OOIR: Observatory of International Research

Papers

(The TQCC of Current Molecular Pharmacology is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Minocycline and Doxycycline: More Than Antibiotics	43
Melatonin Receptor as a Drug Target for Neuroprotection	31
Impact of Sitagliptin on Non-diabetic Covid-19 Patients	30
Hypoxia-Inducible Factor (HIF): Fuel for Cancer Progression	24
Oral Administration of the Food-Derived Hydrophilic Antioxidant Ergothioneine Enhances Object Recognition Memory in Mice	24
Bacterial Siderophores and Their Potential Applications: A Review	19
Connection between JAK/STAT and PPARγ Signaling During the Progression of Multiple Sclerosis: Insights into the Modulation of T-Cells and Immune Responses in the Brain	18
Polyphenols can Potentially Prevent Atherosclerosis and Cardiovascular Disease by Modulating Macrophage Cholesterol Metabolism	18
Molecular Mechanism of a Specific NLRP3 Inhibitor to Alleviate Seizure Severity Induced by Pentylenetetrazole	18
Recent Updates in the Alzheimer’s Disease Etiopathology and Possible Treatment Approaches: A Narrative Review of Current Clinical Trials	16
Nuezhenide Exerts Anti-Inflammatory Activity through the NF-κB Pathway	16
Alzheimer’s Disease and other Tauopathies: Exploring Efficacy of Medicinal Plant-derived Compounds in Alleviating Tau-mediated Neurodegeneration	16
FAT10: Function and Relationship with Cancer	15
Anticonvulsant, Anxiolytic and Antidepressant Properties of the β-caryophyllene in Swiss Mice: Involvement of Benzodiazepine-GABAAergic, Serotonergic and Nitrergic Systems	15
Statins Attenuate Fibrotic Manifestations of Cardiac Tissue Damage	14
Apelin/Apelin Receptor System: Molecular Characteristics, Physiological Roles, and Prospects as a Target for Disease Prevention and Pharmacotherapy	14
Polyphenols as Potential Therapeutics for Pain and Inflammation in Spinal Cord Injury	14
Salvia miltiorrhiza in Anti-diabetic Angiopathy	14
CircRNA 001418 Promoted Cell Growth and Metastasis of Bladder Carcinoma via EphA2 by miR-1297	14
Curcumin Efficacy in a Serum/Glucose Deprivation-Induced Neuronal PC12 Injury Model	13
Obesity and Inflammation: Colorectal Cancer Engines	13
Interleukin-19 as an Immunoregulatory Cytokine	13
Ginger and Heart Health: From Mechanisms to Therapeutics	13
Quercetin in Attenuation of Ischemic/Reperfusion Injury: A Review	13
Effects of Galbanic Acid on Proliferation, Migration, and Apoptosis of Glioblastoma Cells Through the PI3K/Akt/MTOR Signaling Pathway	13

Hepatic Stellate Cell: A Potential Target for Hepatocellular Carcinoma	13
Radio-Susceptibility of Nasopharyngeal Carcinoma: Focus on Epstein- Barr Virus, MicroRNAs, Long Non-Coding RNAs and Circular RNAs	12
Therapeutic Potential of Resveratrol in Diabetic Nephropathy According to Molecular Signaling	12
Intrathecal Administration of Melatonin Ameliorates the Neuroinflammation- Mediated Sensory and Motor Dysfunction in A Rat Model of Compression Spinal Cord Injury	11
Ticagrelor Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats by the Inhibition of TGF-β1/Smad3 and PI3K/AKT/mTOR Pathways	11
Drug Repurposing for Cancer Therapy in the Era of Precision Medicine	11
Recent Advances in Herbal Nanomedicines for Cancer Treatment	11
miR-18a-3p Encourages Apoptosis of Chondrocyte in Osteoarthritis via HOXA1 Pathway	11
Caveolin-1: A Promising Therapeutic Target for Diverse Diseases	11
The Impact of Royal Jelly against Hepatic Ischemia/Reperfusion-Induced Hepatocyte Damage in Rats: The Role of Cytoglobin, Nrf-2/HO-1/COX-4, and P38-MAPK/NF-κB-p65/TNF-α Signaling Pathways	10
Quinoa (Chenopodium quinoa Willd.): Exploring a Superfood from Andean Indigenous Cultures with Potential to Reduce Cardiovascular Disease (CVD) Risk Markers	10
A Review on Post-traumatic Stress Disorder (PTSD): Symptoms, Therapies and Recent Case Studies	10
Epigenetic Regulation and Promising Therapies in Colorectal Cancer	10
Daclatasvir and Sofosbuvir Mitigate Hepatic Fibrosis Through Downregulation of TNF-α / NF-κB Signaling Pathway	10
Valproic acid, A Potential Inducer of Osteogenesis in Mouse Mesenchymal Stem Cells	9
Alcoholic Neuropathy: Involvement of Multifaceted Signalling Mechanisms	9
Pain Perception and Management: Where do We Stand?	9
Recent Nanocarrier Approaches for Targeted Drug Delivery in Cancer Therapy	9
Novel Strategy in Breast Cancer Therapy: Revealing The Bright Side of Ginsenosides	9
Natural Products as PI3K/ Akt Inhibitors: Implications in Preventing Hepatocellular Carcinoma	9
The Beneficial Effect of Rice Bran Extract Against Rotenone-Induced Experimental Parkinson’s Disease in Rats	9
Quercetin Inhibits AQP1 Translocation in High-Glucose-Cultured SRA01/04 Cells Through PI3K/Akt/mTOR Pathway	9
Actions of Alcohol in Brain: Genetics, Metabolomics, GABA Receptors, Proteomics and Glutamate Transporter GLAST/EAAT1	9
Nf-κb: A Target for Synchronizing the Functioning Nervous Tissue Progenitors of Different Types in Alzheimer's Disease	8
Acetate Suppresses Lipopolysaccharide-stimulated Nitric Oxide Production in Primary Rat Microglia but not in BV-2 Microglia Cells	8
A Clinical Perspective of Soluble Epoxide Hydrolase Inhibitors in Metabolic and Related Cardiovascular Diseases	8
Possibility that the Onset of Autism Spectrum Disorder is Induced by Failure of the Glutamine-Glutamate Cycle	8
Flavonoids as Prospective Aromatase Inhibitors in Breast Cancer Prevention/ Therapy	8
Exploring Molecular Approaches in Amyotrophic Lateral Sclerosis: Drug Targets from Clinical and Pre-Clinical Findings	8
The Neuropharmacological Effects of Magnolol and Honokiol: A Review of Signal Pathways and Molecular Mechanisms	8
Amygdalin Decreases Adhesion and Migration of MDA-MB-231 and MCF-7 Breast Cancer Cell Lines	8
Retinoprotective Effects Of Crocin And Crocetin via Anti-Angiogenic Mechanism in High Glucose-Induced Human Retinal Pigment Epithelium Cells	7
Anti-Inflammatory and Analgesic Effects of Rosehip in Inflammatory Musculoskeletal Disorders and Its Active Molecules	7
Disruption of Wnt/β-catenin Pathway Elevates the Sensitivity of Gastric Cancer Cells to PD-1 Antibody	7
Dihydrotestosterone Induces Chemo-Resistance of Triple-Negative Breast MDA-MB-231 Cancer Cells Towards Doxorubicin Independent of ABCG2 and miR-328-3p	7
TRPC3-Based Protein Signaling Complex as a Therapeutic Target of Myocardial Atrophy	7
Coenzyme Q10 Supplement Rescues Postovulatory Oocyte Aging by Regulating SIRT4 Expression	7
Wnt/β-catenin Antagonists: Exploring New Avenues to Trigger Old Drugs in Alleviating Glioblastoma Multiforme	7
The Impact of Spironolactone on Markers of Myocardial Oxidative Status, Inflammation and Remodeling in Hyperthyroid Rats	7
DNA Methylation in Epithelial Ovarian Cancer: Current Data and Future Perspectives	7
Lactoferrin Suppresses Decreased Locomotor Activities by Improving Dopamine and Serotonin Release in the Amygdala of Ovariectomized Rats	7
MiR-129-2-3p Inhibits Esophageal Carcinoma Cell Proliferation, Migration, and Invasion via Targeting DNMT3B	7
Bovine lactoferrin as a Modulator of Neuroendocrine Components of Stress	7
Protective Potential of Ginkgo biloba Against an ADHD-like Condition	7
Mechanism Involved in Fortification by Berberine in CDDP-Induced Nephrotoxicity	7
Hypotensive Effects of the Triterpene Oleanolic Acid for Cardiovascular Prevention	7
Nutraceuticals and their Derived Nano-Formulations for the Prevention and Treatment of Alzheimer's Disease	6
Azacitidine, as a DNMT Inhibitor Decreases hTERT Gene Expression and Telomerase Activity More Effective Compared with HDAC Inhibitor in Human Head and Neck Squamous Cell Carcinoma Cell Lines	6
DoE Based Optimization and Development of Spray-Dried Chitosan-Coated Alginate Microparticles Loaded with Cisplatin for the Treatment of Cervical Cancer	6
Dynamics and Interplay between Autophagy and Ubiquitin-proteasome system Coordination in Skeletal Muscle Atrophy	6

Diallyl Disulfide Attenuates Methotrexate-Induced Hepatic Oxidative Injury, Inflammation and Apoptosis and Enhances its Anti-Tumor Activity	6
Targeting Signaling Pathway by Curcumin in Osteosarcoma	6
The Role of miR-129-5p in Cancer: A Novel Therapeutic Target	6
Hepatoprotective Effect of Myricetin following Lipopolysaccharide/DGalactosamine: Involvement of Autophagy and Sirtuin 1	6
Inhibitory Effects of Cathepsin K Inhibitor (ODN-MK-0822) on the Paracrine Pro-Osteoclast Factors of Breast Cancer Cells	6
Harnessing the Natural Pool of Polyketide and Non-ribosomal Peptide Family: A Route Map towards Novel Drug Development	6
Quercetin and Glioma: Which Signaling Pathways are Involved?	6
Gamma-Tocotrienol Synergistically Promotes the Anti-proliferative and Pro-apoptotic Effects of Etoposide on Breast Cancer Cell Lines	6
Role of Lacosamide in Preventing Pentylenetetrazole Kindling-Induced Alterations in the Expression of the Gamma-2 Subunit of the GABAA Receptor in Rats	6
Determining the Relative Gene Expression Level of Hypoxia Related Genes in Different Cancer Cell Lines	6
Small Interfering RNAs and their Delivery Systems: A Novel Powerful Tool for the Potential Treatment of HIV Infections	5
Suppression of Molecular Targets and Antiproliferative Effect of Citronellal on Triple-Negative Breast Cancer Cells	5
Carvacrol as a Prospective Regulator of Cancer Targets/Signalling Pathways	5
Exploring the Mitochondrial Apoptotic Cell Death Landscape and Associated Components Serving as Molecular Targets, Primarily for Synthetic and Natural Drugs Targeting Oncology Therapeutics	5
Elimination of the Causes of Poor Sleep Underlying Delirium is a Basic Strategy to Prevent Delirium	5
Evaluation of the Effects of 1,25 Vitamin D3 on Regulatory T Cells and T Helper 17 Cells in Vitamin D-deficient Women with Unexplained Recurrent Pregnancy Loss	5
H3K4 Methylation Status and Lysine Specific Methyltransferase KMT2C Expression Correlate with Prognosis in Lung Adenocarcinoma	5
Resveratrol Augments Doxorubicin and Cisplatin Chemotherapy: A Novel Therapeutic Strategy	5
Eucommia Leaf Extract Induces BDNF Production in Rat Hypothalamus and Enhances Lipid Metabolism and Aerobic Glycolysis in Rat Liver	5
The Mechanistic Role of Thymoquinone in Parkinson's Disease: Focus on Neuroprotection in Pre-Clinical Studies	5
Impact of Buprenorphine on Learning and Memory Ability, Oxidative Status and Inflammation in the Hippocampus of Rats	5
Dantrolene Potentiates the Antineoplastic Effect of Sorafenib in Hepatocellular Carcinoma via Targeting Ca+2/PI3K Signaling Pathway	5
PiWi RNA in Neurodevelopment and Neurodegenerative Disorders	5
Nano-Nutraceuticals Dietary Supplements for Athletes: An Eminent Approach for Managing Traumatic Brain Injuries	5
Protective Effects of Antrodia cinnamomea and Its Constituent Compound Dehydroeburicoic Acid 32 Against Alcoholic Fatty Liver Disease	5
The Therapeutic Effect and Mechanism of Qishen Yiqi Dripping Pills on Cardiovascular and Cerebrovascular Diseases and Diabetic Complications	5
MicroRNA Regulation of Androgen Receptor in Castration-Resistant Prostate Cancer: Premises, Promises, and Potentials	5
Immunomodulatory Therapeutic Effects of Curcumin on M1/M2 Macrophage Polarization in Inflammatory Diseases	5
Hypoxia Boosts Aerobic Glycolysis in Carcinoma: A Complex Process for Tumour Development	5
Characterization of a New Positive Allosteric Modulator of AMPA Receptors - PAM-43: Specific Binding of the Ligand and its Ability to Potentiate AMPAR Currents	5
Comprehensive Analysis of SARS-COV-2 Drug Targets and Pharmacological Aspects in Treating the COVID-19	5
Agomelatine: An Astounding Sui-generis Antidepressant?	5