OOIR: Observatory of International Research

Papers

(The TQCC of Clinical Epigenetics is 18. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
DNA methylation patterns associated with konzo in Sub-Saharan Africa	124
Psychostimulant-induced aberrant DNA methylation in an in vitro model of human peripheral blood mononuclear cells	106
Novel genetic variants of KHDC3L and other members of the subcortical maternal complex associated with Beckwith–Wiedemann syndrome or Pseudohypoparathyroidism 1B and multi-locus imprinting disturbance	89
Longitudinal monitoring of cell-free DNA methylation in ALK-positive non-small cell lung cancer patients	87
Disrupted methylation patterns at birth persist in early childhood: a prospective cohort analysis	59
Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells	54
Whole blood methylome-derived features to discriminate endocrine hypertension	48
Genome-wide promoter methylation profiling in a cellular model of melanoma progression reveals markers of malignancy and metastasis that predict melanoma survival	46
An epigenome-wide study of DNA methylation profiles and lung function among American Indians in the Strong Heart Study	43
Cross talk between acetylation and methylation regulators reveals histone modifier expression patterns posing prognostic and therapeutic implications on patients with colon cancer	40
Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer	40
Maternal epigenetic clocks measured during pregnancy do not predict gestational age at delivery or offspring birth outcomes: a replication study in metropolitan Cebu, Philippines	36
First step towards a consensus strategy for multi-locus diagnostic testing of imprinting disorders	35
Predicting disease-free survival in colorectal cancer by circulating tumor DNA methylation markers	35
Fetal exposure to phthalates and bisphenols and DNA methylation at birth: the Generation R Study	32
Liquid biopsies based on DNA methylation as biomarkers for the detection and prognosis of lung cancer	32
Genome-wide distribution of histone trimethylation reveals a global impact of bisphenol A on telomeric binding proteins and histone acetyltransferase factors: a pilot study with human and in vitro dat	30
Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy	28
Aberrant DNA hydroxymethylation reshapes transcription factor binding in myeloid neoplasms	27
Dynamic patterns of blood lipids and DNA methylation in response to statin therapy	27
Maternal–fetal stress and DNA methylation signatures in neonatal saliva: an epigenome-wide association study	27
Altered DNA methylation in estrogen-responsive repetitive sequences of spermatozoa of infertile men with shortened anogenital distance	26
Epigenetics of type 2 diabetes and diabetes-related outcomes in the Strong Heart Study	23
OXTR DNA methylation differentiates men on the obesity spectrum with and without binge eating disorder	23
Association of nutritional glycaemic indices with global DNA methylation patterns: results from the Moli-sani cohort	23

The emerging role of epigenetic regulation in the progression of silicosis	22
JIB-04, a histone demethylase Jumonji C domain inhibitor, regulates phenotypic switching of vascular smooth muscle cells	21
Why epigenetics is (not) a biosocial science and why that matters	20
Identification of differentially methylated regions in rare diseases from a single-patient perspective	20
Investigating pathological epigenetic aberrations by epi-proteomics	20
A randomized, phase II trial of oral azacitidine (CC-486) in patients with resected pancreatic adenocarcinoma at high risk for recurrence	20
Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature	19
Integrated multi-omics analyses reveal that BCAM is associated with epigenetic modification and tumor microenvironment subtypes of clear cell renal cell carcinoma	19
Lifetime exposure to smoking, epigenetic aging, and morbidity and mortality in older adults	19
Epigenetic tumor heterogeneity in the era of single-cell profiling with nanopore sequencing	18
Serum level of total histone 3, H3K4me3, and H3K27ac after non-emergent cardiac surgery suggests the persistence of smoldering inflammation at 3 months in an adult population	18
Translation of a tissue epigenetic signature to circulating free DNA suggests BCAT1 as a potential noninvasive diagnostic biomarker for lung cancer	18