OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Cell Communication and Signaling is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
	79
ROR2 promotes epithelial-mesenchymal transition by hyperactivating ERK in melanoma	74
JAK3/STAT5 signaling‐triggered upregulation of PIK3CD contributes to gastric carcinoma development	72
Elevated reactive aggression in forebrain‐specific Ccn2 knockout mice	48
Targeting CCN2 protects against progressive non-alcoholic steatohepatitis in a preclinical model induced by high-fat feeding and type 2 diabetes	47
Stepping into the role of Editor‐in‐Chief of the Journal of Cell Communication and Signaling	44
Role of the calcium‐sensing receptor in regulating vascular function	39
A comprehensive network map of IL-17A signaling pathway	35
Cell–cell communications: new insights into targeting efficacy of phytochemical adjuvants on tight junctions and pathophysiology of various malignancies	34
METTL3–METTL14 complex induces necroptosis and inflammation of vascular smooth muscle cells via promoting N6 methyladenosine mRNA methylation of receptor-interacting protein 3 in abdominal aortic aneu	30
BMP4 enhances anoikis resistance and chemoresistance of breast cancer cells through canonical BMP signaling	28
Chemokine signaling in cancer-stroma communications	25
	25
Mitochondrial transcription factor B1 promotes the progression of hepatocellular carcinoma via enhancing aerobic glycolysis	21
Novel peptide—based inhibitor for targeted inhibition of T cell function	20
The antitumor effects of WNT5A against hematological malignancies	20
Tsukushi is essential for the formation of the posterior semicircular canal that detects gait performance	19
Three generations of mTOR kinase inhibitors in the activation of the apoptosis process in melanoma cells	18
Prediction of cellular targets in diabetic kidney diseases with single-cell transcriptomic analysis of db/db mouse kidneys	17
CD99 contributes to the EWS::FLI1 transcriptome by specifically affecting FOXM1‐targets involved in the G2/M cell cycle phase, thus influencing the Ewing sarcoma genetic landscape	17
Scutellarin alleviates microglia‐mediated neuroinflammation and apoptosis after ischemic stroke through the PI3K/AKT/GSK3β signaling pathway	16
METTL13 facilitates cell growth and metastasis in gastric cancer via an eEF1A/HN1L positive feedback circuit	16
Hepatitis B virus x gene-downregulated growth-arrest specific 5 inhibits the cell viability and invasion of hepatocellular carcinoma cell lines by activating Y-box-binding protein 1/p21 signaling	16
Adipocyte enhancer binding protein 1 knockdown alleviates osteoarthritis through inhibiting NF‐κB signaling pathway‐mediated inflammation and extracellular matrix degradation	16
Role of EGFR and FASN in breast cancer progression	15

Tools used to assay genomic instability in cancers and cancer meiomitosis	15
ELAVL1 promotes ferroptosis via the TRIM21/HOXD8 axis to inhibit osteogenic differentiation in congenital pseudoarticular tibia‐derived mesenchymal stem cells	15
The regulation and functions of the matricellular CCN proteins induced by shear stress	15
Dual RNase activity of IRE1 as a target for anticancer therapies	14
Advances in studies of circulating microRNAs: origination, transportation, and distal target regulation	14
CCN1 is predominantly elevated in human skin dermis by solar-simulated ultraviolet irradiation and accumulated in dermal extracellular matrix	13
Survival-based bioinformatics analysis to identify hub long non-coding RNAs along with lncRNA-miRNA-mRNA network for potential diagnosis/prognosis of thyroid cancer	13
The 12th international workshop on the CCN family of genes in pictures	13
Lipin-1 stability and its adipogenesis functions are regulated in contrasting ways by AKT1 and LKB1	13
TM4SF1 is a molecular facilitator that distributes cargo proteins intracellularly in endothelial cells in support of blood vessel formation	12
Lupeol and Paclitaxel cooperate in hindering hypoxia induced vasculogenic mimicry via suppression of HIF-1α-EphA2-Laminin-5γ2 network in human oral cancer	12
Reduced expression of Collagen 17A1 in naturally aged, photoaged, and UV-irradiated human skin in vivo: Potential links to epidermal aging	11
Farewell Springer… Hello Wiley	11
Insights into the mediation of Ca2+ signaling in the promoting effects of LETX-VI on the synthesis and release of dopamine	11
The network map of urotensin-II mediated signaling pathway in physiological and pathological conditions	11
Cellular crosstalk of glomerular endothelial cells and podocytes in diabetic kidney disease	11
Gastrokine 1 transferred by gastric cancer exosomes inhibits growth and invasion of gastric cancer cells in vitro and in vivo	11
Dysregulation of Notch-FGF signaling axis in germ cells results in cystic dilation of the rete testis in mice	10
miRNAs as short non-coding RNAs in regulating doxorubicin resistance	10
Daphnetin alleviates inflammation and promotes autophagy via the AMPK/mTOR pathway in gouty arthritis	10
Role of interleukin-6-mediated inflammation in the pathogenesis of inflammatory bowel disease: focus on the available therapeutic approaches and gut microbiome	10
The cryptic role of CXCL17/CXCR8 axis in the pathogenesis of cancers: a review of the latest evidence	10
Sustained AWT1 expression by Dupuytren’s disease myofibroblasts promotes a proinflammatory milieu	10
POSTN knockdown suppresses IL‐1β‐induced inflammation and apoptosis of nucleus pulposus cells via inhibiting the NF‐κB pathway and alleviates intervertebral disc degeneration	10
A review on Tsukushi: mammalian development, disorders, and therapy	10
Modeling the microenvironment special issue	10
Structural insights into regulation of CCN protein activities and functions	10
The power of combined spatial transcriptomics and genome wide association studies (GWAS) approaches to heritable prostate cancer	10
A review of non-prostanoid, eicosanoid receptors: expression, characterization, regulation, and mechanism of action	10
Identification of ZMYND19 as a novel biomarker of colorectal cancer: RNA-sequencing and machine learning analysis	10
Opioid receptors signaling network	9
Quinacrine inhibits cMET-mediated metastasis and angiogenesis in breast cancer stem cells	9
GSKIP modulates cell aggregation through EMT/MET signaling rather than differentiation in SH-SY5Y human neuroblastoma cells	9
Cellular communication network factor 3 in cartilage development and maintenance	9
Optimized multiplex immunofluorescence for the characterization of tumor immune microenvironment in neoplastic paraffin-preserved tissues	9
Quinacrine and Curcumin in combination decreased the breast cancer angiogenesis by modulating ABCG2 via VEGF A	9
Knockdown of Yap attenuates TAA-induced hepatic fibrosis by interaction with hedgehog signals	9
ACK1 upregulated the proliferation of head and neck squamous cell carcinoma cells by promoting p27 phosphorylation and degradation	8
SHP2 regulates adipose maintenance and adipocyte-pancreatic cancer cell crosstalk via PDHA1	8
Multiple G-quadruplex binding ligand induced transcriptomic map of cancer cell lines	7
Report on the 12th international workshop on the CCN family of genes, Oslo, June 20–23, 2024	7
The miR-302c/transforming growth factor-β receptor type-2 axis modulates interleukin-1β-induced degenerative changes in osteoarthritic chondrocytes	7
Evaluation of altered cell–cell communication between glia and neurons in the hippocampus of 3xTg‐AD mice at two time points	7
The small molecule peptide ANXA114‐26 inhibits ovarian cancer cell proliferation and reverses cisplatin resistance by binding to the formyl peptide receptors receptor	7
Critical role of mitogen-inducible gene 6 in restraining endothelial cell permeability to maintain vascular homeostasis	7
Survivin inhibition ameliorates liver fibrosis by inducing hepatic stellate cell senescence and depleting hepatic macrophage population	7
Macrophages‐derived small extracellular vesicles regulate chondrocyte proliferation and affect osteoarthritis progression via upregulating Osteopontin expression	7
The signaling pathways in obesity‐related complications	6
Role for the PIP₂‐binding protein myristoylated alanine‐rich C‐kinase substrate in vascular tissue: A novel therapeutic target for cardiovascular disease	6
Metformin combined with rapamycin ameliorates podocyte injury in idiopathic membranous nephropathy through the AMPK/mTOR signaling pathway	6

The functions of Ca2+/calmodulin-dependent protein kinase II (CaMKII) in diabetes progression	6
The advance of CCN3 in fibrosis	6
A multi-cellular molecular signaling and functional network map of C–C motif chemokine ligand 18 (CCL18): a chemokine with immunosuppressive and pro-tumor functions	6
Catalpol inhibits hepatic stellate cell activation by reducing the formation and changing the contents of hepatocyte-derived extracellular vesicles	6
A modular map of Bradykinin-mediated inflammatory signaling network	6
Matricellular proteins: Potential biomarkers in head and neck cancer	6
Overexpressed miR‐486 in bone marrow mesenchymal stem cells represses urethral fibrosis and targets Col13a1 in urethral stricture rats	5
The network map of Elabela signaling pathway in physiological and pathological conditions	5
Integrin α11β1 in tumor fibrosis: more than just another cancer-associated fibroblast biomarker?	5
tRNA-derived fragments (tRFs) in cancer	5
PKCι induces differential phosphorylation of STAT3 to modify STAT3-related signaling pathways in pancreatic cancer cells	5
The CCN2/CTGF interactome: an approach to understanding the versatility of CCN2/CTGF molecular activities	5
Biological functions of CRTC2 and its role in metabolism-related diseases	5
Spermatozoa, acts as an external cue and alters the cargo and production of the extracellular vesicles derived from oviductal epithelial cells in vitro	5
Correction to: Critical role of mitogen-inducible gene 6 in restraining endothelial cell permeability to maintain vascular homeostasis	5
Ephrin–Eph receptor tyrosine kinases for potential therapeutics against hepatic pathologies	5
Cellular communication network 1 promotes CASP2 mRNA expression but suppresses its protein translation in esophageal adenocarcinoma	5
A network map of macrophage-stimulating protein (MSP) signaling	4
Role of TLRs in EGFR-mediated IL-8 secretion by enteroaggregative Escherichia coli-infected cultured human intestinal epithelial cells	4
Protease-activated receptor 2 attenuates doxorubicin-induced apoptosis in colon cancer cells	4
Tert‐butyl hydroperoxide induces trabecular meshwork cells injury through ferroptotic cell death	4
Hsa_circ_0000515 sequesters microRNA‐296‐5p and elevates RNF44 expression to encourage the NSCLC progression	4
Endometriosis‐derived exosomes encapsulated miR‐196a‐5p mediate macrophage polarization through regulation of the Hippo pathway	4
Recent progress on the role of cellular communication network factors (CCN) 3, 4 and 6 in regulating adiposity, liver fibrosis and pancreatic islets	4
Temporal phosphoproteomic analysis of VEGF-A signaling in HUVECs: an insight into early signaling events associated with angiogenesis	4
CCNs and other extracellular matrix proteins: an introduction to the special issue	4
Retraction: A network map of cytoskeleton‐associated protein 4 (CKAP4) mediated signaling pathway in cancer	4
Skin aging from the perspective of dermal fibroblasts: the interplay between the adaptation to the extracellular matrix microenvironment and cell autonomous processes	4
Mutant p53 gain-of-function stimulates canonical Wnt signaling via PI3K/AKT pathway in colon cancer	4
The case of Connective Tissue Growth Factor (CTGF) and the pit of misleading and improper nomenclatures	4
CCN–Hippo YAP signaling in vision and its role in neuronal, glial and vascular cell function and behavior	4
Is the mechanism of COVID-19 coagulopathy still a rabbit’s hole?	4
Estrogens drive the endoplasmic reticulum-associated degradation and promote proto-oncogene c-Myc expression in prostate cancer cells by androgen receptor/estrogen receptor signaling	4
Atypical activation of signaling downstream of inactivated Bcr-Abl mediates chemoresistance in chronic myeloid leukemia	4
Use and application of organ-on-a-chip platforms in cancer research	4
CD47 interactions with exportin-1 limit the targeting of m7G-modified RNAs to extracellular vesicles	4
	4
Enoyl coenzyme a hydratase 1 attenuates aortic valve calcification by suppressing Runx2 via Wnt5a/Ca²⁺ pathway	4
A molecular network map of orexin-orexin receptor signaling system	4
Role for CCN1 in lysophosphatidic acid response in PC‐3 human prostate cancer cells	4
Lysine demethylase 5A promotes prostate adenocarcinoma progression by suppressing microRNA-330-3p expression and activating the COPB2/PI3K/AKT axis in an ETS1-dependent manner	3
Tissue distribution and transcriptional regulation of CCN5 in the heart after myocardial infarction	3
Renal FGF23 signaling depends on redox protein Memo1 and promotes orthovanadate-sensitive protein phosphotyrosyl phosphatase activity	3
Long non-coding RNA SOS1-IT1 promotes endometrial cancer progression by regulating hypoxia signaling pathway	3
The opposite effect of ELP4 and ZEB2 on TCF7L2‐mediated microglia polarization in ischemic stroke	3
Aneurysm severity is suppressed by deletion of CCN4	3
M2‐polarized tumor‐associated macrophage‐secreted exosomal lncRNA NEAT1 upregulates galectin‐3 by recruiting KLF5 and promotes HCC immune escape	3
Proteome‐wide assessment of human interactome as a source of capturing domain–motif and domain‐domain interactions	3
Emerging role of IRE1α in vascular diseases	3
SARS-CoV-2 signaling pathway map: A functional landscape of molecular mechanisms in COVID-19	3
Interleukin-1 alpha and high mobility group box-1 secretion in polyinosinic:polycytidylic-induced colorectal cancer cells occur via RIPK1-dependent mechanism and participate in tumourigenesis	3
The protective effects of phosphoserine aminotransferase 1 (PSAT1) against hepatic ischemia–reperfusion injury	3
Novel role of long non-coding RNAs in autoimmune cutaneous disease	3
Significance of CCNs in liver regeneration	3