OOIR: Observatory of International Research

Papers

(The TQCC of CNS & Neurological Disorders-Drug Targets is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Neuroprotection of Rotenone-Induced Parkinsonism by Ursolic Acid in PD Mouse Model	55
Scopolamine, a Toxin-Induced Experimental Model, Used for Research in Alzheimer’s Disease	48
Inflammation and Mitochondrial Dysfunction in Autism Spectrum Disorder	37
When Sick Brain and Hopelessness Meet: Some Aspects of Suicidality in the Neurological Patient	34
Benzodiazepines and Sleep Architecture: A Systematic Review	31
Role of Calcium Homeostasis in Ischemic Stroke: A Review	30
Neurodegenerative Diseases and Flavonoids: Special Reference to Kaempferol	28
MAPK: A Key Player in the Development and Progression of Stroke	26
Autoimmune Encephalitis: Current Knowledge on Subtypes, Disease Mechanisms and Treatment	24
Prospective Role of Polyphenolic Compounds in the Treatment of Neurodegenerative Diseases	23
Role of Vitamins in Neurodegenerative Diseases: A Review	21
Arachidonic Acid Derivatives and Neuroinflammation	20
Stingless Bee Honey Reduces Anxiety and Improves Memory of the Metabolic Disease-induced Rats	19
Detection, Treatment Planning, and Genetic Predisposition of Bruxism: A Systematic Mapping Process and Network Visualization Technique	19
ATP-sensitive Potassium Channel Subunits in Neuroinflammation: Novel Drug Targets in Neurodegenerative Disorders	18
Role of Brain-Gut-Microbiota Axis in Depression: Emerging Therapeutic Avenues	17
Current Strategies and Novel Drug Approaches for Alzheimer Disease	17
Persons with Co-Existing Neurological Disorders: Risk Analysis, Considerations and Management in COVID-19 Pandemic	17
Speech as a Biomarker for Depression	17
Levodopa Therapy for Parkinson's Disease: History, Current Status and Perspectives	17
Neural Basis of Dental Pulp Stem Cells and its Potential Application in Parkinson’s Disease	16
Modeling Parkinson’s Disease in Zebrafish	16
Valproic Acid and Propionic Acid Modulated Mechanical Pathways Associated with Autism Spectrum Disorder at Prenatal and Neonatal Exposure	16
The Effects and Regulatory Mechanism of Flavonoids from Stems and Leaves of Scutellaria baicalensis Georgi in Promoting Neurogenesis and Improving Memory Impairment Mediated by the BDNF-ERK-CREB Signa	16
Oxidative Stress in the Pathogenesis of Alzheimer’s Disease and Cerebrovascular Disease with Therapeutic Implications	16

Markers of Neuroinflammation in the Serum of Prepubertal Children with Fetal Alcohol Spectrum Disorders	14
Melatonin and Sleep Disturbances in Alzheimer’s Disease	14
Novel Targets Explored in the Treatment of Alcohol Withdrawal Syndrome	14
The MMP-2/TIMP-2 System in Alzheimer Disease	14
Neurological Associations of SARS-CoV-2 Infection: A Systematic Review	13
An Insight into Molecular Mechanisms and Novel Therapeutic Approaches in Epileptogenesis	13
Carvacrol as a Potential Neuroprotective Agent for Neurological Diseases: A Systematic Review Article	13
Sepsis-Associated Encephalopathy: Insight into Injury and Pathogenesis	13
Pharmacological Treatment of Diabetic Peripheral Neuropathy: An Update	13
Parkinson’s Disease: Is there a Role for Dietary and Herbal Supplements?	12
Arachidonic Acid Metabolites in Neurologic Disorders	12
Prospective Function of Different Antioxidant Containing Natural Products in the Treatment of Neurodegenerative Diseases	12
Microglial Cathepsin B and Porphyromonas gingivalis Gingipains as Potential Therapeutic Targets for Sporadic Alzheimer’s Disease	12
Understanding Abnormal c-JNK/p38MAPK Signaling in Amyotrophic Lateral Sclerosis: Potential Drug Targets and Influences on Neurological Disorders	12
Flavonoids from Stems and Leaves of Scutellaria baicalensis Georgi Regulate the Brain Tau Hyperphosphorylation at Multiple Sites Induced by Composited Aβ in Rats	11
Lipid Nanocarriers for Neurotherapeutics: Introduction, Challenges, Blood-brain Barrier, and Promises of Delivery Approaches	11
Smartphone Addiction among Students and its Harmful Effects on Mental Health, Oxidative Stress, and Neurodegeneration towards Future Modulation of Anti-Addiction Therapies: A Comprehensive Survey base	11
The locus of Action of CGRPergic Monoclonal Antibodies Against Migraine: Peripheral Over Central Mechanisms	11
Tumor Treating Fields – Behind and Beyond Inhibiting the Cancer Cell Cycle	11
Regulatory Role of Chinese Herbal Medicine in Regulated Neuronal Death	11
Dietary Nutrients and Prevention of Alzheimer’s Disease	10
Neuroprotective and Anti-Inflammatory Effects of Pioglitazone on Parkinson's Disease: A Comprehensive Narrative Review of Clinical and Experimental Findings	10
MCC950 Reduces Neuronal Apoptosis in Spinal Cord Injury in Mice	10
A Causal-Pathway Phenotype of Chronic Fatigue Syndrome due to Hemodialysis in Patients with End-Stage Renal Disease	10
Intracerebral Hemorrhage and Diabetes Mellitus: Blood-Brain Barrier Disruption, Pathophysiology and Cognitive Impairments	10
Migraine and Obesity: Is There a Relationship? A Systematic Review and Meta-Analysis of Observational Studies	10
Improvement of a Novel Proposal for Antioxidant Treatment Against Brain Damage Occurring in Ischemic Stroke Patients	10
The Development of a PBPK Model for Atomoxetine Using Levels in Plasma, Saliva and Brain Extracellular Fluid in Patients with Normal and Deteriorated Kidney Function	10
Role of Natural Plant Products Against Alzheimer’s Disease	10
Intestinal Barrier Dysfunction Participates in the Pathophysiology of Ischemic Stroke	9
Resolution-Associated Molecular Patterns (RAMPs) as Endogenous Regulators of Glia Functions in Neuroinflammatory Disease	9
Beyond the Obvious: Smoking and Respiratory Infection Implications on Alzheimer's Disease	9
Spastin Interacts with CRMP2 to Regulate Neurite Outgrowth by Controlling Microtubule Dynamics through Phosphorylation Modifications	9
Nanoparticles as Powerful Tools for Crossing the Blood-brain Barrier	9
Drosophila melanogaster a Versatile Model of Parkinson’s Disease	9
Rethinking Catatonia: New Insights from the Autism Spectrum	9
Structural Activity Relationship based Medicinal Perspectives of Pyrimidine Derivatives as Anti-Alzheimer’s Agents: A Comprehensive Review	9
Recent Advancement of Pyrazole Scaffold Based Neuroprotective Agents: A Review	9
Dopamine as a Potential Target for Learning and Memory: Contributing to Related Neurological Disorders	8
Oxytocin Effect in Adult Patients with Autism: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials	8
Neurokinin-1 Receptor Antagonist Reverses Functional CNS Alteration Caused by Combined γ-rays and Carbon Nuclei Irradiation	8
Nanoparticles Based Intranasal Delivery of Drug to Treat Alzheimer’s Disease: A Recent Update	8
Deciphering the Role of Aberrant Protein Post-Translational Modification in the Pathology of Neurodegeneration	8
A Pivotal Role of the Nrf2 Signaling Pathway in Spinal Cord Injury: A Prospective Therapeutics Study	8
Design and Microwave-Assisted Synthesis of Aza-Resveratrol Analogs with Potent Cholinesterase Inhibition	8
The Mechanism of Action of Salsolinol in Brain: Implications in Parkinson’s Disease	8
Importance of Zebrafish as an Efficient Research Model for the Screening of Novel Therapeutics in Neurological Disorders	8
Tremor and Rigidity in Patients with Parkinson’s Disease: Emphasis on Epidemiology, Pathophysiology and Contributing Factors	8
GluN2B/N-methyl-D-aspartate Receptor Antagonists: Advances in Design, Synthesis, and Pharmacological Evaluation Studies	8
Overview of Therapeutic Drugs and Methods for the Treatment of Parkinson’s Disease	8

A Review on Autism Spectrum Disorder: Pathogenesis, Biomarkers, Pharmacological and Non-Pharmacological Interventions	7
Stroke and Vascular Cognitive Impairment: The Role of Intestinal Microbiota Metabolite TMAO	7
Exploring the Various Aspects of Brain-Derived Neurotropic Factor (BDNF) in Diabetes Mellitus	7
Mechanistic Insight and Possible Mechanism of Seizure in Covid-19: The Nuances and Focal Points	7
Management of Impulse Control Disorders with Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease	7
Effects of α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator on BDNF, NKCC1 and KCC2 Expression in the Hippocampus following Lipopolysaccharide-Induced Allodynia and Hyperalgesia in a	7
Cenobamate: A Review of its Pharmacological Properties, Clinical Efficacy and Tolerability Profile in the Treatment of Epilepsy	7
Nanotechnology: Its Application in Treating Neurodegenerative Diseases	7
Beta-Caryophyllene, a CB2R Selective Agonist, Protects Against Cognitive Impairment Caused by Neuro-inflammation and Not in Dementia Due to Ageing Induced by Mitochondrial Dysfunction	7
Transdermal Drug Delivery Systems and their Potential in Alzheimer’s Disease Management	7
Neuroprotective Role of the B Vitamins in the Modulation of the Central Glutamatergic Neurotransmission	7
Role of Forkhead Transcription Factors of the O Class (FoxO) in Development and Progression of Alzheimer’s Disease	7
Elucidations of Molecular Mechanism and Mechanistic Effects of Environmental Toxicants in Neurological Disorders	7
APOE4 is a Risk Factor and Potential Therapeutic Target for Alzheimer's Disease	6
Nanomedicinal Strategies as Emerging Therapeutic Avenues to Treat and Manage Cerebral Ischemia	6
Immunotherapies for Parkinson’s Disease: Progression of Clinical Development	6
Rationalizing the Use of Polyphenol Nano-formulations in the Therapy of Neurodegenerative Diseases	6
Targeting Microglial Polarization to Improve TBI Outcomes	6
Neurorestoratology: New Advances in Clinical Therapy	6
Lactose and Casein Cause Changes on Biomarkers of Oxidative Damage and Dysbiosis in an Experimental Model of Multiple Sclerosis	6
Effectiveness and Safety Profile of Ginkgo biloba Standardized Extract (EGb761®) in Patients with Amnestic Mild Cognitive Impairment	6
Transdermal Nutraceuticals Delivery System for CNS Disease	6
Targeted Delivery of Montelukast for the Treatment of Alzheimer’s Disease	6
The AMPAR Antagonist Perampanel Regulates Neuronal Necroptosis via Akt/GSK3β Signaling After Acute Traumatic Injury in Cortical Neurons	6
The Role of Statins in the Management of Delirium: Recent Advances	6
CGRP and CGRP-Receptor as Targets of Migraine Therapy: Brain Prize-2021	6
Pharmacological and Pathological Relevance of S100 Proteins in Neurological Disorders	6
Non-hepatic Hyperammonemia: A Potential Therapeutic Target for Sepsis-associated Encephalopathy	6
Integrated System Pharmacology and In Silico Analysis Elucidating Neuropharmacological Actions of Withania somnifera in the Treatment of Alzheimer’s Disease	6
Biomarker Validation of a New Case Definition of Menstrual Cycle-Associated Syndrome (MCAS) Opinion Paper	6
Anti-Neuropathic Pain Activity of Ageratum conyzoides L due to the Essential Oil Components	6
A Concise Review of Common Plant-derived Compounds as a Potential Therapy for Alzheimer's Disease and Parkinson's Disease: Insight into Structure-Activity-Relationship	6
Impact of the COVID-19 Pandemic on Chronic Neurological Disorders: Focus on Patients with Dementia	6
COVID-19, the Brain, and the Future: Is Infection by the Novel Coronavirus a Harbinger of Neurodegeneration?	5
1,3,5-Pyrazoline Derivatives in CNS Disorders: Synthesis, Biological Evaluation and Structural Insights through Molecular Docking	5
A Critical Analysis of Quercetin as the Attractive Target for the Treatment of Parkinson's Disease	5
Phytotherapeutics against Alzheimer’s Disease: Mechanism, Molecular Targets and Challenges for Drug Development	5
Gut-Brain Axis and Neurological Disorders-How Microbiomes Affect our Mental Health	5
Rolipram Rescues Memory Consolidation Deficits Caused by Sleep Deprivation: Implication of the cAMP/PKA and cAMP/Epac Pathways	5
The β-Secretase Enzyme BACE1: A Biochemical Enigma for Alzheimer’s Disease	5
Cardiac Biomarkers in Stroke, Alzheimer’s Disease, and Other Dementia. Are They of Use? A Brief Overview of Data from Recent Investigations	5
Age and Dose-Dependent Effects of Alpha-Lipoic Acid on Human Microtubule- Associated Protein Tau-Induced Endoplasmic Reticulum Unfolded Protein Response: Implications for Alzheimer’s Disease	5
Ethanolamine: A Potential Promoiety with Additional Effects on the Brain	5
Radiotherapy and Its Impact on the Nervous System of Cancer Survivors	5
The Endocannabinoid System and Alcohol Dependence: Will Cannabinoid Receptor 2 Agonism be More Fruitful than Cannabinoid Receptor 1 Antagonism?	5
Dopaminergic Signaling as a Plausible Modulator of Astrocytic Toll-Like Receptor 4: A Crosstalk between Neuroinflammation and Cognition	5
Melatonin Alleviates Pyroptosis of Retinal Neurons Following Acute Intraocular Hypertension	5
Acetylcholinesterase Enzyme Inhibitor Molecules with Therapeutic Potential for Alzheimer's Disease	5
In Vitro and In Vivo Neuroprotective Effects of Etifoxine in β-Amyloidinduced Toxicity Models	5
Fibrosis and Regulation of Nerve Regeneration in the Peripheral and Central Nervous Systems	5
Impact of Cannabis-Based Medicine on Alzheimer’s Disease by Focusing on the Amyloid β-Modifications: A Systematic Study	5
Interlink Between Insulin Resistance and Neurodegeneration with an Update on Current Therapeutic Approaches	5
Comparison of the Sedative Effect of Ketamine, Magnesium Sulfate, and Propofol in Patients Undergoing Upper Gastrointestinal Endoscopy: Double-Blinded Randomized Clinical Trial	5
Natural Products as Bioactive Agents in the Prevention of Dementia	5
Histone Deacetylase Inhibitors Prevented the Development of Morphine Tolerance by Decreasing IL6 Production and Upregulating μ-Opioid Receptors	5
Molecular and Biochemical Pathways Encompassing Diabetes Mellitus and Dementia	5
Circular RNAs in Alzheimer’s Disease: A New Perspective of Diagnostic and Therapeutic Targets	5
Quantitative Characterization of Phenotypical Markers After Differentiation of SH-SY5Y Cells	5
Pharmacotherapeutic Potential of Garlic in Age-Related Neurological Disorders	5
Myasthenia Gravis and Vitamin D Serum Levels: A Systematic Review and Meta-analysis	5
Temozolomide Resistance: A Multifarious Review on Mechanisms Beyond O-6-Methylguanine-DNA Methyltransferase	5