OOIR: Observatory of International Research

Papers

(The TQCC of Chinese Journal of Natural Medicines is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Natural-derived drug carriers (NDDCs) for precision therapy	141
Multidrug resistance reversal effect of tenacissoside I through impeding EGFR methylation mediated by PRMT1 inhibition	81
Targeting the biological activity and biosynthesis of hyperforin: a mini-review	32
Therapeutic potential of Ziziphora clinopodioides in cardiovascular diseases: a review	22
Dihydroartemisinin attenuates ischemia/reperfusion-induced renal tubular senescence by activating autophagy	21
Bavachin induces apoptosis in colorectal cancer cells through Gadd45a via the MAPK signaling pathway	19
Dendrobium nobile protects against ovalbumin-induced allergic rhinitis by regulating intestinal flora and suppressing lung inflammation	18
Penicipenoids A−G, antioxidant and anti-inflammatory cadinane sesquiterpenoids with rearranged carbon skeletons from the marine sponge symbiotic Penicillium sp. 5975	17
Design and synthesis of novel saponin-triazole derivatives in the regulation of adipogenesis	15
Ephedra Herb extract ameliorates adriamycin-induced nephrotic syndrome in rats via the CAMKK2/AMPK/mTOR signaling pathway	14
Inonotus obliquus (Chaga) against HFD/STZ-induced glucolipid metabolism disorders and abnormal renal functions by regulating NOS-cGMP-PDE5 signaling pathway	14
A CYP80B enzyme from Stephania tetrandra enables the 3'-hydroxylation of N-methylcoclaurine and coclaurine in the biosynthesis of benzylisoquinoline alkaloids	13
Glasesterterpenoids A−C: three sesterterpenoids with 7-cyclohexyldecahydronaphthalene carbon skeleton isolated from the root of Lindera glauca	12
Repurposing diacerein to suppress colorectal cancer growth by inhibiting the DCLK1/STAT3 signaling pathway	12
Taohe Chengqi decoction inhibits PAD4-mediated neutrophil extracellular traps and mitigates acute lung injury induced by sepsis	12
Five Rutaceae family ethanol extracts alleviate H2O2 and LPS-induced inflammation via NF-κB and JAK-STAT3 pathway in HaCaT cells	12
Neutrophil CC1 plays a protective role in orthotopic liver transplantation: views from the perspective of natural compounds	12
Anti-cancer and anti-inflammatory effects of flavan-4-ol and flavan glycosides from the roots of Pronephrium penangianum	11
Ginsenoside Rb1 improves brain, lung, and intestinal barrier damage in middle cerebral artery occlusion/reperfusion (MCAO/R) micevia the PPARγ signaling pathway	11
Pure drug nanomedicines - where we are?	11
Research progress on new techniques and methods for identifying active ingredients in traditional Chinese medicine	11
De novo production of 24-epi-ergosterol in bioengineered yeast	10
Covalent flavoproteins: types, occurrence, biogenesis and catalytic mechanisms	10
New di-spirocyclic labdane diterpenoids from the aerial parts of Leonurus japonicus	10
Progress in approved drugs from natural product resources	10

Network pharmacology and AI: illuminating the path to precision herbal medicine in Ganoderma spp.	9
Identification of natural product-based drug combination (NPDC) using artificial intelligence	9
Atractylodimers A−D, unprecedented sesquiterpenoid dimers with cage-like skeletons from Atractylodes macrocephala and their neuroprotective activities	9
First-in-class drug oroxylin A tablets for treating hepatic and gastrointestinal disorders: from preclinical development to clinical research	9
Guijiajiao (Colla Carapacis et Plastri, CCP) prevents male infertility via gut microbiota modulation	9
The ethyl acetate extract of Schefflera kwangsiensis ameliorates oxaliplatin-induced peripheral neuropathic pain via SERCA2b	9
Ginkgo biloba extract protects against depression-like behavior in mice through regulating gut microbial bile acid metabolism	9
TSZAF monomer combination downregulates the Wnt/β-catenin signaling pathway and inhibits neutrophil recruitment to prevent lung cancer metastasis	9
Five new terpenoids from Viburnum odoratissimum var. sessiliflorum	9
Transdermal delivery of natural products against atopic dermatitis	9
Potential role of the protein interactome in translating TCM theory and clinical practice into modern biomedical knowledge	9
Neuroprotective and antidiabetic lanostane-type triterpenoids from the fruiting bodies of Ganoderma theaecolum	9
Discovery of fernane-type triterpenoids from Diaporthe discoidispora using genome mining and HSQC-based SMART technology	8
Four new diphenyl ether derivatives from a mangrove endophytic fungus Epicoccum sorghinum	8
Dimeric sesquiterpenoids with anti-inflammatory activities from Inula britannica	8
Cytotoxic lignans from the roots and rhizomes of Diphylleia sinensis, a China’s endemic plant species	8
Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo	8
An overview of the advantageous effects and underlying mechanisms of natural polysaccharides in inflammatory bowel disease	8
Talaketides A−G, linear polyketides with prostate cancer cytotoxic activity from the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41027	8
The chemical structures, biosynthesis, and biological activities of secondary metabolites from the culinary-medicinal mushrooms of the genus Hericium: a review	8
Saponins from Aralia taibaiensis protect against brain ischemia/reperfusion injuries by regulating the apelin/AMPK pathway	8
Study on the dynamic variation of the secondary metabolites in Viscum coloratum using targeted metabolomics	8
Stem-leaf saponins of Panax notoginseng attenuate experimental Parkinson's disease progression in mice by inhibiting microglia-mediated neuroinflammation via P2Y2R/PI3K/AKT/NFκB signaling pathway	8
Natural products targeting NLRP3 inflammasome for metabolic dysfunction-associated fatty liver disease: the known unknowns	8
Rehmanniae Radix Praeparata aqueous extract improves hepatic ischemia/reperfusion injury by restoring intracellular iron homeostasis	7
A polysaccharide from Arthrospira platensis alleviates pancreatic cancerassociated with negatively regulating galectin-3 and glypican-6 expression	7
KG-CNNDTI: a knowledge graph-enhanced prediction model for drug-target interactions and application in virtual screening of natural products against Alzheimer’s disease	7
Eudesmane-guaiane sesquiterpenoid dimers from Aucklandia costus trigger paraptosis-like cell death via ROS accumulation and MAPK hyperactivation	7
SBC (Sanhuang Xiexin Tang combined with Baihu Tang plus Cangzhu) alleviates NAFLD by enhancing mitochondrial biogenesis and ameliorating inflammation in obese patients and mice	7
Intervention of natural products targeting novel mechanisms after myocardial infarction	7
Identification and screening of bioactive peptides against nephropathy derived from Mantidis Oötheca based on complement C3 inhibition	7
The extract of Cyperus rotundus rhizome promotes hair growth and modulates hair cycle in vivo and in vitro	7
Dammarane-type triterpenoid saponins isolated from Gynostemma pentaphyllum ameliorate liver fibrosis via agonizing PP2Cα and inhibiting deposition of extracellular matrix	7
Natural diosmin alleviating obesity and nonalcoholic fatty liver disease by regulating the activating the AMP-activated protein kinase (AMPK) pathway	7
Artemdubinoids A–N: novel sesquiterpenoids with antihepatoma cytotoxicity from Artemisia dubia	7
Structurally diverse terpenoids from Pseudotsuga brevifolia and their inhibitory effects against ACL and ACC1 enzymes	7
Anti-inflammatory effects of aucubin in cellular and animal models of rheumatoid arthritis	7
Pulchinenoside B4 attenuates gouty arthritis by regulating NLRP3 inflammasome and macrophage polarization: a transcriptomics-based analysis	7
Antimicrobial indole alkaloids from Tabernaemontana corymbosa	7
Thirteen new peptaibols with antimicrobial activities from Trichoderma sp.	7
Anti-pseudo-allergic components in licorice extract inhibit mast cell degranulation and calcium influx	6
New pimarane diterpenoids with antibacterial activity from fungus Arthrinium sp. ZS03	6
Abietane diterpenoids and iridoids from Caryopteris mongolica	6
A comprehensive review of natural products with anti-hypoxic activity	6
Anti-hepatitis B virus activities of natural products and their antiviral mechanisms	6
NO inhibitory constituents from Glycosmis craibii var. glabra	6
Protective mechanisms of Qingda granule in hypertensive kidney injury: Focus on ERK/RSK1-mediated mitochondrial protection	6
Leveraging microbial natural products for pharmaceutical innovation: a vision of inspiration and future prospects	6
Esculetin triggers ferroptosis via inhibition of the Nrf2-xCT/GPx4 axis in hepatocellular carcinoma	6
Huatuo Zaizao Pills improve myocardial ischemia by inhibiting extracellular calcium influx	6

Diverse sesquiterpenoids from Litsea lancilimba Merr. with potential neuroprotective effects against H2O2-induced SH-SY5Y cell injury	6
10,11-Dehydrocurvularin attenuates inflammation by suppressing NLRP3 inflammasome activation	6
Structure-guided isolation of anti-neuroinflammatory sesquiterpene coumarins from Ferula sinkiangensis	6
Silibinin meglumine ameliorates hepatic encephalopathy via inhibiting UCP2-mediated oxidative stress and mitochondrial dysfunction	5
Nigella sativa L. seed extract alleviates oxidative stress-induced cellular senescence and dysfunction in melanocytes	5
Atractylodis Rhizoma-Atractylodis Macrocephala Rhizoma herbal pair restores intestinal mucosal barrier function in ulcerative colitis via activating Epac1/Rap1 pathway and inhibiting PI3K/AKT pathway	5
Anti-inflammatory germacrane-type sesquiterpene lactones from Vernonia sylvatica	5
Five new spirosterol saponins from Allii Macrostemonis Bulbus	5
Ginsenoside-Rg1 combined with a conditioned medium from induced neuron-like hUCMSCs alleviated the apoptosis in a cell model of ALS through regulating the NF-κB/Bcl-2 pathway	5
Exosomes derived from Nr-CWS pretreated MSCs facilitate diabetic wound healing by promoting angiogenesis via the circIARS1/miR-4782-5p/VEGFA axis	5
Wenxia Changfu Formula inhibits NSCLC metastasis by halting TAMs-induced epithelial-mesenchymal transition via antagonisticallymodulating CCL18	5
NUMB endocytic adaptor protein (NUMB) mediates the anti-hepatic fibrosis effect of artesunate (ART) by inducing senescence in hepatic stellate cells (HSCs)	5
Potential role of Natural Herbal Tea as a healthy beverage in reducing the risk of liver cancer and chronic liver disease mortality	5
Paeoniflorin alleviates depression by inhibiting the activation of NLRP3 inflammasome via promoting mitochondrial autophagy	5
Korean red ginseng alleviates benign prostatic hyperplasia by dysregulating androgen receptor signaling and inhibiting DRP1-mediated mitochondrial fission	5
Eucommia lignans alleviate the progression of diabetic nephropathy through mediating the AR/Nrf2/HO-1/AMPK axis in vivo and in vitro	5
Taohong Siwu Decoction: a classical Chinese prescription for treatment of orthopedic diseases	5
TCM network pharmacology: new perspective integrating network target with artificial intelligence and multi-modal multi-omics technologies	5
Pinelliae Rhizoma: a systematic review on botany, ethnopharmacology, phytochemistry, preclinical and clinical evidence	5
Structurally diverse sesquiterpenoids with anti-MDR cancer activity from Penicillium roqueforti	5
A comprehensive review on wedelolactone: natural sources, total synthesis, and pharmacological activities	5
Chemical composition-based characterization of the anti-allergic effect of Guominkang Formula on IgE-mediated mast cells activation and passive cutaneous anaphylaxis	5
Therapeutic potential and mechanism of Chinese herbal medicines in treating fibrotic liver disease	5
MolP-PC: a multi-view fusion and multi-task learning framework for drug ADMET property prediction	4
Houttuynia cordata polysaccharides alleviate ulcerative colitis by restoring intestinal homeostasis	4
Commentary on “A population of stem cells with strong regenerative potential discovered in deer antlers ”	4
The signaling pathways of atherosclerosis regulated by Taohong Siwu Decoction	4
Deep chemical identification of phytoecdysteroids in Achyranthes bidentata Blume by UHPLC coupled with linear ion trap-Orbitrap mass spectrometry and targeted isolation	4
Loganin inhibits the ROS-NLRP3-IL-1β axis by activating the NRF2/HO-1 pathway against osteoarthritis	4
Naturally derived oncolytic peptides: from discovery to clinical translation	4
Puerarin inhibits inflammation and lipid accumulation in alcoholic liver disease through regulating MMP8	4
Structurally diverse rhamnofolane, tigliane, and daphnane diterpenoids from Euphorbia wallichii as anti-liver fibrosis agents	4
Exploring artificial intelligence approaches for predicting synergistic effects of active compounds in traditional Chinese medicine based on molecular compatibility theory	4
Geranylated or prenylated flavonoids from Cajanus volubilis	4
Comprehensive analysis of the antibacterial activity of 5,8-dihydroxy-1,4-naphthoquinone derivatives against methicillin-resistant Staphylococcus aureus	4
The combination of EGCG with warfarin reduces deep vein thrombosis in rabbits through modulating HIF-1α and VEGF via the PI3K/AKT and ERK1/2 signaling pathways	4
Isodons A−H, seco-abietane and abietane-type diterpenoids from Isodon lophanthoides: isolation, structural elucidation, and anti-cholestatic activity	4
Evaluation of pharmacokinetics and metabolism of three marine-derived piericidins for guiding drug lead selection	4
New nor-ent-halimane and nor-clerodane diterpenes from Callicarpa integerrima with anti-MRSA activity	4
Micranthin B alleviates metabolic dysfunction-associated steatohepatitis by targeting G3BP1 to improve stress granule-mediated endoplasmic reticulum stress	4
Unveiling the therapeutic mechanism of Epimedium Herba on prostate cancer through network pharmacology and experimental validation	4
Xanthones from Garcinia pedunculata and Garcinia nujiangensis and their anti-inflammatory activity	4
Herbal medicines for insomnia through regulating 5-hydroxytryptamine receptors: a systematic review	4
Heterologous production of bioactive xenoacremone analogs in Aspergillus nidulans	4
Potassium dehydroandrographolide succinate regulates the MyD88/CDH13 signaling pathway to enhance vascular injury-induced pathological vascular remodeling	4
Integrative SMRT sequencing and ginsenoside profiling analysis provide insights into the biosynthesis of ginsenoside in Panax quinquefolium	4
Effect and mechanism of Chinese medicine on inhibiting the senescence of mesenchymal stem cells	4
Research progress of 3-n-butylphthalide and its derivatives in combating cerebral ischemia	4
Five new meroterpenoids from Rhododendron anthopogonoides and their anti-inflammatory activity	4