OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Pharmaceutical Innovation is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Editorial: Biopharmaceutical Innovation	63
Development and Characterization of Copper Cross-Linked Freeze-Dried Bioscaffolds for Potential Wound Healing Activity	26
Bioavailability Enhancement of Poorly Aqueous Soluble Atorvastatin Calcium by Solid Dispersion Technique Using a Modified Natural Polymer as a Hydrophilic Carrier	24
Gastroprotective Efficacy of Prebiotic-based Oral Formulation of Amoxicillin	20
A Gel-Free Reservoir System for Once-a-Day Ophthalmic Delivery of Timolol Maleate	19
Baicalein-Loaded Aspasomal Formulations: Development, Characterization and Evaluation of Antioxidant and Anti-Inflammatory Effects	18
Comparative Study of a Novel Micro-feeder and Loss-in-weight Feeders	18
A Multitargeted Approach to Breast Cancer Therapy: Exploring the Therapeutic Potential of Afzelin as a Combination Agent with FDA-Approved Breast Cancer Drugs	17
Hemoglobin-Polyvinyl Alcohol (Hb-PVA) Macroporous Cryogels As Swelling-Controlled Drug Delivery System Optimization and Release Kinetics of Vancomycin	16
Novel Ketoconazole-Loaded Niosomal Gel with Carbamide for Enhanced Topical Delivery and Skin Hydration in Fungal Infections	15
Accelerated Approval for Cancer Drugs in the United States and the Clinical Evidence Required for Conversion to Regular Approval	14
A Novel CFD Model of SMX Static Mixer Used in Advanced Continuous Manufacturing of Active Pharmaceutical Ingredients (API)	13
Lutein and β-Carotene Characterization in Free and Nanodispersion Forms in Terms of Antioxidant Activity and Cytotoxicity	13
Fabrication of Zein-Chitosan-Zein Sandwich-Like Nanofibers Containing Teicoplanin as a Local Antibacterial Drug Delivery System	13
Passive Targeted Drug Delivery of Venlafaxine HCl to the Brain by Modified Chitosan Nanoparticles: Characterization, Cellular Safety Assessment, and In Vivo Evaluation	13
A Novel Prednisolone-Loaded Layer-by-Layer Nanoparticles (LBL-NPs) for Rheumatoid Arthritis: Optimization and Therapeutic Evaluation	13
Preparation and Evaluation of N-Acetyl D-Glucosamine Ethosomal Gel for the Treatment of Hyperpigmentation	12
Colloidal Copper Nanoparticles Loaded with Vanillic Acid as Liquid Dressings: Development, Characterisation and Evaluation	12
Surface Functionalization of Piperine-Loaded Liposomes with Sophorolipids Improves Drug Loading and Stability	12
“Therapeutic Potential of Boswellic Acid-Loaded Nanostructured Lipid Carriers in Aloe Gel: A Novel Approach for Effective Gout Management on Wistar Rats”	11
Ciprofloxacin HCl-loaded Albumin Nanoparticles for the Treatment of Recurrent Urinary Tract Infections: Preparation, Optimization, and Evaluation of Antibacterial Activity	11
Enhancing the Entrapment Efficiency of Alginate Floating Beads Using Double Emulsion Technique	10
Box–Behnken Design-Based Optimized Kinetic Approach to Develop an Eco-friendly Analytical Method for the Quantitation of Glimepiride Using Spectrophotometry	10
Implementing Quality by Design for Development and Optimization of Sublingual Tablet of Valsartan	10
Influence of Nanocarrier Type on the Drug Delivery Aspects of Docetaxel: Empirical Evidences	10

Promising Alginate-Gelatin Scaffolds Containing 5-Fluorouracil and Reinforced with Zinc-Modified Hydroxyapatite: Cell Attachment and One-Year Stability Study	10
Formulation of Mixed Micelles of Various Model Drug Ionic Complexes in an Optimized Micellar Base Composed of Surfactants and Cosolvent Mixture: In Vitro Analysis of Drug Delivery Efficiency	10
Synthesis, Structural Characterization, and Antimicrobial Evaluation of Silver Nanoparticle-embedded Layered Double Hydroxides for Delivery in Polymeric Hydrogel Matrices	10
DoE-Based Solid Self-microemulsifying Drug Delivery System (S-SMEDDS) Approach for Improving the Dissolution Properties of Raltegravir Potassium	9
Application of Artificial Intelligence in Identifying Human Immunoglobulin and Albumin in Commercial Intravenous Drugs	9
Investigation of In Vivo Bioavailability Enhancement of Iloperidone-Loaded Solid Self-Nanoemulsifying Drug Delivery Systems: Formulation and Optimization Using Box-Behnken Design and Desirability Func	9
A Comparative Investment Analysis of Batch Versus Continuous Pharmaceutical Manufacturing Technologies	9
Evaluation and Monitoring of the API Content of a Portable Near Infrared Instrument Combined with Chemometrics Based on Fluidized Bed Mixing Process	9
Preparation and Characterization of Gatifloxacin-Loaded Polyacrylonitrile Nanofiber for the Management of Dry Eye Infection	9
Assessment of the HaLCon® Protein Analyzer for At-Line Titer Measurements in Biomanufacturing Applications	8
Determination of Mixing Efficiency in Various Laboratory-Scale Semi-Solid Formulation Techniques Through Computational Fluid Dynamics and Finite Volume Simulations	8
Elucidation of Tartaric Acid-Assisted Supersaturation Maintenance of Dipyridamole by Eudragit® E100	8
Loss-on-Drying Prediction for a Vibrated Fluidised Bed Dryer by Means of Mass and Energy Balances	8
Systematic Optimization of Solid Lipid Nanoparticles of Silybin for Improved Oral Drug Delivery by Box-Behnken Design: In Vitro and In Vivo Evaluations	8
Assessment of Imaging Flow Cytometry for the Simultaneous Discrimination of Protein Particles and Silicone Oil Droplets in Biologicals	8
Design and Development of Fluconazole-Loaded Nanocellulose-Eudragit Vaginal Drug Delivery System	7
A Dynamic Model for GMP Compliance and Regulatory Science	7
In Memoriam: Dr. Stephen Scypinski by Dr. Jim Drennen, Emeritus Editor-in-Chief	7
Bioinspired Chitosan-Based Patches Enriched With Lipid-Casein Nanocarriers: An Innovative Approach for Wound Management and Evaluation in a Rat Model	7
Editorial: September 2022, What’s Next?	7
Defining the Range of Calibration Burden: From Full Calibration to Calibration-Free	7
Spray Angle Measurement in Pharmaceutical Sprays: Correct Methodology and Common Pitfalls	7
Editorial: Big Changes for the Journal of Pharmaceutical Innovation… and It is All Good!	7
A Simple Approach to Preparation of Surfactant Nano-Micelles Loaded Drugs	7
Editorial: Biologics and Parenterals: Major Newsmakers	7
Development and Characterization of Viburnum opulus L. Extract-Loaded Orodispersible Films: Potential Route of Administration for Phytochemicals	7
A Novel Azathioprine Polysaccharide Nanoparticle Enhances the Efficacy of Systemic Lupus Erythematosus Therapy	7
Process Monitoring and Characterization for Extraction of Herbal Medicines Based on Proton (1H) Nuclear Magnetic Resonance Spectroscopy and Multivariate Batch Modeling: a Case Study	6
Formulation and Development of Posaconazole Loaded Controlled Release Nanosponge Topical Gel for the Treatment of Fungal Infection	6
Using of Oxygen Species in the Sterilization of Medical Equipment and Assessment of the Test Results	6
A Comprehensive Review of Current Perspectives on Novel Drug Delivery Systems and Approaches for Lung Cancer Management	6
Correction to: The Reform of the Orphan Drug Assessment System in China	6
Application of Analytical Hierarchy Process to the Selection Suitability of Biological Drug forms for Psoriasis Treatment	6
The Evolution of Turbocharged Cancer Therapeutics - How Regulatory Flexibility has Driven Accelerated Cancer Biologics Approvals in the United States (1993–2023)	6
Novel Chitosan Beeswax Matrix for Gastro-Retentive Delivery of Curcumin: A Promising Adjuvant Therapy for Helicobacter Infection	6
Development and Assessment of Electrospun Nanofibrous Wound Dressing Containing Curcumin and Wedelolactone	6
Fusidic Acid Microemulsion Based on a Pseudoternary Phase Diagram: Development, Characterization, and Evaluation	6
Optimization, Formulation, and Stability of Topical Rapamycin Used for Rare Tuberous Sclerosis Disease: from Ointment to Liposomes	6
Mucoadhesive (Type-I) and Floating (Type-II) Chitosan Beads for Improved Gastric Retention of Clarithromycin	6
Preparation of Chitosan-Tripolyphosphate Formulated Insulin Microparticles, Their Characterization, ANN Prediction, and Release Kinetics	6
Thiocolchicoside Niosomal Gel: Design-Driven Optimization for Superior Skin Permeation	6
Optimizing Continuous Feeding of Poorly Flowing Excipients: Impact of Batch-To-Batch Variability and Process Design	5
Editorial: Innovation Accelerates into the Future	5
Fluconazole-Niosome-Laden Contact Lens: A Promising Therapeutic Approach for Prolonged Ocular Delivery and Enhanced Antifungal Activity	5
Comparative Study of Methods for the Pharmaceutical Preparation and Effectiveness of Darunavir Ethanolate Compositions with Mesoporous Carriers and Polymer Solid Dispersions	5
Prospects and Analysis of Traditional Chinese Medicine Standards Through the Transition of Chinese Pharmacopeia	5
Development and Optimization of Curcumin-Loaded Citric Acid Functionalized Multi-Walled Carbon Nanotubes for Enhanced Breast Cancer Treatment Using Design of Experiment	5
An Integrated Computational and Experimental Framework for Investigating Flavonoid-driven Bioenhancement of Curcumin	5
Continuous and Size-Controlled Preparation of Ibuprofen Nanosuspension by Antisolvent Crystallization Method Using Hollow Fiber Membrane	5
Ocular Delivery of Itraconazole Loaded Leciplex to Treat Fungal Infection	5

Physicochemical Characterization of Three Active Pharmaceutical Ingredients for Compound Glycyrrhizin Solid Formulation and Compatibility Analysis via Thermal and Non-thermal Techniques	5
“Implementation of Quality by Design of Sublingual Antihypertensive Drugs"	5
A Review on Solid Microneedles for Biomedical Applications	5
Rapid Determination in the Quality Control of Chinese Patent Medicine	5
Good Laboratory Practice in Preclinical Research: Lessons Learned from Warning Letters Issued Between 2019 and 2024 Addressing Violations to the 21 Code of Federal Regulation Part 58	5
Development, Optimization and In Vitro Characterization of Eudragit-Ganciclovir Nanosuspension or Treating Herpes Simplex Keratitis	4
Protection of Mucous Membranes Against the Use of Biocides	4
Design of a Pharmaceutical 3D Printer Using Quality-by-Design Approach	4
The Assessment of Vaginal permeability – in silico Approach	4
Effect of Manufacturing Conditions on Particle Characteristics in the Drug-Layering Process of a Novel Melt Granulation Technology, MALCORE®, Using a Design of Experiments	4
Formulation and Evaluation of Raloxifene Hydrochloride Co-Crystals with Bioenhancer – a Potential Approach for Solubility and Bioavailability Enhancement	4
Development and Evaluation of Carvedilol Nanosuspension by Acid Base Neutralization Method	4
Biosynthesis and Characterization of Silver Nanoparticle by Using Artocarpus altilis Fruit Extract for Its Biological Activity	4
Improving the Intestinal Permeability of Aprepitant via Self-Microemulsifying Delivery System: In Vitro Development and in Situ Permeation Assessment	4
Development of Paediatric Formulation of Baclofen for Improved Safety and Palatability	4
Screening of Polysaccharide Films Consisting of pH-Dependent Systems in Combination with Microbial Decomposition-Dependent Systems to Determine the Appropriate Coating for Colonic Drug Delivery	4
Preparation and Transformation of Solid Glass Solutions of Clotrimazole to Nanosuspensions with Improved Physicochemical and Antifungal Properties	4
Quality by Design (QbD) Enabled and Central-Composite Design Assisted Approach for Formulation of Oral Herbal Gastro-retentive In-situ Gel	4
Chronotherapeutic Delivery of Lornoxicam Pellets for Rheumatoid Arthritis: Formulation Development and Optimization Using a Randomized Factorial Design	4
Development and Pharmacokinetic Evaluation of Binary Carrier-Based Solid Dispersion of Desidustat, a New Drug for Chronic Kidney Disease-Associated Anemia	4
Formulate Lornoxicam Bio Adhesive Microspheres Using Different Polymers by Ionotropic Gelation Method and Emulsion Cross Linking Method: An Integrated Molecular Dynamics Approach	4
Salep Polysaccharide-Based Multi-Responsive Nanogel for Controlled Doxorubicin Release: Structural Characterization and Functional Evaluation for Targeted Breast Cancer Therapy	4
Formulation, Characterization, Optimization, and Pharmacokinetic Evaluation of Cilnidipine-Loaded Liquisolid Compacts with Improved Dissolution and Bioavailability	4
Nanosized Intranasal Delivery of Novel Self-Assembled Cubic Liquid Crystals: Formulation and Evaluation	4
FDA Warning Letters: A Retrospective Analysis of Letters Issued to Pharmaceutical Companies from 2010–2020	4
Green Synthesis of Silver Nanoparticles by Using Anthemis Tricolor Boiss., Factorial Design for Parameter Optimization, Characterization and In-Vitro Biological Activities	4
QbD Enabled Formulation Development of Nanoemulsion of Nimodipine for Improved Biopharmaceutical Performance	4
3D Drug Printing by Semi-Solid Extrusion Through Reusable Cartridges: Usability Evaluation	4
Ensuring Product Safety: A Comprehensive Retrospective Study of USFDA Drug Recalls (2019–2023)	3
Investigating the Effect of Particle Size on Cellular Uptake by Aggregation-Caused Quenching Probe–Encapsulating Solid Lipid Nanoparticles, Inhaled	3
Gossypol-Embedded Casein Nanoparticles for Potential Targeting of Ovarian Cancer: Formulation, Characterization, and Anticancer Activity	3
Deep Eutectic System-Based Liquisolid Nanoparticles as Drug Delivery System of Curcumin for In-Vitro Colon Cancer Cells	3
Preparation and In-Vitro Evaluation of Thermosensitive In-Situ Gel with Different Concentrations of Levofloxacin for Periodontal Applications	3
Design and Critical Characterization the Pharmaceutical Cocrystal of Azelnidipine With Coformers for Boosting Physicochemical Properties	3
Quality-by-Design Approach for Optimization and Processing of PLGA Polymer Film by Hot Melt Extrusion	3
Melt Granulation Techniques as an Alternative Manufacturing Technology for the Generic Development of Apixaban 5 mg Immediate-Release Tablets: A Case Study	3
Cardiovascular Drugs: an Insight of In Silico Drug Design Tools	3
Design of Abuse-Deterrent Formulations Using Various Types of Thermal Deformed Starch (TDS)	3
Predicting Skin Permeability of Compounds with Elasticnet, Ridge and Decision Tree Regression Methods	3
Bioactive Extract Production from Citrullus Clocynthis Fruit via Microwave-Assisted Extraction: Experimental Optimization, Process Design and Economics with Uncertainty Quantification	3
Novel Glyceryl Monostearate- and Polyethylene Glycol 6000-Based Ibuprofen Pellets Prepared by Hot-Melt Extrusion: Evaluation and Stability Assessment	3
Development of Chitosan-Based Microencapsulation System for Mitragyna speciosa Alkaloids: A Novel Approach for Alzheimer’s Disease Treatment	3
Statistical Formulation Optimization of Naproxen Microsponges with Eudragit RS100 for Sustained Drug Release	3
Development and In-Vitro Characterization of Capsaicin Microsponges Loaded Topical Gels for Management of Arthritis	3
New Insight into Acidifier-Induced Enhancement of Dissolution of Weakly Basic Drug, Dipyridamole	3
Enhancement of Valsartan Dissolution Rate by the Increased Porosity of Pellets Using Supercritical CO2: Optimization via Central Composite Design	3
Innovative Polymeric Micelles with In-Situ Gelation for Enhanced Ocular Delivery of Ketoconazole	3
Preparation of Stable Clindamycin Phosphate Niosomes by Combination of Sorbitan Esters and their Ethoxylaed Derivatives	3
A Communication Effectiveness Study of the FDA GMP Warning Letters	3
Has the Establishment of a FTZ Promoted the High-quality Development of the Pharmaceutical Manufacturing Industry?——Quasi Natural Experiments Based on the Establishment of the First Three Batches of P	3
Development and Optimization of a Self-Nanoemulsifying Drug Delivery System (SNEDDS) for Enhanced Oral Delivery of Dolutegravir	3
Unveiling the Pharmacological Mechanism of Cosmos Caudatus Compounds as Lung Cancer Drug Candidates: Pharmacology Networking, Molecular Docking, and Experimental Validation	3
Identification and Predictive Analysis of Revenue Determinants in the Pharma Industry: A Longitudinal Analysis of Financial, Regulatory and Pipeline Data	3
Formulation, Optimization, and In Vitro Studies of Roasted Agung Banana var. Semeru Peel Effervescent Antidepressant Tablet	3
Studies in Development and Statistical Optimization of Levofloxacin Solid Lipid Nanoparticles for the Treatment of Tuberculosis	3
Design, Optimization, and Characterization of Lysozyme-Loaded Poly(ɛ-Caprolactone) Microparticles for Pulmonary Delivery	3
Blockchain for Data Originality in Pharma Manufacturing	3
Fabrication and Characterisation of Taste-Masked Orally Dissolving Films Containing Ondansetron Hydrochloride Using Novel Poly(Amide-Thioester) Nanocapsules Based on L-Cysteine Amino-Acid	3
Design of a Production Planning System in a Pharmaceutical Factory: Spreadsheet Model and Case Study	3
Design and Evaluation of the PLGA Nanoparticles Containing Ketorolac Tromethamine in Glioblastoma Treatment	3