OOIR: Observatory of International Research

Papers

(The TQCC of Altex-Alternatives to Animal Experimentation is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Probabilistic risk assessment – the keystone for the future of toxicology	28
NAM-supported read-across: From case studies to regulatory guidance in safety assessment	18
Guidance document on Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0)	14
Perspectives on the evaluation and adoption of complex in vitro models in drug development: Workshop with the FDA and the pharmaceutical industry (IQ MPS Affiliate)	13
Pyrogen testing revisited on occasion of the 25th anniversary of the whole blood monocyte activation test	13
Next-generation risk assessment of chemicals – Rolling out a human-centric testing strategy to drive 3R implementation: The RISK-HUNT3R project perspective	11
How a GIVIMP certification program can increase confidence in in vitro methods	10
The state of the scientific revolution in toxicology	9
Reply to comment “Animal welfare and ethics in the collection of fetal blood for the production of fetal bovine serum”	9
A strategy towards the generation of testable adverse outcome pathways for nanomaterials	9
Characteristics to consider when selecting a positive control material for an in vitro assay	8
Ready for regulatory use: NAMs and NGRA for chemical safety assurance	8
ToxAIcology - The evolving role of artificial intelligence in advancing toxicology and modernizing regulatory science	7
Evaluation of an in vitro three-dimensional HepaRG spheroid model for genotoxicity testing using the high-throughput CometChip platform	7
On the usefulness of animals as a model system (part I): Overview of criteria and focus on robustness	7
Continuing animal tests on cosmetic ingredients for REACH in the EU	7
Retrospective analysis of dermal absorption triple pack data	6
New approach methods supporting read-across: Two neurotoxicity AOP-based IATA case studies	6
A new approach methodology (NAM) for the prediction of (nor)ibogaine-induced cardiotoxicity in humans	6
Academic application of Good Cell Culture Practice for induced pluripotent stem cells	6
Implementing in vitro bioactivity data to modernize priority setting of chemical inventories	5
Replacing fetal bovine serum (FBS) in research and testing	5
Consensus statement from the European Network of 3R Centres (EU3Rnet)	5
Educational use of animals in Europe indicates a reluctance to implement alternatives	5
A call for a Human Exposome Project	5

Limitations of animal epilepsy research models: Can epileptic human tissue provide translational benefit?	5
Organoid intelligence (OI) – The ultimate functionality of a brain microphysiological system	5
COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease – 3rd CIAO AOP Design Workshop	5
Leveraging microphysiological systems to address challenges encountered during development of oligonucleotide therapeutics	5
A triangular approach for the validation of new approach methods for skin sensitization	5
On the usefulness of animals as a model system (part II): Considering benefits within distinct use domains	5
Predictive performance of next generation human physiologically based kinetic (PBK) model predictions based on in vitro and in silico input data	4
Report of the 1st and 2nd Mystery of Reactive Oxygen Species Conferences	4
A high-throughput and highly automated genotoxicity screening assay	4
U.S. Federal Agency interests and key considerations for new approach methodologies for nanomaterials	4
Proceedings of a workshop to address animal methods bias in scientific publishing	4
Using the monocyte activation test as a stand-alone release test for medical devices	4
Mind the gaps: Prioritizing activities to meet regulatory needs for acute systemic lethality	4
A cell-based alternative to the mouse potency assay for pharmaceutical type E botulinum antitoxins	4
The future of Parkinson’s disease research: A new paradigm of human-specific investigation is necessary… and possible	3
Improving the quality of toxicology and environmental health systematic reviews: What journal editors can do	3
Engagement of scientists with the public and policymakers to promote alternative methods	3
COVID-19 – prime time for microphysiological systems, as illustrated for the brain	3
Understanding COVID-19 through adverse outcome pathways – 2nd CIAO AOP Design Workshop	3
Amplifying the impact of kidney microphysiological systems: predicting renal drug clearance using mechanistic modelling based on reconstructed drug secretion	3
Animal welfare and ethics in the collection of fetal blood for the production of fetal bovine serum	3
Grouping of UVCB substances with dose-response transcriptomics data from human cell-based assays	3
A human iPSC-based in vitro neural network formation assay to investigate neurodevelopmental toxicity of pesticides	3
Development of a network of carcinogenicity adverse outcome pathways and its employment as an evidence framework for safety assessment	3
SpheraCosmolife: a new tool for the risk assessment of cosmetic products	3
A survey to assess animal methods bias in scientific publishing	2
Novel prediction models for genotoxicity based on biomarker genes in human HepaRGTM cells	2
A microfluidic thyroid-liver platform to assess chemical safety in humans	2
Exploration of the GARDskin applicability domain: Indirectly acting haptens, hydrophobic substances and UVCBs	2
Impact of in vitro experimental variation in kinetic parameters on physiologically based kinetic (PBK) model simulations	2
Acceptance criteria for new approach methods in toxicology and human health-relevant life science research – part I	2
Integrated skin sensitization assessment based on OECD methods (III): Adding human data to the assessment	2
Application of Immunocompetent Microphysiological Systems in Drug Development: Current Perspective and Recommendations	2
Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells	2
Integrated skin sensitization assessment based on OECD methods (II): Hazard and potency by combining kinetic peptide reactivity and the “2 out of 3” Defined Approach	2
Applications of microphysiological systems to disease models in the biopharmaceutical industry: Opportunities and challenges	2
Comparison of human recombinant protein coatings and fibroblast-ECM to Matrigel for induced pluripotent stem cell culture and renal podocyte differentiation	2
Dog as the experimental model: Laboratory uses of dogs in the United States	2
REACH out-numbered! The future of REACH and animal numbers	2
A rodent thyroid-liver chip to capture thyroid toxicity on organ functional level	2
An alternative in vivo model to evaluate pluripotency of patient-specific iPSCs	2
Animal metrics: Tracking contributions of new approach methods to reduced animal use	2
How to formulate hypotheses and IATA to support grouping and read-across of nanoforms	2
Applying evidence-based methods to the development and use of adverse outcome pathways	2
Comparing translational success rates across medical research fields - A combined analysis of literature and clinical trial data	2
Potential of concentration-response data to broaden regulatory application of in vitro test guidelines	2
Applying a next generation risk assessment framework for skin sensitisation to inconsistent new approach methodology information	2
Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks	2