OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Cell Communication and Signaling is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
	118
JAK3/STAT5 signaling‐triggered upregulation of PIK3CD contributes to gastric carcinoma development	71
Elevated reactive aggression in forebrain‐specific Ccn2 knockout mice	70
Targeting CCN2 protects against progressive non-alcoholic steatohepatitis in a preclinical model induced by high-fat feeding and type 2 diabetes	61
ROR2 promotes epithelial-mesenchymal transition by hyperactivating ERK in melanoma	39
Stepping into the role of Editor‐in‐Chief of the Journal of Cell Communication and Signaling	35
Cell–cell communications: new insights into targeting efficacy of phytochemical adjuvants on tight junctions and pathophysiology of various malignancies	31
Role of the calcium‐sensing receptor in regulating vascular function	29
Trans‐Coumaryl acetate mediates GRK5/NF‐κB/Nrf2 signaling axis to ameliorate septic acute kidney injury	28
A comprehensive network map of IL-17A signaling pathway	24
METTL3–METTL14 complex induces necroptosis and inflammation of vascular smooth muscle cells via promoting N6 methyladenosine mRNA methylation of receptor-interacting protein 3 in abdominal aortic aneu	23
The antitumor effects of WNT5A against hematological malignancies	22
	22
CD99 contributes to the EWS::FLI1 transcriptome by specifically affecting FOXM1‐targets involved in the G2/M cell cycle phase, thus influencing the Ewing sarcoma genetic landscape	21
Three generations of mTOR kinase inhibitors in the activation of the apoptosis process in melanoma cells	20
Adipocyte enhancer binding protein 1 knockdown alleviates osteoarthritis through inhibiting NF‐κB signaling pathway‐mediated inflammation and extracellular matrix degradation	19
METTL13 facilitates cell growth and metastasis in gastric cancer via an eEF1A/HN1L positive feedback circuit	19
Prediction of cellular targets in diabetic kidney diseases with single-cell transcriptomic analysis of db/db mouse kidneys	19
Scutellarin alleviates microglia‐mediated neuroinflammation and apoptosis after ischemic stroke through the PI3K/AKT/GSK3β signaling pathway	19
Dual RNase activity of IRE1 as a target for anticancer therapies	18
The regulation and functions of the matricellular CCN proteins induced by shear stress	18
ELAVL1 promotes ferroptosis via the TRIM21/HOXD8 axis to inhibit osteogenic differentiation in congenital pseudoarticular tibia‐derived mesenchymal stem cells	18
Role of EGFR and FASN in breast cancer progression	17
Lipin-1 stability and its adipogenesis functions are regulated in contrasting ways by AKT1 and LKB1	17
Advances in studies of circulating microRNAs: origination, transportation, and distal target regulation	17

The 12th international workshop on the CCN family of genes in pictures	17
Modulation of podocyte extracellular matrix remodeling in membranous nephropathy by the NFATc3/LRRC55/BK channel pathway	17
TM4SF1 is a molecular facilitator that distributes cargo proteins intracellularly in endothelial cells in support of blood vessel formation	16
Survival-based bioinformatics analysis to identify hub long non-coding RNAs along with lncRNA-miRNA-mRNA network for potential diagnosis/prognosis of thyroid cancer	15
Lupeol and Paclitaxel cooperate in hindering hypoxia induced vasculogenic mimicry via suppression of HIF-1α-EphA2-Laminin-5γ2 network in human oral cancer	15
Insights into the mediation of Ca2+ signaling in the promoting effects of LETX-VI on the synthesis and release of dopamine	14
Reduced expression of Collagen 17A1 in naturally aged, photoaged, and UV-irradiated human skin in vivo: Potential links to epidermal aging	14
Fat mass and obesity‐associated protein downregulation enhances N6‐methyladenosine methylation and drives ovarian cancer progression	14
CCN1 is predominantly elevated in human skin dermis by solar-simulated ultraviolet irradiation and accumulated in dermal extracellular matrix	14
Role of circ_0012856 in modulating molecular pathways of diabetic peripheral neuropathy	13
Cellular crosstalk of glomerular endothelial cells and podocytes in diabetic kidney disease	13
Gastrokine 1 transferred by gastric cancer exosomes inhibits growth and invasion of gastric cancer cells in vitro and in vivo	13
Farewell Springer… Hello Wiley	13
Notch NICD domains form biomolecular condensates	13
The network map of urotensin-II mediated signaling pathway in physiological and pathological conditions	12
Identification of ZMYND19 as a novel biomarker of colorectal cancer: RNA-sequencing and machine learning analysis	11
Structural insights into regulation of CCN protein activities and functions	11
A review on Tsukushi: mammalian development, disorders, and therapy	11
The structure, function, and distribution of gap junctions in the retina: Life cycle in health and disease	11
The power of combined spatial transcriptomics and genome wide association studies (GWAS) approaches to heritable prostate cancer	10
The cryptic role of CXCL17/CXCR8 axis in the pathogenesis of cancers: a review of the latest evidence	10
Role of interleukin-6-mediated inflammation in the pathogenesis of inflammatory bowel disease: focus on the available therapeutic approaches and gut microbiome	10
POSTN knockdown suppresses IL‐1β‐induced inflammation and apoptosis of nucleus pulposus cells via inhibiting the NF‐κB pathway and alleviates intervertebral disc degeneration	10
Daphnetin alleviates inflammation and promotes autophagy via the AMPK/mTOR pathway in gouty arthritis	10
miRNAs as short non-coding RNAs in regulating doxorubicin resistance	10
Quinacrine and Curcumin in combination decreased the breast cancer angiogenesis by modulating ABCG2 via VEGF A	10
Sustained AWT1 expression by Dupuytren’s disease myofibroblasts promotes a proinflammatory milieu	10
Modeling the microenvironment special issue	10
Critical role of mitogen-inducible gene 6 in restraining endothelial cell permeability to maintain vascular homeostasis	9
GSKIP modulates cell aggregation through EMT/MET signaling rather than differentiation in SH-SY5Y human neuroblastoma cells	9
Evaluation of altered cell–cell communication between glia and neurons in the hippocampus of 3xTg‐AD mice at two time points	8
Quinacrine inhibits cMET-mediated metastasis and angiogenesis in breast cancer stem cells	8
Survivin inhibition ameliorates liver fibrosis by inducing hepatic stellate cell senescence and depleting hepatic macrophage population	8
ACK1 upregulated the proliferation of head and neck squamous cell carcinoma cells by promoting p27 phosphorylation and degradation	8
Interaction between nuclear‐translocated cellular communication network factor 2 and purine‐rich box 1 regulates the expression of fibrosis‐related genes	8
Optimized multiplex immunofluorescence for the characterization of tumor immune microenvironment in neoplastic paraffin-preserved tissues	8
SHP2 regulates adipose maintenance and adipocyte-pancreatic cancer cell crosstalk via PDHA1	8
CD2–CD58 axis orchestrates cytotoxic T lymphocyte function and metabolic crosstalk in breast cancer brain metastasis	7
Macrophages‐derived small extracellular vesicles regulate chondrocyte proliferation and affect osteoarthritis progression via upregulating Osteopontin expression	7
Beyond the tumor: Enhancing pancreatic cancer therapy through glutamine metabolism and innovative drug delivery	7
The signaling pathways in obesity‐related complications	7
Report on the 12th international workshop on the CCN family of genes, Oslo, June 20–23, 2024	7
The small molecule peptide ANXA114‐26 inhibits ovarian cancer cell proliferation and reverses cisplatin resistance by binding to the formyl peptide receptors receptor	7
Ephrin–Eph receptor tyrosine kinases for potential therapeutics against hepatic pathologies	7
Knockdown of Yap attenuates TAA-induced hepatic fibrosis by interaction with hedgehog signals	7
Catalpol inhibits hepatic stellate cell activation by reducing the formation and changing the contents of hepatocyte-derived extracellular vesicles	7
The functions of Ca2+/calmodulin-dependent protein kinase II (CaMKII) in diabetes progression	7
Metformin combined with rapamycin ameliorates podocyte injury in idiopathic membranous nephropathy through the AMPK/mTOR signaling pathway	7
Cellular communication network 1 promotes CASP2 mRNA expression but suppresses its protein translation in esophageal adenocarcinoma	6
Role for the PIP₂‐binding protein myristoylated alanine‐rich C‐kinase substrate in vascular tissue: A novel therapeutic target for cardiovascular disease	6

Biological functions of CRTC2 and its role in metabolism-related diseases	6
Overexpressed miR‐486 in bone marrow mesenchymal stem cells represses urethral fibrosis and targets Col13a1 in urethral stricture rats	6
Correction to: Critical role of mitogen-inducible gene 6 in restraining endothelial cell permeability to maintain vascular homeostasis	6
The advance of CCN3 in fibrosis	6
Integrin α11β1 in tumor fibrosis: more than just another cancer-associated fibroblast biomarker?	6
PKCι induces differential phosphorylation of STAT3 to modify STAT3-related signaling pathways in pancreatic cancer cells	6
tRNA-derived fragments (tRFs) in cancer	6
Matricellular proteins: Potential biomarkers in head and neck cancer	6
CCN–Hippo YAP signaling in vision and its role in neuronal, glial and vascular cell function and behavior	5
Spermatozoa, acts as an external cue and alters the cargo and production of the extracellular vesicles derived from oviductal epithelial cells in vitro	5
Estrogens drive the endoplasmic reticulum-associated degradation and promote proto-oncogene c-Myc expression in prostate cancer cells by androgen receptor/estrogen receptor signaling	5
A molecular network map of orexin-orexin receptor signaling system	5
Temporal phosphoproteomic analysis of VEGF-A signaling in HUVECs: an insight into early signaling events associated with angiogenesis	5
A comprehensive analysis of the relationship between inflammasomes and autophagy in human tumors: Recent developments	5
A network map of macrophage-stimulating protein (MSP) signaling	5
	5
Pan‐cancer analysis and oncogenic implications of MGAM and MGAM2: Toward precision oncology and drug repurposing in colorectal cancer	5
CCNs and other extracellular matrix proteins: an introduction to the special issue	5
Recent progress on the role of cellular communication network factors (CCN) 3, 4 and 6 in regulating adiposity, liver fibrosis and pancreatic islets	5
The role of vitamin D receptor signaling in hair follicle health and alopecia: Current understanding and therapeutic implications	5
Endometriosis‐derived exosomes encapsulated miR‐196a‐5p mediate macrophage polarization through regulation of the Hippo pathway	5
Hypoxic adipose‐derived stem cell exosomes as carriers of miR‐100‐5p to enhance angiogenesis and suppress inflammation in diabetic foot ulcers	5
Role for CCN1 in lysophosphatidic acid response in PC‐3 human prostate cancer cells	5
Enoyl coenzyme a hydratase 1 attenuates aortic valve calcification by suppressing Runx2 via Wnt5a/Ca²⁺ pathway	4
Tert‐butyl hydroperoxide induces trabecular meshwork cells injury through ferroptotic cell death	4
The case of Connective Tissue Growth Factor (CTGF) and the pit of misleading and improper nomenclatures	4
Targeting the PI3K/Akt/NF‐κB axis: Cluster of differentiation 5‐like‐mediated immunometabolic regulation of macrophage polarization in abdominal aortic aneurysm	4
Hsa_circ_0000515 sequesters microRNA‐296‐5p and elevates RNF44 expression to encourage the NSCLC progression	4
Retraction: A network map of cytoskeleton‐associated protein 4 (CKAP4) mediated signaling pathway in cancer	4
Unveiling the role of Jagged2 in hypoxic pulmonary arterial hypertension: A NOX2‐mediated pathway	4
Skin aging from the perspective of dermal fibroblasts: the interplay between the adaptation to the extracellular matrix microenvironment and cell autonomous processes	4
Naa10p impairs PGC‐1α/Pparγ2 interaction to inhibit mitochondrial protection in pancreatitis	4
Role of TLRs in EGFR-mediated IL-8 secretion by enteroaggregative Escherichia coli-infected cultured human intestinal epithelial cells	4
Mutant p53 gain-of-function stimulates canonical Wnt signaling via PI3K/AKT pathway in colon cancer	4
Lysine demethylase 5A promotes prostate adenocarcinoma progression by suppressing microRNA-330-3p expression and activating the COPB2/PI3K/AKT axis in an ETS1-dependent manner	4
Stent treatment improves cerebral microcirculatory disorder and blood–brain barrier function in internal carotid artery stenosis via intercellular adhesion molecule 1 modulation	3
M2‐polarized tumor‐associated macrophage‐secreted exosomal lncRNA NEAT1 upregulates galectin‐3 by recruiting KLF5 and promotes HCC immune escape	3
Significance of CCNs in liver regeneration	3
The protective effects of phosphoserine aminotransferase 1 (PSAT1) against hepatic ischemia–reperfusion injury	3
Gut microbiota‐derived trimethylamine‐N‐oxide inhibits SIRT1 to regulate SM22α‐mediated smooth muscle cell inflammation and promote atherosclerosis progression	3
Renal FGF23 signaling depends on redox protein Memo1 and promotes orthovanadate-sensitive protein phosphotyrosyl phosphatase activity	3
Celebrating milestones in cell communication and signaling: Forthcoming joint ICCNS–ARBIOCOM anniversary meeting	3
The opposite effect of ELP4 and ZEB2 on TCF7L2‐mediated microglia polarization in ischemic stroke	3
Use and application of organ-on-a-chip platforms in cancer research	3
Proteome‐wide assessment of human interactome as a source of capturing domain–motif and domain‐domain interactions	3
Interleukin-1 alpha and high mobility group box-1 secretion in polyinosinic:polycytidylic-induced colorectal cancer cells occur via RIPK1-dependent mechanism and participate in tumourigenesis	3
Leukocyte immunoglobulin‐like receptor B2 regulates atherosclerosis progression by modulating macrophage extracellular trap formation in foam macrophages through the PI3K‐AKT signaling pathway	3
Protease-activated receptor 2 attenuates doxorubicin-induced apoptosis in colon cancer cells	3