OOIR: Observatory of International Research

Papers

(The TQCC of CNS & Neurological Disorders-Drug Targets is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Meet the Editorial Board Member	67
Beyond Dopamine: Novel Therapeutic Pathways for Parkinson's Disease Through Receptor Signaling	63
Hypoxia-inducible Factor-1α Pathway in Cerebral Ischemia: From Molecular Mechanisms to Therapeutic Targets	44
Meet the Editorial Board Member	38
Meet the Editorial Board Member	36
Acetylcholinesterase Enzyme Inhibitor Molecules with Therapeutic Potential for Alzheimer's Disease	32
Migraine and Obesity: Is There a Relationship? A Systematic Review and Meta-Analysis of Observational Studies	25
Deciphering the Role of Peroxisome Proliferator-activated Receptor α and Phosphodiesterase Type 5 Targets in Alzheimer's Disease	24
Dopamine Depletion in Parkinson’s Disease and Therapeutic Options	23
Traumatic Brain Injury in COVID-19 Patients with the Manifestation of Paroxysmal Sympathetic Hyperactivity and Cytokine Storm	22
The Potential Effect of Blueberry on Cognitive Health and Mood State based on Human Intervention Studies: Systematic Review and Mini Meta-Analysis	20
Neurobiology of Amphetamine use in Stroke Recovery Combined with Rehabilitative Training and Brain Stimulation	20
Emerging Nanotechnology for the Treatment of Alzheimer’s Disease	19
A Review on Autism Spectrum Disorder: Pathogenesis, Biomarkers, Pharmacological and Non-Pharmacological Interventions	18
Meet the Editorial Board Member	18
Emerging Promise of Phytochemicals in Ameliorating Neurological Disorders	17
Meet the Editorial Board Member	17
Meet the Regional Editor	17
The Peripheral Profile of the Chitinase 3-like-1 in Benign Multiple Sclerosis – A Single Centre’s Experience	17
Meet Our Editorial Board Member	17
Herbal Drug Interaction: Mechanistic Details through Pharmacokinetic Portfolio	17
Evaluation of Associated Genes with Traumatic Pain: A Systematic Review	16
Drosophila melanogaster a Versatile Model of Parkinson’s Disease	16
Crosstalk between SARS-CoV-2 Infection and Neurological Disorders: A Review	16
A Comprehensive Review on Therapeutic Potential of Chrysin in Brain Related Disorders	16

Atorvastatin Prevents the Neuron Loss in the Hippocampal Dentate Gyrus Region through its Anti-Oxidant and Anti-Apoptotic Activities	16
Chemical Kindling as an Experimental Model to Assess the Conventional Drugs in the Treatment of Post-traumatic Epilepsy	16
Therapeutic Viewpoint on Rat Models of Locomotion Abnormalities and Neurobiological Indicators in Parkinson's Disease	16
CRISPR/Cas9 Gene Editing: A Novel Approach Towards Alzheimer's Disease Treatment	16
The Natural Neuroprotective Compounds Used in the 6-Hydroxydopamine- Induced Parkinson’s Disease in Zebrafish: The Current Applications and Perspectives	16
Modulation of Huntington’s Disease in Drosophila	15
Application of Herbs and Dietary Supplements in ADHD Management	15
Update on Oxytocin, Phosphodiesterase, Neurokinin, Glycine as a Therapeutic Approach in the Treatment of Schizophrenia	15
Barbigerone against Lipopolysaccharide-Induced Memory Deficit in Rodents via Alteration of Inflammatory and Oxidative Stress Pathway: In vivo and Molecular Dynamics Simulations Study	14
Conifer Essential Oils Reversed Amyloid Beta1-42 Action by Modulating BDNF and ARC Expression in The Rat Hippocampus	14
Targeted Delivery of Montelukast for the Treatment of Alzheimer’s Disease	14
Recent Trends in Physical Therapy Interventions and Neuromodulation Techniques to Improve Neurorehabilitation	14
Restless Leg Syndrome in Patients with Liver Cirrhosis! Its Frequency, Severity, and Correlation	13
Nanotechnological Advances in the Treatment of Epilepsy	13
The Current Evidence for the Therapeutic Role of Curcumin in Alzheimer’s Disease	13
Prospective Role of Polyphenolic Compounds in the Treatment of Neurodegenerative Diseases	13
Nutrition, Immunity and Aging: Current Scenario and Future Perspectives in Neurodegenerative Diseases	13
Mycotoxins and Amyotrophic Lateral Sclerosis: Food Exposure, Nutritional Implications and Dietary Solutions	13
A Review of Clinical Studies Assessing the Therapeutic Efficacy of Escitalopram: A Step Towards Development	12
Endophenotypes and Pathway Phenotypes in Neuro-psychiatry: Crossdisciplinary Implications for Diagnosis	12
Rolipram Rescues Memory Consolidation Deficits Caused by Sleep Deprivation: Implication of the cAMP/PKA and cAMP/Epac Pathways	12
Herbal Approaches in the Management of Mental Depression	12
Magic Shotgun Nature with Scattergun Approach of Curcumin Repurposing in Obsessive-compulsive Disorder: A Novel Metaphysician of Drug Discovery	12
The Use of Midazolam as an Antiseizure Medication in Neonatal Seizures: Single Center Experience and Literature Review	12
Cellular Senescence and ApoE4: Their Repercussions in Alzheimer’s Disease	12
Arachidonic Acid Metabolites in Neurologic Disorders	12
The Role of Glial Cells in Autism Spectrum Disorder: Molecular Mechanisms and Therapeutic Approaches	12
Ablation of Shank1 Protects against 6-OHDA-induced Cytotoxicity via PRDX3-mediated Inhibition of ER Stress in SN4741 Cells	11
Na+/HCO3− Co-transporters Inhibitor S0859 Attenuates Global Cerebral Ischemia-reperfusion Injury of the CA1 Neurons in the Gerbil’s Hippocampus	11
Recent Trends in Nano-Particulate Carriers for the Diagnosis and Treatment of Alzheimer’s Disease	11
Effects of α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator on BDNF, NKCC1 and KCC2 Expression in the Hippocampus following Lipopolysaccharide-Induced Allodynia and Hyperalgesia in a	11
Mini-Review on SARS-CoV-2 Infection and Neurological Manifestations: A Perspective	11
Anti-seizure Medications: Challenges and Opportunities	11
Biomarker Validation of a New Case Definition of Menstrual Cycle-Associated Syndrome (MCAS) Opinion Paper	11
Dietary Xylitol Supplement Ameliorated AD-related Neuronal Injury by Regulating Glucose Metabolism Relevant Amino Acids in Mice	11
Decoding the Inter-Relationship between Sleep Disorders and Alzheimer’s Disease Pathogenesis	11
The Role of Monoamine Oxidase B Inhibitors in the Treatment of Parkinson’s Disease - An Update	10
Role of Vitamins in Neurodegenerative Diseases: A Review	10
Memory Reflections of the Microbiota-Gut and Oligodendrocyte Axis	10
Rationale and Development of Tavapadon, a D1/D5-Selective Partial Dopamine Agonist for the Treatment of Parkinson’s Disease	10
MCC950 Reduces Neuronal Apoptosis in Spinal Cord Injury in Mice	10
Impact of Dimethylfumarate on Sleep in Multiple Sclerosis Patients: An Actigraphic Study	10
Pharmacotherapeutic Potential of Garlic in Age-Related Neurological Disorders	10
Mini Review on Cariprazine: A Promising Antipsychotic Agent	10
Neuroblastoma and Stem Cell Therapy: An Updated Review	9
Identification of Known Flavonoids of Ficus carica L. as Aldose Reductase Inhibitors in Sciatic Nerve of Diabetic Neuropathy-induced Rats through Bioinformatics and Proteomics Analysis	9
Hypomyelination with Atrophy of Basal Ganglia and Cerebellum (HABC) Due to UFM1 Mutation in Roma Patients - Severe Early Encephalopathy with Stridor and Severe Hearing and Visual Impairment. A Single	9
Acute Phenobarbital Poisoning for the Management of Seizures in Newborns and Children; A Systematic Literature Review	9
A New Paradigm in Spinal Cord Injury Therapy: from Cell-free Treatment to Engineering Modifications	9
Therapeutic Potential of Myricetin in the Treatment of Neurological, Neuropsychiatric, and Neurodegenerative Disorders	9

Alzheimer Disease and Sleep Disorders: Insights into the Possible Disease Connections and the Potential Therapeutic Targets (Part II)	9
Immunotherapy for Pediatric Gliomas: CAR-T Cells Against B7H3: A Review of the Literature	9
Circadian Rhythms and Sleep Disorders Associated to Major Depressive Disorder: Pathophysiology and Therapeutic Opportunities	9
The Protective Role of L-carnitine on Psychosocial Stress-induced Changes in Gene Expression and Protein Levels of Matrix Metalloproteinases, Serum Corticosterone in a Rat Model	8
Design and Molecular Docking Studies of N-Mannich Base Derivatives of Primaquine Bearing Isatin on the Targets involved in the Pathophysiology of Cerebral Malaria	8
Meet the Editorial Board Member	8
Current Drug Targets in Alzheimer’s Associated Memory Impairment: A Comprehensive Review	8
Evaluating the Potential of Light Exposure on Reducing the Frequency of Epileptic Seizures	8
Meet Our Regional Editor	8
Unraveling the Role of Neuroligin3 in Autism Spectrum Disorders: Pathophysiological Insights and Targeted Therapies	7
LRRK2; Communicative Role in the Treatment of Parkinson’s Disease and Ulcerative Colitis Overlapping	7
Neurological Manifestations of COVID-19 and the Importance of Magnetic Resonance Imaging	7
Dioclea Altissima Seed Lectin (DAL) Prevents Anxiety-like Behavioral Responses in Adult Zebrafish (Danio Rerio): Involvement of GABAergic and 5-HT Systems	7
New Insights into the Relationship between Nutrition and Neuroinflammation in Alzheimer's Disease: Preventive and Therapeutic Perspectives	7
Nanoparticles as Powerful Tools for Crossing the Blood-brain Barrier	7
Neurological Complications Caused by Human Immunodeficiency Virus (HIV) and Associated Opportunistic Co-infections: A Review on their Diagnosis and Therapeutic Insights	7
Cholinesterase Inhibitory and In Silico Toxicity Assessment of Thirty-Four Isoquinoline Alkaloids - Berberine as the Lead Compound	7
Sleep-Related Disorders in Parkinson's Disease: Mechanisms, Diagnosis, and Therapeutic Approaches	7
A Review of Antidepressant Effects and Mechanisms of Three Common Herbal Medicines: Panax ginseng, Bupleurum chinense, and Gastrodia elata	7
Treatment of Catatonia with Asenapine in a Patient with Schizotypal Personality Disorder, Psychotic Depression and Septic Shock from SARSCoV- 2 - A Case Report	7
Neuroprotective Efficacy of Edaravone against Arsenic-Induced Behavioral and Neurochemical Deficits in Rats: Amelioration of Cholinergic and Mitochondrial Functions	7
Link of COVID-19 and Neurodegenerative Disorders	7
Mechanistic Study on the Possible Role of Embelin in Treating Neurodegenerative Disorders	7
Importance of Pharmacophore in Designing Anticonvulsant Agents	7
Immunotherapeutics for AD: A Work in Progress	7
Transdermal Nutraceuticals Delivery System for CNS Disease	7
Treatment and Management of Autosomal Recessive Cerebellar Ataxias: Current Advances and Future Perspectives	7
Meet the Editorial Board Member	7
Implication of Covid-19 on Neurological Complications with Specific Emphasis on Alzheimer’s and Parkinson’s Disease	7
Strategic Approaches to Target the Enzymes using Natural Compounds for the Management of Alzheimer’s Disease: A Review	7
Comparison of Safety and Effectiveness between Levetiracetam and Phenytoin in the Treatment of Pediatric Status Epilepticus: A Meta- Analysis	7
Recent Advancement of Pyrazole Scaffold Based Neuroprotective Agents: A Review	6
Molecular and Biochemical Pathways Encompassing Diabetes Mellitus and Dementia	6
GluN2B/N-methyl-D-aspartate Receptor Antagonists: Advances in Design, Synthesis, and Pharmacological Evaluation Studies	6
GFAP and UCHL1 in Non-traumatic SAH: The Story thus Far. A Systematic Review of the Literature	6
The Alpha-7 Nicotinic Receptor Positive Allosteric Modulator PNU120596 Attenuates Lipopolysaccharide-Induced Depressive-Like Behaviors and Cognitive Impairment by Regulating the PPAR-α Signaling Pathw	6
Does Human Alpha-Synuclein Behave Like Prions?	6
G Protein-coupled Receptors (GPCRs) as Potential Therapeutics for Psychiatric Disorders	6
An Insight into the Role of Artificial Intelligence in the Early Diagnosis of Alzheimer’s Disease	6
T Lymphocyte Interferon-gamma Response to Anaplasmataceae-related Major Surface Proteins and Ankyrin A in Fibromyalgia	6
Neurotrophin-3 Rescues Striatal Synaptic Plasticity in Model of Neurodegeneration by PLC Signaling Activation	6
Bumetanide, a Diuretic That Can Help Children with Autism Spectrum Disorder	6
BBBper: A Machine Learning-based Online Tool for Blood-Brain Barrier (BBB) Permeability Prediction	6
Navigating into the Paradigm of Nose-to-brain Delivery of Nanotherapeutics and their Repurposing as Nanotheranostics for Neurodegenerative Diseases	6
Amelioration of Neurochemical Alteration and Memory and Depressive Behavior in Sepsis by Allopurinol, a Tryptophan 2,3-Dioxygenase Inhibitor	6
Effect of Natural Plant Products on Alzheimer’s Disease	6
Pharmacogenetics of Carbamazepine: A Systematic Review on CYP3A4 and CYP3A5 Polymorphisms	6
Neurokinin-1 Receptor Antagonist Reverses Functional CNS Alteration Caused by Combined γ-rays and Carbon Nuclei Irradiation	5
The Impact of ROS and NGF in the Gliomagenesis and their Emerging Implications in the Glioma Treatment	5
Elucidations of Molecular Mechanism and Mechanistic Effects of Environmental Toxicants in Neurological Disorders	5
Emergence of Sexual Dreams and Emission Following Deep Transcranial Magnetic Stimulation over the Medial Prefrontal and Cingulate Cortices	5
Modifiable Risk Factors Associated with Alzheimer’s Disease with Special Reference to Sleep Disturbance	5
Deciphering the Influence of Cigarette Smoke Carcinogens on CNS Associated Biomolecules: A Computational Synergistic Approach	5
Genetic Causes of Alzheimer’s Disease and the Neuroprotective Role of Melatonin in its Management	5
Importance of Exploring N-Methyl-D-Aspartate (NMDA) as a Future Perspective Target in Depression	5
Beta-Caryophyllene, a CB2R Selective Agonist, Protects Against Cognitive Impairment Caused by Neuro-inflammation and Not in Dementia Due to Ageing Induced by Mitochondrial Dysfunction	5
Intracerebral Hemorrhage and Diabetes Mellitus: Blood-Brain Barrier Disruption, Pathophysiology and Cognitive Impairments	5
Towards a Systemic Concept of the Brain Ishemia Stroke: Monte Carlo Driven in silico Model	5
Circular RNAs in Alzheimer’s Disease: A New Perspective of Diagnostic and Therapeutic Targets	5
Role of Natural Plant Products Against Alzheimer’s Disease	5
Regulatory Role of Chinese Herbal Medicine in Regulated Neuronal Death	5
Gut-Brain Axis and Neurological Disorders-How Microbiomes Affect our Mental Health	5
Amyloid Beta Peptide-Mediated Alterations in Mitochondrial Dynamics and its Implications for Alzheimer’s Disease	5
Melatonin Alleviates Pyroptosis of Retinal Neurons Following Acute Intraocular Hypertension	5
Nordihydroguaiaretic Acid Affects Undifferentiated and Differentiated Neuroblastoma Cells Differently through Mechanisms that Impact on Cell Viability	5
Danshensu Enhances Cerebral Angiogenesis in Mice by Regulating the PI3K/Akt/Mtor/VEGF Signaling Axis	5
Monoamine Oxidase: A Potential Link in Papez Circuit to Generalized Anxiety Disorders	5
The Emerging Role of Marine Natural Products for the Treatment of Parkinson’s Disease	5
Neuroregenerative Activity of the Dipeptide Mimetic of Brain-derived Neurotrophic Factor GSB-106 Under Experimental Ischemic Stroke	5
Exploring the Pharmacological Effects of Bioactive Peptides on Human Nervous Disorders: A Comprehensive Review	5
Nicotine Abuse and Neurodegeneration: Novel Pharmacogenetic Targets to Aid Quitting and Reduce the Risk of Dementia	5
Immunotherapies for Parkinson’s Disease: Progression of Clinical Development	5