ChemMedChem

Article	Citations
Drug Development and Medicinal Chemistry Efforts toward SARS‐Coronavirus and Covid‐19 Therapeutics	223
METTL3 Inhibitors for Epitranscriptomic Modulation of Cellular Processes	94
Therapeutic Strategies To Counteract Antibiotic Resistance in MRSA Biofilm‐Associated Infections	90
Antitumour Anthracyclines: Progress and Perspectives	90
A Quick Route to Multiple Highly Potent SARS‐CoV‐2 Main Protease Inhibitors**	88
Porphyrin‐Based Metal−Organic Framework Compounds as Promising Nanomedicines in Photodynamic Therapy	67
Cyclobutanes in Small‐Molecule Drug Candidates	64
Recent Development of Pyrimidine‐Containing Antimicrobial Agents	57
Pectin: A Long‐Neglected Broad‐Spectrum Antibacterial	56
Strategies To Design Selective Histone Deacetylase Inhibitors	56
The Critical Role of Passive Permeability in Designing Successful Drugs	54
Recent Advances in the Prediction of Pharmacokinetics Properties in Drug Design Studies: A Review	48
Recent Advances in Radiometals for Combined Imaging and Therapy in Cancer	47
2‐Isoxazolines: A Synthetic and Medicinal Overview	45
Cationic Amphiphilic Peptides: Synthetic Antimicrobial Agents Inspired by Nature	44
Benzimidazoles in Drug Discovery: A Patent Review	43
Copper: An Intracellular Achilles’ Heel Allowing the Targeting of Epigenetics, Kinase Pathways, and Cell Metabolism in Cancer Therapeutics	42
Coinage Metal N‐Heterocyclic Carbene Complexes: Recent Synthetic Strategies and Medicinal Applications	41
Cyclic Dipeptide: A Privileged Molecular Scaffold to Derive Structural Diversity and Functional Utility	37
A Patent Review on the Current Developments of Benzoxazoles in Drug Discovery	37
When Virtual Screening Yields Inactive Drugs: Dealing with False Theoretical Friends	37
E7766, a Macrocycle‐Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan‐Genotypic Activity	36
Malaria Pigment Crystals: The Achilles′ Heel of the Malaria Parasite	36
Piperazine, a Key Substructure for Antidepressants: Its Role in Developments and Structure‐Activity Relationships	35
MPI8 is Potent against SARS‐CoV‐2 by Inhibiting Dually and Selectively the SARS‐CoV‐2 Main Protease and the Host Cathepsin L**	35

Recent Drug Development and Medicinal Chemistry Approaches for the Treatment of SARS‐CoV‐2 Infection and COVID‐19	35
1,2,4‐Oxadiazole Topsentin Analogs with Antiproliferative Activity against Pancreatic Cancer Cells, Targeting GSK3β Kinase	32
Do Drug‐likeness Rules Apply to Oral Prodrugs?	32
Carbon Dots as Drug Delivery Vehicles for Antimicrobial Applications: A Minireview	32
Excited State and Reactive Oxygen Species against Cancer and Pathogens: A Review on Sonodynamic and Sono‐Photodynamic Therapy	32
Structure‐Activity Relationships of Benzamides and Isoindolines Designed as SARS‐CoV Protease Inhibitors Effective against SARS‐CoV‐2	32
Functional Nanomaterials in Biomedicine: Current Uses and Potential Applications	31
O‐GlcNAcase: Emerging Mechanism, Substrate Recognition and Small‐Molecule Inhibitors	31
New Antivirals and Antibacterials Based on Silver Nanoparticles	31
Gold(I) and Gold(III) N‐Heterocyclic Carbene Complexes as Antibacterial Agents and Inhibitors of Bacterial Thioredoxin Reductase	31
A Patent Review on FDA‐Approved Antibody‐Drug Conjugates, Their Linkers and Drug Payloads	30
ACE2, the Receptor that Enables Infection by SARS‐CoV‐2: Biochemistry, Structure, Allostery and Evaluation of the Potential Development of ACE2 Modulators	30
Fluorinated Cycloalkyl Building Blocks for Drug Discovery	29
Structure‐Based Macrocyclization of Substrate Analogue NS2B‐NS3 Protease Inhibitors of Zika, West Nile and Dengue viruses	29
The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia Disorders	28
Glycoconjugated Metal Complexes as Cancer Diagnostic and Therapeutic Agents	27
Alternating Cationic‐Hydrophobic Peptide/Peptoid Hybrids: Influence of Hydrophobicity on Antibacterial Activity and Cell Selectivity	26
A CaO2@Tannic Acid‐FeIII Nanoconjugate for Enhanced Chemodynamic Tumor Therapy	26
Mutual Prodrugs of 5‐Fluorouracil: From a Classic Chemotherapeutic Agent to Novel Potential Anticancer Drugs	26
Scanning Protein Surfaces with DNA‐Encoded Libraries	26
Emerging Nitric Oxide and Hydrogen Sulfide Releasing Carriers for Skin Wound Healing Therapy	26
An Organogold Compound as Potential Antimicrobial Agent against Drug‐Resistant Bacteria: Initial Mechanistic Insights	26
Drug Repurposing for the SARS‐CoV‐2 Papain‐Like Protease	26
Advances in Nucleoside and Nucleotide Analogues in Tackling Human Immunodeficiency Virus and Hepatitis Virus Infections	26
Synthesis of Tamoxifen‐Artemisinin and Estrogen‐Artemisinin Hybrids Highly Potent Against Breast and Prostate Cancer	25
Effect of Secondary Structure and Side Chain Length of Hydrophobic Amino Acid Residues on the Antimicrobial Activity and Toxicity of 14‐Residue‐Long de novo AMPs	25
BODIPY‐Based Photosensitizers as Potential Anticancer and Antibacterial Agents: Role of the Positive Charge and the Heavy Atom Effect	25
Mycobacterial Membrane Protein Large 3 (MmpL3) Inhibitors: A Promising Approach to Combat Tuberculosis	25
Comparing the Antileishmanial Activity of Gold(I) and Gold(III) Compounds in L. amazonensis and L. braziliensis in Vitro	25
The Role of Chronic Inflammation in Various Diseases and Anti‐inflammatory Therapies Containing Natural Products	25
Broad‐Spectrum Flavivirus Inhibitors: a Medicinal Chemistry Point of View	24
Explicit Treatment of Non‐Michaelis‐Menten and Atypical Kinetics in Early Drug Discovery**	24
Combining PARP Inhibition with Platinum, Ruthenium or Gold Complexes for Cancer Therapy	24
Prioritizing Small Sets of Molecules for Synthesis throughin‐silicoTools: A Comparison of Common Ranking Methods	23
Platinum Cyclooctadiene Complexes with Activity against Gram‐positive Bacteria	23
Acidity and Glutathione Dual‐Responsive Polydopamine‐Coated Organic‐Inorganic Hybrid Hollow Mesoporous Silica Nanoparticles for Controlled Drug Delivery	23
Autophagy‐Dependent Ferroptosis as a Therapeutic Target in Cancer	23
Recent Advances in the Discovery of Multitargeted Tyrosine Kinase Inhibitors as Anticancer Agents	23
The tale of proteolysis targeting chimeras (PROTACs) for Leucine‐Rich Repeat Kinase 2 (LRRK2)	23
Native Mass Spectrometry for the Study of PROTAC GNE‐987‐Containing Ternary Complexes	22
Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors	22
Helical Antimicrobial Peptide Foldamers Containing Non‐proteinogenic Amino Acids	22
Peptide‐Mimicking Poly(2‐oxazoline)s Displaying Potent Antimicrobial Properties	22
Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat	22
Amphiphilic Fullerene‐BODIPY Photosensitizers for Targeted Photodynamic Therapy	22
Synthesis and Biological Evaluation of Pyrazoline and Pyrrolidine‐2,5‐dione Hybrids as Potential Antitumor Agents	21
Design and Synthesis of DDR1 Inhibitors with a Desired Pharmacophore Using Deep Generative Models	21
A Patent Review on SARS Coronavirus Main Protease (3CLpro) Inhibitors	21
Pentathiepins: A Novel Class of Glutathione Peroxidase 1 Inhibitors that Induce Oxidative Stress, Loss of Mitochondrial Membrane Potential and Apoptosis in Human Cancer Cells	21
Advancements in the Development of Non‐Nitrogen‐Based Amphiphilic Antiseptics to Overcome Pathogenic Bacterial Resistance	21

Activatable NIR‐II Fluorescent Probes Applied in Biomedicine: Progress and Perspectives	21
Pt(IV) Anticancer Prodrugs – A Tale of Mice and Men	20
Synthesis of Dihydrobenzofuro[3,2‐b]chromenes as Potential 3CLpro Inhibitors of SARS‐CoV‐2: A Molecular Docking and Molecular Dynamics Study	20
First‐Generation Bispidine Chelators for 213BiIII Radiopharmaceutical Applications	20
Preparing (Metalla)carboranes for Nanomedicine	20
Application of Deep Neural Network Models in Drug Discovery Programs	20
Conjugated Polymers with Aggregation‐Induced Emission Characteristics for Fluorescence Imaging and Photodynamic Therapy	20
Evaluation of Water‐Soluble Mannich Base Prodrugs of 2,3,4,5‐Tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as Multitarget‐Directed Agents for Alzheimer's Disease	19
LYTACs: An Emerging Tool for the Degradation of Non‐Cytosolic Proteins	19
Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design	19
Recent Advances on Carbon Monoxide Releasing Molecules for Antibacterial Applications	19
An Advanced Apralog with Increased in vitro and in vivo Activity toward Gram‐negative Pathogens and Reduced ex vivo Cochleotoxicity	19
Surfing the Third Wave of Ionic Liquids: A Brief Review on the Role of Surface‐Active Ionic Liquids in Drug Development and Delivery	19
Amino Acid Based Antimicrobial Agents – Synthesis and Properties	19
Benzimidazole Derivatives as Novel Zika Virus Inhibitors	19
Iminodiacetic Acid as a Novel Metal‐Binding Pharmacophore for New Delhi Metallo‐β‐lactamase Inhibitor Development	18
Design, Synthesis, Structure‐Activity Relationship and Docking Studies of Novel Functionalized Arylvinyl‐1,2,4‐Trioxanes as Potent Antiplasmodial as well as Anticancer Agents	18
Theranostics Through the Synergistic Cooperation of Heterometallic Complexes	18
Synthesis and Antimicrobial Activity Evaluation of Imidazole‐Fused Imidazo[2,1‐b][1,3,4]thiadiazole Analogues	18
Synthesis and in vitro Study of Artemisinin/Synthetic Peroxide‐Based Hybrid Compounds against SARS‐CoV‐2 and Cancer	18
Peptidyl Vinyl Ketone Irreversible Inhibitors of Rhodesain: Modifications of the P2 Fragment	18
Spermine Derivatives of Indole‐3‐carboxylic Acid, Indole‐3‐acetic Acid and Indole‐3‐acrylic Acid as Gram‐Negative Antibiotic Adjuvants	18
Stimuli‐Responsive DNA Origami Nanodevices and Their Biological Applications	18
A Library of Thiazolidin‐4‐one Derivatives as Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitors: An Attempt To Discover Novel Antidiabetic Agents	18
Recent Advancement in the Search of Innovative Antiprotozoal Agents Targeting Trypanothione Metabolism	17
Gold Drugs with {Au(PPh3)}+ Moiety: Advantages and Medicinal Applications	17
Bioengineering of Anti‐Inflammatory Natural Products	17
Movement of Mitochondria with Mutant DNA through Extracellular Vesicles Helps Cancer Cells Acquire Chemoresistance	17
Synthesis and Biological Evaluation of CF3Se‐Substituted α‐Amino Acid Derivatives	17
Highly Phototoxic Transplatin‐Modified Distyryl‐BODIPY Photosensitizers for Photodynamic Therapy	17
Towards the Prediction of Antimicrobial Efficacy for Hydrogen Bonded, Self‐Associating Amphiphiles	17
Purinergic Signaling: Impact of GPCR Structures on Rational Drug Design	17
Aggregation‐Induced Emission Luminogens for Mitochondria‐Targeted Cancer Therapy	16
Recent Development of Copper (II) Complexes of Polypyridyl Ligands in Chemotherapy and Photodynamic Therapy	16
Small‐Molecule Inhibitors Targeting Sterol 14α‐Demethylase (CYP51): Synthesis, Molecular Modelling and Evaluation Against Candida albicans	16
Poly‐l‐lysine Glycoconjugates Inhibit DC‐SIGN‐mediated Attachment of Pandemic Viruses	16
Multitarget Inhibition of Histone Deacetylase (HDAC) and Phosphatidylinositol‐3‐kinase (PI3K): Current and Future Prospects	16
A “Golden Age” for the discovery of new antileishmanial agents: Current status of leishmanicidal gold complexes and prospective targets beyond the trypanothione system	16
Desorption Electrospray Ionization Mass Spectrometry Assay for Label‐Free Characterization of SULT2B1b Enzyme Kinetics	16
4‐Fluorobenzylpiperazine‐Containing Derivatives as Efficient Inhibitors of Mushroom Tyrosinase	16
Identification of the FDA‐Approved Drug Pyrvinium as a Small‐Molecule Inhibitor of the PD‐1/PD‐L1 Interaction	16
Transition Metal Complexes with Tridentate Schiff Bases (O N O and O N N) Derived from Salicylaldehyde: An Analysis of Their Potential Anticancer Activity	16
Synthesis and Structure−Activity Relationships of Imidazopyridine/Pyrimidine‐ and Furopyridine‐Based Anti‐infective Agents against Trypanosomiases	16
Amino Acid and Peptide‐Based Antiviral Agents	16
The First Class of Small Molecules Potently Disrupting the YAP‐TEAD Interaction by Direct Competition	16
Metal‐Based Catalytic Drug Development for Next‐Generation Cancer Therapy	16
Water‐Soluble Gold(III)–Metformin Complex Alters Mitochondrial Bioenergetics in Breast Cancer Cells	15
Short Photoswitchable Antibacterial Peptides	15
Mass Spectrometric Assays Reveal Discrepancies in Inhibition Profiles for the SARS‐CoV‐2 Papain‐Like Protease	15
Design, Synthesis, and Biological Evaluation of Lysine Demethylase 5 C Degraders	15
Oxygenating Biocatalysts for Hydroxyl Functionalisation in Drug Discovery and Development	15
A Novel Hybrid of Chloroquine and Primaquine Linked by Gold(I): Multitarget and Multiphase Antiplasmodial Agent	15
Mechanism toward Turn‐on of Polysaccharide‐Porphyrin Complexes for Fluorescence Probes and Photosensitizers in Photodynamic Therapy in Living Cells	15
Coumarin‐Thiourea Hybrids Show Potent Carbonic Anhydrase IX and XIII Inhibitory Action	15
New Pyrazine Conjugates: Synthesis, Computational Studies, and Antiviral Properties against SARS‐CoV‐2	15
Selective Fragments for the CREBBP Bromodomain Identified from an Encoded Self‐assembly Chemical Library	15
Thiazolidinediones: An In–Depth Study of Their Synthesis and Application to Medicinal Chemistry in the Treatment of Diabetes Mellitus	15
Contribution of Knoevenagel Condensation Products toward the Development of Anticancer Agents: An Updated Review	14
γ‐Non‐Symmetrically Dimasked TriPPPro Prodrugs as Potential Antiviral Agents against HIV	14
Functionalized Cannabinoid Subtype 2 Receptor Ligands: Fluorescent, PET, Photochromic and Covalent Molecular Probes	14
Controlling PROTACs with Light	14
New Platinum(II) Complexes Affecting Different Biomolecular Targets in Resistant Ovarian Carcinoma Cells	14
Aliphatic 18F‐Radiofluorination: Recent Advances in the Labeling of Base‐Sensitive Substrates**	14
Stimulation of Ca2+‐ATPase Transport Activity by a Small‐Molecule Drug	14
The Quest for Orally Available Selective Estrogen Receptor Degraders (SERDs)	14
Mechanistic Investigations of Metallo‐β‐lactamase Inhibitors: Strong Zinc Binding Is Not Required for Potent Enzyme Inhibition**	14
Structure‐Activity Relationships of Butyrophilin 3 Ligands	14
Prediction of Chameleonic Efficiency	13
Synthesis and Antimicrobial Evaluation of Bis‐morpholine Triazine Quaternary Ammonium Salts	13
Anticancer Activity of Mannich Bases: A Review of Recent Literature	13
Structure, Synthesis and Inhibition Mechanism of Nucleoside Analogues as HIV‐1 Reverse Transcriptase Inhibitors (NRTIs)	13
Styryl Group, a Friend or Foe in Medicinal Chemistry	13
Bithiazole Inhibitors of Phosphatidylinositol 4‐Kinase (PI4KIIIβ) as Broad‐Spectrum Antivirals Blocking the Replication of SARS‐CoV‐2, Zika Virus, and Human Rhinoviruses	13
Supramolecular Nanodrugs Based on Covalent Assembly of Therapeutic Peptides toward In Vitro Synergistic Anticancer Therapy	13
Structure‐Activity Studies Reveal Scope for Optimisation of Ebselen‐Type Inhibition of SARS‐CoV‐2 Main Protease	13
Two Methods, One Goal: Structural Differences between Cocrystallization and Crystal Soaking to Discover Ligand Binding Poses	13
Phosphonate as a Stable Zinc‐Binding Group for “Pathoblocker” Inhibitors of Clostridial Collagenase H (ColH)	13
Synthesis of Chimeric Thiazolo‐Nootkatone Derivatives as Potent Antimicrobial Agents	13
Next‐Generation Kinase Inhibitors Targeting Specific Biomarkers in Non‐Small Cell Lung Cancer (NSCLC): A Recent Overview	13
Discovery and Characterization of Multiple Classes of Human CatSper Blockers	13

Getting a Grip on the Undrugged: Targeting β‐Catenin with Fragment‐Based Methods	12
Selected 1,3‐Benzodioxine‐Containing Chalcones as Multipotent Oxidase and Acetylcholinesterase Inhibitors	12
Inspecting the Mechanism of Fragment Hits Binding on SARS‐CoV‐2 Mpro by Using Supervised Molecular Dynamics (SuMD) Simulations	12
Platinum(II) Complexes Bearing Triphenylphosphine and Chelating Oximes: Antiproliferative Effect and Biological Profile in Resistant Cells	12
Carborane‐Containing Matrix Metalloprotease (MMP) Ligands as Candidates for Boron Neutron‐Capture Therapy (BNCT)	12
Modelling and Phenotypic Screening of NAP‐6 and 10‐Cl‐BBQ, AhR Ligands Displaying Selective Breast Cancer Cytotoxicity in Vitro	12
Development of an Improved Guanidine‐Based Rac1 Inhibitor with in vivo Activity against Non‐Small Cell Lung Cancer	12
Small‐Molecule Inhibitors of Shp2 Phosphatase as Potential Chemotherapeutic Agents for Glioblastoma: A Minireview	12
Chemical and Structural Strategies to Selectively Target mTOR Kinase	12
Formaldehyde‐Crosslinked Nontoxic Aβ Monomers to Form Toxic Aβ Dimers and Aggregates: Pathogenicity and Therapeutic Perspectives	12
Experimental Methods for Evaluating the Bacterial Uptake of Trojan Horse Antibacterials	12
Effective Oral Administration of an Antitumorigenic Nanoformulated Titanium Complex	12
Antimalarial and Anticancer Activity Evaluation of Bridged Ozonides, Aminoperoxides, and Tetraoxanes	12
Anti‐Lung Cancer Activities of 1,2,3‐Triazole Curcumin Derivatives via Regulation of the MAPK/NF‐κB/STAT3 Signaling Pathways	12
Metal‐Based Aggregation‐Induced Emission Theranostic Systems	12
Turning Donepezil into a Multi‐Target‐Directed Ligand through a Merging Strategy	12
SAR Analysis of Heterocyclic Compounds with Monocyclic and Bicyclic Structures as Antifungal Agents	12
Red Emissive Carbon Dots Prepared from Polymers as an Efficient Nanocarrier for Coptisine Delivery in vivo and in vitro	12
Allosteric Molecular Switches in Metabotropic Glutamate Receptors	12
Ligand Accessibility Insights to the Dengue Virus NS3‐NS2B Protease Assessed by Long‐Timescale Molecular Dynamics Simulations	12
Stability and Cell Permeability of Sulfonyl Fluorides in the Design of Lys‐Covalent Antagonists of Protein‐Protein Interactions	12
Fragment‐Based Drug Discovery for RNA Targets	12
The European Federation for Medicinal Chemistry (EFMC) Best Practice Initiative: Validating Chemical Probes	11
Dual Parasiticidal Activities of Phthalimides: Synthesis and Biological Profile against Trypanosoma cruzi and Plasmodium falciparum	11
A Bimetallic Nanozyme with Cascade Effect for Synergistic Therapy of Cancer	11
A New Potent and Selective Monoamine Oxidase‐B Inhibitor with Extended Conjugation in a Chalcone Framework: 1‐[4‐(Morpholin‐4‐yl)phenyl]‐5‐phenylpenta‐2,4‐dien‐1‐one	11
A Potent Mimetic of the Siglec‐8 Ligand 6’‐Sulfo‐Sialyl Lewisx	11
Hybrid Quinazoline 1,3,5‐Triazines as Epidermal Growth Factor Receptor (EGFR) Inhibitors with Anticancer Activity: Design, Synthesis, and Computational Study	11
Conjugates of Tacrine with Salicylamide as Promising Multitarget Agents for Alzheimer's Disease	11
Expanding the Spectrum of Antibiotics Capable of Killing Multidrug‐Resistant Staphylococcus aureus and Pseudomonas aeruginosa	11
The Triazole Ring as a Privileged Scaffold for Putative Antifungals: Synthesis and Evaluation of a Series of New Analogues	11
Design, Synthesis, and Structure‐Activity Relationship Study of Pyrazolones as Potent Inhibitors of Pancreatic Lipase	11
Development of Novel Benzodiazepine‐Based Peptidomimetics as Inhibitors of Rhodesain from Trypanosoma brucei rhodesiense	11
Quinoline Hydrazide/Hydrazone Derivatives: Recent Insights on Antibacterial Activity and Mechanism of Action	11
Synthesis of Antiviral Perfluoroalkyl Derivatives of Teicoplanin and Vancomycin	11
A Dual Inhibitor of DYRK1A and GSK3β for β‐Cell Proliferation: Aminopyrazine Derivative GNF4877	11
Design, Synthesis, in vitro and in silico Characterization of 2‐Quinolone‐L‐alaninate‐1,2,3‐triazoles as Antimicrobial Agents	11
Anticancer Potential of Small‐Molecule Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase	11
7‐Amidocoumarins as Multitarget Agents against Neurodegenerative Diseases: Substitution Pattern Modulation	11
Design of Trehalose‐Based Amide/Sulfonamide C‐type Lectin Receptor Signaling Compounds	11
Clickable Selenylation – a Paradigm for Seleno‐Medicinal Chemistry	11
Machine Learning Guided Discovery of Non‐Hemolytic Membrane Disruptive Anticancer Peptides	11
Science's Response to CoVID‐19	11
Enhancement of CD8+ T‐Cell‐Mediated Tumor Immunotherapy via Magnetic Hyperthermia	11
Synthesis and Biological Evaluation of 10‐Substituted Camptothecin Derivatives with Improved Water Solubility and Activity	11
A Box of Chemistry to Inhibit the MEN1 Tumor Suppressor Gene Promoting Leukemia	11
Organofluorine Hydrazone Derivatives as Multifunctional Anti‐Alzheimer's Agents with CK2 Inhibitory and Antioxidant Features	11
The Structures of Gd(III) Chelates Conjugated at the Periphery of 3‐(1’‐Hexyloxy)ethyl‐3‐devinylpyropheophorbide‐a (HPPH) Have a Significant Impact on the Imaging and Therapy of Cancer	11
Synthesis, in vitro Antileishmanial Efficacy and Hit/Lead Identification of Nitrofurantoin‐Triazole Hybrids	11
A Computer‐Driven Scaffold‐Hopping Approach Generating New PTP1B Inhibitors from the Pyrrolo[1,2‐a]quinoxaline Core	10
Design and Synthesis of Fluorescent Methylphenidate Analogues for a FRET‐Based Assay of Synapsin III Binding	10
Microscale Parallel Synthesis of Acylated Aminotriazoles Enabling the Development of Factor XIIa and Thrombin Inhibitors	10
A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects	10
Increased in vitro Anti‐HIV Activity of Caffeinium‐Functionalized Polyoxometalates	10
Natural and Semisynthetic Pentacyclic Triterpenes for Chronic Myeloid Leukemia Therapy: Reality, Challenges and Perspectives	10
Evaluation of a Radiolabeled Macrocyclic Peptide as Potential PET Imaging Probe for PD−L1	10
A Green Synthesis of Carbene‐Metal‐Amides (CMAs) and Carboline‐Derived CMAs with Potentin vitroandex vivoAnticancer Activity	10
Recent Developments on the Synthesis and Biological Activities of Fused Pyrimidinone Derivatives	10
Liraglutide‐Loaded Milk Exosomes Lower Blood Glucose When Given by Sublingual Route	10
Anticancer Activity and Mechanism of Action Evaluation of an Acylhydrazone Cu(II) Complex toward Breast Cancer Cells, Spheroids, and Mammospheres	10
Praziquantel – 50 Years of Research	10
Virus‐Based Nanoreactors with GALT Activity for Classic Galactosemia Therapy	10
Activating Effect of 3‐Benzylidene Oxindoles on AMPK: From Computer Simulation to High‐Content Screening	10
Bicyclic Imidazolium Inhibitors of Gli Transcription Factor Activity	10
Strategies towards Targeting Gαi/s Proteins: Scanning of Protein‐Protein Interaction Sites To Overcome Inaccessibility	10
Using NMR Spectroscopy in the Fragment‐Based Drug Discovery of Small‐Molecule Anticancer Targeted Therapies	10
Aromatic Linkers Unleash the Antiproliferative Potential of 3‐Chloropiperidines Against Pancreatic Cancer Cells	10
25CN‐NBOH: A Selective Agonist for in vitro and in vivo Investigations of the Serotonin 2A Receptor	10
Development of LM98, a Small‐Molecule TEAD Inhibitor Derived from Flufenamic Acid	10
One‐Pot Synthesis and Antiproliferative Activity of Highly Functionalized Pyrazole Derivatives	10
Tricepyridinium‐inspired QACs yield potent antimicrobials and provide insight into QAC resistance	10
Efficient Synthesis of Benzothiazinone Analogues with Activity against Intracellular Mycobacterium tuberculosis	10
Into the Fray! A Beginner's Guide to Medicinal Chemistry	10
Point‐of‐Care Pathogen Detection with CRISPR‐based Programmable Nucleic Acid Binding Proteins	10
Design, Synthesis and Evaluation of a Series of 1,5‐Diaryl‐1,2,3‐triazole‐4‐carbohydrazones as Inhibitors of the YAP‐TAZ/TEAD Complex	10
Targeting the Water Network in Cyclin G‐Associated Kinase (GAK) with 4‐Anilino‐quin(az)oline Inhibitors	10
PROTAC Compatibilities, Degrading Cell‐Surface Receptors, and the Sticky Problem of Finding a Molecular Glue	10
Triazolyl‐Functionalized N‐Heterocyclic Carbene Half‐Sandwich Compounds: Coordination Mode, Reactivity and in vitro Anticancer Activity	10
Sulfonylguanidine Derivatives as Potential Antimelanoma Agents	10
Balancing Histone Deacetylase (HDAC) Inhibition and Drug‐likeness: Biological and Physicochemical Evaluation of Class I Selective HDAC Inhibitors	10
Physicochemical Properties of Zwitterionic Drugs in Therapy	10
Pentafluoro‐3‐hydroxy‐pent‐2‐en‐1‐ones Potently Inhibit FNT‐Type Lactate Transporters from all Five Human‐Pathogenic Plasmodium Species	10
β‐Actin Peptide‐Based Inhibitors of Histidine Methyltransferase SETD3	10
Self‐Assembled Porphyrinoids: One‐Component Nanostructured Photomedicines	10
6‐Methyl‐7‐Aryl‐7‐Deazapurine Nucleosides as Anti‐Trypanosoma cruzi Agents: Structure‐Activity Relationship and in vivo Efficacy	10
Vildagliptin‐Derived Dipeptidyl Peptidase 9 (DPP9) Inhibitors: Identification of a DPP8/9‐Specific Lead	9
The Stone Guest: How Does pH Affect Binding Properties of PD‐1/PD‐L1 Inhibitors?	9
Discovery of Isatin‐Based Carbohydrazones as Potential Dual Inhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase	9
Cell‐Penetrating Peptide‐Conjugated BF2‐Oxasmaragdyrins as NIRF Imaging and Photothermal Agents	9
Polysubstituted Pyrimidines as mPGES‐1 Inhibitors: Discovery of Potent Inhibitors of PGE2 Production with Strong Anti‐inflammatory Effects in Carrageenan‐Induced Rat Paw Edema	9
N‐Heterocyclic Carbene (NHC) Silver Complexes as Versatile Chemotherapeutic Agents Targeting Human Topoisomerases and Actin	9
Structure‐Activity Relationship and Mode‐Of‐Action Studies Highlight 1‐(4‐Biphenylylmethyl)‐1H‐imidazole‐Derived Small Molecules as Potent CYP121 Inhibitors	9
A Series of 2‐((1‐Phenyl‐1H‐imidazol‐5‐yl)methyl)‐1H‐indoles as Indoleamine 2,3‐Dioxygenase 1 (IDO1) Inhibitors	9
Benzimidazole and Benzoxazole Zinc Chelators as Inhibitors of Metallo‐β‐Lactamase NDM‐1	9
Activation of Sirtuin 2 Inhibitors Employing Photoswitchable Geometry and Aqueous Solubility	9