OOIR: Observatory of International Research

Papers

(The median citation count of Inflammation and Regeneration is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Macrophage depletion in inflamed rat knees prevents the activation of synovial mesenchymal stem cells by weakening Nampt and Spp1 signaling	156
Beyond the bulk: overview and novel insights into the dynamics of muscle satellite cells during muscle regeneration	129
Single-pixel imaging flow cytometry for biomedical research	96
Jdp2 is a spatiotemporal transcriptional activator of the AhR via the Nrf2 gene battery	88
Ability to form Sox17-induced hematopoietic cell clusters varies among distinct hematopoietic sites during development	81
Ca2+ microdomain-based excitation-transcription coupling in cardiac myocytes and vascular smooth muscle cells	72
Molecular mechanism of crosstalk between immune and metabolic systems in metabolic syndrome	69
Peripheral and central regulation of neuro–immune crosstalk	69
APJ regulates the balance between self-renewal and differentiation of vascular endothelial stem cells	63
Umbilical cord blood and cord tissue banking as somatic stem cell resources to support medical cell modalities	62
Preadipocytes in human granulation tissue: role in wound healing and response to macrophage polarization	49
Correction: Autoinflammatory disease: clinical perspectives and therapeutic strategies	47
Cross-talk between nervous, immune, and metabolic systems	45
Organization of self-advantageous niche by neural stem/progenitor cells during development via autocrine VEGF-A under hypoxia	44
Analysis of distribution, collection, and confirmation of capacity dependency of small extracellular vesicles toward a therapy for liver cirrhosis	44
Extracellular vesicles from immortalized mesenchymal stromal cells protect against neonatal hypoxic-ischemic brain injury	41
Acomys cahirinus develop lung stroma distortion but not fibrosis after bleomycin-induced injury	39
Adaptive-like CAR-iPSC-CD4⁺ T cells outperform CD8⁺ counterparts in sustained ALL control	38
IFN-γ-STAT1-mediated CD8+ T-cell-neural stem cell cross talk controls astrogliogenesis after spinal cord injury	35
Immune cell trafficking: a novel perspective on the gut-skin axis	35
Transcutaneous auricular vagus nerve stimulation promotes recovery from otitis media by activating the α7nAChR-mediated anti-inflammatory pathway	34
In vivo imaging of inflammatory response in cancer research	33
Promotion of axon regeneration and protection on injured retinal ganglion cells by rCXCL2	32
Recent advances in immunological mechanisms and murine disease models of idiopathic inflammatory myopathies	31
Rapid and high-purity differentiation of human medium spiny neurons reveals LMNB1 hypofunction and subtype necessity in modeling Huntington’s disease	31

Cytokines and cytokine receptors as targets of immune-mediated inflammatory diseases—RA as a role model	30
Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation	30
A lesion-selective albumin-CTLA4Ig as a safe and effective treatment for collagen-induced arthritis	29
Novel artificial nerve transplantation of human iPSC-derived neurite bundles enhanced nerve regeneration after peripheral nerve injury	29
Enhanced nerve regeneration after transplantation of NCAM-positive neural crest-like cells derived from human iPSC	28
Adipose-derived mesenchymal stem cell therapy for connective tissue diseases and complications	28
Pathophysiological functions of semaphorins in the sympathetic nervous system	28
Innate immune recognition against SARS-CoV-2	28
Accelerating corneal wound healing using exosome-mediated targeting of NF-κB c-Rel	26
Autoinflammatory disease: clinical perspectives and therapeutic strategies	26
Quercetin enhances survival and axonal regeneration of motoneurons after spinal root avulsion and reimplantation: experiments in a rat model of brachial plexus avulsion	26
Par2-mediated responses in inflammation and regeneration: choosing between repair and damage	25
Senescence of T cells and organ aging	25
Advances in vascular endothelial cell-mediated regulation of satellite cell repair and regeneration	23
Role of the Hippo pathway in liver regeneration and repair: recent advances	23
A human induced pluripotent stem cell model from a patient with hereditary cerebral small vessel disease carrying a heterozygous R302Q mutation in HTRA1	23
Destruction and regeneration in bone and cartilage	23
Genome editing iPSC to purposing enhancement of induce CD8 killer T cell function for regenerative immunotherapy	22
Characterization of the human gut virome in metabolic and autoimmune diseases	21
From bench to bedside: the role of gastrointestinal stem cells in health and disease	21
Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia	20
Stem cell-based drug delivery strategy for skin regeneration and wound healing: potential clinical applications	20
Epigenetic targets of Janus kinase inhibitors are linked to genetic risks of rheumatoid arthritis	19
Effects of intranasal long-acting insulin pretreatment on postoperative delirium and the NLRP3/caspase-1/IL-1β pathway in older patients with esophageal cancer	19
Innate immune memory in macrophage differentiation and cardiovascular diseases	18
Reengineering statin therapy to protect skeletal muscle: nanocarrier strategies for mitigating mitochondrial dysfunction and myotoxicity	18
Functional diversity of disorder-specific macrophages involved in various diseases	18
Th22 is the effector cell of thymosin β15-induced hair regeneration in mice	18
Hippo pathway in cell–cell communication: emerging roles in development and regeneration	17
Intravital imaging of immune responses in intestinal inflammation	17
NRP2+ human mesenchymal stem cells have stemness-associated properties	16
Research hotspots and trends for axon regeneration (2000–2021): a bibliometric study and systematic review	16
A review of current status of cell-based therapies for aortic aneurysms	16
A disease-specific iPS cell resource for studying rare and intractable diseases	16
Targeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer’s disease	15
Human PBMC-based humanized mice exhibit myositis features and serve as a drug evaluation model	15
Harnessing the potential of gene editing technology for CAR-T cell therapy of solid tumors	15
Potential therapeutic applications of stem cells in animal models of ocular affections	15
Helicobacter pylori infection in the stomach induces neuroinflammation: the potential roles of bacterial outer membrane vesicles in an animal model of Alzheimer’s disease	15
Clinical perspectives and therapeutic strategies: pediatric autoinflammatory disease—a multi-faceted approach to fever of unknown origin of childhood	15
Cartilage evaluation by ultrasonography in patients with rheumatoid arthritis: a scoping review	15
Anti-survival of motor neuron antibodies in rheumatic and musculoskeletal diseases: prevalence, clinical associations, and biomarker potential, with novel insights into disease activity in SLE	15
Cellular niches for hematopoietic stem cells in bone marrow under normal and malignant conditions	15
Cancer ego-system in glioma: an iron-replenishing niche network systemically self-organized by cancer stem cells	15
Chronological transitions of hepatocyte growth factor treatment effects in spinal cord injury tissue	15
Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice	15
SPARC activates p38γ signaling to promote PFKFB3 protein stabilization and contributes to keloid fibroblast glycolysis	14
Canonical Wnt signaling activation by chimeric antigen receptors for efficient cardiac differentiation from mouse embryonic stem cells	14
Regeneration of invariant natural killer T (iNKT) cells: application of iPSC technology for iNKT cell-targeted tumor immunotherapy	14
The oral-gut axis: a missing piece in the IBD puzzle	14

Ex vivo lung-organoid model for aberrant basaloid cell induction and activation	13
Significance of the multiomics approach to elucidate disease mechanisms in humans	13
Versatile extracellular vesicle-mediated information transfer: intercellular synchronization of differentiation and of cellular phenotypes, and future perspectives	13
Testosterone upregulates glial cell line-derived neurotrophic factor (GDNF) and promotes neuroinflammation to enhance glioma cell survival and proliferation	13
Diagnostic potential of cryptic exon-derived peptides in serum extracellular vesicles for sporadic amyotrophic lateral sclerosis	12
The role of Staphylococcus aureus quorum sensing in cutaneous and systemic infections	12
Next-generation proteomics of serum extracellular vesicles combined with single-cell RNA sequencing identifies MACROH2A1 associated with refractory COVID-19	12
Matrix remodeling associated 7 proteins promote cutaneous wound healing through vimentin in coordinating fibroblast functions	12
Arthritis-associated osteoclastogenic macrophage, AtoM, as a key player in pathological bone erosion	11
Inter-organ communication involved in metabolic regulation at the whole-body level	11
Enhancement of bone regeneration by coadministration of angiogenic and osteogenic factors using messenger RNA	11
Designer immune cells	11
Natural killer cells: gatekeepers of healthy aging in longevity medicine	11
Marine-derived microbes and molecules for drug discovery	11
Cell fusion dynamics: mechanisms of multinucleation in osteoclasts and macrophages	11
The impact of T cells on immune-related liver diseases: an overview	10
Microbiota-derived D-amino acids in intestinal homeostasis and inflammatory bowel disease	10
Multi-organ frailty is enhanced by periodontitis-induced inflammaging	10
Effect of JAK inhibitors on the three forms of bone damage in autoimmune arthritis: joint erosion, periarticular osteopenia, and systemic bone loss	10
CXCL10 deficiency limits macrophage infiltration, preserves lung matrix, and enables lung growth in bronchopulmonary dysplasia	10
Identification of molecular subtypes based on inflammatory response in lower-grade glioma	10
Osteoclast biology in the single-cell era	10
Recent advances in Raman probes for multiplexed bioimaging	10
Function of alveolar macrophages in lung cancer microenvironment	10
Pivotal contribution of super-enhancer-driven KLF6 expression to the adipogenesis of human adipose-derived stem cells	10
Dendritic cell heterogeneity and its role in connective tissue diseases	10
Extracellular vesicles from dental pulp mesenchymal stem cells modulate macrophage phenotype during acute and chronic cardiac inflammation in athymic nude rats with myocardial infarction	10
A novel cell-free intrathecal approach with PRP for the treatment of spinal cord multiple sclerosis in cats	10
Effect of aging on the formation and growth of colonic epithelial organoids by changes in cell cycle arrest through TGF-β-Smad3 signaling	10
Maternal immunoglobulins are distributed in the offspring’s brain to support the maintenance of cortical interneurons in the postnatal period	9
A spatiotemporal atlas of senescence-associated secretory phenotype in fracture healing: stage-dependent mechanisms and therapeutic windows	9
Amphiregulin attenuates sepsis-induced myocardial dysfunction by maintaining the localization of connexin43	9
The Ragulator complex: delving its multifunctional impact on metabolism and beyond	9
Duration of SARS-CoV-2 RNA positivity from various specimens and clinical characteristics in patients with COVID-19: a systematic review and meta-analysis	9
Atypical cholangiocytes derived from hepatocyte-cholangiocyte transdifferentiation mediated by COX-2: a kind of misguided liver regeneration	9
Optimization of transplantation methods using isolated mesenchymal stem/stromal cells: clinical trials of inflammatory bowel diseases as an example	9
Neuroplasticity related to chronic pain and its modulation by microglia	9