ChemMedChem

Article	Citations
Late‐Stage Diversification of Pyrazoles as Antileishmanial Agents	144
Substituted Benzylidene‐3‐Oxo‐3,4‐Dihydro‐2 H ‐Benzo[ b ][1,4]thiazine‐6‐Carboxylic Acid Analogs as Dynami	88
Generation of Molecular Counterfactuals for Explainable Machine Learning Based on Core‐Substituent Recombination	87
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Nicorandil Repurposing in Orofacial Pain: Preclinical Findings in Adult Zebrafish	77
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Front Cover: Design Principles for Balancing Lipophilicity and Permeability in beyond Rule of 5 Space (ChemMedChem 5/2024) (ChemMedChem 5/2024)	70
Scouting Different Phosphodiesterase 4 Inhibitor Chemotypes in Silico To Guide the Design of Anti‐inflammatory/Antioxidant Agents	62
Design and Synthesis of 1,3‐Diynes as Potent Antifungal Agents against Aspergillus fumigatus	58
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Anti‐Sporothrix Activity of Novel Copper‐Itraconazole Complexes	53
Front Cover: (ChemMedChem 12/2025)	51
Front Cover: Covalent Allosteric Inhibitors of Akt Generated Using a Click Fragment Approach (ChemMedChem 10/2022)	49
CYP3A4 Catalyzes the Rearrangement of the Dual Orexin Receptor Antagonist Daridorexant to 4‐Hydroxypiperidinol Metabolites	48
An Active Member of the EFMC: The Division of Medicinal Chemistry and Chemical Biology of the Swiss Chemical Society**	44
API‐ILs Ionic Adducts: Solubility and Surface Activity Properties—En Route to New Paradigm in Drug Development	41
Insights into the Overcoming EGFRDel19/T790M/C797S Mutation: A Perspective on the 2‐Aryl‐4‐aminothienopyrimidine Backbone	37
Designing Cyclic Nitrogen‐Bridged Sulfonamides with Anti‐Cancer Activity	36
Optimization of Ketobenzothiazole‐Based Type II Transmembrane Serine Protease Inhibitors to Block H1N1 Influenza Virus Replication	36
C9‐Functionalized Doxycycline Analogs as Drug Candidates to Prevent Pathological α‐Synuclein Aggregation and Neuroinflammation in Parkinson's Disease Degeneration	35
Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4	33
Phosphate‐Containing Glycolipids: A Review on Synthesis and Bioactivity	31
“Cofactors” for Natural Products	31
Fluorescence‐Based Detection of Methionine for Noninvasive Cancer Diagnosis Using Cu–Sn Bimetallic Nanoclusters	31
Cyclin‐Dependent Kinase 11: Cellular Functions and Potential Therapeutic Applications	30

Fluorinated High‐Valent Sn(IV) Porphyrins Show Remarkable Photodynamic Activity in Cancer Cells	29
Importance of Co‐operative Hydrogen Bonding in the Apramycin‐Ribosomal Decoding A‐Site Interaction	29
Quantum Osteoimmunology: A Paradigm Shift in Understanding and Influencing Bone–Immune Crosstalk	28
Front Cover: Functional Proteomics of Quinazolin‐4‐One Derivatives Targeting the Proteasome (ChemMedChem 2/2026)	28
Incorporation of Trifluoromethyltriazoline in the Side Chain of 4‐Aminoquinolines: Synthesis and Evaluation as Antiplasmodial Agents	28
Chemical Design Strategy of Ionizable Lipids for In Vivo mRNA Delivery	27
Hepatic‐Targeted Nano‐enzyme with Resveratrol Loading for Precise Relief of Nonalcoholic Steatohepatitis	27
The 5′ Cap Epitranscriptome and Beyond: Natural and Engineered 5′ Cap Modifications for Optimizing mRNA Therapeutics and Functional Studies	27
Metalloids: Semi as Metals yet Full of Antimicrobial Potential	27
Excited State and Reactive Oxygen Species against Cancer and Pathogens: A Review on Sonodynamic and Sono‐Photodynamic Therapy	26
Therapeutic Exosomes for Rare Cancers: Advances and Clinical Translation	26
Investigating the Ligand‐Binding Properties of N‐arylbenzimidazoles as Novel Elastase Inhibitors	25
Antiplasmodial and Antimalarial Activity of 3,5‐Diarylidenetetrahydro‐2H‐pyran‐4(3H)‐ones via Inhibition of Plasmodium falciparum Pyridoxal Synthase	25
Ultrasound‐Assisted Synthesis of Pyrazoline Derivatives as Potential Antagonists of RAGE‐Mediated Pathologies: Insights from SAR Studies and Biological Evaluations	25
Selectfluor‐Mediated Chlorination and Fluorination of Arenes: Late‐Stage Functionalization of APIs and Its Biological Effects	24
Discovery of Truncated Cyclic Peptides Targeting an Induced‐Fit Pocket on PCSK9	23
Antimalarial and Anticancer Activity Evaluation of Bridged Ozonides, Aminoperoxides, and Tetraoxanes	23
Nucleoside Derivatives of 2,6‐Diaminopurine Antivirals: Base‐Modified Nucleosides with Broad‐Spectrum Antimicrobial Properties	23
Modifications to a Biphenolic Antibacterial Compound: Activity against ESKAPE Pathogens	23
Development of New Benzo[ b ]Thiophene‐2‐Carboxamide Derivatives as Advanced Glycation End‐Products Receptor (RAGE) Antagonists	23
Benocyclidine (BTCP) as Non‐labelled Reporter Ligand for MS Binding Assays for the PCP Ion Channel Binding Site of the Desensitized Torpedo Nicotinic Acetylcholine Receptor (nAChR)	22
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Front Cover: 3’‐Dehydroxypurpurogallin‐4‐Carboxamides as Influenza A Endonuclease Inhibitors: Synthesis, Structure‐Activity Relationship Analysis, and Structural Characterization of Protein Complex (C	22
Front Cover: Structure‐Activity Relationships, Tolerability and Efficacy of Microtubule‐Active 1,2,4‐Triazolo[1,5‐a]pyrimidines as Potential Candidates to Treat Human African Trypanosomiasis (C	21
Front Cover: Cyclic Octapeptides Composed of Two Glutathione Units Outperform the Monomer in Lead Detoxification (ChemMedChem 15/2022)	20
Novel Quinazolinones Active against Multidrug‐Resistant Mycobacterium Tuberculosis: Synthesis, Antimicrobial Evaluation, and in Silico Exploration of Penicillin‐Binding Protein 1A as a Potentia	20
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Nonsteroidal Anti‐Inflammatory Drugs as Modulators of Cation Channels: Fenamates Repurposing in Channelopathies	19
Front Cover: A Promising Approach to Target Colorectal Cancer Using Hybrid Triarylmethanes (ChemMedChem 21/2024)	19
Total Synthesis and Antibacterial Investigations of 1‐Hydroxyboivinianin A	19
E‐64c‐Hydrazide Based Cathepsin C Inhibitors: Optimizing the Interactions with the S1’‐S2’ Area	18
Exploring Raloxifene‐Based Metallodrugs: A Versatile Vector Combined with Platinum(II), Palladium(II) and Nickel(II) Dichlorides and Carborates against Triple‐Negative Breast Cancer	18
Aspirin‐Conjugated Cholic Acid Derivative Combats Polymicrobial Infections and Inflammation	18
Neuroblastoma and its Target Therapies: A Medicinal Chemistry Review	18
Asparagusic Acid – A Unique Approach toward Effective Cellular Uptake of Therapeutics: Application, Biological Targets, and Chemical Properties	17
Mitochondria‐Targeting Metallodrugs for Cancer Therapy: Perspectives from Cell Death Modes	17
Nonstandard Factor VIIa Binding Mode Reveals S1 Pocket Plasticity in Trypsin‐Like Proteases	17
Exploiting the 5‐Amino‐11H‐Indolo[3,2‐c]isoquinoline Core to Achieve Better G‐Quadruplex Ligands for Cancer Therapy	17
Targeting Tetraspanins at Cell Interfaces: Functional Modulation and Exosome‐Based Drug Delivery for Precise Disease Treatment	17
Advanced Hydrogels: Enhancing Tissue Bioengineering with RGD Peptides and Carbon Nanomaterials	17
Isolation of a Natural Killer Group 2D Small‐Molecule Ligand from DNA‐Encoded Chemical Libraries	17
Pantinin‐Derived Peptides against Veterinary Herpesviruses: Activity and Structural Characterization	17
Development of Keap1‐Nrf2 Protein–Protein Interaction Inhibitor Activating Intracellular Nrf2 Based on the Naphthalene‐2‐acetamide Scaffold, and its Anti‐Inflammatory Effects	16
Effective Anticancer Potential of a New Sulfonamide as a Carbonic Anhydrase IX Inhibitor Against Aggressive Tumors	16
Factors Affecting Liquid‐Liquid Phase Separation of RGG Peptides with DNA G‐Quadruplex	16
Isoniazid‐Dihydropyrimidinone Molecular Hybrids: Design, Synthesis, Antitubercular Activity, and Cytotoxicity Investigations with Computational Validation	15
Structure‐ and Ligand‐Based Discovery of Novel 3‐Chymotrypsin‐Like Protease Nonpeptidomimetic Hits	15
LIN28‐Targeting Chromenopyrazoles and Tetrahydroquinolines Induced Cellular Morphological Changes and Showed High Biosimilarity with BRD PROTACs	15
Development of C646‐Based Proteolysis Targeting Chimeras Degraders of the Lysine Acetyltransferases CBP and p300	15
Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites	15

Self‐Immolative Systems in Diagnostic and Therapeutic Applications	15
Evaluation of Active and Passive Targeting Drug Delivery Systems as a Mechanism to Improve the Anticancer Potential of Titanium(IV)	15
Buckybowls at the Biointerface: Sumanene and Corannulene as Emerging Platforms for Medicinal Chemistry	14
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Design, Synthesis and Preliminary Bioactivity Evaluation of N‐Acetylcysteine Derivatives as Antioxidative and Anti‐Inflammatory Agents	14
Front Cover: Chemically Diverse S. mansoni HDAC8 Inhibitors Reduce Viability in Worm Larval and Adult Stages (ChemMedChem 3/2023)	14
Investigating the C2 Modulation of the Imidazo[1,2‐a]pyrazine‐Based Hit Compound CTN1122: Synthesis, in vitro Antileishmanial Activity, Cytotoxicity and Casein Kinase 1 Inhibition	14
Front Cover: Conception and Evaluation of Fluorescent Phosphine‐Gold Complexes: From Synthesis to in vivo Investigations (ChemMedChem 11/2022)	14
Small‐Molecule Inhibitors Targeting PD‐1/PD‐L1 in Colorectal Cancer: Mechanisms, Challenges, and Clinical Prospects	14
Towards the Use of Metabolic Volatiles in Breath for Determining Drug Response: Gstachamine as an Unlabeled Substrate to Measure CYP3A4 Activity	14
Front Cover: Interaction of a Jaundice Marker Molecule with a Redox‐Modulatory Nano‐Hybrid: A Combined Electrochemical and Spectroscopic Study toward the Development of a Theranostic Tool (ChemMedChem	14
In Silico‐Enabled Discovery and Development of Potent and Selective CDK11 Inhibitors	14
Benzofuran and Benzo[b]thiophene‐2‐Carboxamide Derivatives as Modulators of Amyloid Beta (Aβ42) Aggregation	13
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Ru‐Based Organometallic Agents Bearing Phenyl Hydroxide: Synthesis and Antibacterial Mechanism Study against Staphylococcus aureus	13
Improving the Photodynamic Activity of Water‐Soluble Porphyrin–Polysaccharide Complexes by Folic Acid Modification	13
Front Cover: Optimization of N‐Piperidinyl‐Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8‐Oxo‐Guanine DNA Glycosylase 1 (ChemMedChem 1/2023)	13
Screening and Synthesis of Tetrazole Derivatives that Inhibit the Growth of Cryptococcus Species	13
Coumarin‐Caged Nanoparticle for Light‐Driven Surface Modification	13
Corrigendum: Promising Therapeutic Approach for SARS‐CoV‐2 Infections by Using a Rutin‐Based Combination Therapy	13
Front Cover: Synthesis of Unsymmetrical Squaramides as Allosteric GSK‐3β Inhibitors Promoting β‐Catenin‐Mediated Transcription of TCF/LEF in Retinal Pigment Epithelial Cells (ChemMedChem 24/2022)	13
Virtual Screening and Biological Evaluation of Natural Products as Novel VPS34 Inhibitors that Modulate Autophagy	13
Deciphering the Binding Insights of Novel Disubstituted Anthraquinone Derivatives with G‐Quadruplex DNA to Exhibit Selective Cancer Cell Cytotoxicity	13
Discovery of Novel Aminopyrimidines as Selective EP2 Receptor Antagonists	12
Chemo‐enzymatic Synthesis of Pseudo‐trisaccharide Aminoglycoside Antibiotics with Enhanced Nonsense Read‐through Inducer Activity	12
Inhibition of Human Cholinesterases and in vitro β‐Amyloid Aggregation by Rationally Designed Peptides	12
Exploring Coumarin‐Triazole Derivatives as Selective Inhibitors of Carbonic Anhydrase IX and XII	12
Enhancing Stability and Entrapment Efficiency of Liposome‐Coated Mesoporous Silica Nanocarriers Using Polyoxyethylene Alkyl Ether as a Polyethylene Glycol Anchoring Agent	12
Diversity Oriented Strategy (DOS) for the Efficient Synthesis of Benzofuro[2,3‐b]pyridine Derivatives with Anticancer Activity	12
Discovery of Pyrazolo[5,1‐b]quinazoline Tethered 1,2,3‐Triazole Analogs as Potential Antioxidant Agents: Design, Synthesis, Biological Evaluation, and In Silico Insights	12
Design, Synthesis, and Biological Evaluation of Pseudo‐Natural Products Inspired by Aryloctahydroindole Alkaloids	12
Recent Advances in Mitochondria‐Localized Luminescent Ruthenium(II) Metallodrugs as Anticancer Agents	12
One‐Step Assembly of Homogeneous DAR4 ADCs via a Traceless Fc Ligand‐Directed Acylation Strategy	12
Acetic Acid‐Driven One‐Pot Synthesis of 4,7‐dihydro‐[1,2,3]thiadiazolo[5,4‐b]pyridine‐6‐carboxamides and Pharmacological Evaluations	12
Progress of Mesoporous Silica Coated Gold Nanorods for Biological Imaging and Cancer Therapy	12
Synthesis and Biological Evaluation of Cardiac Glycosides for Cancer Therapy by Targeting the DNA Damage Response	12
Design and Synthesis of 68Ga‐Labeled Peptide‐Based Heterodimers for Dual Targeting of NTS1 and GRPR	12
Piperazine‐Modified Ketoconazole Derivatives Show Increased Activity against Fungal and Trypanosomatid Pathogens	12
Front Cover: pH‐Responsive Isoprenoid‐Antitumoral Polymer Conjugates for Superior Drug Loading via Self‐Assembly and Endosomal‐Targeted Anticancer Activity (ChemMedChem 5/2026)	12
2‐Difluoromethoxy‐Substituted Estratriene Sulfamates: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Steroid Sulfatase Inhibition	12
Small‐Molecule Sarco/Endoplasmic Reticulum Ca 2+ ‐ATPase Activators Reverse Methylglyoxal‐Induced Inhibition through Nonantioxidant Mechanisms	12
Carbon Dots as Bioactive Antifungal Nanomaterials	11
Transition Metal Complexes with Tridentate Schiff Bases (O N O and O N N) Derived from Salicylaldehyde: An Analysis of Their Potential Anticancer Activity	11
Subnanomolar Cathepsin S Inhibitors with High Selectivity: Optimizing Covalent Reversible α‐Fluorovinylsulfones and α‐Sulfonates as Potential Immunomodulators in Cancer	11
Front Cover: Beyond the Toll‐Like Receptor 4. Structure‐Dependent Lipopolysaccharide Recognition Systems: How far are we? (ChemMedChem 6/2025)	11
Emerging Roles of Gossypol in Therapy: Innovations in Prodrug Design and Nanoformulation Frontiers	11
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Evaluating Bis‐Phenacyl Bromide‐Based Bis‐Heterocyclic Templates as Anticancer Prototypes and Potential PARP1 Inhibitors	11
Monodentate Phosphine Modulation in Cyclometallated Platinum(II) Complexes for Antileishmanial, Antiviral, and Antitumor Applications	11
An Interdisciplinary Approach Provides Insights into the Pronounced Selectivity of Compound 42 for DPP9	11
Benzoxazoles Derived from Eugenol as Potential Agents against Arboviruses: Synthesis, Antiviral Studies, and Mechanistic Insights	11
Membrane Proteins in Nanodiscs: Methods and Applications	11
Front Cover: Structural Basis of Saccharin Derivative Inhibition of Carbonic Anhydrase IX (ChemMedChem 22/2023)	11
Potent Inhibition of Bacterial DNA Gyrase by Digallic Acid and Other Gallate Derivatives	11
The Therapeutic Potential in Cancer of Terpyridine‐Based Metal Complexes Featuring Group 11 Elements	11
Breaking Down Barriers: CorA Effectively Targets Staphylococcal Biofilms in Vitro and in Vivo	11
Synthesis and Structural Characterization of Macrocyclic Plasmin Inhibitors	11
The French Medicinal Chemistry Society–SCT, an Historical Member of EFMC**	11
Front Cover: Single Modification at the N‐Terminus of Norvancomycin to Combat Drug‐Resistant Gram‐Positive Bacteria (ChemMedChem 9/2023)	11
Front Cover: When Two Become One: Conformational Changes in FXR/RXR Heterodimers Bound to Steroidal Antagonists (ChemMedChem 4/2023)	11
Synthesis and Characterization of a New Cationic Lipid: Efficient siRNA Delivery and Anticancer Activity of Survivin‐siRNA Lipoplexes for the Treatment of Lung and Breast Cancers**	10
Spiro‐Acridine Compound as a Pteridine Reductase 1 Inhibitor: in silico Target Fishing and in vitro Studies	10
Out of the Dark, into the Light: Metabolic Fluorescent Labeling of Nucleic Acids	10
Current Small Molecule–Based Medicinal Chemistry Approaches for Neurodegeneration Therapeutics	10
Emerging Trends in Quinoxaline‐Based Analogs as Protein Kinase Inhibitors: Structural Developments and SAR Insights	10
Cyclic Octapeptides Composed of Two Glutathione Units Outperform the Monomer in Lead Detoxification	10
Corrigendum: Asparagusic Acid – A Unique Approach toward Effective Cellular Uptake of Therapeutics: Application, Biological Targets, and Chemical Properties	10
Boosting the Impact of EFMC Young Scientists Network Through the Creation of Working Groups	10
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Recent Progress in Prompt Molecular Detection of Exosomes Using CRISPR/Cas and Microfluidic‐Assisted Approaches Toward Smart Cancer Diagnosis and Analysis	10
Phloroglucinol Derivatives Exert Anti‐Inflammatory Effects and Attenuate Cognitive Impairment in LPS‐Induced Mouse Model	10
Design and Synthesis of New Pyrazolo[1,5‐ c ]quinazolin‐5‐amines as Potential TLR7/8 Modulators	10
Tetrahydroindolone‐Dihydropyrimidinone Hybrids as Promising Antibiofilm and Antibacterial Agents	10
Design, Synthesis, and Evaluation of Boron Dipyrromethene‐Based Fluorescent Probes Targeting BRAF for Melanoma Diagnosis	10
Design, Synthesis, and Biological Evaluation of Histone Deacetylase Inhibitors Derived from Erianin and Its Derivatives	10
Anti‐Carbonic Anhydrase Goldbodies by Conformational Reconstruction of the Complementary‐Determining Regions of Phage‐Displayed Antibodies	10
Design, Synthesis and Biological Evaluation of Ethyl 5‐(1‐benzyl‐1H‐indol‐5‐yl) Isoxazole‐3‐Carboxylates as Antimycobacterial Agents	10
Front Cover: Incubation of Amyloidogenic Peptides in Reverse Micelles Allow Active Control of Oligomer Size and Study of Protein–Protein Interactions (ChemMedChem 23/2024)	9
Structure and Dynamics of Monoclonal Antibody Domains Using Spins, Scattering, and Simulations	9

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Deriving Novel Quaternary Ammonium Compound Disinfectant Scaffolds from a Natural Product: Mechanistic Insights of the Quaternization of Ianthelliformisamine C	9
Discovery and in vitro Evaluation of Novel Serotonin 5‐HT2A Receptor Ligands Identified Through Virtual Screening	9
Structure‐Activity Relationships of Flupirtine Analogues for Liver Esterase‐Mediated Cleavage of the 4‐Fluorobenzylamine Moiety and Its Possible Relevance to Liver Toxicity	9
Design, Synthesis, and Xanthine Oxidase Inhibitory Activity of 4‐(5‐Aminosubstituted‐4‐cyanooxazol‐2‐yl)benzoic Acids	9
Machine Learning‐Driven QSAR Modeling of Anticancer Activity from a Rationally Designed Synthetic Flavone Library	9
Spirooxindol‐1,3‐oxazine Alkaloids: Highly Potent and Selective Antitumor Agents Evolved from Iterative Structure Optimization	9
Front Cover: Polydopamine‐Based Light Responsive Nanoparticles with Magnetic Resonance Imaging Capabilities for Breast Cancer Photodynamic/Photothermal Therapy Combination Therapy (ChemMedChem 3/2026)	9
Design, Synthesis, and Biological Characterization of Macromolecular Ester Prodrugs of a Selective Cyclooxygenase‐2 Inhibitor	9
Front Cover: Total Synthesis of Antiausterity Agent Callistrilone O Reveals Promising Antitumor Activity in a Melanoma Homograft Mouse Model (ChemMedChem 7/2025)	9
Zwitterionic Polymer: A New Paradigm for Protein Conjugation beyond PEG	9
Peptide Assemblies for Cancer Therapy	9
Unveiling Gelation and Antimicrobial Potentials of α‐Acyloxy Carboxamides: Findings from Experimental and Theoretical Approach	9
Opioid Ligands Addressing Unconventional Binding Sites and More Than One Opioid Receptor Subtype	9
Front Cover: Discovery of Benzo[d]imidazole‐6‐sulfonamides as Bromodomain and Extra‐Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain (ChemMedChem 20/2022)	9
Investigation of Muscarinic Acetylcholine Receptor M3 Activation in Atomistic Detail: A Chemist's Viewpoint	9
Cover Feature: How Should we Teach Medicinal Chemistry in Higher Education to Prepare Students for a Future Career as Medicinal Chemists and Drug Designers? – A Teacher's Perspective (ChemMedChem 2/20	9
The Chemerin Receptor CMKLR1 Requires Full‐Length Chemerin for High Affinity in Contrast to GPR1 as Demonstrated by a New Nanoluciferase‐Based Binding Assay	9
Adipocyte‐Targeted Nanotechnology and Cell‐Based Therapy for Obesity Treatment	9
Targeting Cell division cycle 37: A Promising Novel Therapeutic Strategy	9
Identification of Balanol As a Potential Inhibitor of PAK1 That Induces Apoptosis and Cytoprotective Autophagy in Colorectal Cancer Cells	9
Histidinal‐Based Potent Antimalarial Agents	9
Machine Learning Guided Discovery of Non‐Hemolytic Membrane Disruptive Anticancer Peptides	9
Inflammaging and Immunosenescence in the Post‐COVID Era: Small Molecules, Big Challenges	9
Development of Styryl‐Modified 3,4‐Dihydropyrimidin‐2(1 H )‐ones as Potential Antitumor Agents	9
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Programmable Intelligent DNA Nanoreactors (iDNRs) for in vivo Tumor Diagnosis and Therapy	9
Enhancing Targeted Drug Delivery through Cell‐Specific Endosomal Escape	9
Harnessing Chemical Diversity to Disarm Bacterial Communication for 25 Years: Natural Products, Repurposed Drugs, Peptides, and Synthetic Quorum Sensing Inhibitors	9
Chemical and Chemoenzymatic Synthesis of Peptide and Protein Therapeutics Conjugated with Human N‐Glycans	8
Exploring the Impact of C‐Terminal Based Pentapeptides on the Disassembly of Aβ42 Fibrils	8
Screening Methods for Cervical Cancer	8
A Pleiotropic Nanomedicine Mitigates Splenic Hyperplasia, Ineffective Erythropoiesis, G6PDH Anomaly through Redox Buffering in Preclinical Mice Model	8
Investigation of Novel Isatinylhydantoin Derivatives as Potential Anti‐Kinetoplastid Agents	8
N,N‐Diarylsulfonamide Reduces Proinflammatory Cytokine Interleukin‐6 Levels in Cells through Nuclear Factor‐κB Regulation	8
Discovery of (2‐(4‐Substituted phenyl)quinolin‐4‐yl)(4‐isopropylpiperazin‐1‐yl)methanone Derivatives as Potent Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors	8
Fluorinated Cycloalkyl Building Blocks for Drug Discovery	8
Cytotoxicity and Antimicrobial Activity of GaMF1 Analogs	8
Identification of Potential Inhibitors of the SARS‐CoV‐2 NSP13 Helicase via Structure‐Based Ligand Design, Molecular Docking and Nonequilibrium Alchemical Simulations	8
How Should we Teach Medicinal Chemistry in Higher Education to Prepare Students for a Future Career as Medicinal Chemists and Drug Designers? – A Teacher's Perspective	8
Synthesis and Biological Characterization of 4,4‐Difluoro‐3‐(phenoxymethyl)piperidine Scaffold as Dopamine 4 Receptor (D 4 R) Antagonist in vitro Too	8
Glyoxalase‐1 Inhibition Leads to Ferroptosis Induction in Lung Cancer Cells: A Dual Mechanism of Action of Hydroxamic Acids Derived from Cysteine	8
Gram‐Scale Synthesis of an Arylsulfonamide‐Type Alkaline Phosphatase Inhibitor	8
Multidisciplinary Preclinical Investigations on Ferrocenyl, Ruthenocenyl, and Benzyl Derivatives of Niridazole as New Drug Candidates against Schistosomiasis	8
[1,2,4]Triazolo[1,5‐c]pyrimidines as Tools to Investigate A3 Adenosine Receptors in Cancer Cell Lines	8
Structural Development of Silicon‐Containing Retinoids: Structure–Activity Relationship Study of the Hydrophobic Pharmacophore of Retinobenzoic Acids Using Silyl Functionalities	8
Rational Design of Novel Allosteric EYA2 Inhibitors as Potential Therapeutics for Multiple Brain Cancers	8
Small Molecule‐Drug Conjugates: Opportunities for the Development of Targeted Anticancer Drugs	8
Aminocholestane and Aminoandrostane Inhibitors of the SH2 Domain‐Containing Inositol 5’‐Phosphatase (SHIP)	8
Decoding Class III Phosphatidylinositol 3‐Kinase (PtdIns3K) Regulation: Mechanistic Insights and Therapeutic Opportunities	8
Impact of Chelation on Reactivity and Cytotoxicity of Hemilabile Biphenyl Gold(III) N‐Heterocyclic Carbene Complexes	8
Recent Drug Development and Medicinal Chemistry Approaches for the Treatment of SARS‐CoV‐2 Infection and COVID‐19	8
Inhibition Studies on Carbonic Anhydrase Isoforms I, II, IX, and XII with a Series of Sulfaguanidines	8
Cellular Effects of Cationic Copper(II) Schiff Base Complexes: Anti‐Inflammatory and Antiproliferative Properties	8
Synthesis of 1,2,3‐Triazole‐Methyl‐Menadione Derivatives: Evaluation of Electrochemical and Antiparasitic Properties against two Blood‐Dwelling Parasites	8
Front Cover: Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance (ChemMedChem 2/2023)	8
Machine Learning‐Driven Discovery of Structurally Related Natural Products as Activators of the Cardiac Calcium Pump SERCA2a	8
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Front Cover: Complex pBAE Nanoparticle Cell Trafficking: Tracking Both Position and Composition Using Super Resolution Microscopy (ChemMedChem 13/2022)	8
A Neutral and Stable Macrocyclic Mn(II) Complex for MRI Tumor Visualization	8
Proteolysis Targeting Chimeras (PROTACs) in Breast Cancer Therapy	8
Harnessing the Sulfur‐for‐Oxygen Shift: A Magic Bullet for Dynamic Photophysical and Anticancer Activities of Indole‐Barbituric Acid Construct	8
Machine Learning‐Guided Repositioning of a SARS‐CoV‐2‐Targeting Molecular Series as Cruzain Inhibitors	8
Corrigendum: Discovery and Characterization of Multiple Classes of Human CatSper Blockers	7
Chimeric Amphiphilic Disinfectants: Quaternary Ammonium/Quaternary Phosphonium Hybrid Structures	7
Design of Dual EP2/EP4 Antagonists through Scaffold Merging of Selective Inhibitors	7
Synthesis of a Gemcitabine Prodrug and its Encapsulation into Polymeric Nanoparticles for Improved Therapeutic Efficacy	7
Boron Clusters Versus Adamantane: A Comparative Study of Inorganic and Organic Scaffolds Against Resistant Influenza A	7
Insights Into Vepdegestrant (ARV‐471): The First‐in‐Class Estrogen Receptor Proteolysis‐Targeting Chimera Approaching Food and Drug Administration Approval for Breast Cancer	7
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AMPK Activation by 2′‐Hydroxy‐2,4,5‐Trimethoxychalcone Derivatives in Podocyte Cells	7
Front Cover: Structure‐Based Drug Design of Novel Heterocyclic Scaffolds as TgCDPK1 Inhibitors (ChemMedChem 18/2025)	7
C7‐Halomethylene/methyl‐C3‐thiophenyl‐spirocyclic‐β‐lactams: Synthesis, X‐ray Analysis, Antimicrobial Evaluation, Cytotoxicity Profile and Molecular Docking Interactions	7
Design, Synthesis, and Biological Evaluation of Novel Triazine‐Based Dual Histone Deacetylase/phosphatidylinositol 3‐kinase Inhibitors for Breast Cancer Therapy	7
New Indole‐Based Phenylthiazolyl‐2,4‐dihydropyrazolones as Tubulin polymerization inhibitors: Multicomponent Synthesis, Cytotoxicity Evaluation, and in silico Studies	7
Quinic Acid and Synthetic Derivatives in Medicinal Chemistry	7
The Hydrazine Moiety in the Synthesis of Modified Nucleosides and Nucleotides	7
Beyond the Toll‐Like Receptor 4. Structure‐Dependent Lipopolysaccharide Recognition Systems: How far are we?	7
A Novel Tertiary Carbamate Prodrug Strategy to Overcome Metabolic Barriers in Oral Ketamine Delivery	7
Structure–Property Associations: Breaking Paradigms for Linking Chemical Structures and Biological Properties in Drug Discovery	7
Corrigendum: A Study of the Activity of Adamantyl Amines against Mutant Influenza A M2 Channels Identified a Polycyclic Cage Amine Triple Blocker, Explored by Molecular Dynamics Simulations and Solid‐	7
Frontiers in Medicinal Chemistry 2022 Goes Virtual	7
Developing Dynamic Structure‐Based Pharmacophore and ML‐Trained QSAR Models for the Discovery of Novel Resistance‐Free RET Tyrosine Kinase Inhibitors Through Extensive MD Trajectories and NRI Analysis	7
Blood Components as Carriers for Small‐Molecule Platinum Anticancer Drugs	7
Nature‐Inspired MYC Inhibitor Disrupts MYC‐Driven Glycolysis and Restricts Ovarian Tumor Growth	7
Synthesis, Characterization and in vitro Anticancer Evaluation of 5‐Sulfinyl(sulfonyl)‐4‐arylsulfonyl‐Substituted 1,3‐Oxazoles	7
Promising Therapeutic Approach for SARS‐CoV‐2 Infections by Using a Rutin‐Based Combination Therapy	7
Design and Synthesis of Novel 2‐Acetamido, 6‐Carboxamide Substituted Benzothiazoles as Potential BRAFV600E Inhibitors – In vitro Evaluation of their Antiproliferative Activity	7
A Novel Triose Phosphate Isomerase Inhibitor With Dual Trypanosomicidal Activity was Identified Using Artificial Intelligence‐Based Virtual Screening	7
Evaluation of Rhodanine Indolinones as AANAT Inhibitors	7
Chemical Derivatization Leads to the Discovery Of Novel Analogs of Azotochelin, a Natural Siderophore, as Promising Anticancer Agents	7
Front Cover: (ChemMedChem 13/2025)	7
Front Cover: The First Class of Small Molecules Potently Disrupting the YAP‐TEAD Interaction by Direct Competition (ChemMedChem 19/2022)	7
Antiproliferative Activity and Acute Toxicity of α,β‐Bis(diphenylphosphine Oxide)ethanes Obtained by Bisphosphorylation of Acetylenes: Electrosynthesis Under Mild Conditions Versus Improved Superbasic	7
Thiazole‐Based IL‐17 Inhibitors Discovered by Scaffold Morphing	7