Current Molecular Pharmacology

Article	Citations
Targeting of Lysosomes as a Therapeutic Target in Cancer	72
Exploring Molecular Approaches in Amyotrophic Lateral Sclerosis: Drug Targets from Clinical and Pre-Clinical Findings	46
RNA Interference-based Therapies for the Reduction of Cardiovascular Risk	32
Pain Perception and Management: Where do We Stand?	29
Protective Effects of Antrodia cinnamomea and Its Constituent Compound Dehydroeburicoic Acid 32 Against Alcoholic Fatty Liver Disease	28
Deregulated MicroRNAs involved in P53 Signaling Pathway in Breast Cancer with Focus on Triple-negative Breast Cancer	27
Crocin Protects Against Beta-Amyloid Peptide-Induced Apoptosis in PC12 Cells Via the PI3 K Pathway	26
Quercetin Inhibits AQP1 Translocation in High-Glucose-Cultured SRA01/04 Cells Through PI3K/Akt/mTOR Pathway	26
Mutations in Rv0678, Rv2535c, and Rv1979c Confer Resistance to Bedaquiline in Clinical Isolates of Mycobacterium Tuberculosis	25
Dapagliflozin Protects H9c2 Cells Against Injury Induced by Lipopolysaccharide via Suppression of CX3CL1/CX3CR1 Axis and NF-κB Activity	24
Humanin Ameliorates Late-onset Hypogonadism in Aged Male Rats	24
Alzheimer’s Disease and other Tauopathies: Exploring Efficacy of Medicinal Plant-derived Compounds in Alleviating Tau-mediated Neurodegeneration	23
Chimeric Antigen Receptor T-cells (CARs) in Cancer Treatment	23
Obesity and Inflammation: Colorectal Cancer Engines	23
Quercetin in Attenuation of Ischemic/Reperfusion Injury: A Review	22
Recombinant Human Regenerating Gene 4 Attenuates the Severity of Osteoarthritis by Promoting the Proliferation of Articular Chondrocyte in an Animal Model	21
Effects of Modafinil (Provigil) on Memory and Learning in Experimental and Clinical Studies: From Molecular Mechanisms to Behaviour Molecular Mechanisms and Behavioural Effects	20
Anticancer Properties of Baicalin against Breast Cancer and other Gynecological Cancers: Therapeutic Opportunities based on Underlying Mechanisms	19
A Deeply Quiescent Subset of CML LSC depend on FAO yet Avoid Deleterious ROS by Suppressing Mitochondrial Complex I	19
Cytotoxic and Antitumoral Activity of N-(9H-purin-6-yl) Benzamide Derivatives and Related Water-soluble Prodrugs	19
Epigenetic Evaluation of N-(2-hydroxyphenyl)-2-Propylpentanamide, a Valproic Acid Aryl Derivative with Activity Against HeLa Cells	18
Grp94 Inhibitor HCP1 Suppressed the Replication of SVA in BHK-21 Cells and PK-15 Cells	16
Mechanism, Potential, and Concerns of Immunotherapy for Hepatocellular Carcinoma and Liver Transplantation	16
Carvacrol as a Prospective Regulator of Cancer Targets/Signalling Pathways	15
Adipose Tissue Dysfunction Following Trauma and Hypoxia Increases the Risk of Post-Surgical Adhesion: Potential for Therapeutic Interventions	15

Effect of Lapachol on the Inhibition of Matrix Metalloproteinase Related to the Invasion of Human Fibrosarcoma Cells	15
Promising Anticancer Activity of Multitarget Cyclin Dependent Kinase Inhibitors against Human Colorectal Carcinoma Cells	15
Targeting FGFR3 is a Useful Therapeutic Strategy for Rheumatoid Arthritis Treatment	15
Cryptotanshinone Induces Necroptosis Through Ca2+ Release and ROS Production in vitro and in vivo	14
The Involvement of the NEAT1-1/miR-873-5p/GalNAcT-I Axis in the Development of Neuroblastoma	14
Assessment of Antioxidant Effect of Beta-Glucan on the Whole Blood Oxidative DNA Damage with the Comet Assay in Colorectal Cancer	14
Exploring the Immune-Related Molecular Mechanisms Underlying the Comorbidity of Temporal Lobe Epilepsy and Major Depressive Disorder through Integrated Data Set Analysis	14
BAPST. A Combo of Common Use Drugs as Metabolic Therapy for Cancer: A Theoretical Proposal	13
PIASA, A Novel Peptide, Prevents SH-SY5Y Neuroblastoma Cells against Rotenone-induced Toxicity	13
A Review of the Dual Role of MicroRNA-21 in Cardiovascular Diseases: Risk Factor or a Potential Therapeutic Target	13
SK1 Inhibitor RB005 Induces Apoptosis in Colorectal Cancer Cells through SK1 Inhibition Dependent and Independent Pathway	13
Prevalence of Hepatocellular Carcinoma in Men and the Contribution of Androgen and its Receptor in Pathogenesis and Therapy	13
Protective Effect of Chrysin against Chlorpyrifos-Induced Metabolic Impairment and Pancreatitis in Male Rats	12
The Treatment of Parkinson’s Disease with Sodium Oxybate	12
BBOX1-AS1 Activates Hedgehog Signaling Pathway to Facilitate the Proliferation and Stemness of Esophageal Squamous Cell Carcinoma Cells via miR-506-5p/EIF5A/PTCH1 Axis	12
Dual Role of Pregnane X Receptor in Nonalcoholic Fatty Liver Disease	12
The Therapeutic Effect and Mechanism of Qishen Yiqi Dripping Pills on Cardiovascular and Cerebrovascular Diseases and Diabetic Complications	12
Ginger and Heart Health: From Mechanisms to Therapeutics	12
Novel Chalcone BDD-39 Mitigated Diabetic Nephropathy through the Activation of Nrf2/ARE Signaling	12
MiR-129-2-3p Inhibits Esophageal Carcinoma Cell Proliferation, Migration, and Invasion via Targeting DNMT3B	11
Anti-Cancer Role of Dendrosomal Nano Solanine in Chronic Myelogenous Leukemia Cell Line through Attenuation of PI3K/AKT/mTOR Signaling Pathway and Inhibition of hTERT Expression	11
Molecular Insight into the Apoptotic Mechanism of Cancer Cells: An Explicative Review	11
D-allose: Molecular Pathways and Therapeutic Capacity in Cancer	11
Tumor Organoid Model and Its Pharmacological Applications in Tumorigenesis Prevention	11
Sericic Acid Ameliorates DSS-induced Ulcerative Colitis in Mice by Modulating the NF-κB and Nrf2 Pathways	10
Upregulation of miR-3130-5p Enhances Hepatocellular Carcinoma Growth by Suppressing Ferredoxin 1 : miR-3130-5p Enhances HCC Growth via Inhibiting FDX1	10
Gentiopicroside Ameliorated Ductular Reaction and Inflammatory Response in DDC-induced Murine Cholangiopathies Model	10
Aloperine Alleviates Atherosclerosis by Inhibiting NLRP3 Inflammasome Activation in Macrophages and ApoE-/- Mice	10
An Essential Role of c-Fos in Notch1-mediated Promotion of Proliferation of KSHV-Infected SH-SY5Y Cells	10
Hypotensive Effects of the Triterpene Oleanolic Acid for Cardiovascular Prevention	9
DoE Based Optimization and Development of Spray-Dried Chitosan-Coated Alginate Microparticles Loaded with Cisplatin for the Treatment of Cervical Cancer	9
Thyroidectomy and PTU-Induced Hypothyroidism: Effect of L-Thyroxine on Suppression of Spatial and Non-Spatial Memory Related Signaling Molecules	9
Water Pipe Tobacco Smoking and Risk of Coronary Artery Disease: A Systematic Review and Meta-Analysis	9
Gut Microbiota Modulation for Therapeutic Management of Various Diseases: A New Perspective Using Stem Cell Therapy	9
Antinociceptive and Anti-Inflammatory Like Effects of Berberis baluchistanica	9
Natural Products and Cardiovascular Diseases	9
Fenbufen Alleviates Severe Acute Pancreatitis by Suppressing Caspase-1/Caspase-11-mediated Pyroptosis in Mice	9
Inhibitory Effects of Cathepsin K Inhibitor (ODN-MK-0822) on the Paracrine Pro-Osteoclast Factors of Breast Cancer Cells	9
Molecular Insights into Agonist/Antagonist Effects on Macromolecules Involved in Human Disease Mechanisms	8
Extracts from Artemisia annua Alleviates Myocardial Remodeling through TGF-β1/Smad2/3 Pathway and NLRP3 Inflammasome	8
PF-04449913 Inhibits Proliferation and Metastasis of Colorectal Cancer Cells by Down-regulating MMP9 Expression through the ERK/p65 Pathway	8
Ketamine Metabolites-waiting in the Wings as Therapeutic Candidate for Depression?	8
PCSK9 Biomarker and Key Modulator for Cardiovascular Disorders: Heralding a New Therapeutic Era and Their Future Perspectives	8
Evaluation of the Effect of Isobutyl Paraben and 2-ethyl Hexyl Paraben on P-glycoprotein Functional Expression in Rats: A Pharmacokinetic Study	8
Review of the Role of Metabolic Factors in Determining the Post-surgical Adhesion and its Therapeutic Implications, with a Focus on Extracellular Matrix and Oxidative Stress	8
Fenofibrate Inhibits LPS and Zymosan-induced Inflammatory Responses through Sonic Hedgehog in IMG Cells	8
Propitious Profile of Peppery Piperine	8
Reduction of Genotoxicity of Carbamazepine to Human Lymphocytes by Pre-treatment with Vitamin B12	8
Acknowledgements to Reviewers	7
Sanguinarine Attenuates Lung Cancer Progression via Oxidative Stress-induced Cell Apoptosis	7

A Comprehensive Review of Essential Aspects of Molecular Pathophysiological Mechanisms with Emerging Interventions for Sarcopenia in Older People	7
Preface	7
Upregulation of LncRNA WT1-AS Inhibits Tumor Growth and Promotes Autophagy in Gastric Cancer via Suppression of PI3K/Akt/mTOR Pathway	7
Nrf2 Mediates Effect of Resveratrol in Ischemia-reperfusion Injury	7
Effects of Mycotoxins on Child Development	7
Research Progress and Future Development Potential of Oridonin in Pharmacological Activities	7
RBM3 Accelerates Wound Healing of Skin in Diabetes through ERK1/2 Signaling	7
Influence of SGLT2 Inhibitors in Remodeling, Substrate and Ion Metabolism of Myocardium to Prevent Cardiovascular Risks: Recent Work and Advancement	6
Disruption of Wnt/β-catenin Pathway Elevates the Sensitivity of Gastric Cancer Cells to PD-1 Antibody	6
Neuroprotective Effects of Shogaol in Metals (Al, As and Pb) and High-fat diet-induced Neuroinflammation and Behavior in Mice	6
Protective Effects of Low Dose Vorinostat on Cisplatin-Induced Nephrotoxicity in Rats	6
Structural Understanding of SARS-CoV-2 Drug Targets, Active Site Contour Map Analysis and COVID-19 Therapeutics	6
Immunomodulatory Activity of Diterpenes over Innate Immunity and Cytokine Production in a Human Alveolar Epithelial Cell Line Infected with Mycobacterium tuberculosis	6
Depression-like Behavior Induced by Repeated Administration of Dexamethasone to Lipopolysaccharide-inflamed Mice	6
Retinoprotective Effects Of Crocin And Crocetin via Anti-Angiogenic Mechanism in High Glucose-Induced Human Retinal Pigment Epithelium Cells	6
Potential Therapeutic Strategies to Combat HCC	6
Anticancer Effects of Tacrolimus on Induced Hepatocellular Carcinoma in Mice	6
Maprotiline Prompts an Antitumour Effect by Inhibiting PD-L1 Expression in Mice with Melanoma	6
TRIM65 in White Matter Lesions, Innate Immunity, and Tumor	6
H3K4 Methylation Status and Lysine Specific Methyltransferase KMT2C Expression Correlate with Prognosis in Lung Adenocarcinoma	6
Bedaquiline in Drug-Resistant Tuberculosis: A Mini-Review	6
At the Crossroads of TNF α Signaling and Cancer	6
Renoprotective Effect of Thymoquinone against Streptozotocin-Induced Diabetic Nephropathy: Role of NOX2 and Nrf2 Signals	6
Development and Characterization of a Clobetasol Propionate Nanostructured Lipid Carrier-Based Gel for the Treatment of Plaque Psoriasis	6
Short-term Uridine Treatment Alleviates Endoplasmic Reticulum Stress via Regulating Inflammation and Oxidative Stress in Lithium-Pilocarpine Model of Status Epilepticus	6
A Review on Post-traumatic Stress Disorder (PTSD): Symptoms, Therapies and Recent Case Studies	6
Evaluation of Dual Inhibitory Effect of Anagliptin, Ramipril and Lisinopril on Angiotensin-Converting Enzyme and DPP-4 Activities	6
Epigenetic Regulation and Promising Therapies in Colorectal Cancer	6
Current Strategies for the Management of Psoriasis with Potential Pharmacological Pathways using Herbals and Immuno-biologicals	6
EGFR Inhibitor CL-387785 Suppresses the Progression of Lung Adenocarcinoma	6
Effect of Chrysin and Chrysin Nanocrystals on Chlorpyrifos-Induced Dysfunction of the Hypothalamic-Pituitary-Testicular Axis in Rats	5
Recent Advances in Herbal Nanomedicines for Cancer Treatment	5
Clozapine-induced Myocarditis: Pathophysiologic Mechanisms and Implications for Therapeutic Approaches	5
Combined Phloretin and Human Platelet-rich Plasma Effectively Preserved Integrities of Brain Structure and Neurological Function in Rat after Traumatic Brain Damage	5
Natural Products as PI3K/ Akt Inhibitors: Implications in Preventing Hepatocellular Carcinoma	5
Immunopharmacological Properties of VitD3: 1, 25VitD3 Modulates Regulatory T Cells and Th17 Cells and the Cytokine Balance in PBMCs from Women with Unexplained Recurrent Spontaneous Abortion (URSA)	5
Thwarting Coronavirus Infections by Tapping Host Targets: The ‘Greek Gift Sacrifice’ to Curb the Menace of Drug Resistances	5
Recent Advances in Vaginal Delivery for the Treatment of Vulvovaginal Candidiasis	5
A Proteomics Study of the Subacute Toxicity of Rat Brain after Long- Term Exposure of Gelsemium elegans	5
A Clinical Perspective of Soluble Epoxide Hydrolase Inhibitors in Metabolic and Related Cardiovascular Diseases	5
Hepatic Ischemia-reperfusion Injury: Protective Approaches and Treatment	5
The Effect of PAOPA, a Novel Allosteric Modulator of Dopamine D2 Receptors, on Signaling Proteins Following Sub-Chronic Administration in Rats	5
Pharmacotherapy for SARS-CoV-2 and Seizures for Drug Repurposing Presumed on Mechanistic Targets	5
Mitochondria-targeted Uncouplers Decrease Inflammatory Reactions in Endothelial Cells by Enhancing Methylation of the ICAM1 Gene Promoter	5
Neuropilin-2 Inhibits Drug Resistance and Progression of Melanoma Involving the MiR-331-3p Regulated Cascade	5
Scutellarin Mediates Cytochrome P450 3A4 and 2C19 Expression via Pregnane X Receptor and Constitutive Androstane Receptor	5
The Regulatory Mechanism of Hypoxia-inducible Factor 1 and its Clinical Significance	5
IDO2-siRNA Carried by Salmonella Combined with Nifuroxazide Attenuates Melanoma Growth	5
Comprehensive Analysis of SARS-COV-2 Drug Targets and Pharmacological Aspects in Treating the COVID-19	5
The Effects of Acute and Chronic Sleep Deprivation on the Immune Profile in the Rat	5
Toxicity, Genotoxicity, and Carcinogenicity of Isotretinoin	5
Polysaccharides to Combat Viruses (COVID-19) and Microbes: New updates	5
The Mechanistic Role of Thymoquinone in Parkinson's Disease: Focus on Neuroprotection in Pre-Clinical Studies	4
Impact of Nicosulfuron on Sperm Quality: Insights into Testicular Cell Apoptosis and NF-κB Signaling Pathway in Mice Testes	4
Anti-Diabetic Effects of Isolated Lipids from Natural Sources through Modulation of Angiogenesis	4
Combined Bazedoxifene and Genistein Ameliorate Ovariectomy-Induced Hippocampal Neuro-Alterations via Activating CREB/BDNF/TrkB Signaling Pathway	4
Effect of Edaravone on MicroRNA Expression in Exosomes after Hepatic Ischemia-reperfusion Injury	4
Cilia Plays a Pivotal Role in the Hypersecretion of Airway Mucus in Mice	4
The Struggle with Rheumatism through Dracunculus vulgaris Schott: In the Light of Ethnobotanical Information	4
Probing the Ubiquitination-Mediated Function of Epithelial Sodium Channel in A549 Cells	4
Ferulic Acid Attenuates Kainate-induced Neurodegeneration in a Rat Poststatus Epilepticus Model	4
Bovine lactoferrin as a Modulator of Neuroendocrine Components of Stress	4
Intrathecal Administration of Melatonin Ameliorates the Neuroinflammation- Mediated Sensory and Motor Dysfunction in A Rat Model of Compression Spinal Cord Injury	4
Hesperidin Exerts Anxiolytic-like Effects in Rats with Streptozotocin‐ Induced Diabetes via PKA/CREB Signaling	4
Molecular Mechanism of a Specific NLRP3 Inhibitor to Alleviate Seizure Severity Induced by Pentylenetetrazole	4
Dual Targeting of Autophagy and NF-κB Pathway by PPARγ Contributes to the Inhibitory Effect of Demethoxycurcumin on NLRP3 Inflammasome Priming	4
Hsa_Circ_0000021 Sponges miR-3940-3p/KPNA2 Expression to Promote Cervical Cancer Progression	4
Withdrawn: Variations in Altered Global Gene Expression caused by Topoisomerase II Poisons Assessed with Reference to Differences in DNA Binding	4
Thymoquinone Attenuates Retinal Expression of Mediators and Markers of Neurodegeneration in a Diabetic Animal Model	4
Moving Towards Dawn: KRas Signaling and Treatment in Pancreatic Ductal Adenocarcinoma	4
Chlorpyrifos with Age-Dependent Effects in Cardiac Tissue of Male Rats	4
The Role of Complement Component 3 (C3) in Psoriasis	4
Nanoparticulate Carriers for the treatment of Infectious Diseases and Cancer	4
Thioacetamide-Induced Norepinephrine Production by Hepatocytes is Associated with Hepatic Stellate Cell Activation and Liver Fibrosis	4
Ginkgolic Acids Confer Potential Anticancer Effects by Targeting Pro- Inflammatory and Oncogenic Signaling Molecules	3
Apelin Receptor Dimerization and Oligomerization	3
Inactivation of Parathyroid Hormone: Perspectives of Drug Discovery to Combating Hyperparathyroidism	3
Agomelatine: An Astounding Sui-generis Antidepressant?	3
Organoids: Current Implications and Pharmaceutical Applications in Liver Diseases	3
Neuroprotective Potential of Tanshinone-IIA in Mitigating Propionic Acidinduced Experimental Autism-like Behavioral and Neurochemical Alterations: Insights into c-JNK and p38MAPK Pathways	3

Preventive and Therapeutic Aspects of Migraine for Patient Care: An Insight	3
Natural Products, the Continuous Source of Therapeutic Molecules for Various Diseases: Literature Landscape Analysis	3
A Detailed Review of Molecular Pathways and Mechanisms Responsible for the Development and Aggravation of Neuropathy and Nephropathy in Diabetes	3
Curcumin Efficacy in a Serum/Glucose Deprivation-Induced Neuronal PC12 Injury Model	3
Empagliflozin Mitigates High Glucose-Disrupted Mitochondrial Respiratory Function in H9c2 Cardiomyoblasts: A Comparative Study with NHE-1 and ROCK Inhibition	3
State of the Art Molecular Pharmacology, Pathogenesis and Epigenetics of 3 Major Cancers: Lung Cancer, Ovarian Cancer, and Gliomas	3
Arsenic Exposure and Amyloid Precursor Protein Processing: A Focus on Alzheimer's Disease	3
PiWi RNA in Neurodevelopment and Neurodegenerative Disorders	3
Cytochrome bc1-aa3 Oxidase Supercomplex As Emerging and Potential Drug Target Against Tuberculosis	3
Hepatoprotective Effect of Myricetin following Lipopolysaccharide/DGalactosamine: Involvement of Autophagy and Sirtuin 1	3
Covid-19: Pathophysiology; Mechanism of Transmission and Possible Molecular Drug Target for Management	3
Mycotoxin Exposure and Autism: A Systematic Review of the Molecular Mechanism	3
SGLT-2 Inhibitors: Ideal Remedy for Cardioprotection in Diabetes Mellitus	3
Key miRNAs in Modulating Aging and Longevity: A Focus on Signaling Pathways and Cellular Targets	3
Amygdalin Decreases Adhesion and Migration of MDA-MB-231 and MCF-7 Breast Cancer Cell Lines	3
The Effect of Fingolimod on Renal Ischemia/Reperfusion Injury in a Rat Model	3
Guggulsterone Promotes Nasopharyngeal Carcinoma Cells Exosomal Circfip1L1 to Mediate miR-125a-5p/VEGFA Affecting Tumor Angiogenesis	3
Two GnRH-mitoxantrone Conjugates, Con-3 and Con-7, Target Endometrial Cancer Cells	3
Doxazosin Attenuates Development of Testosterone Propionate-induced Prostate Growth by regulating TGF-β/Smad Signaling Pathway, Prostate-specific Antigen Expression and Reversing Epithelial-Mesenchyma	3
Clinical Biomarkers and Novel Drug Targets to Cut Gordian Knots of Alzheimer's Disease	3
The Mediating Role of miR-451/ETV4/MMP13 Signaling Axis on Epithelialmesenchymal Transition in Promoting Non-small Cell Lung Cancer Progression	3