OOIR: Observatory of International Research

Papers

(The TQCC of Chinese Journal of Natural Medicines is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Ephedra Herb extract ameliorates adriamycin-induced nephrotic syndrome in rats via the CAMKK2/AMPK/mTOR signaling pathway	86
Targeting the biological activity and biosynthesis of hyperforin: a mini-review	44
Natural-derived drug carriers (NDDCs) for precision therapy	18
Immunomodulatory effects of flazin from Crassostrea sikamea on splenic lymphocytes of Sprague-Dawley rats	18
Dendrobium nobile protects against ovalbumin-induced allergic rhinitis by regulating intestinal flora and suppressing lung inflammation	15
Bavachin induces apoptosis in colorectal cancer cells through Gadd45a via the MAPK signaling pathway	15
Dihydroartemisinin attenuates ischemia/reperfusion-induced renal tubular senescence by activating autophagy	13
Design and synthesis of novel saponin-triazole derivatives in the regulation of adipogenesis	13
Repurposing diacerein to suppress colorectal cancer growth by inhibiting the DCLK1/STAT3 signaling pathway	12
Three new coumarins and a new coumarin glycoside from Micromelum integerrimum	12
New di-spirocyclic labdane diterpenoids from the aerial parts of Leonurus japonicus	12
Covalent flavoproteins: types, occurrence, biogenesis and catalytic mechanisms	11
Neutrophil CC1 plays a protective role in orthotopic liver transplantation: views from the perspective of natural compounds	10
Pure drug nanomedicines - where we are?	10
Five Rutaceae family ethanol extracts alleviate H2O2 and LPS-induced inflammation via NF-κB and JAK-STAT3 pathway in HaCaT cells	9
Inonotus obliquus (Chaga) against HFD/STZ-induced glucolipid metabolism disorders and abnormal renal functions by regulating NOS-cGMP-PDE5 signaling pathway	9
Glasesterterpenoids A−C: three sesterterpenoids with 7-cyclohexyldecahydronaphthalene carbon skeleton isolated from the root of Lindera glauca	9
Anti-cancer and anti-inflammatory effects of flavan-4-ol and flavan glycosides from the roots of Pronephrium penangianum	9
Ginsenoside Rb1 improves brain, lung, and intestinal barrier damage in middle cerebral artery occlusion/reperfusion (MCAO/R) micevia the PPARγ signaling pathway	9
A CYP80B enzyme from Stephania tetrandra enables the 3'-hydroxylation of N-methylcoclaurine and coclaurine in the biosynthesis of benzylisoquinoline alkaloids	8
Identification of Andrographis Herba and its common products using mini-barcode	8
Neuroprotective and antidiabetic lanostane-type triterpenoids from the fruiting bodies of Ganoderma theaecolum	8
Discovery of Eucalyptin C, derived from the fruits of Eucalyptus globulus Labill., as a novel selective PI3Kγ inhibitor for immunosuppressive treatment	8
Progress in approved drugs from natural product resources	8
De novo production of 24-epi-ergosterol in bioengineered yeast	8

Ginkgo biloba extract protects against depression-like behavior in mice through regulating gut microbial bile acid metabolism	8
Bear bile powder attenuates senecionine-induced hepatic sinusoidal obstruction syndrome in mice	8
Metabolomics analysis reveals the renal protective effect of Panax ginseng C. A. Mey in type 1 diabetic rats	8
Transdermal delivery of natural products against atopic dermatitis	8
Five new terpenoids from Viburnum odoratissimum var. sessiliflorum	8
Guijiajiao (Colla Carapacis et Plastri, CCP) prevents male infertility via gut microbiota modulation	8
Potential role of the protein interactome in translating TCM theory and clinical practice into modern biomedical knowledge	7
Stem-leaf saponins of Panax notoginseng attenuate experimental Parkinson's disease progression in mice by inhibiting microglia-mediated neuroinflammation via P2Y2R/PI3K/AKT/NFκB signaling pathway	7
Discovery of fernane-type triterpenoids from Diaporthe discoidispora using genome mining and HSQC-based SMART technology	7
Talaketides A−G, linear polyketides with prostate cancer cytotoxic activity from the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41027	7
Study on the dynamic variation of the secondary metabolites in Viscum coloratum using targeted metabolomics	7
Four new diphenyl ether derivatives from a mangrove endophytic fungus Epicoccum sorghinum	7
Dahuang Zhechong pills inhibit liver cancer growth in a mouse model by reversing Treg/Th1 balance	7
Saponins from Aralia taibaiensis protect against brain ischemia/reperfusion injuries by regulating the apelin/AMPK pathway	7
Cytotoxic lignans from the roots and rhizomes of Diphylleia sinensis, a China’s endemic plant species	6
The chemical structures, biosynthesis, and biological activities of secondary metabolites from the culinary-medicinal mushrooms of the genus Hericium: a review	6
Dimeric sesquiterpenoids with anti-inflammatory activities from Inula britannica	6
Thirteen new peptaibols with antimicrobial activities from Trichoderma sp.	6
Dammarane-type triterpenoid saponins isolated from Gynostemma pentaphyllum ameliorate liver fibrosis via agonizing PP2Cα and inhibiting deposition of extracellular matrix	6
Anti-inflammatory effects of aucubin in cellular and animal models of rheumatoid arthritis	6
Antimicrobial indole alkaloids from Tabernaemontana corymbosa	6
Eudesmane-guaiane sesquiterpenoid dimers from Aucklandia costus trigger paraptosis-like cell death via ROS accumulation and MAPK hyperactivation	6
SBC (Sanhuang Xiexin Tang combined with Baihu Tang plus Cangzhu) alleviates NAFLD by enhancing mitochondrial biogenesis and ameliorating inflammation in obese patients and mice	6
EGCG and ECG induce apoptosis and decrease autophagy via the AMPK/mTOR and PI3K/AKT/mTOR pathway in human melanoma cells	6
Intervention of natural products targeting novel mechanisms after myocardial infarction	6
New pimarane diterpenoids with antibacterial activity from fungus Arthrinium sp. ZS03	6
Anti-hepatitis B virus activities of natural products and their antiviral mechanisms	6
Rehmanniae Radix Praeparata aqueous extract improves hepatic ischemia/reperfusion injury by restoring intracellular iron homeostasis	6
First-in-class drug oroxylin A tablets for treating hepatic and gastrointestinal disorders: from preclinical development to clinical research	6
Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo	6
Natural diosmin alleviating obesity and nonalcoholic fatty liver disease by regulating the activating the AMP-activated protein kinase (AMPK) pathway	6
Bioactive neolignans and lignans from the roots of Paeonia lactiflora	6
Esculetin triggers ferroptosis via inhibition of the Nrf2-xCT/GPx4 axis in hepatocellular carcinoma	6
Artemdubinoids A–N: novel sesquiterpenoids with antihepatoma cytotoxicity from Artemisia dubia	6
Korean red ginseng alleviates benign prostatic hyperplasia by dysregulating androgen receptor signaling and inhibiting DRP1-mediated mitochondrial fission	5
Heme peroxidases are responsible for the dehydrogenation and oxidation metabolism of harmaline into harmine	5
Structure-guided isolation of anti-neuroinflammatory sesquiterpene coumarins from Ferula sinkiangensis	5
Physalin B reduces Aβ secretion through down-regulation of BACE1 expression by activating FoxO1 and inhibiting STAT3 phosphorylation	5
Diverse sesquiterpenoids from Litsea lancilimba Merr. with potential neuroprotective effects against H2O2-induced SH-SY5Y cell injury	5
A comprehensive review on wedelolactone: natural sources, total synthesis, and pharmacological activities	5
Taohong Siwu Decoction: a classical Chinese prescription for treatment of orthopedic diseases	5
Abietane diterpenoids and iridoids from Caryopteris mongolica	5
Five new spirosterol saponins from Allii Macrostemonis Bulbus	5
The anti-neoplastic activities of aloperine in HeLa cervical cancer cells are associated with inhibition of the IL-6-JAK1-STAT3 feedback loop	5
Chemical composition-based characterization of the anti-allergic effect of Guominkang Formula on IgE-mediated mast cells activation and passive cutaneous anaphylaxis	5
Seed oil of Brucea javanica induces apoptosis through the PI3K/Akt signaling pathway in acute lymphocytic leukemia Jurkat cells	5
Anti-pseudo-allergic components in licorice extract inhibit mast cell degranulation and calcium influx	5
NO inhibitory constituents from Glycosmis craibii var. glabra	5
10,11-Dehydrocurvularin attenuates inflammation by suppressing NLRP3 inflammasome activation	5
A comprehensive review of natural products with anti-hypoxic activity	5

Houttuynia cordata polysaccharides alleviate ulcerative colitis by restoring intestinal homeostasis	4
Natural ingredients from Chinese materia medica for pulmonary hypertension	4
Sulfite as the substrate of C-sulfonate metabolism of α, β-unsaturated carbonyl containing andrographolide: analysis of sulfite in rats' intestinal tract and the reaction kinetics of andrographolide w	4
Xanthones from Garcinia pedunculata and Garcinia nujiangensis and their anti-inflammatory activity	4
Eucommia lignans alleviate the progression of diabetic nephropathy through mediating the AR/Nrf2/HO-1/AMPK axis in vivo and in vitro	4
Structurally diverse sesquiterpenoids with anti-MDR cancer activity from Penicillium roqueforti	4
Exosomes derived from Nr-CWS pretreated MSCs facilitate diabetic wound healing by promoting angiogenesis via the circIARS1/miR-4782-5p/VEGFA axis	4
Anti-inflammatory germacrane-type sesquiterpene lactones from Vernonia sylvatica	4
Nigella sativa L. seed extract alleviates oxidative stress-induced cellular senescence and dysfunction in melanocytes	4
Pinelliae Rhizoma: a systematic review on botany, ethnopharmacology, phytochemistry, preclinical and clinical evidence	4
New nor-ent-halimane and nor-clerodane diterpenes from Callicarpa integerrima with anti-MRSA activity	4
Molecular cloning and functional characterization of an isoflavone glucosyltransferase from Pueraria thomsonii	4
Commentary on “A population of stem cells with strong regenerative potential discovered in deer antlers ”	4
Geranyl phenyl ethers from Illicium micranthum and their anti-HBV activity	4
Ginsenoside-Rg1 combined with a conditioned medium from induced neuron-like hUCMSCs alleviated the apoptosis in a cell model of ALS through regulating the NF-κB/Bcl-2 pathway	4
Investigation of the metabolites of five major constituents from Berberis amurensis in normal and pseudo germ-free rats	4
Loganin inhibits the ROS-NLRP3-IL-1β axis by activating the NRF2/HO-1 pathway against osteoarthritis	4
Protective effects of Wuwei Xiaodu Drink against chronic osteomyelitis through Foxp3+CD25+CD4+ Treg cells via the IL-2/STAT5 signaling pathway	4
Herbal medicines for insomnia through regulating 5-hydroxytryptamine receptors: a systematic review	4
NUMB endocytic adaptor protein (NUMB) mediates the anti-hepatic fibrosis effect of artesunate (ART) by inducing senescence in hepatic stellate cells (HSCs)	4
Integrative SMRT sequencing and ginsenoside profiling analysis provide insights into the biosynthesis of ginsenoside in Panax quinquefolium	4
Potential role of Natural Herbal Tea as a healthy beverage in reducing the risk of liver cancer and chronic liver disease mortality	4
β-Elemene induces apoptosis and autophagy in colorectal cancer cells through regulating the ROS/AMPK/mTOR pathway	4
Therapeutic potential and mechanism of Chinese herbal medicines in treating fibrotic liver disease	4
Wenxia Changfu Formula inhibits NSCLC metastasis by halting TAMs-induced epithelial-mesenchymal transition via antagonisticallymodulating CCL18	4
Paeoniflorin alleviates depression by inhibiting the activation of NLRP3 inflammasome via promoting mitochondrial autophagy	4
Discovery of antitumor diterpenoids from Casearia graveolens targeting VEGFR-2 to inhibit angiogenesis	3
New prenylated flavonoid glycosides derived from Epimedium wushanense by β-glucosidase hydrolysis and their testosterone production-promoting effects	3
Macrocyclic trichothecenes from Myrothecium verrucaria PA 57 and their cytotoxic activity	3
Deciphering chemical and metabolite profiling of Chang-Kang-Fang by UPLC-Q-TOF-MS/MS and its potential active components identification	3
Functional characterization of CYP81C16 involved in the tanshinone biosynthetic pathway in Salvia miltiorrhiza	3
Er-xian ameliorates myocardial ischemia-reperfusion injury in rats through RISK pathway involving estrogen receptors	3
Potassium dehydroandrographolide succinate regulates the MyD88/CDH13 signaling pathway to enhance vascular injury-induced pathological vascular remodeling	3
Five new meroterpenoids from Rhododendron anthopogonoides and their anti-inflammatory activity	3
The combination of EGCG with warfarin reduces deep vein thrombosis in rabbits through modulating HIF-1α and VEGF via the PI3K/AKT and ERK1/2 signaling pathways	3
Puerarin inhibits inflammation and lipid accumulation in alcoholic liver disease through regulating MMP8	3
Natural medicine can substitute antibiotics in animal husbandry: protective effects and mechanisms of rosewood essential oil against Salmonella infection	3
Luteoloside protects the vascular endothelium against iron overload injury via the ROS/ADMA/DDAH II/eNOS/NO pathway	3
Rapid identification of stigmastane-type steroid saponins from Vernonia amygdalina leaf based on α-glucosidase inhibiting activity and molecular networking	3
New acylphloroglucinol-sesquiterpenoid adducts with antiviral activities from Dryopteris atrata	3
Combining label-free quantitative proteomics and 2D-DIGE to identify the potential targets of Sini Decoction acting on myocardial infarction	3
Molecular cloning and characterization of three phenylalanine ammonia-lyase genes from Schisandra chinensis	3
Combination strategies for first-line treatment of patients with unresectable hepatocellular carcinoma: prospect of natural products	3
A naturally derived small molecule compound suppresses tumor growth and metastasis in mice by relieving p53-dependent repression of CDK2/Rb signaling and the Snail-driven EMT	3
Sinkihwan-gamibang ameliorates puromycin aminonucleoside-induced nephrotic syndrome	3
Evaluation of pharmacokinetics and metabolism of three marine-derived piericidins for guiding drug lead selection	3
Heterologous production of bioactive xenoacremone analogs in Aspergillus nidulans	3
Discovery and bioassay of disubstituted β-elemene-NO donor conjugates: synergistic enhancement in the treatment of leukemia	3
Genome mining of fungal globin-like enzymes for catalyzing the synthesis of linear terpenes	3
Advances in the combination of stem cell exosomes with medical devices-the new direction for combination products	3
Jujuboside A inhibits oxidative stress damage and enhances immunomodulatory capacity of human umbilical cord mesenchymal stem cells through up-regulating IDO expression	3
New anti-pulmonary fibrosis prenylflavonoid glycosides from Epimedium koreanum	3
The biologically and ecologically important natural products from the Chinese sea hare Bursatella leachii: structures, stereochemistry and beyond	3
Traditional Chinese medicine enables the development of small-molecule inhibitors of HSP47, future therapeutic implication in venous thromboembolism	3
Advances in the role of natural products in human gene expression	3
Asponchimides A−E: new enantiomeric N-acetyldopamine trimers from Aspongopus chinensis	3
Geranylated or prenylated flavonoids from Cajanus volubilis	3
Comprehensive analysis of the antibacterial activity of 5,8-dihydroxy-1,4-naphthoquinone derivatives against methicillin-resistant Staphylococcus aureus	3
Deep chemical identification of phytoecdysteroids in Achyranthes bidentata Blume by UHPLC coupled with linear ion trap-Orbitrap mass spectrometry and targeted isolation	3
Research progress on naturally-occurring and semi-synthetic ocotillol-type ginsenosides in the genus Panax L. (Araliaceae)	3
A review of structural modification and biological activities of oleanolic acid	3