OOIR: Observatory of International Research

Papers

(The TQCC of Clinical Epigenetics is 19. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Psychostimulant-induced aberrant DNA methylation in an in vitro model of human peripheral blood mononuclear cells	153
Integrative genomics analysis of nasal intestinal-type adenocarcinomas demonstrates the major role of CACNA1C and paves the way for a simple diagnostic tool in male woodworkers	152
DNA methylation patterns associated with konzo in Sub-Saharan Africa	118
Novel genetic variants of KHDC3L and other members of the subcortical maternal complex associated with Beckwith–Wiedemann syndrome or Pseudohypoparathyroidism 1B and multi-locus imprinting disturbance	86
Longitudinal monitoring of cell-free DNA methylation in ALK-positive non-small cell lung cancer patients	78
Disrupted methylation patterns at birth persist in early childhood: a prospective cohort analysis	62
Novel epigenetic network biomarkers for early detection of esophageal cancer	61
Technical considerations in PCR-based assay design for diagnostic DNA methylation cancer biomarkers	60
Hi-C profiling of cancer spheroids identifies 3D-growth-specific chromatin interactions in breast cancer endocrine resistance	54
Multi-omic alterations of the SWI/SNF complex define a clinical subgroup in lung adenocarcinoma	53
An epigenome-wide study of DNA methylation profiles and lung function among American Indians in the Strong Heart Study	51
Genome-wide promoter methylation profiling in a cellular model of melanoma progression reveals markers of malignancy and metastasis that predict melanoma survival	51
Epigenetic adaptations of the masticatory mucosa to periodontal inflammation	46
Aberrant epigenetic and transcriptional events associated with breast cancer risk	44
Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer	42
Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells	42
Whole blood methylome-derived features to discriminate endocrine hypertension	40
Cross talk between acetylation and methylation regulators reveals histone modifier expression patterns posing prognostic and therapeutic implications on patients with colon cancer	39
DNA methyltransferase inhibitors combination therapy for the treatment of solid tumor: mechanism and clinical application	38
Validating biomarkers and models for epigenetic inference of alcohol consumption from blood	36
First step towards a consensus strategy for multi-locus diagnostic testing of imprinting disorders	35
Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy	33
Fetal exposure to phthalates and bisphenols and DNA methylation at birth: the Generation R Study	33
Predicting disease-free survival in colorectal cancer by circulating tumor DNA methylation markers	33
Maternal epigenetic clocks measured during pregnancy do not predict gestational age at delivery or offspring birth outcomes: a replication study in metropolitan Cebu, Philippines	33

Epigenetics of single-site and multi-site atherosclerosis in African Americans from the Genetic Epidemiology Network of Arteriopathy (GENOA)	32
Epigenome-wide DNA methylation profiling of conditioned pain modulation in individuals with non-specific chronic low back pain	32
Plasma lipid profiles in early adulthood are associated with epigenetic aging in the Coronary Artery Risk Development in Young Adults (CARDIA) Study	31
Genome-wide distribution of histone trimethylation reveals a global impact of bisphenol A on telomeric binding proteins and histone acetyltransferase factors: a pilot study with human and in vitro dat	31
Liquid biopsies based on DNA methylation as biomarkers for the detection and prognosis of lung cancer	30
Epigenome-wide association studies: current knowledge, strategies and recommendations	30
Epigenome-wide contributions to individual differences in childhood phenotypes: a GREML approach	30
Maternal–fetal stress and DNA methylation signatures in neonatal saliva: an epigenome-wide association study	29
Epigenome-wide association study of lung function in Latino children and youth with asthma	28
Reproductive history and blood cell DNA methylation later in life: the Young Finns Study	28
Genome‑wide profiling of DNA methylation and gene expression unravel the epigenetic landscape in diabetes-related hypothyroidism	28
Evaluation of global and intragenic hypomethylation in colorectal adenomas improves patient stratification and colorectal cancer risk prediction	27
Differential DNA methylation by early versus late parenteral nutrition in the PICU: a biological basis for its impact on emotional and behavioral problems documented 4 years later	26
The epigenetic etiology of cardiovascular disease in a longitudinal Swedish twin study	26
Epigenetic quantification of circulating immune cells in peripheral blood of triple-negative breast cancer patients	26
Dynamic patterns of blood lipids and DNA methylation in response to statin therapy	26
Differential DNA methylation and changing cell-type proportions as fibrotic stage progresses in NAFLD	25
Aberrant DNA hydroxymethylation reshapes transcription factor binding in myeloid neoplasms	25
The ENmix DNA methylation analysis pipeline for Illumina BeadChip and comparisons with seven other preprocessing pipelines	25
Epigenetics of type 2 diabetes and diabetes-related outcomes in the Strong Heart Study	25
Epigenetics of early-life adversity in youth: cross-sectional and longitudinal associations	25
Association of nutritional glycaemic indices with global DNA methylation patterns: results from the Moli-sani cohort	25
Integrated 5-hydroxymethylcytosine and fragmentation signatures as enhanced biomarkers in lung cancer	24
Therapeutic potential of inhibiting histone 3 lysine 27 demethylases: a review of the literature	24
OXTR DNA methylation differentiates men on the obesity spectrum with and without binge eating disorder	24
The emerging role of epigenetic regulation in the progression of silicosis	24
Altered DNA methylation in estrogen-responsive repetitive sequences of spermatozoa of infertile men with shortened anogenital distance	24
DNA methylation patterns at and beyond the histological margin of early-stage invasive lung adenocarcinoma radiologically manifested as pure ground-glass opacity	24
Correction to: ZMYND10, an epigenetically regulated tumor suppressor, exerts tumor-suppressive functions via miR145-5p/NEDD9 axis in breast cancer	23
Identification of differentially methylated regions in rare diseases from a single-patient perspective	23
A randomized, phase II trial of oral azacitidine (CC-486) in patients with resected pancreatic adenocarcinoma at high risk for recurrence	23
Bisulfite profiling of the MGMT promoter and comparison with routine testing in glioblastoma diagnostics	23
Why epigenetics is (not) a biosocial science and why that matters	22
Decreased mitochondrial D-loop region methylation mediates an increase in mitochondrial DNA copy number in CADASIL	22
Effects of stressful life-events on DNA methylation in panic disorder and major depressive disorder	22
High performance methylated DNA markers for detection of colon adenocarcinoma	22
Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: an EWAS in multi-ethnic Asian individuals	22
High-throughput and affordable genome-wide methylation profiling of circulating cell-free DNA by methylated DNA sequencing (MeD-seq) of LpnPI digested fragments	22
JIB-04, a histone demethylase Jumonji C domain inhibitor, regulates phenotypic switching of vascular smooth muscle cells	21
Distinguishable DNA methylation defines disease susceptibility influenced by race and ethnicity	21
Investigating pathological epigenetic aberrations by epi-proteomics	21
Lifetime exposure to smoking, epigenetic aging, and morbidity and mortality in older adults	21
Pre-implantation alcohol exposure induces lasting sex-specific DNA methylation programming errors in the developing forebrain	21
Promoter methylation-mediated repression of UNC5 receptors and the associated clinical significance in human colorectal cancer	20
DNA 5-hydroxymethylcytosine in pediatric central nervous system tumors may impact tumor classification and is a positive prognostic marker	20
Accurate prediction of acute pancreatitis severity based on genome-wide cell free DNA methylation profiles	20
Alterations of DNA methylation were associated with the rapid growth of cortisol-producing adrenocortical adenoma during pregnancy	20
Translation of a tissue epigenetic signature to circulating free DNA suggests BCAT1 as a potential noninvasive diagnostic biomarker for lung cancer	20
Integrated multi-omics analyses reveal that BCAM is associated with epigenetic modification and tumor microenvironment subtypes of clear cell renal cell carcinoma	20
Epigenetic targeting of the ACE2 and NRP1 viral receptors limits SARS-CoV-2 infectivity	20

Pembrolizumab plus azacitidine in patients with chemotherapy refractory metastatic colorectal cancer: a single-arm phase 2 trial and correlative biomarker analysis	20
Guidelines for pre-analytical conditions for assessing the methylation of circulating cell-free DNA	20
SETD2-mediated epigenetic regulation of noncanonical Wnt5A during osteoclastogenesis	19
Interplay of Val66Met and BDNF methylation: effect on reward learning and cognitive performance in major depression	19
Epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progression	19
The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes	19