ChemMedChem

Article	Citations
Structure‐Activity Relationship and Mode‐Of‐Action Studies Highlight 1‐(4‐Biphenylylmethyl)‐1H‐imidazole‐Derived Small Molecules as Potent CYP121 Inhibitors	149
Hepatic‐Targeted Nano‐enzyme with Resveratrol Loading for Precise Relief of Nonalcoholic Steatohepatitis	132
Covalent Fragment Screening Identifies Rgl2 RalGEF Cysteine for Targeted Covalent Inhibition of Ral GTPase Activation	99
Halogen‐Dance‐Based Synthesis of Phosphonomethoxyethyl (PME) Substituted 2‐Aminothiazoles as Potent Inhibitors of Bacterial Adenylate Cyclases	66
Scouting Different Phosphodiesterase 4 Inhibitor Chemotypes in Silico To Guide the Design of Anti‐inflammatory/Antioxidant Agents	61
Incorporation of Trifluoromethyltriazoline in the Side Chain of 4‐Aminoquinolines: Synthesis and Evaluation as Antiplasmodial Agents	60
Importance of Co‐operative Hydrogen Bonding in the Apramycin‐Ribosomal Decoding A‐Site Interaction	59
An Active Member of the EFMC: The Division of Medicinal Chemistry and Chemical Biology of the Swiss Chemical Society**	55
Front Cover: Covalent Allosteric Inhibitors of Akt Generated Using a Click Fragment Approach (ChemMedChem 10/2022)	52
Phosphate‐Containing Glycolipids: A Review on Synthesis and Bioactivity	51
Anti‐Sporothrix Activity of Novel Copper‐Itraconazole Complexes	51
Adsorption to the Surface of Hemozoin Crystals: Structure‐Based Design and Synthesis of Amino‐Phenoxazine β‐Hematin Inhibitors	49
	47
Design and Synthesis of 1,3‐Diynes as Potent Antifungal Agents against Aspergillus fumigatus	46
	44
Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4	43
Nicorandil Repurposing in Orofacial Pain: Preclinical Findings in Adult Zebrafish	43
“Cofactors” for Natural Products	41
Fluorinated High‐Valent Sn(IV) Porphyrins Show Remarkable Photodynamic Activity in Cancer Cells	40
CYP3A4 Catalyzes the Rearrangement of the Dual Orexin Receptor Antagonist Daridorexant to 4‐Hydroxypiperidinol Metabolites	40
C9‐Functionalized Doxycycline Analogs as Drug Candidates to Prevent Pathological α‐Synuclein Aggregation and Neuroinflammation in Parkinson's Disease Degeneration	39
Front Cover: Design Principles for Balancing Lipophilicity and Permeability in beyond Rule of 5 Space (ChemMedChem 5/2024) (ChemMedChem 5/2024)	39
Late‐Stage Diversification of Pyrazoles as Antileishmanial Agents	38
Optimization of Ketobenzothiazole‐Based Type II Transmembrane Serine Protease Inhibitors to Block H1N1 Influenza Virus Replication	37
Insights into the Overcoming EGFRDel19/T790M/C797S Mutation: A Perspective on the 2‐Aryl‐4‐aminothienopyrimidine Backbone	37

Designing Cyclic Nitrogen‐Bridged Sulfonamides with Anti‐Cancer Activity	36
Fluorescence‐Based Detection of Methionine for Noninvasive Cancer Diagnosis Using Cu–Sn Bimetallic Nanoclusters	35
Mass Spectrometric Assays Reveal Discrepancies in Inhibition Profiles for the SARS‐CoV‐2 Papain‐Like Protease	35
Generation of Molecular Counterfactuals for Explainable Machine Learning Based on Core‐Substituent Recombination	33
Excited State and Reactive Oxygen Species against Cancer and Pathogens: A Review on Sonodynamic and Sono‐Photodynamic Therapy	32
Chemical Design Strategy of Ionizable Lipids for In Vivo mRNA Delivery	32
LIN28‐Targeting Chromenopyrazoles and Tetrahydroquinolines Induced Cellular Morphological Changes and Showed High Biosimilarity with BRD PROTACs	31
Novel quinazolinones active against multidrug‐resistant Mycobacterium tuberculosis: synthesis, antimicrobial evaluation and in silico exploration of PonA1 as a potential target	31
	31
Ultrasound‐Assisted Synthesis of Pyrazoline Derivatives as Potential Antagonists of RAGE‐Mediated Pathologies: Insights from SAR Studies and Biological Evaluations	31
Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites	30
Isoniazid‐Dihydropyrimidinone Molecular Hybrids: Design, Synthesis, Antitubercular Activity, and Cytotoxicity Investigations with Computational Validation	29
Investigating the C2 Modulation of the Imidazo[1,2‐a]pyrazine‐Based Hit Compound CTN1122: Synthesis, in vitro Antileishmanial Activity, Cytotoxicity and Casein Kinase 1 Inhibition	29
Development of C646‐Based Proteolysis Targeting Chimeras Degraders of the Lysine Acetyltransferases CBP and p300	28
Total Synthesis and Antibacterial Investigations of 1‐Hydroxyboivinianin A	27
Exploiting the 5‐Amino‐11H‐Indolo[3,2‐c]isoquinoline Core to Achieve Better G‐Quadruplex Ligands for Cancer Therapy	27
Factors Affecting Liquid‐Liquid Phase Separation of RGG Peptides with DNA G‐Quadruplex	26
Selenocarbamates As a Prodrug‐Based Approach to Carbonic Anhydrase Inhibition	26
A Novel Minor Groove Binder as a Potential Therapeutic Agent for Myotonic Dystrophy Type 1	25
E‐64c‐Hydrazide Based Cathepsin C Inhibitors: Optimizing the Interactions with the S1’‐S2’ Area	25
Benocyclidine (BTCP) as Non‐labelled Reporter Ligand for MS Binding Assays for the PCP Ion Channel Binding Site of the Desensitized Torpedo Nicotinic Acetylcholine Receptor (nAChR)	24
Evaluation of a Radiolabeled Macrocyclic Peptide as Potential PET Imaging Probe for PD−L1	24
Nucleoside Derivatives of 2,6‐Diaminopurine Antivirals: Base‐Modified Nucleosides with Broad‐Spectrum Antimicrobial Properties	24
Design and Synthesis of Oligopeptidic Parvulin Inhibitors	23
Synthesis and Biological Evaluation of Dithiobisacetamides as Novel Urease Inhibitors	23
Expanding the Repertoire of Low‐Molecular‐Weight Pentafluorosulfanyl‐Substituted Scaffolds	23
Synthesis of Fluorinated Imidazole[4,5f][1,10]phenanthroline Derivatives as Potential Inhibitors of Liver Cancer Cell Proliferation by Inducing Apoptosis via DNA Damage	22
Antiplasmodial and Antimalarial Activity of 3,5‐Diarylidenetetrahydro‐2H‐pyran‐4(3H)‐ones via Inhibition of Plasmodium falciparum Pyridoxal Synthase	22
Front Cover: Structure‐Activity‐Relationship‐Aided Design and Synthesis of xCT Antiporter Inhibitors (ChemMedChem 17/2021)	22
Front Cover: Cyclic Octapeptides Composed of Two Glutathione Units Outperform the Monomer in Lead Detoxification (ChemMedChem 15/2022)	22
Front Cover: 3’‐Dehydroxypurpurogallin‐4‐Carboxamides as Influenza A Endonuclease Inhibitors: Synthesis, Structure‐Activity Relationship Analysis, and Structural Characterization of Protein Complex (C	21
	21
Discovery of Truncated Cyclic Peptides Targeting an Induced‐Fit Pocket on PCSK9	21
Front Cover: A Promising Approach to Target Colorectal Cancer Using Hybrid Triarylmethanes (ChemMedChem 21/2024)	21
Modifications to a Biphenolic Antibacterial Compound: Activity against ESKAPE Pathogens	21
Isolation of a Natural Killer Group 2D Small‐Molecule Ligand from DNA‐Encoded Chemical Libraries	20
Andrographolide Derivatives Target the KEAP1/NRF2 Axis and Possess Potent Anti‐SARS‐CoV‐2 Activity	20
Neuroblastoma and its Target Therapies: A Medicinal Chemistry Review	20
Front Cover: Structure‐Activity Relationships, Tolerability and Efficacy of Microtubule‐Active 1,2,4‐Triazolo[1,5‐a]pyrimidines as Potential Candidates to Treat Human African Trypanosomiasis (C	20
Advanced Hydrogels: Enhancing Tissue Bioengineering with RGD Peptides and Carbon Nanomaterials	20
Exploring Raloxifene‐Based Metallodrugs: A Versatile Vector Combined with Platinum(II), Palladium(II) and Nickel(II) Dichlorides and Carborates against Triple‐Negative Breast Cancer	20
Targeting Tetraspanins at Cell Interfaces: Functional Modulation and Exosome‐Based Drug Delivery for Precise Disease Treatment	20
Mitochondria‐Targeting Metallodrugs for Cancer Therapy: Perspectives from Cell Death Modes	20
Effective Anticancer Potential of a New Sulfonamide as a Carbonic Anhydrase IX Inhibitor Against Aggressive Tumors	19
Antimalarial and Anticancer Activity Evaluation of Bridged Ozonides, Aminoperoxides, and Tetraoxanes	19
Intracellular Delivery of Antibodies for Selective Cell Signaling Interference	19
Asparagusic Acid – A Unique Approach toward Effective Cellular Uptake of Therapeutics: Application, Biological Targets, and Chemical Properties	19
Selectfluor‐Mediated Chlorination and Fluorination of Arenes: Late‐Stage Functionalization of APIs and Its Biological Effects	19
Ru‐Based Organometallic Agents Bearing Phenyl Hydroxide: Synthesis and Antibacterial Mechanism Study against Staphylococcus aureus	18
Discovery of Novel Aminopyrimidines as Selective EP2 Receptor Antagonists	18

2‐Difluoromethoxy‐Substituted Estratriene Sulfamates: Synthesis, Antiproliferative SAR, Antitubulin Activity, and Steroid Sulfatase Inhibition	18
Chemo‐enzymatic Synthesis of Pseudo‐trisaccharide Aminoglycoside Antibiotics with Enhanced Nonsense Read‐through Inducer Activity	18
Benzofuran and Benzo[b]thiophene‐2‐Carboxamide Derivatives as Modulators of Amyloid Beta (Aβ42) Aggregation	18
Front Cover: Conception and Evaluation of Fluorescent Phosphine‐Gold Complexes: From Synthesis to in vivo Investigations (ChemMedChem 11/2022)	17
Design, Synthesis and Preliminary Bioactivity Evaluation of N‐Acetylcysteine Derivatives as Antioxidative and Anti‐Inflammatory Agents	17
Synthesis and Biological Evaluation of Cardiac Glycosides for Cancer Therapy by Targeting the DNA Damage Response	17
Virtual Screening and Biological Evaluation of Natural Products as Novel VPS34 Inhibitors that Modulate Autophagy	17
Evaluating Bis‐phenacyl bromide‐based Bis‐heterocyclic templates as anticancer prototypes and potential PARP1 inhibitors	17
Progress of Mesoporous Silica Coated Gold Nanorods for Biological Imaging and Cancer Therapy	17
Front Cover: Optimization of N‐Piperidinyl‐Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8‐Oxo‐Guanine DNA Glycosylase 1 (ChemMedChem 1/2023)	16
FOXM1 Inhibitors as Potential Diagnostic Agents: First Generation of a PET Probe Targeting FOXM1 To Detect Triple‐Negative Breast Cancer in vitro and in vivo	16
Front Cover: Chemically Diverse S. mansoni HDAC8 Inhibitors Reduce Viability in Worm Larval and Adult Stages (ChemMedChem 3/2023)	16
Corrigendum: Promising Therapeutic Approach for SARS‐CoV‐2 Infections by Using a Rutin‐Based Combination Therapy	16
	15
Screening and Synthesis of Tetrazole Derivatives that Inhibit the Growth of Cryptococcus Species	15
Piperazine‐Modified Ketoconazole Derivatives Show Increased Activity against Fungal and Trypanosomatid Pathogens	15
Acetic Acid‐Driven One‐Pot Synthesis of 4,7‐dihydro‐[1,2,3]thiadiazolo[5,4‐b]pyridine‐6‐carboxamides and Pharmacological Evaluations	15
Front Cover: Interaction of a Jaundice Marker Molecule with a Redox‐Modulatory Nano‐Hybrid: A Combined Electrochemical and Spectroscopic Study toward the Development of a Theranostic Tool (ChemMedChem	15
Diversity Oriented Strategy (DOS) for the Efficient Synthesis of Benzofuro[2,3‐b]pyridine Derivatives with Anticancer Activity	15
	15
Improving the Photodynamic Activity of Water‐Soluble Porphyrin–Polysaccharide Complexes by Folic Acid Modification	15
Front Cover: Synthesis of Unsymmetrical Squaramides as Allosteric GSK‐3β Inhibitors Promoting β‐Catenin‐Mediated Transcription of TCF/LEF in Retinal Pigment Epithelial Cells (ChemMedChem 24/2022)	15
Inhibition of Human Cholinesterases and in vitro β‐Amyloid Aggregation by Rationally Designed Peptides	15
Subnanomolar Cathepsin S Inhibitors with High Selectivity: Optimizing Covalent Reversible α‐Fluorovinylsulfones and α‐Sulfonates as Potential Immunomodulators in Cancer	14
Amphiphilic Fullerene‐BODIPY Photosensitizers for Targeted Photodynamic Therapy	14
Carbon Dots as Bioactive Antifungal Nanomaterials	14
Corrigendum: Asparagusic Acid – A Unique Approach toward Effective Cellular Uptake of Therapeutics: Application, Biological Targets, and Chemical Properties	14
Recent Advances in Mitochondria‐Localized Luminescent Ruthenium(II) Metallodrugs as Anticancer Agents	14
Synthesis and in vitro Study of Artemisinin/Synthetic Peroxide‐Based Hybrid Compounds against SARS‐CoV‐2 and Cancer	14
Potent Inhibition of Bacterial DNA Gyrase by Digallic Acid and Other Gallate Derivatives	14
Transition Metal Complexes with Tridentate Schiff Bases (O N O and O N N) Derived from Salicylaldehyde: An Analysis of Their Potential Anticancer Activity	14
Design and Synthesis of 68Ga‐Labeled Peptide‐Based Heterodimers for Dual Targeting of NTS1 and GRPR	14
Deciphering the Binding Insights of Novel Disubstituted Anthraquinone Derivatives with G‐Quadruplex DNA to Exhibit Selective Cancer Cell Cytotoxicity	14
Aliphatic 18F‐Radiofluorination: Recent Advances in the Labeling of Base‐Sensitive Substrates**	14
The Therapeutic Potential in Cancer of Terpyridine‐Based Metal Complexes Featuring Group 11 Elements	14
Spiro‐Acridine Compound as a Pteridine Reductase 1 Inhibitor: in silico Target Fishing and in vitro Studies	14
	13
	13
Mitochondria‐Targeted Triphenylphosphonium Conjugated C‐3 Modified Betulin: Synthesis, Antitumor Properties and Mechanism of Action	13
Front Cover: Single Modification at the N‐Terminus of Norvancomycin to Combat Drug‐Resistant Gram‐Positive Bacteria (ChemMedChem 9/2023)	13
Out of the Dark, into the Light: Metabolic Fluorescent Labeling of Nucleic Acids	13
Synthesis and Biological Evaluation of Dantrolene‐Like Hydrazide and Hydrazone Analogues as Multitarget Agents for Neurodegenerative Diseases	13
Front Cover: When Two Become One: Conformational Changes in FXR/RXR Heterodimers Bound to Steroidal Antagonists (ChemMedChem 4/2023)	13
The French Medicinal Chemistry Society–SCT, an Historical Member of EFMC**	13
Science's Response to CoVID‐19	13
In vivo Structure‐Activity Relationship of Dihydromethysticin in Reducing Nicotine‐Derived Nitrosamine Ketone (NNK)‐Induced Lung DNA Damage against Lung Carcinogenesis in A/J Mice	13
Cyclic Octapeptides Composed of Two Glutathione Units Outperform the Monomer in Lead Detoxification	12
Boosting the Impact of EFMC Young Scientists Network Through the Creation of Working Groups	12
Front Cover: Beyond the Toll‐Like Receptor 4. Structure‐Dependent Lipopolysaccharide Recognition Systems: How far are we? (ChemMedChem 6/2025)	12
Poly‐l‐lysine Glycoconjugates Inhibit DC‐SIGN‐mediated Attachment of Pandemic Viruses	12
Corrigendum: Drug Repurposing for the SARS‐CoV‐2 Papain‐Like Protease	12
Anti‐Carbonic Anhydrase Goldbodies by Conformational Reconstruction of the Complementary‐Determining Regions of Phage‐Displayed Antibodies	12
Membrane Proteins in Nanodiscs: Methods and Applications	12
Design, Synthesis, and Evaluation of Boron Dipyrromethene‐Based Fluorescent Probes Targeting BRAF for Melanoma Diagnosis	12
Chemically Tuned Intracellular Gene Delivery by Core‐Shell Nanoparticles: Effects of Proton Buffering, Acid Degradability, and Membrane Disruption	12
Design, Synthesis and Biological Evaluation of Ethyl 5‐(1‐benzyl‐1H‐indol‐5‐yl) Isoxazole‐3‐Carboxylates as Antimycobacterial Agents	12
Emerging Trends in Quinoxaline‐Based Analogs as Protein Kinase Inhibitors: Structural Developments and SAR Insights	12
Identification of a Putative β‐Arrestin Superagonist of the Growth Hormone Secretagogue Receptor (GHSR)	12
New Pyrazine Conjugates: Synthesis, Computational Studies, and Antiviral Properties against SARS‐CoV‐2	12
Synthesis and Structural Characterization of Macrocyclic Plasmin Inhibitors	11
Front Cover: Structural Basis of Saccharin Derivative Inhibition of Carbonic Anhydrase IX (ChemMedChem 22/2023)	11
Design, Synthesis, and Biological Evaluation of Histone Deacetylase Inhibitors Derived from Erianin and Its Derivatives	11
Structure‐Activity Studies Reveal Scope for Optimisation of Ebselen‐Type Inhibition of SARS‐CoV‐2 Main Protease	11
Development of 7SK snRNA Mimics That Inhibit HIV Transcription	11
An Interdisciplinary Approach Provides Insights into the Pronounced Selectivity of Compound 42 for DPP9	11
Synthesis and Characterization of a New Cationic Lipid: Efficient siRNA Delivery and Anticancer Activity of Survivin‐siRNA Lipoplexes for the Treatment of Lung and Breast Cancers**	11
Emerging Roles of Gossypol in Therapy: Innovations in Prodrug Design and Nanoformulation Frontiers	11
Phloroglucinol Derivatives Exert Anti‐Inflammatory Effects and Attenuate Cognitive Impairment in LPS‐Induced Mouse Model	11
Current Small Molecule–Based Medicinal Chemistry Approaches for Neurodegeneration Therapeutics	11
Recent Progress in Prompt Molecular Detection of Exosomes Using CRISPR/Cas and Microfluidic‐Assisted Approaches Toward Smart Cancer Diagnosis and Analysis	11
Spirooxindol‐1,3‐oxazine Alkaloids: Highly Potent and Selective Antitumor Agents Evolved from Iterative Structure Optimization	10
Investigation of Muscarinic Acetylcholine Receptor M3 Activation in Atomistic Detail: A Chemist's Viewpoint	10
Prodrugs of E‐selectin Antagonists with Enhanced Pharmacokinetic Properties	10
Front Cover: Efficient Synthesis of Benzothiazinone Analogues with Activity against Intracellular Mycobacterium tuberculosis (ChemMedChem 6/2022)	10
Structure‐Activity Relationships of Flupirtine Analogues for Liver Esterase‐Mediated Cleavage of the 4‐Fluorobenzylamine Moiety and Its Possible Relevance to Liver Toxicity	10
Front Cover: Discovery of Benzo[d]imidazole‐6‐sulfonamides as Bromodomain and Extra‐Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain (ChemMedChem 20/2022)	10
A Bivalent Supramolecular GCP Ligand Enables Blocking of the Taspase1/Importin α Interaction	10
	10
Sulforaphane is Synergistic with CB‐5083 and Inhibits Colony Formation of CB‐5083‐Resistant HCT116 Cells	10
Opioid Ligands Addressing Unconventional Binding Sites and More Than One Opioid Receptor Subtype	10

Identification of Balanol As a Potential Inhibitor of PAK1 That Induces Apoptosis and Cytoprotective Autophagy in Colorectal Cancer Cells	10
Scaffold Hopping from Amodiaquine to Novel Nurr1 Agonist Chemotypes via Microscale Analogue Libraries	10
Front Cover: Synthesis and Antimicrobial Activity Evaluation of Imidazole‐Fused Imidazo[2,1‐b][1,3,4]thiadiazole Analogues (15/2021)	10
Modification of Biphenolic Anti‐Bacterial to Achieve Broad‐Spectrum Activity	10
Histidinal‐Based Potent Antimalarial Agents	10
The Chemerin Receptor CMKLR1 Requires Full‐Length Chemerin for High Affinity in Contrast to GPR1 as Demonstrated by a New Nanoluciferase‐Based Binding Assay	9
Design, Synthesis, and Xanthine Oxidase Inhibitory Activity of 4‐(5‐Aminosubstituted‐4‐cyanooxazol‐2‐yl)benzoic Acids	9
Structure and Dynamics of Monoclonal Antibody Domains Using Spins, Scattering, and Simulations	9
Inflammaging and Immunosenescence in the Post‐COVID Era: Small Molecules, Big Challenges	9
A Series of Thiadiazolyl‐Benzenesulfonamides Incorporating an Aromatic Tail as Isoform‐Selective, Potent Carbonic Anhydrase II/XII Inhibitors	9
Cover Feature: How Should we Teach Medicinal Chemistry in Higher Education to Prepare Students for a Future Career as Medicinal Chemists and Drug Designers? – A Teacher's Perspective (ChemMedChem 2/20	9
Front Cover: Complex pBAE Nanoparticle Cell Trafficking: Tracking Both Position and Composition Using Super Resolution Microscopy (ChemMedChem 13/2022)	9
Peptide Assemblies for Cancer Therapy	9
1‐[2‐(1‐Cyclobutylpiperidin‐4‐yloxy)‐6,7‐dihydro‐4H‐thiazolo[5,4‐c]pyridin‐5‐yl]propan‐1‐one: a Histamine H3 Receptor Inverse Agonist with Efficacy in Animal Models of Cogniti	9
Zwitterionic Polymer: A New Paradigm for Protein Conjugation beyond PEG	9
	9
Recent Advances on Carbon Monoxide Releasing Molecules for Antibacterial Applications	9
Deriving Novel Quaternary Ammonium Compound Disinfectant Scaffolds from a Natural Product: Mechanistic Insights of the Quaternization of Ianthelliformisamine C	9
Formaldehyde‐Crosslinked Nontoxic Aβ Monomers to Form Toxic Aβ Dimers and Aggregates: Pathogenicity and Therapeutic Perspectives	9
Unveiling Gelation and Antimicrobial Potentials of α‐Acyloxy Carboxamides: Findings from Experimental and Theoretical Approach	9
Adipocyte‐Targeted Nanotechnology and Cell‐Based Therapy for Obesity Treatment	9
Structural Development of Silicon‐Containing Retinoids: Structure–Activity Relationship Study of the Hydrophobic Pharmacophore of Retinobenzoic Acids Using Silyl Functionalities	9
Small Molecule‐Drug Conjugates: Opportunities for the Development of Targeted Anticancer Drugs	9
Discovery of (2‐(4‐Substituted phenyl)quinolin‐4‐yl)(4‐isopropylpiperazin‐1‐yl)methanone Derivatives as Potent Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors	9
A Pleiotropic Nanomedicine Mitigates Splenic Hyperplasia, Ineffective Erythropoiesis, G6PDH Anomaly through Redox Buffering in Preclinical Mice Model	9
A Computer‐Driven Scaffold‐Hopping Approach Generating New PTP1B Inhibitors from the Pyrrolo[1,2‐a]quinoxaline Core	9
Discovery and in vitro Evaluation of Novel Serotonin 5‐HT2A Receptor Ligands Identified Through Virtual Screening	9
Enhancing Targeted Drug Delivery through Cell‐Specific Endosomal Escape	9
Front Cover: Incubation of Amyloidogenic Peptides in Reverse Micelles Allow Active Control of Oligomer Size and Study of Protein–Protein Interactions (ChemMedChem 23/2024)	9
Machine Learning Guided Discovery of Non‐Hemolytic Membrane Disruptive Anticancer Peptides	9
Front Cover: Total Synthesis of Antiausterity Agent Callistrilone O Reveals Promising Antitumor Activity in a Melanoma Homograft Mouse Model (ChemMedChem 7/2025)	9
Front Cover: Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance (ChemMedChem 2/2023)	9
Programmable Intelligent DNA Nanoreactors (iDNRs) for in vivo Tumor Diagnosis and Therapy	9
	9
Machine Learning‐Driven QSAR Modeling of Anti‐Cancer Activity from a Rationally Designed Synthetic Flavone Library	9
Fluorinated Cycloalkyl Building Blocks for Drug Discovery	9
Aminocholestane and Aminoandrostane Inhibitors of the SH2 Domain‐Containing Inositol 5’‐Phosphatase (SHIP)	8
Harnessing the Sulfur‐for‐Oxygen Shift: A Magic Bullet for Dynamic Photophysical and Anticancer Activities of Indole‐Barbituric Acid Construct	8
Investigation of Novel Isatinylhydantoin Derivatives as Potential Anti‐Kinetoplastid Agents	8
Inhibition Studies on Carbonic Anhydrase Isoforms I, II, IX, and XII with a Series of Sulfaguanidines	8
Rational Design of Novel Allosteric EYA2 Inhibitors as Potential Therapeutics for Multiple Brain Cancers	8
Synthesis and biological characterization of 4,4‐difluoro‐3(phenoxymethyl)piperidine scaffold as dopamine 4 receptor (D4R) antagonist in vitro tool compounds	8
Machine Learning‐Driven Discovery of Structurally Related Natural Products as Activators of the Cardiac Calcium Pump SERCA2a	8
Water‐Soluble Fullerene Monoderivatives for Biomedical Applications	8
Identification of Potential Inhibitors of the SARS‐CoV‐2 NSP13 Helicase via Structure‐Based Ligand Design, Molecular Docking and Nonequilibrium Alchemical Simulations	8
Hexafluoroisopropyl Carbamates as Selective MAGL and Dual MAGL/FAAH Inhibitors: Biochemical and Physicochemical Properties	8
Cellular Effects of Cationic Copper(II) Schiff Base Complexes: Anti‐Inflammatory and Antiproliferative Properties	8
How Should we Teach Medicinal Chemistry in Higher Education to Prepare Students for a Future Career as Medicinal Chemists and Drug Designers? – A Teacher's Perspective	8
N,N‐Diarylsulfonamide Reduces Proinflammatory Cytokine Interleukin‐6 Levels in Cells through Nuclear Factor‐κB Regulation	8
Exploring the Impact of C‐Terminal Based Pentapeptides on the Disassembly of Aβ42 Fibrils	8
A Patent Review on the Current Developments of Benzoxazoles in Drug Discovery	8
Synthesis and Antimicrobial Evaluation of Bis‐morpholine Triazine Quaternary Ammonium Salts	8
[1,2,4]Triazolo[1,5‐c]pyrimidines as Tools to Investigate A3 Adenosine Receptors in Cancer Cell Lines	8
Proteolysis Targeting Chimeras (PROTACs) in Breast Cancer Therapy	8
Synthesis of a Gemcitabine Prodrug and its Encapsulation into Polymeric Nanoparticles for Improved Therapeutic Efficacy	8
Synthesis of 1,2,3‐Triazole‐Methyl‐Menadione Derivatives: Evaluation of Electrochemical and Antiparasitic Properties against two Blood‐Dwelling Parasites	8
A Neutral and Stable Macrocyclic Mn(II) Complex for MRI Tumor Visualization	8
Chemical and Chemoenzymatic Synthesis of Peptide and Protein Therapeutics Conjugated with Human N‐Glycans	8
Recent Drug Development and Medicinal Chemistry Approaches for the Treatment of SARS‐CoV‐2 Infection and COVID‐19	8
Screening Methods for Cervical Cancer	8
Impact of chelation on reactivity and cytotoxicity of hemilabile biphenyl gold(III) N‐heterocyclic carbene complexes	8
Beyond the Toll‐Like Receptor 4. Structure‐Dependent Lipopolysaccharide Recognition Systems: How far are we?	8
Design and Synthesis of Novel 2‐Acetamido, 6‐Carboxamide Substituted Benzothiazoles as Potential BRAFV600E Inhibitors – In vitro Evaluation of their Antiproliferative Activity	7
	7
Promising Antifungal and Antibacterial Agents Based on 5‐Aryl‐2,2′‐bipyridines and Their Heteroligand Salicylate Metal Complexes: Synthesis, Bioevaluation, Molecular Docking	7
	7
Front Cover: Development of Fluorophosphoramidate as a Biocompatibly Transformable Functional Group and its Application as a Phosphate Prodrug for Nucleoside Analogs (ChemMedChem 17/2022)	7
Medicinal Chemistry for Practitioners. Edited by Jie Jack Li	7
Synthesis, Characterization and in vitro Anticancer Evaluation of 5‐Sulfinyl(sulfonyl)‐4‐arylsulfonyl‐Substituted 1,3‐Oxazoles	7
Ideas Behind the Tryptophan‐Mediated Petasis Reaction (TMPR) Concept for Peptide Stapling	7
Evaluation of Rhodanine Indolinones as AANAT Inhibitors	7
Anticancer Activity and Mechanism of Action Evaluation of an Acylhydrazone Cu(II) Complex toward Breast Cancer Cells, Spheroids, and Mammospheres	7
Fragment‐Based Drug Discovery for RNA Targets	7
Front Cover: Fragment‐Based Design, Synthesis, and Characterization of Aminoisoindole‐Derived Furin Inhibitors (ChemMedChem 9/2024)	7
Chemical Derivatization Leads to the Discovery Of Novel Analogs of Azotochelin, a Natural Siderophore, as Promising Anticancer Agents	7
Corrigendum: Discovery and Characterization of Multiple Classes of Human CatSper Blockers	7
In vitro and Microbiological Assay of Functionalized Hybrid Nanomaterials To Validate Their Efficacy in Nanotheranostics: A Combined Spectroscopic and Computational Study	7
Promising Therapeutic Approach for SARS‐CoV‐2 Infections by Using a Rutin‐Based Combination Therapy	7
Discovery of Covalent Bruton's Tyrosine Kinase Inhibitors with Decreased CYP2C8 Inhibitory Activity	7
The Hydrazine Moiety in the Synthesis of Modified Nucleosides and Nucleotides	7
N‐Heterocyclic Carbene (NHC) Silver Complexes as Versatile Chemotherapeutic Agents Targeting Human Topoisomerases and Actin	7
C7‐Halomethylene/methyl‐C3‐thiophenyl‐spirocyclic‐β‐lactams: Synthesis, X‐ray Analysis, Antimicrobial Evaluation, Cytotoxicity Profile and Molecular Docking Interactions	7
Sulfonamide Bioisosteres of Niclosamide Enhance Antibacterial Activity of Colistin and Bacitracin	7
Sonodynamic Therapy with Metal Complexes: A New Promise in Cancer Therapy	7
Exploring Derivatives of Quinolizidine Alkaloid Sophoridine in the Design and Biological Mechanistic Evaluation of Histone Deacetylase Inhibitors against Triple‐Negative Breast Cancer	7
New Indole‐Based Phenylthiazolyl‐2,4‐dihydropyrazolones as Tubulin polymerization inhibitors: Multicomponent Synthesis, Cytotoxicity Evaluation, and in silico Studies	7
Front Cover: Development of Enterovirus Antiviral Agents That Target the Viral 2C Protein (ChemMedChem 10/2023)	7
Front Cover: Bithiazole Inhibitors of Phosphatidylinositol 4‐Kinase (PI4KIIIβ) as Broad‐Spectrum Antivirals Blocking the Replication of SARS‐CoV‐2, Zika Virus, and Human Rhinoviruses (ChemMedChem 23/2	7
Adenine Modification at C7 as a Viable Strategy to Potentiate the Antimalarial Activity of Quinolones	7
Anticancer Activities of Tetrasubstituted Imidazole‐Pyrimidine‐Sulfonamide Hybrids as Inhibitors of EGFR Mutants	7
Front Cover: [18F]NP3‐627, a Candidate PET Imaging Agent Targeting the NLRP3 Inflammasome in the Central Nervous System (ChemMedChem 4/2025)	7
Chimeric Amphiphilic Disinfectants: Quaternary Ammonium/Quaternary Phosphonium Hybrid Structures	7
Developing Dynamic Structure‐Based Pharmacophore and ML‐Trained QSAR Models for the Discovery of Novel Resistance‐Free RET Tyrosine Kinase Inhibitors Through Extensive MD Trajectories and NRI Analysis	7
1‐Indanone and 1,3‐indandione Derivatives as Ligands for Misfolded α‐Synuclein Aggregates	7
Design of Dual EP2/EP4 Antagonists through Scaffold Merging of Selective Inhibitors	7