OOIR: Observatory of International Research

Papers

(The TQCC of Chinese Journal of Natural Medicines is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
New tirucallane-type triterpenoids from the resin of Boswellia carteriiand their NO inhibitory activities	60
20(S)-ginsenoside Rh1 alleviates T2DM induced liver injury via the Akt/FOXO1 pathway	29
New antibacterial depsidones from an ant-derived fungus Spiromastix sp. MY-1	23
Recent progress on anti-Candida natural products	19
The anti-neoplastic activities of aloperine in HeLa cervical cancer cells are associated with inhibition of the IL-6-JAK1-STAT3 feedback loop	15
Ziyuglycoside II inhibits the growth of digestive system cancer cells through multiple mechanisms	14
Flavonoids from the roots and rhizomes of Sophora tonkinensis and their in vitro anti-SARS-CoV-2 activity	13
Buqi-Tongluo Decoction inhibits osteoclastogenesis and alleviates bone loss in ovariectomized rats by attenuating NFATc1, MAPK, NF-κB signaling	13
Recent advances, strategies, and future perspectives of peptide-based drugs in clinical applications	12
Traditional Chinese medicine enables the development of small-molecule inhibitors of HSP47, future therapeutic implication in venous thromboembolism	12
Research progress of small-molecule natural medicines for the treatment of ischemic stroke	12
Heme peroxidases are responsible for the dehydrogenation and oxidation metabolism of harmaline into harmine	12
Demethylenetetrahydroberberine protects dopaminergic neurons in a mouse model of Parkinson's disease	11
Fu-Zheng-Yi-Liu Formula inhibits the stem cells and metastasis of prostate cancer via tumor-associated macrophages/C-C motif chemokine ligand 5 pathway in tumor microenvironment	10
The bioinformatics and metabolomics research on anti-hypoxic molecular mechanisms of Salidroside via regulating the PTEN mediated PI3K/Akt/NF-κB signaling pathway	10
Exposure to ephedrine attenuates Th1/Th2 imbalance underlying OVA-induced asthma through airway epithelial cell-derived exosomal lnc-TRPM2-AS	10
New prenylated flavonoid glycosides derived from Epimedium wushanense by β-glucosidase hydrolysis and their testosterone production-promoting effects	9
Targeting the biological activity and biosynthesis of hyperforin: a mini-review	9
Jujuboside A inhibits oxidative stress damage and enhances immunomodulatory capacity of human umbilical cord mesenchymal stem cells through up-regulating IDO expression	9
Anti-pseudo-allergic components in licorice extract inhibit mast cell degranulation and calcium influx	9
Bavachin induces apoptosis in colorectal cancer cells through Gadd45a via the MAPK signaling pathway	9
Diverse sesquiterpenoids from Litsea lancilimba Merr. with potential neuroprotective effects against H2O2-induced SH-SY5Y cell injury	9
Neotuberostemonine and tuberostemonine ameliorate pulmonary fibrosis through suppressing TGF-β and SDF-1 secreted by macrophages and fibroblasts via the PI3K-dependent AKT and ERK pathways	8
Rapid identification of stigmastane-type steroid saponins from Vernonia amygdalina leaf based on α-glucosidase inhibiting activity and molecular networking	8
Dihydroartemisinin attenuates ischemia/reperfusion-induced renal tubular senescence by activating autophagy	7

Recent advances in the culture-independent discovery of natural products using metagenomic approaches	7
New anti-pulmonary fibrosis prenylflavonoid glycosides from Epimedium koreanum	7
Abietane diterpenoids and iridoids from Caryopteris mongolica	7
Discovery of antitumor diterpenoids from Casearia graveolens targeting VEGFR-2 to inhibit angiogenesis	7
Efficacy and safety of Di-Tan Decoction for treating post-stroke neurological disorders: a systematic review and Meta-analysis of randomized clinical trials	7
Reverse metabolomics as a novel strategy to annotate the human metabolome	7
Influence of 6-shogaol potentiated on 5-fluorouracil treatment of liver cancer by promoting apoptosis and cell cycle arrest by regulating AKT/mTOR/MRP1 signalling	7
NO inhibitory constituents from Glycosmis craibii var. glabra	7
Shengmaisan combined with Liuwei Dihuang Decoction alleviates chronic intermittent hypoxia-induced cognitive impairment by activating the EPO/EPOR/JAK2 signaling pathway	6
Utilizing natural products as new E3 ligase ligands for targeted protein degradation	6
Metabolomics as an emerging tool for the pharmacological and toxicological studies on Aconitum alkaloids	6
Studies on blood enrichment and anti-tumor effects of combined Danggui Buxue Decoction, Fe and rhEPO based on colon cancer-related anemia model and gut microbiota modulation	6
Macrocyclic trichothecenes from Myrothecium verrucaria PA 57 and their cytotoxic activity	6
Icariin attenuates vascular endothelial dysfunction by inhibiting inflammation through GPER/Sirt1/HMGB1 signaling pathway in type 1 diabetic rats	6
Bioactive peptides from scorpion venoms: therapeutic scaffolds and pharmacological tools	6
A comprehensive review on wedelolactone: natural sources, total synthesis, and pharmacological activities	6
Luteoloside protects the vascular endothelium against iron overload injury via the ROS/ADMA/DDAH II/eNOS/NO pathway	6
A review of structural modification and biological activities of oleanolic acid	6
Immunomodulatory effects of flazin from Crassostrea sikamea on splenic lymphocytes of Sprague-Dawley rats	6
Three new carabrane sesquiterpenoid derivatives from the whole plant of Carpesium abrotanoides L.	6
A quinolinyl analog of resveratrol improves neuronal damage after ischemic stroke by promoting Parkin-mediated mitophagy	6
Structure-guided isolation of anti-neuroinflammatory sesquiterpene coumarins from Ferula sinkiangensis	6
Natural-derived drug carriers (NDDCs) for precision therapy	5
Highly oxygenated clerodane furanoditerpenoids from the leaves and twigs of Croton yunnanensis	5
New acylphloroglucinol-sesquiterpenoid adducts with antiviral activities from Dryopteris atrata	5
Development of an eco-friendly and fast HPLC method for quantitative analysis of four nucleosides in Cordyceps and related products	5
Molecular quantification of herbs (Herb-Q): a pyrosequencing-based approach and its application in Pinellia ternata	5
Advances in the combination of stem cell exosomes with medical devices-the new direction for combination products	5
Ephedra Herb extract ameliorates adriamycin-induced nephrotic syndrome in rats via the CAMKK2/AMPK/mTOR signaling pathway	5
Hepatic metabolomics combined with network pharmacology to reveal the correlation between the anti-depression effect and nourishing blood effect of Angelicae Sinensis Radix	5
A combined quality evaluation method that integrates chemical constituents, appearance traits and origins of raw Rehmanniae Radix pieces	5
Five new spirosterol saponins from Allii Macrostemonis Bulbus	5
10,11-Dehydrocurvularin attenuates inflammation by suppressing NLRP3 inflammasome activation	5
Simple and robust differentiation of Ganoderma species by high performance thin-layer chromatography coupled with single quadrupole mass spectrometry QDa	5
New triterpenoid saponins from the leaves of Ilex chinensis and their hepatoprotective activity	5
Ziyuglycoside II suppressed the progression of osteosarcoma by coordinating estrogen-related receptor gamma and p53 signaling pathway	5
Dendrobium nobile protects against ovalbumin-induced allergic rhinitis by regulating intestinal flora and suppressing lung inflammation	5
Zishen Huoxue decoction (ZSHX) alleviates ischemic myocardial injury (MI) via Sirt5-β-tubulin mediated synergistic mechanism of “mitophagy-unfolded protein response” and mitophagy	5
Natural-derived porous nanocarriers for the delivery of essential oils	4
Oroxyloside protects against dextran sulfate sodium-induced colitis by inhibiting ER stress via PPARγ activation	4
Marsdenia tenacissima injection induces the apoptosis of prostate cancer by regulating the AKT/GSK3β/STAT3 signaling axis	4
Panax notoginseng saponins prevent colitis-associated colorectal cancer via inhibition IDO1 mediated immune regulation	4
Steroid and triterpenoid saponins from the rhizomes of Paris polyphylla var. stenophylla	4
Xenopus GLP-1-based glycopeptides as dual glucagon-like peptide 1 receptor/glucagon receptor agonists with improved in vivo stability for treating diabetes and obesity	4
Neutrophil CC1 plays a protective role in orthotopic liver transplantation: views from the perspective of natural compounds	4
Cytotoxic diaporindene and tenellone derivatives from the fungus Phomopsis lithocarpus	4
A comprehensive review of natural products with anti-hypoxic activity	4
Glasesterterpenoids A−C: three sesterterpenoids with 7-cyclohexyldecahydronaphthalene carbon skeleton isolated from the root of Lindera glauca	4
Covalent flavoproteins: types, occurrence, biogenesis and catalytic mechanisms	4
Investigation of the metabolites of five major constituents from Berberis amurensis in normal and pseudo germ-free rats	4

Seed oil of Brucea javanica induces apoptosis through the PI3K/Akt signaling pathway in acute lymphocytic leukemia Jurkat cells	4
Three new coumarins and a new coumarin glycoside from Micromelum integerrimum	4
Discovery of alkaloids from the leaves of Isatis indigotica Fortune with neuroprotective activity	4
Germacranolide sesquiterpenes from Carpesium cernuum and their anti-leukemia activity	4
Hernandezine promotes cancer cell apoptosis and disrupts the lysosomal acidic environment and cathepsin D maturation	4
Ethnopharmacology, chemodiversity, and bioactivity of Cephalotaxus medicinal plants	4
Honokiol: A naturally occurring lignan with pleiotropic bioactivities	4
Ent-pimarane and ent-kaurane diterpenoids from Siegesbeckia pubescens and their anti-endothelial damage effect in diabetic retinopathy	4
Therapeutic potential and mechanism of Chinese herbal medicines in treating fibrotic liver disease	4
New di-spirocyclic labdane diterpenoids from the aerial parts of Leonurus japonicus	4
Repurposing diacerein to suppress colorectal cancer growth by inhibiting the DCLK1/STAT3 signaling pathway	4
Traditional Chinese medicine-based drug delivery systems for anti-tumor therapies	4
Dysideanones F—G and dysiherbols D—E, unusual sesquiterpene quinones with rearranged skeletons from the marine sponge Dysidea avara	4
Tripterygium wilfordii multiglycoside-induced hepatotoxicity via inflammation and apoptosis in zebrafish	4
Physalin B reduces Aβ secretion through down-regulation of BACE1 expression by activating FoxO1 and inhibiting STAT3 phosphorylation	4
Transcriptomic profile of human erythroleukemia cells in response to Sargassum fusiforme polysaccharide and its structure analysis	4
Tu-Xian Decoction ameliorates diabetic cognitive impairment by inhibiting DAPK-1	3
Eucommia lignans alleviate the progression of diabetic nephropathy through mediating the AR/Nrf2/HO-1/AMPK axis in vivo and in vitro	3
An inulin-type fructan CP-A from Codonopsis pilosula attenuates experimental colitis in mice by promoting autophagy-mediated inactivation of NLRP3 inflammasome	3
Periplaneta americana extract promotes infectious diabetic ulcers wound healing by downregulation of LINC01133/SLAMF9	3
Microbial-host-isozyme: a new territory for understanding personalized responses towards drug therapy	3
Mechanisms of Compound Kushen Injection for the treatment of bladder cancer based on bioinformatics and network pharmacology with experimental validation	3
Chemical composition-based characterization of the anti-allergic effect of Guominkang Formula on IgE-mediated mast cells activation and passive cutaneous anaphylaxis	3
Sustainable utilization of precious Chinese medicines: challenges and the road ahead	3
Xuebijing alleviates LPS-induced acute lung injury by downregulating pro-inflammatory cytokine production and inhibiting gasdermin-E-mediated pyroptosis of alveolar epithelial cells	3
Ginsenoside-Rg1 combined with a conditioned medium from induced neuron-like hUCMSCs alleviated the apoptosis in a cell model of ALS through regulating the NF-κB/Bcl-2 pathway	3
Comparison of Murraya exotica and Murraya paniculata by fingerprint analysis coupled with chemometrics and network pharmacology methods	3
Integrating 16S sequencing and metabolomics study on anti-rheumatic mechanisms against collagen-induced arthritis of Wantong Jingu Tablet	3
Design and synthesis of antiviral pseudo-natural products through effective one-step acylmethylation macrocyclization	3
Korean red ginseng alleviates benign prostatic hyperplasia by dysregulating androgen receptor signaling and inhibiting DRP1-mediated mitochondrial fission	3
Inonotus obliquus (Chaga) against HFD/STZ-induced glucolipid metabolism disorders and abnormal renal functions by regulating NOS-cGMP-PDE5 signaling pathway	3
Determining the protective effects of Ma-Mu-Ran Antidiarrheal Capsules against acute DSS-induced enteritis using 16S rRNA gene sequencing and fecal metabolomics	3
Therapeutic potential of alkaloid extract from Codonopsis Radix in alleviating hepatic lipid accumulation: insights into mitochondrial energy metabolism and endoplasmic reticulum stress regulation in	3
Polygalacin D inhibits the growth of hepatocellular carcinoma cells through BNIP3L-mediated mitophagy and endogenous apoptosis pathways	3
Identification of multi-target anti-cancer agents from TCM formula by in silico prediction and in vitro validation	3
Qianjin Wenwu decoction suppresses renal interstitial fibrosis by enhancing the degradation of extracellular matrix in mice with unilateral ureteral obstruction	3
Ginsenoside Rb1 improves brain, lung, and intestinal barrier damage in middle cerebral artery occlusion/reperfusion (MCAO/R) micevia the PPARγ signaling pathway	3
Notoginsenoside Ft1 inhibits colorectal cancer growth by increasing CD8+ T cell proportion in tumor-bearing mice through the USP9X signaling pathway	3
Cyclocarysaponins A–J, dammarane-type triterpenoid glycosides from the leaves of Cyclocarya paliurus	3
Natural endogenous material-based vehicles for delivery of macromolecular drugs	3
Mulberry leaf flavonoids activate BAT and induce browning of WAT to improve type 2 diabetes via regulating the AMPK/SIRT1/PGC-1α signaling pathway	3
Five Rutaceae family ethanol extracts alleviate H2O2 and LPS-induced inflammation via NF-κB and JAK-STAT3 pathway in HaCaT cells	3
Carrimycin ameliorates lipopolysaccharide and cecal ligation and puncture-induced sepsis in mice	3
Exploring the mechanism of Buxue Yimu Pill on hemorrhagic anemia through molecular docking, network pharmacology and experimental validation	3
Anti-inflammatory germacrane-type sesquiterpene lactones from Vernonia sylvatica	3
Tianxiangdan (TXD) alleviates myocardial ischemia reperfusion-induced ferroptosis through the activation of estrogen receptor alpha (ERα)	3