OOIR: Observatory of International Research

Papers

(The TQCC of Chinese Journal of Natural Medicines is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
TCM network pharmacology: A new trend towards combining computational, experimental and clinical approaches	145
The pharmacology, toxicology and therapeutic potential of anthraquinone derivative emodin	39
Research progress on the source, production, and anti-cancer mechanisms of paclitaxel	34
Recent advances of traditional Chinese medicine on the prevention and treatment of COVID-19	28
A review of the phytochemistry and pharmacological activities of Ephedra herb	18
HIF-1: structure, biology and natural modulators	17
Rubus chingii Hu: an overview of botany, traditional uses, phytochemistry, and pharmacology	15
A systematic review of pharmacological activities, toxicological mechanisms and pharmacokinetic studies on Aconitum alkaloids	15
Dendrobium officinale Kimura et Migo and American ginseng mixture: A Chinese herbal formulation for gut microbiota modulation	14
Network pharmacology approaches for research of Traditional Chinese Medicines	14
Traditional Chinese medicine network pharmacology study on exploring the mechanism of Xuebijing Injection in the treatment of coronavirus disease 2019	14
Andrographolide as a potent and promising antiviral agent	14
Advances in biosynthesis of triterpenoid saponins in medicinal plants	14
Identification of medicinal plants within the Apocynaceae family using ITS2 and psbA-trnH barcodes	14
Complete chloroplast genome of Salvia plebeia: organization, specific barcode and phylogenetic analysis	13
Mangiferin inhibited neuroinflammation through regulating microglial polarization and suppressing NF-κB, NLRP3 pathway	13
Panax notoginseng saponins prevent colitis-associated colorectal cancer development: the role of gut microbiota	13
Comparative metabolism study on chlorogenic acid, cryptochlorogenic acid and neochlorogenic acid using UHPLC-Q-TOF MS coupled with network pharmacology	12
Jiedu Sangen decoction inhibits chemoresistance to 5-fluorouracil of colorectal cancer cells by suppressing glycolysis via PI3K/AKT/HIF-1α signaling pathway	12
Advances on hormone-like activity of Panax ginseng and ginsenosides	12
A four-component combination derived from Huang-Qin Decoction significantly enhances anticancer activity of irinotecan	11
Comprehensive profiling and characterization of the absorbed components and metabolites in mice serum and tissues following oral administration of Qing-Fei-Pai-Du decoction by UHPLC-Q-Exactive-Orbitra	11
Xinglou Chengqi Decoction improves neurological function in experimental stroke mice as evidenced by gut microbiota analysis and network pharmacology	11
Taurochenodeoxycholic acid mediates cAMP-PKA-CREB signaling pathway	10
Effects of chitooligosaccharide-zinc on the ovarian function of mice with premature ovarian failure via the SESN2/NRF2 signaling pathway	9

Physalin B reduces Aβ secretion through down-regulation of BACE1 expression by activating FoxO1 and inhibiting STAT3 phosphorylation	9
Chemical profiling of Huashi Baidu prescription, an effective anti-COVID-19 TCM formula, by UPLC-Q-TOF/MS	9
Therapeutic effect of neohesperidin on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes	9
Hypoglycemic activity of puerarin through modulation of oxidative stress and mitochondrial function via AMPK	9
Isochlorogenic acid (ICGA): natural medicine with potentials in pharmaceutical developments	9
Modern research thoughts and methods on bio-active components of TCM formulae	8
Recent progress on betulinic acid and its derivatives as antitumor agents: a mini review	8
The bioinformatics and metabolomics research on anti-hypoxic molecular mechanisms of Salidroside via regulating the PTEN mediated PI3K/Akt/NF-κB signaling pathway	8
Mechanisms exploration of Angelicae Sinensis Radix and Ligusticum Chuanxiong Rhizoma herb-pair for liver fibrosis prevention based on network pharmacology and experimental pharmacologylogy	8
Drimane-type sesquiterpenoids from fungi	8
Pancreatic lipase inhibitory constituents from Fructus Psoraleae	8
Nagilactone E increases PD-L1 expression through activation of c-Jun in lung cancer cells	8
Silybin alleviates hepatic lipid accumulation in methionine-choline deficient diet-induced nonalcoholic fatty liver disease in mice via peroxisome proliferator-activated receptor α	8
Cordycepin inhibits pancreatic cancer cell growth in vitro and in vivo via targeting FGFR2 and blocking ERK signaling	8
Study on the action mechanism of Wuling Powder on treating osteoporosis based on network pharmacology	7
Honokiol: A naturally occurring lignan with pleiotropic bioactivities	7
Natural products as potent inhibitors of hypoxia-inducible factor-1α in cancer therapy	7
Protective effect of paeoniflorin on H2O2 induced Schwann cells injury based on network pharmacology and experimental validation	7
Advance in glycosyltransferases, the important bioparts for production of diversified ginsenosides	7
Bufalin-induced cardiotoxicity: new findings into mechanisms	7
Studies on blood enrichment and anti-tumor effects of combined Danggui Buxue Decoction, Fe and rhEPO based on colon cancer-related anemia model and gut microbiota modulation	7
EGCG and ECG induce apoptosis and decrease autophagy via the AMPK/mTOR and PI3K/AKT/mTOR pathway in human melanoma cells	7
Paris saponin VII, a direct activator of AMPK, induces autophagy and exhibits therapeutic potential in non-small-cell lung cancer	6
β-Elemene induces apoptosis and autophagy in colorectal cancer cells through regulating the ROS/AMPK/mTOR pathway	6
In vitro antitumor effect of cucurbitacin E on human lung cancer cell line and its molecular mechanism	6
Ziyuglycoside II inhibits the growth of digestive system cancer cells through multiple mechanisms	6
Development of liquiritigenin-phospholipid complex with the enhanced oral bioavailability	6
Candidate genes involved in the biosynthesis of lignan in Schisandra chinensis fruit based on transcriptome and metabolomes analysis	6
Esculetin protects against early sepsis via attenuating inflammation by inhibiting NF-κB and STAT1/STAT3 signaling	6
Panax notoginseng saponins prevent colitis-associated colorectal cancer via inhibition IDO1 mediated immune regulation	6
Dracocephalum palmatum Stephan extract induces apoptosis in human prostate cancer cells via the caspase-8-mediated extrinsic pathway	6
Anti-rheumatoid arthritis potential of diterpenoid fraction derived from Rhododendron molle fruits	6
Engineering CrtW and CrtZ for improving biosynthesis of astaxanthin in Escherichia coli	6
Tao-Hong-Si-Wu Decoction promotes angiogenesis after cerebral ischaemia in rats via platelet microparticles	6
New furo[3,2-h]isochroman from the mangrove endophytic fungus Aspergillus sp. 085242	6
Gualou-Xiebai-Banxia decoction protects against type II diabetes with acute myocardial ischemia by attenuating oxidative stress and apoptosis via PI3K/Akt/eNOS signaling	5
Preparation and evaluation of a water-in-oil nanoemulsion drug delivery system loaded with salidroside	5
Development of an eco-friendly and fast HPLC method for quantitative analysis of four nucleosides in Cordyceps and related products	5
Recent progress on anti-Candida natural products	5
Immunomodulatory effects of flazin from Crassostrea sikamea on splenic lymphocytes of Sprague-Dawley rats	5
Genome-wide identification and analysis of AP2/ERF transcription factors related to camptothecin biosynthesis in Camptotheca acuminata	5
Biosynthesis and regulation of diterpenoids in medicinal plants	5
A network pharmacology-based strategy for predicting the protective mechanism of Ginkgo biloba on damaged retinal ganglion cells	5
Ethnopharmacology, chemodiversity, and bioactivity of Cephalotaxus medicinal plants	5
Cytotoxic diaporindene and tenellone derivatives from the fungus Phomopsis lithocarpus	5
Three new carabrane sesquiterpenoid derivatives from the whole plant of Carpesium abrotanoides L.	5
Physiological and transcriptional responses to heat stress in a typical phenotype of Pinellia ternata	5
Four new diphenyl ether derivatives from a mangrove endophytic fungus Epicoccum sorghinum	5
Triterpenoid saponins and phenylpropanoid glycoside from the roots of Ardisia crenata and their cytotoxic activities	5
Investigation of the metabolites of five major constituents from Berberis amurensis in normal and pseudo germ-free rats	5

New triterpenoid saponins from the leaves of Ilex chinensis and their hepatoprotective activity	5
Ephedra Herb extract ameliorates adriamycin-induced nephrotic syndrome in rats via the CAMKK2/AMPK/mTOR signaling pathway	5
New meroterpenoids and C-methylated flavonoid isolated from Baeckea frutescens	5
Characterization of the chemical constituents of Jie-Geng-Tang and the metabolites in the serums and lungs of mice after oral administration by LC-Q-TOF-MS	5
Identification of anti-cancer compounds from natural products	4
Ganoderic acid A protects lens epithelial cells from UVB irradiation and delays lens opacity	4
Transcriptome sequencing and metabolome analysis reveal the mechanism of Shuanghua Baihe Tablet in the treatment of oral mucositis	4
Anti-anaphylactic potential of benzoylpaeoniflorin through inhibiting HDC and MAPKs from Paeonia lactiflora	4
A review: biosynthesis of plant-derived labdane-related diterpenoids	4
Molecular cloning and functional characterization of multiple ApOSCs from Andrographis paniculata	4
Protective effect of Pai-Nong-San against AOM/DSS-induced CAC in mice through inhibiting the Wnt signaling pathway	4
Simple and robust differentiation of Ganoderma species by high performance thin-layer chromatography coupled with single quadrupole mass spectrometry QDa	4
Five new terpenoids from Viburnum odoratissimum var. sessiliflorum	4
Influence of 6-shogaol potentiated on 5-fluorouracil treatment of liver cancer by promoting apoptosis and cell cycle arrest by regulating AKT/mTOR/MRP1 signalling	4
Chemical ecology-driven discovery of bioactive marine natural products as potential drug leads	4
Pathogenesis of NASH and Promising Natural Products	4
Anti-inflammatory effects of aucubin in cellular and animal models of rheumatoid arthritis	4
Research progress on naturally-occurring and semi-synthetic ocotillol-type ginsenosides in the genus Panax L. (Araliaceae)	4
Novel SNP markers on ginsenosides biosynthesis functional gene for authentication of ginseng herbs and commercial products	4
Dysideanones F—G and dysiherbols D—E, unusual sesquiterpene quinones with rearranged skeletons from the marine sponge Dysidea avara	4
Houttuynia cordata polysaccharides alleviate ulcerative colitis by restoring intestinal homeostasis	4
Transcriptomic profile of human erythroleukemia cells in response to Sargassum fusiforme polysaccharide and its structure analysis	4
Integrative SMRT sequencing and ginsenoside profiling analysis provide insights into the biosynthesis of ginsenoside in Panax quinquefolium	4
Efficacy and safety of Di-Tan Decoction for treating post-stroke neurological disorders: a systematic review and Meta-analysis of randomized clinical trials	4
Strictosidine synthase, an indispensable enzyme involved in the biosynthesis of terpenoid indole and β-carboline alkaloids	4
Discovery of Eucalyptin C, derived from the fruits of Eucalyptus globulus Labill., as a novel selective PI3Kγ inhibitor for immunosuppressive treatment	4
Recent advances on the structural modification of parthenolide and its derivatives as anticancer agents	4
Revealing the synergistic mechanism of Shenfu Decoction for anti-heart failure through network pharmacology strategy	4
The cardiovascular protective effect and mechanism of calycosin and its derivatives	4
Sangguayin preparation prevents palmitate-induced apoptosis by suppressing endoplasmic reticulum stress and autophagy in db/db mice and MIN6 pancreatic β-cells	4
Polysaccharide from Astragalus membranaceus promotes the activation of human peripheral blood and mouse spleen dendritic cells	4
The combination of EGCG with warfarin reduces deep vein thrombosis in rabbits through modulating HIF-1α and VEGF via the PI3K/AKT and ERK1/2 signaling pathways	4
Phytoglycoprotein isolated from Dioscorea batatas Decne promotes intestinal epithelial wound healing	4
Polyphyllin I promotes cell death via suppressing UPR-mediated CHOP ubiquitination and degradation in non-small cell lung cancer	4
Dendrobium nobile protects against ovalbumin-induced allergic rhinitis by regulating intestinal flora and suppressing lung inflammation	4
Effective fraction from Simiao Wan prevents hepatic insulin resistant by inhibition of lipolysis via AMPK activation	4