OOIR: Observatory of International Research

Papers

(The median citation count of Inflammation and Regeneration is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Macrophage depletion in inflamed rat knees prevents the activation of synovial mesenchymal stem cells by weakening Nampt and Spp1 signaling	186
Beyond the bulk: overview and novel insights into the dynamics of muscle satellite cells during muscle regeneration	128
Jdp2 is a spatiotemporal transcriptional activator of the AhR via the Nrf2 gene battery	99
Peripheral and central regulation of neuro–immune crosstalk	78
Molecular mechanism of crosstalk between immune and metabolic systems in metabolic syndrome	67
Ca2+ microdomain-based excitation-transcription coupling in cardiac myocytes and vascular smooth muscle cells	67
Preadipocytes in human granulation tissue: role in wound healing and response to macrophage polarization	55
APJ regulates the balance between self-renewal and differentiation of vascular endothelial stem cells	53
Correction: Autoinflammatory disease: clinical perspectives and therapeutic strategies	53
Cross-talk between nervous, immune, and metabolic systems	53
Organization of self-advantageous niche by neural stem/progenitor cells during development via autocrine VEGF-A under hypoxia	49
Analysis of distribution, collection, and confirmation of capacity dependency of small extracellular vesicles toward a therapy for liver cirrhosis	45
Umbilical cord blood and cord tissue banking as somatic stem cell resources to support medical cell modalities	43
Extracellular vesicles from immortalized mesenchymal stromal cells protect against neonatal hypoxic-ischemic brain injury	40
Acomys cahirinus develop lung stroma distortion but not fibrosis after bleomycin-induced injury	39
Immune cell trafficking: a novel perspective on the gut-skin axis	38
Rapid and high-purity differentiation of human medium spiny neurons reveals LMNB1 hypofunction and subtype necessity in modeling Huntington’s disease	38
Recent advances in immunological mechanisms and murine disease models of idiopathic inflammatory myopathies	36
Promotion of axon regeneration and protection on injured retinal ganglion cells by rCXCL2	32
IFN-γ-STAT1-mediated CD8+ T-cell-neural stem cell cross talk controls astrogliogenesis after spinal cord injury	32
Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation	30
In vivo imaging of inflammatory response in cancer research	28
Cytokines and cytokine receptors as targets of immune-mediated inflammatory diseases—RA as a role model	28
Novel artificial nerve transplantation of human iPSC-derived neurite bundles enhanced nerve regeneration after peripheral nerve injury	28
Pathophysiological functions of semaphorins in the sympathetic nervous system	27

Accelerating corneal wound healing using exosome-mediated targeting of NF-κB c-Rel	27
Role of the Hippo pathway in liver regeneration and repair: recent advances	27
Adipose-derived mesenchymal stem cell therapy for connective tissue diseases and complications	26
A lesion-selective albumin-CTLA4Ig as a safe and effective treatment for collagen-induced arthritis	26
Advances in vascular endothelial cell-mediated regulation of satellite cell repair and regeneration	25
Par2-mediated responses in inflammation and regeneration: choosing between repair and damage	25
Autoinflammatory disease: clinical perspectives and therapeutic strategies	25
Quercetin enhances survival and axonal regeneration of motoneurons after spinal root avulsion and reimplantation: experiments in a rat model of brachial plexus avulsion	23
Innate immune recognition against SARS-CoV-2	23
A human induced pluripotent stem cell model from a patient with hereditary cerebral small vessel disease carrying a heterozygous R302Q mutation in HTRA1	22
Genome editing iPSC to purposing enhancement of induce CD8 killer T cell function for regenerative immunotherapy	22
Destruction and regeneration in bone and cartilage	21
Single transcription factor efficiently leads human induced pluripotent stem cells to functional microglia	21
Epigenetic targets of Janus kinase inhibitors are linked to genetic risks of rheumatoid arthritis	21
A case of refractory systemic lupus erythematosus with monocytosis exhibiting somatic KRAS mutation	20
From bench to bedside: the role of gastrointestinal stem cells in health and disease	19
Generation of a BAC transgenic mouse strain that expresses CreERT and a fluorescent protein under the transcriptional control of the Fzd5 locus	19
Stem cell-based drug delivery strategy for skin regeneration and wound healing: potential clinical applications	19
Characterization of the human gut virome in metabolic and autoimmune diseases	19
Hippo pathway in cell–cell communication: emerging roles in development and regeneration	18
A disease-specific iPS cell resource for studying rare and intractable diseases	17
A review of current status of cell-based therapies for aortic aneurysms	17
Innate immune memory in macrophage differentiation and cardiovascular diseases	16
Functional diversity of disorder-specific macrophages involved in various diseases	16
Intravital imaging of immune responses in intestinal inflammation	15
Th22 is the effector cell of thymosin β15-induced hair regeneration in mice	15
Human PBMC-based humanized mice exhibit myositis features and serve as a drug evaluation model	15
Editorial: Towards a better understanding of the physiology of the lymphatics	15
Research hotspots and trends for axon regeneration (2000–2021): a bibliometric study and systematic review	15
Clinical perspectives and therapeutic strategies: pediatric autoinflammatory disease—a multi-faceted approach to fever of unknown origin of childhood	15
Cancer ego-system in glioma: an iron-replenishing niche network systemically self-organized by cancer stem cells	15
NRP2+ human mesenchymal stem cells have stemness-associated properties	15
Helicobacter pylori infection in the stomach induces neuroinflammation: the potential roles of bacterial outer membrane vesicles in an animal model of Alzheimer’s disease	14
Chronological transitions of hepatocyte growth factor treatment effects in spinal cord injury tissue	14
Cellular niches for hematopoietic stem cells in bone marrow under normal and malignant conditions	13
Cartilage evaluation by ultrasonography in patients with rheumatoid arthritis: a scoping review	13
Potential therapeutic applications of stem cells in animal models of ocular affections	13
A novel prostaglandin I2 agonist, ONO-1301, attenuates liver inflammation and suppresses fibrosis in non-alcoholic steatohepatitis model mice	13
Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice	12
SPARC activates p38γ signaling to promote PFKFB3 protein stabilization and contributes to keloid fibroblast glycolysis	12
Targeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer’s disease	12
Canonical Wnt signaling activation by chimeric antigen receptors for efficient cardiac differentiation from mouse embryonic stem cells	12
The oral-gut axis: a missing piece in the IBD puzzle	12
The role of Staphylococcus aureus quorum sensing in cutaneous and systemic infections	11
Significance of the multiomics approach to elucidate disease mechanisms in humans	11
Matrix remodeling associated 7 proteins promote cutaneous wound healing through vimentin in coordinating fibroblast functions	11
Regeneration of invariant natural killer T (iNKT) cells: application of iPSC technology for iNKT cell-targeted tumor immunotherapy	11
Versatile extracellular vesicle-mediated information transfer: intercellular synchronization of differentiation and of cellular phenotypes, and future perspectives	11
Testosterone upregulates glial cell line-derived neurotrophic factor (GDNF) and promotes neuroinflammation to enhance glioma cell survival and proliferation	11
Ex vivo lung-organoid model for aberrant basaloid cell induction and activation	10

The impact of T cells on immune-related liver diseases: an overview	10
Next-generation proteomics of serum extracellular vesicles combined with single-cell RNA sequencing identifies MACROH2A1 associated with refractory COVID-19	10
Marine-derived microbes and molecules for drug discovery	10
Arthritis-associated osteoclastogenic macrophage, AtoM, as a key player in pathological bone erosion	10
Designer immune cells	10
Emerging roles of inflammation-mediated endothelial–mesenchymal transition in health and disease	10
Inter-organ communication involved in metabolic regulation at the whole-body level	10
A novel cell-free intrathecal approach with PRP for the treatment of spinal cord multiple sclerosis in cats	9
Effect of JAK inhibitors on the three forms of bone damage in autoimmune arthritis: joint erosion, periarticular osteopenia, and systemic bone loss	9
Identification of molecular subtypes based on inflammatory response in lower-grade glioma	9
Osteoclast biology in the single-cell era	9
Effect of aging on the formation and growth of colonic epithelial organoids by changes in cell cycle arrest through TGF-β-Smad3 signaling	9
The Ragulator complex: delving its multifunctional impact on metabolism and beyond	9
Neuroplasticity related to chronic pain and its modulation by microglia	9
Multi-organ frailty is enhanced by periodontitis-induced inflammaging	9
Function of alveolar macrophages in lung cancer microenvironment	9
Enhancement of bone regeneration by coadministration of angiogenic and osteogenic factors using messenger RNA	9
Dendritic cell heterogeneity and its role in connective tissue diseases	9
Cell fusion dynamics: mechanisms of multinucleation in osteoclasts and macrophages	9
Extracellular vesicles from dental pulp mesenchymal stem cells modulate macrophage phenotype during acute and chronic cardiac inflammation in athymic nude rats with myocardial infarction	9
Metabolic network of the gut microbiota in inflammatory bowel disease	8
Unraveling the complex role of microglia in Alzheimer’s disease: amyloid β metabolism and plaque formation	8
Duration of SARS-CoV-2 RNA positivity from various specimens and clinical characteristics in patients with COVID-19: a systematic review and meta-analysis	8
Imatinib inhibits pericyte-fibroblast transition and inflammation and promotes axon regeneration by blocking the PDGF-BB/PDGFRβ pathway in spinal cord injury	8
Atypical cholangiocytes derived from hepatocyte-cholangiocyte transdifferentiation mediated by COX-2: a kind of misguided liver regeneration	8
CXCL10 deficiency limits macrophage infiltration, preserves lung matrix, and enables lung growth in bronchopulmonary dysplasia	8
Maternal immunoglobulins are distributed in the offspring’s brain to support the maintenance of cortical interneurons in the postnatal period	8
Accelerating skin regeneration and wound healing by controlled ROS from photodynamic treatment	8
Optimization of transplantation methods using isolated mesenchymal stem/stromal cells: clinical trials of inflammatory bowel diseases as an example	8
Autocrine insulin-like growth factor 2 signaling as a potential target in the associated development of pulmonary emphysema and cancer in smokers	7
Controlling skin microbiome as a new bacteriotherapy for inflammatory skin diseases	7
Studies on immune regulation for allogeneic iPSC-based transplantation	7
Mesenchymal stromal cells in the thymus	7
Stem cell modelling of osteoarthritis using an organ-on-a-chip approach	7
A Sox17 downstream gene Rasip1 is involved in the hematopoietic activity of intra-aortic hematopoietic clusters in the midgestation mouse embryo	7
Molecular hydrogen promotes wound healing by inducing early epidermal stem cell proliferation and extracellular matrix deposition	7