OOIR: Observatory of International Research

Papers

(The TQCC of Clinical Epigenetics is 19. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Circulating tumor DNA methylation marker MYO1-G for diagnosis and monitoring of colorectal cancer	145
Predicting male fertility from the sperm methylome: application to 120 bulls with hundreds of artificial insemination records	135
Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study	110
Tumor mutation burden involving epigenetic regulatory genes and the RhoA GTPase predicts overall survival in nodal mature T-cell lymphomas	88
Pre-implantation alcohol exposure induces lasting sex-specific DNA methylation programming errors in the developing forebrain	82
Lifetime exposure to smoking, epigenetic aging, and morbidity and mortality in older adults	76
Longitudinal profiling in patients undergoing cardiac surgery reveals postoperative changes in DNA methylation	67
Longitudinal monitoring of cell-free DNA methylation in ALK-positive non-small cell lung cancer patients	63
The role of epigenetic modifications for the pathogenesis of Crohn's disease	62
Low reliability of DNA methylation across Illumina Infinium platforms in cord blood: implications for replication studies and meta-analyses of prenatal exposures	55
Identification of DNA methylation markers for early detection of CRC indicates a role for nervous system-related genes in CRC	54
JIB-04, a histone demethylase Jumonji C domain inhibitor, regulates phenotypic switching of vascular smooth muscle cells	54
HDAC2 enhances esophageal squamous cell carcinoma development through down-regulating microRNA-503-5p and promoting CXCL10	52
Identification of ZBTB18 as a novel colorectal tumor suppressor gene through genome-wide promoter hypermethylation analysis	51
Integrative genomics analysis of nasal intestinal-type adenocarcinomas demonstrates the major role of CACNA1C and paves the way for a simple diagnostic tool in male woodworkers	50
Correction to: Integrative study of EZH2 mutational status, copy number, protein expression and H3K27 trimethylation in AML/MDS patients	50
Comprehensive analysis of PD-L1 expression, tumor-infiltrating lymphocytes, and tumor microenvironment in LUAD: differences between Asians and Caucasians	48
Whole-genome methylation analysis of testicular germ cells from cryptozoospermic men points to recurrent and functionally relevant DNA methylation changes	45
High performance methylated DNA markers for detection of colon adenocarcinoma	44
Immune profiles and DNA methylation alterations related with non-muscle-invasive bladder cancer outcomes	44
Decreased mitochondrial D-loop region methylation mediates an increase in mitochondrial DNA copy number in CADASIL	42
Correction to: Does the epigenetic clock GrimAge predict mortality independent of genetic influences: an 18 year follow-up study in older female twin pairs	41
The dark side of histones: genomic organization and role of oncohistones in cancer	41
Oxygen concentration affects de novo DNA methylation and transcription in in vitro cultured oocytes	40
Combined prenatal Lactobacillus reuteri and ω-3 supplementation synergistically modulates DNA methylation in neonatal T helper cells	39

DNA methylation patterns at and beyond the histological margin of early-stage invasive lung adenocarcinoma radiologically manifested as pure ground-glass opacity	38
Novel epigenetic network biomarkers for early detection of esophageal cancer	35
Effect of menopausal hormone therapy on methylation levels in early and late postmenopausal women	35
Bladder cancer detection in urine using DNA methylation markers: a technical and prospective preclinical validation	35
Psychostimulant-induced aberrant DNA methylation in an in vitro model of human peripheral blood mononuclear cells	35
Correction to: Chromatin insulation dynamics in glioblastoma: challenges and future perspectives of precision oncology	35
Novel genetic variants of KHDC3L and other members of the subcortical maternal complex associated with Beckwith–Wiedemann syndrome or Pseudohypoparathyroidism 1B and multi-locus imprinting disturbance	34
Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder	33
Investigating pathological epigenetic aberrations by epi-proteomics	32
Bisulfite profiling of the MGMT promoter and comparison with routine testing in glioblastoma diagnostics	32
Gender-affirming hormone therapy induces specific DNA methylation changes in blood	32
Genome-wide DNA methylation analysis of extreme phenotypes in the identification of novel epigenetic modifications in diabetic retinopathy	31
The emerging role of epigenetic regulation in the progression of silicosis	31
Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarker	30
Temporal associations between leukocytes DNA methylation and blood lipids: a longitudinal study	30
Identification of differentially methylated regions in rare diseases from a single-patient perspective	29
Correction to: ZMYND10, an epigenetically regulated tumor suppressor, exerts tumor-suppressive functions via miR145-5p/NEDD9 axis in breast cancer	29
DNA methylation patterns associated with konzo in Sub-Saharan Africa	29
A randomized, phase II trial of oral azacitidine (CC-486) in patients with resected pancreatic adenocarcinoma at high risk for recurrence	29
Blood DNA methylation and COVID-19 outcomes	28
Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma	28
Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature	28
A critical appraisal of clinical epigenetics	28
Technical considerations in PCR-based assay design for diagnostic DNA methylation cancer biomarkers	28
Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: an EWAS in multi-ethnic Asian individuals	28
Hi-C profiling of cancer spheroids identifies 3D-growth-specific chromatin interactions in breast cancer endocrine resistance	27
DNA methylation regulates TIGIT expression within the melanoma microenvironment, is prognostic for overall survival, and predicts progression-free survival in patients treated with anti-PD-1 immunothe	26
Distinct modulation of IFNγ-induced transcription by BET bromodomain and catalytic P300/CBP inhibition in breast cancer	26
Betamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation	26
High-throughput and affordable genome-wide methylation profiling of circulating cell-free DNA by methylated DNA sequencing (MeD-seq) of LpnPI digested fragments	25
Why epigenetics is (not) a biosocial science and why that matters	25
Associations between indicators of socioeconomic position and DNA methylation: a scoping review	25
Identification of prognosis-related molecular subgroups based on DNA methylation in pancreatic cancer	25
Physical activity specifically evokes release of cell-free DNA from granulocytes thereby affecting liquid biopsy	25
DNA methylation-based detection and prediction of cervical intraepithelial neoplasia grade 3 and invasive cervical cancer with the WID™-qCIN test	25
H3K36 trimethylation-mediated biological functions in cancer	25
Disrupted methylation patterns at birth persist in early childhood: a prospective cohort analysis	24
Predictive biomarkers and potential drug combinations of epi-drugs in cancer therapy	24
Correction to: The tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/β‑catenin signaling	23
Pembrolizumab plus azacitidine in patients with chemotherapy refractory metastatic colorectal cancer: a single-arm phase 2 trial and correlative biomarker analysis	23
Clinical evaluation of Bladder CARE, a new epigenetic test for bladder cancer detection in urine samples	23
Epigenetically regulated PCDHB15 impairs aggressiveness of metastatic melanoma cells	23
Distinguishable DNA methylation defines disease susceptibility influenced by race and ethnicity	23
Whole blood methylome-derived features to discriminate endocrine hypertension	23
An EPIC predictor of gestational age and its application to newborns conceived by assisted reproductive technologies	22
The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes	22
Fibroblast growth factor (FGF), FGF receptor (FGFR), and cyclin D1 (CCND1) DNA methylation in head and neck squamous cell carcinomas is associated with transcriptional activity, gene amplification, hu	22
Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer	22
Transcriptional epigenetic regulation of Fkbp1/Pax9 genes is associated with impaired sensitivity to platinum treatment in ovarian cancer	22
An epigenome-wide study of DNA methylation profiles and lung function among American Indians in the Strong Heart Study	21

Correction to: The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability	21
Genome-wide promoter methylation profiling in a cellular model of melanoma progression reveals markers of malignancy and metastasis that predict melanoma survival	21
Cross talk between acetylation and methylation regulators reveals histone modifier expression patterns posing prognostic and therapeutic implications on patients with colon cancer	21
Methylated markers accurately distinguish primary central nervous system lymphomas (PCNSL) from other CNS tumors	21
Correction to: Silencing or inhibition of H3K79 methyltransferase DOT1L induces cell cycle arrest by epigenetically modulating c-Myc expression in colorectal cancer	20
The role of DNA methylation in syndromic and non-syndromic congenital heart disease	20
Multi-omic alterations of the SWI/SNF complex define a clinical subgroup in lung adenocarcinoma	20
Translation of a tissue epigenetic signature to circulating free DNA suggests BCAT1 as a potential noninvasive diagnostic biomarker for lung cancer	19
Methylation status of nc886 epiallele reflects periconceptional conditions and is associated with glucose metabolism through nc886 RNAs	19
Guidelines for pre-analytical conditions for assessing the methylation of circulating cell-free DNA	19
Epigenome-wide association study of level and change in cognitive abilities from midlife through late life	19
ZNF445: a homozygous truncating variant in a patient with Temple syndrome and multilocus imprinting disturbance	19
DNA 5-hydroxymethylcytosine in pediatric central nervous system tumors may impact tumor classification and is a positive prognostic marker	19
Ultralow amounts of DNA from long-term archived serum samples produce high-quality methylomes	19
Leveraging epigenetics to enhance the efficacy of immunotherapy	19
DNA methylation of the KLK8 gene in depression symptomatology	19