OOIR: Observatory of International Research

Papers

(The TQCC of Chinese Journal of Natural Medicines is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Ephedra Herb extract ameliorates adriamycin-induced nephrotic syndrome in rats via the CAMKK2/AMPK/mTOR signaling pathway	92
Targeting the biological activity and biosynthesis of hyperforin: a mini-review	48
Natural-derived drug carriers (NDDCs) for precision therapy	18
Immunomodulatory effects of flazin from Crassostrea sikamea on splenic lymphocytes of Sprague-Dawley rats	18
Bavachin induces apoptosis in colorectal cancer cells through Gadd45a via the MAPK signaling pathway	15
Dendrobium nobile protects against ovalbumin-induced allergic rhinitis by regulating intestinal flora and suppressing lung inflammation	15
Dihydroartemisinin attenuates ischemia/reperfusion-induced renal tubular senescence by activating autophagy	13
Repurposing diacerein to suppress colorectal cancer growth by inhibiting the DCLK1/STAT3 signaling pathway	13
Design and synthesis of novel saponin-triazole derivatives in the regulation of adipogenesis	13
Covalent flavoproteins: types, occurrence, biogenesis and catalytic mechanisms	12
Neutrophil CC1 plays a protective role in orthotopic liver transplantation: views from the perspective of natural compounds	12
Five Rutaceae family ethanol extracts alleviate H2O2 and LPS-induced inflammation via NF-κB and JAK-STAT3 pathway in HaCaT cells	11
Pure drug nanomedicines - where we are?	11
Ginsenoside Rb1 improves brain, lung, and intestinal barrier damage in middle cerebral artery occlusion/reperfusion (MCAO/R) micevia the PPARγ signaling pathway	10
Glasesterterpenoids A−C: three sesterterpenoids with 7-cyclohexyldecahydronaphthalene carbon skeleton isolated from the root of Lindera glauca	10
Progress in approved drugs from natural product resources	9
New di-spirocyclic labdane diterpenoids from the aerial parts of Leonurus japonicus	9
A CYP80B enzyme from Stephania tetrandra enables the 3'-hydroxylation of N-methylcoclaurine and coclaurine in the biosynthesis of benzylisoquinoline alkaloids	9
Metabolomics analysis reveals the renal protective effect of Panax ginseng C. A. Mey in type 1 diabetic rats	9
Anti-cancer and anti-inflammatory effects of flavan-4-ol and flavan glycosides from the roots of Pronephrium penangianum	9
Identification of Andrographis Herba and its common products using mini-barcode	9
Inonotus obliquus (Chaga) against HFD/STZ-induced glucolipid metabolism disorders and abnormal renal functions by regulating NOS-cGMP-PDE5 signaling pathway	9
Bear bile powder attenuates senecionine-induced hepatic sinusoidal obstruction syndrome in mice	8
Neuroprotective and antidiabetic lanostane-type triterpenoids from the fruiting bodies of Ganoderma theaecolum	8
Five new terpenoids from Viburnum odoratissimum var. sessiliflorum	8

Talaketides A−G, linear polyketides with prostate cancer cytotoxic activity from the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41027	8
Guijiajiao (Colla Carapacis et Plastri, CCP) prevents male infertility via gut microbiota modulation	8
Transdermal delivery of natural products against atopic dermatitis	8
Ginkgo biloba extract protects against depression-like behavior in mice through regulating gut microbial bile acid metabolism	8
Dahuang Zhechong pills inhibit liver cancer growth in a mouse model by reversing Treg/Th1 balance	8
Discovery of Eucalyptin C, derived from the fruits of Eucalyptus globulus Labill., as a novel selective PI3Kγ inhibitor for immunosuppressive treatment	8
De novo production of 24-epi-ergosterol in bioengineered yeast	8
Potential role of the protein interactome in translating TCM theory and clinical practice into modern biomedical knowledge	7
Discovery of fernane-type triterpenoids from Diaporthe discoidispora using genome mining and HSQC-based SMART technology	7
Eudesmane-guaiane sesquiterpenoid dimers from Aucklandia costus trigger paraptosis-like cell death via ROS accumulation and MAPK hyperactivation	7
Dimeric sesquiterpenoids with anti-inflammatory activities from Inula britannica	7
Study on the dynamic variation of the secondary metabolites in Viscum coloratum using targeted metabolomics	7
Stem-leaf saponins of Panax notoginseng attenuate experimental Parkinson's disease progression in mice by inhibiting microglia-mediated neuroinflammation via P2Y2R/PI3K/AKT/NFκB signaling pathway	7
The chemical structures, biosynthesis, and biological activities of secondary metabolites from the culinary-medicinal mushrooms of the genus Hericium: a review	7
Saponins from Aralia taibaiensis protect against brain ischemia/reperfusion injuries by regulating the apelin/AMPK pathway	7
Four new diphenyl ether derivatives from a mangrove endophytic fungus Epicoccum sorghinum	7
First-in-class drug oroxylin A tablets for treating hepatic and gastrointestinal disorders: from preclinical development to clinical research	7
Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo	7
New pimarane diterpenoids with antibacterial activity from fungus Arthrinium sp. ZS03	6
Anti-hepatitis B virus activities of natural products and their antiviral mechanisms	6
Structure-guided isolation of anti-neuroinflammatory sesquiterpene coumarins from Ferula sinkiangensis	6
EGCG and ECG induce apoptosis and decrease autophagy via the AMPK/mTOR and PI3K/AKT/mTOR pathway in human melanoma cells	6
Bioactive neolignans and lignans from the roots of Paeonia lactiflora	6
Rehmanniae Radix Praeparata aqueous extract improves hepatic ischemia/reperfusion injury by restoring intracellular iron homeostasis	6
Esculetin triggers ferroptosis via inhibition of the Nrf2-xCT/GPx4 axis in hepatocellular carcinoma	6
Anti-inflammatory effects of aucubin in cellular and animal models of rheumatoid arthritis	6
SBC (Sanhuang Xiexin Tang combined with Baihu Tang plus Cangzhu) alleviates NAFLD by enhancing mitochondrial biogenesis and ameliorating inflammation in obese patients and mice	6
Antimicrobial indole alkaloids from Tabernaemontana corymbosa	6
Cytotoxic lignans from the roots and rhizomes of Diphylleia sinensis, a China’s endemic plant species	6
Natural diosmin alleviating obesity and nonalcoholic fatty liver disease by regulating the activating the AMP-activated protein kinase (AMPK) pathway	6
Dammarane-type triterpenoid saponins isolated from Gynostemma pentaphyllum ameliorate liver fibrosis via agonizing PP2Cα and inhibiting deposition of extracellular matrix	6
The anti-neoplastic activities of aloperine in HeLa cervical cancer cells are associated with inhibition of the IL-6-JAK1-STAT3 feedback loop	6
Intervention of natural products targeting novel mechanisms after myocardial infarction	6
Artemdubinoids A–N: novel sesquiterpenoids with antihepatoma cytotoxicity from Artemisia dubia	6
Thirteen new peptaibols with antimicrobial activities from Trichoderma sp.	6
NO inhibitory constituents from Glycosmis craibii var. glabra	5
10,11-Dehydrocurvularin attenuates inflammation by suppressing NLRP3 inflammasome activation	5
A comprehensive review of natural products with anti-hypoxic activity	5
Korean red ginseng alleviates benign prostatic hyperplasia by dysregulating androgen receptor signaling and inhibiting DRP1-mediated mitochondrial fission	5
Anti-inflammatory germacrane-type sesquiterpene lactones from Vernonia sylvatica	5
Exosomes derived from Nr-CWS pretreated MSCs facilitate diabetic wound healing by promoting angiogenesis via the circIARS1/miR-4782-5p/VEGFA axis	5
Five new spirosterol saponins from Allii Macrostemonis Bulbus	5
Diverse sesquiterpenoids from Litsea lancilimba Merr. with potential neuroprotective effects against H2O2-induced SH-SY5Y cell injury	5
A comprehensive review on wedelolactone: natural sources, total synthesis, and pharmacological activities	5
Taohong Siwu Decoction: a classical Chinese prescription for treatment of orthopedic diseases	5
Therapeutic potential and mechanism of Chinese herbal medicines in treating fibrotic liver disease	5
Chemical composition-based characterization of the anti-allergic effect of Guominkang Formula on IgE-mediated mast cells activation and passive cutaneous anaphylaxis	5
Heme peroxidases are responsible for the dehydrogenation and oxidation metabolism of harmaline into harmine	5
Physalin B reduces Aβ secretion through down-regulation of BACE1 expression by activating FoxO1 and inhibiting STAT3 phosphorylation	5
Anti-pseudo-allergic components in licorice extract inhibit mast cell degranulation and calcium influx	5

Abietane diterpenoids and iridoids from Caryopteris mongolica	5
Investigation of the metabolites of five major constituents from Berberis amurensis in normal and pseudo germ-free rats	5
Wenxia Changfu Formula inhibits NSCLC metastasis by halting TAMs-induced epithelial-mesenchymal transition via antagonisticallymodulating CCL18	5
Geranylated or prenylated flavonoids from Cajanus volubilis	4
Integrative SMRT sequencing and ginsenoside profiling analysis provide insights into the biosynthesis of ginsenoside in Panax quinquefolium	4
NUMB endocytic adaptor protein (NUMB) mediates the anti-hepatic fibrosis effect of artesunate (ART) by inducing senescence in hepatic stellate cells (HSCs)	4
Sulfite as the substrate of C-sulfonate metabolism of α, β-unsaturated carbonyl containing andrographolide: analysis of sulfite in rats' intestinal tract and the reaction kinetics of andrographolide w	4
Paeoniflorin alleviates depression by inhibiting the activation of NLRP3 inflammasome via promoting mitochondrial autophagy	4
Commentary on “A population of stem cells with strong regenerative potential discovered in deer antlers ”	4
Loganin inhibits the ROS-NLRP3-IL-1β axis by activating the NRF2/HO-1 pathway against osteoarthritis	4
Comprehensive analysis of the antibacterial activity of 5,8-dihydroxy-1,4-naphthoquinone derivatives against methicillin-resistant Staphylococcus aureus	4
Potassium dehydroandrographolide succinate regulates the MyD88/CDH13 signaling pathway to enhance vascular injury-induced pathological vascular remodeling	4
Xanthones from Garcinia pedunculata and Garcinia nujiangensis and their anti-inflammatory activity	4
Structurally diverse sesquiterpenoids with anti-MDR cancer activity from Penicillium roqueforti	4
New nor-ent-halimane and nor-clerodane diterpenes from Callicarpa integerrima with anti-MRSA activity	4
Nigella sativa L. seed extract alleviates oxidative stress-induced cellular senescence and dysfunction in melanocytes	4
Eucommia lignans alleviate the progression of diabetic nephropathy through mediating the AR/Nrf2/HO-1/AMPK axis in vivo and in vitro	4
Ginsenoside-Rg1 combined with a conditioned medium from induced neuron-like hUCMSCs alleviated the apoptosis in a cell model of ALS through regulating the NF-κB/Bcl-2 pathway	4
β-Elemene induces apoptosis and autophagy in colorectal cancer cells through regulating the ROS/AMPK/mTOR pathway	4
Geranyl phenyl ethers from Illicium micranthum and their anti-HBV activity	4
Houttuynia cordata polysaccharides alleviate ulcerative colitis by restoring intestinal homeostasis	4
Natural ingredients from Chinese materia medica for pulmonary hypertension	4
Herbal medicines for insomnia through regulating 5-hydroxytryptamine receptors: a systematic review	4
Protective effects of Wuwei Xiaodu Drink against chronic osteomyelitis through Foxp3+CD25+CD4+ Treg cells via the IL-2/STAT5 signaling pathway	4
Potential role of Natural Herbal Tea as a healthy beverage in reducing the risk of liver cancer and chronic liver disease mortality	4
Pinelliae Rhizoma: a systematic review on botany, ethnopharmacology, phytochemistry, preclinical and clinical evidence	4
Molecular cloning and functional characterization of an isoflavone glucosyltransferase from Pueraria thomsonii	4
The combination of EGCG with warfarin reduces deep vein thrombosis in rabbits through modulating HIF-1α and VEGF via the PI3K/AKT and ERK1/2 signaling pathways	4