobial Evaluation, and in Silico Exploration of Penicillin‐Binding Protein 1A as a Potentia	18
Asparagusic Acid – A Unique Approach toward Effective Cellular Uptake of Therapeutics: Application, Biological Targets, and Chemical Properties	18
Front Cover: A Promising Approach to Target Colorectal Cancer Using Hybrid Triarylmethanes (ChemMedChem 21/2024)	17
Isolation of a Natural Killer Group 2D Small‐Molecule Ligand from DNA‐Encoded Chemical Libraries	17
Benocyclidine (BTCP) as Non‐labelled Reporter Ligand for MS Binding Assays for the PCP Ion Channel Binding Site of the Desensitized Torpedo Nicotinic Acetylcholine Receptor (nAChR)	17
Front Cover: 3’‐Dehydroxypurpurogallin‐4‐Carboxamides as Influenza A Endonuclease Inhibitors: Synthesis, Structure‐Activity Relationship Analysis, and Structural Characterization of Protein Complex (C	17
Total Synthesis and Antibacterial Investigations of 1‐Hydroxyboivinianin A	17
Effective Anticancer Potential of a New Sulfonamide as a Carbonic Anhydrase IX Inhibitor Against Aggressive Tumors	16
Expanding the Repertoire of Low‐Molecular‐Weight Pentafluorosulfanyl‐Substituted Scaffolds	16
Development of Keap1‐Nrf2 Protein–Protein Interaction Inhibitor Activating Intracellular Nrf2 Based on the Naphthalene‐2‐acetamide Scaffold, and its Anti‐Inflammatory Effects	16
Andrographolide Derivatives Target the KEAP1/NRF2 Axis and Possess Potent Anti‐SARS‐CoV‐2 Activity	16
Design and Synthesis of Oligopeptidic Parvulin Inhibitors	16
Pantinin‐Derived Peptides against Veterinary Herpesviruses: Activity and Structural Characterization	16

Targeting Tetraspanins at Cell Interfaces: Functional Modulation and Exosome‐Based Drug Delivery for Precise Disease Treatment	16
Modifications to a Biphenolic Antibacterial Compound: Activity against ESKAPE Pathogens	15
Enhancing Stability and Entrapment Efficiency of Liposome‐Coated Mesoporous Silica Nanocarriers Using Polyoxyethylene Alkyl Ether as a Polyethylene Glycol Anchoring Agent	15
Recent Advances in Mitochondria‐Localized Luminescent Ruthenium(II) Metallodrugs as Anticancer Agents	15
Exploring Raloxifene‐Based Metallodrugs: A Versatile Vector Combined with Platinum(II), Palladium(II) and Nickel(II) Dichlorides and Carborates against Triple‐Negative Breast Cancer	15
Benzofuran and Benzo[b]thiophene‐2‐Carboxamide Derivatives as Modulators of Amyloid Beta (Aβ42) Aggregation	15
Progress of Mesoporous Silica Coated Gold Nanorods for Biological Imaging and Cancer Therapy	15
Coumarin‐Caged Nanoparticle for Light‐Driven Surface Modification	15
Corrigendum: Promising Therapeutic Approach for SARS‐CoV‐2 Infections by Using a Rutin‐Based Combination Therapy	15
	14
Chemo‐enzymatic Synthesis of Pseudo‐trisaccharide Aminoglycoside Antibiotics with Enhanced Nonsense Read‐through Inducer Activity	14
Front Cover: Interaction of a Jaundice Marker Molecule with a Redox‐Modulatory Nano‐Hybrid: A Combined Electrochemical and Spectroscopic Study toward the Development of a Theranostic Tool (ChemMedChem	14
2‐Difluoromethoxy‐Substituted Estratriene Sulfamates: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Steroid Sulfatase Inhibition	14
Inhibition of Human Cholinesterases and in vitro β‐Amyloid Aggregation by Rationally Designed Peptides	14
Improving the Photodynamic Activity of Water‐Soluble Porphyrin–Polysaccharide Complexes by Folic Acid Modification	14
Discovery of Novel Aminopyrimidines as Selective EP2 Receptor Antagonists	14
Front Cover: Synthesis of Unsymmetrical Squaramides as Allosteric GSK‐3β Inhibitors Promoting β‐Catenin‐Mediated Transcription of TCF/LEF in Retinal Pigment Epithelial Cells (ChemMedChem 24/2022)	14
Subnanomolar Cathepsin S Inhibitors with High Selectivity: Optimizing Covalent Reversible α‐Fluorovinylsulfones and α‐Sulfonates as Potential Immunomodulators in Cancer	14
Synthesis and in vitro Study of Artemisinin/Synthetic Peroxide‐Based Hybrid Compounds against SARS‐CoV‐2 and Cancer	14
Virtual Screening and Biological Evaluation of Natural Products as Novel VPS34 Inhibitors that Modulate Autophagy	13
Diversity Oriented Strategy (DOS) for the Efficient Synthesis of Benzofuro[2,3‐b]pyridine Derivatives with Anticancer Activity	13
Front Cover: Conception and Evaluation of Fluorescent Phosphine‐Gold Complexes: From Synthesis to in vivo Investigations (ChemMedChem 11/2022)	13
Acetic Acid‐Driven One‐Pot Synthesis of 4,7‐dihydro‐[1,2,3]thiadiazolo[5,4‐b]pyridine‐6‐carboxamides and Pharmacological Evaluations	13
Front Cover: Chemically Diverse S. mansoni HDAC8 Inhibitors Reduce Viability in Worm Larval and Adult Stages (ChemMedChem 3/2023)	13
	13
Deciphering the Binding Insights of Novel Disubstituted Anthraquinone Derivatives with G‐Quadruplex DNA to Exhibit Selective Cancer Cell Cytotoxicity	13
	13
Front Cover: Optimization of N‐Piperidinyl‐Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8‐Oxo‐Guanine DNA Glycosylase 1 (ChemMedChem 1/2023)	12
Potent Inhibition of Bacterial DNA Gyrase by Digallic Acid and Other Gallate Derivatives	12
Design and Synthesis of ⁶⁸Ga‐Labeled Peptide‐Based Heterodimers for Dual Targeting of NTS₁ and GRPR	12
Towards the Use of Metabolic Volatiles in Breath for Determining Drug Response: Gstachamine as an Unlabeled Substrate to Measure CYP3A4 Activity	12
Synthesis and Biological Evaluation of Cardiac Glycosides for Cancer Therapy by Targeting the DNA Damage Response	12
Carbon Dots as Bioactive Antifungal Nanomaterials	12
Ru‐Based Organometallic Agents Bearing Phenyl Hydroxide: Synthesis and Antibacterial Mechanism Study against Staphylococcus aureus	12
Screening and Synthesis of Tetrazole Derivatives that Inhibit the Growth of Cryptococcus Species	12
Design, Synthesis and Preliminary Bioactivity Evaluation of N‐Acetylcysteine Derivatives as Antioxidative and Anti‐Inflammatory Agents	12
The Therapeutic Potential in Cancer of Terpyridine‐Based Metal Complexes Featuring Group 11 Elements	12
Amphiphilic Fullerene‐BODIPY Photosensitizers for Targeted Photodynamic Therapy	12
Piperazine‐Modified Ketoconazole Derivatives Show Increased Activity against Fungal and Trypanosomatid Pathogens	12
Transition Metal Complexes with Tridentate Schiff Bases (O N O and O N N) Derived from Salicylaldehyde: An Analysis of Their Potential Anticancer Activity	11
In vivo Structure‐Activity Relationship of Dihydromethysticin in Reducing Nicotine‐Derived Nitrosamine Ketone (NNK)‐Induced Lung DNA Damage against Lung Carcinogenesis in A/J Mice	11
	11
Front Cover: Beyond the Toll‐Like Receptor 4. Structure‐Dependent Lipopolysaccharide Recognition Systems: How far are we? (ChemMedChem 6/2025)	11
Benzoxazoles Derived from Eugenol as Potential Agents against Arboviruses: Synthesis, Antiviral Studies, and Mechanistic Insights	11
Evaluating Bis‐Phenacyl Bromide‐Based Bis‐Heterocyclic Templates as Anticancer Prototypes and Potential PARP1 Inhibitors	11
Chemically Tuned Intracellular Gene Delivery by Core‐Shell Nanoparticles: Effects of Proton Buffering, Acid Degradability, and Membrane Disruption	11
Recent Progress in Prompt Molecular Detection of Exosomes Using CRISPR/Cas and Microfluidic‐Assisted Approaches Toward Smart Cancer Diagnosis and Analysis	11
Boosting the Impact of EFMC Young Scientists Network Through the Creation of Working Groups	11
Out of the Dark, into the Light: Metabolic Fluorescent Labeling of Nucleic Acids	11
Current Small Molecule–Based Medicinal Chemistry Approaches for Neurodegeneration Therapeutics	11
Synthesis and Structural Characterization of Macrocyclic Plasmin Inhibitors	11
Mitochondria‐Targeted Triphenylphosphonium Conjugated C‐3 Modified Betulin: Synthesis, Antitumor Properties and Mechanism of Action	11
Front Cover: Single Modification at the N‐Terminus of Norvancomycin to Combat Drug‐Resistant Gram‐Positive Bacteria (ChemMedChem 9/2023)	10
Corrigendum: Drug Repurposing for the SARS‐CoV‐2 Papain‐Like Protease	10
Membrane Proteins in Nanodiscs: Methods and Applications	10
	10
Design, Synthesis, and Biological Evaluation of Histone Deacetylase Inhibitors Derived from Erianin and Its Derivatives	10
Design, Synthesis, and Evaluation of Boron Dipyrromethene‐Based Fluorescent Probes Targeting BRAF for Melanoma Diagnosis	10
The French Medicinal Chemistry Society–SCT, an Historical Member of EFMC**	10
Structure‐Activity Studies Reveal Scope for Optimisation of Ebselen‐Type Inhibition of SARS‐CoV‐2 Main Protease	10
Synthesis and Characterization of a New Cationic Lipid: Efficient siRNA Delivery and Anticancer Activity of Survivin‐siRNA Lipoplexes for the Treatment of Lung and Breast Cancers**	10
Emerging Trends in Quinoxaline‐Based Analogs as Protein Kinase Inhibitors: Structural Developments and SAR Insights	10
Scaffold Hopping from Amodiaquine to Novel Nurr1 Agonist Chemotypes via Microscale Analogue Libraries	10
Front Cover: Structural Basis of Saccharin Derivative Inhibition of Carbonic Anhydrase IX (ChemMedChem 22/2023)	10
Spiro‐Acridine Compound as a Pteridine Reductase 1 Inhibitor: in silico Target Fishing and in vitro Studies	10
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Emerging Roles of Gossypol in Therapy: Innovations in Prodrug Design and Nanoformulation Frontiers	10
Phloroglucinol Derivatives Exert Anti‐Inflammatory Effects and Attenuate Cognitive Impairment in LPS‐Induced Mouse Model	10
Front Cover: When Two Become One: Conformational Changes in FXR/RXR Heterodimers Bound to Steroidal Antagonists (ChemMedChem 4/2023)	10
Design, Synthesis and Biological Evaluation of Ethyl 5‐(1‐benzyl‐1H‐indol‐5‐yl) Isoxazole‐3‐Carboxylates as Antimycobacterial Agents	10
Anti‐Carbonic Anhydrase Goldbodies by Conformational Reconstruction of the Complementary‐Determining Regions of Phage‐Displayed Antibodies	10
Corrigendum: Asparagusic Acid – A Unique Approach toward Effective Cellular Uptake of Therapeutics: Application, Biological Targets, and Chemical Properties	10
An Interdisciplinary Approach Provides Insights into the Pronounced Selectivity of Compound 42 for DPP9	10
Cyclic Octapeptides Composed of Two Glutathione Units Outperform the Monomer in Lead Detoxification	10
Front Cover: Total Synthesis of Antiausterity Agent Callistrilone O Reveals Promising Antitumor Activity in a Melanoma Homograft Mouse Model (ChemMedChem 7/2025)	9
Structure‐Activity Relationships of Flupirtine Analogues for Liver Esterase‐Mediated Cleavage of the 4‐Fluorobenzylamine Moiety and Its Possible Relevance to Liver Toxicity	9
Enhancing Targeted Drug Delivery through Cell‐Specific Endosomal Escape	9
Modification of Biphenolic Anti‐Bacterial to Achieve Broad‐Spectrum Activity	9
Adipocyte‐Targeted Nanotechnology and Cell‐Based Therapy for Obesity Treatment	9
The Chemerin Receptor CMKLR1 Requires Full‐Length Chemerin for High Affinity in Contrast to GPR1 as Demonstrated by a New Nanoluciferase‐Based Binding Assay	9

Machine Learning‐Driven QSAR Modeling of Anticancer Activity from a Rationally Designed Synthetic Flavone Library	9
Inflammaging and Immunosenescence in the Post‐COVID Era: Small Molecules, Big Challenges	9
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Machine Learning Guided Discovery of Non‐Hemolytic Membrane Disruptive Anticancer Peptides	9
Deriving Novel Quaternary Ammonium Compound Disinfectant Scaffolds from a Natural Product: Mechanistic Insights of the Quaternization of Ianthelliformisamine C	9
Identification of Balanol As a Potential Inhibitor of PAK1 That Induces Apoptosis and Cytoprotective Autophagy in Colorectal Cancer Cells	9
Cellular Effects of Cationic Copper(II) Schiff Base Complexes: Anti‐Inflammatory and Antiproliferative Properties	9
Design, Synthesis, and Xanthine Oxidase Inhibitory Activity of 4‐(5‐Aminosubstituted‐4‐cyanooxazol‐2‐yl)benzoic Acids	9
Prodrugs of E‐selectin Antagonists with Enhanced Pharmacokinetic Properties	9
Front Cover: Discovery of Benzo[d]imidazole‐6‐sulfonamides as Bromodomain and Extra‐Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain (ChemMedChem 20/2022)	9
Sulforaphane is Synergistic with CB‐5083 and Inhibits Colony Formation of CB‐5083‐Resistant HCT116 Cells	9
Investigation of Muscarinic Acetylcholine Receptor M₃ Activation in Atomistic Detail: A Chemist's Viewpoint	9
Histidinal‐Based Potent Antimalarial Agents	9
Cover Feature: How Should we Teach Medicinal Chemistry in Higher Education to Prepare Students for a Future Career as Medicinal Chemists and Drug Designers? – A Teacher's Perspective (ChemMedChem 2/20	9
Fluorinated Cycloalkyl Building Blocks for Drug Discovery	9
Harnessing Chemical Diversity to Disarm Bacterial Communication for 25 Years: Natural Products, Repurposed Drugs, Peptides, and Synthetic Quorum Sensing Inhibitors	9
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Peptide Assemblies for Cancer Therapy	9
Discovery and in vitro Evaluation of Novel Serotonin 5‐HT_2A Receptor Ligands Identified Through Virtual Screening	9
Unveiling Gelation and Antimicrobial Potentials of α‐Acyloxy Carboxamides: Findings from Experimental and Theoretical Approach	9
Spirooxindol‐1,3‐oxazine Alkaloids: Highly Potent and Selective Antitumor Agents Evolved from Iterative Structure Optimization	9
Zwitterionic Polymer: A New Paradigm for Protein Conjugation beyond PEG	9
Programmable Intelligent DNA Nanoreactors (iDNRs) for in vivo Tumor Diagnosis and Therapy	9
Structure and Dynamics of Monoclonal Antibody Domains Using Spins, Scattering, and Simulations	9
Front Cover: Efficient Synthesis of Benzothiazinone Analogues with Activity against Intracellular Mycobacterium tuberculosis (ChemMedChem 6/2022)	9
Opioid Ligands Addressing Unconventional Binding Sites and More Than One Opioid Receptor Subtype	9
Small Molecule‐Drug Conjugates: Opportunities for the Development of Targeted Anticancer Drugs	9
Front Cover: Incubation of Amyloidogenic Peptides in Reverse Micelles Allow Active Control of Oligomer Size and Study of Protein–Protein Interactions (ChemMedChem 23/2024)	9
Front Cover: Fragment‐Based Design, Synthesis, and Characterization of Aminoisoindole‐Derived Furin Inhibitors (ChemMedChem 9/2024)	8
Synthesis of a Gemcitabine Prodrug and its Encapsulation into Polymeric Nanoparticles for Improved Therapeutic Efficacy	8
Discovery of (2‐(4‐Substituted phenyl)quinolin‐4‐yl)(4‐isopropylpiperazin‐1‐yl)methanone Derivatives as Potent Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors	8
Identification of Potential Inhibitors of the SARS‐CoV‐2 NSP13 Helicase via Structure‐Based Ligand Design, Molecular Docking and Nonequilibrium Alchemical Simulations	8
Water‐Soluble Fullerene Monoderivatives for Biomedical Applications	8
Machine Learning‐Driven Discovery of Structurally Related Natural Products as Activators of the Cardiac Calcium Pump SERCA2a	8
N,N‐Diarylsulfonamide Reduces Proinflammatory Cytokine Interleukin‐6 Levels in Cells through Nuclear Factor‐κB Regulation	8
Recent Drug Development and Medicinal Chemistry Approaches for the Treatment of SARS‐CoV‐2 Infection and COVID‐19	8
Structural Development of Silicon‐Containing Retinoids: Structure–Activity Relationship Study of the Hydrophobic Pharmacophore of Retinobenzoic Acids Using Silyl Functionalities	8
Screening Methods for Cervical Cancer	8
Investigation of Novel Isatinylhydantoin Derivatives as Potential Anti‐Kinetoplastid Agents	8
Evaluation of Rhodanine Indolinones as AANAT Inhibitors	8
A Pleiotropic Nanomedicine Mitigates Splenic Hyperplasia, Ineffective Erythropoiesis, G6PDH Anomaly through Redox Buffering in Preclinical Mice Model	8
Hexafluoroisopropyl Carbamates as Selective MAGL and Dual MAGL/FAAH Inhibitors: Biochemical and Physicochemical Properties	8
1‐[2‐(1‐Cyclobutylpiperidin‐4‐yloxy)‐6,7‐dihydro‐4H‐thiazolo[5,4‐c]pyridin‐5‐yl]propan‐1‐one: a Histamine H₃ Receptor Inverse Agonist with Efficacy in Animal Models of Cogniti	8
Impact of Chelation on Reactivity and Cytotoxicity of Hemilabile Biphenyl Gold(III) N‐Heterocyclic Carbene Complexes	8
A Series of Thiadiazolyl‐Benzenesulfonamides Incorporating an Aromatic Tail as Isoform‐Selective, Potent Carbonic Anhydrase II/XII Inhibitors	8
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Chemical and Chemoenzymatic Synthesis of Peptide and Protein Therapeutics Conjugated with Human N‐Glycans	8
Exploring the Impact of C‐Terminal Based Pentapeptides on the Disassembly of Aβ₄₂ Fibrils	8
Beyond the Toll‐Like Receptor 4. Structure‐Dependent Lipopolysaccharide Recognition Systems: How far are we?	8
Front Cover: Complex pBAE Nanoparticle Cell Trafficking: Tracking Both Position and Composition Using Super Resolution Microscopy (ChemMedChem 13/2022)	8
Synthesis and Biological Characterization of 4,4‐Difluoro‐3‐(phenoxymethyl)piperidine Scaffold as Dopamine 4 Receptor (D₄R) Antagonist in vitro Tool compounds	8
Synthesis of 1,2,3‐Triazole‐Methyl‐Menadione Derivatives: Evaluation of Electrochemical and Antiparasitic Properties against two Blood‐Dwelling Parasites	8
Harnessing the Sulfur‐for‐Oxygen Shift: A Magic Bullet for Dynamic Photophysical and Anticancer Activities of Indole‐Barbituric Acid Construct	8
Inhibition Studies on Carbonic Anhydrase Isoforms I, II, IX, and XII with a Series of Sulfaguanidines	8
[1,2,4]Triazolo[1,5‐c]pyrimidines as Tools to Investigate A₃ Adenosine Receptors in Cancer Cell Lines	8
Front Cover: Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance (ChemMedChem 2/2023)	8
A Neutral and Stable Macrocyclic Mn(II) Complex for MRI Tumor Visualization	8
Rational Design of Novel Allosteric EYA2 Inhibitors as Potential Therapeutics for Multiple Brain Cancers	8
Proteolysis Targeting Chimeras (PROTACs) in Breast Cancer Therapy	8
Aminocholestane and Aminoandrostane Inhibitors of the SH2 Domain‐Containing Inositol 5’‐Phosphatase (SHIP)	8
How Should we Teach Medicinal Chemistry in Higher Education to Prepare Students for a Future Career as Medicinal Chemists and Drug Designers? – A Teacher's Perspective	8
Blood Components as Carriers for Small‐Molecule Platinum Anticancer Drugs	7
Copper‐Induced Supramolecular Assemblies for Biomedical Applications	7
Adenine Modification at C7 as a Viable Strategy to Potentiate the Antimalarial Activity of Quinolones	7
Anticancer Activity and Mechanism of Action Evaluation of an Acylhydrazone Cu(II) Complex toward Breast Cancer Cells, Spheroids, and Mammospheres	7
Carborane‐Based Tebufelone Analogs and Their Biological Evaluation In Vitro	7
Anticancer Activities of Tetrasubstituted Imidazole‐Pyrimidine‐Sulfonamide Hybrids as Inhibitors of EGFR Mutants	7
Design of Dual EP2/EP4 Antagonists through Scaffold Merging of Selective Inhibitors	7
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C7‐Halomethylene/methyl‐C3‐thiophenyl‐spirocyclic‐β‐lactams: Synthesis, X‐ray Analysis, Antimicrobial Evaluation, Cytotoxicity Profile and Molecular Docking Interactions	7
Mithplatins: Mithramycin SA‐Pt(II) Complex Conjugates for the Treatment of Platinum‐Resistant Ovarian Cancers	7
Elucidating the Unconventional Binding Mode of a DNA‐Encoded Library Hit Provides a Blueprint for Sirtuin 6 Inhibitor Development	7
Investigating the Role of Sulfate Groups for the Binding of Gd³⁺ Ions to Glycosaminoglycans with NMR Relaxometry	7
AMPK Activation by 2′‐Hydroxy‐2,4,5‐Trimethoxychalcone Derivatives in Podocyte Cells	7
Frontiers in Medicinal Chemistry 2022 Goes Virtual	7
The Hydrazine Moiety in the Synthesis of Modified Nucleosides and Nucleotides	7
Front Cover: Structure‐Based Drug Design of Novel Heterocyclic Scaffolds as TgCDPK1 Inhibitors (ChemMedChem 18/2025)	7
Promising Therapeutic Approach for SARS‐CoV‐2 Infections by Using a Rutin‐Based Combination Therapy	7
Sonodynamic Therapy with Metal Complexes: A New Promise in Cancer Therapy	7
New Indole‐Based Phenylthiazolyl‐2,4‐dihydropyrazolones as Tubulin polymerization inhibitors: Multicomponent Synthesis, Cytotoxicity Evaluation, and in silico Studies	7
Medicinal Chemistry for Practitioners. Edited by Jie Jack Li	7
Corrigendum: A Study of the Activity of Adamantyl Amines against Mutant Influenza A M2 Channels Identified a Polycyclic Cage Amine Triple Blocker, Explored by Molecular Dynamics Simulations and Solid‐	7
Cytotoxic, Antibacterial, and in Silico Pks13 Inhibitory Properties of Indole‐Coupled Dihydrobenzo[c]phenanthridines	7
Front Cover: (ChemMedChem 13/2025)	7
Ergosterol and Lanosterol Derivatives: Synthesis and Possible Biomedical Applications	7
Sulfonamide Bioisosteres of Niclosamide Enhance Antibacterial Activity of Colistin and Bacitracin	7
N‐Heterocyclic Carbene (NHC) Silver Complexes as Versatile Chemotherapeutic Agents Targeting Human Topoisomerases and Actin	7
Thiazole‐Based IL‐17 Inhibitors Discovered by Scaffold Morphing	7
Front Cover: The First Class of Small Molecules Potently Disrupting the YAP‐TEAD Interaction by Direct Competition (ChemMedChem 19/2022)	7
AgamOBP1‐Directed Discovery of Repellents to Control the Spread of Mosquito‐Borne Diseases	7
Front Cover: Bithiazole Inhibitors of Phosphatidylinositol 4‐Kinase (PI4KIIIβ) as Broad‐Spectrum Antivirals Blocking the Replication of SARS‐CoV‐2, Zika Virus, and Human Rhinoviruses (ChemMedChem 23/2	7
Exploring Derivatives of Quinolizidine Alkaloid Sophoridine in the Design and Biological Mechanistic Evaluation of Histone Deacetylase Inhibitors against Triple‐Negative Breast Cancer	7
Front Cover: [¹⁸F]NP3‐627, a Candidate PET Imaging Agent Targeting the NLRP3 Inflammasome in the Central Nervous System (ChemMedChem 4/2025)	7
3′‐Dehydroxypurpurogallin‐4‐Carboxamides as Influenza A Endonuclease Inhibitors: Synthesis, Structure–Activity Relationship Analysis, and Structural Characterization of Protein Complex	7
Silicon Phthalocyanines Functionalized with Axial Substituents Targeting PSMA: Synthesis and Preliminary Assessment of Their Potential for PhotoDynamic Therapy of Prostate Cancer	7