OOIR: Observatory of International Research

Papers

(The median citation count of Clinical Epigenetics is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Integrative genomics analysis of nasal intestinal-type adenocarcinomas demonstrates the major role of CACNA1C and paves the way for a simple diagnostic tool in male woodworkers	163
Novel genetic variants of KHDC3L and other members of the subcortical maternal complex associated with Beckwith–Wiedemann syndrome or Pseudohypoparathyroidism 1B and multi-locus imprinting disturbance	130
Psychostimulant-induced aberrant DNA methylation in an in vitro model of human peripheral blood mononuclear cells	90
Technical considerations in PCR-based assay design for diagnostic DNA methylation cancer biomarkers	86
Longitudinal monitoring of cell-free DNA methylation in ALK-positive non-small cell lung cancer patients	69
Hi-C profiling of cancer spheroids identifies 3D-growth-specific chromatin interactions in breast cancer endocrine resistance	66
Novel epigenetic network biomarkers for early detection of esophageal cancer	66
Disrupted methylation patterns at birth persist in early childhood: a prospective cohort analysis	58
DNA methylation patterns associated with konzo in Sub-Saharan Africa	58
Multi-omic alterations of the SWI/SNF complex define a clinical subgroup in lung adenocarcinoma	55
An epigenome-wide study of DNA methylation profiles and lung function among American Indians in the Strong Heart Study	53
Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells	50
Cross talk between acetylation and methylation regulators reveals histone modifier expression patterns posing prognostic and therapeutic implications on patients with colon cancer	47
Epigenetic adaptations of the masticatory mucosa to periodontal inflammation	46
Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer	44
Aberrant epigenetic and transcriptional events associated with breast cancer risk	41
Genome-wide promoter methylation profiling in a cellular model of melanoma progression reveals markers of malignancy and metastasis that predict melanoma survival	39
Whole blood methylome-derived features to discriminate endocrine hypertension	38
Validating biomarkers and models for epigenetic inference of alcohol consumption from blood	37
Maternal epigenetic clocks measured during pregnancy do not predict gestational age at delivery or offspring birth outcomes: a replication study in metropolitan Cebu, Philippines	36
DNA methyltransferase inhibitors combination therapy for the treatment of solid tumor: mechanism and clinical application	36
Predicting disease-free survival in colorectal cancer by circulating tumor DNA methylation markers	35
Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy	35
First step towards a consensus strategy for multi-locus diagnostic testing of imprinting disorders	34
Epigenetics of single-site and multi-site atherosclerosis in African Americans from the Genetic Epidemiology Network of Arteriopathy (GENOA)	33

Epigenome-wide DNA methylation profiling of conditioned pain modulation in individuals with non-specific chronic low back pain	33
Liquid biopsies based on DNA methylation as biomarkers for the detection and prognosis of lung cancer	32
Epigenome-wide association studies: current knowledge, strategies and recommendations	32
Genome-wide distribution of histone trimethylation reveals a global impact of bisphenol A on telomeric binding proteins and histone acetyltransferase factors: a pilot study with human and in vitro dat	32
Fetal exposure to phthalates and bisphenols and DNA methylation at birth: the Generation R Study	31
Epigenome-wide contributions to individual differences in childhood phenotypes: a GREML approach	31
Plasma lipid profiles in early adulthood are associated with epigenetic aging in the Coronary Artery Risk Development in Young Adults (CARDIA) Study	31
Reproductive history and blood cell DNA methylation later in life: the Young Finns Study	30
Maternal–fetal stress and DNA methylation signatures in neonatal saliva: an epigenome-wide association study	28
Epigenome-wide association study of lung function in Latino children and youth with asthma	28
Evaluation of global and intragenic hypomethylation in colorectal adenomas improves patient stratification and colorectal cancer risk prediction	28
Epigenetic quantification of circulating immune cells in peripheral blood of triple-negative breast cancer patients	27
Differential DNA methylation and changing cell-type proportions as fibrotic stage progresses in NAFLD	27
Aberrant DNA hydroxymethylation reshapes transcription factor binding in myeloid neoplasms	27
The ENmix DNA methylation analysis pipeline for Illumina BeadChip and comparisons with seven other preprocessing pipelines	27
Dynamic patterns of blood lipids and DNA methylation in response to statin therapy	27
Altered DNA methylation in estrogen-responsive repetitive sequences of spermatozoa of infertile men with shortened anogenital distance	26
Association of nutritional glycaemic indices with global DNA methylation patterns: results from the Moli-sani cohort	26
Integrated 5-hydroxymethylcytosine and fragmentation signatures as enhanced biomarkers in lung cancer	25
OXTR DNA methylation differentiates men on the obesity spectrum with and without binge eating disorder	25
Epigenetics of early-life adversity in youth: cross-sectional and longitudinal associations	25
The emerging role of epigenetic regulation in the progression of silicosis	24
Identification of differentially methylated regions in rare diseases from a single-patient perspective	24
DNA methylation patterns at and beyond the histological margin of early-stage invasive lung adenocarcinoma radiologically manifested as pure ground-glass opacity	24
Bisulfite profiling of the MGMT promoter and comparison with routine testing in glioblastoma diagnostics	24
Epigenetics of type 2 diabetes and diabetes-related outcomes in the Strong Heart Study	24
Correction to: ZMYND10, an epigenetically regulated tumor suppressor, exerts tumor-suppressive functions via miR145-5p/NEDD9 axis in breast cancer	24
Pre-implantation alcohol exposure induces lasting sex-specific DNA methylation programming errors in the developing forebrain	23
Investigating pathological epigenetic aberrations by epi-proteomics	23
High performance methylated DNA markers for detection of colon adenocarcinoma	23
Why epigenetics is (not) a biosocial science and why that matters	23
Decreased mitochondrial D-loop region methylation mediates an increase in mitochondrial DNA copy number in CADASIL	23
Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: an EWAS in multi-ethnic Asian individuals	22
JIB-04, a histone demethylase Jumonji C domain inhibitor, regulates phenotypic switching of vascular smooth muscle cells	22
Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature	22
High-throughput and affordable genome-wide methylation profiling of circulating cell-free DNA by methylated DNA sequencing (MeD-seq) of LpnPI digested fragments	21
Lifetime exposure to smoking, epigenetic aging, and morbidity and mortality in older adults	21
Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder	21
A randomized, phase II trial of oral azacitidine (CC-486) in patients with resected pancreatic adenocarcinoma at high risk for recurrence	21
DNA 5-hydroxymethylcytosine in pediatric central nervous system tumors may impact tumor classification and is a positive prognostic marker	20
Distinguishable DNA methylation defines disease susceptibility influenced by race and ethnicity	20
Promoter methylation-mediated repression of UNC5 receptors and the associated clinical significance in human colorectal cancer	20
Translation of a tissue epigenetic signature to circulating free DNA suggests BCAT1 as a potential noninvasive diagnostic biomarker for lung cancer	20
Guidelines for pre-analytical conditions for assessing the methylation of circulating cell-free DNA	20
Accurate prediction of acute pancreatitis severity based on genome-wide cell free DNA methylation profiles	20
Serum level of total histone 3, H3K4me3, and H3K27ac after non-emergent cardiac surgery suggests the persistence of smoldering inflammation at 3 months in an adult population	19
Epigenetic targeting of the ACE2 and NRP1 viral receptors limits SARS-CoV-2 infectivity	19
Epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progression	19
Pembrolizumab plus azacitidine in patients with chemotherapy refractory metastatic colorectal cancer: a single-arm phase 2 trial and correlative biomarker analysis	19
Patients with PWS and related syndromes display differentially methylated regions involved in neurodevelopmental and nutritional trajectory	19

Integrated multi-omics analyses reveal that BCAM is associated with epigenetic modification and tumor microenvironment subtypes of clear cell renal cell carcinoma	19
Alterations of DNA methylation were associated with the rapid growth of cortisol-producing adrenocortical adenoma during pregnancy	19
SEEMLIS: a flexible semi-automated method for enrichment of methylated DNA from low-input samples	18
Diagnosis of pulmonary nodules by DNA methylation analysis in bronchoalveolar lavage fluids	18
Cell-free DNA 5-hydroxymethylcytosine profiles of long non-coding RNA genes enable early detection and progression monitoring of human cancers	18
Epigenetic tumor heterogeneity in the era of single-cell profiling with nanopore sequencing	18
DNA methylome profiling reveals epigenetic regulation of lipoprotein-associated phospholipase A2 in human vulnerable atherosclerotic plaque	17
DNA methylation-based profiling reveals distinct clusters with survival heterogeneity in high-grade serous ovarian cancer	17
SETD2-mediated epigenetic regulation of noncanonical Wnt5A during osteoclastogenesis	17
Androgen receptor reprogramming demarcates prognostic, context-dependent gene sets in primary and metastatic prostate cancer	17
Association of prenatal alcohol exposure with offspring DNA methylation in mammals: a systematic review of the evidence	16
Characterising sex differences of autosomal DNA methylation in whole blood using the Illumina EPIC array	16
The spectrum of tuberculosis described as differential DNA methylation patterns in alveolar macrophages and alveolar T cells	16
NAA60 (HAT4): the newly discovered bi-functional Golgi member of the acetyltransferase family	16
Integrated single-cell RNA-seq and DNA methylation reveal the effects of air pollution in patients with recurrent spontaneous abortion	16
Maintenance of methylation profile in imprinting control regions in human induced pluripotent stem cells	16
Cell-type heterogeneity: Why we should adjust for it in epigenome and biomarker studies	16
DNA methylation profiling identifies two distinct subgroups in breast cancers with low hormone receptor expression, mainly associated with HER2 amplification status	15
5-Hydroxymethylation alterations in cell-free DNA reflect molecular distinctions of diffuse large B cell lymphoma at different primary sites	15
The CpG island methylator phenotype increases the risk of high-grade squamous intraepithelial lesions and cervical cancer	15
Low reliability of DNA methylation across Illumina Infinium platforms in cord blood: implications for replication studies and meta-analyses of prenatal exposures	15
Chromatin accessibility analysis identifies GSTM1 as a prognostic marker in human glioblastoma patients	15
DNA methylation and aeroallergen sensitization: The chicken or the egg?	15
PRC2: an epigenetic multiprotein complex with a key role in the development of rhabdomyosarcoma carcinogenesis	15
Evaluation of cross-platform compatibility of a DNA methylation-based glucocorticoid response biomarker	15
Prenatal risk factors and neonatal DNA methylation in very preterm infants	15
A core of differentially methylated CpG loci in gMDSCs isolated from neonatal and adult sources	15
Betamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation	15
Gender-affirming hormone therapy induces specific DNA methylation changes in blood	14
Impact of vitamin C supplementation on placental DNA methylation changes related to maternal smoking: association with gene expression and respiratory outcomes	14
Effect of menopausal hormone therapy on methylation levels in early and late postmenopausal women	14
Differentially hypomethylated cell-free DNA and coronary collateral circulation	14
Persistent blood DNA methylation changes one year after SARS-CoV-2 infection	14
H3K36 trimethylation-mediated biological functions in cancer	14
Chromatin accessibility and transcriptome integrative analysis revealed AP-1-mediated genes potentially modulate histopathology features in psoriasis	14
DNA methylation mediates the association between breastfeeding and early-life growth trajectories	14
Immune profiles and DNA methylation alterations related with non-muscle-invasive bladder cancer outcomes	14
Shifts in the immunoepigenomic landscape of monocytes in response to a diabetes-specific social support intervention: a pilot study among Native Hawaiian adults with diabetes	13
Bariatric surgery-induced weight loss and associated genome-wide DNA-methylation alterations in obese individuals	13
Liquid biopsy, using a novel DNA methylation signature, distinguishes pancreatic adenocarcinoma from benign pancreatic disease	13
Association of peripheral blood DNA methylation level with Alzheimer’s disease progression	13
Correction: miR-29c plays a suppressive role in breast cancer by targeting the TIMP3/STAT1/FOXO1 pathway	13
LINE-1 hypomethylation is associated with poor outcomes in locoregionally advanced oropharyngeal cancer	13
A deep learning model for early risk prediction of heart failure with preserved ejection fraction by DNA methylation profiles combined with clinical features	13
Detection of ovarian cancer using plasma cell-free DNA methylomes	13
Comparative analysis of the DNA methylation landscape in CD4, CD8, and B memory lineages	13
Correction to: Evaluation of global and intragenic hypomethylation in colorectal adenomas improves patient stratification and colorectal cancer risk prediction	13
Identification of DNA methylation biomarkers with potential to predict response to neoadjuvant chemotherapy in triple-negative breast cancer	13
Novel blood-based FUT7 DNA methylation is associated with lung cancer: especially for lung squamous cell carcinoma	13
Characterisation of ethnic differences in DNA methylation between UK-resident South Asians and Europeans	13
Gestational age acceleration is associated with epigenetic biomarkers of prenatal physiologic stress exposure	12
Relative contributions of six lifestyle- and health-related exposures to epigenetic aging: the Coronary Artery Risk Development in Young Adults (CARDIA) Study	12
Regulation of oxytocin receptor gene expression in obsessive–compulsive disorder: a possible role for the microbiota-host epigenetic axis	12
Cardiovascular health and four epigenetic clocks	12
Advantages of vitrification preservation in assisted reproduction and potential influences on imprinted genes	12
Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes	12
The mediating effect of DNA methylation in the association between maternal sleep during pregnancy and offspring adiposity status: a prospective cohort study	12
Distinguishing transgender DNA methylation	12
Regional gain and global loss of 5-hydroxymethylcytosine coexist in genitourinary cancers and regulate different oncogenic pathways	12
Chidamide and venetoclax synergistically exert cytotoxicity on multiple myeloma by upregulating BIM expression	12
Interpretation of the role of germline and somatic non-coding mutations in cancer: expression and chromatin conformation informed analysis	12
Identification of DNA methylation-regulated genes as potential biomarkers for coronary heart disease via machine learning in the Framingham Heart Study	12
Methylation-derived inflammatory measures and lung cancer risk and survival	12
Dynamics of epigenetic regulator gene BCOR mutation and response predictive value for hypomethylating agents in patients with myelodysplastic syndrome	12