Clinical Epigenetics

Article	Citations
Circulating tumor DNA methylation marker MYO1-G for diagnosis and monitoring of colorectal cancer	145
Predicting male fertility from the sperm methylome: application to 120 bulls with hundreds of artificial insemination records	135
Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study	110
Tumor mutation burden involving epigenetic regulatory genes and the RhoA GTPase predicts overall survival in nodal mature T-cell lymphomas	88
Pre-implantation alcohol exposure induces lasting sex-specific DNA methylation programming errors in the developing forebrain	82
Lifetime exposure to smoking, epigenetic aging, and morbidity and mortality in older adults	76
Longitudinal profiling in patients undergoing cardiac surgery reveals postoperative changes in DNA methylation	67
Longitudinal monitoring of cell-free DNA methylation in ALK-positive non-small cell lung cancer patients	63
The role of epigenetic modifications for the pathogenesis of Crohn's disease	62
Low reliability of DNA methylation across Illumina Infinium platforms in cord blood: implications for replication studies and meta-analyses of prenatal exposures	55
Identification of DNA methylation markers for early detection of CRC indicates a role for nervous system-related genes in CRC	54
JIB-04, a histone demethylase Jumonji C domain inhibitor, regulates phenotypic switching of vascular smooth muscle cells	54
HDAC2 enhances esophageal squamous cell carcinoma development through down-regulating microRNA-503-5p and promoting CXCL10	52
Identification of ZBTB18 as a novel colorectal tumor suppressor gene through genome-wide promoter hypermethylation analysis	51
Integrative genomics analysis of nasal intestinal-type adenocarcinomas demonstrates the major role of CACNA1C and paves the way for a simple diagnostic tool in male woodworkers	50
Correction to: Integrative study of EZH2 mutational status, copy number, protein expression and H3K27 trimethylation in AML/MDS patients	50
Comprehensive analysis of PD-L1 expression, tumor-infiltrating lymphocytes, and tumor microenvironment in LUAD: differences between Asians and Caucasians	48
Whole-genome methylation analysis of testicular germ cells from cryptozoospermic men points to recurrent and functionally relevant DNA methylation changes	45
High performance methylated DNA markers for detection of colon adenocarcinoma	44
Immune profiles and DNA methylation alterations related with non-muscle-invasive bladder cancer outcomes	44
Decreased mitochondrial D-loop region methylation mediates an increase in mitochondrial DNA copy number in CADASIL	42
Correction to: Does the epigenetic clock GrimAge predict mortality independent of genetic influences: an 18 year follow-up study in older female twin pairs	41
The dark side of histones: genomic organization and role of oncohistones in cancer	41
Oxygen concentration affects de novo DNA methylation and transcription in in vitro cultured oocytes	40
Combined prenatal Lactobacillus reuteri and ω-3 supplementation synergistically modulates DNA methylation in neonatal T helper cells	39

DNA methylation patterns at and beyond the histological margin of early-stage invasive lung adenocarcinoma radiologically manifested as pure ground-glass opacity	38
Novel epigenetic network biomarkers for early detection of esophageal cancer	35
Effect of menopausal hormone therapy on methylation levels in early and late postmenopausal women	35
Bladder cancer detection in urine using DNA methylation markers: a technical and prospective preclinical validation	35
Psychostimulant-induced aberrant DNA methylation in an in vitro model of human peripheral blood mononuclear cells	35
Correction to: Chromatin insulation dynamics in glioblastoma: challenges and future perspectives of precision oncology	35
Novel genetic variants of KHDC3L and other members of the subcortical maternal complex associated with Beckwith–Wiedemann syndrome or Pseudohypoparathyroidism 1B and multi-locus imprinting disturbance	34
Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder	33
Investigating pathological epigenetic aberrations by epi-proteomics	32
Bisulfite profiling of the MGMT promoter and comparison with routine testing in glioblastoma diagnostics	32
Gender-affirming hormone therapy induces specific DNA methylation changes in blood	32
Genome-wide DNA methylation analysis of extreme phenotypes in the identification of novel epigenetic modifications in diabetic retinopathy	31
The emerging role of epigenetic regulation in the progression of silicosis	31
Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker	30
Temporal associations between leukocytes DNA methylation and blood lipids: a longitudinal study	30
Identification of differentially methylated regions in rare diseases from a single-patient perspective	29
Correction to: ZMYND10, an epigenetically regulated tumor suppressor, exerts tumor-suppressive functions via miR145-5p/NEDD9 axis in breast cancer	29
DNA methylation patterns associated with konzo in Sub-Saharan Africa	29
A randomized, phase II trial of oral azacitidine (CC-486) in patients with resected pancreatic adenocarcinoma at high risk for recurrence	29
Blood DNA methylation and COVID-19 outcomes	28
Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma	28
Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature	28
A critical appraisal of clinical epigenetics	28
Technical considerations in PCR-based assay design for diagnostic DNA methylation cancer biomarkers	28
Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: an EWAS in multi-ethnic Asian individuals	28
Hi-C profiling of cancer spheroids identifies 3D-growth-specific chromatin interactions in breast cancer endocrine resistance	27
DNA methylation regulates TIGIT expression within the melanoma microenvironment, is prognostic for overall survival, and predicts progression-free survival in patients treated with anti-PD-1 immunothe	26
Distinct modulation of IFNγ-induced transcription by BET bromodomain and catalytic P300/CBP inhibition in breast cancer	26
Betamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation	26
High-throughput and affordable genome-wide methylation profiling of circulating cell-free DNA by methylated DNA sequencing (MeD-seq) of LpnPI digested fragments	25
Why epigenetics is (not) a biosocial science and why that matters	25
Associations between indicators of socioeconomic position and DNA methylation: a scoping review	25
Identification of prognosis-related molecular subgroups based on DNA methylation in pancreatic cancer	25
Physical activity specifically evokes release of cell-free DNA from granulocytes thereby affecting liquid biopsy	25
DNA methylation-based detection and prediction of cervical intraepithelial neoplasia grade 3 and invasive cervical cancer with the WID™-qCIN test	25
H3K36 trimethylation-mediated biological functions in cancer	25
Disrupted methylation patterns at birth persist in early childhood: a prospective cohort analysis	24
Predictive biomarkers and potential drug combinations of epi-drugs in cancer therapy	24
Correction to: The tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/β‑catenin signaling	23
Pembrolizumab plus azacitidine in patients with chemotherapy refractory metastatic colorectal cancer: a single-arm phase 2 trial and correlative biomarker analysis	23
Clinical evaluation of Bladder CARE, a new epigenetic test for bladder cancer detection in urine samples	23
Epigenetically regulated PCDHB15 impairs aggressiveness of metastatic melanoma cells	23
Distinguishable DNA methylation defines disease susceptibility influenced by race and ethnicity	23
Whole blood methylome-derived features to discriminate endocrine hypertension	23
An EPIC predictor of gestational age and its application to newborns conceived by assisted reproductive technologies	22
The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes	22
Fibroblast growth factor (FGF), FGF receptor (FGFR), and cyclin D1 (CCND1) DNA methylation in head and neck squamous cell carcinomas is associated with transcriptional activity, gene amplification, hu	22
Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer	22
Transcriptional epigenetic regulation of Fkbp1/Pax9 genes is associated with impaired sensitivity to platinum treatment in ovarian cancer	22
An epigenome-wide study of DNA methylation profiles and lung function among American Indians in the Strong Heart Study	21

Correction to: The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability	21
Genome-wide promoter methylation profiling in a cellular model of melanoma progression reveals markers of malignancy and metastasis that predict melanoma survival	21
Cross talk between acetylation and methylation regulators reveals histone modifier expression patterns posing prognostic and therapeutic implications on patients with colon cancer	21
Methylated markers accurately distinguish primary central nervous system lymphomas (PCNSL) from other CNS tumors	21
Correction to: Silencing or inhibition of H3K79 methyltransferase DOT1L induces cell cycle arrest by epigenetically modulating c-Myc expression in colorectal cancer	20
The role of DNA methylation in syndromic and non-syndromic congenital heart disease	20
Multi-omic alterations of the SWI/SNF complex define a clinical subgroup in lung adenocarcinoma	20
Methylation status of nc886 epiallele reflects periconceptional conditions and is associated with glucose metabolism through nc886 RNAs	19
Guidelines for pre-analytical conditions for assessing the methylation of circulating cell-free DNA	19
Translation of a tissue epigenetic signature to circulating free DNA suggests BCAT1 as a potential noninvasive diagnostic biomarker for lung cancer	19
ZNF445: a homozygous truncating variant in a patient with Temple syndrome and multilocus imprinting disturbance	19
DNA 5-hydroxymethylcytosine in pediatric central nervous system tumors may impact tumor classification and is a positive prognostic marker	19
Epigenome-wide association study of level and change in cognitive abilities from midlife through late life	19
Leveraging epigenetics to enhance the efficacy of immunotherapy	19
DNA methylation of the KLK8 gene in depression symptomatology	19
Ultralow amounts of DNA from long-term archived serum samples produce high-quality methylomes	19
Correction to: Epigenetic targeting of the ACE2 and NRP1 viral receptors limits SARS‑CoV‑2 infectivity	18
Genome-wide methylation patterns in Marfan syndrome	18
Promoter methylation-mediated repression of UNC5 receptors and the associated clinical significance in human colorectal cancer	18
Impact of vitamin C supplementation on placental DNA methylation changes related to maternal smoking: association with gene expression and respiratory outcomes	18
Associations between DNA methylation and BMI vary by metabolic health status: a potential link to disparate cardiovascular outcomes	18
DNA methylation signatures associated with cardiometabolic risk factors in children from India and The Gambia: results from the EMPHASIS study	18
Longitudinal DNA methylation dynamics as a practical indicator in clinical epigenetics	18
Chromatin accessibility and transcriptome integrative analysis revealed AP-1-mediated genes potentially modulate histopathology features in psoriasis	18
Alterations of DNA methylation were associated with the rapid growth of cortisol-producing adrenocortical adenoma during pregnancy	18
Epigenetic adaptations of the masticatory mucosa to periodontal inflammation	17
Accurate prediction of acute pancreatitis severity based on genome-wide cell free DNA methylation profiles	17
Epigenetic targeting of the ACE2 and NRP1 viral receptors limits SARS-CoV-2 infectivity	17
Characteristics of epigenetic aging across gestational and perinatal tissues	17
Aberrant epigenetic and transcriptional events associated with breast cancer risk	17
Epimutations in both the TESK2 and MMACHC promoters in the Epi-cblC inherited disorder of intracellular metabolism of vitamin B12	17
Parthenogenetic mosaicism: generation via second polar body retention and unmasking of a likely causative PER2 variant for hypersomnia	17
Germline variants in genes of the subcortical maternal complex and Multilocus Imprinting Disturbance are associated with miscarriage/infertility or Beckwith–Wiedemann progeny	17
Differentially hypomethylated cell-free DNA and coronary collateral circulation	16
Comprehensive comparison between azacytidine and decitabine treatment in an acute myeloid leukemia cell line	16
Whole-blood methylation signatures are associated with and accurately classify multiple sclerosis disease severity	16
Incorporation of DNA methylation quantitative trait loci (mQTLs) in epigenome-wide association analysis: application to birthweight effects in neonatal whole blood	16
Increased copy number of imprinted genes in the chromosomal region 20q11-q13.32 is associated with resistance to antitumor agents in cancer cell lines	16
Transient Polycomb activity represses developmental genes in growing oocytes	16
Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells	16
Epigenetic silencing of JAM3 promotes esophageal cancer development by activating Wnt signaling	15
Integrated multi-omics analyses reveal that BCAM is associated with epigenetic modification and tumor microenvironment subtypes of clear cell renal cell carcinoma	15
Validating biomarkers and models for epigenetic inference of alcohol consumption from blood	15
Persistent blood DNA methylation changes one year after SARS-CoV-2 infection	15
Epigenetic mechanisms underlying prostate cancer radioresistance	15
Current understanding of epigenetics mechanism as a novel target in reducing cancer stem cells resistance	15
DNA methylation profiling for molecular classification of adult diffuse lower-grade gliomas	15
DNA methylation mediates the association between breastfeeding and early-life growth trajectories	15
BDNF exon IV promoter methylation and antidepressant action: a complex interplay	15
The role of epigenetic mechanisms in the regulation of gene expression in the cyclical endometrium	15
Cri du chat syndrome patients have DNA methylation changes in genes linked to symptoms of the disease	15
DNA methyltransferase inhibitors combination therapy for the treatment of solid tumor: mechanism and clinical application	15
HDAC8 suppresses the epithelial phenotype and promotes EMT in chemotherapy-treated basal-like breast cancer	14
The absence of AhR in CD4+ T cells in patients with acute graft-versus-host disease may be related to insufficient CTCF expression	14
Patients with PWS and related syndromes display differentially methylated regions involved in neurodevelopmental and nutritional trajectory	14
Genome-wide screening for differentially methylated long noncoding RNAs identifies LIFR-AS1 as an epigenetically regulated lncRNA that inhibits the progression of colorectal cancer	14
Prenatal and postnatal traffic pollution exposure, DNA methylation in Shank3 and MeCP2 promoter regions, H3K4me3 and H3K27me3 and sociability in rats’ offspring	14
Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy	14
Serum level of total histone 3, H3K4me3, and H3K27ac after non-emergent cardiac surgery suggests the persistence of smoldering inflammation at 3 months in an adult population	14
Interplay of Val66Met and BDNF methylation: effect on reward learning and cognitive performance in major depression	14
DNA methylation and behavioral dysfunction in males with 47,XXY and 49,XXXXY: a pilot study	13
Identification of DNA methylation biomarkers with potential to predict response to neoadjuvant chemotherapy in triple-negative breast cancer	13
Identification of influential probe types in epigenetic predictions of human traits: implications for microarray design	13
Differentially methylated CpGs in response to growth hormone administration in children with idiopathic short stature	13
Epigenetic age is associated with baseline and 3-year change in frailty in the Canadian Longitudinal Study on Aging	13
SETD2-mediated epigenetic regulation of noncanonical Wnt5A during osteoclastogenesis	13
A validation study of potential prognostic DNA methylation biomarkers in patients with acute myeloid leukemia using a custom DNA methylation sequencing panel	13
Aberrant hypomethylation at imprinted differentially methylated regions is involved in biparental placental mesenchymal dysplasia	13
Integrative analysis of DNA methylation and gene expression reveals key molecular signatures in acute myocardial infarction	13
Cell-free DNA 5-hydroxymethylcytosine profiles of long non-coding RNA genes enable early detection and progression monitoring of human cancers	13
Therapeutical interference with the epigenetic landscape of germ cell tumors: a comparative drug study and new mechanistical insights	13
DNA methylation analysis of tumor suppressor genes in liquid biopsy components of early stage NSCLC: a promising tool for early detection	13
Maternal epigenetic clocks measured during pregnancy do not predict gestational age at delivery or offspring birth outcomes: a replication study in metropolitan Cebu, Philippines	13
LINC00114 stimulates growth and glycolysis of esophageal cancer cells by recruiting EZH2 to enhance H3K27me3 of DLC1	13
Correction to: Evaluation of global and intragenic hypomethylation in colorectal adenomas improves patient stratification and colorectal cancer risk prediction	13
Sensitive detection of colorectal cancer in peripheral blood by a novel methylation assay	12
Identification of hepatocellular carcinoma subtypes based on PcG-related genes and biological relevance with cancer cells	12
DNA methylation in cord blood in association with prenatal depressive symptoms	12
Aorta-specific DNA methylation patterns in cell-free DNA from patients with bicuspid aortic valve-associated aortopathy	12
Epigenetics of single-site and multi-site atherosclerosis in African Americans from the Genetic Epidemiology Network of Arteriopathy (GENOA)	12

Mitochondrial DNA methylation profiling of the human prefrontal cortex and nucleus accumbens: correlations with aging and drug use	12
Epigenome-wide association study of bronchopulmonary dysplasia in preterm infants: results from the discovery-BPD program	12
Predicting disease-free survival in colorectal cancer by circulating tumor DNA methylation markers	12
Increased PARylation impacts the DNA methylation process in type 2 diabetes mellitus	12
Epigenome-wide DNA methylation profiling of conditioned pain modulation in individuals with non-specific chronic low back pain	12
DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function	12
DNA methylation of GFI1 as a mediator of the association between prenatal smoking exposure and ADHD symptoms at 6 years: the Hokkaido Study on Environment and Children’s Health	12
HPV infection and 5mC/5hmC epigenetic markers in penile squamous cell carcinoma: new insights into prognostics	12
Disease-associated DNA methylation signatures in esophageal biopsies of children diagnosed with Eosinophilic Esophagitis	12
Spatial epi-proteomics enabled by histone post-translational modification analysis from low-abundance clinical samples	12
Plasma lipid profiles in early adulthood are associated with epigenetic aging in the Coronary Artery Risk Development in Young Adults (CARDIA) Study	12
Data mining of bulk and single-cell RNA sequencing introduces OBI1-AS1 as an astrocyte marker with possible role in glioma recurrence and progression	11
Epigenetic modelling of former, current and never smokers	11
BladMetrix: a novel urine DNA methylation test with high accuracy for detection of bladder cancer in hematuria patients	11
NEFM DNA methylation correlates with immune infiltration and survival in breast cancer	11
Fetal exposure to phthalates and bisphenols and DNA methylation at birth: the Generation R Study	11
Bariatric surgery-induced weight loss and associated genome-wide DNA-methylation alterations in obese individuals	11
A novel DNA methylation signature associated with lymph node metastasis status in early gastric cancer	11
Shifts in the immunoepigenomic landscape of monocytes in response to a diabetes-specific social support intervention: a pilot study among Native Hawaiian adults with diabetes	11
Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning	11
Methyl-qPCR: a new method to investigate Epstein–Barr virus infection in post-transplant lymphoproliferative diseases	11
SEEMLIS: a flexible semi-automated method for enrichment of methylated DNA from low-input samples	11
First step towards a consensus strategy for multi-locus diagnostic testing of imprinting disorders	11
Liquid biopsies based on DNA methylation as biomarkers for the detection and prognosis of lung cancer	11
Associations among phthalate exposure, DNA methylation of TSLP, and childhood allergy	11
A deep learning model for early risk prediction of heart failure with preserved ejection fraction by DNA methylation profiles combined with clinical features	11
Methylated circulating tumor DNA as a biomarker for colorectal cancer diagnosis, prognosis, and prediction	11
Targeted demethylation of the SLC5A7 promotor inhibits colorectal cancer progression	11
Correction: miR-29c plays a suppressive role in breast cancer by targeting the TIMP3/STAT1/FOXO1 pathway	11
DNA methylation biomarkers of myocardial infarction and cardiovascular disease	11