OOIR: Observatory of International Research

Papers

(The TQCC of Chinese Journal of Natural Medicines is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Design and synthesis of novel saponin-triazole derivatives in the regulation of adipogenesis	110
Natural-derived drug carriers (NDDCs) for precision therapy	64
Dihydroartemisinin attenuates ischemia/reperfusion-induced renal tubular senescence by activating autophagy	22
Targeting the biological activity and biosynthesis of hyperforin: a mini-review	18
Bavachin induces apoptosis in colorectal cancer cells through Gadd45a via the MAPK signaling pathway	17
Multidrug resistance reversal effect of tenacissoside I through impeding EGFR methylation mediated by PRMT1 inhibition	17
Ephedra Herb extract ameliorates adriamycin-induced nephrotic syndrome in rats via the CAMKK2/AMPK/mTOR signaling pathway	16
Dendrobium nobile protects against ovalbumin-induced allergic rhinitis by regulating intestinal flora and suppressing lung inflammation	16
Glasesterterpenoids A−C: three sesterterpenoids with 7-cyclohexyldecahydronaphthalene carbon skeleton isolated from the root of Lindera glauca	14
Inonotus obliquus (Chaga) against HFD/STZ-induced glucolipid metabolism disorders and abnormal renal functions by regulating NOS-cGMP-PDE5 signaling pathway	13
A CYP80B enzyme from Stephania tetrandra enables the 3'-hydroxylation of N-methylcoclaurine and coclaurine in the biosynthesis of benzylisoquinoline alkaloids	13
Ginsenoside Rb1 improves brain, lung, and intestinal barrier damage in middle cerebral artery occlusion/reperfusion (MCAO/R) micevia the PPARγ signaling pathway	12
Repurposing diacerein to suppress colorectal cancer growth by inhibiting the DCLK1/STAT3 signaling pathway	12
Neutrophil CC1 plays a protective role in orthotopic liver transplantation: views from the perspective of natural compounds	12
Research progress on new techniques and methods for identifying active ingredients in traditional Chinese medicine	10
Taohe Chengqi decoction inhibits PAD4-mediated neutrophil extracellular traps and mitigates acute lung injury induced by sepsis	10
New di-spirocyclic labdane diterpenoids from the aerial parts of Leonurus japonicus	10
Anti-cancer and anti-inflammatory effects of flavan-4-ol and flavan glycosides from the roots of Pronephrium penangianum	9
Progress in approved drugs from natural product resources	9
Metabolomics analysis reveals the renal protective effect of Panax ginseng C. A. Mey in type 1 diabetic rats	9
Ginkgo biloba extract protects against depression-like behavior in mice through regulating gut microbial bile acid metabolism	9
Covalent flavoproteins: types, occurrence, biogenesis and catalytic mechanisms	9
TSZAF monomer combination downregulates the Wnt/β-catenin signaling pathway and inhibits neutrophil recruitment to prevent lung cancer metastasis	9
De novo production of 24-epi-ergosterol in bioengineered yeast	9
Identification of Andrographis Herba and its common products using mini-barcode	9

Pure drug nanomedicines - where we are?	9
Five Rutaceae family ethanol extracts alleviate H2O2 and LPS-induced inflammation via NF-κB and JAK-STAT3 pathway in HaCaT cells	9
Guijiajiao (Colla Carapacis et Plastri, CCP) prevents male infertility via gut microbiota modulation	9
Identification of natural product-based drug combination (NPDC) using artificial intelligence	8
Natural products targeting NLRP3 inflammasome for metabolic dysfunction-associated fatty liver disease: the known unknowns	8
Transdermal delivery of natural products against atopic dermatitis	8
Five new terpenoids from Viburnum odoratissimum var. sessiliflorum	8
Dimeric sesquiterpenoids with anti-inflammatory activities from Inula britannica	8
Neuroprotective and antidiabetic lanostane-type triterpenoids from the fruiting bodies of Ganoderma theaecolum	8
Potential role of the protein interactome in translating TCM theory and clinical practice into modern biomedical knowledge	8
Talaketides A−G, linear polyketides with prostate cancer cytotoxic activity from the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41027	8
Stem-leaf saponins of Panax notoginseng attenuate experimental Parkinson's disease progression in mice by inhibiting microglia-mediated neuroinflammation via P2Y2R/PI3K/AKT/NFκB signaling pathway	7
Bear bile powder attenuates senecionine-induced hepatic sinusoidal obstruction syndrome in mice	7
Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo	7
Discovery of fernane-type triterpenoids from Diaporthe discoidispora using genome mining and HSQC-based SMART technology	7
Study on the dynamic variation of the secondary metabolites in Viscum coloratum using targeted metabolomics	7
Four new diphenyl ether derivatives from a mangrove endophytic fungus Epicoccum sorghinum	7
First-in-class drug oroxylin A tablets for treating hepatic and gastrointestinal disorders: from preclinical development to clinical research	7
Cytotoxic lignans from the roots and rhizomes of Diphylleia sinensis, a China’s endemic plant species	7
Dahuang Zhechong pills inhibit liver cancer growth in a mouse model by reversing Treg/Th1 balance	7
The chemical structures, biosynthesis, and biological activities of secondary metabolites from the culinary-medicinal mushrooms of the genus Hericium: a review	7
Saponins from Aralia taibaiensis protect against brain ischemia/reperfusion injuries by regulating the apelin/AMPK pathway	7
Artemdubinoids A–N: novel sesquiterpenoids with antihepatoma cytotoxicity from Artemisia dubia	6
Structurally diverse terpenoids from Pseudotsuga brevifolia and their inhibitory effects against ACL and ACC1 enzymes	6
Antimicrobial indole alkaloids from Tabernaemontana corymbosa	6
SBC (Sanhuang Xiexin Tang combined with Baihu Tang plus Cangzhu) alleviates NAFLD by enhancing mitochondrial biogenesis and ameliorating inflammation in obese patients and mice	6
Natural diosmin alleviating obesity and nonalcoholic fatty liver disease by regulating the activating the AMP-activated protein kinase (AMPK) pathway	6
Eudesmane-guaiane sesquiterpenoid dimers from Aucklandia costus trigger paraptosis-like cell death via ROS accumulation and MAPK hyperactivation	6
Bioactive neolignans and lignans from the roots of Paeonia lactiflora	6
Rehmanniae Radix Praeparata aqueous extract improves hepatic ischemia/reperfusion injury by restoring intracellular iron homeostasis	6
Dammarane-type triterpenoid saponins isolated from Gynostemma pentaphyllum ameliorate liver fibrosis via agonizing PP2Cα and inhibiting deposition of extracellular matrix	6
EGCG and ECG induce apoptosis and decrease autophagy via the AMPK/mTOR and PI3K/AKT/mTOR pathway in human melanoma cells	6
Thirteen new peptaibols with antimicrobial activities from Trichoderma sp.	6
Intervention of natural products targeting novel mechanisms after myocardial infarction	6
Anti-hepatitis B virus activities of natural products and their antiviral mechanisms	6
Wenxia Changfu Formula inhibits NSCLC metastasis by halting TAMs-induced epithelial-mesenchymal transition via antagonisticallymodulating CCL18	5
TCM network pharmacology: new perspective integrating network target with artificial intelligence and multi-modal multi-omics technologies	5
Chemical composition-based characterization of the anti-allergic effect of Guominkang Formula on IgE-mediated mast cells activation and passive cutaneous anaphylaxis	5
A comprehensive review of natural products with anti-hypoxic activity	5
NO inhibitory constituents from Glycosmis craibii var. glabra	5
Anti-inflammatory effects of aucubin in cellular and animal models of rheumatoid arthritis	5
Five new spirosterol saponins from Allii Macrostemonis Bulbus	5
Anti-pseudo-allergic components in licorice extract inhibit mast cell degranulation and calcium influx	5
Paeoniflorin alleviates depression by inhibiting the activation of NLRP3 inflammasome via promoting mitochondrial autophagy	5
Exosomes derived from Nr-CWS pretreated MSCs facilitate diabetic wound healing by promoting angiogenesis via the circIARS1/miR-4782-5p/VEGFA axis	5
Taohong Siwu Decoction: a classical Chinese prescription for treatment of orthopedic diseases	5
Abietane diterpenoids and iridoids from Caryopteris mongolica	5
Leveraging microbial natural products for pharmaceutical innovation: a vision of inspiration and future prospects	5
KG-CNNDTI: a knowledge graph-enhanced prediction model for drug-target interactions and application in virtual screening of natural products against Alzheimer’s disease	5
Heme peroxidases are responsible for the dehydrogenation and oxidation metabolism of harmaline into harmine	5

Esculetin triggers ferroptosis via inhibition of the Nrf2-xCT/GPx4 axis in hepatocellular carcinoma	5
Anti-inflammatory germacrane-type sesquiterpene lactones from Vernonia sylvatica	5
Therapeutic potential and mechanism of Chinese herbal medicines in treating fibrotic liver disease	5
Ginsenoside-Rg1 combined with a conditioned medium from induced neuron-like hUCMSCs alleviated the apoptosis in a cell model of ALS through regulating the NF-κB/Bcl-2 pathway	5
Eucommia lignans alleviate the progression of diabetic nephropathy through mediating the AR/Nrf2/HO-1/AMPK axis in vivo and in vitro	5
10,11-Dehydrocurvularin attenuates inflammation by suppressing NLRP3 inflammasome activation	5
Diverse sesquiterpenoids from Litsea lancilimba Merr. with potential neuroprotective effects against H2O2-induced SH-SY5Y cell injury	5
New pimarane diterpenoids with antibacterial activity from fungus Arthrinium sp. ZS03	5
A comprehensive review on wedelolactone: natural sources, total synthesis, and pharmacological activities	5
Structure-guided isolation of anti-neuroinflammatory sesquiterpene coumarins from Ferula sinkiangensis	5
β-Elemene induces apoptosis and autophagy in colorectal cancer cells through regulating the ROS/AMPK/mTOR pathway	4
Commentary on “A population of stem cells with strong regenerative potential discovered in deer antlers ”	4
Evaluation of pharmacokinetics and metabolism of three marine-derived piericidins for guiding drug lead selection	4
Exploring artificial intelligence approaches for predicting synergistic effects of active compounds in traditional Chinese medicine based on molecular compatibility theory	4
Heterologous production of bioactive xenoacremone analogs in Aspergillus nidulans	4
Puerarin inhibits inflammation and lipid accumulation in alcoholic liver disease through regulating MMP8	4
The combination of EGCG with warfarin reduces deep vein thrombosis in rabbits through modulating HIF-1α and VEGF via the PI3K/AKT and ERK1/2 signaling pathways	4
New nor-ent-halimane and nor-clerodane diterpenes from Callicarpa integerrima with anti-MRSA activity	4
Herbal medicines for insomnia through regulating 5-hydroxytryptamine receptors: a systematic review	4
Potential role of Natural Herbal Tea as a healthy beverage in reducing the risk of liver cancer and chronic liver disease mortality	4
Comprehensive analysis of the antibacterial activity of 5,8-dihydroxy-1,4-naphthoquinone derivatives against methicillin-resistant Staphylococcus aureus	4
Five new meroterpenoids from Rhododendron anthopogonoides and their anti-inflammatory activity	4
Sinkihwan-gamibang ameliorates puromycin aminonucleoside-induced nephrotic syndrome	4
Geranyl phenyl ethers from Illicium micranthum and their anti-HBV activity	4
Loganin inhibits the ROS-NLRP3-IL-1β axis by activating the NRF2/HO-1 pathway against osteoarthritis	4
Geranylated or prenylated flavonoids from Cajanus volubilis	4
Nigella sativa L. seed extract alleviates oxidative stress-induced cellular senescence and dysfunction in melanocytes	4
Structurally diverse sesquiterpenoids with anti-MDR cancer activity from Penicillium roqueforti	4
Korean red ginseng alleviates benign prostatic hyperplasia by dysregulating androgen receptor signaling and inhibiting DRP1-mediated mitochondrial fission	4
Protective effects of Wuwei Xiaodu Drink against chronic osteomyelitis through Foxp3+CD25+CD4+ Treg cells via the IL-2/STAT5 signaling pathway	4
Pinelliae Rhizoma: a systematic review on botany, ethnopharmacology, phytochemistry, preclinical and clinical evidence	4
Integrative SMRT sequencing and ginsenoside profiling analysis provide insights into the biosynthesis of ginsenoside in Panax quinquefolium	4
Potassium dehydroandrographolide succinate regulates the MyD88/CDH13 signaling pathway to enhance vascular injury-induced pathological vascular remodeling	4
Molecular cloning and functional characterization of an isoflavone glucosyltransferase from Pueraria thomsonii	4
MolP-PC: a multi-view fusion and multi-task learning framework for drug ADMET property prediction	4
Xanthones from Garcinia pedunculata and Garcinia nujiangensis and their anti-inflammatory activity	4
NUMB endocytic adaptor protein (NUMB) mediates the anti-hepatic fibrosis effect of artesunate (ART) by inducing senescence in hepatic stellate cells (HSCs)	4