OOIR: Observatory of International Research

Papers

(The median citation count of Inflammation and Regeneration is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Macrophage depletion in inflamed rat knees prevents the activation of synovial mesenchymal stem cells by weakening Nampt and Spp1 signaling	166
Jdp2 is a spatiotemporal transcriptional activator of the AhR via the Nrf2 gene battery	116
Beyond the bulk: overview and novel insights into the dynamics of muscle satellite cells during muscle regeneration	95
Molecular mechanism of crosstalk between immune and metabolic systems in metabolic syndrome	69
Ca2+ microdomain-based excitation-transcription coupling in cardiac myocytes and vascular smooth muscle cells	63
Peripheral and central regulation of neuro–immune crosstalk	56
Cross-talk between nervous, immune, and metabolic systems	52
Correction: Autoinflammatory disease: clinical perspectives and therapeutic strategies	50
Preadipocytes in human granulation tissue: role in wound healing and response to macrophage polarization	49
Organization of self-advantageous niche by neural stem/progenitor cells during development via autocrine VEGF-A under hypoxia	41
Analysis of distribution, collection, and confirmation of capacity dependency of small extracellular vesicles toward a therapy for liver cirrhosis	40
Extracellular vesicles from immortalized mesenchymal stromal cells protect against neonatal hypoxic-ischemic brain injury	38
APJ regulates the balance between self-renewal and differentiation of vascular endothelial stem cells	38
Umbilical cord blood and cord tissue banking as somatic stem cell resources to support medical cell modalities	38
Immune cell trafficking: a novel perspective on the gut-skin axis	37
In vivo imaging of inflammatory response in cancer research	36
Acomys cahirinus develop lung stroma distortion but not fibrosis after bleomycin-induced injury	36
Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation	34
Rapid and high-purity differentiation of human medium spiny neurons reveals LMNB1 hypofunction and subtype necessity in modeling Huntington’s disease	30
Cytokines and cytokine receptors as targets of immune-mediated inflammatory diseases—RA as a role model	29
Novel artificial nerve transplantation of human iPSC-derived neurite bundles enhanced nerve regeneration after peripheral nerve injury	29
Molecular biology of autoinflammatory diseases	28
IFN-γ-STAT1-mediated CD8+ T-cell-neural stem cell cross talk controls astrogliogenesis after spinal cord injury	27
Adipose-derived mesenchymal stem cell therapy for connective tissue diseases and complications	27
Promotion of axon regeneration and protection on injured retinal ganglion cells by rCXCL2	27

Innate immune recognition against SARS-CoV-2	25
Pathophysiological functions of semaphorins in the sympathetic nervous system	25
Quercetin enhances survival and axonal regeneration of motoneurons after spinal root avulsion and reimplantation: experiments in a rat model of brachial plexus avulsion	25
Accelerating corneal wound healing using exosome-mediated targeting of NF-κB c-Rel	24
Autoinflammatory disease: clinical perspectives and therapeutic strategies	24
A lesion-selective albumin-CTLA4Ig as a safe and effective treatment for collagen-induced arthritis	23
Role of the Hippo pathway in liver regeneration and repair: recent advances	22
A human induced pluripotent stem cell model from a patient with hereditary cerebral small vessel disease carrying a heterozygous R302Q mutation in HTRA1	22
Par2-mediated responses in inflammation and regeneration: choosing between repair and damage	22
Destruction and regeneration in bone and cartilage	21
From bench to bedside: the role of gastrointestinal stem cells in health and disease	20
Epigenetic targets of Janus kinase inhibitors are linked to genetic risks of rheumatoid arthritis	20
A case of refractory systemic lupus erythematosus with monocytosis exhibiting somatic KRAS mutation	20
Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia	20
Characterization of the human gut virome in metabolic and autoimmune diseases	19
Genome editing iPSC to purposing enhancement of induce CD8 killer T cell function for regenerative immunotherapy	19
Stem cell-based drug delivery strategy for skin regeneration and wound healing: potential clinical applications	19
Generation of a BAC transgenic mouse strain that expresses CreERT and a fluorescent protein under the transcriptional control of the Fzd5 locus	18
A review of current status of cell-based therapies for aortic aneurysms	17
Intravital imaging of immune responses in intestinal inflammation	17
Hippo pathway in cell–cell communication: emerging roles in development and regeneration	17
Transition of clinical and basic studies on liver cirrhosis treatment using cells to seek the best treatment	16
Th22 is the effector cell of thymosin β15-induced hair regeneration in mice	16
Innate immune memory in macrophage differentiation and cardiovascular diseases	16
Cancer ego-system in glioma: an iron-replenishing niche network systemically self-organized by cancer stem cells	15
A disease-specific iPS cell resource for studying rare and intractable diseases	15
Clinical perspectives and therapeutic strategies: pediatric autoinflammatory disease—a multi-faceted approach to fever of unknown origin of childhood	15
Editorial: Towards a better understanding of the physiology of the lymphatics	15
NRP2+ human mesenchymal stem cells have stemness-associated properties	15
Chronological transitions of hepatocyte growth factor treatment effects in spinal cord injury tissue	14
Research hotspots and trends for axon regeneration (2000–2021): a bibliometric study and systematic review	14
A novel prostaglandin I2 agonist, ONO-1301, attenuates liver inflammation and suppresses fibrosis in non-alcoholic steatohepatitis model mice	14
Cartilage evaluation by ultrasonography in patients with rheumatoid arthritis: a scoping review	14
Human PBMC-based humanized mice exhibit myositis features and serve as a drug evaluation model	14
Potential therapeutic applications of stem cells in animal models of ocular affections	13
Helicobacter pylori infection in the stomach induces neuroinflammation: the potential roles of bacterial outer membrane vesicles in an animal model of Alzheimer’s disease	13
Cellular niches for hematopoietic stem cells in bone marrow under normal and malignant conditions	12
Targeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer’s disease	12
SPARC activates p38γ signaling to promote PFKFB3 protein stabilization and contributes to keloid fibroblast glycolysis	12
Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice	12
Significance of the multiomics approach to elucidate disease mechanisms in humans	11
The oral-gut axis: a missing piece in the IBD puzzle	11
Canonical Wnt signaling activation by chimeric antigen receptors for efficient cardiac differentiation from mouse embryonic stem cells	11
Marine-derived microbes and molecules for drug discovery	11
Genome-oriented treatment strategies for autoimmune diseases	11
Next-generation proteomics of serum extracellular vesicles combined with single-cell RNA sequencing identifies MACROH2A1 associated with refractory COVID-19	11
Regeneration of invariant natural killer T (iNKT) cells: application of iPSC technology for iNKT cell-targeted tumor immunotherapy	11
Testosterone upregulates glial cell line-derived neurotrophic factor (GDNF) and promotes neuroinflammation to enhance glioma cell survival and proliferation	11
Emerging roles of inflammation-mediated endothelial–mesenchymal transition in health and disease	10
Inter-organ communication involved in metabolic regulation at the whole-body level	10

Versatile extracellular vesicle-mediated information transfer: intercellular synchronization of differentiation and of cellular phenotypes, and future perspectives	10
Matrix remodeling associated 7 proteins promote cutaneous wound healing through vimentin in coordinating fibroblast functions	10
Designer immune cells	9
The role of Staphylococcus aureus quorum sensing in cutaneous and systemic infections	9
Enhancement of bone regeneration by coadministration of angiogenic and osteogenic factors using messenger RNA	9
Arthritis-associated osteoclastogenic macrophage, AtoM, as a key player in pathological bone erosion	9
Cell fusion dynamics: mechanisms of multinucleation in osteoclasts and macrophages	9
The impact of T cells on immune-related liver diseases: an overview	9
Multi-organ frailty is enhanced by periodontitis-induced inflammaging	9
Atypical cholangiocytes derived from hepatocyte-cholangiocyte transdifferentiation mediated by COX-2: a kind of misguided liver regeneration	8
Osteoclast biology in the single-cell era	8
Function of alveolar macrophages in lung cancer microenvironment	8
Effect of aging on the formation and growth of colonic epithelial organoids by changes in cell cycle arrest through TGF-β-Smad3 signaling	8
CXCL10 deficiency limits macrophage infiltration, preserves lung matrix, and enables lung growth in bronchopulmonary dysplasia	8
Dendritic cell heterogeneity and its role in connective tissue diseases	8
Identification of molecular subtypes based on inflammatory response in lower-grade glioma	8
Unraveling the complex role of microglia in Alzheimer’s disease: amyloid β metabolism and plaque formation	8
Effect of JAK inhibitors on the three forms of bone damage in autoimmune arthritis: joint erosion, periarticular osteopenia, and systemic bone loss	8
Neuroplasticity related to chronic pain and its modulation by microglia	8
Maternal immunoglobulins are distributed in the offspring’s brain to support the maintenance of cortical interneurons in the postnatal period	8
Optimization of transplantation methods using isolated mesenchymal stem/stromal cells: clinical trials of inflammatory bowel diseases as an example	8
Extracellular vesicles from dental pulp mesenchymal stem cells modulate macrophage phenotype during acute and chronic cardiac inflammation in athymic nude rats with myocardial infarction	8
A novel cell-free intrathecal approach with PRP for the treatment of spinal cord multiple sclerosis in cats	8
Accelerating skin regeneration and wound healing by controlled ROS from photodynamic treatment	8
The Ragulator complex: delving its multifunctional impact on metabolism and beyond	8
Duration of SARS-CoV-2 RNA positivity from various specimens and clinical characteristics in patients with COVID-19: a systematic review and meta-analysis	8
Studies on immune regulation for allogeneic iPSC-based transplantation	7
A Sox17 downstream gene Rasip1 is involved in the hematopoietic activity of intra-aortic hematopoietic clusters in the midgestation mouse embryo	7
Controlling skin microbiome as a new bacteriotherapy for inflammatory skin diseases	7
Imatinib inhibits pericyte-fibroblast transition and inflammation and promotes axon regeneration by blocking the PDGF-BB/PDGFRβ pathway in spinal cord injury	7
Mesenchymal stromal cells in the thymus	7
Metabolic network of the gut microbiota in inflammatory bowel disease	7
Autocrine insulin-like growth factor 2 signaling as a potential target in the associated development of pulmonary emphysema and cancer in smokers	7