Altex-Alternatives to Animal Experimentation

Papers
(The TQCC of Altex-Alternatives to Animal Experimentation is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)
ArticleCitations
Application of high-throughput transcriptomics for mechanism-based biological read-across of short-chain carboxylic acid analogues of valproic acid_suppl147
Qualitative and quantitative concentration-response modelling of gene co-expression networks to unlock hepatotoxic mechanisms for next generation chemical safety assessment23
Erratum to National Workshop on Alternatives to Higher Animals in Toxicology and Biomedical Science21
Human relevant frontiers in drug safety and efficacy21
Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare13
Determining a point of departure for skin sensitization potency and quantitative risk assessment of fragrance ingredients using the GARDskin dose-response assay_suppl19
AOPs to connect food additives’ effects on gut microbiota to health outcomes9
Evaluation of an in vitro three-dimensional HepaRG spheroid model for genotoxicity testing using the high-throughput CometChip platform_suppl8
Amplifying the impact of kidney microphysiological systems: predicting renal drug clearance using mechanistic modelling based on reconstructed drug secretion_suppl8
Beyond Animal Testing Index: Benchmarking tool for a world beyond animal testing_suppl37
Challenges integrating skin sensitization data for assessment of difficult to test substances_suppl7
Incorporating new approach methodologies into regulatory nonclinical pharmaceutical safety assessment_suppl7
Grouping of UVCB substances with dose-response transcriptomics data from human cell-based assays_suppl6
The use of categorical regression in evidence integration_suppl6
A proof-of-concept rat toxicity study highlights the potential utility and challenges of virtual control groups_suppl5
Have the non-technical summaries of animal experiments in Europe improved? An update5
Sensitivity analysis and quality indicators for an in vitro oral irritation assay5
Predictive performance of next generation human physiologically based kinetic (PBK) model predictions based on in vitro and in silico input data_suppl15
Data-driven derivation of an adverse outcome pathway linking vascular endothelial growth factor receptor (VEGFR), endocrine disruption, and atherosclerosis_suppl15
Integrated skin sensitization assessment based on OECD methods (II): Hazard and potency by combining kinetic peptide reactivity and the “2 out of 3” Defined Approach4
Replacement, reduction, refinement: 3 days for 3Rs4
Off to a good start? Review of the predictivity of reactivity methods modelling the molecular initiating event of skin sensitization_suppl24
COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease – 3rd CIAO AOP Design Workshop_suppl4
Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells_suppl24
Integrated skin sensitization assessment based on OECD methods (III): Adding human data to the assessment_suppl24
Risk-based prioritization of PFAS using phenotypic and transcriptomic data from human induced pluripotent stem cell-derived hepatocytes and cardiomyocytes_Suppl14
Microphysiological endothelial models to characterize subcutaneous drug absorption4
Alternative Methods in Science: Towards Fluidic Systems4
A survey to assess animal methods bias in scientific publishing_suppl34
Integrated skin sensitization assessment based on OECD methods (III): Adding human data to the assessment_suppl34
Linking nanomaterial-induced mitochondrial dysfunction to existing adverse outcome pathways for chemicals_suppl13
A microfluidic thyroid-liver platform to assess chemical safety in humans3
Comparison of pyrogen assays by testing products exhibiting low endotoxin recovery_suppl3
Protectiveness of NAM-based hazard assessment – which testing scope is required?3
Identifying candidate reference chemicals for in vitro testing of the retinoid pathway for predictive developmental toxicity_suppl3
Animal research ethics as interaction of research ethics, animal ethics, and (animal protection) law3
2
Validation of the monocyte activation test with three therapeutic monoclonal antibodies2
In vitro models of the canine digestive tract as an alternative to in vivo assays: Advances and current challenges2
How to formulate hypotheses and IATA to support grouping and read-across of nanoforms2
Novel prediction models for genotoxicity based on biomarker genes in human HepaRGTM cells2
Russell and Burch’s 3Rs then and now: The case of Switzerland2
A call for a Human Exposome Project2
Intestinal in vitro transport assay combined with physiologically based kinetic modeling as a tool to predict bile acid levels in vivo_suppl12
Application of high-throughput transcriptomics for mechanism-based biological read-across of short-chain carboxylic acid analogues of valproic acid_suppl22
Engagement of scientists with the public and policymakers to promote alternative methods2
Alternative methods go green! Green toxicology as a sustainable approach for assessing chemical safety and designing safer chemicals2
Report on 2021 International Workshop for Non-animal Approaches in the Food Sector (Japan): Current status and avenues for further research2
A novel coculture system for assessing respiratory sensitizing potential by IL-4 in T cells2
Characterization of the C17.2 cell line as testing system for endocrine disruption-induced developmental neurotoxicity_suppl2
Open-source human skin model with an in vivo-like barrier for drug testing2
Systematic analysis of read-across adaptations in testing proposal evaluations by the European Chemicals Agency_suppl52
Evaluation of 147 perfluoroalkyl substances for immunotoxic and other (patho)physiological activities through phenotypic screening of human primary cells_suppl12
Integrated skin sensitization assessment based on OECD methods (I): Deriving a point of departure for risk assessment_suppl12
Systematic analysis of read-across adaptations in testing proposal evaluations by the European Chemicals Agency2
Evaluation of an in vitro three-dimensional HepaRG spheroid model for genotoxicity testing using the high-throughput CometChip platform2
Pollutant exposure and myocardial injury: Protocol and progress report for a toxicological systematic mapping review_Supplement2
Transition to animal-free science: Phasing out animal experiments, phasing in innovation2
Comparative evaluation of rat and human in vitro assays for evaluation of thyroid toxicity_suppl12
Impact of gut permeability on estimation of oral bioavailability for chemicals in commerce and the environment_suppl12
The importance of variations in in vitro dosimetry to support risk assessment of inhaled toxicants_suppl31
Integrated skin sensitization assessment based on OECD methods (I): Deriving a point of departure for risk assessment_suppl41
Proceedings of a workshop to address animal methods bias in scientific publishing1
The validation of regulatory test methods – Conceptual, ethical, and philosophical foundations1
Development of a network of carcinogenicity adverse outcome pathways and its employment as an evidence framework for safety assessment1
A human iPSC-based in vitro neural network formation assay to investigate neurodevelopmental toxicity of pesticides_suppl11
VitroScreen Seminar - Substance-based medical device qualification and classification: Pre-clinical approaches to mechanism of action1
Novel prediction models for genotoxicity based on biomarker genes in human HepaRGTM cells_suppl21
Integrated skin sensitization assessment based on OECD methods (I): Deriving a point of departure for risk assessment1
Off to a good start? Review of the predictivity of reactivity methods modelling the molecular initiating event of skin sensitization1
Characterization and optimization of variability in a human colonic epithelium culture model1
Characterization of the C17.2 cell line as testing system for endocrine disruption-induced developmental neurotoxicity1
Lung tumor microphysiological system with 3D endothelium to evaluate modulators of T-cell migration1
Beyond Animal Testing Index: Benchmarking tool for a world beyond animal testing_suppl21
Proceedings of a workshop to address animal methods bias in scientific publishing_suppl1
No more secrets: Enhancing transparency in animal research1
Integrated skin sensitization assessment based on OECD methods (II): Hazard and potency by combining kinetic peptide reactivity and the “2 out of 3” Defined Approach_suppl21
The importance of variations in in vitro dosimetry to support risk assessment of inhaled toxicants_suppl21
Technical framework for enabling high-quality measurements in new approach methodologies (NAMs)1
Micro-replace systems1
Beyond pharmaceuticals: Fit-for-purpose new approach methodologies for environmental cardiotoxicity testing1
National workshop on alternatives to higher animals in toxicology and biomedical science1
Beyond Animal Testing Index: Benchmarking tool for a world beyond animal testing_suppl11
A survey to assess animal methods bias in scientific publishing_suppl51
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